embryo

Summary

Alias: embryos

Webpages

  1. embryology lecture notes
    www1.indstate.edu/thcme/duong/EMBRYOL.html
  2. ans 431: early embryonic development
    www.siu.edu/~tw3a/431emb.htm
  3. embryology glossary
    www.suu.edu/sci/biology/classes/embryology/Quiz/guide.html
  4. biology 33: the human placenta
    www.sccs.swarthmore.edu/users/98/amita/embryo.html
  5. assembling blood vessels from embryonic stem cells : umdnj research
    www.umdnj.edu/home2web/research/publications/spring08/8.htm
  6. ossm vertebrate zoology: class reptilia
    www.ossm.edu/biology/reptilia.htm
  7. mrc harwell | selected references
    www.har.mrc.ac.uk/training/cryocourse/notes/ref.html
  8. fertility facts - the south texas fertility center - south texas women's health center - department of obstetrics & gynecology - school of medicine - ut health science center
    www.uthscsa.edu/stwhc/fertility/patinfo.asp
  9. linking mutations in mice to human birth defects
    www.pitt.edu/~biohome/Dept/Frame/linkingmutations.htm
  10. reproductive medicine associates of new jersey
    www.rmanj.com/glossary.html

Research Grants

  1. Gene Regulation And Function Of Cartilage
    Yoshihiko Yamada; Fiscal Year: 2006
  2. Gene Expression At The Beginning Of Mammalian Developmen
    MELVIN L DE PAMPHILIS; Fiscal Year: 2006
  3. Cell Recognition And Synapse Formation
    Marshall W Nirenberg; Fiscal Year: 2006
  4. Dynamics of Secretory Membrane Trafficking, Sorting and
    JENNIFER A LIPPINCOTT-SCHWARTZ; Fiscal Year: 2006
  5. Genetic Analysis Of Morphogenetic Mechanism During Mouse
    Yuji Mishina; Fiscal Year: 2006
  6. Mechanisms of Vertebrate Gastrulation
    Benjamin Feldman; Fiscal Year: 2006
  7. STAT Regulation by Polycystin-1
    Thomas Weimbs; Fiscal Year: 2008
  8. Cell and Molecular Basis for Congenital Heart Disease
    Cecilia W Lo; Fiscal Year: 2006
  9. MOLECULAR PATHOGENESIS OF CHROMOSOME 16 INVERSION INHUMA
    Pu Paul Liu; Fiscal Year: 2006
  10. EMBRYONIC DOPAMINE CELL IMPLANTS FOR PARKINSONISM
    Curt R Freed; Fiscal Year: 2005

Publications

  1. Effects of Emx2 inactivation on the gene expression profile of neural precursors
    Rosaria M R Gangemi
    National Institute for Cancer Research, 16132 Genova, Italy
    Eur J Neurosci 23:325-34
  2. Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid
    R Verani
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Rome, Italy
    J Neurochem 100:242-50
  3. Generation of structures formed by lens and retinal cells differentiating from embryonic stem cells
    Mariko Hirano
    Department of Immunology, School of Life Science, Faculty of Medicine, Tottori University, Yonago, Japan
    Dev Dyn 228:664-71
  4. Neuronal lineage-specific induction of phospholipase Cepsilon expression in the developing mouse brain
    Dongmei Wu
    Division of Molecular Biology, Department of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Eur J Neurosci 17:1571-80
  5. Basic fibroblast growth factor endows dorsal telencephalic neural progenitors with the ability to differentiate into oligodendrocytes but not gamma-aminobutyric acidergic neurons
    Masahiko Abematsu
    Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
    J Neurosci Res 83:731-43
  6. Transition of mouse de novo methyltransferases expression from Dnmt3b to Dnmt3a during neural progenitor cell development
    D Watanabe
    Laboratory of Molecular Embryology, Department of Bioscience, Kitasato University School of Science, 1 15 1, Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Neuroscience 142:727-37
  7. Coexpression of Brn-3a POU protein with p53 in a population of neuronal progenitor cells is associated with differentiation and protection against apoptosis
    Chantelle D Hudson
    Medical Molecular Biology Unit, Institute of Child Health, London, United Kingdom
    J Neurosci Res 78:803-14
  8. Differential expression of Pax6 and Ngn2 between pair-generated cortical neurons
    Ayano Kawaguchi
    Laboratory for Cell Culture Development, Brain Science Institute, RIKEN, Wako, Saitama, Japan
    J Neurosci Res 78:784-95
  9. BM88 is an early marker of proliferating precursor cells that will differentiate into the neuronal lineage
    Yassemi Koutmani
    Laboratory of Cellular and Molecular Neurobiology, Hellenic Pasteur Institute, 127 Vassilissis Sofias Avenue, Athens 115 21, Greece
    Eur J Neurosci 20:2509-23
  10. Soluble CPG15 expressed during early development rescues cortical progenitors from apoptosis
    Ulrich Putz
    The Picower Center for Learning and Memory, Departments of Brain and Cognitive Sciences and Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Neurosci 8:322-31

Scientific Experts

Detail Information

Webpages124 found, 30 most recent shown here

  1. embryology lecture notes
    www1.indstate.edu/thcme/duong/EMBRYOL.html
  2. ans 431: early embryonic development
    www.siu.edu/~tw3a/431emb.htm
  3. embryology glossary
    www.suu.edu/sci/biology/classes/embryology/Quiz/guide.html
  4. biology 33: the human placenta
    www.sccs.swarthmore.edu/users/98/amita/embryo.html
  5. assembling blood vessels from embryonic stem cells : umdnj research
    www.umdnj.edu/home2web/research/publications/spring08/8.htm
  6. ossm vertebrate zoology: class reptilia
    www.ossm.edu/biology/reptilia.htm
  7. mrc harwell | selected references
    www.har.mrc.ac.uk/training/cryocourse/notes/ref.html
  8. fertility facts - the south texas fertility center - south texas women's health center - department of obstetrics & gynecology - school of medicine - ut health science center
    www.uthscsa.edu/stwhc/fertility/patinfo.asp
  9. linking mutations in mice to human birth defects
    www.pitt.edu/~biohome/Dept/Frame/linkingmutations.htm
  10. reproductive medicine associates of new jersey
    www.rmanj.com/glossary.html
  11. put in that the corpus luteum is maintained by the placenta
    neuromedia.neurobio.ucla.edu/campbell/lectures/female.htm
  12. boilerplate overview: osrr - gene targeting and knockout mouse facility
    research.musc.edu/bp/osrr_gtkmf.html
  13. prof. carol warner
    www.biology.neu.edu/faculty03/warner03.html
  14. nsf reu - featured projects
    www.gwu.edu/~hhmi/reu/featuredprojects/index.html
  15. what are stem cells? (everyday mysteries: fun science facts from the library of congress
    www.loc.gov/rr/scitech/mysteries/stemcells.html
  16. amg lecture 19
    www.biochem.arizona.edu/classes/bioc471/pages/Lecture19/Lect ...
  17. colorado center for reproductive medicine - reducing incidence of multiple pregnancies with advanced fertility treatments
    www.colocrm.com/reducing_multiples.htm
  18. dr. ross's vertebrate embryology course home page
    www.cbu.edu/~aross/embhome.htm
  19. an introduction to pregnancy
    faculty.etsu.edu/currie/pregnancy.htm
  20. valproic acid
    zygote.swarthmore.edu/env13.html
  21. ossm vertebrate zoology lab notes
    www.ossm.edu/biology/vzlbn.htm
  22. ziyi's research page
    elab.genetics.uiowa.edu/MEMBERPAGES/Ziyi/Ziyiresearch.htm
  23. fetal development
    www.cpmc.org/services/pregnancy/information/fetal_developmen ...
  24. eu s.o.m. dept. of cellbiology :: krishna bhat, ph.d
    www.cellbio.emory.edu/research_labs_bhat.cfm
  25. influence of isoflavones on porcine embryonic development and embryonic... (illini porknet) — university of illinois extension
    www.traill.uiuc.edu/porknet/paperDisplay.cfm?ContentID=82
  26. human reproduction and development
    www.biology.buffalo.edu/courses/bio531/lecture8.html
  27. amg hw7
    www.biochem.arizona.edu/classes/bioc471/pages/Homework7.html
  28. ectopic pregnancy - high-risk pregnancy - health library - children's hospital of the king's daughters
    www.chkd.com/High_Risk_Pregnancy/ectopic.asp
  29. developmental genetics ig workshop 2008
    www.genetics.iastate.edu/ws08.html

Research Grants62

  1. Gene Regulation And Function Of Cartilage
    Yoshihiko Yamada; Fiscal Year: 2006
    ..The early morphogenetic event of mouse tooth development occurs in the embryo by invagination of the oral ectoderm into the underlying neural crest-derived mesenchyme, which later ..
  2. Gene Expression At The Beginning Of Mammalian Developmen
    MELVIN L DE PAMPHILIS; Fiscal Year: 2006
    ..DkkL1 mRNA is found in preimplantation mouse embryos and in developing neural tissue, but in adults it is found primarily in the testes...
  3. Cell Recognition And Synapse Formation
    Marshall W Nirenberg; Fiscal Year: 2006
    ..from this laboratory showed that the vnd/NK-2 gene is expressed in 11 neuroblasts per hemisegment in Drosophila embryos. A -5.3 to -2...
  4. Dynamics of Secretory Membrane Trafficking, Sorting and
    JENNIFER A LIPPINCOTT-SCHWARTZ; Fiscal Year: 2006
    ..of peroxisomes; and the foundation for compartmentalization of endomembranes in the developing Drosophilia embryo. In addition to these topics, a major effort in the lab has been to develop new fluorescence microscopy techniques...
  5. Genetic Analysis Of Morphogenetic Mechanism During Mouse
    Yuji Mishina; Fiscal Year: 2006
    Developmental process of vertebrate embryos is regulated, at least in part, by secreting molecules such as growth factors...
  6. Mechanisms of Vertebrate Gastrulation
    Benjamin Feldman; Fiscal Year: 2006
    ..During vertebrate gastrulation, embryos undergo dramatic morphogenesis, beginning as a simple assembly of homogenous cells, and emerging as highly ..
  7. STAT Regulation by Polycystin-1
    Thomas Weimbs; Fiscal Year: 2008
    ..of the PC1 tail stimulates proliferation in MDCK cells and results in renal cyst-formation in zebrafish embryos. Furthermore, MDCK cells respond to interleukin-4 (IL4) and IL13 similar to immune cells in that they activate ..
  8. Cell and Molecular Basis for Congenital Heart Disease
    Cecilia W Lo; Fiscal Year: 2006
    ..The analysis of the normal human embryos will be followed by analysis of abnormal human embryos with a variety of congenital defects...
  9. MOLECULAR PATHOGENESIS OF CHROMOSOME 16 INVERSION INHUMA
    Pu Paul Liu; Fiscal Year: 2006
    ..mouse knock-in strategy, we showed that the fusion gene Cbfb-MYH11 dominantly represses Runx/Cbfb function, since embryos heterozygous for the knocked-in fusion gene had similar phenotypes as the Runx1 or Cbfb null embryos (block of ..
  10. EMBRYONIC DOPAMINE CELL IMPLANTS FOR PARKINSONISM
    Curt R Freed; Fiscal Year: 2005
    ..Transplanted patients received cultured mesencephalic tissue from four embryos along four 30 to 40 mm needle tracts bilaterally in the putamen...
  11. Cellular, Molecular And Genetic Analysis Of Neural Fate
    Ajay B Chitnis; Fiscal Year: 2006
    ..Early neurogenesis occurs in three longitudinal columns within the caudal neural plate in zebrafish and Xenopus embryos. The patterning mechanisms that delineate neurogenic and non-neurogenic domains are poorly understood, but ..
  12. Specification And Patterning During Vertebrate Organogen
    Brant M Weinstein; Fiscal Year: 2006
    ..lymphatic endothelial cells, making it possible for us to visualize the blood vessel formation in intact, living embryos. We have developed methodologies for long-term multiphoton confocal timelapse imaging of vascular development in ..
  13. IMPROVING COMMUNICATION WITH IVF PATIENTS ABOUT RISKS SUCH AS MULTIPLE BIRTHS
    Linda M Frazier; Fiscal Year: 2008
    ..The chance of having a multi-fetal pregnancy is lower when fewer embryos are transferred to the uterus during IVF, but the couple may need to pay for more cycles of treatment to ..
  14. Genes Involved in Cellular Differ.n and Proliferation
    Ilan Kirsch; Fiscal Year: 2004
    ..The SIL knockout mouse dies during embryonic development between E8.5-10.53. Sil null embryos 7.5 to 8.5 days old are reduced in size with delayed development and regional apoptosis...
  15. MEMBRANE FUSION MEDIATED BY VIRAL AND DEVELOPMENTAL PROT
    LEONID CHERNOMORDIK; Fiscal Year: 2006
    ..nuclei reside in syncytial cells that originate through programmed and stereotyped cell-cell fusions in living embryos and larvae. The transmembrane protein EFF-1 was identified using genetic screens as a C...
  16. Cell Cycle Regulation In C. elegans
    Andy Golden; Fiscal Year: 2006
    ..These first meiotic divisions are important as any errors in chromosome segregation at this stage can lead to embryos with an abnormal number of chromosomes, which would likely lead to lethality...
  17. IMPROVING COMMUNICATION WITH IVF PATIENTS ABOUT RISKS SUCH AS MULTIPLE BIRTHS
    Linda M Frazier; Fiscal Year: 2007
    ..The chance of having a multi-fetal pregnancy is lower when fewer embryos are transferred to the uterus during IVF, but the couple may need to pay for more cycles of treatment to ..
  18. Development Of Techniques To Insert Point Mutations Into
    VIKTOR E MOROZOV; Fiscal Year: 2006
    ..single stranded DNA (ssDNA), alone or in combination with other factors, into pronuclei of one celled mouse embryos. Manipulated embryos are incubated up to the blastula stage, at which point they are examined for presence of the ..
  19. Control Of Gene Expression During Development
    Judith A Kassis; Fiscal Year: 2006
    ..We will then determine the expression patterns of the proteins in embryos, and do chromatin immunoprecipitation experiments to determine whether they are bound to PREs...
  20. Molecular Mechanisms Of Myofibril Assembly And Function
    Robert Horowits; Fiscal Year: 2006
    ..N-RAP is concentrated in myofibril precursors during sarcomere assembly in cultured cardiomyocytes and early embryos. Distinct regions of N-RAP bind specific cytoskeletal proteins, and overexpression of these regions in cultured ..
  21. Phosphorylation & Function of Inhibitor-2
    David L Brautigan; Fiscal Year: 2008
    ..In Drosophila there is a single Inh2 gene that is maternally expressed in oocytes and embryos during early stages of development...
  22. Reproductive Strategies in Animal Species Emphasizing De
    STEPHEN J O'BRIEN; Fiscal Year: 2006
    ..Medicine), we are determining the conditions necessary to propagate and to genetically manipulate feline embryos and to establish feline embryonic stem (ES) and embryonic germ (EG) cells...
  23. Novel Informatics for Highly Reliable Multi-Locus Allele Calling for Embryo Scree
    Matthew Rabinowitz; Fiscal Year: 2008
    ..more than $5,000; and a couple is forced to choose between testing aneuploidy, which afflicts roughly 40% of IVF embryos, or screening for disease-linked loci on the single cell...
  24. METALLOTHIONEIN IN REPRODUCTION AND DEVELOPMENT
    Glen K Andrews; Fiscal Year: 2002
    ..on MT gene expression in vivo and/or in vitro in mouse decidual cells, visceral endoderm, reimplantation embryos and fetal hepatocytes, b) determining the in vivo interactions of proteins with the MT-I gene promoter in ..
  25. Molecular mechanisms of cell fate specification
    Lynne M Angerer; Fiscal Year: 2006
    ..specification and patterning along the animal?vegetal (A?V) axis of the sea urchin (Strongylocentrotus purpuratus) embryo. Our major focus is to understand the gene regulatory networks and signaling pathways that specify ectodermal ..
  26. GENETIC ANALYSIS OF ZEBRAFISH EMBRYO DEVELOPMENT
    Pu Paul Liu; Fiscal Year: 2006
    ..Transparent embryos and ex vivo development allows noninvasive observations of embryonic development...
  27. Improved Implantation and Pregnancy Using Microfluidic Embryo Culture
    XIAOYUE TERRY ZHU; Fiscal Year: 2007
    ..To improve the percentage of cycles resulting in live births, the industry relies on transferring an average of 3 embryos per cycle, leading to multiple births in more than one-third of all cases, which in turn, increases risks to both ..
  28. Studies on a Novel RNA that Promotes Heart Development
    Larry F Lemanski; Fiscal Year: 2006
    ..Ambystoma mexicanum, is an intriguing model for studying early heart development, because homozygous embryos (c/c) form hearts that are deficient in tropomyosin, lack organized myofibrils, and fail to beat...
  29. Embryonic regulation of GnRH neuron migration and function
    David J Kozlowski; Fiscal Year: 2008
    ..In part, this is because GnRH neurons are few in number and inaccessible in most vertebrate embryos or the intact adult brain...
  30. POSITIONAL CLONING OF THE MEN1 GENE
    Settara Chandrasekharappa; Fiscal Year: 2006
    ..Reduction of menin by injections of antisense oligonucleotides (morpholino derivatives) in embryos allowed us to evaluate the role of menin in zebrafish hematopoiesis; the reduction did not appear to adversely ..
  31. Targeted Manipulation of the Zebrafish Genome through Homologous Recombination
    Brian Ciruna; Fiscal Year: 2008
    ..Zebrafish embryos are optically clear and easily manipulated, permitting sub-cellular biomedical imaging studies in living tissue...
  32. Membrane mechanisms of cytokinesis in Drosophila embryos
    John C Sisson; Fiscal Year: 2006
    ..In cleavage stage Drosophila embryos the formation of cellularization furrows, which are special cytokinesis furrows, depends on Golgi-derived ..
  33. Membrane mechanisms of cytokinesis in Drosophila embryos
    John C Sisson; Fiscal Year: 2007
    ..In cleavage stage Drosophila embryos the formation of cellularization furrows, which are special cytokinesis furrows, depends on Golgi-derived ..
  34. DEVELOPMENT OF HEMATOPOIETIC STEM CELLS
    Roland Jurecic; Fiscal Year: 2004
    ..BEA is based on microinjection of purified HSC into mouse preimplantation embryos (blastocysts), similar to ES cell technology...
  35. SAGE Analysis of Murine Oocyte Maturation
    Charlotte E Farin; Fiscal Year: 2004
    ..the regulation of mammalian oocyte maturation in an effort to improve methodologies for the production of embryos in vitro...
  36. STRATEGIES FOR PRIMATE TRANSGENESIS
    Thaddeus G Golos; Fiscal Year: 2003
    ..Specific Aim 1 is to deliver transgenes to rhesus monkey preimplantation embryos with Epstein-Barr Virus (EBV)-based and retrovirus-based vectors...
  37. GLUTS AND GLUCOSE TRANSPORT IN THE MOUSE BLASTOCYST
    Kelle H Moley; Fiscal Year: 2008
    ..Similar growth abnormalities are seen in embryos lacking autophagy proteins as well, and other recent studies suggest that basal autophagy during development is ..
  38. Identification of Genes Associated with Myoblast Fusion
    Susan M Abmayr; Fiscal Year: 2008
    ..In the embryo, two distinct populations of myoblasts appear to be involved in formation of these fibers...
  39. The role of proteoglycans in zebrafish development
    Kenneth L Kramer; Fiscal Year: 2006
    ..We use zebrafish because the early embryos are transparent, easy to manipulate, and a large number of mutants exist that aid in our analysis...
  40. Genes regulating pattern formation during embryonic deve
    Susan Mackem; Fiscal Year: 2006
    ..We are developing chromatin immunoprecipitation (ChIP) assays in embryos to enable direct identification of target promoters in vivo for T-box genes that regulate limb outgrowth...
  41. Letrozole Therapy for IVF/ET: Effects on Multiple Pregnancy and Treatment Burden
    Robert G Brzyski; Fiscal Year: 2008
    ..These regimens facilitate the creation of multiple embryos, which promotes the transfer and cryopreservation of excess embryos...
  42. Body Plan Formation in Early Mouse Embryo
    Yusuke Marikawa; Fiscal Year: 2004
    ..will use lineage-specific molecular markers to identify the differentiation of these two distinct cell types in embryos treated with various inhibitors of the cytoskeleton, membrane trafficking and cell adhesion...
  43. Hh signaling in the zebrafish forebrain and pituitary
    Rolf O Karlstrom; Fiscal Year: 2008
    ..The loss of GH is the most common single endocrine deficiency in humans, occurring in 1 in 4000 embryos. We previously showed that this range of pituitary defects also occurs in zebrafish Hh pathway mutants, providing ..
  44. Letrozole Therapy for IVF/ET: Effects on Multiple Pregnancy and Treatment Burden
    Robert G Brzyski; Fiscal Year: 2007
    ..These regimens facilitate the creation of multiple embryos, which promotes the transfer and cryopreservation of excess embryos...
  45. Mechanisms of Neural Crest Differentiation during Craniofacial Development
    Vivian M Lee; Fiscal Year: 2008
    DESCRIPTION (provided by applicant): Formation of the vertebrate embryo involves an intricate series of cell movements, cell proliferation, and differentiation...
  46. Hh signaling in the zebrafish forebrain and pituitary
    Rolf O Karlstrom; Fiscal Year: 2007
    ..The loss of GH is the most common single endocrine deficiency in humans, occurring in 1 in 4000 embryos. We previously showed that this range of pituitary defects also occurs in zebrafish Hh pathway mutants, providing ..
  47. Ethical Issues Regarding Women in Health Research
    Anne D Lyerly; Fiscal Year: 2008
    ..exists about how decisions regarding such research specifically affect those women from whose gametes the embryos were created and their partners and families...
  48. Transgenesis-Ready Mice with Tn5 Transposase
    JOANNE SM EBESU; Fiscal Year: 2007
    ..with injections of the Tn5 protein (Tn5p) DNA complex into the cytoplasm or pronuclei of fertilized single cell embryos. As ICSI and ROSI are cumbersome and difficult techniques to master for most laboratories, the failure of simple ..
  49. IGF Induced Toxicity in Preimplantation Embryos
    Kelle H Moley; Fiscal Year: 2007
    ..Can direct exposure of the embryo to the insulin-sensitizing agent metformin reverse the "insulin resistance" in embryos exposed to high IGF-1...
  50. Arachidonate Products and CYP1A in Dioxin Toxicity
    Arleen B Rifkind; Fiscal Year: 2008
    ..which sense and antisense CYP1A gene constructs in retroviral vectors will be targeted to liver or heart in chick embryos at early stages of development and the effects examined at a later stages...
  51. Spindle Formation and Function in Oocytes and Early Embryos
    Keith E Latham; Fiscal Year: 2008
    ..This inheritance is removed during cloning, and thus lacking in SCNT embryos, but is present in ECNT embryos. The deficiency in SCNT embryos likely contributes to the poor success of cloning...
  52. Spindle Formation and Function in Oocytes and Early Embryos
    Keith E Latham; Fiscal Year: 2007
    ..This inheritance is removed during cloning, and thus lacking in SCNT embryos, but is present in ECNT embryos. The deficiency in SCNT embryos likely contributes to the poor success of cloning...
  53. Core--Transgenic and Knockout Mouse
    Loren J Field; Fiscal Year: 2007
    ..The core then harvests single cell embryos, microinjects the embryos with the DNA construct, transplants the microinjected embryos into pseudo-pregnant ..
  54. Comprehensive aneuploidy diagnosis in single cells
    Nury Steuerwald; Fiscal Year: 2005
    ..To improve pregnancy rates many IVF clinics replace multiple embryos each cycle...
  55. Dietary Cysteine:Conceptal Response to Oxidative Stress
    Craig Harris; Fiscal Year: 2002
    ..Demonstrated differences in the rates of new glutathione synthesis in the developing embryo and its extra-embryonic membranes suggest that the availability of free cysteine, as the rate-limiting precursor ..
  56. Role of the cdx homeobox genes in the regulation of wt1 and nephron development
    Alan J Davidson; Fiscal Year: 2008
    ..This code is disrupted in embryos deficient in the homeobox transcription factor genes cdx1a and cdx4, which act as master regulators of the hox ..
  57. Characterizing Mammalian Embryonic polyA Binding Protein
    EMRE UTKU SELI; Fiscal Year: 2008
    ..Although a cytoplasmic PABP (PABP1) has long been known, it is not expressed in oocytes and early embryos. The candidate has recently identified an oocyte and embryo-specific PABP in Xenopus named ePAB...
  58. Characterizing Mammalian Embryonic polyA Binding Protein
    Emre Seli; Fiscal Year: 2007
    ..Although a cytoplasmic PABP (PABP1) has long been known, it is not expressed in oocytes and early embryos. The candidate has recently identified an oocyte and embryo-specific PABP in Xenopus named ePAB...
  59. Mechanisms of Neural Crest Differentiation during Craniofacial Development
    Vivian M Lee; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): Formation of the vertebrate embryo involves an intricate series of cell movements, cell proliferation, and differentiation...
  60. CSHL Cell and Developmental Biology of Xenopus
    TERRI I GRODZICKER; Fiscal Year: 2007
    ..This course provides extensive laboratory exposure to the biology and manipulation of embryos from the frogs Xenopus laevis and Xenopus tropicalis...
  61. CSHL Cell and Developmental Biology of Xenopus
    TERRI I GRODZICKER; Fiscal Year: 2008
    ..This course provides extensive laboratory exposure to the biology and manipulation of embryos from the frogs Xenopus laevis and Xenopus tropicalis...

Publications62

  1. Effects of Emx2 inactivation on the gene expression profile of neural precursors
    Rosaria M R Gangemi
    National Institute for Cancer Research, 16132 Genova, Italy
    Eur J Neurosci 23:325-34
    ..action, we compared the expression profile of cultured neurospheres derived from wild-type and Emx2-null mouse embryos. The differential expression of several genes was also confirmed by semiquantitative RT-PCR, real-time PCR and ..
  2. Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid
    R Verani
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Rome, Italy
    J Neurochem 100:242-50
    ..These data suggest that induction of Dkk-1 and the ensuing inhibition of the canonical Wnt pathway is required for neural differentiation of ES cells...
  3. Generation of structures formed by lens and retinal cells differentiating from embryonic stem cells
    Mariko Hirano
    Department of Immunology, School of Life Science, Faculty of Medicine, Tottori University, Yonago, Japan
    Dev Dyn 228:664-71
    Embryonic stem cells have the potential to give rise to all cell lineages when introduced into the early embryo. They also give rise to a limited number of different cell types in vitro in specialized culture systems...
  4. Neuronal lineage-specific induction of phospholipase Cepsilon expression in the developing mouse brain
    Dongmei Wu
    Division of Molecular Biology, Department of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Eur J Neurosci 17:1571-80
    ..These results suggest that the induction of phospholipase Cepsilon expression may be a specific event associated with the commitment of the neural precursor cells to the neuronal lineage...
  5. Basic fibroblast growth factor endows dorsal telencephalic neural progenitors with the ability to differentiate into oligodendrocytes but not gamma-aminobutyric acidergic neurons
    Masahiko Abematsu
    Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
    J Neurosci Res 83:731-43
    ....
  6. Transition of mouse de novo methyltransferases expression from Dnmt3b to Dnmt3a during neural progenitor cell development
    D Watanabe
    Laboratory of Molecular Embryology, Department of Bioscience, Kitasato University School of Science, 1 15 1, Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Neuroscience 142:727-37
    ..The coordinated expression of de novo methyltransferases from Dnmt3b to Dnmt3a suggests conserved mechanisms of de novo methylation of the genome and different functions for Dnmt3b and Dnmt3a during progenitor cell development...
  7. Coexpression of Brn-3a POU protein with p53 in a population of neuronal progenitor cells is associated with differentiation and protection against apoptosis
    Chantelle D Hudson
    Medical Molecular Biology Unit, Institute of Child Health, London, United Kingdom
    J Neurosci Res 78:803-14
    ..Functional effects of Brn-3a/p53 coexpression were analyzed in NCC cultured from Brn-3a -/- embryos, which showed significantly increased apoptosis upon induction of p53 compared with wild-type NCC, suggesting ..
  8. Differential expression of Pax6 and Ngn2 between pair-generated cortical neurons
    Ayano Kawaguchi
    Laboratory for Cell Culture Development, Brain Science Institute, RIKEN, Wako, Saitama, Japan
    J Neurosci Res 78:784-95
    ..We suggest that pair progenitor cells contribute to the generation of neuronal diversity through cell-intrinsic heterogeneity and asymmetric division...
  9. BM88 is an early marker of proliferating precursor cells that will differentiate into the neuronal lineage
    Yassemi Koutmani
    Laboratory of Cellular and Molecular Neurobiology, Hellenic Pasteur Institute, 127 Vassilissis Sofias Avenue, Athens 115 21, Greece
    Eur J Neurosci 20:2509-23
    ..Our data show an interesting correlation between BM88 expression and the progression of progenitor cells towards neuronal differentiation during the neurogenic interval...
  10. Soluble CPG15 expressed during early development rescues cortical progenitors from apoptosis
    Ulrich Putz
    The Picower Center for Learning and Memory, Departments of Brain and Cognitive Sciences and Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Neurosci 8:322-31
    ..CPG15 expressed during mammalian forebrain morphogenesis may help balance neuronal number by countering apoptosis in specific neuroblasts subpopulations, thus influencing final brain size and shape...
  11. The chemokine stromal cell-derived factor-1 regulates the migration of sensory neuron progenitors
    Abdelhak Belmadani
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Neurosci 25:3995-4003
    ..In mouse embryos, we observed expression of the chemokine (CXC motif) receptor 4 (CXCR4) by neural crest cells migrating from the ..
  12. The extracellular matrix glycoprotein Tenascin-C is expressed by oligodendrocyte precursor cells and required for the regulation of maturation rate, survival and responsiveness to platelet-derived growth factor
    Jeremy Garwood
    LNDR, CNRS 5, rue Blaise Pascal, 67084 Strasbourg Cedex, France
    Eur J Neurosci 20:2524-40
    ..These were present in equivalent proportions to those found in wild-type neurospheres but displayed enhanced myelin membrane formation...
  13. Involvement of CD45 in central nervous system myelination
    Jin Nakahara
    Department of Anatomy, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Neurosci Lett 379:116-21
    ..Our findings suggest that CD45 is a key phosphatase involved in OPC differentiation and provide a preliminary explanation for the previously reported CD45 mutations observed in some multiple sclerosis (MS) patients...
  14. Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system
    Jian Feng
    Department of Human Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    J Neurosci Res 79:734-46
    ..Our data suggest that whereas Dnmt3b may be important for the early phase of neurogenesis, Dnmt3a likely plays a dual role in regulating neurogenesis prenatally and CNS maturation and function postnatally...
  15. Molecular markers of neuronal progenitors in the embryonic cerebellar anlage
    Daniver Morales
    Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York 10021 6399, USA
    J Neurosci 26:12226-36
    ..These results identify molecular pathways that offer new insights on the development of the nuclear and cortical structures of the cerebellum, as well as components of the cerebellar circuitry...
  16. Expression of steroid receptor coactivator-1 is elevated during neuronal differentiation of murine neural stem cells
    Eijun Nishihara
    Division of Neurobiology and Behavior, Department of Translational Medical Science, Course of Medical and Dental Sciences, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Brain Res 1135:22-30
    ..during the proliferation and differentiation in culture of NSCs derived from the ganglionic eminence of mouse embryos. We found that SRC-1 was rarely expressed in proliferating cells and multipotent precursors with the typical ..
  17. SRF regulates Bcl-2 expression and promotes cell survival during murine embryonic development
    Gerhard Schratt
    Interfakultäres Institut für Zellbiologie, Abteilung Molekularbiologie, Universität Tübingen, Auf der Morgenstelle, Tübingen, Germany
    EMBO J 23:1834-44
    ..Bcl-2 expression in embryoid bodies (EBs) and inappropriate apoptosis in both EBs and pregastrulation mouse embryos. Thus, our data from genetic and cellular studies uncover SRF-regulated Bcl-2 expression as a novel mechanism ..
  18. Voltage-gated K+ current: a marker for apoptosis in differentiating neuronal progenitor cells?
    Marusa Hribar
    Department of Basic Neurosciences, Centre Médical Universitaire, 1, rue Michel Servet, 1211 Geneva 4, Switzerland
    Eur J Neurosci 20:635-48
    ..Recordings of this current revealed that apoptosis at early stages of neuronal differentiation occurred in two phases that did not exhibit similar dependence on the proapoptotic protein Bax and that probably used different pathways...
  19. Loss of arginase I results in increased proliferation of neural stem cells
    Sara G Becker Catania
    Edward Hines Jr Veterans Administration Hospital, Hines, Illinois, USA
    J Neurosci Res 84:735-46
    ..The consequence of these changes may contribute to the differential phenotypes of KO vs. WT cells. It appears that AI may play an important and unanticipated role in growth and development of NSCs...
  20. The Lim homeobox gene Lhx2 is required for olfactory sensory neuron identity
    Asa Kolterud
    Department of Molecular Biology, Umeå University, Umeå, SE901 87, Sweden
    Development 131:5319-26
    ..We show that progenitors and neurons express the LIM-homeobox gene Lhx2 and that neurons in Lhx2-null mutant embryos do not diversify into subpopulations expressing different OR genes and other region-restricted genes such as Nqo1 ..
  21. Directed differentiation of telencephalic precursors from embryonic stem cells
    Kiichi Watanabe
    Organogenesis and Neurogenesis Group, Center for Developmental Biology, RIKEN, Kobe 650-0047, Japan
    Nat Neurosci 8:288-96
    ..Thus, in the absence of caudalizing signals, floating aggregates of ES cells generate naive telencephalic precursors that acquire subregional identities by responding to extracellular patterning signals...
  22. Endogenous activation of mGlu5 metabotropic glutamate receptors supports self-renewal of cultured mouse embryonic stem cells
    Irene Cappuccio
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
    Neuropharmacology 49:196-205
    ..These data support a critical role for mGlu receptors in early development showing that mGlu5 receptors are expressed by ES cells and their activation sustains ES cell self-renewal in culture...
  23. Bone morphogenetic proteins produced by cells within embryoid bodies inhibit ventral directed differentiation by Sonic Hedgehog
    Jared L Sterneckert
    Institute for Cell Engineering, BRB 772, 733 North Broadway, Baltimore, MD 21205, USA
    Cloning Stem Cells 7:27-34
    ..Shh more potently directed ventral differentiation when combined with the BMP inhibitor Noggin. Further, when BMP7 was added, the ability of Shh to direct ventral differentiation was further mitigated...
  24. ABCA2 is a marker of neural progenitors and neuronal subsets in the adult rodent brain
    Cyril Broccardo
    Centre d Immunologie de Marseille Luminy INSERM CNRS, Université de la Méditerranée Marseille, France
    J Neurochem 97:345-55
    ..Considering that the latter are targets of Alzheimer's lesions, these data provide a new rationale to explore the neuropathological consequences of ABCA2 functional dysregulations...
  25. A subset of ES-cell-derived neural cells marked by gene targeting
    Hai-Qing Xian
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Stem Cells 21:41-9
    ..The strategy may have general applicability, since other neural lineages can be marked in an analogous manner...
  26. Maternal administration of thalidomide or valproic acid causes abnormal serotonergic neurons in the offspring: implication for pathogenesis of autism
    Kaoru Miyazaki
    Neurobiology Laboratory, Institute of Basic Medical Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-city, Ibaraki 305-8575, Japan
    Int J Dev Neurosci 23:287-97
    ..These results indicate that disruption of early serotonergic neuronal development might be involved in the etiology of autism...
  27. Ontogeny and plasticity of adult hippocampal neural stem cells
    Maya Sieber Blum
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisc 53226, USA
    Dev Neurosci 25:273-8
    ..melanocytes (pigment cells) and smooth muscle cells when cocultured with neural crest cells from quail embryos. Neural crest cell-generated stimuli have a short-range of action and are recognized across species...
  28. Nuclear and chromatin reorganization in the MHC-Oct3/4 locus at developmental phases of embryonic stem cell differentiation
    Takahiro Aoto
    Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, The 21st Century COE, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Dev Biol 298:354-67
    ..These findings provide insights into the molecular basis of global nuclear reorganization and euchromatic gene silencing in differentiation through the spatiotemporal order of epigenetic controls...
  29. Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype
    Cecile Martinat
    Department of Pathology and Neurology, Center for Neurobiology and Behavior, and Taub Institute, Columbia University, College of Physicians and Surgeons 15 403, 630 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:2874-9
    ..Here we show that Nurr1 and Pitx3 cooperatively promote terminal maturation to the midbrain DA neuron phenotype in murine and human ES cell cultures...
  30. Developmental potential of defined neural progenitors derived from mouse embryonic stem cells
    Nicolas Plachta
    Biozentrum, University of Basel, Klingelbergstrasse 50/70, 4056 Basel, Switzerland
    Development 131:5449-56
    The developmental potential of a uniform population of neural progenitors was tested by implanting them into chick embryos. These cells were generated from retinoic acid-treated mouse embryonic stem (ES) cells, and were used to replace a ..
  31. Midkine, a heparin-binding growth factor, is expressed in neural precursor cells and promotes their growth
    Peng Zou
    Department of Biochemistry, Center for Neurological Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Neurochem 99:1470-9
    ..These results indicate that midkine is involved in the growth of neural precursor cells and suggest that the interaction with heparan sulfate proteoglycans is important in midkine action to these cells...
  32. Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates
    Leping Cheng
    The Dana Farber Cancer Institute, and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Nat Neurosci 7:510-7
    ..Finally, excess GABA-mediated inhibition caused dysfunction of central respiratory circuits in Tlx3 mutant mice...
  33. Definitive hematopoiesis requires the mixed-lineage leukemia gene
    Patricia Ernst
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, Harvard Medical School, Departments of Pathology and Medicine, Harvard Medical School, Boston, MA 02115 USA
    Dev Cell 6:437-43
    ..Similarly, in vitro differentiation of B cells required MLL. In chimeric embryos, Mll-deficient cells failed to contribute to fetal liver hematopoietic stem cell/progenitor populations...
  34. Murine embryonic EGF-responsive ventral mesencephalic neurospheres display distinct regional specification and promote survival of dopaminergic neurons
    David Moses
    Howard Florey Institute of Experimental Physiology and Medicine, The University of Melbourne, Victoria 3010, Australia
    Exp Neurol 199:209-21
    ..These data may have implications in the treatment of Parkinson's disease...
  35. Generation of embryonic stem cells and transgenic mice expressing green fluorescence protein in midbrain dopaminergic neurons
    Suling Zhao
    Institute for Stem Cell Research, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh, United Kingdom, EH9 3JQ, UK
    Eur J Neurosci 19:1133-40
    ..Live primary DA neurons can be isolated by fluorescence-activated cell sorting from these transgenic mouse embryos. In culture, Pitx3-GFP is coexpressed in a proportion of ES-derived DA neurons...
  36. Ubiquitin C-terminal hydrolase L1 regulates the morphology of neural progenitor cells and modulates their differentiation
    Mikako Sakurai
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 187 8502, Japan
    J Cell Sci 119:162-71
    ..These results suggest that UCH-L1 spatially mediates and enhances neurogenesis in the embryonic brain by regulating progenitor cell morphology...
  37. FGF-4 regulates neural progenitor cell proliferation and neuronal differentiation
    Nobuyoshi Kosaka
    Department of Biology, School of Education, Waseda University, Tokyo, Japan
    FASEB J 20:1484-5
    ..These findings suggest that FGF-4 has an ability to promote neural stem cell proliferation and neuronal differentiation in the postnatal brain...
  38. Stage- and site-specific DNA demethylation during neural cell development from embryonic stem cells
    Koji Shimozaki
    Laboratory of Animal Molecular Technology, Research and Education Center for Genetic Information, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    J Neurochem 93:432-9
    ..Taken together, these results demonstrate that the astrocyte gene-specific cytidine-demethylation is programmed when neural progenitors from pluripotent cells are committed to a neural lineage that is capable of producing astrocytes...
  39. Cell cycle and developmental regulations of replication factors in mouse embryonic stem cells
    Hiroko Fujii-Yamamoto
    Department of Cell Biology, Tokyo Metropolitan Institute of Medical Science, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8613, Japan
    J Biol Chem 280:12976-87
    ..Furthermore, they are rapidly down-regulated upon induction of differentiation of ES cells. The significance of these findings is discussed in relation to the unusual proliferative properties of ES cells in an undifferentiated state...
  40. Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitors
    Shengguo Li
    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 679 Hoes Lane, Piscataway, NJ 08854 USA
    Neuron 43:795-807
    ..Our data suggest a model in which Foxn4 cooperates with other key retinogenic factors to mediate the multipotent differentiation of retinal progenitors...
  41. Deregulation of dorsoventral patterning by FGF confers trilineage differentiation capacity on CNS stem cells in vitro
    Limor Gabay
    Division of Biology 216-76, California Institute of Technology, Pasadena, CA 91125, USA
    Neuron 40:485-99
    ....
  42. The transcription factor Bhlhb4 is required for rod bipolar cell maturation
    Debra E Bramblett
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 43:779-93
    ..Other retinal cell populations including photoreceptors were unaltered. The timing of RB cell depletion in the Bhlhb4(-/-) mouse suggests that Bhlhb4 is essential for RB cell maturation...
  43. Differentiation of mouse embryonic stem cells into a defined neuronal lineage
    Miriam Bibel
    Friedrich Miescher Institute, CH-4058 Basel, Switzerland
    Nat Neurosci 7:1003-9
    ..As they do in vivo, these cells went on to generate neurons with remarkably uniform biochemical and electrophysiological characteristics...
  44. Nestin expression is lost in a neural stem cell line through a mechanism involving the proteasome and Notch signalling
    Karen Mellodew
    Department of Neuroscience, Institute of Psychiatry, PO39, 1 Windsor Walk, Denmark Hill, London, UK
    Brain Res Dev Brain Res 151:13-23
    ..We also show that nestin loss is regulated by Notch, and mediated by cell contact...
  45. Isolation and characterization of neural precursor cells from the Sox1-GFP reporter mouse
    Perrine Barraud
    Wallenberg Neuroscience Center, BMC A11, Section of Neurobiology, and Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund, University, SE-221 84 Lund, Sweden
    Eur J Neurosci 22:1555-69
    ..Thus, not all Sox1-GFP cells possess the same capacity for neuronal differentiation in vivo...
  46. Migrating postmitotic neural precursor cells in the ventricular zone extend apical processes and form adherens junctions near the ventricle in the developing spinal cord
    Yasuko Minaki
    KAN Research Institute Inc. Science Center Build. 3, Kyoto-Research Park, 93 Chudoji-Awata-cho, Shimogyo-ku, Kyoto 600-8815, Japan
    Neurosci Res 52:250-62
    ....
  47. Culture method for the induction of neurospheres from mouse embryonic stem cells by coculture with PA6 stromal cells
    Hideomi Kitajima
    Department of Neurosurgery, Division of Neuroscience, Graduate School of Medicine, Gifu University, Gifu, Japan
    J Neurosci Res 80:467-74
    ..These results suggested that neurosphere could be generated from ES cells by coculturing with PA6, and that these cells resembled neural stem cells derived from mouse fetal brain tissue...
  48. Direct cell-cell contact required for neurotrophic effect of chromaffin cells on neural progenitor cells
    Michael A Schumm
    The Miami Project to Cure Paralysis, School of Medicine, University of Miami, Lois Pope LIFE Center, 1095 NW 14th Terrace (R-48, Miami, FL 33136, USA
    Brain Res Dev Brain Res 146:1-13
    ....
  49. Neural stem and progenitor cells in nestin-GFP transgenic mice
    John L Mignone
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Comp Neurol 469:311-24
    ....
  50. Characterization of glycoconjugate antigens in mouse embryonic neural precursor cells
    Makoto Yanagisawa
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Neurochem 95:1311-20
    ..Based on this observation, we identified beta1 integrin as one of the SSEA-1 carrier glycoproteins. Our data thus provide insights into the functional role of certain glycoconjugate antigens in NPCs during neural development...
  51. Preferential differentiation of neural progenitor cells into the glial lineage through gp130 signaling in N-methyl-D-aspartate-treated retinas
    Yuki Mawatari
    Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, 1-1-1 Honjo, Kumamoto 860-8556, Japan
    Brain Res 1055:7-14
    ..1 +/- 6.0%, P = 0.04, Mann-Whitney U test). Preferential differentiation of NPCs into the glial lineage is induced through gp130 signaling in NMDA-treated eyes...
  52. Neurogenesis in Talpha-1 tubulin transgenic mice during development and after injury
    Turhan Coksaygan
    Gerontology Research Center, Stem Cell Biology Unit Laboratory of Neuroscience, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Room 4E02, Baltimore, MD 21224, USA
    Exp Neurol 197:475-85
    ....
  53. Prospective characterization of neural stem cells by flow cytometry analysis using a combination of surface markers
    Masako Nagato
    Department of Pediatrics, Faculty of Medicine, Kyoto University, Kyoto, Japan
    J Neurosci Res 80:456-66
    ..These results indicate the usefulness of syndecan-1, Notch-1, and integrin-beta1 as NSC markers...
  54. A cell-autonomous requirement for the cell cycle regulatory protein, Rb, in neuronal migration
    Kerry L Ferguson
    Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    EMBO J 24:4381-91
    ..These results revealed a cell-autonomous role for Rb in regulating the tangential migration of cortical interneurons. Taken together, we reveal a novel requirement for the cell cycle protein, Rb, in the regulation of neuronal migration...
  55. Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells
    Yiping Yan
    Department of Anatomy, University of Wisconsin-Madison, 1500 Highland Avenue, Madison, Wisconsin 53705, USA
    Stem Cells 23:781-90
    ..They may thus provide a renewable source of functional human DA neurons for drug screening and development of sustainable therapeutics for disorders affecting the DA system...
  56. Transplantation of motoneuron-enriched neural cells derived from mouse embryonic stem cells improves motor function of hemiplegic mice
    Shunmei Chiba
    Department of Immunology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki 216-8511, Japan
    Cell Transplant 12:457-68
    ..Our study suggests that motoneurons can be induced from ES cells, and ES cells become virtually an unlimited source of cells for experimental and clinical neural cell transplantation...
  57. Innervation of stem cell-derived neurons into auditory epithelia of mice
    Masahiro Matsumoto
    Department of Otolaryngology, Head and Neck Surgery, Kyoto University, Graduate School of Medicine, Kyoto, Japan
    Neuroreport 16:787-90
    ....