zona fasciculata

Summary

Summary: The wide middle zone of the adrenal cortex. This zone produces a series of enzymes that convert PREGNENOLONE to cortisol (HYDROCORTISONE) via 17-ALPHA-HYDROXYPROGESTERONE.

Top Publications

  1. Wang S, Pu H, Kan S, Tseng C, Lo M, Wang P. Inhibitory effects of digoxin and digitoxin on corticosterone production in rat zona fasciculata-reticularis cells. Br J Pharmacol. 2004;142:1123-30 pubmed
    ..The concentration of corticosterone in the rat plasma samples was measured by radioimmunoassay. Zona fasciculata-reticularis (ZFR) cells in male rats were prepared and then incubated with or without digoxin or digitoxin in ..
  2. Danthi S, Enyeart J, Enyeart J. Modulation of native TREK-1 and Kv1.4 K+ channels by polyunsaturated fatty acids and lysophospholipids. J Membr Biol. 2003;195:147-64 pubmed
    ..4 voltage-gated K+ channels by fatty acids and lysophospholipids was studied in bovine adrenal zona fasciculata (AZF) cells...
  3. Liu H, Enyeart J, Enyeart J. Angiotensin II inhibits native bTREK-1 K+ channels through a PLC-, kinase C-, and PIP2-independent pathway requiring ATP hydrolysis. Am J Physiol Cell Physiol. 2007;293:C682-95 pubmed
    ..Whole cell patch-clamp recording from bovine adrenal zona fasciculata (AZF) cells was used to characterize the ATP-dependent signaling mechanism for inhibition of bTREK-1 by ANG ..
  4. Milosevic V, Trifunovic S, Sekulic M, Sosic Jurjevic B, Filipovic B, Negić N, et al. Chronic exposure to constant light affects morphology and secretion of adrenal zona fasciculata cells in female rats. Gen Physiol Biophys. 2005;24:299-309 pubmed
    ..of chronic exposure to light of adult Wistar rats on growth and function of adrenal zona glomerulosa (ZG) and zona fasciculata (ZF) were examined...
  5. Chang L, Kau M, Wun W, Ho L, Wang P. Effects of fasting on corticosterone production by zona fasciculata-reticularis cells in ovariectomized rats. J Investig Med. 2002;50:86-94 pubmed
    To investigate the function and mechanism of fasting on the production of corticosterone in vitro by zona fasciculata-reticularis (ZFR) cells from ovariectomized (OVX) rats.
  6. Koldzic Zivanovic N, Tu H, Juelich T, Rady P, Tyring S, Hudnall S, et al. Regulation of adrenal glucocorticoid synthesis by interleukin-10: a preponderance of IL-10 receptor in the adrenal zona fasciculata. Brain Behav Immun. 2006;20:460-8 pubmed
    ..shows that the region of the adrenal gland responsible for the vast majority of corticosterone synthesis, the zona fasciculata, predominantly expresses the IL-10 receptor 1 (IL-10R1), with little expression in the zona glomerulosa and ..
  7. Mitani F, Mukai K, Miyamoto H, Suematsu M, Ishimura Y. The undifferentiated cell zone is a stem cell zone in adult rat adrenal cortex. Biochim Biophys Acta. 2003;1619:317-24 pubmed
    ..e. the zona glomerulosa (zG), the zona fasciculata (zF) and the zona reticularis (zR), each of which secretes a specific corticosteroid different from those ..
  8. Fang V, Juan C, Won J, Ho L. Further study of aldosterone secretion-inhibitory factor and brain natriuretic peptide on cortisol production of guinea pig zona fasciculata cells. Chin J Physiol. 2000;43:141-7 pubmed
    ..BNP-32) on the basal and ACTH-stimulated cortisol production in a primary culture enriched with guinea pig Zona Fasciculata (ZF) cells was further studied...
  9. Raza F, Takemori H, Tojo H, Okamoto M, Vinson G. Identification of the rat adrenal zona fasciculata/reticularis specific protein, inner zone antigen (IZAg), as the putative membrane progesterone receptor. Eur J Biochem. 2001;268:2141-7 pubmed
    ..More detailed examination of the distribution of this protein, not only in the zona fasciculata/reticularis of the adrenal cortex, but also in the Leydig cell, kidney and liver, suggest it may have a role ..
  10. Liu H, Enyeart J, Enyeart J. ACTH induces Cav3.2 current and mRNA by cAMP-dependent and cAMP-independent mechanisms. J Biol Chem. 2010;285:20040-50 pubmed publisher
    Bovine adrenal zona fasciculata (AZF) cells express Ca(v)3.2 T-type Ca(2+) channels that function pivotally in adrenocorticotropic hormone (ACTH)-stimulated cortisol secretion. The regulation of Ca(v)3...

Detail Information

Publications96

  1. Wang S, Pu H, Kan S, Tseng C, Lo M, Wang P. Inhibitory effects of digoxin and digitoxin on corticosterone production in rat zona fasciculata-reticularis cells. Br J Pharmacol. 2004;142:1123-30 pubmed
    ..The concentration of corticosterone in the rat plasma samples was measured by radioimmunoassay. Zona fasciculata-reticularis (ZFR) cells in male rats were prepared and then incubated with or without digoxin or digitoxin in ..
  2. Danthi S, Enyeart J, Enyeart J. Modulation of native TREK-1 and Kv1.4 K+ channels by polyunsaturated fatty acids and lysophospholipids. J Membr Biol. 2003;195:147-64 pubmed
    ..4 voltage-gated K+ channels by fatty acids and lysophospholipids was studied in bovine adrenal zona fasciculata (AZF) cells...
  3. Liu H, Enyeart J, Enyeart J. Angiotensin II inhibits native bTREK-1 K+ channels through a PLC-, kinase C-, and PIP2-independent pathway requiring ATP hydrolysis. Am J Physiol Cell Physiol. 2007;293:C682-95 pubmed
    ..Whole cell patch-clamp recording from bovine adrenal zona fasciculata (AZF) cells was used to characterize the ATP-dependent signaling mechanism for inhibition of bTREK-1 by ANG ..
  4. Milosevic V, Trifunovic S, Sekulic M, Sosic Jurjevic B, Filipovic B, Negić N, et al. Chronic exposure to constant light affects morphology and secretion of adrenal zona fasciculata cells in female rats. Gen Physiol Biophys. 2005;24:299-309 pubmed
    ..of chronic exposure to light of adult Wistar rats on growth and function of adrenal zona glomerulosa (ZG) and zona fasciculata (ZF) were examined...
  5. Chang L, Kau M, Wun W, Ho L, Wang P. Effects of fasting on corticosterone production by zona fasciculata-reticularis cells in ovariectomized rats. J Investig Med. 2002;50:86-94 pubmed
    To investigate the function and mechanism of fasting on the production of corticosterone in vitro by zona fasciculata-reticularis (ZFR) cells from ovariectomized (OVX) rats.
  6. Koldzic Zivanovic N, Tu H, Juelich T, Rady P, Tyring S, Hudnall S, et al. Regulation of adrenal glucocorticoid synthesis by interleukin-10: a preponderance of IL-10 receptor in the adrenal zona fasciculata. Brain Behav Immun. 2006;20:460-8 pubmed
    ..shows that the region of the adrenal gland responsible for the vast majority of corticosterone synthesis, the zona fasciculata, predominantly expresses the IL-10 receptor 1 (IL-10R1), with little expression in the zona glomerulosa and ..
  7. Mitani F, Mukai K, Miyamoto H, Suematsu M, Ishimura Y. The undifferentiated cell zone is a stem cell zone in adult rat adrenal cortex. Biochim Biophys Acta. 2003;1619:317-24 pubmed
    ..e. the zona glomerulosa (zG), the zona fasciculata (zF) and the zona reticularis (zR), each of which secretes a specific corticosteroid different from those ..
  8. Fang V, Juan C, Won J, Ho L. Further study of aldosterone secretion-inhibitory factor and brain natriuretic peptide on cortisol production of guinea pig zona fasciculata cells. Chin J Physiol. 2000;43:141-7 pubmed
    ..BNP-32) on the basal and ACTH-stimulated cortisol production in a primary culture enriched with guinea pig Zona Fasciculata (ZF) cells was further studied...
  9. Raza F, Takemori H, Tojo H, Okamoto M, Vinson G. Identification of the rat adrenal zona fasciculata/reticularis specific protein, inner zone antigen (IZAg), as the putative membrane progesterone receptor. Eur J Biochem. 2001;268:2141-7 pubmed
    ..More detailed examination of the distribution of this protein, not only in the zona fasciculata/reticularis of the adrenal cortex, but also in the Leydig cell, kidney and liver, suggest it may have a role ..
  10. Liu H, Enyeart J, Enyeart J. ACTH induces Cav3.2 current and mRNA by cAMP-dependent and cAMP-independent mechanisms. J Biol Chem. 2010;285:20040-50 pubmed publisher
    Bovine adrenal zona fasciculata (AZF) cells express Ca(v)3.2 T-type Ca(2+) channels that function pivotally in adrenocorticotropic hormone (ACTH)-stimulated cortisol secretion. The regulation of Ca(v)3...
  11. Yu P, Chao H, Wang S, Wang P. Effects of evodiamine and rutaecarpine on the secretion of corticosterone by zona fasciculata-reticularis cells in male rats. J Cell Biochem. 2009;108:469-75 pubmed publisher
    ..of this study was to characterize the mechanism by which EVO and RUT affect corticosterone production in rat zona fasciculata-reticularis (ZFR) cells...
  12. Liu H, Enyeart J, Enyeart J. ACTH inhibits bTREK-1 K+ channels through multiple cAMP-dependent signaling pathways. J Gen Physiol. 2008;132:279-94 pubmed publisher
    Bovine adrenal zona fasciculata (AZF) cells express bTREK-1 K(+) channels that set the resting membrane potential and function pivotally in the physiology of cortisol secretion...
  13. Danthi S, Enyeart J, Enyeart J. Caffeic acid esters activate TREK-1 potassium channels and inhibit depolarization-dependent secretion. Mol Pharmacol. 2004;65:599-610 pubmed
    ..In bovine adrenal zona fasciculata (AZF) cells, bTREK-1 K+ channels set the resting membrane potential...
  14. Omura M, Suematsu S, Nishikawa T. Role of calcium messenger systems in ACTH-induced cortisol production in bovine adrenal fasciculo-reticularis cells. Endocr J. 2007;54:585-92 pubmed
    ..A phospholipase A2-dependent process may partly play a crucial role in the regulation of cortisol biosynthesis, when stimulated by low and high concentrations of ACTH...
  15. Enyeart J, Mlinar B, Enyeart J. T-type Ca2+ channels are required for adrenocorticotropin-stimulated cortisol production by bovine adrenal zona fasciculata cells. Mol Endocrinol. 1993;7:1031-40 pubmed
    ..of low voltage-activated T-type Ca2+ channels in ACTH-stimulated cortisol production by bovine adrenal zona fasciculata cells (AZF) was explored in patch clamp and secretion studies...
  16. Frederiks W, Kümmerlin I, Bosch K, Vreeling Sindelárová H, Jonker A, Van Noorden C. NADPH production by the pentose phosphate pathway in the zona fasciculata of rat adrenal gland. J Histochem Cytochem. 2007;55:975-80 pubmed
    ..The four enzymes have similar localization patterns in adrenal gland with highest activities in the zona fasciculata of the cortex...
  17. Wang W, Wang L, Endoh A, Hummelke G, Hawks C, Hornsby P. Identification of alpha-enolase as a nuclear DNA-binding protein in the zona fasciculata but not the zona reticularis of the human adrenal cortex. J Endocrinol. 2005;184:85-94 pubmed
    In order to establish whether there are differences in DNA-binding proteins between zona fasciculata (ZF) and zona reticularis (ZR) cells of the human adrenal cortex, we prepared nuclear extracts from separated ZF and ZR cells...
  18. Enyeart J, Danthi S, Enyeart J. Corticotropin induces the expression of TREK-1 mRNA and K+ current in adrenocortical cells. Mol Pharmacol. 2003;64:132-42 pubmed
    Bovine adrenal zona fasciculata (AZF) cells express a two-pore/four-transmembrane segment bTREK-1 K+ channel that sets the resting potential and couples hormonal signals to depolarization-dependent Ca2+ entry and cortisol secretion...
  19. Nishimoto K, Rigsby C, Wang T, Mukai K, Gomez Sanchez C, Rainey W, et al. Transcriptome analysis reveals differentially expressed transcripts in rat adrenal zona glomerulosa and zona fasciculata. Endocrinology. 2012;153:1755-63 pubmed publisher
    ..glomerulosa (zG), the outermost layer of the adrenal cortex, whereas glucocorticoids are produced in adjacent zona fasciculata (zF)...
  20. Chang L, Wun W, Wang P. Mechanisms of inhibition of dehydroepiandrosterone upon corticosterone release from rat zona fasciculata-reticularis cells. J Cell Biochem. 2008;104:359-68 pubmed
    We have demonstrated that dehydroepiandrosterone (DHEA) acts directly on rat zona fasciculata-reticularis (ZFR) cells to diminish corticosterone secretion by an inhibition of post-cAMP pathway, and decreases functions of steroidogenic ..
  21. Enyeart J, Liu H, Enyeart J. Calcium-dependent inhibition of adrenal TREK-1 channels by angiotensin II and ionomycin. Am J Physiol Cell Physiol. 2011;301:C619-29 pubmed publisher
    ..Whole cell and single patch clamp recording from adrenal zona fasciculata (AZF) cells were used to characterize Ca(2+)-dependent inhibition of bTREK-1...
  22. Hwang G, Chen C, Chou J, Chang L, Kan S, Lai W, et al. Stimulatory Effect of Intermittent Hypoxia on the Production of Corticosterone by Zona Fasciculata-Reticularis Cells in Rats. Sci Rep. 2017;7:9035 pubmed publisher
    ..These results suggest that IH in rats increases the secretion of corticosterone via a mechanism at least in part associated with the activation of cAMP pathway and steroidogenic enzymes. ..
  23. Bielohuby M, Herbach N, Wanke R, Maser Gluth C, Beuschlein F, Wolf E, et al. Growth analysis of the mouse adrenal gland from weaning to adulthood: time- and gender-dependent alterations of cell size and number in the cortical compartment. Am J Physiol Endocrinol Metab. 2007;293:E139-46 pubmed
    ..Female adrenal glands displayed a higher weight at any stage investigated. The volume of the zona fasciculata was consistently higher in female vs. male mice...
  24. Schrier A, Wang H, Talley E, Perez Reyes E, Barrett P. alpha1H T-type Ca2+ channel is the predominant subtype expressed in bovine and rat zona glomerulosa. Am J Physiol Cell Physiol. 2001;280:C265-72 pubmed
    ..A much weaker expression signal was detected for the alpha1H transcript in the zona fasciculata of bovine...
  25. Fallo F, Castellano I, Gomez Sanchez C, Rhayem Y, Pilon C, Vicennati V, et al. Histopathological and genetic characterization of aldosterone-producing adenomas with concurrent subclinical cortisol hypersecretion: a case series. Endocrine. 2017;58:503-512 pubmed publisher
    ..Cellular composition was determined by examining for known features of zona fasciculata and zona glomerulosa, and immunoreactivity for CYP11B1 and CYP11B2 by McCarty H-score...
  26. Lenders J, Williams T, Reincke M, Gomez Sanchez C. DIAGNOSIS OF ENDOCRINE DISEASE: 18-Oxocortisol and 18-Hydroxycortisol. Is there clinical utility of these steroids?. Eur J Endocrinol. 2017;: pubmed publisher
    ..and 18-oxocortisol the action of both aldosterone synthase (zona glomerulosa) and 17?-hydroxylase (zona fasciculata) is required with cortisol as main substrate...
  27. Suwa T, Chen M, Hawks C, Hornsby P. Zonal expression of dickkopf-3 and components of the Wnt signalling pathways in the human adrenal cortex. J Endocrinol. 2003;178:149-58 pubmed
    ..Microarray studies on RNA from microdissected zona reticularis (ZR) and zona fasciculata/zona glomerulosa (ZF/ZG) derived from adult human adrenal glands showed that a gene of the dickkopf family (..
  28. Nishimoto K, Koga M, Seki T, Oki K, Gomez Sanchez E, Gomez Sanchez C, et al. Immunohistochemistry of aldosterone synthase leads the way to the pathogenesis of primary aldosteronism. Mol Cell Endocrinol. 2017;441:124-133 pubmed publisher
    ..rats, there is layered functional zonation with the Cyp11b2-positive zona glomerulosa (ZG), Cyp11b1-positive zona fasciculata (ZF), and Cyp11b2/Cyp11b1-negative undifferentiated zone between the ZG and ZF...
  29. Bhatt M, Khatri Y, Rodgers R, Martin L. Role of cytochrome b5 in the modulation of the enzymatic activities of cytochrome P450 17α-hydroxylase/17,20-lyase (P450 17A1). J Steroid Biochem Mol Biol. 2017;170:2-18 pubmed publisher
    ..Located in the zona fasciculata and zona reticularis of the adrenal cortex and in the gonads, P450 17A1 catalyzes two different reactions in ..
  30. Suzuki T, Sasano H, Takeyama J, Kaneko C, Freije W, Carr B, et al. Developmental changes in steroidogenic enzymes in human postnatal adrenal cortex: immunohistochemical studies. Clin Endocrinol (Oxf). 2000;53:739-47 pubmed
    ..P450c17 and DHEA-ST immunoreactivity was weak in the zona fasciculata and reticularis in the adrenals of age 7 months to 5 years, but thereafter became prominent in the zona ..
  31. Tokar S, Koval L, Iavors ka O, Luk ianets O. [Ultrastructural characteristics of lipid droplets in rat adrenocortical cells from zona fasciculata-reticularis]. Fiziol Zh. 2004;50:107-13 pubmed
    One day cultured adrenocortical cells from zona fasciculata-reticularis were used in morphological experiments...
  32. Li H, Brochu M, Wang S, Rochdi L, Côté M, Mitchell G, et al. Hormone-sensitive lipase deficiency in mice causes lipid storage in the adrenal cortex and impaired corticosterone response to corticotropin stimulation. Endocrinology. 2002;143:3333-40 pubmed
    ..animals, HSL deficiency results in a marked accumulation of lipid droplets both in zona glomerulosa and zona fasciculata. In the zona fasciculata, lipid accumulation was observed progressively from the outer to the inner regions, ..
  33. Battista M, Roberge C, Otis M, Gallo Payet N. Seladin-1 expression in rat adrenal gland: effect of adrenocorticotropic hormone treatment. J Endocrinol. 2007;192:53-66 pubmed
    ..Immunofluorescence studies revealed that Seladin-1 was localized principally in the zona fasciculata, cytoplasm, and nucleus...
  34. Ragazzon B, Lefrançois Martinez A, Val P, Sahut Barnola I, Tournaire C, Chambon C, et al. Adrenocorticotropin-dependent changes in SF-1/DAX-1 ratio influence steroidogenic genes expression in a novel model of glucocorticoid-producing adrenocortical cell lines derived from targeted tumorigenesis. Endocrinology. 2006;147:1805-18 pubmed
    We established the first adrenocortical tumor cell lines with complete zona fasciculata (ZF) cell phenotype from tumors induced in transgenic mice by large T-antigen of simian virus 40 under the control of the aldose reductase-like akr1b7 ..
  35. Pignatti E, Leng S, Carlone D, Breault D. Regulation of zonation and homeostasis in the adrenal cortex. Mol Cell Endocrinol. 2017;441:146-155 pubmed publisher
    ..from the outer to the inner cortex, which is accompanied by direct conversion of zona glomerulosa (zG) into zona fasciculata (zF) cells...
  36. Vänttinen T, Liu J, Kuulasmaa T, Kivinen P, Voutilainen R. Expression of activin/inhibin signaling components in the human adrenal gland and the effects of activins and inhibins on adrenocortical steroidogenesis and apoptosis. J Endocrinol. 2003;178:479-89 pubmed
    ..the adrenal cortex, whereas Smad4 expression was seen mainly in the zona reticularis and the innermost zona fasciculata as evaluated by immunohistochemistry...
  37. Maniero C, Zhou J, Shaikh L, Azizan E, McFarlane I, Neogi S, et al. Role of ANO4 in regulation of aldosterone secretion in the zona glomerulosa of the human adrenal gland. Lancet. 2015;385 Suppl 1:S62 pubmed publisher
    ..from zona glomerulosa, we carried out a microarray analysis comparing transcriptomes of zona glomerulosa, zona fasciculata, and tumour in human adrenal tissue, and investigated the functional role of genes upregulated in the zona ..
  38. Kawamura M, Terasaka O, Ebisawa T, Kondo I, Masaki E, Ahmed A, et al. Integrity of actin-network is involved in uridine 5'-triphosphate evoked store-operated Ca2+ entry in bovine adrenocortical fasciculata cells. J Pharmacol Sci. 2003;91:23-33 pubmed
  39. Koko V, Djordjeviae J, Cvijiae G, Davidoviae V. Effect of acute heat stress on rat adrenal glands: a morphological and stereological study. J Exp Biol. 2004;207:4225-30 pubmed
    ..and volume were decreased, probably as the consequence of adrenal cortex reduction, especially that of the zona fasciculata (ZF). Histological examination revealed that many ZF cells were deprived of lipid droplets...
  40. Astort F, Repetto E, Martinez Calejman C, Cipelli J, Sanchez R, Di Gruccio J, et al. High glucose-induced changes in steroid production in adrenal cells. Diabetes Metab Res Rev. 2009;25:477-86 pubmed publisher
    ..HG induces oxidative stress and affects steroid production in adrenal cells; the involvement of HO activity in the modulation of steroidogenesis in Y1 cells is postulated. ..
  41. Roucher Boulez F, Brac de la Perrière A, Jacquez A, Chau D, Guignat L, Vial C, et al. Triple-A syndrome: a wide spectrum of adrenal dysfunction. Eur J Endocrinol. 2018;178:199-207 pubmed publisher
    ..755G>C, p.(Trp252Ser). Regarding adrenal function, defects of the zona fasciculata and reticularis were demonstrated by increased basal ACTH levels and low DHEAS levels in all cases regardless ..
  42. Xu L, Xia W, Wu X, Wang X, Zhao L, Nie M. Chimeric CYP11B2/CYP11B1 causing 11β-hydroxylase deficiency in Chinese patients with congenital adrenal hyperplasia. Steroids. 2015;101:51-5 pubmed publisher
    ..We hypothesize that the lack expression of CYP11B1 under the control of the CYP11B2 promoter in zona fasciculata may contribute to a cortisol defect as well as the resultant 11-OHD.
  43. Drelon C, Berthon A, Sahut Barnola I, Mathieu M, Dumontet T, Rodriguez S, et al. PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development. Nat Commun. 2016;7:12751 pubmed publisher
    ..zonation, essential for production of aldosterone by outer zona glomerulosa (ZG) and glucocorticoids by inner zona fasciculata (ZF)...
  44. Gorrigan R, Guasti L, King P, Clark A, Chan L. Localisation of the melanocortin-2-receptor and its accessory proteins in the developing and adult adrenal gland. J Mol Endocrinol. 2011;46:227-32 pubmed publisher
    ..In this study on the rat adrenal gland, we demonstrate that while MRAP and MC2R are highly expressed in the zona fasciculata, MRAP2 is expressed throughout the adrenal cortex in low quantities...
  45. Celichowski P, Jopek K, Szyszka M, Tyczewska M, Malendowicz L, Rucinski M. Mitochondrial sirtuins in the rat adrenal gland: location within the glands of males and females, hormonal and developmental regulation of gene expressions. Folia Histochem Cytobiol. 2017;55:190-202 pubmed publisher
    ..The level of expression of all sirtuins is higher in the zona glomerulosa (ZG) and zona fasciculata/reticularis (ZF/R) than in the adrenal medulla...
  46. Gleicher N, Kushnir V, Darmon S, Wang Q, Zhang L, Albertini D, et al. Suspected ontogeny of a recently described hypo-androgenic PCOS-like phenotype with advancing age. Endocrine. 2018;59:661-676 pubmed publisher
    ..controls (likely autoimmune-induced) insufficiency of the adrenal zona reticularis (low-T and low-DHEAS) and zona fasciculata (low-C), and is characterized by frequent evidence of autoimmunity...
  47. Torres T, Lotfi C. Distribution of cells expressing Jun and Fos proteins and synthesizing DNA in the adrenal cortex of hypophysectomized rats: regulation by ACTH and FGF2. Cell Tissue Res. 2007;329:443-55 pubmed
    ..at 2 days after hypophysectomy, although a reduction occurred in the number of BrdU-positive cells in the zona fasciculata. This hypophysectomy-induced early phase of adrenal cortex atrophy in the zona fasciculata was correlated ..
  48. Nishimoto K, Rainey W, Bollag W, Seki T. Lessons from the gene expression pattern of the rat zona glomerulosa. Mol Cell Endocrinol. 2013;371:107-13 pubmed publisher
    We recently identified hundreds of transcripts with differential expression in rat zona glomerulosa (zG) and zona fasciculata. Although the genes up-regulated in the zG may be playing important roles in aldosterone production, the ..
  49. Trut L, Prasolova L, Kharlamova A, Plyusnina I. Directional left-sided asymmetry of adrenals in experimentally domesticated animals. Bull Exp Biol Med. 2002;133:506-9 pubmed
    ..In aggressive animals enlargement of the left adrenal cortex was associated with widening of the zona reticularis, while in domesticated animals with enlargement of the zona fasciculata.
  50. Enyeart J, Enyeart J. Metabolites of an Epac-selective cAMP analog induce cortisol synthesis by adrenocortical cells through a cAMP-independent pathway. PLoS ONE. 2009;4:e6088 pubmed publisher
    Adrenal zona fasciculata (AZF) cells express a cAMP-activated guanine nucleotide exchange protein (Epac2) that may function in ACTH-stimulated cortisol synthesis...
  51. Dorovini Zis K, Zis A. Innervation of the zona fasciculata of the adult human adrenal cortex: a light and electron microscopic study. J Neural Transm Gen Sect. 1991;84:75-84 pubmed
    ..Detailed ultrastructural studies on the innervation of the zona fasciculata of the normal human adrenal cortex are lacking...
  52. Bandulik S, Tauber P, Penton D, Schweda F, Tegtmeier I, Sterner C, et al. Severe hyperaldosteronism in neonatal Task3 potassium channel knockout mice is associated with activation of the intraadrenal renin-angiotensin system. Endocrinology. 2013;154:2712-22 pubmed publisher
    ..strong increase in adrenal renin expression, and immunofluorescence revealed renin-expressing cells in the zona fasciculata. Together with additional factors, activation of the local adrenal renin system is probably causative for the ..
  53. Mattos G, Lotfi C. Differences between the growth regulatory pathways in primary rat adrenal cells and mouse tumor cell line. Mol Cell Endocrinol. 2005;245:31-42 pubmed
  54. Cymeryng C, Lotito S, Colonna C, Finkielstein C, Pomeraniec Y, Grión N, et al. Expression of nitric oxide synthases in rat adrenal zona fasciculata cells. Endocrinology. 2002;143:1235-42 pubmed
    Nitric oxide (NO) synthase (NOS) expression was analyzed in rat adrenal zona fasciculata. Both neuronal NOS and endothelial NOS mRNAs were detected by RT-PCR, immunohistochemistry, and immunoblot analysis...
  55. Enyeart J, Xu L, Enyeart J. Dual actions of lanthanides on ACTH-inhibited leak K(+) channels. Am J Physiol Endocrinol Metab. 2002;282:E1255-66 pubmed
    Bovine adrenal zona fasciculata cells express background K(+) channels (I(AC) channels) whose activity is potently inhibited by ACTH...
  56. Val P, Martinez A, Sahut Barnola I, Jean C, Veyssiere G, Lefrançois Martinez A. A 77-base pair LINE-like sequence elicits androgen-dependent mvdp/akr1-b7 expression in mouse vas deferens, but is dispensable for adrenal expression in rats. Endocrinology. 2002;143:3435-48 pubmed
    ..We propose that this acquired androgen-responsive region may be responsible for vas deferens androgen-regulated gene expression in vivo...
  57. Chang L, Wun W, Ho L, Wang P. Effects of dehydroepiandrosterone on corticosterone release in rat zona fasciculata-reticularis cells. Naunyn Schmiedebergs Arch Pharmacol. 2003;368:487-95 pubmed
    ..corticosterone have been proposed in a rat model, the effects and action mechanisms of DHEA on rat adrenal zona fasciculata-reticularis (ZFR) cells are still unclear...
  58. Connell J, Fraser R, MacKenzie S, Friel E, Ingram M, Holloway C, et al. The impact of polymorphisms in the gene encoding aldosterone synthase (CYP11B2) on steroid synthesis and blood pressure regulation. Mol Cell Endocrinol. 2004;217:243-7 pubmed
    ..urinary levels of 11-deoxycortisol suggest that there is relative inefficiency of 11beta-hydroxylation in the zona fasciculata; the P450 enzyme responsible for this step is encoded by the gene CYP11B1, which is highly homologous with ..
  59. Ribes A, Mohamed F, Dominguez S, Delgado M, Scardapane L, Guzman J, et al. Probable effect of photoperiod on seasonal variation in the nuclear volume of the adrenal cortex of viscacha (Lagostomus maximus maximus). Braz J Med Biol Res. 1999;32:1115-20 pubmed
    ..58 +/- 4.53 microm3 for the reticularis. The short winter photoperiod to which viscacha is subjected could inhibit the adrenal cortex through a melatonin increase which reduces the nuclear volume as well as the cellular activity...
  60. Cote M, Guillon G, Payet M, Gallo Payet N. Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland. J Clin Endocrinol Metab. 2001;86:4495-503 pubmed
    ..the two adrenocortical zones, except for adenylyl cyclase 5/6, which had a lower level of expression in the zona fasciculata. We next evaluated the role of the various adenylyl cyclase isoforms during ACTH-stimulated cAMP production ..
  61. Sarkar D, Imai T, Kambe F, Shibata A, Ohmori S, Siddiq A, et al. The human homolog of Diminuto/Dwarf1 gene (hDiminuto): a novel ACTH-responsive gene overexpressed in benign cortisol-producing adrenocortical adenomas. J Clin Endocrinol Metab. 2001;86:5130-7 pubmed
    ..The expression of hDiminuto in the normal adrenal cortex was most abundant in the zona fasciculata, suggesting its possible regulation by ACTH/cAMP...
  62. Pihlajoki M, Heikinheimo M, Wilson D. Never underestimate the complexity of remodeling. Endocrinology. 2013;154:4446-9 pubmed publisher
  63. Hasegawa E, Nakagawa S, Miyate Y, Takahashi K, Ohta S, Tachikawa E, et al. Inhibitory effect of protopanaxatriol ginseng metabolite M4 on the production of corticosteroids in ACTH-stimulated bovine adrenal fasciculata cells. Life Sci. 2013;92:687-93 pubmed publisher
  64. Lo M, Lee S. Direct effects of IL-15 on corticosterone secretion by rat adrenocortical cells. Immunol Cell Biol. 2006;84:38-43 pubmed
    ..were designed to assess the direct effect of IL-15 on corticosterone (CORT) secretion in the adrenal zona fasciculata-reticularis (ZFR) cells of male rats...
  65. Kuribayashi I, Nomoto S, Massa G, Oostdijk W, Wit J, Wolffenbuttel B, et al. Steroid 11-beta-hydroxylase deficiency caused by compound heterozygosity for a novel mutation, p.G314R, in one CYP11B1 allele, and a chimeric CYP11B2/CYP11B1 in the other allele. Horm Res. 2005;63:284-93 pubmed
    ..In order to better understand the molecular basis causing 11beta-OHD, we performed detailed studies of CYP11B1 in a newly described patient diagnosed with the classical signs of 11beta-OHD...
  66. Kawamura M, Niitsu A, Nishi H, Masaki E. Extracellular ATP potentiates steroidogenic effect of adrenocorticotropic hormone in bovine adrenocortical fasciculata cells. Jpn J Pharmacol. 2001;85:376-81 pubmed
    ..These results suggest that extracellular ATP affected the ACTH receptor-adenylyl cyclase coupling processes, and potentiation of steroidogenesis by ACTH ensued in bovine adrenocortical fasciculata cells...
  67. Semplicini A, Ceolotto G, Baritono E, Malendowicz L, Andreis P, Sartori M, et al. Adrenomedullin stimulates DNA synthesis of rat adrenal zona glomerulosa cells through activation of the mitogen-activated protein kinase-dependent cascade. J Hypertens. 2001;19:599-602 pubmed
    ..Adrenal zona glomerulosa cells are provided with adrenomedullin receptors. Adrenomedullin has recently been found to enhance proliferation of cultured rat vascular smooth muscle cells and zona glomerulosa cells...
  68. Rebuffat P, Aragona F, Tortorella C, Malendowicz L, Nussdorfer G. Signaling pathways involved in the A and B receptor-mediated cortisol secretagogue effect of endothelins in the human adrenal cortex. Int J Mol Med. 2001;7:301-5 pubmed
    ..Dispersed zona fasciculata-reticularis (ZF/R) cells were obtained by collagenase digestion and mechanical disaggregation...
  69. Zamfir C, Irimiea L, Indrei A, Indrei L, Trandafirescu M, Carja L. [The cell-cell interaction mechanisms and specific reactions in zona fasciculata cells from the adrenal gland]. Rev Med Chir Soc Med Nat Iasi. 2002;107:273-5 pubmed
    It seems that the particular intermediary disposal of zona fasciculata in the cortical ensemble of the adrenal gland is not insignificant, especially for the variability and for the glandular activities...
  70. Nishimoto K, Nakagawa K, Li D, Kosaka T, Oya M, Mikami S, et al. Adrenocortical zonation in humans under normal and pathological conditions. J Clin Endocrinol Metab. 2010;95:2296-305 pubmed publisher
    ..Little is known, however, about how the cells expressing the enzymes are actually distributed in the adrenals under normal and pathological conditions...
  71. Lezmi S, Bencsik A, Monks E, Petit T, Baron T. First case of feline spongiform encephalopathy in a captive cheetah born in France: PrP(sc) analysis in various tissues revealed unexpected targeting of kidney and adrenal gland. Histochem Cell Biol. 2003;119:415-22 pubmed
    ..More interestingly, unusual PrP(sc )deposits were observed within the zona fasciculata/reticularis of the adrenal gland and within some glomeruli of the kidney raising the question of possible PrP(..
  72. Chang L, Tseng Y, Lin Y, Wun W, Wang P. Effects of S-petasin on corticosterone release in rats. Chin J Physiol. 2002;45:137-42 pubmed
    ..reduction of basal and ACTH-stimulated release of corticosterone from the enzymatically dispersed rat zona fasciculata-reticularis (ZFR) cells in a dose-dependent manner...
  73. Gomora J, Enyeart J. Dual pharmacological properties of a cyclic AMP-sensitive potassium channel. J Pharmacol Exp Ther. 1999;290:266-75 pubmed
    Bovine adrenal zona fasciculata cells express a novel K+ current (IAC) that sets the resting potential while it couples adrenocorticotropin and angiotensin II receptors to membrane depolarization and cortisol secretion...
  74. Takeda Y, Miyamori I, Iki K, Yoneda T, Takeda R. Biosynthetic pathway of 19-noraldosterone in isolated rat glomerulosa cells. J Steroid Biochem Mol Biol. 1994;49:69-71 pubmed
    ..These three mineralocorticoids were not detected in FCs. The results demonstrate that 19-noraldo is synthesized in GCs and then undergoes further metabolism...
  75. Feher I. [The effect of a one-time, continous administration of a stressor (alcohol) on the secretory activity of the glomerular and fascicular zone of the adrenal cortex]. Med Pregl. 1991;44:296-302 pubmed
    ..It is assumed that the serotoninergic system of the CNS essentially influences the function of the H-H-C system, but not the basal activity as well...
  76. Cymeryng C, Dada L, Colonna C, Mendez C, Podesta E. Effects of L-arginine in rat adrenal cells: involvement of nitric oxide synthase. Endocrinology. 1999;140:2962-7 pubmed
    The effects of L-arginine on corticosterone production, cGMP, and nitrite levels were examined in zona fasciculata adrenal cells. L-Arginine significantly decreased both basal and ACTH-stimulated corticosterone production...
  77. Fang V, Juan C, Hsu Y, Won J, Ho L. The stimulatory effect of vasoactive intestinal peptides on the cortisol production of guinea pig Zona fasciculata cells: an extra-ACTH regulatory model of the adrenocortical function. Chin J Physiol. 2001;44:73-9 pubmed
    ..intestinal peptide (VIP) on cortisol production was studied in a primary culture enriched with guinea pig Zona Fasciculata (ZF) cells. In ZF cells, VIP stimulates cortisol secretion and enhances the steroidogenic action of ACTH...
  78. Enyeart J, Boyd R, Enyeart J. ACTH and AII differentially stimulate steroid hormone orphan receptor mRNAs in adrenal cortical cells. Mol Cell Endocrinol. 1996;124:97-110 pubmed
    ..The dual function of these peptide hormones as mediators of development and corticosteroid synthesis could necessitate the presence of separate, parallel signaling pathways...
  79. Liu H, Enyeart J, Enyeart J. Potent inhibition of native TREK-1 K+ channels by selected dihydropyridine Ca2+ channel antagonists. J Pharmacol Exp Ther. 2007;323:39-48 pubmed
    Bovine adrenal zona fasciculata (AZF) cells express bTREK-1 background K+ channels that set the resting membrane potential...
  80. Nishikawa T, Suematsu S, Matsuzawa Y, Saito J, Omura M. Guanosine triphosphate can directly regulate cortisol production by activating Ca(2+)-messenger systems in bovine adrenal fasciculata cells. Endocr J. 2016;63:77-85 pubmed publisher
    ..In conclusion, it can be postulated that GTP-induced steroid secretion in bovine adrenal fasciculata cells is under paracrine or autocrine control. ..
  81. Dupré Aucouturier S, Penhoat A, Rougier O, Bilbaut A. ACTH-induced Cl(-) current in bovine adrenocortical cells: correlation with cortisol secretion. Am J Physiol Endocrinol Metab. 2002;282:E355-65 pubmed
    ACTH has been shown to depolarize bovine adrenal zona fasciculata cells by inhibiting a K(+) current. The effects of this hormone on such cells have been reexamined using perforated and standard patch recording methods...
  82. Kelly S, McKenna T, Young L. Coregulatory protein-orphan nuclear receptor interactions in the human adrenal cortex. J Endocrinol. 2005;186:33-42 pubmed
    ..SRC-1) and silencing mediator for retinoid and thyroid hormones (SMRT), were found to be expressed in the zona fasciculata and reticularis in the human adrenal cortex, but were largely absent from the zona glomerulosa...
  83. Buzueva I, Shmerling M, Filiushina E, Markel A, Iakobson G. [Structure of the adrenal gland in rat strain with hereditary stress-induced arterial hypertension nursed by Wistar dams]. Morfologiia. 2002;122:66-9 pubmed
    ..In the adrenal zona glomerulosa and zona fasciculata of 3-week-old rats of the first group parenchymal-stromal ratio and the average volume of adrenocorticocytes ..
  84. Chang L, Alfred Wun W, Wang P. Effects and mechanisms of nonylphenol on corticosterone release in rat zona fasciculata-reticularis cells. Toxicol Sci. 2010;118:411-9 pubmed publisher
    ..e., adrenal cortical hormone. However, the effects and action mechanisms of NP on rat adrenal zona fasciculata-reticularis (ZFR) cells are still unclear. This study explored the effects of NP on corticosterone release...
  85. Polito A, Lorin de la Grandmaison G, Mansart A, Louiset E, Lefebvre H, Sharshar T, et al. Human and experimental septic shock are characterized by depletion of lipid droplets in the adrenals. Intensive Care Med. 2010;36:1852-8 pubmed publisher
    ..Cholesteryl ester deficiency which results in adrenal lipid store depletion has been proposed as a potential mechanism of sepsis associated adrenal insufficiency...
  86. Kashirina N. The morphological and functional basis of the new conception about the suprarenal cortex regeneration. Medicina (Kaunas). 2003;39:951-4 pubmed
    ..This cell type gradually differentiates into the typical cortical cells of zona reticularis. Stem cortical cells were found in suprarenal cortex. They did not have specific morphological signs and could synthesize nucleus DNA...
  87. Raza F, Okamoto M, Takemori H, Vinson G. Manganese superoxide dismutase activity in the rat adrenal. J Endocrinol. 2005;184:77-84 pubmed
    ..The 25 kDa MnSOD isoform was unaffected by the treatments. The results suggest that MnSOD may have a specific role in the steroidogenic function of the fasciculata/reticularis of the rat adrenal, but not in that of the glomerulosa...
  88. Woods A, Judd A. Interleukin-4 increases cortisol release and decreases adrenal androgen release from bovine adrenal cells. Domest Anim Endocrinol. 2008;34:372-82 pubmed
    ..Because communication between the immune and endocrine systems is important in inflammatory conditions, IL-4 may play a role in coordinating the adrenal response to inflammatory stress...
  89. Malendowicz L, Neri G, Markowska A, Hochol A, Nussdorfer G, Majchrzak M. Effects of leptin and leptin fragments on steroid secretion of freshly dispersed rat adrenocortical cells. J Steroid Biochem Mol Biol. 2003;87:265-8 pubmed
    ..and 10(-6)M) on aldosterone and corticosterone secretion from freshly dispersed rat zona glomerulosa (ZG) and zona fasciculata-reticularis (ZF/R) cells...
  90. Dupré Aucouturier S, Penhoat A, Rougier O, Bilbaut A. Volume-sensitive Cl- current in bovine adrenocortical cells: comparison with the ACTH-induced Cl- current. J Membr Biol. 2004;199:99-111 pubmed
    In a previous study performed on zona fasciculata (ZF) cells isolated from calf adrenal glands, we identified an ACTH-induced Cl- current involved in cell membrane depolarization...