ebola hemorrhagic fever

Summary

Summary: A highly fatal, acute hemorrhagic fever, clinically very similar to MARBURG VIRUS DISEASE, caused by EBOLA-LIKE VIRUSES, first occurring in the Sudan and adjacent northwestern (what was then) Zaire. The natural reservoir and mode of transmission of the virus are unknown, but secondary infection is by direct contact with infected blood and other body secretions. (From Dorland, 28th ed)

Top Publications

  1. ncbi Fruit bats as reservoirs of Ebola virus
    Eric M Leroy
    Centre International de Recherches Medicales de Franceville, BP 769 Franceville, Gabon
    Nature 438:575-6. 2005
  2. ncbi Ebola outbreak killed 5000 gorillas
    Magdalena Bermejo
    Ecosystèmes Forestiers d Afrique Centrale ECOFAC, Box Postale 15115 Libreville, Gabon
    Science 314:1564. 2006
  3. ncbi Ebola virus: new insights into disease aetiopathology and possible therapeutic interventions
    Thomas W Geisbert
    Department of Viral Pathology and Ultrastructure, Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Expert Rev Mol Med 6:1-24. 2004
  4. ncbi Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients
    S Baize
    Centre International de Recherches Medicales de Franceville, Gabon
    Nat Med 5:423-6. 1999
  5. ncbi A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever
    M Bray
    Division of Virology, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702 5011, USA
    J Infect Dis 179:S248-58. 1999
  6. ncbi The pathogenesis of Ebola hemorrhagic fever
    A Takada
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    Trends Microbiol 9:506-11. 2001
  7. ncbi Laboratory diagnosis of Ebola hemorrhagic fever during an outbreak in Yambio, Sudan, 2004
    Clayton O Onyango
    World Health Organization Collaborating Center for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Nairobi, Kenya
    J Infect Dis 196:S193-8. 2007
  8. ncbi A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever
    M Bray
    Division of Virology, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702 5011, USA
    J Infect Dis 178:651-61. 1998
  9. ncbi Identification of the Ebola virus glycoprotein as the main viral determinant of vascular cell cytotoxicity and injury
    Z Y Yang
    Vaccine Research Center, National Institutes of Health, 40 Convent Drive, Bethesda, Maryland 20892 3005, USA
    Nat Med 6:886-9. 2000
  10. pmc Wild animal mortality monitoring and human Ebola outbreaks, Gabon and Republic of Congo, 2001-2003
    Pierre Rouquet
    Centre International de Recherches Medicales de Franceville, CIRMF BP 769, Franceville, Gabon
    Emerg Infect Dis 11:283-90. 2005

Detail Information

Publications196 found, 100 shown here

  1. ncbi Fruit bats as reservoirs of Ebola virus
    Eric M Leroy
    Centre International de Recherches Medicales de Franceville, BP 769 Franceville, Gabon
    Nature 438:575-6. 2005
    ..We find evidence of asymptomatic infection by Ebola virus in three species of fruit bat, indicating that these animals may be acting as a reservoir for this deadly virus...
  2. ncbi Ebola outbreak killed 5000 gorillas
    Magdalena Bermejo
    Ecosystèmes Forestiers d Afrique Centrale ECOFAC, Box Postale 15115 Libreville, Gabon
    Science 314:1564. 2006
    ..The lag between neighboring gorilla groups in mortality onset was close to the ZEBOV disease cycle length, evidence that group-to-group transmission has amplified gorilla die-offs...
  3. ncbi Ebola virus: new insights into disease aetiopathology and possible therapeutic interventions
    Thomas W Geisbert
    Department of Viral Pathology and Ultrastructure, Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Expert Rev Mol Med 6:1-24. 2004
    ..This review summarises our current understanding of EBOV pathogenesis and discusses various approaches to therapeutic intervention based on our current understanding of how EBOV produces a lethal infection...
  4. ncbi Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients
    S Baize
    Centre International de Recherches Medicales de Franceville, Gabon
    Nat Med 5:423-6. 1999
    ..Thus, events very early in Ebola virus infection determine the control of viral replication and recovery or catastrophic illness and death...
  5. ncbi A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever
    M Bray
    Division of Virology, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702 5011, USA
    J Infect Dis 179:S248-58. 1999
    ..Mice injected peripherally with mouse-adapted or intraperitoneally with non-adapted EBO-Z virus resisted subsequent challenge with mouse-adapted virus...
  6. ncbi The pathogenesis of Ebola hemorrhagic fever
    A Takada
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    Trends Microbiol 9:506-11. 2001
    ....
  7. ncbi Laboratory diagnosis of Ebola hemorrhagic fever during an outbreak in Yambio, Sudan, 2004
    Clayton O Onyango
    World Health Organization Collaborating Center for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Nairobi, Kenya
    J Infect Dis 196:S193-8. 2007
    Between the months of April and June 2004, an Ebola hemorrhagic fever (EHF) outbreak was reported in Yambio county, southern Sudan...
  8. ncbi A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever
    M Bray
    Division of Virology, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702 5011, USA
    J Infect Dis 178:651-61. 1998
    ..Mice injected peripherally with mouse-adapted or intraperitoneally with non-adapted EBO-Z virus resisted subsequent challenge with mouse-adapted virus...
  9. ncbi Identification of the Ebola virus glycoprotein as the main viral determinant of vascular cell cytotoxicity and injury
    Z Y Yang
    Vaccine Research Center, National Institutes of Health, 40 Convent Drive, Bethesda, Maryland 20892 3005, USA
    Nat Med 6:886-9. 2000
    ..These findings indicate that GP, through its mucin domain, is the viral determinant of Ebola pathogenicity and likely contributes to hemorrhage during infection...
  10. pmc Wild animal mortality monitoring and human Ebola outbreaks, Gabon and Republic of Congo, 2001-2003
    Pierre Rouquet
    Centre International de Recherches Medicales de Franceville, CIRMF BP 769, Franceville, Gabon
    Emerg Infect Dis 11:283-90. 2005
    ..Wild animal outbreaks began before each of the 5 human Ebola outbreaks. Twice we alerted the health authorities to an imminent risk for human outbreaks, weeks before they occurred...
  11. ncbi Human Ebola outbreak resulting from direct exposure to fruit bats in Luebo, Democratic Republic of Congo, 2007
    Eric M Leroy
    Centre International de Recherches Medicales de Franceville CIRMF, Franceville, Gabon
    Vector Borne Zoonotic Dis 9:723-8. 2009
    ..These findings support the suspected role of bats in the natural cycle of Ebola virus and indicate that the massive seasonal fruit bat migrations should be taken into account in operational Ebola risk maps and seasonal alerts in the DRC...
  12. ncbi Defense against filoviruses used as biological weapons
    Mike Bray
    Medical Officer, Biodefense Clinical Research Branch, OCR OD NIAID NIH, 6700A Rockledge Drive, Room 5132, Bethesda, MD 20892, USA
    Antiviral Res 57:53-60. 2003
    ..Terrorists might have great difficulty acquiring a filovirus for use as a weapon, but my attempt to do so because of the agents' ability to inspire fear. Accurate information is the best tool to prevent panic in the event of an attack...
  13. ncbi Ebola hemorrhagic fever and septic shock
    Mike Bray
    J Infect Dis 188:1613-7. 2003
  14. ncbi Ecology of Marburg and Ebola viruses: speculations and directions for future research
    T P Monath
    Research and Medical Affairs, OraVax, Inc, Cambridge Massachusetts 02139, USA
    J Infect Dis 179:S127-38. 1999
    ..Such viruses may have separate life cycles or may give rise to virulent strains by mutation...
  15. pmc Successful topical respiratory tract immunization of primates against Ebola virus
    Alexander Bukreyev
    Laboratory of Infectious Disease, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8007, USA
    J Virol 81:6379-88. 2007
    ..To our knowledge, this is the first study in which topical immunization through respiratory tract achieved prevention of a viral hemorrhagic fever infection in a primate model...
  16. ncbi An analysis of features of pathogenesis in two animal models of Ebola virus infection
    E I Ryabchikova
    State Research Center of Virology and Biotechnology Vector, Research Institute of Molecular Biology, Koltsovo, Russia
    J Infect Dis 179:S199-202. 1999
    ..The results show that species-specific features of monkeys must be taken into account when choosing an experimental model for studying Ebola virus infection...
  17. ncbi Pathogenesis of experimental Ebola Zaire virus infection in BALB/c mice
    T R Gibb
    Diagnostic Systems, United States Army Medical Research Institute of Infectious Diseases (USAMRIID, Fort Detrick, Frederick, Maryland 21702-5011, USA
    J Comp Pathol 125:233-42. 2001
    ..The availability of immunodeficient, "gene-knockout" and transgenic mice will make the mouse model particularly useful for studying the early steps of Ebola pathogenesis...
  18. ncbi Transmission of Ebola hemorrhagic fever: a study of risk factors in family members, Kikwit, Democratic Republic of the Congo, 1995. Commission de Lutte contre les Epidémies à Kikwit
    S F Dowell
    Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 179:S87-91. 1999
    ..had been infected with Ebola virus were interviewed in order to define the modes of transmission of Ebola hemorrhagic fever (EHF). Of 173 household contacts of the primary cases, 28 (16%) developed EHF...
  19. pmc The temporal program of peripheral blood gene expression in the response of nonhuman primates to Ebola hemorrhagic fever
    Kathleen H Rubins
    Department of Microbiology and Immunology, 299 Campus Dr, Stanford University School of Medicine, Stanford, California 94305, USA
    Genome Biol 8:R174. 2007
    ..Infection with Ebola virus (EBOV) causes a fulminant and often fatal hemorrhagic fever. In order to improve our understanding of EBOV pathogenesis and EBOV-host interactions, we examined the molecular features of EBOV infection in vivo...
  20. pmc Induction of immune responses in mice and monkeys to Ebola virus after immunization with liposome-encapsulated irradiated Ebola virus: protection in mice requires CD4(+) T cells
    Mangala Rao
    Department of Membrane Biochemistry, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910 7500, USA
    J Virol 76:9176-85. 2002
    ..Although immunization of the monkeys with L(EV)-induced virus-neutralizing antibodies against EBO-Z caused a slight delay in the onset of illness, it did not prevent death...
  21. pmc Ebola hemorrhagic fever transmission and risk factors of contacts, Uganda
    Paolo Francesconi
    Istituto Superiore di Sanita, Rome, Italy
    Emerg Infect Dis 9:1430-7. 2003
    From August 2000 through January 2001, a large epidemic of Ebola hemorrhagic fever occurred in Uganda, with 425 cases and 224 deaths...
  22. ncbi A serological survey of Ebola virus infection in central African nonhuman primates
    E M Leroy
    Centre International de Recherches Medicales de Franceville, Institut de Recherche pour le Developpement, UR034, Franceville, Gabon
    J Infect Dis 190:1895-9. 2004
    ..They also suggest that future Ebola outbreaks may occur anywhere in the central African forest region...
  23. pmc Ebola virus can be effectively neutralized by antibody produced in natural human infection
    T Maruyama
    Departments of Immunology and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 73:6024-30. 1999
    ..The neutralizing antibody may be useful in vaccine design and as a prophylactic agent against Ebola virus infection...
  24. ncbi Detection and molecular characterization of Ebola viruses causing disease in human and nonhuman primates
    A Sanchez
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 179:S164-9. 1999
    ..Significant amounts of SGP were detected in acutely infected humans...
  25. pmc Isolation and phylogenetic characterization of Ebola viruses causing different outbreaks in Gabon
    M C Georges Courbot
    , Franceville, Gabon
    Emerg Infect Dis 3:59-62. 1997
    Three outbreaks of Ebola hemorrhagic fever have recently occurred in Gabon...
  26. ncbi Correlates of protective immunity for Ebola vaccines: implications for regulatory approval by the animal rule
    Nancy J Sullivan
    Biodefense Research Section, Bethesda, Maryland 20892, USA
    Nat Rev Microbiol 7:393-400. 2009
    ..This research provides a basis for bridging the gap from basic research to human vaccine responses in support of the licensing of vaccines through the animal rule...
  27. pmc Mucosal immunization of cynomolgus macaques with the VSVDeltaG/ZEBOVGP vaccine stimulates strong ebola GP-specific immune responses
    Xiangguo Qiu
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    PLoS ONE 4:e5547. 2009
    ..Zaire ebolavirus (ZEBOV) produces a lethal viral hemorrhagic fever in humans and non-human primates...
  28. ncbi Field investigations of an outbreak of Ebola hemorrhagic fever, Kikwit, Democratic Republic of the Congo, 1995: arthropod studies
    P Reiter
    Dengue Branch, Centers for Disease Control and Prevention, San Juan, Puerto Rico 00921 3200, USA
    J Infect Dis 179:S148-54. 1999
    During the final weeks of a 6-month epidemic of Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo, an extensive collection of arthropods was made in an attempt to learn more of the natural history of the disease...
  29. ncbi Human asymptomatic Ebola infection and strong inflammatory response
    E M Leroy
    Centre International de Recherches Medicales de Franceville, Gabon
    Lancet 355:2210-5. 2000
    ..We aimed to determine whether these individuals were indeed infected with Ebola virus, and how they maintained asymptomatic status...
  30. ncbi Ebola hemorrhagic fever: evaluation of passive immunotherapy in nonhuman primates
    Peter B Jahrling
    Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, MD, USA
    J Infect Dis 196:S400-3. 2007
    ..These data cast further doubt on the value of passive immunotherapy for the treatment of EBOV infection...
  31. ncbi Recombinant human activated protein C for the postexposure treatment of Ebola hemorrhagic fever
    Lisa E Hensley
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA
    J Infect Dis 196:S390-9. 2007
    ..The aim of this study was to test the efficacy of rhAPC as a potential treatment for ZHF...
  32. pmc Early immune responses accompanying human asymptomatic Ebola infections
    E M Leroy
    Centre International de Recherches Medicales de Franceville, BP 769, Franceville, Gabon
    Clin Exp Immunol 124:453-60. 2001
    ..Taken together, these findings improve our understanding about immune response during human asymptomatic Ebola infection, and throw new light on protection against Ebola virus...
  33. ncbi Catastrophic ape decline in western equatorial Africa
    Peter D Walsh
    Department of Ecology and Evolutionary Biology, Guyot Hall, Princeton, New Jersey 08540, USA
    Nature 422:611-4. 2003
    ..Without aggressive investments in law enforcement, protected area management and Ebola prevention, the next decade will see our closest relatives pushed to the brink of extinction...
  34. pmc Role of natural killer cells in innate protection against lethal ebola virus infection
    Kelly L Warfield
    United States Army Medical Research Institute of Infectious Diseases, 1425 Porter St, Frederick, MD 21702, USA
    J Exp Med 200:169-79. 2004
    ..This work should open new doors for better understanding of Ebola virus pathogenesis and direct the development of immunotherapeutics, which target the innate immune system, for treatment of Ebola virus infection...
  35. pmc Ecologic and geographic distribution of filovirus disease
    A Townsend Peterson
    Department of Ecology and Evolutionary Biology, University of Kansas, Lawrence, Kansas, USA
    Emerg Infect Dis 10:40-7. 2004
    ..This first large-scale ecologic analysis provides a framework for a more informed search for taxa that could constitute the natural reservoir for this virus family...
  36. ncbi Discovery of swine as a host for the Reston ebolavirus
    Roger W Barrette
    Foreign Animal Disease Diagnostic Laboratory, National Veterinary Services Laboratories, Animal and Plant Health Inspection Services, United States Department of Agriculture, Plum Island Animal Disease Center, New York, NY 11944, USA
    Science 325:204-6. 2009
    ....
  37. ncbi Potential for Ebola transmission between gorilla and chimpanzee social groups
    Peter D Walsh
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
    Am Nat 169:684-9. 2007
    Over the past decade Ebola hemorrhagic fever has emerged repeatedly in Gabon and Congo, causing numerous human outbreaks and massive die-offs of gorillas and chimpanzees. Why Ebola has emerged so explosively remains poorly understood...
  38. ncbi A search for Ebola virus in animals in the Democratic Republic of the Congo and Cameroon: ecologic, virologic, and serologic surveys, 1979-1980. Ebola Virus Study Teams
    J G Breman
    Smallpox Eradication Unit, World Health Organization, Geneva, Switzerland
    J Infect Dis 179:S139-47. 1999
    ..30 years after the first outbreak of Marburg virus disease in Germany and Yugoslavia and 20 years after Ebola hemorrhagic fever first occurred in central Africa, the natural history of filoviruses remains unknown...
  39. pmc Chimeric human parainfluenza virus bearing the Ebola virus glycoprotein as the sole surface protein is immunogenic and highly protective against Ebola virus challenge
    Alexander Bukreyev
    National Institute of Allergy and Infectious Diseases, Building 50, Room 6505, NIAID, National Institutes of Health, 50 South Dr MSC 8007, Bethesda, MD 20892 8007, USA
    Virology 383:348-61. 2009
    ..Despite the attenuation, the virus was highly immunogenic, and a single IN dose completely protected the animals against a highly lethal intraperitoneal challenge of guinea pig-adapted EBOV...
  40. ncbi Accelerated vaccination for Ebola virus haemorrhagic fever in non-human primates
    Nancy J Sullivan
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 40, Room 4502, MSC 3005, 40 Convent Drive, Bethesda, Maryland 20892 3005, USA
    Nature 424:681-4. 2003
    ..This accelerated vaccine provides an intervention that may help to limit the epidemic spread of Ebola, and is applicable to other viruses...
  41. ncbi Gorilla susceptibility to Ebola virus: the cost of sociality
    Damien Caillaud
    Curr Biol 16:R489-91. 2006
  42. pmc Infection of naive target cells with virus-like particles: implications for the function of ebola virus VP24
    Thomas Hoenen
    Institut fur Virologie, Philipps Universitat Marburg, Marburg, Germany
    J Virol 80:7260-4. 2006
    ..Here we describe a ZEBOV iVLP system which overcomes this limitation and show that VP24 is essential for the formation of a functional ribonucleoprotein complex...
  43. pmc The virion glycoproteins of Ebola viruses are encoded in two reading frames and are expressed through transcriptional editing
    A Sanchez
    Division of Viral and Ricketsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 93:3602-7. 1996
    ..This genetic stability may indicate that EBO viruses have coevolved with their natural reservoirs and do not change appreciably in the wild...
  44. ncbi Cutting edge: impairment of dendritic cells and adaptive immunity by Ebola and Lassa viruses
    Siddhartha Mahanty
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Immunol 170:2797-801. 2003
    ..These data represent the first evidence for a mechanism by which Ebola and Lassa viruses target DC to impair adaptive immunity...
  45. ncbi Ebola hemorrhagic fever, Democratic Republic of the Congo, 1995: determinants of survival
    R F Sadek
    Special Pathogens Branch, Centers for Disease Control and Prevention, USA
    J Infect Dis 179:S24-7. 1999
    In May 1995, an international team characterized and contained an outbreak of Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo...
  46. ncbi Search for the Ebola virus reservoir in Kikwit, Democratic Republic of the Congo: reflections on a vertebrate collection
    H Leirs
    Danish Pest Infestation Laboratory, Lyngby
    J Infect Dis 179:S155-63. 1999
    ..The epidemiology of Ebola hemorrhagic fever suggests that humans have only intermittent contact with the virus, which complicates selection of target ..
  47. ncbi A novel immunohistochemical assay for the detection of Ebola virus in skin: implications for diagnosis, spread, and surveillance of Ebola hemorrhagic fever. Commission de Lutte contre les Epidémies à Kikwit
    S R Zaki
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 179:S36-47. 1999
    Laboratory diagnosis of Ebola hemorrhagic fever (EHF) is currently performed by virus isolation and serology and can be done only in a few high-containment laboratories worldwide...
  48. ncbi Spatial and temporal patterns of Zaire ebolavirus antibody prevalence in the possible reservoir bat species
    X Pourrut
    Institut de Recherche pour le Developpement, UR178, Franceville, Gabon
    J Infect Dis 196:S176-83. 2007
    ..monstrosus females suggests virus transmission within bat populations through fighting and sexual contact. Our study, thus, helps to describe Ebola virus circulation in bats and offers some insight into the appearance of outbreaks...
  49. pmc Ebola virus antibody prevalence in dogs and human risk
    Loïs Allela
    Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    Emerg Infect Dis 11:385-90. 2005
    ..8%. A significant positive direct association existed between seroprevalence and the distances to the Ebola virus-epidemic area. This study suggests that dogs can be infected by Ebola virus and that the putative infection is asymptomatic...
  50. ncbi Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated with fatal Ebola virus infection
    F Villinger
    Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Infect Dis 179:S188-91. 1999
    The role of immune mechanisms in the pathogenesis of Ebola hemorrhagic fever (EHF) remains to be elucidated...
  51. ncbi Multiple Ebola virus transmission events and rapid decline of central African wildlife
    Eric M Leroy
    Institut de Recherche pour le Developpement, UR034, Centre International de Recherches Medicales de Franceville, BP 769 Franceville, Gabon
    Science 303:387-90. 2004
    ..Surveillance of animal mortality may help to predict and prevent human Ebola outbreaks...
  52. ncbi The contribution of the endothelium to the development of coagulation disorders that characterize Ebola hemorrhagic fever in primates
    Lisa E Hensley
    Virology Division, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA
    Thromb Haemost 94:254-61. 2005
    Recently, there have been substantial developments in the understanding of Ebola hemorrhagic fever pathogenesis, but there are still major gaps...
  53. pmc Ebola hemorrhagic fever associated with novel virus strain, Uganda, 2007-2008
    Joseph F Wamala
    Ministry of Heath, Kampala, Uganda
    Emerg Infect Dis 16:1087-92. 2010
    ....
  54. ncbi Ebola hemorrhagic fever: lessons from Kikwit, Democratic Republic of the Congo
    D L Heymann
    Division of Emerging and Other Communicable Diseases, World Health Organization WHO, Geneva, Switzerland
    J Infect Dis 179:S283-6. 1999
    The outbreak of Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo, clearly signaled an end to the days when physicians and researchers could work in relative obscurity on problems of international importance, and it ..
  55. ncbi Evaluation of immune globulin and recombinant interferon-alpha2b for treatment of experimental Ebola virus infections
    P B Jahrling
    United States Army Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702 5011, USA
    J Infect Dis 179:S224-34. 1999
    ..Effective treatment of Ebola infections may require a combination of drugs that inhibit viral replication in monocyte/macrophage-like cells while reversing the pathologic effects (e.g., coagulopathy) consequent to this replication...
  56. ncbi Lymphocyte death in a mouse model of Ebola virus infection
    Steven B Bradfute
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA
    J Infect Dis 196:S296-304. 2007
    ..In a mouse model of ZEBOV infection, lymphocyte death is a prominent finding; however, the mechanism of death and the lymphocyte subsets that are targeted remain unknown...
  57. ncbi Pathogenesis of filoviral haemorrhagic fevers
    Siddhartha Mahanty
    Malaria Vaccine Development Unit, at the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Lancet Infect Dis 4:487-98. 2004
    ..Recent studies in non-human primates have shown that blocking of certain host responses, such as the coagulation cascade, can result in reduced viral replication and improved host survival...
  58. ncbi Trigger events: enviroclimatic coupling of Ebola hemorrhagic fever outbreaks
    Jorge E Pinzon
    Biospheric Sciences Branch, Laboratory for Terrestrial Physics, National Aeronautics and Space Administration Goddard Space Flight Center, Greenbelt, MD 20771, USA
    Am J Trop Med Hyg 71:664-74. 2004
    ..data as a correlate of precipitation within tropical Africa and show that the majority of documented Ebola hemorrhagic fever outbreaks were closely associated with sharply drier conditions at the end of the rainy season...
  59. ncbi [Outbreak of Ebola hemorrhagic fever in the Republic of the Congo, 2003: a new strategy?]
    P Formenty
    Département des Maladies transmissibles, Surveillance et Action, Organisation mondiale de la Sante, Geneve, Suisse
    Med Trop (Mars) 63:291-5. 2003
    ..On June 5, the Minister of Health and Population of the Congo Republic officially declared that the outbreak of EHF was over in the Cuvette Ouest Region. The last case was recorded on April 22 in the small village of Ndjoukou...
  60. ncbi Mechanisms underlying coagulation abnormalities in ebola hemorrhagic fever: overexpression of tissue factor in primate monocytes/macrophages is a key event
    Thomas W Geisbert
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA 21702 5011
    J Infect Dis 188:1618-29. 2003
    ..Thus, chemotherapeutic strategies aimed at controlling overexpression of TF may ameliorate the effects of EBOV hemorrhagic fever...
  61. ncbi An outbreak of Ebola in Uganda
    S I Okware
    Uganda Ministry of Health, Kampala, Uganda
    Trop Med Int Health 7:1068-75. 2002
    ..Thus all levels of the community spontaneously demonstrated solidarity and response to public health interventions. Even in areas of relative insecurity, rebel abductions diminished considerably...
  62. ncbi Ebola virus-like particle-based vaccine protects nonhuman primates against lethal Ebola virus challenge
    Kelly L Warfield
    US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA
    J Infect Dis 196:S430-7. 2007
    ..We previously had demonstrated the protective efficacy of virus-like particle (VLP)-based vaccines against EBOV and MARV infection in rodents...
  63. ncbi Ebola hemorrhagic fever outbreaks in Gabon, 1994-1997: epidemiologic and health control issues
    A J Georges
    Centre International de Recherches Medicales de Franceville, Gabon
    J Infect Dis 179:S65-75. 1999
    ..1% in the base pairs. Sequencing also showed that all isolates were very similar to subtype Zaire EBO virus isolates from the Democratic Republic of the Congo...
  64. ncbi Monocyte-derived human macrophages and peripheral blood mononuclear cells infected with ebola virus secrete MIP-1alpha and TNF-alpha and inhibit poly-IC-induced IFN-alpha in vitro
    M Gupta
    Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Virology 284:20-5. 2001
    ..These data provide the first direct evidence of a role for macrophages in the pathogenesis to Ebola virus and suggest that Ebola virus can inhibit cellular antiviral mechanisms mediated by type I interferons...
  65. pmc Inflammatory responses in Ebola virus-infected patients
    S Baize
    Centre International de Recherches Medicales de Franceville CIRMF, Franceville, Gabon, France
    Clin Exp Immunol 128:163-8. 2002
    ..In contrast, defective inflammatory responses and massive monocyte/macrophage activation were associated with fatal outcome...
  66. pmc Wave-like spread of Ebola Zaire
    Peter D Walsh
    Max Planck Institute for Evolutionary Primatology, Leipzig, Germany
    PLoS Biol 3:e371. 2005
    ..Controlling the impact of Ebola on wild apes and human populations may be more feasible than previously recognized...
  67. ncbi Vaccine potential of Ebola virus VP24, VP30, VP35, and VP40 proteins
    J A Wilson
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, Maryland 21702-5011, USA
    Virology 286:384-90. 2001
    ..The demonstration that the VP proteins are capable of eliciting protective immune responses to EBOV-Z indicates that they may be important components of a vaccine designed to protect humans from Ebola hemorrhagic fever.
  68. ncbi Proinflammatory response during Ebola virus infection of primate models: possible involvement of the tumor necrosis factor receptor superfamily
    Lisa E Hensley
    Pathology Division, US Army Medical Research Institute of Infectious Diseases USAMRIID, Attn MCMR UIP D, 1425 Porter Street, Fort Detrick, MD 21702 5011, USA
    Immunol Lett 80:169-79. 2002
    ..Identification of cytokine/chemokine, nitric oxide, and reactive oxygen species involvement in the observed filoviral pathogenesis may lend insight into the rational design of therapeutic countermeasures of filoviral pathogenesis...
  69. ncbi Ebola virus: the role of macrophages and dendritic cells in the pathogenesis of Ebola hemorrhagic fever
    Mike Bray
    Biodefense Clinical Research Branch, Office of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Biochem Cell Biol 37:1560-6. 2005
    b>Ebola hemorrhagic fever is a severe viral infection characterized by fever, shock and coagulation defects...
  70. pmc A single intranasal inoculation with a paramyxovirus-vectored vaccine protects guinea pigs against a lethal-dose Ebola virus challenge
    Alexander Bukreyev
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Virol 80:2267-79. 2006
    ....
  71. ncbi Haematological, biochemical and coagulation changes in mice, guinea-pigs and monkeys infected with a mouse-adapted variant of Ebola Zaire virus
    M Bray
    Virology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID, Fort Detrick, Frederick, Maryland 21702-5011, USA
    J Comp Pathol 125:243-53. 2001
    ..It was noteworthy, however, that mouse-adaptation appeared to have resulted in a degree of attenuation for monkeys...
  72. pmc A DNA vaccine for Ebola virus is safe and immunogenic in a phase I clinical trial
    Julie E Martin
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes, Bethesda, MD 20892 3017, USA
    Clin Vaccine Immunol 13:1267-77. 2006
    ....
  73. pmc Enhanced protection against Ebola virus mediated by an improved adenovirus-based vaccine
    Jason S Richardson
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    PLoS ONE 4:e5308. 2009
    ..The immune response elicited by this improved expression cassette vector (Ad-CAGoptZGP) and its ability to afford protection against lethal ZEBOV challenge in mice was compared to the standard Ad-CMVZGP vector...
  74. pmc Protection from Ebola virus mediated by cytotoxic T lymphocytes specific for the viral nucleoprotein
    J A Wilson
    Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702-5011, USA
    J Virol 75:2660-4. 2001
    ..The demonstration that CTLs can prevent lethal Ebola virus infection affects vaccine development in that protective cellular immune responses may be required for optimal protection from Ebola virus...
  75. ncbi Postexposure protection of guinea pigs against a lethal ebola virus challenge is conferred by RNA interference
    Thomas W Geisbert
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702 5011, USA
    J Infect Dis 193:1650-7. 2006
    ..Here, we describe the development of a potential therapy for EBOV infection that is based on small interfering RNAs (siRNAs)...
  76. pmc Ebola virus glycoproteins induce global surface protein down-modulation and loss of cell adherence
    Graham Simmons
    Department of Microbiology, School of Medicine, University of Pennsylvania, 303A Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104 6076, USA
    J Virol 76:2518-28. 2002
    ..A number of other cell surface molecules, however, including major histocompatibility complex class I and the epidermal growth factor receptor, were also down-modulated, suggesting a global mechanism for surface molecule down-regulation...
  77. ncbi The ecology of Ebola virus
    Allison Groseth
    Special Pathogens Program, National Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington St, Winnipeg, MB R3E 3R2, Canada
    Trends Microbiol 15:408-16. 2007
    ....
  78. ncbi Ebola virus outbreak among wild chimpanzees living in a rain forest of Côte d'Ivoire
    P Formenty
    World Health Organization WHO Taï Forest Project, and Centre Suisse de recherches scientifiques, Abidjan, Cote d Ivoire
    J Infect Dis 179:S120-6. 1999
    ..A high mortality rate among apes tends to indicate that they are not the reservoir for the disease causing the illness. These points will have to be investigated by additional studies...
  79. ncbi Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys
    Thomas W Geisbert
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA
    Lancet 362:1953-8. 2003
    ..Here, we tested the notion that blockade of fVIIa/tissue factor is beneficial after infection with Ebola virus...
  80. pmc Ebola virus-like particles protect from lethal Ebola virus infection
    Kelly L Warfield
    US Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 100:15889-94. 2003
    ..Together, our data suggest that eVLPs represent a promising vaccine candidate for protection against Ebola virus infections and a much needed tool to examine the genesis and nature of immune responses to Ebola virus...
  81. ncbi Human infection due to Ebola virus, subtype Côte d'Ivoire: clinical and biologic presentation
    P Formenty
    World Health Organization and Polyclinique Internationale Sainte Anne Marie, Abidjan, Cote d Ivoire
    J Infect Dis 179:S48-53. 1999
    ..No serologic conversion was detected among contact persons in Côte d'Ivoire (n = 22) or Switzerland (n = 52), suggesting that infection-control precautions were satisfactory...
  82. pmc Gene-specific countermeasures against Ebola virus based on antisense phosphorodiamidate morpholino oligomers
    Kelly L Warfield
    US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA
    PLoS Pathog 2:e1. 2006
    ..The work described here may contribute to development of designer, "druggable" countermeasures for filoviruses and other microbial pathogens...
  83. ncbi Ebola virus ecology: a continuing mystery
    Heinz Feldmann
    Special Pathogens Program, National Microbiology Laboratory, Health Canada, Winnipeg, Manitoba R3E 3R2, Canada
    Trends Microbiol 12:433-7. 2004
  84. pmc Rapid diagnosis of Ebola hemorrhagic fever by reverse transcription-PCR in an outbreak setting and assessment of patient viral load as a predictor of outcome
    Jonathan S Towner
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 78:4330-41. 2004
    The largest outbreak on record of Ebola hemorrhagic fever (EHF) occurred in Uganda from August 2000 to January 2001. The outbreak was centered in the Gulu district of northern Uganda, with secondary transmission to other districts...
  85. pmc High prevalence of both humoral and cellular immunity to Zaire ebolavirus among rural populations in Gabon
    Pierre Becquart
    Unité des Maladies Virales Emergentes, Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    PLoS ONE 5:e9126. 2010
    ..These findings provide significant new insights into ZEBOV circulation and human exposure, and raise important questions as to the human pathogenicity of ZEBOV and the existence of natural protective immunization...
  86. pmc Immune protection of nonhuman primates against Ebola virus with single low-dose adenovirus vectors encoding modified GPs
    Nancy J Sullivan
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Med 3:e177. 2006
    ..GP can exert cytopathic effects on transfected cells in vitro, and multiple GP forms have been identified in nature, raising the question of which would be optimal for a human vaccine...
  87. ncbi The natural history of Ebola virus in Africa
    Xavier Pourrut
    Centre International de Recherches Medicales de Franceville, Gabon
    Microbes Infect 7:1005-14. 2005
    Several countries spanning the equatorial forest regions of Africa have had outbreaks of Ebola hemorrhagic fever over the last three decades...
  88. pmc Analysis of human peripheral blood samples from fatal and nonfatal cases of Ebola (Sudan) hemorrhagic fever: cellular responses, virus load, and nitric oxide levels
    Anthony Sanchez
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Virol 78:10370-7. 2004
    ....
  89. ncbi Conservation. Scientists say Ebola has pushed western gorillas to the brink
    Gretchen Vogel
    Science 317:1484. 2007
  90. ncbi Interventions to control virus transmission during an outbreak of Ebola hemorrhagic fever: experience from Kikwit, Democratic Republic of the Congo, 1995
    B Kerstiëns
    Medecins Sans Frontieres, Brussels, Belgium
    J Infect Dis 179:S263-7. 1999
    ..was believed to be a concurrent outbreak of bacillary dysentery and viral hemorrhagic fever (suspected Ebola hemorrhagic fever [EHF]) in the town of Kikwit, DRC. On 11 May, the MSF intervention team assessed Kikwit General Hospital...
  91. ncbi Epitopes involved in antibody-mediated protection from Ebola virus
    J A Wilson
    Virology Division, U S Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD 21702 5011, USA
    Science 287:1664-6. 2000
    ..The identification of protective mAbs has important implications for developing vaccines and therapies for Ebola virus...
  92. ncbi Assessment of a vesicular stomatitis virus-based vaccine by use of the mouse model of Ebola virus hemorrhagic fever
    Steven M Jones
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Canada
    J Infect Dis 196:S404-12. 2007
    ..In the present study, we used the mouse model for Ebola hemorrhagic fever to assess the safety and efficacy of a vaccine based on a live attenuated vesicular stomatitis virus ..
  93. ncbi Vaccine research efforts for filoviruses
    Mary Kate Hart
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD 21702 5011, USA
    Int J Parasitol 33:583-95. 2003
    ..The vaccine approaches discussed include DNA-based vaccines, and subunit vaccines vectored by adenovirus, alphavirus replicons, and vaccinia virus...
  94. pmc Recent common ancestry of Ebola Zaire virus found in a bat reservoir
    Roman Biek
    Center for Disease Ecology, Department of Biology, Emory University, Atlanta, Georgia, USA
    PLoS Pathog 2:e90. 2006
  95. pmc ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response
    Oxana A Malakhova
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Biol Chem 283:8783-7. 2008
    ..To our knowledge, this is the first example of a Ub-like protein with the ability to interfere with Ub-E2 and E3 interaction to inhibit protein ubiquitination...
  96. pmc Ebola virus pathogenesis: implications for vaccines and therapies
    Nancy Sullivan
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 40, Room 4502, MSC 3005, 40 Convent Drive, Bethesda, MD 20892 3005, USA
    J Virol 77:9733-7. 2003
  97. ncbi The glycoproteins of Marburg and Ebola virus and their potential roles in pathogenesis
    H Feldmann
    Institut fur Virologie, Philipps Universitat Marburg, Germany
    Arch Virol Suppl 15:159-69. 1999
    ..Whether the soluble glycoproteins GP1 and sGP interfere with the humoral immune response and other defense mechanisms remains to be determined...
  98. pmc Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection
    Thomas W Geisbert
    United States Army Medical Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Am J Pathol 163:2347-70. 2003
    ..The sequence of pathogenetic events identified in this study should provide new targets for rational prophylactic and chemotherapeutic interventions...
  99. ncbi Ebola virus: the search for vaccines and treatments
    J A Wilson
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702-5011, USA
    Cell Mol Life Sci 58:1826-41. 2001
    ..This review describes Ebola viruses, with a particular focus on the status of research efforts to develop vaccines and therapeutics and to identify the immune mechanisms of protection...
  100. pmc Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda
    Jonathan S Towner
    Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Pathog 4:e1000212. 2008
    ....
  101. pmc The strains of Ebola
    Christopher Mason
    CMAJ 178:1266-7. 2008

Research Grants23

  1. BORNA DISEASE VIRUS AND NEUROPSYCHIATRIC DISEASE
    WALTER LIPKIN; Fiscal Year: 2002
    ..This study will be the first to collect and process human sera and PBMC samples in clinical laboratories with no history of BDV research and dispense aliquots to a central laboratory for randomized, blinded analysis. ..
  2. Developing small molecule therapeutics for Ebola hemorrhagic fever virus
    Arnab Basu; Fiscal Year: 2013
    ..Identify EBOV inhibitors with in vitro ADME properties suitable for i.v. and oral dosing;and 5. Evaluate EBOV inhibitors in a guinea pig model of EBOV infection. ..
  3. The Promotion of Inflammation by Bacterial Sialidases After Influenza Infection
    NICHOLAS KORTEN BROWN; Fiscal Year: 2013
    ..key regulator of pathogen virulence in some of the most challenging infectious diseases, including AIDS, Ebola hemorrhagic fever, sepsis, and bacterial pneumonia secondary to influenza infection...
  4. Initiation of Nucleocapsid Assembly in Ebola virus
    SHARON CRARY; Fiscal Year: 2004
    b>Ebola hemorrhagic fever is among the deadliest of communicable diseases...
  5. Pathogen Discovery in Chronic Lung Disease by Mass Tag PCR and Microarray
    W Ian Lipkin; Fiscal Year: 2009
    ....
  6. Community-Based Approach to Designing an AIDS Program for HIV+ Mothers in India
    Adeline Nyamathi; Fiscal Year: 2008
    ..These findings will lead to future funding to actually develop and test a newly designed program. [unreadable] [unreadable] [unreadable]..
  7. NEURONAL ELECTROPHYSIOLOGY IN HIV DEMENTIA
    HOWARD GENDELMAN; Fiscal Year: 2001
    ....
  8. SELENOPROTEINS, NF-KB, AND HIV DISEASE IN IV DRUG USERS
    ETHAN TAYLOR; Fiscal Year: 2003
    ..The long- term goal is to establish a molecular basis for the use of Se supplements as a chemoprotectant in HIV+ drug users. ..
  9. A Staged Strategy for Virus Identification and Discovery
    W Ian Lipkin; Fiscal Year: 2005
    ..Our initial focus will be two chronic diseases where specific viral taxa are associated and potentially implicated in pathogenesis: bronchioalveolar cell carcinoma and amyotrophic lateral sclerosis. ..
  10. Lassa and Nipah Virus Interferon-Antagonists
    CHRISTOPHER BASLER; Fiscal Year: 2003
    ..abstract_text> ..
  11. A Staged Strategy for Virus Identification and Discovery
    WALTER LIPKIN; Fiscal Year: 2004
    ..Consistent with aims proposed in AI51292, our initial clinical application will be to analyze enteroviral serotypes implicated in human disease in North America. ..
  12. Blood Brain Barrier Physiology and HIV Dementia
    HOWARD GENDELMAN; Fiscal Year: 2007
    ..The data acquired could provide new insights and therapeutic intervention strategies for monocyte BBB trafficking during progressive HIV-1 infection in brain tissue. ..
  13. A DEVELOPMENTAL MODEL FOR AUTISM BASED ON CNS INFECTION
    WALTER LIPKIN; Fiscal Year: 2004
    ..4) Determine how opoptosis contributes to the neuropathology observed after neonatal infection. (5) Analyze regional changes in neurotransmitter systems following neonatal infection. ..
  14. TB/HIV RISK REDUCTION WITH HOMELESS AND DRUG ADDICTED
    Adeline Nyamathi; Fiscal Year: 2002
    ....
  15. INTERFERON IN MODULATING DENGUE VIRUS INFECTION
    Michael Diamond; Fiscal Year: 2002
    ....
  16. Training Program in Neurovirology
    HOWARD GENDELMAN; Fiscal Year: 2006
    ....
  17. Development of Novel Antiviral Agents VS West Nile Virus
    Michael Diamond; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  18. MOLECULAR ANALYSIS OF A NEUROTROPIC AGENT--BORNA VIRUS
    WALTER LIPKIN; Fiscal Year: 2002
    ....
  19. EBOLA VIRUS INTERFERON-ANTAGONISTS AND VIRULENCE
    CHRISTOPHER BASLER; Fiscal Year: 2003
    ..VP35 and VP24 may also prove to be attractive targets for new antiviral agents. Inhibition of anti-IFN factors may sensitize Ebola virus infected cells to the antiviral effects of IFN and may also enhance the effect of antiviral agents. ..
  20. Alcohol Use Reduction in Methadone Individuals with HCV
    Adeline Nyamathi; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  21. Mass Tag PCR Detection of Respiratory Pathogens
    W Ian Lipkin; Fiscal Year: 2004
    ..abstract_text> ..
  22. MODELING THE UNDERSTANDING OF CHILDHOOD ASTHMA
    Adrian Casillas; Fiscal Year: 2002
    ..The candidate will have access to equipment, supplies, and technical support from the sponsor's laboratory. ..
  23. CD4 Immune Reconstitution in SIV Infection
    Francois Villinger; Fiscal Year: 2007
    ..Results of these studies will form the basis for future immune reconstitution strategies in human HIV infected patients. ..