hepatitis e

Summary

Summary: Acute INFLAMMATION of the LIVER in humans; caused by HEPATITIS E VIRUS, a non-enveloped single-stranded RNA virus. Similar to HEPATITIS A, its incubation period is 15-60 days and is enterically transmitted, usually by fecal-oral transmission.

Top Publications

  1. pmc Bats worldwide carry hepatitis E virus-related viruses that form a putative novel genus within the family Hepeviridae
    Jan Felix Drexler
    Institute of Virology, University of Bonn Medical Centre, Bonn, Germany
    J Virol 86:9134-47. 2012
  2. ncbi Hepatitis E virus and chronic hepatitis in organ-transplant recipients
    Nassim Kamar
    Department of Nephrology, Dialysis, and Multiorgan Transplantation, Centre Hospitalier Universitaire, Rangueil, France
    N Engl J Med 358:811-7. 2008
  3. ncbi Pig liver sausage as a source of hepatitis E virus transmission to humans
    Philippe Colson
    Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Fédération de Bactériologie Hygiène Virologie, Centre Hospitalo Universitaire Timone, Marseille, France
    J Infect Dis 202:825-34. 2010
  4. ncbi A comparison of two commercially available anti-HEV IgG kits and a re-evaluation of anti-HEV IgG seroprevalence data in developed countries
    Richard Bendall
    Clinical Microbiology, Royal Cornwall Hospital Trust, Truro, United Kingdom
    J Med Virol 82:799-805. 2010
  5. ncbi Hepatitis E: an emerging awareness of an old disease
    R H Purcell
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892 8009, USA
    J Hepatol 48:494-503. 2008
  6. ncbi Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial
    Feng Cai Zhu
    Jiangsu Provincial Centre for Disease Control and Prevention, Nanjing, Jiangsu Province, China
    Lancet 376:895-902. 2010
  7. pmc Cross-species infection of pigs with a novel rabbit, but not rat, strain of hepatitis E virus isolated in the United States
    Caitlin M Cossaboom
    Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Polytechnic Institute and State University Virginia Tech, Blacksburg, Virginia, USA
    J Gen Virol 93:1687-95. 2012
  8. ncbi Hepatitis E
    Nassim Kamar
    Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Toulouse, France
    Lancet 379:2477-88. 2012
  9. ncbi Hepatitis E: an emerging infection in developed countries
    Harry R Dalton
    Peninsula College of Medicine and Dentistry, Royal Cornwall Hospital Trust, Truro, UK
    Lancet Infect Dis 8:698-709. 2008
  10. pmc Novel hepatitis E virus genotype in Norway rats, Germany
    Reimar Johne
    Federal Institute for Risk Assessment, Berlin, Germany
    Emerg Infect Dis 16:1452-5. 2010

Detail Information

Publications307 found, 100 shown here

  1. pmc Bats worldwide carry hepatitis E virus-related viruses that form a putative novel genus within the family Hepeviridae
    Jan Felix Drexler
    Institute of Virology, University of Bonn Medical Centre, Bonn, Germany
    J Virol 86:9134-47. 2012
    b>Hepatitis E virus (HEV) is one of the most common causes of acute hepatitis in tropical and temperate climates. Tropical genotypes 1 and 2 are associated with food-borne and waterborne transmission...
  2. ncbi Hepatitis E virus and chronic hepatitis in organ-transplant recipients
    Nassim Kamar
    Department of Nephrology, Dialysis, and Multiorgan Transplantation, Centre Hospitalier Universitaire, Rangueil, France
    N Engl J Med 358:811-7. 2008
    b>Hepatitis E virus (HEV) is considered an agent responsible for acute hepatitis that does not progress to chronic hepatitis...
  3. ncbi Pig liver sausage as a source of hepatitis E virus transmission to humans
    Philippe Colson
    Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Fédération de Bactériologie Hygiène Virologie, Centre Hospitalo Universitaire Timone, Marseille, France
    J Infect Dis 202:825-34. 2010
    The source and route of autochthonous hepatitis E virus (HEV) infections are not clearly established in industrialized countries despite evidence that it is a zoonosis in pigs...
  4. ncbi A comparison of two commercially available anti-HEV IgG kits and a re-evaluation of anti-HEV IgG seroprevalence data in developed countries
    Richard Bendall
    Clinical Microbiology, Royal Cornwall Hospital Trust, Truro, United Kingdom
    J Med Virol 82:799-805. 2010
    In developed countries, the incidence of hepatitis E virus (HEV) infection and the resulting seroprevalence are uncertain. Published estimates of seroprevalnce in these populations range from 0...
  5. ncbi Hepatitis E: an emerging awareness of an old disease
    R H Purcell
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892 8009, USA
    J Hepatol 48:494-503. 2008
    Although hepatitis E was recognized as a new disease in 1980, the virus was first visualized in 1983 and its genome was cloned and characterized in 1991, the disease is probably ancient but not recognized until modern times...
  6. ncbi Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial
    Feng Cai Zhu
    Jiangsu Provincial Centre for Disease Control and Prevention, Nanjing, Jiangsu Province, China
    Lancet 376:895-902. 2010
    Seroprevalence data suggest that a third of the world's population has been infected with the hepatitis E virus...
  7. pmc Cross-species infection of pigs with a novel rabbit, but not rat, strain of hepatitis E virus isolated in the United States
    Caitlin M Cossaboom
    Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Polytechnic Institute and State University Virginia Tech, Blacksburg, Virginia, USA
    J Gen Virol 93:1687-95. 2012
    b>Hepatitis E virus (HEV) is an important human pathogen. In addition to humans, HEV has also been identified in pig, chicken, mongoose, deer, rat, rabbit and fish. There are four recognized and two putative genotypes of mammalian HEV...
  8. ncbi Hepatitis E
    Nassim Kamar
    Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Toulouse, France
    Lancet 379:2477-88. 2012
    b>Hepatitis E virus (HEV) was discovered during the Soviet occupation of Afghanistan in the 1980s, after an outbreak of unexplained hepatitis at a military camp...
  9. ncbi Hepatitis E: an emerging infection in developed countries
    Harry R Dalton
    Peninsula College of Medicine and Dentistry, Royal Cornwall Hospital Trust, Truro, UK
    Lancet Infect Dis 8:698-709. 2008
    b>Hepatitis E is endemic in many developing countries where it causes substantial morbidity. In industrialised countries, it is considered rare, and largely confined to travellers returning from endemic areas...
  10. pmc Novel hepatitis E virus genotype in Norway rats, Germany
    Reimar Johne
    Federal Institute for Risk Assessment, Berlin, Germany
    Emerg Infect Dis 16:1452-5. 2010
    Human hepatitis E virus infections may be caused by zoonotic transmission of virus genotypes 3 and 4...
  11. pmc Hepatitis E virus in rabbits, Virginia, USA
    Caitlin M Cossaboom
    Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0913, USA
    Emerg Infect Dis 17:2047-9. 2011
    We identified hepatitis E virus (HEV) in rabbits in Virginia, USA. HEV RNA was detected in 14 (16%) of 85 serum samples and 13 (15%) of 85 fecal samples. Antibodies against HEV were detected in 31 (36%) of 85 serum samples...
  12. ncbi Evidence of person-to-person transmission of hepatitis E virus during a large outbreak in Northern Uganda
    Eyasu H Teshale
    Division of Viral Hepatitis, National Center for HIV, Hepatitis, STD, and TB Prevention, Atlanta, Georgia 301333, USA
    Clin Infect Dis 50:1006-10. 2010
    Outbreaks of infection with hepatitis E virus (HEV) are frequently attributed to contaminated drinking water, even if direct evidence for this is lacking.
  13. pmc Hepatitis E virus: animal reservoirs and zoonotic risk
    X J Meng
    Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg VA, USA
    Vet Microbiol 140:256-65. 2010
    b>Hepatitis E virus (HEV) is a small, non-enveloped, single-strand, positive-sense RNA virus of approximately 7.2kb in size...
  14. pmc Hepatitis E virus antibodies in blood donors, France
    Jean Michel Mansuy
    Hopital Purpan, Toulouse, France
    Emerg Infect Dis 17:2309-12. 2011
    Using a validated sensitive assay, we found hepatitis E virus (HEV) IgG in 52.5% of voluntary blood donors in southwestern France. This finding suggests HEV is highly endemic to this region...
  15. pmc From barnyard to food table: the omnipresence of hepatitis E virus and risk for zoonotic infection and food safety
    Xiang Jin Meng
    Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0913, USA
    Virus Res 161:23-30. 2011
    b>Hepatitis E virus (HEV) is an important but extremely understudied pathogen. The mechanisms of HEV replication and pathogenesis are poorly understood, and a vaccine against HEV is not yet available...
  16. pmc Time trend of the prevalence of hepatitis E antibodies among farmers and blood donors: a potential zoonosis in Denmark
    Peer B Christensen
    Department of Infectious Diseases, Odense University Hospital, Denmark
    Clin Infect Dis 47:1026-31. 2008
    Antibody to hepatitis E virus (anti-HEV) is prevalent in Western countries, where clinical hepatitis E is rarely reported. The aim of this study was to determine the prevalence of anti-HEV among Danish blood donors and Danish farmers...
  17. ncbi Zoonotic and foodborne transmission of hepatitis E virus
    Xiang Jin Meng
    Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA
    Semin Liver Dis 33:41-9. 2013
    b>Hepatitis E is an important disease in many developing countries of Asia and Africa with large explosive outbreaks and is also endemic with sporadic or cluster cases of hepatitis in many industrialized countries...
  18. pmc Profile of acute infectious markers in sporadic hepatitis E
    Shoujie Huang
    National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, China
    PLoS ONE 5:e13560. 2010
    Laboratory diagnosis of acute infection of hepatitis E virus (HEV) is commonly based on the detection of HEV RNA, IgM and/or rising IgG levels. However, the profile of these markers when the patients present have not been well determined...
  19. pmc Experimental infection of rabbits with rabbit and genotypes 1 and 4 hepatitis E viruses
    Hongxia Ma
    Department of Cellular Biology, National Institute for the Control of Pharmaceutical and Biological Products, Beijing, China
    PLoS ONE 5:e9160. 2010
    A recent study provided evidence that farmed rabbits in China harbor a novel hepatitis E virus (HEV) genotype...
  20. ncbi Structure of hepatitis E viral particle
    Yoshio Mori
    Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    Virus Res 161:59-64. 2011
    b>Hepatitis E is acute hepatitis caused by infection of hepatitis E virus (HEV) via a fecal-to-oral or zoonotic route. HEV is a small, non-enveloped virus containing positive strand RNA as a genome...
  21. ncbi Hepatitis E in Italy: a long-term prospective study
    Luisa Romano
    Dipartimento di Sanità Pubblica Microbiologia Virologia, Universita degli Studi di Milano, Via C Pascal 36, 20133 Milan, Italy
    J Hepatol 54:34-40. 2011
    In developed countries, hepatitis E is usually associated with travelling to endemic areas, but a growing number of sporadic cases are also seen in patients with no travel history...
  22. ncbi Longitudinal study of hepatitis E virus infection in Spanish farrow-to-finish swine herds
    Maribel Casas
    Centre de Recerca en Sanitat Animal CReSA, Bellaterra, Barcelona, Spain
    Vet Microbiol 148:27-34. 2011
    b>Hepatitis E is a zoonotic disease and is highly prevalent in European swine livestock...
  23. ncbi Sporadic acute or fulminant hepatitis E in Hokkaido, Japan, may be food-borne, as suggested by the presence of hepatitis E virus in pig liver as food
    Yasuyuki Yazaki
    Center for Gastroenterology, Kobayashi Hospital, Hokkaido 090 8567, Japan
    J Gen Virol 84:2351-7. 2003
    Among ten patients who contracted sporadic acute or fulminant hepatitis E between 2001 and 2002 in Hokkaido, Japan, nine (90 %) had a history of consuming grilled or undercooked pig liver 2-8 weeks before the disease onset...
  24. pmc Epidemiology and risk factors of incident hepatitis E virus infections in rural Bangladesh
    Alain B Labrique
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Am J Epidemiol 172:952-61. 2010
    b>Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis in the world. Most of South Asia is HEV endemic, with frequent seasonal epidemics of hepatitis E and continuous sporadic cases...
  25. pmc Hepatitis E outbreak on cruise ship
    Bengü Said
    Department of Gastrointestinal, Emerging and Zoonotic Infections, Health Protection Agency Centre for Infections, 61 Colindale Ave, London NW9 5EQ, UK
    Emerg Infect Dis 15:1738-44. 2009
    In 2008, acute hepatitis E infection was confirmed in 4 passengers returning to the United Kingdom after a world cruise...
  26. ncbi Study of cellular immune response against Hepatitis E virus (HEV)
    S B Prabhu
    Department of Pathology, All India Institute of Medical Sciences, New Delhi, India
    J Viral Hepat 18:587-94. 2011
    b>Hepatitis E virus infection (HEV) is a major cause of acute viral hepatitis in the developing world. The immunopathology of HEV infections has not yet been elucidated...
  27. ncbi The molecular epidemiology of hepatitis E virus infection
    Michael A Purdy
    Centers for Disease Control and Prevention, National Center for HIV Hepatitis STD TB Prevention, Division of Viral Hepatitis, Atlanta, GA 30333, USA
    Virus Res 161:31-9. 2011
    Molecular characterization of various hepatitis E virus (HEV) strains circulating among humans and animals (particularly swine, deer and boars) in different countries has revealed substantial genetic heterogeneity...
  28. ncbi Genetic variability and evolution of hepatitis E virus
    Hiroaki Okamoto
    Division of Virology, Department of Infection and Immunity, Jichi Medical University, School of Medicine, Tochigi Ken 329 0498, Japan
    Virus Res 127:216-28. 2007
    b>Hepatitis E virus (HEV) is the sole member of the genus Hepevirus in the family Hepeviridae...
  29. pmc Hepatitis E virus strains in rabbits and evidence of a closely related strain in humans, France
    Jacques Izopet
    Institut National de la Sante et de la Recherche Medicale, Toulouse, France
    Emerg Infect Dis 18:1274-81. 2012
    b>Hepatitis E virus (HEV) strains from rabbits indicate that these mammals may be a reservoir for HEVs that cause infection in humans...
  30. ncbi Serological diagnostics of hepatitis E virus infection
    Yury Khudyakov
    Centers for Disease Control and Prevention, National Center for HIV Hepatitis STD TB Prevention, Division of Viral Hepatitis, Atlanta, GA 30333, USA
    Virus Res 161:84-92. 2011
    Development of accurate diagnostic assays for the detection of serological markers of hepatitis E virus (HEV) infection remains challenging...
  31. ncbi High prevalence of rat hepatitis E virus in wild rats in China
    Wei Li
    Institute of Microbiology, Center for Diseases Control and Prevention of Guangdong province, 160 Qunxian Road, Dashi street, Panyu District, Guangzhou 511430, China
    Vet Microbiol 165:275-80. 2013
    ..in Zhanjiang city in China from December 2011 to September 2012 were investigated for the prevalence of rat hepatitis E virus (HEV) by exploring rat HEV-specific antibodies and RNA...
  32. pmc Hepatitis E virus genotype 3 in wild rats, United States
    Justin B Lack
    Department of Zoology, Oklahoma State University, Stillwater, Oklahoma 74075, USA
    Emerg Infect Dis 18:1268-73. 2012
    The role of rodents in the epidemiology of zoonotic hepatitis E virus (HEV) infection has been a subject of considerable debate. Seroprevalence studies suggest widespread HEV infection in commensal Rattus spp...
  33. pmc Transmission of hepatitis E virus from rabbits to cynomolgus macaques
    Peng Liu
    Department of Microbiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People s Republic of China
    Emerg Infect Dis 19:559-65. 2013
    The recent discovery of hepatitis E virus (HEV) strains in rabbits in the People's Republic of China and the United States revealed that rabbits are another noteworthy reservoir of HEV...
  34. ncbi Hepatitis E virus (HEV)-specific T-cell responses are associated with control of HEV infection
    Pothakamuri Venkata Suneetha
    Department of Gastroenterology Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Hepatology 55:695-708. 2012
    b>Hepatitis E virus (HEV) infection is usually self-limited but may lead to acute hepatitis and rarely to fulminant hepatic failure...
  35. ncbi The serological prevalence and genetic diversity of hepatitis E virus in farmed rabbits in China
    Yansheng Geng
    Graduate School of Peking Union Medical College, 9 Dongdansantiao, Beijing 100730, China
    Infect Genet Evol 11:476-82. 2011
    We identified and characterized a novel virus, designated rabbit hepatitis E virus (HEV), in rex rabbits farmed in China...
  36. ncbi Detection of hepatitis E virus (HEV) from porcine livers in Southeastern Germany and high sequence homology to human HEV isolates
    Jürgen J Wenzel
    Institute of Medical Microbiology and Hygiene, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    J Clin Virol 52:50-4. 2011
    b>Hepatitis E virus (HEV) has been identified as an emerging cause of infectious hepatitis over the last years in developed countries...
  37. pmc Standardization of hepatitis E virus (HEV) nucleic acid amplification technique-based assays: an initial study to evaluate a panel of HEV strains and investigate laboratory performance
    Sally A Baylis
    Paul Ehrlich Institut, Paul Ehrlich Strasse 51 59, D 63225 Langen, Germany
    J Clin Microbiol 49:1234-9. 2011
    The performance of hepatitis E virus (HEV) RNA nucleic acid amplification (NAT)-based assays has been investigated using a panel of HEV-containing plasma samples...
  38. ncbi Epidemiology of hepatitis E: current status
    Rakesh Aggarwal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Gastroenterol Hepatol 24:1484-93. 2009
    b>Hepatitis E, caused by infection with hepatitis E virus (HEV), is a common cause of acute hepatitis in areas with poor sanitation...
  39. ncbi Transmission routes and risk factors for autochthonous hepatitis E virus infection in Europe: a systematic review
    H C Lewis
    Department of Epidemiology, Statens Serum Institut, Copenhagen, Denmark
    Epidemiol Infect 138:145-66. 2010
    Increasing numbers of non-travel-associated hepatitis E virus (HEV) infections have been reported in Europe in recent years...
  40. ncbi Recent advances in Hepatitis E virus
    X J Meng
    Department of Biomedical Sciences and Pathobiology, Center for Molecular Medicine and Infectious Diseases, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA
    J Viral Hepat 17:153-61. 2010
    b>Hepatitis E virus (HEV), the causative agent of hepatitis E, belongs to the family Hepeviridae...
  41. ncbi Transfusion-transmitted hepatitis E in a 'nonhyperendemic' country
    E Boxall
    National Blood Service, Vincent Drive, Birmingham, UK
    Transfus Med 16:79-83. 2006
    Indigenous hepatitis E is increasingly recognized in developed countries, where it may be a zoonosis...
  42. ncbi Detection and characterization of infectious Hepatitis E virus from commercial pig livers sold in local grocery stores in the USA
    A R Feagins
    Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA
    J Gen Virol 88:912-7. 2007
    b>Hepatitis E virus (HEV) is a zoonotic pathogen of which pigs are reservoirs...
  43. ncbi Phylogenetic analysis of global hepatitis E virus sequences: genetic diversity, subtypes and zoonosis
    Ling Lu
    Division of Gastroenterology Hepatology, Department of Medicine, Kansas University Medical Center, Kansas City, Kansas 66160, USA
    Rev Med Virol 16:5-36. 2006
    ..Accordingly, a total of 24 subtypes (1a, 1b, 1c, 1d, 1e, 2a, 2b, 3a, 3b, 3c, 3d, 3e, 3f, 3g, 3h, 3i, 3j, 4a, 4b, 4c, 4d, 4e, 4f and 4g) were given...
  44. pmc Zoonotic hepatitis E: animal reservoirs and emerging risks
    Nicole Pavio
    Ecole Nationale Veterinaire d Alfort, 94704 Maisons Alfort, France
    Vet Res 41:46. 2010
    b>Hepatitis E virus (HEV) is responsible for enterically-transmitted acute hepatitis in humans with two distinct epidemiological patterns...
  45. pmc Cross-species infections of cultured cells by hepatitis E virus and discovery of an infectious virus-host recombinant
    Priyanka Shukla
    Section of Molecular Hepatitis, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:2438-43. 2011
    The RNA virus, hepatitis E virus (HEV) is the most or second-most important cause of acute clinical hepatitis in adults throughout much of Asia, the Middle East, and Africa...
  46. ncbi Analysis of the full-length genome of a hepatitis E virus isolate obtained from a wild boar in Japan that is classifiable into a novel genotype
    Masaharu Takahashi
    Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Shimotsuke shi, Tochigi Ken 329 0498, Japan
    J Gen Virol 92:902-8. 2011
    While performing a nationwide survey of hepatitis E virus (HEV) infection among 450 wild boars (Sus scrofa leucomystax) that had been captured in Japan between November 2005 and March 2010, we found 16 boars (3...
  47. pmc Molecular virology of hepatitis E virus
    Imran Ahmad
    Virology Group, International Centre for Genetic Engineering and Biotechnology ICGEB, Aruna Asaf Ali Marg, New Delhi, India
    Virus Res 161:47-58. 2011
    This review details the molecular virology of the hepatitis E virus (HEV)...
  48. ncbi Molecular biology and pathogenesis of hepatitis E virus
    Vivek Chandra
    Virology Group, International Centre for Genetic Engineering and Biotechnology ICGEB, New Delhi 110 067, India
    J Biosci 33:451-64. 2008
    The hepatitis E virus (HEV) is a small RNA virus and the etiological agent for hepatitis E, a form of acute viral hepatitis...
  49. ncbi Seroprevalence of hepatitis E virus in Hong Kong, 2008-2009
    Diana M Y Chiu
    Virology Division, Public Health Laboratory Services Branch, Centre for Health Protection, Department of Health, Government of Hong Kong Special Administrative Region, China
    J Med Virol 85:459-61. 2013
    The public health impact of hepatitis E virus (HEV) infection varies across the world. An HEV vaccine has been recently approved for clinical use in China...
  50. ncbi Fatal outbreaks of jaundice in pregnancy and the epidemic history of hepatitis E
    C G Teo
    Division of Viral Hepatitis, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    Epidemiol Infect 140:767-87. 2012
    ..Documentation of the peculiar, fatal predisposition of pregnant women during outbreaks of jaundice identifies hepatitis E and enables construction of its epidemic history...
  51. ncbi A nationwide survey of hepatitis E virus infection in the general population of Japan
    Masaharu Takahashi
    Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Tochigi ken, Japan
    J Med Virol 82:271-81. 2010
    To investigate nationwide the prevalence of hepatitis E virus (HEV) infection in the general population of Japan, serum samples were collected from 22,027 individuals (9,686 males and 12,341 females; age, mean +/- standard deviation: 56...
  52. pmc Estimating the burden of maternal and neonatal deaths associated with jaundice in Bangladesh: possible role of hepatitis E infection
    Emily S Gurley
    International Centre for Diarrheal Diseases Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    Am J Public Health 102:2248-54. 2012
    We estimated the population-based incidence of maternal and neonatal mortality associated with hepatitis E virus (HEV) in Bangladesh.
  53. ncbi Rat hepatitis E virus: geographical clustering within Germany and serological detection in wild Norway rats (Rattus norvegicus)
    Reimar Johne
    Federal Institute for Risk Assessment, Berlin, Germany
    Infect Genet Evol 12:947-56. 2012
    Zoonotic hepatitis E virus (HEV) infection in industrialised countries is thought to be caused by transmission from wild boar, domestic pig and deer as reservoir hosts...
  54. pmc High hepatitis E virus seroprevalence in forestry workers and in wild boars in France
    Audrey Carpentier
    1 INRA UMR 1282, Tours, and Université F Rabelais, Tours, France
    J Clin Microbiol 50:2888-93. 2012
    b>Hepatitis E virus (HEV) is a fecally and orally transmitted human pathogen of worldwide distribution. In industrial countries, HEV is observed in an increasing number of autochthonous cases and is considered to be an emerging pathogen...
  55. pmc Hepatitis E virus in pork production chain in Czech Republic, Italy, and Spain, 2010
    Ilaria di Bartolo
    Istituto Superiore di Sanita, Rome, Italy
    Emerg Infect Dis 18:1282-9. 2012
    We evaluated the prevalence of hepatitis E virus (HEV) in the pork production chain in Czech Republic, Italy, and Spain during 2010...
  56. ncbi Hepatitis E seroprevalence and seroconversion among US military service members deployed to Afghanistan
    Angelia Eick
    Armed Forces Health Surveillance Center, Silver Spring, Maryland 20910, USA
    J Infect Dis 202:1302-8. 2010
    b>Hepatitis E virus (HEV) has been recognized as a threat to military forces since its discovery. Although HEV seroprevalence in Afghanistan is not known, HEV infection is thought to be highly endemic in that country...
  57. ncbi Molecular virology of hepatitis E virus
    R Prasida Holla
    Virology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
    Semin Liver Dis 33:3-14. 2013
    b>Hepatitis E virus (HEV) is the causative agent of hepatitis E. It is a nonenveloped virus with a ∼7.2 kilobases positive-stranded RNA genome...
  58. ncbi Seroprevalence for hepatitis E virus (HEV) infection among volunteer blood donors of the Regional Blood Bank of Londrina, State of Paraná , Brazil
    André Luiz Bortoliero
    Department of Internal Medicine, Health Sciences Center, Londrina State University, Londrina, Parana, Brazil
    Rev Inst Med Trop Sao Paulo 48:87-92. 2006
    ..out among 996 volunteer blood donors enrolled from May 1999 to December 1999 to determine the seroprevalence of hepatitis E virus (HEV) infection among volunteer blood donors of the Regional Blood Bank of Londrina, State of Paraná, ..
  59. pmc Detection by reverse transcription-PCR and genetic characterization of field isolates of swine hepatitis E virus from pigs in different geographic regions of the United States
    F F Huang
    Center for Molecular Medicine and Infectious Diseases, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0342, USA
    J Clin Microbiol 40:1326-32. 2002
    b>Hepatitis E virus (HEV) is an important public health concern in many developing countries. HEV is also endemic in some industrialized counties, including the United States...
  60. pmc Structural basis for the neutralization and genotype specificity of hepatitis E virus
    Xuhua Tang
    Department of Biological Sciences, National University of Singapore, Singapore 117543
    Proc Natl Acad Sci U S A 108:10266-71. 2011
    b>Hepatitis E virus (HEV) causes acute hepatitis in humans, predominantly by contamination of food and water, and is characterized by jaundice and flu-like aches and pains...
  61. ncbi Phylogenetic analysis of 626 hepatitis E virus (HEV) isolates from humans and animals in China (1986-2011) showing genotype diversity and zoonotic transmission
    Peng Liu
    Department of Microbiology, School of Basic Medical Sciences, Peking University, Peking University Infectious Disease Center, Beijing 100191, China
    Infect Genet Evol 12:428-34. 2012
    b>Hepatitis E is considered as a public health problem in China...
  62. ncbi A case of transfusion-transmitted hepatitis E caused by blood from a donor infected with hepatitis E virus via zoonotic food-borne route
    Keiji Matsubayashi
    Hokkaido Red Cross Blood Center, Sapporo, Japan
    Transfusion 48:1368-75. 2008
    Five cases of transfusion transmission of hepatitis E virus (HEV) have been reported so far. The infection routes of the causative donors remain unclear, however...
  63. ncbi Hepatitis E in new zealand
    Harry R Dalton
    Gastroenterology Unit, Auckland City Hospital, Auckland, New Zealand
    J Gastroenterol Hepatol 22:1236-40. 2007
    Locally acquired hepatitis E virus (HEV) infection has been described in a number of developed countries and is thought to be zoonotic from pigs...
  64. ncbi Epidemic of hepatitis E in a military unit in Abbotrabad, Pakistan
    Joe P Bryan
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
    Am J Trop Med Hyg 67:662-8. 2002
    An outbreak of hepatitis caused by hepatitis E virus (HEV) in Abbottabad, Pakistan was traced to fecal contamination of a water system...
  65. pmc Hepatitis E virus and neurologic disorders
    Nassim Kamar
    Department of Nephrology, Dialysis and Organ Transplantation, Centre Hospitalier Universitaire Rangueil, Toulouse, France
    Emerg Infect Dis 17:173-9. 2011
    Information about the spectrum of disease caused by hepatitis E virus (HEV) genotype 3 is emerging...
  66. ncbi Peripheral T regulatory cells and cytokines in hepatitis E infection
    A S Tripathy
    Hepatitis Group, National Institute of Virology, 130 1, Sus Road, Pashan, Pune, Maharashtra 411021, India
    Eur J Clin Microbiol Infect Dis 31:179-84. 2012
    This study addresses the involvement of regulatory T cells in hepatitis E (HE) infection. The study population comprised 77 acute viral HE patients, 52 recovered individuals (overall, 129 individuals with HE) and 53 healthy controls...
  67. ncbi International collaborative survey on epidemiology of hepatitis E virus in 11 countries
    Kenji Abe
    Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
    Southeast Asian J Trop Med Public Health 37:90-5. 2006
    We conducted seroepidemiological studies on antibody prevalence to hepatitis E virus (HEV) in 5,233 sera from 11 countries to ascertain the present state of HEV infection on a global basis...
  68. ncbi Immunopathogenesis of hepatitis E virus infection
    Heiner Wedemeyer
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Semin Liver Dis 33:71-8. 2013
    The course of hepatitis E virus infection (HEV) can vary substantially between different individuals...
  69. ncbi Hepatitis E virus seroprevalence and risk factors for individuals in working contact with animals
    Hélène Chaussade
    CHRU de Tours, Service de Médecine Interne and Maladies Infectieuses, 2 boulevard Tonnelle, 37044 Tours cedex 9, France
    J Clin Virol 58:504-8. 2013
    ....
  70. pmc Restricted enzooticity of hepatitis E virus genotypes 1 to 4 in the United States
    Chen Dong
    Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Clin Microbiol 49:4164-72. 2011
    b>Hepatitis E is recognized as a zoonosis, and swine are known reservoirs, but how broadly enzootic its causative agent, hepatitis E virus (HEV), is remains controversial...
  71. pmc Close similarity between sequences of hepatitis E virus recovered from humans and swine, France, 2008-2009
    Jerome Bouquet
    Anses, Laboratoire de Sante Animale, Maisons Alfort, France
    Emerg Infect Dis 17:2018-25. 2011
    Frequent zoonotic transmission of hepatitis E virus (HEV) has been suspected, but data supporting the animal origin of autochthonous cases are still sparse...
  72. ncbi Phylogenetic analysis of the full genome of rabbit hepatitis E virus (rbHEV) and molecular biologic study on the possibility of cross species transmission of rbHEV
    Jiabao Geng
    Institute of Hepatology, the 81st Hospital of PLA, Nanjing, Jiangsu Province, China
    Infect Genet Evol 11:2020-5. 2011
    ..positions as possibly being involved in specifying the host range of HEV and/or in determining the severity of hepatitis E disease, whereas this previous analysis did not extend to the new rabbit HEVs...
  73. pmc Deletions of the hypervariable region (HVR) in open reading frame 1 of hepatitis E virus do not abolish virus infectivity: evidence for attenuation of HVR deletion mutants in vivo
    R S Pudupakam
    Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, 1410 Price s Fork Road, Blacksburg, VA 24061 0342, USA
    J Virol 83:384-95. 2009
    b>Hepatitis E virus (HEV) is an important human pathogen, although little is known about its biology and replication...
  74. ncbi Phylogenetic and case-control study on hepatitis E virus infection in Germany
    Ole Wichmann
    Department of Infectious Disease Epidemiology, Robert Koch Institute, Germany
    J Infect Dis 198:1732-41. 2008
    b>Hepatitis E is a classic water-borne disease in developing countries. In Germany, hepatitis E virus (HEV) infections are notifiable...
  75. ncbi Monoclonal antibodies raised against the ORF3 protein of hepatitis E virus (HEV) can capture HEV particles in culture supernatant and serum but not those in feces
    Masaharu Takahashi
    Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, 3311 1 Yakushiji, Shimotsuke shi, Tochigi Ken 329 0498, Japan
    Arch Virol 153:1703-13. 2008
    ..a synthetic peptide corresponding to the well-conserved, C-terminal 24-amino acid portion of ORF3 protein of hepatitis E virus (HEV) were produced and characterized...
  76. pmc Prevalence of hepatitis E virus in Chinese blood donors
    Qing Shun Guo
    National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen 361005, China
    J Clin Microbiol 48:317-8. 2010
    A point prevalence study of hepatitis E virus (HEV) in Chinese blood donors was conducted, and the prevalences of antibodies against HEV immunoglobulin G (IgG) and IgM among Chinese blood donors were 32.60% and 0.94%, respectively...
  77. ncbi The two faces of hepatitis E virus
    Eyasu H Teshale
    National Center for HIV, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Clin Infect Dis 51:328-34. 2010
    b>Hepatitis E virus (HEV) has at least 2 distinct epidemiological profiles: (1) large outbreaks and epidemics in developing countries, usually caused by HEV genotype 1, resulting in high morbidity and mortality among pregnant women and ..
  78. pmc Acute hepatitis E infection accounts for some cases of suspected drug-induced liver injury
    Timothy J Davern
    Department of Transplantation, California Pacific Medical Center, San Francisco, California, USA
    Gastroenterology 141:1665-72.e1-9. 2011
    ..b>Hepatitis E virus (HEV) infection has been proposed as another cause of suspected drug-induced liver disease...
  79. ncbi Liver transplant from a donor with occult HEV infection induced chronic hepatitis and cirrhosis in the recipient
    B Schlosser
    Department of Gastroenterology and Hepatology, Charite University Medicine, Campus Virchow Klinikum, Berlin, Germany
    J Hepatol 56:500-2. 2012
    Acute hepatitis E virus (HEV) infection is a self-limiting symptomatic or asymptomatic disease...
  80. ncbi The global burden of hepatitis E virus genotypes 1 and 2 in 2005
    David B Rein
    NORC at the University of Chicago, Atlanta, GA 30306, USA
    Hepatology 55:988-97. 2012
    We estimated the global burden of hepatitis E virus (HEV) genotypes 1 and 2 in 2005...
  81. pmc Hepatitis E virus in rats, Los Angeles, California, USA
    Robert H Purcell
    National Institutes of Health, Bethesda, Maryland, USA
    Emerg Infect Dis 17:2216-22. 2011
    The role of rats in human hepatitis E virus (HEV) infections remains controversial. A genetically distinct HEV was recently isolated from rats in Germany, and its genome was sequenced...
  82. pmc Hepatitis E Virus seroprevalence and chronic infections in patients with HIV, Switzerland
    Alain Kenfak-Foguena
    Centre Hospitalier Universitaire Vaudois and Lausanne University, Lausanne, Switzerland
    Emerg Infect Dis 17:1074-8. 2011
    We screened 735 HIV-infected patients in Switzerland with unexplained alanine aminotransferase elevation for hepatitis E virus (HEV) immunoglobulin G. Although HEV seroprevalence in this population is low (2...
  83. pmc Hepatitis E virus infection in central China reveals no evidence of cross-species transmission between human and swine in this area
    Wen Zhang
    School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai, People s Republic of China
    PLoS ONE 4:e8156. 2009
    b>Hepatitis E virus (HEV) is a zoonotic pathogen of which several species of animal were reported as reservoirs...
  84. ncbi Chronic hepatitis E virus infection in liver transplant recipients
    Elizabeth B Haagsma
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, The Netherlands
    Liver Transpl 14:547-53. 2008
    b>Hepatitis E virus (HEV) infection is known to run a self-limiting course. Sporadic cases of acute hepatitis due to infection with HEV genotype 3, present in pig populations, are increasingly recognized...
  85. ncbi Hepatitis E virus
    Mohammad S Khuroo
    Digestive Disease Centre, Dr Khuroo s Medical Clinic, Srinagar, India
    Curr Opin Infect Dis 21:539-43. 2008
    b>Hepatitis E is an emerging infectious disease. This review will focus on recent advances in the zoonotic transmission, global distribution and control of hepatitis E.
  86. pmc Polyphyletic strains of hepatitis E virus are responsible for sporadic cases of acute hepatitis in Japan
    Hitoshi Mizuo
    Department of Internal Medicine, Kin ikyo chuo Hospital, Hokkaido 007 0870, Japan
    J Clin Microbiol 40:3209-18. 2002
    ..and 2001 at five hospitals in Japan, 11 (13%) patients were positive for immunoglobulin M-class antibodies to hepatitis E virus (HEV) by enzyme immunoassay and had detectable HEV RNA by reverse transcription-PCR with two independent ..
  87. pmc Clinical and epidemiological relevance of quantitating hepatitis E virus-specific immunoglobulin M
    Jitvimol Seriwatana
    Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    Clin Diagn Lab Immunol 9:1072-8. 2002
    Diagnosis of acute hepatitis E by detection of hepatitis E virus (HEV)-specific immunoglobulin M (IgM) is an established procedure...
  88. ncbi Serologic assays specific to immunoglobulin M antibodies against hepatitis E virus: pangenotypic evaluation of performances
    Jan Drobeniuc
    Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Clin Infect Dis 51:e24-7. 2010
    Six immunoassays for detecting immunoglobulin M antibodies to hepatitis E virus were evaluated...
  89. pmc Release of genotype 1 hepatitis E virus from cultured hepatoma and polarized intestinal cells depends on open reading frame 3 protein and requires an intact PXXP motif
    Suzanne U Emerson
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, MSC 8009, Bethesda, MD 20892, USA
    J Virol 84:9059-69. 2010
    b>Hepatitis E virus genotype 1 strain Sar55 replicated in subcloned Caco-2 intestinal cells and Huh7 hepatoma cells that had been transfected with in vitro transcribed viral genomes, and hepatitis E virions were released into the culture ..
  90. pmc Use of serological assays for diagnosis of hepatitis E virus genotype 1 and 3 infections in a setting of low endemicity
    M Herremans
    National Institute for Public Health and the Environment, RIVM, Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Clin Vaccine Immunol 14:562-8. 2007
    Because of the occurrence of genotype 3 hepatitis E virus (HEV) in regions of low endemicity, it is important to validate the currently used serological assays for diagnosing infections with viruses belonging to this lineage, since these ..
  91. pmc Prevalence of antibodies to hepatitis E virus in veterinarians working with swine and in normal blood donors in the United States and other countries
    X J Meng
    Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0342, USA
    J Clin Microbiol 40:117-22. 2002
    b>Hepatitis E virus (HEV) is endemic in many developing and some industrialized countries. It has been hypothesized that animals may be the source of infection. The recent identification of swine HEV in U.S...
  92. pmc The nucleotides on the stem-loop RNA structure in the junction region of the hepatitis E virus genome are critical for virus replication
    Dianjun Cao
    Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0913, USA
    J Virol 84:13040-4. 2010
    The roles of conserved nucleotides on the stem-loop (SL) structure in the intergenic region of the hepatitis E virus (HEV) genome in virus replication were determined by using Huh7 cells transfected with HEV SL mutant replicons ..
  93. ncbi The incidence of hepatitis E virus infection in the general population of the USA
    M F Faramawi
    Epidemiology Department, School of Public Health, University of North Texas Health Science Center, Fort Worth, TX, USA
    Epidemiol Infect 139:1145-50. 2011
    b>Hepatitis E virus (HEV) infection is as an emerging disease of global importance because it is one of the major causes of acute hepatitis worldwide. There are few reports on the incidence of HEV in the USA...
  94. ncbi Factors associated with chronic hepatitis in patients with hepatitis E virus infection who have received solid organ transplants
    Nassim Kamar
    Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Toulouse, France
    Gastroenterology 140:1481-9. 2011
    b>Hepatitis E virus (HEV) infection can cause chronic hepatitis in recipients of solid organ transplants. However, the factors that contribute to chronic infection and the outcomes of these patients are incompletely understood...
  95. ncbi A systematic review/meta-analysis of primary research investigating swine, pork or pork products as a source of zoonotic hepatitis E virus
    B J Wilhelm
    Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, Guelph, Ontario, Canada
    Epidemiol Infect 139:1127-44. 2011
    ..of our study were to identify and categorize primary research investigating swine/pork as a source of zoonotic hepatitis E virus (HEV) using the relatively new technique of scoping study, and to investigate the potential association ..
  96. ncbi Acute hepatitis E virus infection in Taiwan 2002-2006 revisited: PCR shows frequent co-infection with multiple hepatitis viruses
    Kuan Ta Wu
    Department of General Medicine, Chi Mei Medical Center, Tainan, Taiwan
    J Med Virol 81:1734-42. 2009
    Sporadic cases of acute hepatitis E virus (HEV) infection with production of anti-HEV IgM have been reported occasionally in Taiwan despite no reported outbreaks in the past...
  97. pmc Identical consensus sequence and conserved genomic polymorphism of hepatitis E virus during controlled interspecies transmission
    Jerome Bouquet
    UMR 1161 Virology, Anses, Laboratoire de Sante Animale, Maisons Alfort, France
    J Virol 86:6238-45. 2012
    High-throughput sequencing of bile and feces from two pigs experimentally infected with human hepatitis E virus (HEV) of genotype 3f revealed the same full-length consensus sequence as in the human sample...
  98. ncbi Ribavirin therapy inhibits viral replication on patients with chronic hepatitis e virus infection
    Nassim Kamar
    Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Toulouse, France
    Gastroenterology 139:1612-8. 2010
    b>Hepatitis E virus (HEV) infection can evolve to chronic hepatitis in immunocompromised patients...
  99. ncbi Hepatitis E virus in Italy: molecular analysis of travel-related and autochthonous cases
    Giuseppina La Rosa
    Istituto Superiore di Sanita, Department of Environment and Primary Prevention, Rome, Italy
    J Gen Virol 92:1617-26. 2011
    Human hepatitis E virus (HEV) is considered an emerging pathogen in industrialized countries. The aim of the present study was to contribute to the body of knowledge available on the molecular epidemiology of acute hepatitis E in Italy...
  100. ncbi Hepatitis E virus excretion can be prolonged in patients with hematological malignancies
    Suzanne Tavitian
    Service d Hematologie, CHU de Toulouse, Hopital Purpan, Place du Dr Baylac, 31059 Toulouse Cedex, France
    J Clin Virol 49:141-4. 2010
    b>Hepatitis E virus (HEV) is transmitted via the fecal-oral route and locally acquired sporadic hepatitis E can occur in Western countries...
  101. ncbi Discovery of hepatitis E: the epidemic non-A, non-B hepatitis 30 years down the memory lane
    Mohammad Sultan Khuroo
    Gastroenterology, Digestive Diseases Centre, Kashmir, J and K, India
    Virus Res 161:3-14. 2011
    b>Hepatitis E was first recognised during an epidemic of hepatitis, which occurred in Kashmir Valley in 1978. The epidemic involved an estimated 52,000 cases of icteric hepatitis with 1700 deaths...

Research Grants24

  1. Present Homologous and Heterologous Antigen with Hepatitis E Virus
    R Holland Cheng; Fiscal Year: 2012
    ..Non-replicating virus-like particle derived from human hepatitis E virus (HEV-VLP) is empty icosahedral cage composed of 60 copies of recombinant HEV capsid proteins...
  2. Non-invasive zoonotic pathogen exposure and outcome biomarkers with follow-up in
    Christopher D Heaney; Fiscal Year: 2013
    ..Weber and Schmitz to develop, optimize and validate an ELISA for detection of hepatitis E virus (HEV) antibodies (anti-HEV) in saliva. For this purpose co-mentor Dr...
  3. Astrovirus structure and replication
    Yizhi Jane Tao; Fiscal Year: 2013
    ..Among the four plus-sense, single-stranded RNA viruses that infect human (i.e. picornaviruses, caliciviruses, hepatitis E viruses, and astroviruses), astroviruses are the least characterized ones...
  4. Mechanism of Hepatitis E Virus Replication and Pathogenesis
    Xiang Jin Meng; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hepatitis E virus (HEV) is an important but extremely understudied pathogen. Genotypes 1 and 2 are restricted to humans, whereas genotypes 3 and 4 infect humans and other animals...
  5. Incidence and Natural History of Hepatitis E Virus in Pregnant Bangladeshi Women
    ALAIN BERNARD LABRIQUE; Fiscal Year: 2010
    Over 2 million adult cases of hepatitis E virus (HEV) are thought to occur annually in India alone, and HEV accounts for the majority of acute viral hepatitis hospitalizations worldwide, yet accurate population-based estimates of HEV ..
  6. A Chicken Model to Study Hepatitis E Virus Pathogenesis
    Xiang Jin Meng; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hepatitis E is an important public health disease with a high mortality rate of up to 28% in infected pregnant women...
  7. Morpholino Antisense Drugs for Hepatitis E Virus
    Yan Jin Zhang; Fiscal Year: 2010
    b>Hepatitis E virus (HEV) causes endemic and large epidemics of acute human hepatitis and sporadic cases by a fecal-oral transmission in many parts of the world...
  8. MOLECULAR BIOLOGY OF RUBELLA VIRUS
    TERYL FREY; Fiscal Year: 2006
    ..pathogenesis and are of evolutionary interest in that, by computer alignment, they are more closely related to hepatitis E virus (HEV, an unclassified enteric virus) than to the alphaviruses, the other Togavirus genus...
  9. DETERMINANTS OF HEPATITIS C & E MORBIDITY IN EGYPT
    George Strickland; Fiscal Year: 2002
    ..been categorized into those infected with hepatitis C virus (HCV), a parenterally transmitted flavivirus, and hepatitis E virus (HEV), a fecal-oral transmitted "hepatitis E-like virus...
  10. DETERMINANTS OF HEPATITIS C & E MORBIDITY IN EGYPT
    George Strickland; Fiscal Year: 2004
    ..been categorized into those infected with hepatitis C virus (HCV), a parenterally transmitted flavivirus, and hepatitis E virus (HEV), a fecal-oral transmitted "hepatitis E-like virus...
  11. PATHOGENESIS OF THE HEPATITIS E VIRUS: A SWINE MODEL
    Xiang Jin Meng; Fiscal Year: 2000
    b>Hepatitis E virus (HEV), the causative agent of hepatitis E, is an important public health problem in developing countries. HEV is also considered to be endemic in the United States (U.S). HEV strains recovered from patients in the U.S...
  12. Cell-free Replication of Hepatitis E Virus
    Naushad Ali; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Hepatitis E Virus (HEV) is a leading cause of severe acute hepatitis worldwide and numerous outbreaks in the developing countries...
  13. ZOONOTIC AND XENOZOONOTIC RISKS OF HEPATITIS E VIRUS
    Xiang Jin Meng; Fiscal Year: 2001
    ..b>Hepatitis E virus (HEV), the causative agent of hepatitis E is an important human pathogen worldwide and causes very high ..
  14. Greater Sensitivity ELISA for HIV by Photoillumination
    MICHAEL MUEHLEMANN; Fiscal Year: 2001
    ..Coli, Samonella and a host of tumor markers. ..
  15. Towards Understanding the Morbidity of HEV Infection
    Mohamed Tarek Shata; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Hepatitis E (HEV) is enterically transmitted RNA virus that causes acute viral hepatitis (AVH) in many lesser developed countries (LDC), with frequent reports of fulminant hepatitis in ..
  16. Immune events, transcriptomics and biomarkers in hepatitis E pathogenesis
    Shahid Jameel; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hepatitis E, caused by infection with waterborne hepatitis E virus (HEV) is endemic in several developing countries, particularly in Asia and Africa...
  17. A MULTI-CENTER THERAPY TRIAL FOR ACUTE LIVER FAILURE
    William Lee; Fiscal Year: 2004
    ..The overall goal is to apply modern clinical, epidemiological and virological techniques to the study of this rare but devastating illness. ..
  18. Gastric Tube Placement in Young Children
    Marsha Ellett; Fiscal Year: 2008
    ..Results from this study will increase the safety of using gastric tubes in young children. ..
  19. Evaluation of the Control of HIV After a Prison Amnesty in Taiwan
    Kenrad Nelson; Fiscal Year: 2008
    ..unreadable] [unreadable] The collaboration is between the Bloomberg School of Public Health of Johns Hopkins University and the Center for Disease Control in Taiwan. [unreadable] [unreadable] [unreadable]..
  20. THE EPIDEMIOLOGY OF HEPATITIS C INFECTION IN THAILAND
    Kenrad Nelson; Fiscal Year: 2004
    ..Through the transfer of technology for HCV research to our collaborators, we hope to focus on understanding the biology and epidemiology of HCV and the development of more effective prevention of HCV. ..
  21. Epidemiology of Hep E Virus Infections in Bangladesh
    Kenrad Nelson; Fiscal Year: 2003
    b>Hepatitis E virus (HEV) infections cause serious morbidity and mortality, especially in pregnant women. Few population-based studies have characterized HEV epidemiology...
  22. Prevalence and Epidemiology of Hepatitis E Virus in the United States
    Kenrad Nelson; Fiscal Year: 2008
    b>Hepatitis E virus (HEV) is the etiologic agent responsible for large outbreaks of clinical hepatitis in developing countries and a large proportion of sporadic clinical hepatitis in developing countries...
  23. Extrahepatic Replication and Viral Evolution of HCV During HCV/HIV Co-infection
    Jason Blackard; Fiscal Year: 2007
    ..This proposal will provide important data on co-factors of virus transmission and identify potential markers of HCV disease progression and treatment failure. [unreadable] [unreadable] [unreadable]..