Genomes and Genes
herpes simplex encephalitis
Summary: An acute (or rarely chronic) inflammatory process of the brain caused by SIMPLEXVIRUS infections which may be fatal. The majority of infections are caused by human herpesvirus 1 (HERPESVIRUS 1, HUMAN) and less often by human herpesvirus 2 (HERPESVIRUS 2, HUMAN). Clinical manifestations include FEVER; HEADACHE; SEIZURES; HALLUCINATIONS; behavioral alterations; APHASIA; hemiparesis; and COMA. Pathologically, the condition is marked by a hemorrhagic necrosis involving the medial and inferior TEMPORAL LOBE and orbital regions of the FRONTAL LOBE. (From Adams et al., Principles of Neurology, 6th ed, pp751-4)
Publications201 found, 100 shown here
- Herpes simplex encephalitisP G E Kennedy
J Neurol Neurosurg Psychiatry 73:237-8. 2002
- Herpes simplex infections of the nervous systemJ Richard Baringer
Department of Neurology, University of Utah Health Sciences Center, 50 North Medical Drive, Salt Lake City, UT 84132, USA
Neurol Clin 26:657-74, viii. 2008..Physicians need to develop an increased awareness of the early signs and symptoms of the presentation of HSVE, and of the imperative for early treatment...
- Re-evaluating the diagnostic methods in herpes simplex encephalitisAmer Al-Shekhlee
The Neurological Institute, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 44145, USA
Herpes 13:17-9. 2006Several methods are used in clinical practice to investigate herpes simplex encephalitis (HSE), including electroencephalography (EEG) and polymerase chain reaction (PCR) of the viral genome in cerebrospinal fluid...
- TLR3 deficiency in patients with herpes simplex encephalitisShen Ying Zhang
Human Genetics of Infectious Diseases, Institut National de la Sante et de la Recherche Medicale INSERM, U550, Faculty Necker, Paris 75015, France
Science 317:1522-7. 2007..Human TLR3 appears to be redundant in host defense to most microbes but is vital for natural immunity to HSV-1 in the CNS, which suggests that neurotropic viruses have contributed to the evolutionary maintenance of TLR3...
- Herpes simplex encephalitis in Sweden, 1990-2001: incidence, morbidity, and mortalityAnders Hjalmarsson
Infectious Diseases Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
Clin Infect Dis 45:875-80. 2007b>Herpes simplex encephalitis (HSE) is a devastating disease.
- The spectrum of herpes simplex encephalitis in childrenXavier De Tiège
Department of Paediatric Neurology, ULB Hopital Erasme, Brussels, Belgium
Eur J Paediatr Neurol 12:72-81. 2008Clinical and basic science research carried out in recent years into herpes simplex encephalitis (HSE) have shown that the concept of a "classical" picture of HSE in children is now outdated and that our current knowledge of ..
- Screening for possible failure of herpes simplex virus PCR in cerebrospinal fluid for the diagnosis of herpes simplex encephalitisE Puchhammer-Stöckl
Institute of Virology, University of Vienna, Vienna, Austria
J Med Virol 64:531-6. 2001..reliability of herpes simplex virus (HSV) PCR testing in cerebrospinal fluid (CSF) for the detection of herpes simplex encephalitis. This was done by examining retrospectively the clinical follow-up of a large group of patients tested ..
- Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitisRebeca Pérez de Diego
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Inserm U980, Necker Medical School, Paris, France
Immunity 33:400-11. 2010..Thus, TLR3-mediated immunity against primary infection by HSV-1 in the central nervous system is critically dependent on TRAF3...
- Herpes simplex encephalitis: children and adolescentsRichard J Whitley
Department of Pediatrics, The University of Alabama at Birmingham, AL, USA
Semin Pediatr Infect Dis 16:17-23. 2005b>Herpes simplex encephalitis (HSE) remains one of the most devastating infections of the central nervous system despite available antiviral therapy. Children and adolescents account for approximately one third of all cases of HSE...
- Update on herpes simplex encephalitisKenneth L Tyler
Department of Neurology, University of Colorado Health Sciences Center, and the Neurology Service of the Denver Veterans Affairs Medical Center, Denver, CO, USA
Rev Neurol Dis 1:169-78. 2004b>Herpes simplex encephalitis is the most common identified cause of sporadic viral encephalitis in the United States...
- [Herpes simplex encephalitis in childhood]Hiroshi Kimura
Department of Virology, Nagoya University Graduate School of Medicine
Rinsho Shinkeigaku 46:958-60. 2006Central nervous system (CNS) infection by herpes simplex virus (HSV) in childhood consists of herpes simplex encephalitis and CNS infections in neonates...
- Infantile herpes simplex encephalitis: diagnostic features and differentiation from non-accidental injuryJ Kurtz
Department of Virology, John Radcliffe Hospital, Oxford OX3 9DU, UK
J Infect 46:12-6. 2003..After a baby, subsequently proven to have HSE, had initially been diagnosed as non-accidental injury (NAI), we reviewed the clinical features and radiology of infants with HSE recently diagnosed by our laboratory...
- Herpes simplex encephalitis: diagnostic problems and late relapseXavier De Tiège
Department of Paediatric Neurology, Hopital Cochin Saint Vincent de Paul, Paris, France
Dev Med Child Neurol 48:60-3. 2006..Delayed intrathecal synthesis of specific anti-HSV antibodies was found on day 26 and confirmed herpes simplex encephalitis (HSE) diagnosis...
- Outcome of herpes simplex encephalitis in childrenWen Bin Hsieh
Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan
J Microbiol Immunol Infect 40:34-8. 2007b>Herpes simplex encephalitis (HSE) can cause high mortality and morbidity in children. Since local data of HSE in children are rare, we performed a retrospective study to evaluate the prognostic factors and outcome of HSE in Taiwan.
- Herpes simplex virus type 1 (HSV-1)--induced retinitis following herpes simplex encephalitis: indications for brain-to-eye transmission of HSV-1J Maertzdorf
Department of Virology, Erasmus University, Rotterdam, The Netherlands
Ann Neurol 49:104-6. 2001b>Herpes simplex encephalitis is a severe neurological disease with high mortality and morbidity rates...
- Basal ganglia involvement in a child with herpes simplex encephalitisGobinda Mondal
Pediatric Intensive Care Unit, Department of Pediatrics, Medical College and Hospital, Kolkata, India
Indian J Pediatr 76:749-50. 2009b>Herpes simplex encephalitis (HSE) is a leading cause of sporadic, nonepidemic viral encephalitis in children and adults...
- Patients with suspected herpes simplex encephalitis: rethinking an initial negative polymerase chain reaction resultAna A Weil
Viral and Rickettsial Disease Laboratory, Division of Communicable Disease Control, California Department of Health Services, Richmond, CA, 94804, USA
Clin Infect Dis 34:1154-7. 2002A statewide encephalitis diagnostic project of the California State Department of Health Services found that herpes simplex virus 1 DNA may not be detectable by molecular methods early in the clinical course of herpes simplex encephalitis.
- Herpes simplex encephalitis: MRI findings in two cases confirmed by polymerase chain reaction assayJ W Lee
Department of Radiology, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea
Pediatr Radiol 31:619-23. 2001..We present MRI findings of two cases of herpes simplex encephalitis (HSE) confirmed by PCR analysis, focusing on the serial changes after acyclovir therapy: gyral swelling,..
- Clinical spectrum, pitfalls in diagnosis and therapeutic implications in herpes simplex encephalitisS Jha
Department of Neurology SGPGIMS, Lucknow
J Assoc Physicians India 52:24-6. 2004OBJECTIVES: High index of suspicion is mandatory for early diagnosis of Herpes Simplex Encephalitis (HSE), since acyclovir therapy can prevent its mortality and limit morbidity...
- Herpes simplex encephalitis in a domestic rabbit (Oryctolagus cuniculus)P Grest
Institute of Veterinary Pathology, , , 8057, Switzerland
J Comp Pathol 126:308-11. 2002..The agent was classified as HSV-1 by polymerase chain reaction analysis. This is only the second reported natural case of herpes simplex infection in a rabbit...
- Neurolisteriosis mimicking herpes simplex encephalitis in an immunocompromized patientJohn Protopsaltis
Second Department of Internal Medicine, Tzanio General Hospital, Piraeus, Greece
Scand J Infect Dis 38:825-8. 2006..Nevertheless, PCR in CSF for Listeria monocytogens was positive. This case implies that Listeria might be considered in patients with clinical and imaging suspicion of herpetic encephalitis...
- Postinfectious autoimmune-mediated encephalitis eight months after herpes simplex encephalitisA A B Joos
Department of Neurology, University of Freiburg, Freiburg, Germany
Eur Neurol 50:54-6. 2003
- Glycyrrhizin increases survival of mice with herpes simplex encephalitisT Sekizawa
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
Acta Virol 45:51-4. 2001..5-29.0% to 81.8-83.3%; mean values from 2 experiments) while it reduced HSV-1 replication in the brain to 45.6% of the control. These results demonstrate a stimulative effect of GR on the mouse defense system(s) against HSV-1 infection...
- The chemokine CCL5 is essential for leukocyte recruitment in a model of severe Herpes simplex encephalitisMárcia Carvalho Vilela
Departamento de Clinica Medica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Ann N Y Acad Sci 1153:256-63. 2009..However, blocking of CCR1 and CCR5 did not affect HSV-1 replication, suggesting that other immune mechanisms are involved in the process of infection control...
- Traffic of leukocytes in the central nervous system is associated with chemokine up-regulation in a severe model of herpes simplex encephalitis: an intravital microscopy studyMárcia Carvalho Vilela
Pós Graduação em Infectologia e Medicina Tropical, Faculdade de Medicina FM, Universidade Federal de Minas Gerais UFMG, Belo Horizonte, Brazil
Neurosci Lett 445:18-22. 2008..These results corroborate the role of chemokines in leukocyte recruitment following HSV-1 infection in the central nervous system...
- Diffusion-weighted MRI in herpes simplex encephalitis: a report of three casesW Kuker
Department of Neuroradiology, University Hospital Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
Neuroradiology 46:122-5. 2004..Thus, DW-MRI may be a valuable tool for early detection and diagnosis of HSVE whereas contrast-enhanced images are indispensable after the first week...
- Herpes simplex encephalitis: adolescents and adultsRichard J Whitley
Department of Pediatrics, Infectious Diseases, The University of Alabama at Birmingham, 1600 Seventh Avenue, CHB 303, Birmingham, AL 35233, United States
Antiviral Res 71:141-8. 2006b>Herpes simplex encephalitis (HSE) remains one of the most devastating infections of the central nervous system despite available antiviral therapy. Children and adolescents account for approximately one third of all cases of HSE...
- Herpes simplex encephalitis: some interesting presentationsS Jha
Department of Neurology, SGPGIMS, Lucknow, India
Neurol India 51:399-400. 2003b>Herpes Simplex Encephalitis (HSE) is the most common cause of fatal viral encephalitis. A high index of suspicion is mandatory for early diagnosis and successful therapy to restrict morbidity and mortality...
- Expression of Toll-like receptor 3 in the human cerebellar cortex in rabies, herpes simplex encephalitis, and other neurological diseasesAlan C Jackson
Unité de Neuroimmunologie Virale, Département de Neuroscience, Institut Pasteur, Paris, France
J Neurovirol 12:229-34. 2006..Purkinje cells were found to express TLR-3 in all cases of rabies (4 of 4) and herpes simplex encephalitis (2 of 2) as well as in cases of amyotrophic lateral sclerosis (1 of 2), stroke (1 of 2), and Alzheimer'..
- A 12-year prospective study of childhood herpes simplex encephalitis: is there a broader spectrum of disease?Jorina M Elbers
Division of Neurology, Hospital for Sick Children and University of Toronto, Toronto, Ontario, M5G 1X8, Canada
Pediatrics 119:e399-407. 2007The purpose of this study was to review the experience with herpes simplex encephalitis at the Hospital for Sick Children over the past 12 years.
- Relapsing herpes simplex encephalitis: pathological confirmation of viral reactivationS Yamada
Department of Neurology, Gifu Prefectural Tajimi Hospital, Gifu, Japan
J Neurol Neurosurg Psychiatry 74:262-4. 2003This case is reported to raise awareness of herpes simplex encephalitis as a persisting brain disorder...
- Diffusion-weighted imaging and apparent diffusion coefficient evaluation of herpes simplex encephalitis and Japanese encephalitisVijay Sawlani
Department of Radiology, Morriston Hospital, Swansea SA6 6NL, UK
J Neurol Sci 287:221-6. 2009..imaging (DWI) and apparent diffusion coefficient (ADC) values in differentiating necrotising herpes simplex encephalitis (HSE) and non-necrotising Japanese encephalitis (JE) and (b) to correlate the ADC values with the ..
- Antiviral therapy for herpesvirus central nervous system infections: neonatal herpes simplex virus infection, herpes simplex encephalitis, and congenital cytomegalovirus infectionScott H James
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233 1711, United States
Antiviral Res 83:207-13. 2009..Although advances in antiviral agents have led to improved outcomes, there is still a need for more effective treatments...
- Modulation of sFas indicates apoptosis in human herpes simplex encephalitisFarideh Sabri
Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
J Neuroimmunol 171:171-6. 2006b>Herpes simplex encephalitis (HSE) is the most common cause of non-epidemic, acute and fatal viral encephalitis. A pronounced mortality and morbidity remains in HSE despite antiviral treatment...
- Incidence and pathogenesis of clinical relapse after herpes simplex encephalitis in adultsB Sköldenberg
Karolinska Institutet, Division of Infectious Diseases, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
J Neurol 253:163-70. 2006To study the occurrence of relapse of herpes simplex encephalitis (HSE) and to find out whether soluble activity markers in cerebrospinal fluid (CSF) indicate direct viral or immune- mediated events.
- Acute and long-term alteration of chemokine mRNA expression after anti-viral and anti-inflammatory treatment in herpes simplex virus encephalitisJohann Sellner
Department of Neurology, Im Neuenheimer Feld 400, Ruprecht Karls University Heidelberg, D 69120 Heidelberg, Germany
Neurosci Lett 374:197-202. 2005..This pattern was substantially altered by anti-viral and anti-inflammatory treatment. Our findings indicate a pivotal role of these chemokines in the immunopathogenesis of HSVE...
- Prognostic value of intrathecal antibody production and DNA viral load in cerebrospinal fluid of patients with herpes simplex encephalitisAnders Hjalmarsson
Department of Medicine Solna, Infectious Diseases Unit, Karolinska Institutet, Stockholm 17176, Sweden
J Neurol 256:1243-51. 2009b>Herpes simplex encephalitis is a devastating disease...
- Extra temporal involvement in herpes simplex encephalitisM Wasay
Department of Medicine and Neurology, The Aga Khan University, Karachi, Pakistan
Eur J Neurol 12:475-9. 2005Temporal lobe abnormalities on brain imaging have been described as strong evidence for herpes simplex encephalitis (HSE) in appropriate clinical settings. Extra temporal abnormalities are less well described in these patients...
- Increased presence of matrix metalloproteinases 2 and 9 in short- and long-term experimental herpes simplex virus encephalitisFrancisco J Martinez-Torres
Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
Neurosci Lett 368:274-8. 2004..Increased presence of MMP2 and MMP9 in chronic HSVE may contribute to ongoing damage. Inhibition of MMP2 and MMP9 might be a suitable target for therapeutic intervention...
- Herpes simplex virus infections of the central nervous system: encephalitis and meningitis, including Mollaret'sKenneth L Tyler
Department of Neurology, University of Colorado Health Sciences Center and Denver Veterans Affairs Medical Center, Denver, Colorado 80262, USA
Herpes 11:57A-64A. 2004b>Herpes simplex encephalitis (HSE) is a life-threatening consequence of herpes simplex virus (HSV) infection of the central nervous system (CNS)...
- Herpes simplex encephalitis: a case reportMaciej Jabłkowski
Clinic for Infectious Diseases, Medical University of Łódź, Poland
Med Sci Monit 10:CS41-5. 2004Despite advances in antiviral therapy over the past 2 decades, herpes simplex encephalitis (HSE) remains a serious illness with significant risk of morbidity and death...
- Progression of MRI abnormalities in herpes simplex encephalitis despite clinical improvement: natural history or disease progression?P Gaviani
Neurological Clinic, Ospedale Maggiore della Carita, A Avogadro University of Eastern Piedmont, Corso Mazzini 18, I 28100 Novara, Italy
Neurol Sci 25:104-7. 2004..Imaging studies of a cohort of patients surviving PCR-confirmed HSVE are needed to determine whether this pattern is occasional or a frequent form of progression...
- Herpes simplex encephalitis: an audit of the use of laboratory diagnostic testsJ Chataway
Departments of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
QJM 97:325-30. 2004The combination of both PCR and intrathecal antibody studies is recommended to confirm or refute the diagnosis of herpes simplex encephalitis (HSE).
- Experimental herpes simplex virus encephalitis: inhibition of the expression of inducible nitric oxide synthase in mouse brain tissueUta Meyding-Lamade
Department of Neurology, University of Heidelberg, Heidelberg, Germany
Neurosci Lett 318:21-4. 2002..INOS inhibition may provide an additional therapeutic strategy targeted specifically to suppress iNOS expression as a potential secondary mechanism of tissue damage in acute and chronic HSVE...
- Diffusion-weighted imaging findings on MRI as the sole radiographic findings in a child with proven herpes simplex encephalitisMakram Obeid
Department of Pediatrics, Texas Tech University Health Sciences Center, 3601 4th St, Lubbock, TX 79430, USA
Pediatr Radiol 37:1159-62. 2007We present a case of herpes simplex encephalitis in an 8-year-old girl, in whom hyperintensity was detected on diffusion-weighted imaging (DWI) while conventional MRI sequences were normal 1 week after the onset of neurological symptoms...
- Herpes simplex replication and dissemination is not increased by corticosteroid treatment in a rat model of focal Herpes encephalitisK A Thompson
Infectious Diseases Unit, School of Medicine, Monash University, Victoria, Australia
J Neurovirol 6:25-32. 2000..Corticosteroids could have an important role in the management of Herpes simplex encephalitis because their anti-inflammatory action reduces cerebral oedema...
- Herpes simplex encephalitis: involvement of apolipoprotein E genotypeW R Lin
Molecular Neurobiology Laboratory, Department of Optometry and Neuroscience, UMIST, Manchester M60 1QD, UK
J Neurol Neurosurg Psychiatry 70:117-9. 2001..Whether a specific allele of the gene is involved in susceptibility to another disorder caused by HSV1-herpes simplex encephalitis (HSE)-has now been investigated...
- Neurosyphilis presenting as herpes simplex encephalitisI Szilak
Montefiore Medical Center, Bronx, NY 10461, USA
Clin Infect Dis 32:1108-9. 2001We report the case of a 55-year-old man with neurosyphilis that presented with features of herpes simplex encephalitis. Neurosyphilis is easily diagnosed and treated and should be included in the differential diagnosis of herpes simplex ..
- La Crosse encephalitis presenting like herpes simplex encephalitis in an immunocompromised adultR Wurtz
Department of Medicine, Evanston Hospital, Evanston, Illinois 60621, USA
Clin Infect Dis 31:1113-4. 2000..Because herpes simplex encephalitis (HSE) can be neurologically devastating and is treatable, timely diagnosis is important...
- Virological diagnosis of herpes simplex encephalitisA Sauerbrei
Institute for Antiviral Chemotherapy, Friedrich Schiller University Jena, Nordhäuser Strasse 78, D 99089, Erfurt, Germany
J Clin Virol 17:31-6. 2000The herpes simplex encephalitis (HSE) represents one of the most severe infectious diseases of the central nervous system. As effective antiviral drugs are available, rapid and reliable diagnosis has become important.
- In vivo visualization of activated glia by [11C] (R)-PK11195-PET following herpes encephalitis reveals projected neuronal damage beyond the primary focal lesionA Cagnin
MRC Cyclotron Unit, Imperial College, Faculty of Medicine, Hammersmith Hospital, UK
Brain 124:2014-27. 2001..Two patients with asymmetrical herpes simplex encephalitis were serially scanned 6 and 12 months after the acute illness using PET with [11C] (R)-PK11195, a ..
- Outcome of and prognostic factors for herpes simplex encephalitis in adult patients: results of a multicenter studyFranck Raschilas
Laboratoire de Virologie, , , , Paris, France
Clin Infect Dis 35:254-60. 2002Management of herpes simplex encephalitis (HSE) has been considerably improved by the availability of acyclovir therapy and rapid polymerase chain reaction (PCR)-based diagnostic assays...
- Herpes simplex encephalitis in North West IndiaA Panagariya
Department of Neurology, SMS Medical College and Hospital, Jaipur 302004, India
Neurol India 49:360-5. 2001..diagnosis of cerebral venous thrombosis, cerebral malaria, tubercular meningitis etc, who resembled herpes simplex encephalitis (HSE), were excluded systematically with relevant investigations...
- Quantitation of intrathecal antibodies in cerebrospinal fluid of subacute sclerosing panencephalitis, herpes simplex encephalitis and multiple sclerosis: discrimination between microorganism-driven and polyspecific immune responseC Jacobi
Neurochemistry Laboratory, University of Gottingen, Robert Koch Str 40, D 37075 Gottingen, Germany
J Neuroimmunol 187:139-46. 2007..for HSV or measles has about 20- to 60-fold higher values in virus-caused antibody synthesis in acute herpes simplex encephalitis (mean HSV-F(S)=8.9%) or subacute sclerosing panencephalitis (mean measles-F(S)=18...
- Differential diagnosis of mesiotemporal lesions: case report of neurosyphilisA Vieira Santos
Neuroradiology Department, Garcia de Orta Hospital, Almada, Portugal
Neuroradiology 47:664-7. 2005We report a clinical and imaging case of suspected herpes simplex encephalitis subsequently diagnosed as neurosyphilis based on positive antibodies in the CSF...
- Burden of encephalitis-associated hospitalizations in the United States, 1988-1997Nino Khetsuriani
Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Clin Infect Dis 35:175-82. 2002..The average cost of an encephalitis-associated hospitalization, as determined by the Healthcare Cost and Utilization Project for 1997, was $28,151, for an annual national cost of hospitalization of $650 million...
- Evaluation of combination therapy using aciclovir and corticosteroid in adult patients with herpes simplex virus encephalitisS Kamei
Division of Neurology, Department of Medicine, Nihon University School of Medicine, Itabashi ku, Tokyo 173 8610, Japan
J Neurol Neurosurg Psychiatry 76:1544-9. 2005..In the present investigation, the first to assess efficacy of corticosteroid treatment with aciclovir therapy in HSVE, multiple logistic regression analysis was performed of predictors of outcome in adult patients with HSVE...
- Herpes simplex encephalitisZhiping Hu
Department of Neurology, Second Xiangya Hospital, China
Lancet 362:280. 2003
- Laboratory diagnosis of central nervous system infections caused by herpesvirusesA Sauerbrei
Institute for Antiviral Chemotherapy, Friedrich Schiller University Jena, Winzerlaer Stasse 10, D 07745 Jena, Germany
J Clin Virol 25:S45-51. 2002Herpesviruses may be associated with various types of central nervous system (CNS) infections. Herpes simplex encephalitis (HSE) has to be considered one of the most severe diseases...
- Atypical case of Herpes simplex encephalitisP Auyeung
Intern Med J 38:294-5. 2008
- Asymptomatic self-limiting white matter lesions in the chronic phase of herpes simplex encephalitisNobuto Mitsufuji
Department of Pediatrics, Kyoto First Red Cross Hospital, 15 749, Honmachi, Higashiyama ku, Kyoto, Japan
Brain Dev 24:300-3. 2002We report a 9-month-old girl with herpes simplex encephalitis. T(2)-weighted magnetic resonance imaging (MRI) on the 8th day of illness showed increased signal intensity in the gray and white matter of the bilateral lobes, especially the ..
- Diffuse white matter lesions in a case of herpes simplex encephalitisNaohisa Ueda
J Neurol 250:867-8. 2003
- Herpes simplex encephalitis presenting with exclusively frontal lobe involvementSean W Taylor
Department of Medicine Neurology, Queen s University, Kingston, Ontario, Canada
J Neurovirol 13:477-81. 2007The authors report a patient with herpes simplex encephalitis who presented with magnetic resonance imaging (MRI) lesions exclusively in the frontal lobes, including the bilateral anterior cingulate gyri...
- Postinfectious immune-mediated encephalitis after pediatric herpes simplex encephalitisXavier De Tiège
Department of Pediatric Neurology, ULB Hôpital Erasme Brussels, Brussels, Belgium
Brain Dev 27:304-7. 2005..deterioration clinically characterized by a partial Kluver-Bucy syndrome, 1 month after the onset of herpes simplex encephalitis. This episode is unlikely due to continuation or resumption of cerebral viral replication but might be ..
- [Cerebral haematoma in the course of herpes simplex encephalitis]J M Politei
Servicio de Neurologia, Hospital General de Agudos Juan A Fernández, Buenos Aires, Argentina
Rev Neurol 36:636-9. 2003b>Herpes simplex encephalitis (HSE) is the most common cause of infectious encephalitis at all ages...
- [Herpes simplex encephalitis originating from bilateral thalamic lesions with hemorrhagic component]Jiro Sakaguchi
Department of Strokology, Kumamoto City Hospital
Rinsho Shinkeigaku 45:368-71. 2005..The diagnosis of herpes simplex encephalitis was established by PCR of cerebrospinal fluid on the same day...
- Investigation of HSV-1, HSV-2, CMV, HHV-6 and HHV-8 DNA by real-time PCR in surgical resection materials of epilepsy patients with mesial temporal lobe sclerosisHulya Karatas
Hacettepe University, Faculty of Medicine, Department of Neurology, Sihhiye, Ankara, 06100, Turkey
J Neurol Sci 264:151-6. 2008..The objective of this study is to investigate the presence of viral DNAs of HSV-1, HSV-2, HHV-6, HHV-8, and CMV in hippocampus of the patients with mesial temporal lobe epilepsy (MTLE) syndrome...
- [Herpetic encephalitis: case series of 15 patients confirmed by polymerase chain reaction]Alberto Fica
Sección Infectología, Hospital Clinico Universidad de Chile, Santiago, Chile
Rev Chilena Infectol 22:38-46. 2005..Six patients (40%) showed neurological deficit at discharge. Death or neurological deficit at discharge was associated with a delay > 3 days before acyclovir therapy. (p = 0.01, two-tailed Fisher test)...
- Recurrent herpes simplex virus hepatitis after liver retransplantation despite acyclovir therapyThomas Longerich
Institute of Pathology, Department of General Pathology, University of Heidelberg, Heidelberg, Germany
Liver Transpl 11:1289-94. 2005....
- [99mTc-HMPAO brain SPECT in a case of HSV encephalitis]L Campos Villarino
Servicios de Medicina Nuclear, Hospital Meixoeiro, 36200 Vigo
Rev Esp Med Nucl 24:199-203. 2005..Furthermore, after clinical discharge, persistent metabolic abnormality was demonstrated in temporal cortex, responsible for concomitant mixed aphasia...
- Late relapse of herpes simplex virus encephalitis in a child due to reactivation of latent virus: clinicopathological report and reviewRonen Spiegel
Pediatric Department A, Ha Emek Medical Center, Afula Israel
J Child Neurol 23:344-8. 2008..All cases of late relapse of herpes simplex virus encephalitis in the last 15 years are reviewed, with emphasis on clinical characteristics and possible mechanisms...
- [A case of brainstem encephalitis caused by herpes simplex virus type 1 with possible infection via trigeminal nerve]Yoshito Yoshidome
Department of Neurology, Imakiire General Hospital
Rinsho Shinkeigaku 45:293-7. 2005..We herein presented a case of atypical encephalitis due to HSV-1 involving mainly the brainstem with possible infection via right trigeminal nerve and summarized recent 35 cases with herpetic brainstem encephalitis since 1990...
- Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure-activity relationships and antiherpetic activity in vivoAndrzej Manikowski
GLSynthesis Inc, One Innovation Drive, Worcester, Massachusetts 01605, USA
J Med Chem 48:3919-29. 2005..In assays lacking [3H]thymidine, HBPG was found to be an efficient substrate for the enzymes. The ability of the TKs to phosphorylate HBPG may relate to its antiherpetic activity in vivo...
- Herpes simplex encephalitisSean W Taylor
Department of Medicine (Neurology, Queen's University, Kingston, Ontario, Canada
Can J Neurol Sci 32:246-7. 2005
- Steroids for deteriorating herpes simplex virus encephalitisBanan Musallam
Department of Pediatrics, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel
Pediatr Neurol 37:229-32. 2007..This case suggests considering a short course of high-dose steroid therapy in severe herpes simplex encephalitis when there is clinical and radiologic deterioration in spite of appropriate antiviral therapy and ..
- [A herpes simplex virus encephalitis case with no clinical response to acyclovir treatment]Fatma Cakmak Celik
Ondokuz Mayis Universitesi Tip Fakultesi, Cocuk Sagligi ve Hastaliklari Anabilim Dali, Samsun
Mikrobiyol Bul 41:613-9. 2007....
- Appropriate use of polymerase chain reaction for detection of herpes simplex virus 2 in cerebrospinal fluid of patients at an inner-city hospitalNelia Afonso
Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, MI 48201, USA
Diagn Microbiol Infect Dis 57:309-13. 2007..PCR testing for HSV-2 in CSF at inner-city hospitals can be greatly reduced by the application of these parameters...
- Unusual presentation of herpes simplex virus encephalitis: bilateral thalamic involvement and normal imaging of early stage of the diseaseHakan Gumus
Department of Pediatric Neurology, Erciyes University Faculty of Medicine, 38039 Kayseri, Turkey
Am J Emerg Med 25:87-9. 2007
- Diffusion-weighted magnetic resonance is better than polymerase chain reaction for early diagnosis of herpes simplex encephalitis: a case reportBaşak Nur Akyldz
Departments of Pediatric Intensive Care, Medical Faculty, Erciyes University, Kayseri, Turkey
Pediatr Emerg Care 24:377-9. 2008..Therefore, diffusion-weighted magnetic resonance may play a major role as a first and early diagnostic step...
- [Two cases of herpes encephalitis with normal cerebrospinal fluid findings]Vildan Avkan Oguz
Dokuz Eylul Universitesi Tip Fakultesi, Enfeksiyon Hastaliklari ve Klinik Mikrobiyoloji Anabilim Dali, Izmir
Mikrobiyol Bul 40:93-8. 2006..In conclusion, even the CSF findings are normal, in cases considered to be HSV encephalitis, MRI should be the first radiological diagnostic step and the diagnosis should be confirmed by the detection of HSV DNA in CSF by PCR...
- Temporal lobectomy in acute complicated herpes simplex encephalitis: technical case reportRocio Sanchez-Carpintero
Department of Paediatrics, Paediatric Neurology Unit, University Clinic of Navarra, University of Navarra, Pamplona, Spain
Neurosurgery 62:E1174-5; discussion E1175. 2008..A surgical therapeutic approach may be needed because the infection can be resistant to acyclovir in immunocompromised patients, and complications and long-term sequelae are frequent...
- Herpes simplex virus type-1 meningoencephalitis showing disseminated cortical lesionsKosuke Naito
Center for Neurological Diseases, Aizawa Hospital, Matsumoto
Intern Med 46:761-3. 2007..All of the cortical lesions were small and appeared to be located in the gray matter. The patient recovered with acyclovir. This report demonstrates that disseminated encephalitis can be a feature of acute HSV-1 infection...
- [Therapy for herpes simplex virus encephalitis]Satoshi Kamei
Division of Neurology, Department of Medicine, Nihon University School of Medicine
Nippon Rinsho 64:296-301. 2006
- [Herpes encephalitis]Hiroshi Shoji
First Department (Neurology) of Internal Medicine, Kurume University School of Medicine
Nippon Rinsho 64:264-7. 2006
- [Diagnosis of HSV-1, HSV-2 infection]Yoshihiro Ando
Infectious Disease and Immunology, Aichi Children's Health and Medical Center
Nippon Rinsho 64:226-9. 2006
- Herpes encephalitis presenting as mild aphasia: case reportOmar A Khan
Department of Family Medicine, University of Vermont, Burlington, Vermont 05405, USA
BMC Fam Pract 7:22. 2006..However, early detection via a low threshold of suspicion can be useful, leading in turn to early treatment and improved survival...
- HSV encephalitis in a child with brain stem glioma: a rare complication of therapy. Case report and review of the neurosurgical literatureBarbara Spacca
Department of Neurosurgery, Royal Liverpool Children s Hospital NHS Trust, Liverpool, UK
Childs Nerv Syst 23:1347-50. 2007..Herpes simplex virus (HSV) encephalitis is a rare association with pediatric neurosurgical pathologies...
- 73-year-old woman with fever and mental status changesAndrea N Leep Hunderfund
Mayo School of Graduate Medical Education, Mayo Clinic, Rochester, MN 55905, USA
Mayo Clin Proc 82:874-7. 2007
- Herpes encephalitis after meningioma resectionMarkus Ploner
Department of Neurology, Heinrich Heine University, , Germany
Neurology 65:1674-5. 2005
- Corticosteroids in herpes simplex virus encephalitisH Openshaw
J Neurol Neurosurg Psychiatry 76:1469. 2005
- Acute retinal necrosis as a late sequela of herpes simplex type 1 encephalitis in a childTheodore H Curtis
Department of Ophthalmology, University of Colorado, Rocky Mountain Lions Eye Institute, Aurora, CO 80045, USA
J AAPOS 11:509-10. 2007..Herein we report a child who developed acute retinal necrosis 17 months after HSV-1 encephalitis...
- Brain stem encephalitis caused by primary herpes simplex 2 infection in a young womanJ W Tang
Department of Virology, Royal Free and University College Medical School, Cleveland Street, London W1, UK
J Neurol Neurosurg Psychiatry 74:1323-5. 2003....
- [Value of the polymerase chain reaction in the diagnosis of herpes infections of the nervous system]Diana García-Bardeci
Servicio de Microbiologia, Hospital de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Spain
Enferm Infecc Microbiol Clin 22:150-5. 2004....
- Differences in pathogenicity of herpes simplex virus serotypes 1 and 2 may be observed by histopathology and high-resolution magnetic resonance imaging in a murine encephalitis modelH C Thomas
Department of Safety Assessment, SmithKline Beecham Pharmaceuticals, Collegeville, Pennsylvania 19426, USA
J Neurovirol 7:105-16. 2001....
- [Herpes simplex virus type 1 acute retinal necrosis two years after presumably herpetic meningoencephalitis]E Díaz de Durana Santa Coloma
Hospital de Galdacano, Servicio Vasco de Salud Osakidetza, Vizcaya, Espana
Arch Soc Esp Oftalmol 79:33-5. 2004..PCR of the vitreous was positive for herpes simplex virus type I. DISCUSSION: This is probably a case of brain-to-eye virus transmission. According to this, the ARN would support the etiologic suspicion of the previous encephalitis...
- 6-azacytidine--compound with wide spectrum of antiviral activityI Alexeeva
Institute of Molecular Biology and Genetics, Kyiv, Ukraine
Nucleosides Nucleotides Nucleic Acids 20:1147-52. 2001..It inhibit synthesis of viral DNA and proteins. 6-AC shows antiherpetic and antiinfluenza action during experimental infection in mice. 6-AC is prospective for drug development as an antiviral substance with a wide spectrum of activity...
- Late recurrence of herpes simplex virus meningoencephalitis in two infantsH Mandyla
First Department of Paediatrics, Athens University, Aghia Sophia Children's Hospital, Greece
Eur J Pediatr 160:732-5. 2001....
- [Rapid diagnosis of herpetic meningoencephalitis by PCR]Carmen Muñoz-Almagro
Servicios de Microbiologia, Hospital Sant Joan de Deu, Esplugues de Llobregat, Barcelona, Espana
Enferm Infecc Microbiol Clin 20:110-2. 2002..To evaluate the usefulness of a rapid and simple PCR method in the diagnosis of herpetic meningoencephalitis in a pediatric population...
- [Herpetic encephalitis in childhood: a diagnosis which should not be forgotten]J P Oliveira Monteiro
Servicio de Pediatria, Hospital Garcia de Orta, Almada, 2800 525, Portugal
Rev Neurol 34:343-8. 2002b>Herpes simplex encephalitis is a serious infection of the nervous system, causing death or considerable neurological morbidity in infants and children. Rapid diagnosis and prompt institution of antiviral therapy is essential...
- Benign form of herpes simplex encephalitisVerajit Chotmongkol
Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
Southeast Asian J Trop Med Public Health 34:393-4. 2003..Lumbar puncture showed high opening pressure with normal CSF profiles. The patient was treated with intravenous acyclovir which gave a favorable outcome...
- Herpes simplex virus type 1 encephalitis associated with acute retinal necrosis syndrome in an immunocompetent patientPhilippe Gain
Department of Ophthalmology, Bellevue Hospital, Saint Etienne, France
Acta Ophthalmol Scand 80:546-9. 2002The onset of acute retinal necrosis secondary to herpes simplex encephalitis is exceptional...
- Fate of neural stem cells during viral encephalitisMAXIM CHACKO JOSEPH CHEERAN; Fiscal Year: 2010..This proposal investigates the properties of neural stem cells in herpes- infected animals, which will provide insights to develop novel therapies for neurological disorders seen in the wake of viral encephalitis. ..
- Mendelian genetic predisposition to herpes simplex encephalitis in childhoodJean Laurent Casanova; Fiscal Year: 2010Childhood herpes simplex encephalitis (HSE) is a life-threatening complication of primary infection by herpes simplex virus 1 (HSV-1), a common virus that is innocuous in most children...
- Cellular dissection of herpes simplex encephalitis with iPS cellsJean Laurent Casanova; Fiscal Year: 2010b>Herpes simplex encephalitis (HSE) of childhood is a life-threatening central nervous system (CNS)-specific complication of primary infection by herpes simplex virus 1 (HSV-1)...
- Immunoregulation of Herpes Encephalitis By MicrogliaJames R Lokensgard; Fiscal Year: 2010..In these experiments, we hope to identify new approaches to the treatment of herpes encephalitis and neuroAIDS, as well as other forms of viral encephalitis, which reduce the extent of immune- mediated mechanisms of brain damage. ..
- Genetic analysis of Herpes virus neurotropism and encephalitisJENNIFER HART LAVAIL; Fiscal Year: 2010....
- Genetic analysis of Herpes virus neurotropism and encephalitisJENNIFER HART LAVAIL; Fiscal Year: 2010....
- EARLY EVENTS IN HERPES SIMPLEX VIRUS ENTRYRoselyn Eisenberg; Fiscal Year: 2006..These studies will provide a better understanding of HSV entry and enable the design of strategies for combating HSV infection and pathogenesis by targeting elements of the entry machinery. ..
- MECHANISMS OF HSV-1 TRANSPORT IN CNS NEURONSJUDY GARNER; Fiscal Year: 2003..Though relatively rare, HSV1 can also be the primary cause of the more serious herpes simplex encephalitis, as well as systemic disseminated infections...
- OCULAR HERPES SIMPLEX VIRUSHerbert Kaufman; Fiscal Year: 2004..abstract_text> ..
- International Herpes Vaccine ProjectDavid Knipe; Fiscal Year: 2009..In addition, NINDS has a mission to "reduce the burden of neurological disease... borne by people all over the world," and a vaccine to prevent HSV-2 or HSV-1 infection or disease would be directed towards this goal. ..
- Immunoregulation of Herpes Encephalitis By MicrogliaJAMES LOKENSGARD; Fiscal Year: 2007....
- NEURAL BASES OF SEMANTIC MEMORYSHARON THOMPSON SCHILL; Fiscal Year: 2003..Impairments of semantic memory have also been observed in patients with herpes simplex encephalitis, posterior cerebral artery infarctions, hypoxic-ischemic injury, and tumor resection...