neural tube


Summary: A tube of ectodermal tissue in an embryo that will give rise to the CENTRAL NERVOUS SYSTEM, including the SPINAL CORD and the BRAIN. Lumen within the neural tube is called neural canal which gives rise to the central canal of the spinal cord and the ventricles of the brain. For malformation of the neural tube, see NEURAL TUBE DEFECTS.

Top Publications

  1. Albuixech Crespo B, López Blanch L, Burguera D, Maeso I, Sánchez Arrones L, Moreno Bravo J, et al. Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain. PLoS Biol. 2017;15:e2001573 pubmed publisher
    ..The resulting genoarchitectonic model revealed that the amphioxus incipient neural tube is unexpectedly complex, consisting of several AP and DV molecular partitions...
  2. Toriyama M, Toriyama M, Wallingford J, Finnell R. Folate-dependent methylation of septins governs ciliogenesis during neural tube closure. FASEB J. 2017;31:3622-3635 pubmed publisher
    Periconception maternal folic acid (vitamin B9) supplementation can reduce the prevalence of neural tube defects (NTDs), although just how folates benefit the developing embryo and promote closing of the neural tube and other ..
  3. Zagorski M, Tabata Y, Brandenberg N, Lutolf M, Tkacik G, Bollenbach T, et al. Decoding of position in the developing neural tube from antiparallel morphogen gradients. Science. 2017;356:1379-1383 pubmed publisher
    Like many developing tissues, the vertebrate neural tube is patterned by antiparallel morphogen gradients...
  4. Hoelzl M, Heby Henricson K, Gerling M, Dias J, Kuiper R, Trünkle C, et al. Differential requirement of SUFU in tissue development discovered in a hypomorphic mouse model. Dev Biol. 2017;429:132-146 pubmed publisher
    ..Interestingly, no apparent changes in the dorso-ventral patterning of the neural tube at E9.0 could be seen...
  5. Prager A, Hagenlocher C, Ott T, Schambony A, Feistel K. hmmr mediates anterior neural tube closure and morphogenesis in the frog Xenopus. Dev Biol. 2017;430:188-201 pubmed publisher
    ..of morphogenetic processes which drive elevation and apposition of the neural folds and their fusion into a neural tube. The newly formed tube gives rise to the brain in anterior regions and continues to develop into the spinal ..
  6. Wang C, Li J, Meng Q, Wang B. Three Tctn proteins are functionally conserved in the regulation of neural tube patterning and Gli3 processing but not ciliogenesis and Hedgehog signaling in the mouse. Dev Biol. 2017;430:156-165 pubmed publisher
    ..this, Tctn3 mutant mice exhibit holoprosencephaly and randomized heart looping and lack the floor plate in the neural tube, the phenotypes similar to those of Tctn1 and Tctn2 mutants...
  7. Lacomme M, Medevielle F, Bourbon H, Thierion E, Kleinjan D, Roussat M, et al. A long range distal enhancer controls temporal fine-tuning of PAX6 expression in neuronal precursors. Dev Biol. 2018;436:94-107 pubmed publisher
    ..In the neural tube PAX6 expression is initiated in neural progenitors through the positive action of retinoic acid signaling and ..
  8. Green S, Uy B, Bronner M. Ancient evolutionary origin of vertebrate enteric neurons from trunk-derived neural crest. Nature. 2017;544:88-91 pubmed publisher
    ..Rather, labelling with the lipophilic dye DiI shows that late-migrating cells, originating from the trunk neural tube and associated with nerve fibres, differentiate into neurons within the gut wall and typhlosole...
  9. Baumholtz A, Simard A, Nikolopoulou E, Oosenbrug M, Collins M, Piontek A, et al. Claudins are essential for cell shape changes and convergent extension movements during neural tube closure. Dev Biol. 2017;428:25-38 pubmed publisher
    During neural tube closure, regulated changes at the level of individual cells are translated into large-scale morphogenetic movements to facilitate conversion of the flat neural plate into a closed tube...

More Information


  1. York J, Yuan T, Zehnder K, McCauley D. Lamprey neural crest migration is Snail-dependent and occurs without a differential shift in cadherin expression. Dev Biol. 2017;428:176-187 pubmed publisher
    ..crest, and requires the transcription factor Snail for proper expression, yet CadIA is never expressed in the neural tube during neural crest development, suggesting that differential regulation of classical cadherin expression is ..
  2. de Castro S, Hirst C, Savery D, Rolo A, Lickert H, Andersen B, et al. Neural tube closure depends on expression of Grainyhead-like 3 in multiple tissues. Dev Biol. 2018;435:130-137 pubmed publisher
    Failure of neural tube closure leads to neural tube defects (NTDs), common congenital abnormalities in humans...