herpes simplex encephalitis

Summary

Summary: An acute (or rarely chronic) inflammatory process of the brain caused by SIMPLEXVIRUS infections which may be fatal. The majority of infections are caused by human herpesvirus 1 (HERPESVIRUS 1, HUMAN) and less often by human herpesvirus 2 (HERPESVIRUS 2, HUMAN). Clinical manifestations include FEVER; HEADACHE; SEIZURES; HALLUCINATIONS; behavioral alterations; APHASIA; hemiparesis; and COMA. Pathologically, the condition is marked by a hemorrhagic necrosis involving the medial and inferior TEMPORAL LOBE and orbital regions of the FRONTAL LOBE. (From Adams et al., Principles of Neurology, 6th ed, pp751-4)

Top Publications

  1. pmc Herpes simplex encephalitis
    P G E Kennedy
    J Neurol Neurosurg Psychiatry 73:237-8. 2002
  2. ncbi Herpes simplex infections of the nervous system
    J Richard Baringer
    Department of Neurology, University of Utah Health Sciences Center, 50 North Medical Drive, Salt Lake City, UT 84132, USA
    Neurol Clin 26:657-74, viii. 2008
  3. ncbi Herpes simplex encephalitis: diagnostic problems and late relapse
    Xavier De Tiège
    Department of Paediatric Neurology, Hopital Cochin Saint Vincent de Paul, Paris, France
    Dev Med Child Neurol 48:60-3. 2006
  4. ncbi Re-evaluating the diagnostic methods in herpes simplex encephalitis
    Amer Al-Shekhlee
    The Neurological Institute, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 44145, USA
    Herpes 13:17-9. 2006
  5. ncbi Appropriate use of polymerase chain reaction for detection of herpes simplex virus 2 in cerebrospinal fluid of patients at an inner-city hospital
    Nelia Afonso
    Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Diagn Microbiol Infect Dis 57:309-13. 2007
  6. ncbi TLR3 deficiency in patients with herpes simplex encephalitis
    Shen Ying Zhang
    Human Genetics of Infectious Diseases, Institut National de la Sante et de la Recherche Medicale INSERM, U550, Faculty Necker, Paris 75015, France
    Science 317:1522-7. 2007
  7. pmc Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis
    Rebeca Pérez de Diego
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Inserm U980, Necker Medical School, Paris, France
    Immunity 33:400-11. 2010
  8. ncbi The chemokine CCL5 is essential for leukocyte recruitment in a model of severe Herpes simplex encephalitis
    Márcia Carvalho Vilela
    Departamento de Clinica Medica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Ann N Y Acad Sci 1153:256-63. 2009
  9. ncbi Exacerbation of herpes simplex encephalitis after successful treatment with acyclovir
    Y Ito
    Department of Pediatrics, Nagoya University School of Medicine, Nagoya 466 8550, Japan
    Clin Infect Dis 30:185-7. 2000
  10. ncbi Coexistence of Alzheimer disease neuropathology with herpes simplex encephalitis
    F J Denaro
    Department of Biology, The Dixon Science Research Center, Morgan State University, and Institute of Human Virology, Animal Models Division, Cold Spring Lane, Baltimore, MD 21251, USA
    Cell Mol Biol (Noisy-le-grand) 49:1233-40. 2003

Detail Information

Publications209 found, 100 shown here

  1. pmc Herpes simplex encephalitis
    P G E Kennedy
    J Neurol Neurosurg Psychiatry 73:237-8. 2002
  2. ncbi Herpes simplex infections of the nervous system
    J Richard Baringer
    Department of Neurology, University of Utah Health Sciences Center, 50 North Medical Drive, Salt Lake City, UT 84132, USA
    Neurol Clin 26:657-74, viii. 2008
    ..Physicians need to develop an increased awareness of the early signs and symptoms of the presentation of HSVE, and of the imperative for early treatment...
  3. ncbi Herpes simplex encephalitis: diagnostic problems and late relapse
    Xavier De Tiège
    Department of Paediatric Neurology, Hopital Cochin Saint Vincent de Paul, Paris, France
    Dev Med Child Neurol 48:60-3. 2006
    ..Delayed intrathecal synthesis of specific anti-HSV antibodies was found on day 26 and confirmed herpes simplex encephalitis (HSE) diagnosis...
  4. ncbi Re-evaluating the diagnostic methods in herpes simplex encephalitis
    Amer Al-Shekhlee
    The Neurological Institute, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 44145, USA
    Herpes 13:17-9. 2006
    Several methods are used in clinical practice to investigate herpes simplex encephalitis (HSE), including electroencephalography (EEG) and polymerase chain reaction (PCR) of the viral genome in cerebrospinal fluid...
  5. ncbi Appropriate use of polymerase chain reaction for detection of herpes simplex virus 2 in cerebrospinal fluid of patients at an inner-city hospital
    Nelia Afonso
    Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Diagn Microbiol Infect Dis 57:309-13. 2007
    ..PCR testing for HSV-2 in CSF at inner-city hospitals can be greatly reduced by the application of these parameters...
  6. ncbi TLR3 deficiency in patients with herpes simplex encephalitis
    Shen Ying Zhang
    Human Genetics of Infectious Diseases, Institut National de la Sante et de la Recherche Medicale INSERM, U550, Faculty Necker, Paris 75015, France
    Science 317:1522-7. 2007
    ..Human TLR3 appears to be redundant in host defense to most microbes but is vital for natural immunity to HSV-1 in the CNS, which suggests that neurotropic viruses have contributed to the evolutionary maintenance of TLR3...
  7. pmc Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis
    Rebeca Pérez de Diego
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Inserm U980, Necker Medical School, Paris, France
    Immunity 33:400-11. 2010
    ..Thus, TLR3-mediated immunity against primary infection by HSV-1 in the central nervous system is critically dependent on TRAF3...
  8. ncbi The chemokine CCL5 is essential for leukocyte recruitment in a model of severe Herpes simplex encephalitis
    Márcia Carvalho Vilela
    Departamento de Clinica Medica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Ann N Y Acad Sci 1153:256-63. 2009
    ..However, blocking of CCR1 and CCR5 did not affect HSV-1 replication, suggesting that other immune mechanisms are involved in the process of infection control...
  9. ncbi Exacerbation of herpes simplex encephalitis after successful treatment with acyclovir
    Y Ito
    Department of Pediatrics, Nagoya University School of Medicine, Nagoya 466 8550, Japan
    Clin Infect Dis 30:185-7. 2000
    b>Herpes simplex encephalitis (HSE) in children sometimes exacerbates after successful treatment; yet the frequency, etiology, and clinical features of exacerbation remain unclear...
  10. ncbi Coexistence of Alzheimer disease neuropathology with herpes simplex encephalitis
    F J Denaro
    Department of Biology, The Dixon Science Research Center, Morgan State University, and Institute of Human Virology, Animal Models Division, Cold Spring Lane, Baltimore, MD 21251, USA
    Cell Mol Biol (Noisy-le-grand) 49:1233-40. 2003
    ..Such may be the case if there is reactivation of a previously undiagnosed herpes virus infection. With the development of PCR and in situ hybridization diagnosis will be simplified and more definitive...
  11. ncbi The spectrum of herpes simplex encephalitis in children
    Xavier De Tiège
    Department of Paediatric Neurology, ULB Hopital Erasme, Brussels, Belgium
    Eur J Paediatr Neurol 12:72-81. 2008
    Clinical and basic science research carried out in recent years into herpes simplex encephalitis (HSE) have shown that the concept of a "classical" picture of HSE in children is now outdated and that our current knowledge of the disease ..
  12. ncbi Category deficits and paradoxical dissociations in Alzheimer's disease and Herpes Simplex Encephalitis
    Keith R Laws
    Nottingham Trent University, UK
    J Cogn Neurosci 17:1453-9. 2005
    ..frequently accompanied by impaired semantic memory (19 patients with Alzheimer's disease and 15 with Herpes Simplex Encephalitis)...
  13. doi Serum S-100B protein levels in patients with herpes simplex encephalitis and tick-borne encephalitis--a marker of CNS damage during the initial stage of disease
    Marie Studahl
    Dept of Infectious Diseases, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    J Neurol 256:586-90. 2009
    This study was mainly aimed at the comparative analysis of serum S-100B protein in patients with herpes simplex encephalitis (HSE) and tick-borne encephalitis (TBE)...
  14. ncbi Monitoring of herpes simplex virus DNA types 1 and 2 viral load in cerebrospinal fluid by real-time PCR in patients with herpes simplex encephalitis
    Lottie Schloss
    Department of Virology, Swedish Institute for Infectious Disease Control, Solna, Sweden
    J Med Virol 81:1432-7. 2009
    ..While the quantitative PCR is more rational than a nested PCR, the quantitation of HSV genomes does not seem very useful as a prognostic marker in HSV encephalitis...
  15. pmc Herpes simplex encephalitis during treatment with tumor necrosis factor-alpha inhibitors
    Russell D Bradford
    Division of Infectious Diseases, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Clin Infect Dis 49:924-7. 2009
    ..Although TNF-alpha inhibitors have been reported to increase the risk of other infectious diseases, to our knowledge, an association between anti-TNF-alpha drugs and herpes simplex virus encephalitis has not been previously described...
  16. ncbi Acute intracerebral haematoma--an unusual presentation of herpes simplex encephalitis
    A Biswas
    Department of Neurology, Bangur Institute of Neurology, Kolkata
    J Assoc Physicians India 52:69-71. 2004
    ..The patient made an excellent recovery following a course of acyclovir. Frank intracerebral haematoma in the form of well defined mass on CT scan in patient with herpes simplex encephalitis is extremely rare.
  17. ncbi Herpes simplex virus type 1 (HSV-1)--induced retinitis following herpes simplex encephalitis: indications for brain-to-eye transmission of HSV-1
    J Maertzdorf
    Department of Virology, Erasmus University, Rotterdam, The Netherlands
    Ann Neurol 49:104-6. 2001
    b>Herpes simplex encephalitis is a severe neurological disease with high mortality and morbidity rates...
  18. ncbi Outcome of and prognostic factors for herpes simplex encephalitis in adult patients: results of a multicenter study
    Franck Raschilas
    Laboratoire de Virologie, Hopital Saint Vincent de Paul, and Service de Réanimation des Maladies Infectieuses, Hopital Bichat Claude Bernard, Paris, France
    Clin Infect Dis 35:254-60. 2002
    Management of herpes simplex encephalitis (HSE) has been considerably improved by the availability of acyclovir therapy and rapid polymerase chain reaction (PCR)-based diagnostic assays...
  19. ncbi Herpes simplex encephalitis: adolescents and adults
    Richard J Whitley
    Department of Pediatrics, Infectious Diseases, The University of Alabama at Birmingham, 1600 Seventh Avenue, CHB 303, Birmingham, AL 35233, United States
    Antiviral Res 71:141-8. 2006
    b>Herpes simplex encephalitis (HSE) remains one of the most devastating infections of the central nervous system despite available antiviral therapy. Children and adolescents account for approximately one third of all cases of HSE...
  20. doi Basal ganglia involvement in a child with herpes simplex encephalitis
    Gobinda Mondal
    Pediatric Intensive Care Unit, Department of Pediatrics, Medical College and Hospital, Kolkata, India
    Indian J Pediatr 76:749-50. 2009
    b>Herpes simplex encephalitis (HSE) is a leading cause of sporadic, nonepidemic viral encephalitis in children and adults...
  21. ncbi [Herpes simplex encephalitis in childhood]
    Hiroshi Kimura
    Department of Virology, Nagoya University Graduate School of Medicine
    Rinsho Shinkeigaku 46:958-60. 2006
    Central nervous system (CNS) infection by herpes simplex virus (HSV) in childhood consists of herpes simplex encephalitis and CNS infections in neonates...
  22. doi Atypical case of Herpes simplex encephalitis
    P Auyeung
    Intern Med J 38:294-5. 2008
  23. ncbi Herpes simplex encephalitis: MRI findings in two cases confirmed by polymerase chain reaction assay
    J W Lee
    Department of Radiology, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea
    Pediatr Radiol 31:619-23. 2001
    ..We present MRI findings of two cases of herpes simplex encephalitis (HSE) confirmed by PCR analysis, focusing on the serial changes after acyclovir therapy: gyral swelling,..
  24. ncbi Outcome of herpes simplex encephalitis in children
    Wen Bin Hsieh
    Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan
    J Microbiol Immunol Infect 40:34-8. 2007
    b>Herpes simplex encephalitis (HSE) can cause high mortality and morbidity in children. Since local data of HSE in children are rare, we performed a retrospective study to evaluate the prognostic factors and outcome of HSE in Taiwan.
  25. ncbi Herpes simplex encephalitis in a domestic rabbit (Oryctolagus cuniculus)
    P Grest
    Institute of Veterinary Pathology, University of Zurich, Zurich, 8057, Switzerland
    J Comp Pathol 126:308-11. 2002
    ..The agent was classified as HSV-1 by polymerase chain reaction analysis. This is only the second reported natural case of herpes simplex infection in a rabbit...
  26. ncbi Neurolisteriosis mimicking herpes simplex encephalitis in an immunocompromized patient
    John Protopsaltis
    Second Department of Internal Medicine, Tzanio General Hospital, Piraeus, Greece
    Scand J Infect Dis 38:825-8. 2006
    ..Nevertheless, PCR in CSF for Listeria monocytogens was positive. This case implies that Listeria might be considered in patients with clinical and imaging suspicion of herpetic encephalitis...
  27. ncbi Patients with suspected herpes simplex encephalitis: rethinking an initial negative polymerase chain reaction result
    Ana A Weil
    Viral and Rickettsial Disease Laboratory, Division of Communicable Disease Control, California Department of Health Services, Richmond, CA, 94804, USA
    Clin Infect Dis 34:1154-7. 2002
    A statewide encephalitis diagnostic project of the California State Department of Health Services found that herpes simplex virus 1 DNA may not be detectable by molecular methods early in the clinical course of herpes simplex encephalitis.
  28. ncbi A case of herpes simplex encephalitis revealed by decompressive craniectomy
    N Bayram
    Department of Pediatrics, Faculty of Medicine, Ege University, Izmir, Turkey
    Eur J Pediatr 167:821-2. 2008
    ..Her clinical signs and cerebral imaging findings were found to be compatible with herpes simplex encephalitis. In spite of prompt acyclovir administration, her consciousness deteriorated gradually...
  29. ncbi Herpes simplex encephalitis in Sweden, 1990-2001: incidence, morbidity, and mortality
    Anders Hjalmarsson
    Infectious Diseases Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
    Clin Infect Dis 45:875-80. 2007
    b>Herpes simplex encephalitis (HSE) is a devastating disease.
  30. ncbi Differential diagnosis of mesiotemporal lesions: case report of neurosyphilis
    A Vieira Santos
    Neuroradiology Department, Garcia de Orta Hospital, Almada, Portugal
    Neuroradiology 47:664-7. 2005
    We report a clinical and imaging case of suspected herpes simplex encephalitis subsequently diagnosed as neurosyphilis based on positive antibodies in the CSF...
  31. ncbi Screening for possible failure of herpes simplex virus PCR in cerebrospinal fluid for the diagnosis of herpes simplex encephalitis
    E Puchhammer-Stöckl
    Institute of Virology, University of Vienna, Vienna, Austria
    J Med Virol 64:531-6. 2001
    ..reliability of herpes simplex virus (HSV) PCR testing in cerebrospinal fluid (CSF) for the detection of herpes simplex encephalitis. This was done by examining retrospectively the clinical follow-up of a large group of patients tested ..
  32. ncbi Glycyrrhizin increases survival of mice with herpes simplex encephalitis
    T Sekizawa
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Acta Virol 45:51-4. 2001
    ..5-29.0% to 81.8-83.3%; mean values from 2 experiments) while it reduced HSV-1 replication in the brain to 45.6% of the control. These results demonstrate a stimulative effect of GR on the mouse defense system(s) against HSV-1 infection...
  33. ncbi Clinical spectrum, pitfalls in diagnosis and therapeutic implications in herpes simplex encephalitis
    S Jha
    Department of Neurology SGPGIMS, Lucknow
    J Assoc Physicians India 52:24-6. 2004
    High index of suspicion is mandatory for early diagnosis of Herpes Simplex Encephalitis (HSE), since acyclovir therapy can prevent its mortality and limit morbidity...
  34. ncbi Asymptomatic self-limiting white matter lesions in the chronic phase of herpes simplex encephalitis
    Nobuto Mitsufuji
    Department of Pediatrics, Kyoto First Red Cross Hospital, 15 749, Honmachi, Higashiyama ku, Kyoto, Japan
    Brain Dev 24:300-3. 2002
    We report a 9-month-old girl with herpes simplex encephalitis. T(2)-weighted magnetic resonance imaging (MRI) on the 8th day of illness showed increased signal intensity in the gray and white matter of the bilateral lobes, especially the ..
  35. ncbi Update on herpes simplex encephalitis
    Kenneth L Tyler
    Department of Neurology, University of Colorado Health Sciences Center, and the Neurology Service of the Denver Veterans Affairs Medical Center, Denver, CO, USA
    Rev Neurol Dis 1:169-78. 2004
    b>Herpes simplex encephalitis is the most common identified cause of sporadic viral encephalitis in the United States...
  36. ncbi Postinfectious immune-mediated encephalitis after pediatric herpes simplex encephalitis
    Xavier De Tiège
    Department of Pediatric Neurology, ULB Hôpital Erasme Brussels, Brussels, Belgium
    Brain Dev 27:304-7. 2005
    ..deterioration clinically characterized by a partial Kluver-Bucy syndrome, 1 month after the onset of herpes simplex encephalitis. This episode is unlikely due to continuation or resumption of cerebral viral replication but might be ..
  37. ncbi Herpes simplex encephalitis: children and adolescents
    Richard J Whitley
    Department of Pediatrics, The University of Alabama at Birmingham, AL, USA
    Semin Pediatr Infect Dis 16:17-23. 2005
    b>Herpes simplex encephalitis (HSE) remains one of the most devastating infections of the central nervous system despite available antiviral therapy. Children and adolescents account for approximately one third of all cases of HSE...
  38. ncbi Diffuse white matter lesions in a case of herpes simplex encephalitis
    Naohisa Ueda
    J Neurol 250:867-8. 2003
  39. ncbi Infantile herpes simplex encephalitis: diagnostic features and differentiation from non-accidental injury
    J Kurtz
    Department of Virology, John Radcliffe Hospital, Oxford OX3 9DU, UK
    J Infect 46:12-6. 2003
    ..After a baby, subsequently proven to have HSE, had initially been diagnosed as non-accidental injury (NAI), we reviewed the clinical features and radiology of infants with HSE recently diagnosed by our laboratory...
  40. ncbi Postinfectious autoimmune-mediated encephalitis eight months after herpes simplex encephalitis
    A A B Joos
    Department of Neurology, University of Freiburg, Freiburg, Germany
    Eur Neurol 50:54-6. 2003
  41. doi Traffic of leukocytes in the central nervous system is associated with chemokine up-regulation in a severe model of herpes simplex encephalitis: an intravital microscopy study
    Márcia Carvalho Vilela
    Pós Graduação em Infectologia e Medicina Tropical, Faculdade de Medicina FM, Universidade Federal de Minas Gerais UFMG, Belo Horizonte, Brazil
    Neurosci Lett 445:18-22. 2008
    ..These results corroborate the role of chemokines in leukocyte recruitment following HSV-1 infection in the central nervous system...
  42. ncbi Burden of encephalitis-associated hospitalizations in the United States, 1988-1997
    Nino Khetsuriani
    Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 35:175-82. 2002
    ..The average cost of an encephalitis-associated hospitalization, as determined by the Healthcare Cost and Utilization Project for 1997, was $28,151, for an annual national cost of hospitalization of $650 million...
  43. ncbi Progression of MRI abnormalities in herpes simplex encephalitis despite clinical improvement: natural history or disease progression?
    P Gaviani
    Neurological Clinic, Ospedale Maggiore della Carita, A Avogadro University of Eastern Piedmont, Corso Mazzini 18, I 28100 Novara, Italy
    Neurol Sci 25:104-7. 2004
    ..Imaging studies of a cohort of patients surviving PCR-confirmed HSVE are needed to determine whether this pattern is occasional or a frequent form of progression...
  44. ncbi Extra temporal involvement in herpes simplex encephalitis
    M Wasay
    Department of Medicine and Neurology, The Aga Khan University, Karachi, Pakistan
    Eur J Neurol 12:475-9. 2005
    Temporal lobe abnormalities on brain imaging have been described as strong evidence for herpes simplex encephalitis (HSE) in appropriate clinical settings. Extra temporal abnormalities are less well described in these patients...
  45. ncbi Acute and long-term alteration of chemokine mRNA expression after anti-viral and anti-inflammatory treatment in herpes simplex virus encephalitis
    Johann Sellner
    Department of Neurology, Im Neuenheimer Feld 400, Ruprecht Karls University Heidelberg, D 69120 Heidelberg, Germany
    Neurosci Lett 374:197-202. 2005
    ..This pattern was substantially altered by anti-viral and anti-inflammatory treatment. Our findings indicate a pivotal role of these chemokines in the immunopathogenesis of HSVE...
  46. doi Diffusion-weighted imaging and apparent diffusion coefficient evaluation of herpes simplex encephalitis and Japanese encephalitis
    Vijay Sawlani
    Department of Radiology, Morriston Hospital, Swansea SA6 6NL, UK
    J Neurol Sci 287:221-6. 2009
    ..imaging (DWI) and apparent diffusion coefficient (ADC) values in differentiating necrotising herpes simplex encephalitis (HSE) and non-necrotising Japanese encephalitis (JE) and (b) to correlate the ADC values with the ..
  47. pmc Antiviral therapy for herpesvirus central nervous system infections: neonatal herpes simplex virus infection, herpes simplex encephalitis, and congenital cytomegalovirus infection
    Scott H James
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233 1711, United States
    Antiviral Res 83:207-13. 2009
    ..Although advances in antiviral agents have led to improved outcomes, there is still a need for more effective treatments...
  48. ncbi Prognostic value of intrathecal antibody production and DNA viral load in cerebrospinal fluid of patients with herpes simplex encephalitis
    Anders Hjalmarsson
    Department of Medicine Solna, Infectious Diseases Unit, Karolinska Institutet, Stockholm 17176, Sweden
    J Neurol 256:1243-51. 2009
    b>Herpes simplex encephalitis is a devastating disease...
  49. ncbi Herpes simplex virus infections of the central nervous system: encephalitis and meningitis, including Mollaret's
    Kenneth L Tyler
    Department of Neurology, University of Colorado Health Sciences Center and Denver Veterans Affairs Medical Center, Denver, Colorado 80262, USA
    Herpes 11:57A-64A. 2004
    b>Herpes simplex encephalitis (HSE) is a life-threatening consequence of herpes simplex virus (HSV) infection of the central nervous system (CNS)...
  50. ncbi Herpes simplex encephalitis: some interesting presentations
    S Jha
    Department of Neurology, SGPGIMS, Lucknow, India
    Neurol India 51:399-400. 2003
    b>Herpes Simplex Encephalitis (HSE) is the most common cause of fatal viral encephalitis. A high index of suspicion is mandatory for early diagnosis and successful therapy to restrict morbidity and mortality...
  51. ncbi Diffusion-weighted MRI in herpes simplex encephalitis: a report of three cases
    W Kuker
    Department of Neuroradiology, University Hospital Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Neuroradiology 46:122-5. 2004
    ..Thus, DW-MRI may be a valuable tool for early detection and diagnosis of HSVE whereas contrast-enhanced images are indispensable after the first week...
  52. ncbi Increased presence of matrix metalloproteinases 2 and 9 in short- and long-term experimental herpes simplex virus encephalitis
    Francisco J Martinez-Torres
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Neurosci Lett 368:274-8. 2004
    ..Increased presence of MMP2 and MMP9 in chronic HSVE may contribute to ongoing damage. Inhibition of MMP2 and MMP9 might be a suitable target for therapeutic intervention...
  53. ncbi Herpes simplex encephalitis: a case report
    Maciej Jabłkowski
    Clinic for Infectious Diseases, Medical University of Łódź, Poland
    Med Sci Monit 10:CS41-5. 2004
    Despite advances in antiviral therapy over the past 2 decades, herpes simplex encephalitis (HSE) remains a serious illness with significant risk of morbidity and death...
  54. ncbi Modulation of sFas indicates apoptosis in human herpes simplex encephalitis
    Farideh Sabri
    Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
    J Neuroimmunol 171:171-6. 2006
    b>Herpes simplex encephalitis (HSE) is the most common cause of non-epidemic, acute and fatal viral encephalitis. A pronounced mortality and morbidity remains in HSE despite antiviral treatment...
  55. ncbi Herpes simplex encephalitis: an audit of the use of laboratory diagnostic tests
    J Chataway
    Departments of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
    QJM 97:325-30. 2004
    The combination of both PCR and intrathecal antibody studies is recommended to confirm or refute the diagnosis of herpes simplex encephalitis (HSE).
  56. ncbi A 12-year prospective study of childhood herpes simplex encephalitis: is there a broader spectrum of disease?
    Jorina M Elbers
    Division of Neurology, Hospital for Sick Children and University of Toronto, Toronto, Ontario, M5G 1X8, Canada
    Pediatrics 119:e399-407. 2007
    The purpose of this study was to review the experience with herpes simplex encephalitis at the Hospital for Sick Children over the past 12 years.
  57. ncbi Expression of Toll-like receptor 3 in the human cerebellar cortex in rabies, herpes simplex encephalitis, and other neurological diseases
    Alan C Jackson
    Unité de Neuroimmunologie Virale, Département de Neuroscience, Institut Pasteur, Paris, France
    J Neurovirol 12:229-34. 2006
    ..Purkinje cells were found to express TLR-3 in all cases of rabies (4 of 4) and herpes simplex encephalitis (2 of 2) as well as in cases of amyotrophic lateral sclerosis (1 of 2), stroke (1 of 2), and Alzheimer'..
  58. ncbi Herpes simplex replication and dissemination is not increased by corticosteroid treatment in a rat model of focal Herpes encephalitis
    K A Thompson
    Infectious Diseases Unit, School of Medicine, Monash University, Victoria, Australia
    J Neurovirol 6:25-32. 2000
    ..Corticosteroids could have an important role in the management of Herpes simplex encephalitis because their anti-inflammatory action reduces cerebral oedema...
  59. ncbi In vivo visualization of activated glia by [11C] (R)-PK11195-PET following herpes encephalitis reveals projected neuronal damage beyond the primary focal lesion
    A Cagnin
    MRC Cyclotron Unit, Imperial College, Faculty of Medicine, Hammersmith Hospital, UK
    Brain 124:2014-27. 2001
    ..Two patients with asymmetrical herpes simplex encephalitis were serially scanned 6 and 12 months after the acute illness using PET with [11C] (R)-PK11195, a ..
  60. ncbi Diffusion-weighted imaging findings on MRI as the sole radiographic findings in a child with proven herpes simplex encephalitis
    Makram Obeid
    Department of Pediatrics, Texas Tech University Health Sciences Center, 3601 4th St, Lubbock, TX 79430, USA
    Pediatr Radiol 37:1159-62. 2007
    We present a case of herpes simplex encephalitis in an 8-year-old girl, in whom hyperintensity was detected on diffusion-weighted imaging (DWI) while conventional MRI sequences were normal 1 week after the onset of neurological symptoms...
  61. ncbi Virological diagnosis of herpes simplex encephalitis
    A Sauerbrei
    Institute for Antiviral Chemotherapy, Friedrich Schiller University Jena, Nordhäuser Strasse 78, D 99089, Erfurt, Germany
    J Clin Virol 17:31-6. 2000
    The herpes simplex encephalitis (HSE) represents one of the most severe infectious diseases of the central nervous system. As effective antiviral drugs are available, rapid and reliable diagnosis has become important.
  62. ncbi Herpes simplex encephalitis in North West India
    A Panagariya
    Department of Neurology, SMS Medical College and Hospital, Jaipur 302004, India
    Neurol India 49:360-5. 2001
    ..diagnosis of cerebral venous thrombosis, cerebral malaria, tubercular meningitis etc, who resembled herpes simplex encephalitis (HSE), were excluded systematically with relevant investigations...
  63. ncbi La Crosse encephalitis presenting like herpes simplex encephalitis in an immunocompromised adult
    R Wurtz
    Department of Medicine, Evanston Hospital, Evanston, Illinois 60621, USA
    Clin Infect Dis 31:1113-4. 2000
    ..Because herpes simplex encephalitis (HSE) can be neurologically devastating and is treatable, timely diagnosis is important...
  64. pmc Relapsing herpes simplex encephalitis: pathological confirmation of viral reactivation
    S Yamada
    Department of Neurology, Gifu Prefectural Tajimi Hospital, Gifu, Japan
    J Neurol Neurosurg Psychiatry 74:262-4. 2003
    This case is reported to raise awareness of herpes simplex encephalitis as a persisting brain disorder...
  65. ncbi Neurosyphilis presenting as herpes simplex encephalitis
    I Szilak
    Montefiore Medical Center, Bronx, NY 10461, USA
    Clin Infect Dis 32:1108-9. 2001
    We report the case of a 55-year-old man with neurosyphilis that presented with features of herpes simplex encephalitis. Neurosyphilis is easily diagnosed and treated and should be included in the differential diagnosis of herpes simplex ..
  66. ncbi Quantitation of intrathecal antibodies in cerebrospinal fluid of subacute sclerosing panencephalitis, herpes simplex encephalitis and multiple sclerosis: discrimination between microorganism-driven and polyspecific immune response
    C Jacobi
    Neurochemistry Laboratory, University of Gottingen, Robert Koch Str 40, D 37075 Gottingen, Germany
    J Neuroimmunol 187:139-46. 2007
    ..for HSV or measles has about 20- to 60-fold higher values in virus-caused antibody synthesis in acute herpes simplex encephalitis (mean HSV-F(S)=8.9%) or subacute sclerosing panencephalitis (mean measles-F(S)=18...
  67. pmc Herpes simplex encephalitis: involvement of apolipoprotein E genotype
    W R Lin
    Molecular Neurobiology Laboratory, Department of Optometry and Neuroscience, UMIST, Manchester M60 1QD, UK
    J Neurol Neurosurg Psychiatry 70:117-9. 2001
    ..Whether a specific allele of the gene is involved in susceptibility to another disorder caused by HSV1-herpes simplex encephalitis (HSE)-has now been investigated...
  68. ncbi Experimental herpes simplex virus encephalitis: inhibition of the expression of inducible nitric oxide synthase in mouse brain tissue
    Uta Meyding-Lamade
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Neurosci Lett 318:21-4. 2002
    ..INOS inhibition may provide an additional therapeutic strategy targeted specifically to suppress iNOS expression as a potential secondary mechanism of tissue damage in acute and chronic HSVE...
  69. ncbi Incidence and pathogenesis of clinical relapse after herpes simplex encephalitis in adults
    B Sköldenberg
    Karolinska Institutet, Division of Infectious Diseases, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    J Neurol 253:163-70. 2006
    To study the occurrence of relapse of herpes simplex encephalitis (HSE) and to find out whether soluble activity markers in cerebrospinal fluid (CSF) indicate direct viral or immune- mediated events.
  70. pmc Evaluation of combination therapy using aciclovir and corticosteroid in adult patients with herpes simplex virus encephalitis
    S Kamei
    Division of Neurology, Department of Medicine, Nihon University School of Medicine, Itabashi ku, Tokyo 173 8610, Japan
    J Neurol Neurosurg Psychiatry 76:1544-9. 2005
    ..In the present investigation, the first to assess efficacy of corticosteroid treatment with aciclovir therapy in HSVE, multiple logistic regression analysis was performed of predictors of outcome in adult patients with HSVE...
  71. ncbi [Cerebral haematoma in the course of herpes simplex encephalitis]
    J M Politei
    Servicio de Neurologia, Hospital General de Agudos Juan A Fernández, Buenos Aires, Argentina
    Rev Neurol 36:636-9. 2003
    b>Herpes simplex encephalitis (HSE) is the most common cause of infectious encephalitis at all ages...
  72. ncbi Laboratory diagnosis of central nervous system infections caused by herpesviruses
    A Sauerbrei
    Institute for Antiviral Chemotherapy, Friedrich Schiller University Jena, Winzerlaer Stasse 10, D 07745 Jena, Germany
    J Clin Virol 25:S45-51. 2002
    Herpesviruses may be associated with various types of central nervous system (CNS) infections. Herpes simplex encephalitis (HSE) has to be considered one of the most severe diseases...
  73. ncbi Herpes simplex encephalitis presenting with exclusively frontal lobe involvement
    Sean W Taylor
    Department of Medicine Neurology, Queen s University, Kingston, Ontario, Canada
    J Neurovirol 13:477-81. 2007
    The authors report a patient with herpes simplex encephalitis who presented with magnetic resonance imaging (MRI) lesions exclusively in the frontal lobes, including the bilateral anterior cingulate gyri...
  74. ncbi Herpes simplex encephalitis
    Zhiping Hu
    Department of Neurology, Second Xiangya Hospital, China
    Lancet 362:280. 2003
  75. pmc Corticosteroids in herpes simplex virus encephalitis
    H Openshaw
    J Neurol Neurosurg Psychiatry 76:1469. 2005
  76. ncbi Late relapse of herpes simplex virus encephalitis in a child due to reactivation of latent virus: clinicopathological report and review
    Ronen Spiegel
    Pediatric Department A, Ha Emek Medical Center, Afula Israel
    J Child Neurol 23:344-8. 2008
    ..All cases of late relapse of herpes simplex virus encephalitis in the last 15 years are reviewed, with emphasis on clinical characteristics and possible mechanisms...
  77. ncbi [A case of brainstem encephalitis caused by herpes simplex virus type 1 with possible infection via trigeminal nerve]
    Yoshito Yoshidome
    Department of Neurology, Imakiire General Hospital
    Rinsho Shinkeigaku 45:293-7. 2005
    ..We herein presented a case of atypical encephalitis due to HSV-1 involving mainly the brainstem with possible infection via right trigeminal nerve and summarized recent 35 cases with herpetic brainstem encephalitis since 1990...
  78. pmc Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure-activity relationships and antiherpetic activity in vivo
    Andrzej Manikowski
    GLSynthesis Inc, One Innovation Drive, Worcester, Massachusetts 01605, USA
    J Med Chem 48:3919-29. 2005
    ..In assays lacking [3H]thymidine, HBPG was found to be an efficient substrate for the enzymes. The ability of the TKs to phosphorylate HBPG may relate to its antiherpetic activity in vivo...
  79. ncbi Recurrent herpes simplex virus hepatitis after liver retransplantation despite acyclovir therapy
    Thomas Longerich
    Institute of Pathology, Department of General Pathology, University of Heidelberg, Heidelberg, Germany
    Liver Transpl 11:1289-94. 2005
    ....
  80. ncbi [Herpes simplex encephalitis originating from bilateral thalamic lesions with hemorrhagic component]
    Jiro Sakaguchi
    Department of Strokology, Kumamoto City Hospital
    Rinsho Shinkeigaku 45:368-71. 2005
    ..The diagnosis of herpes simplex encephalitis was established by PCR of cerebrospinal fluid on the same day...
  81. ncbi Herpes simplex encephalitis
    Sean W Taylor
    Department of Medicine Neurology, Queen s University, Kingston, Ontario, Canada
    Can J Neurol Sci 32:246-7. 2005
  82. doi Temporal lobectomy in acute complicated herpes simplex encephalitis: technical case report
    Rocio Sanchez-Carpintero
    Department of Paediatrics, Paediatric Neurology Unit, University Clinic of Navarra, University of Navarra, Pamplona, Spain
    Neurosurgery 62:E1174-5; discussion E1175. 2008
    ..A surgical therapeutic approach may be needed because the infection can be resistant to acyclovir in immunocompromised patients, and complications and long-term sequelae are frequent...
  83. ncbi Diffusion-weighted magnetic resonance is better than polymerase chain reaction for early diagnosis of herpes simplex encephalitis: a case report
    Başak Nur Akyldz
    Departments of Pediatric Intensive Care, Medical Faculty, Erciyes University, Kayseri, Turkey
    Pediatr Emerg Care 24:377-9. 2008
    ..Therefore, diffusion-weighted magnetic resonance may play a major role as a first and early diagnostic step...
  84. ncbi Investigation of HSV-1, HSV-2, CMV, HHV-6 and HHV-8 DNA by real-time PCR in surgical resection materials of epilepsy patients with mesial temporal lobe sclerosis
    Hulya Karatas
    Hacettepe University, Faculty of Medicine, Department of Neurology, Sihhiye, Ankara, 06100, Turkey
    J Neurol Sci 264:151-6. 2008
    ..The objective of this study is to investigate the presence of viral DNAs of HSV-1, HSV-2, HHV-6, HHV-8, and CMV in hippocampus of the patients with mesial temporal lobe epilepsy (MTLE) syndrome...
  85. ncbi Acute retinal necrosis as a late sequela of herpes simplex type 1 encephalitis in a child
    Theodore H Curtis
    Department of Ophthalmology, University of Colorado, Rocky Mountain Lions Eye Institute, Aurora, CO 80045, USA
    J AAPOS 11:509-10. 2007
    ..Herein we report a child who developed acute retinal necrosis 17 months after HSV-1 encephalitis...
  86. ncbi HSV encephalitis in a child with brain stem glioma: a rare complication of therapy. Case report and review of the neurosurgical literature
    Barbara Spacca
    Department of Neurosurgery, Royal Liverpool Children s Hospital NHS Trust, Liverpool, UK
    Childs Nerv Syst 23:1347-50. 2007
    ..Herpes simplex virus (HSV) encephalitis is a rare association with pediatric neurosurgical pathologies...
  87. ncbi Herpes simplex virus type-1 meningoencephalitis showing disseminated cortical lesions
    Kosuke Naito
    Center for Neurological Diseases, Aizawa Hospital, Matsumoto
    Intern Med 46:761-3. 2007
    ..All of the cortical lesions were small and appeared to be located in the gray matter. The patient recovered with acyclovir. This report demonstrates that disseminated encephalitis can be a feature of acute HSV-1 infection...
  88. ncbi [Two cases of herpes encephalitis with normal cerebrospinal fluid findings]
    Vildan Avkan Oguz
    Dokuz Eylul Universitesi Tip Fakultesi, Enfeksiyon Hastaliklari ve Klinik Mikrobiyoloji Anabilim Dali, Izmir
    Mikrobiyol Bul 40:93-8. 2006
    ..In conclusion, even the CSF findings are normal, in cases considered to be HSV encephalitis, MRI should be the first radiological diagnostic step and the diagnosis should be confirmed by the detection of HSV DNA in CSF by PCR...
  89. ncbi Unusual presentation of herpes simplex virus encephalitis: bilateral thalamic involvement and normal imaging of early stage of the disease
    Hakan Gumus
    Department of Pediatric Neurology, Erciyes University Faculty of Medicine, 38039 Kayseri, Turkey
    Am J Emerg Med 25:87-9. 2007
  90. ncbi 73-year-old woman with fever and mental status changes
    Andrea N Leep Hunderfund
    Mayo School of Graduate Medical Education, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 82:874-7. 2007
  91. ncbi Steroids for deteriorating herpes simplex virus encephalitis
    Banan Musallam
    Department of Pediatrics, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel
    Pediatr Neurol 37:229-32. 2007
    ..This case suggests considering a short course of high-dose steroid therapy in severe herpes simplex encephalitis when there is clinical and radiologic deterioration in spite of appropriate antiviral therapy and ..
  92. ncbi [Therapy for herpes simplex virus encephalitis]
    Satoshi Kamei
    Division of Neurology, Department of Medicine, Nihon University School of Medicine
    Nihon Rinsho 64:296-301. 2006
  93. ncbi [Herpes encephalitis]
    Hiroshi Shoji
    First Department Neurology of Internal Medicine, Kurume University School of Medicine
    Nihon Rinsho 64:264-7. 2006
  94. ncbi [Diagnosis of HSV-1, HSV-2 infection]
    Yoshihiro Ando
    Infectious Disease and Immunology, Aichi Children s Health and Medical Center
    Nihon Rinsho 64:226-9. 2006
  95. ncbi [A herpes simplex virus encephalitis case with no clinical response to acyclovir treatment]
    Fatma Cakmak Celik
    Ondokuz Mayis Universitesi Tip Fakultesi, Cocuk Sagligi ve Hastaliklari Anabilim Dali, Samsun
    Mikrobiyol Bul 41:613-9. 2007
    ....
  96. pmc Herpes encephalitis presenting as mild aphasia: case report
    Omar A Khan
    Department of Family Medicine, University of Vermont, Burlington, Vermont 05405, USA
    BMC Fam Pract 7:22. 2006
    ..However, early detection via a low threshold of suspicion can be useful, leading in turn to early treatment and improved survival...
  97. ncbi Herpes encephalitis after meningioma resection
    Markus Ploner
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Neurology 65:1674-5. 2005
  98. ncbi [99mTc-HMPAO brain SPECT in a case of HSV encephalitis]
    L Campos Villarino
    Servicios de Medicina Nuclear, Hospital Meixoeiro, 36200 Vigo
    Rev Esp Med Nucl 24:199-203. 2005
    ..Furthermore, after clinical discharge, persistent metabolic abnormality was demonstrated in temporal cortex, responsible for concomitant mixed aphasia...
  99. ncbi Benign form of herpes simplex encephalitis
    Verajit Chotmongkol
    Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Southeast Asian J Trop Med Public Health 34:393-4. 2003
    ..Lumbar puncture showed high opening pressure with normal CSF profiles. The patient was treated with intravenous acyclovir which gave a favorable outcome...
  100. ncbi [Ischemic stroke and herpes simplex virus type-1 associated meningoencephalitis]
    N M Alexandri
    Service de Neurologie, Hôpital Général Evangelismos, Athenes, Grece
    Rev Neurol (Paris) 160:579-81. 2004
    ..We present the case of a young patient who suffered a stroke during a meningoencephalitis due to herpes simplex 1 and we review the relevant literature for a possible relation between the two entities...
  101. ncbi [Herpes simplex encephalitis with a normal cerebrospinal fluid]
    Erika Santos
    Med Clin (Barc) 122:357-8. 2004

Research Grants71

  1. Fate of neural stem cells during viral encephalitis
    MAXIM CHACKO JOSEPH CHEERAN; Fiscal Year: 2010
    ..This proposal investigates the properties of neural stem cells in herpes- infected animals, which will provide insights to develop novel therapies for neurological disorders seen in the wake of viral encephalitis. ..
  2. Cellular genes and signaling pathways as therapeutic targets for virus-induced CN
    Kenneth L Tyler; Fiscal Year: 2011
    ..g. acyclovir for herpes simplex encephalitis) disability and death remain significant...
  3. Mendelian genetic predisposition to herpes simplex encephalitis in childhood
    Jean Laurent Casanova; Fiscal Year: 2010
    Childhood herpes simplex encephalitis (HSE) is a life-threatening complication of primary infection by herpes simplex virus 1 (HSV-1), a common virus that is innocuous in most children...
  4. Cellular dissection of herpes simplex encephalitis with iPS cells
    Jean Laurent Casanova; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Herpes simplex encephalitis (HSE) of childhood is a life-threatening central nervous system (CNS)-specific complication of primary infection by herpes simplex virus 1 (HSV-1)...
  5. Immunoregulation of Herpes Encephalitis By Microglia
    James R Lokensgard; Fiscal Year: 2010
    ..In these experiments, we hope to identify new approaches to the treatment of herpes encephalitis and neuroAIDS, as well as other forms of viral encephalitis, which reduce the extent of immune- mediated mechanisms of brain damage. ..
  6. Immunoregulation of Herpes Encephalitis By Microglia
    JAMES LOKENSGARD; Fiscal Year: 2009
    ..In these experiments, we hope to identify new approaches to the treatment of herpes encephalitis and neuroAIDS, as well as other forms of viral encephalitis, which reduce the extent of immune- mediated mechanisms of brain damage. ..
  7. DRUGS TO PREVENT RECURRENT HERPESVIRUS INFECTIONS
    George Wright; Fiscal Year: 2001
    ..Virus shedding during subclinical recurrences may infect sex partners or newborns. Herpes simplex encephalitis is a continuing source of morbidity and neurological sequelae in newborns and adults...
  8. DRUGS TO PREVENT RECURRENT HERPESVIRUS INFECTIONS
    George Wright; Fiscal Year: 2000
    ..Virus shedding during subclinical recurrences may infect sex partners or newborns. Herpes simplex encephalitis is a continuing source of morbidity and neurological sequelae in newborns and adults...
  9. Genetic analysis of Herpes virus neurotropism and encephalitis
    JENNIFER HART LAVAIL; Fiscal Year: 2010
    ....
  10. Genetic analysis of Herpes virus neurotropism and encephalitis
    Jennifer LaVail; Fiscal Year: 2009
    ....
  11. Genetic analysis of Herpes virus neurotropism and encephalitis
    Jennifer LaVail; Fiscal Year: 2009
    ....
  12. Genetic analysis of Herpes virus neurotropism and encephalitis
    JENNIFER HART LAVAIL; Fiscal Year: 2010
    ....
  13. Mechanisms of Apoptosis in Virus-Infected Neurons
    JOHN DAVID BECKHAM; Fiscal Year: 2010
    ..While acyclovir therapy is effective for herpes simplex encephalitis, morbidity and mortality are still prominent in infected patient and additional strategies to treat ..
  14. Mechanisms of Apoptosis in Virus-Infected Neurons
    JOHN DAVID BECKHAM; Fiscal Year: 2010
    ..While acyclovir therapy is effective for herpes simplex encephalitis, morbidity and mortality are still prominent in infected patient and additional strategies to treat ..
  15. Mechanisms of Apoptosis in Virus-Infected Neurons
    J Beckham; Fiscal Year: 2009
    ..While acyclovir therapy is effective for herpes simplex encephalitis, morbidity and mortality are still prominent in infected patient and additional strategies to treat ..
  16. Mechanisms of Apoptosis in Virus-Infected Neurons
    J Beckham; Fiscal Year: 2009
    ..While acyclovir therapy is effective for herpes simplex encephalitis, morbidity and mortality are still prominent in infected patient and additional strategies to treat ..
  17. EARLY EVENTS IN HERPES SIMPLEX VIRUS ENTRY
    Roselyn Eisenberg; Fiscal Year: 2005
    ..These studies will provide a better understanding of HSV entry and enable the design of strategies for combating HSV infection and pathogenesis by targeting elements of the entry machinery. ..
  18. EARLY EVENTS IN HERPES SIMPLEX VIRUS ENTRY
    Roselyn Eisenberg; Fiscal Year: 2004
    ..These studies will provide a better understanding of HSV entry and enable the design of strategies for combating HSV infection and pathogenesis by targeting elements of the entry machinery. ..
  19. EARLY EVENTS IN HERPES SIMPLEX VIRUS ENTRY
    Roselyn Eisenberg; Fiscal Year: 2006
    ..These studies will provide a better understanding of HSV entry and enable the design of strategies for combating HSV infection and pathogenesis by targeting elements of the entry machinery. ..
  20. EARLY EVENTS IN HERPES SIMPLEX VIRUS ENTRY
    Roselyn Eisenberg; Fiscal Year: 2003
    ..These studies will provide a better understanding of HSV entry and enable the design of strategies for combating HSV infection and pathogenesis by targeting elements of the entry machinery. ..
  21. EARLY EVENTS IN HERPES SIMPLEX VIRUS ENTRY
    Roselyn Eisenberg; Fiscal Year: 2002
    ..These studies will provide a better understanding of HSV entry and enable the design of strategies for combating HSV infection and pathogenesis by targeting elements of the entry machinery. ..
  22. MECHANISMS OF HSV-1 TRANSPORT IN CNS NEURONS
    JUDY GARNER; Fiscal Year: 2002
    ..Though relatively rare, HSV1 can also be the primary cause of the more serious herpes simplex encephalitis, as well as systemic disseminated infections...
  23. MECHANISMS OF HSV-1 TRANSPORT IN CNS NEURONS
    JUDY GARNER; Fiscal Year: 2001
    ..Though relatively rare, HSV1 can also be the primary cause of the more serious herpes simplex encephalitis, as well as systemic disseminated infections...
  24. MECHANISMS OF HSV-1 TRANSPORT IN CNS NEURONS
    JUDY GARNER; Fiscal Year: 2003
    ..Though relatively rare, HSV1 can also be the primary cause of the more serious herpes simplex encephalitis, as well as systemic disseminated infections...
  25. MECHANISMS OF HSV-1 TRANSPORT IN CNS NEURONS
    JUDY GARNER; Fiscal Year: 2000
    ..Though relatively rare, HSV1 can also be the primary cause of the more serious herpes simplex encephalitis, as well as systemic disseminated infections...
  26. OCULAR HERPES SIMPLEX VIRUS
    Herbert Kaufman; Fiscal Year: 2003
    ..abstract_text> ..
  27. OCULAR HERPES SIMPLEX VIRUS
    Herbert Kaufman; Fiscal Year: 2004
    ..abstract_text> ..
  28. OCULAR HERPES SIMPLEX VIRUS
    Herbert Kaufman; Fiscal Year: 2002
    ..abstract_text> ..
  29. OCULAR HERPES SIMPLEX VIRUS
    Herbert Kaufman; Fiscal Year: 2004
    ..abstract_text> ..
  30. OCULAR HERPES SIMPLEX VIRUS
    Herbert Kaufman; Fiscal Year: 2001
    ..abstract_text> ..
  31. CORE--SCIENTIFIC FACILITY
    EARL KERN; Fiscal Year: 1999
    ..For promising lead compounds, pharmacokinetics, oral bioavailability, and toxicity to the major organ systems will be performed in mice. ..
  32. International Herpes Vaccine Project
    David Knipe; Fiscal Year: 2006
    ..In addition, NINDS has a mission to "reduce the burden of neurological disease... borne by people all over the world," and a vaccine to prevent HSV-2 or HSV-1 infection or disease would be directed towards this goal. ..
  33. International Herpes Vaccine Project
    David Knipe; Fiscal Year: 2009
    ..In addition, NINDS has a mission to "reduce the burden of neurological disease... borne by people all over the world," and a vaccine to prevent HSV-2 or HSV-1 infection or disease would be directed towards this goal. ..
  34. International Herpes Vaccine Project
    David Knipe; Fiscal Year: 2005
    ..In addition, NINDS has a mission to "reduce the burden of neurological disease... borne by people all over the world," and a vaccine to prevent HSV-2 or HSV-1 infection or disease would be directed towards this goal. ..
  35. International Herpes Vaccine Project
    David Knipe; Fiscal Year: 2007
    ..In addition, NINDS has a mission to "reduce the burden of neurological disease... borne by people all over the world," and a vaccine to prevent HSV-2 or HSV-1 infection or disease would be directed towards this goal. ..
  36. HERPES SIMPLEX VIRUS ENTRY INTO CELLS OF NEURAL ORIGIN
    Roselyn Eisenberg; Fiscal Year: 2002
    ..To test this hypothesis, two specific aims are proposed: 1) to characterize the interaction between purified forms of gD and hPRR1; and 2) to examine the gD-receptor interaction in viruses, cells, and tissues of human neural origin. ..
  37. HERPES SIMPLEX VIRUS ENTRY INTO CELLS OF NEURAL ORIGIN
    Roselyn Eisenberg; Fiscal Year: 2001
    ..To test this hypothesis, two specific aims are proposed: 1) to characterize the interaction between purified forms of gD and hPRR1; and 2) to examine the gD-receptor interaction in viruses, cells, and tissues of human neural origin. ..
  38. HERPES SIMPLEX VIRUS ENTRY INTO CELLS OF NEURAL ORIGIN
    Roselyn Eisenberg; Fiscal Year: 1999
    ..To test this hypothesis, two specific aims are proposed: 1) to characterize the interaction between purified forms of gD and hPRR1; and 2) to examine the gD-receptor interaction in viruses, cells, and tissues of human neural origin. ..
  39. HERPES SIMPLEX VIRUS ENTRY INTO CELLS OF NEURAL ORIGIN
    Roselyn Eisenberg; Fiscal Year: 2000
    ..To test this hypothesis, two specific aims are proposed: 1) to characterize the interaction between purified forms of gD and hPRR1; and 2) to examine the gD-receptor interaction in viruses, cells, and tissues of human neural origin. ..
  40. NORMAL AND DISORDERED LANGUAGE PROCESSING
    MARK SEIDENBERG; Fiscal Year: 1999
    ..The RSDA would also allow the applicant to acquire additional skills in computational modeling and in neurobiology needed in order to develop the research in these directions ..
  41. Immunoregulation of Herpes Encephalitis By Microglia
    JAMES LOKENSGARD; Fiscal Year: 2005
    ....
  42. Immunoregulation of Herpes Encephalitis By Microglia
    JAMES LOKENSGARD; Fiscal Year: 2004
    ....
  43. Immunoregulation of Herpes Encephalitis By Microglia
    JAMES LOKENSGARD; Fiscal Year: 2005
    ....
  44. Immunoregulation of Herpes Encephalitis By Microglia
    JAMES LOKENSGARD; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  45. Immunoregulation of Herpes Encephalitis By Microglia
    JAMES LOKENSGARD; Fiscal Year: 2003
    ....
  46. Immunoregulation of Herpes Encephalitis By Microglia
    JAMES LOKENSGARD; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  47. NEURAL BASES OF SEMANTIC MEMORY
    SHARON THOMPSON SCHILL; Fiscal Year: 2000
    ..Impairments of semantic memory have also been observed in patients with herpes simplex encephalitis, posterior cerebral artery infarctions, hypoxic-ischemic injury, and tumor resection...
  48. AMNESICS' REPRESENTATION OF DIRECT MEMORIES
    William Hirst; Fiscal Year: 1992
    ....
  49. THERAPIES FOR SEVERE HERPES VIRUS INFECTION
    RICHARD WHITIEY; Fiscal Year: 1991
    ..A pilot study to determine the factors which influence the frequency of transmission of herpes simplex virus to the neonate at birth with continued...
  50. NEURAL BASES OF SEMANTIC MEMORY
    SHARON THOMPSON SCHILL; Fiscal Year: 2001
    ..Impairments of semantic memory have also been observed in patients with herpes simplex encephalitis, posterior cerebral artery infarctions, hypoxic-ischemic injury, and tumor resection...
  51. NEURAL BASES OF SEMANTIC MEMORY
    SHARON THOMPSON SCHILL; Fiscal Year: 2002
    ..Impairments of semantic memory have also been observed in patients with herpes simplex encephalitis, posterior cerebral artery infarctions, hypoxic-ischemic injury, and tumor resection...
  52. NEURAL BASES OF SEMANTIC MEMORY
    SHARON THOMPSON SCHILL; Fiscal Year: 2002
    ..Impairments of semantic memory have also been observed in patients with herpes simplex encephalitis, posterior cerebral artery infarctions, hypoxic-ischemic injury, and tumor resection...
  53. AMNESICS' REPRESENTATION OF DIRECT MEMORIES
    William Hirst; Fiscal Year: 1990
    ....
  54. NEURAL BASES OF SEMANTIC MEMORY
    SHARON THOMPSON SCHILL; Fiscal Year: 2003
    ..Impairments of semantic memory have also been observed in patients with herpes simplex encephalitis, posterior cerebral artery infarctions, hypoxic-ischemic injury, and tumor resection...
  55. PHARMACOLOGIC ENHANCEMENT OF VIRAL ONCOLYSIS
    Ennio Chiocca; Fiscal Year: 2000
    ..tumor cell oncolysis by MGH, 2) This strategy provides for effective treatment in animal models of herpes simplex encephalitis, and 3) Modifications in the function of viral genes responsible for host cell toxicity and production ..
  56. ANIMAL MODELS OF HUMAN VIRAL INFECTIONS
    Robert Sidwell; Fiscal Year: 1991
    ....
  57. ANIMAL MODELS FOR ANTIVIRAL EVALUATION
    EARL KERN; Fiscal Year: 1990
    ....