chromaffin paraganglia

Summary

Summary: Small bodies containing chromaffin cells occurring outside of the adrenal medulla, most commonly near the sympathetic ganglia and in organs such as the kidney, liver, heart and gonads.

Top Publications

  1. Matturri L, Migliarini A, Rossi L. [Changes in the cardiovascular chemo-baroreceptors as a possible basis for sudden infant death (SIDS)]. Pathologica. 1992;84:467-71 pubmed
    ..The role of aorticopulmonary paraganglia, as baro-chemoreceptors, in the cardiovascular regulation, has been anatomical substrate for explaining a sudden infant death, according to a multifactorial theory of SIDS...
  2. Galan Rodriguez B, Del Marco A, Flores J, Ramiro Fuentes S, Gonzalez Aparicio R, Tunez I, et al. Grafts of extra-adrenal chromaffin cells as aggregates show better survival rate and regenerative effects on parkinsonian rats than dispersed cell grafts. Neurobiol Dis. 2008;29:529-42 pubmed publisher
    ..Finally, nigral degeneration and partial degeneration of ventral tegmental area were not precluded after transplantation, indicating that the trophic effect of grafts was local within the host striatum...
  3. Porzionato A, Macchi V, Parenti A, Matturri L, De Caro R. Peripheral chemoreceptors: postnatal development and cytochemical findings in Sudden Infant Death Syndrome. Histol Histopathol. 2008;23:351-65 pubmed publisher
    ..b>Chromaffin paraganglia show increased expression of nitric oxide synthase and neuropeptides, and increased innervation...
  4. Howarth S, Griffiths D, Varma M. Paraganglion of the prostate gland: an uncommon mimic of prostate cancer in needle biopsies. Histopathology. 2005;47:114-5 pubmed
  5. Linazasoro G. [Stem cells: solution to the problem of transplants in Parkinson's disease?]. Neurologia. 2003;18:74-100 pubmed
    ..Finally, ethical controversies should be carefully managed. Neurología 2003;18(2):74-100..
  6. Motavkin P, Andreeva N, Eliseeva E. [Nitric oxide formation by chromaffinocytes of respiratory system and its importance for catecholamine exocytosis]. Morfologiia. 2002;121:80-3 pubmed
    ..It is concluded that NO is involved in the mechanism of catecholamine release...
  7. Jögi A, Øra I, Nilsson H, Lindeheim A, Makino Y, Poellinger L, et al. Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype. Proc Natl Acad Sci U S A. 2002;99:7021-6 pubmed
    ..Thus, hypoxia apparently causes dedifferentiation both in vitro and in vivo. These findings suggest a novel mechanism for selection of highly malignant tumor cells with stem-cell characteristics...
  8. Kihara H, Terai H, Kihara Y, Kihara T, Takahashi H, Kosuda A, et al. [Pheochromocytoma of the left retroperitoneal paraganglion associated with torsade de pointes: a case report]. J Cardiol. 1997;30:37-44 pubmed
    ..The diagnosis was pheochromocytoma in the left retroperitoneal paraganglion. The tumor which was removed measured 70 x 65 x 60 mm in size. Microscopic examination revealed the characteristic patterns of pheochromocytoma...
  9. Honma K. Paraganglia of the urinary bladder. An autopsy study. Zentralbl Pathol. 1994;139:465-9 pubmed
    ..Middle-aged and elderly subjects suffering from chronic lung diseases exhibit a statistically significant increase in the incidence of PUB, suggesting chronic hypoxemia as a stimulant for the persistence of PUB...
  10. Hedborg F, Ohlsson R, Sandstedt B, Grimelius L, Hoehner J, Pahlman S. IGF2 expression is a marker for paraganglionic/SIF cell differentiation in neuroblastoma. Am J Pathol. 1995;146:833-47 pubmed
    ..Furthermore, since paraganglia/SIF cells undergo postnatal involution, the same cellular mechanism may be responsible for spontaneous regression in infant neuroblastoma...

Detail Information

Publications36

  1. Matturri L, Migliarini A, Rossi L. [Changes in the cardiovascular chemo-baroreceptors as a possible basis for sudden infant death (SIDS)]. Pathologica. 1992;84:467-71 pubmed
    ..The role of aorticopulmonary paraganglia, as baro-chemoreceptors, in the cardiovascular regulation, has been anatomical substrate for explaining a sudden infant death, according to a multifactorial theory of SIDS...
  2. Galan Rodriguez B, Del Marco A, Flores J, Ramiro Fuentes S, Gonzalez Aparicio R, Tunez I, et al. Grafts of extra-adrenal chromaffin cells as aggregates show better survival rate and regenerative effects on parkinsonian rats than dispersed cell grafts. Neurobiol Dis. 2008;29:529-42 pubmed publisher
    ..Finally, nigral degeneration and partial degeneration of ventral tegmental area were not precluded after transplantation, indicating that the trophic effect of grafts was local within the host striatum...
  3. Porzionato A, Macchi V, Parenti A, Matturri L, De Caro R. Peripheral chemoreceptors: postnatal development and cytochemical findings in Sudden Infant Death Syndrome. Histol Histopathol. 2008;23:351-65 pubmed publisher
    ..b>Chromaffin paraganglia show increased expression of nitric oxide synthase and neuropeptides, and increased innervation...
  4. Howarth S, Griffiths D, Varma M. Paraganglion of the prostate gland: an uncommon mimic of prostate cancer in needle biopsies. Histopathology. 2005;47:114-5 pubmed
  5. Linazasoro G. [Stem cells: solution to the problem of transplants in Parkinson's disease?]. Neurologia. 2003;18:74-100 pubmed
    ..Finally, ethical controversies should be carefully managed. Neurología 2003;18(2):74-100..
  6. Motavkin P, Andreeva N, Eliseeva E. [Nitric oxide formation by chromaffinocytes of respiratory system and its importance for catecholamine exocytosis]. Morfologiia. 2002;121:80-3 pubmed
    ..It is concluded that NO is involved in the mechanism of catecholamine release...
  7. Jögi A, Øra I, Nilsson H, Lindeheim A, Makino Y, Poellinger L, et al. Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype. Proc Natl Acad Sci U S A. 2002;99:7021-6 pubmed
    ..Thus, hypoxia apparently causes dedifferentiation both in vitro and in vivo. These findings suggest a novel mechanism for selection of highly malignant tumor cells with stem-cell characteristics...
  8. Kihara H, Terai H, Kihara Y, Kihara T, Takahashi H, Kosuda A, et al. [Pheochromocytoma of the left retroperitoneal paraganglion associated with torsade de pointes: a case report]. J Cardiol. 1997;30:37-44 pubmed
    ..The diagnosis was pheochromocytoma in the left retroperitoneal paraganglion. The tumor which was removed measured 70 x 65 x 60 mm in size. Microscopic examination revealed the characteristic patterns of pheochromocytoma...
  9. Honma K. Paraganglia of the urinary bladder. An autopsy study. Zentralbl Pathol. 1994;139:465-9 pubmed
    ..Middle-aged and elderly subjects suffering from chronic lung diseases exhibit a statistically significant increase in the incidence of PUB, suggesting chronic hypoxemia as a stimulant for the persistence of PUB...
  10. Hedborg F, Ohlsson R, Sandstedt B, Grimelius L, Hoehner J, Pahlman S. IGF2 expression is a marker for paraganglionic/SIF cell differentiation in neuroblastoma. Am J Pathol. 1995;146:833-47 pubmed
    ..Furthermore, since paraganglia/SIF cells undergo postnatal involution, the same cellular mechanism may be responsible for spontaneous regression in infant neuroblastoma...
  11. Hervonen A, Linnoila I, Tainio H, Vaalasti A, Mascorro J. Immunohistochemical evidence for the occurrence of vasoactive intestinal polypeptide (VIP)-containing nerve fibres in human fetal abdominal paraganglia. J Anat. 1985;143:121-8 pubmed
    ..It may be suggested that VIP-containing nerves could regulate a secretory response from fetal human abdominal paraganglia...
  12. Gobbi H, Barbosa A, Nogueira J, Polak J, Teixeira V, Almeida H. Enkephalin- and serotonin-like immunoreactivity in the aortico-pulmonary paraganglia of the white-belly opossum Didelphis albiventris (Marsupialia). Histochem J. 1992;24:110-4 pubmed
    ..The hypothesis is raised that these peptides and serotonin, besides catecholamines, produced by these paraganglia may play a physiological role in the functions of the cardiovascular system of the white-belly opossum...
  13. Kummer W, Neuhuber W. Vagal paraganglia of the rat. J Electron Microsc Tech. 1989;12:343-55 pubmed
    ..This peculiar arrangement of paraganglionic parenchyma and arterial blood supply may be one of the reasons for the different physiological properties of vagal and carotid arterial chemoreceptors...
  14. Mauri M, Mingazzini P, Sisti S, Montironi R, Scarpelli M. Histomorphometric and morphologic studies of the carotid body and aortic paragangliomas. Appl Pathol. 1989;7:310-7 pubmed
    ..However, subgroups on the basis of morphological features (architectural patterns and degree of intensity of argyrophilia), site of origin, and clinical behaviour (metastases and recurrences) show no morphometric differences...
  15. Gobbi H, Barbosa A, Teixeira V, Almeida H. Immunocytochemical identification of neuroendocrine markers in human cardiac paraganglion-like structures. Histochemistry. 1991;95:337-40 pubmed
    ..Its is also possible that they originate functioning and non-functioning tumours...
  16. Guy L, Begin L, Oligny L, Brock G, Chevalier S, Aprikian A. Searching for an intrinsic neuroendocrine cell in the kidney. An immunohistochemical study of the fetal, infantile and adult kidney. Pathol Res Pract. 1999;195:25-30 pubmed
    ..Otherwise, no neuroendocrine cell was detected within the renal parenchyma or hilum, therefore not validating/sustaining the aforementioned hypothesis in the pathogenesis of renal carcinoid tumor...
  17. Hervás Abad E, Páramo Fernández C, Casteràs Román A, Hernández De Alonso E, Fajar Rodríguez L, Ramírez Muñoz L, et al. [High percentage of adrenergic symptoms in extraadrenal chromaffin tumors]. Rev Clin Esp. 2010;210:163-7 pubmed publisher
    ..Descriptive retrospective study of 14 patients with paragangliomas (PGL) attended in the University Hospital of Vigo (Pontevedra) during the last 25 years to evaluating their characteristics and neuroendocrine potential...
  18. Chaturvedi R, Shukla S, Seth K, Agrawal A. Zuckerkandl's organ improves long-term survival and function of neural stem cell derived dopaminergic neurons in Parkinsonian rats. Exp Neurol. 2008;210:608-23 pubmed publisher
  19. Lu K, Chien C, Chau Y. Effects of 5-hydroxydopamine and 6-hydroxydopamine on the ultrastructure of type I cells in paraganglia of the rat recurrent laryngeal nerve. Arch Histol Cytol. 1992;55:57-65 pubmed
  20. Perry S, Gilmour K, Vulesevic B, McNeill B, Chew S, Ip Y. Circulating catecholamines and cardiorespiratory responses in hypoxic lungfish (Protopterus dolloi): a comparison of aquatic and aerial hypoxia. Physiol Biochem Zool. 2005;78:325-34 pubmed
    ..Thus, unlike in exclusively water-breathing teleosts, P. dolloi would appear to rely solely on internal/airway O2 chemoreceptors for initiating catecholamine secretion and cardiorespiratory responses...
  21. Villanueva I, Piñón M, Quevedo Corona L, Martínez Olivares R, Racotta R. Epinephrine and dopamine colocalization with norepinephrine in various peripheral tissues: guanethidine effects. Life Sci. 2003;73:1645-53 pubmed
    ..Hepatic-vagus paraganglia contain all the catecholamines in relatively high amounts in nonneural cells, and Gnt treatment raises DA levels without affecting the other amines...
  22. Ahonen M. Neurofilament immunoreactivity and acetylcholinesterase activity in the developing sympathetic tissues of the rat. Histochemistry. 1991;96:467-78 pubmed
  23. Kawabata K. Paraganglia of the gallbladder: a report of two cases with an immunohistochemical study. Pathol Res Pract. 1999;195:781-6 pubmed
    ..These structures, which slightly resembled adrenal medulla or retroperitoneal paraganglia, might be misunderstood as an infiltration of primary or metastatic carcinoma into the subserosal connective tissue...
  24. Yokoi H, Tsuruo Y, Ishimura K. Steroid 5alpha-reductase type 1 immunolocalized in the rat peripheral nervous system and paraganglia. Histochem J. 1998;30:731-9 pubmed
    ..These findings suggest that 5alpha-reductase is widely distributed in glial cells, and that, in addition to myelination, 5alpha-reduced steroids play a role in some glial functions in the peripheral nervous system...
  25. Ostrowski M, Wheeler T. Paraganglia of the prostate. Location, frequency, and differentiation from prostatic adenocarcinoma. Am J Surg Pathol. 1994;18:412-20 pubmed
    ..Recognition of prostatic paraganglia, with appropriate immunohistochemical stains when necessary, will obviate the possibility of confusing these structures with prostatic adenocarcinoma...
  26. Wikström L, Rokaeus A, Fried G. Perinatal development of galanin-like immunoreactivity in chromaffin tissues of the rabbit. Regul Pept. 1993;44:297-303 pubmed
    ..The high content of GAL-LI in the PGGL at birth may reflect an enhanced synthesis associated with birth...
  27. Hofmann H, Seidl K, Unsicker K. Development and plasticity of adrenal chromaffin cells: cues based on in vitro studies. J Electron Microsc Tech. 1989;12:397-407 pubmed
  28. Fried G, Wikstrom M, Lagercrantz H. Postnatal development of catecholamines and response to hypoxia in adrenals and paraganglia of rabbits. J Auton Nerv Syst. 1988;24:65-70 pubmed
    ..After hypoxia at day 1, the noradrenaline levels decreased in paraganglia but not in adrenals, while adrenaline levels did not significantly change in either organ...
  29. Plenat F, Leroux P, Floquet J, Floquet A. Intra and juxtavagal paraganglia: a topographical, histochemical, and ultrastructural study in the human. Anat Rec. 1988;221:743-53 pubmed
    ..In addition to paraganglia, single, isolated neurons or true micro-ganglia were always found along the trunk and branches of the vagus nerve when multiple sections were examined...
  30. Kondo H. The cytoplasmic matrix of the adrenal chromaffin cells of rats under normal and stressed conditions. J Electron Microsc Tech. 1989;12:356-63 pubmed
    ..The significance of the gel-sol transition of the cytoplasmic matrix in relation to the secretory mechanism was discussed...
  31. Moftaquir Handaj A, Jafari S, Boutroy M. Neonatal catecholamine content of adrenal and extra-adrenal chromaffin tissue after prenatal exposure to dexamethasone. Pediatr Res. 1999;45:60-5 pubmed
  32. Trifaro J, Tang R, Novas M. Monolayer co-culture of rat heart cells and bovine adrenal chromaffin paraneurons. In Vitro Cell Dev Biol. 1990;26:335-47 pubmed
  33. Souto M, Mariani M. Immunochemical localization of chromaffin cells during the embryogenic migration. Biocell. 1996;20:179-84 pubmed
    ..Serotonin(5HT) immunoreactivity is localized from 17 prenatal days in several groups of the paraganglionic cells where they could be a modulator for chromaffin differentiation...
  34. Hansen J, Bing G, Notter M, Kordower J, Fiandaca M, Gash D. Adrenal chromaffin cells as transplants in animal models of Parkinson's disease. J Electron Microsc Tech. 1989;12:308-15 pubmed
    ..An overview of the role of the chromaffin cell in this exciting and clinically important arena is briefly reviewed, with an emphasis on the fine structure of implanted chromaffin cells...
  35. Dixon J, Gosling J, Canning D, Gearhart J. An immunohistochemical study of human postnatal paraganglia associated with the urinary bladder. J Anat. 1992;181 ( Pt 3):431-6 pubmed
    ..This combination of immunostaining confirms them as a rich source of noradrenaline...
  36. Ohtsuki Y, Ochi K, Okada Y, Lee G, Furihata M. Multiple minute nests of incidentally detected paraganglionic cells associated with urothelial carcinoma of the urinary bladder in a 73-year-old woman. Med Mol Morphol. 2008;41:62-5 pubmed publisher
    ..This is the first case of PGCs associated with UC in the human urinary bladder in the English literature...