hepatitis e

Summary

Summary: Acute INFLAMMATION of the LIVER in humans; caused by HEPATITIS E VIRUS, a non-enveloped single-stranded RNA virus. Similar to HEPATITIS A, its incubation period is 15-60 days and is enterically transmitted, usually by fecal-oral transmission.

Top Publications

  1. ncbi Recent advances in Hepatitis E virus
    X J Meng
    Department of Biomedical Sciences and Pathobiology, Center for Molecular Medicine and Infectious Diseases, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA
    J Viral Hepat 17:153-61. 2010
  2. ncbi Transmission routes and risk factors for autochthonous hepatitis E virus infection in Europe: a systematic review
    H C Lewis
    Department of Epidemiology, Statens Serum Institut, Copenhagen, Denmark
    Epidemiol Infect 138:145-66. 2010
  3. ncbi Epidemiology of hepatitis E: current status
    Rakesh Aggarwal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Gastroenterol Hepatol 24:1484-93. 2009
  4. ncbi Hepatitis E virus and chronic hepatitis in organ-transplant recipients
    Nassim Kamar
    Department of Nephrology, Dialysis, and Multiorgan Transplantation, Centre Hospitalier Universitaire, Rangueil, France
    N Engl J Med 358:811-7. 2008
  5. ncbi Molecular biology and pathogenesis of hepatitis E virus
    Vivek Chandra
    Virology Group, International Centre for Genetic Engineering and Biotechnology ICGEB, New Delhi 110 067, India
    J Biosci 33:451-64. 2008
  6. ncbi Hepatitis E virus infection in central China reveals no evidence of cross-species transmission between human and swine in this area
    Wen Zhang
    School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai, People s Republic of China
    PLoS ONE 4:e8156. 2009
  7. ncbi Hepatitis E virus
    Mohammad S Khuroo
    Digestive Disease Centre, Dr Khuroo s Medical Clinic, Srinagar, India
    Curr Opin Infect Dis 21:539-43. 2008
  8. ncbi Chronic hepatitis E virus infection in liver transplant recipients
    Elizabeth B Haagsma
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, The Netherlands
    Liver Transpl 14:547-53. 2008
  9. ncbi Hepatitis E virus antibodies in hemodialysis patients: an epidemiological survey in central Greece
    I Stefanidis
    University of Thessalia, School of Medicine, Larissa Greece
    Int J Artif Organs 27:842-7. 2004
  10. ncbi Identification by phage display and characterization of two neutralizing chimpanzee monoclonal antibodies to the hepatitis E virus capsid protein
    D J Schofield
    Hepatitis Viruses, National Institutes of Health, Bethesda, Maryland 20852, USA
    J Virol 74:5548-55. 2000

Research Grants

  1. Prevalence and Epidemiology of Hepatitis E Virus in the United States
    Kenrad Nelson; Fiscal Year: 2007
  2. DETERMINANTS OF HEPATITIS C & E MORBIDITY IN EGYPT
    George Strickland; Fiscal Year: 2004
  3. MOLECULAR BIOLOGY OF RUBELLA VIRUS
    TERYL FREY; Fiscal Year: 2006
  4. MOLECULAR BIOLOGY OF RUBELLA VIRUS
    TERYL FREY; Fiscal Year: 2000
  5. CHARACTERIZATION OF HUMAN CALICIVIRUS
    Xi Jiang; Fiscal Year: 2001
  6. Immune events, transcriptomics and biomarkers in hepatitis E pathogenesis
    Shahid Jameel; Fiscal Year: 2010
  7. Immune events, transcriptomics and biomarkers in hepatitis E pathogenesis
    Shahid Jameel; Fiscal Year: 2007
  8. Cell-free Replication of Hepatitis E Virus
    Naushad Ali; Fiscal Year: 2006
  9. Longitudinal cohort of newly acquired HCV infection
    John Kaldor; Fiscal Year: 2007
  10. Mechanism of Hepatitis E Virus Replication and Pathogenesis
    Xiang Jin Meng; Fiscal Year: 2009

Detail Information

Publications225 found, 100 shown here

  1. ncbi Recent advances in Hepatitis E virus
    X J Meng
    Department of Biomedical Sciences and Pathobiology, Center for Molecular Medicine and Infectious Diseases, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA
    J Viral Hepat 17:153-61. 2010
    b>Hepatitis E virus (HEV), the causative agent of hepatitis E, belongs to the family Hepeviridae...
  2. ncbi Transmission routes and risk factors for autochthonous hepatitis E virus infection in Europe: a systematic review
    H C Lewis
    Department of Epidemiology, Statens Serum Institut, Copenhagen, Denmark
    Epidemiol Infect 138:145-66. 2010
    Increasing numbers of non-travel-associated hepatitis E virus (HEV) infections have been reported in Europe in recent years...
  3. ncbi Epidemiology of hepatitis E: current status
    Rakesh Aggarwal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Gastroenterol Hepatol 24:1484-93. 2009
    b>Hepatitis E, caused by infection with hepatitis E virus (HEV), is a common cause of acute hepatitis in areas with poor sanitation...
  4. ncbi Hepatitis E virus and chronic hepatitis in organ-transplant recipients
    Nassim Kamar
    Department of Nephrology, Dialysis, and Multiorgan Transplantation, Centre Hospitalier Universitaire, Rangueil, France
    N Engl J Med 358:811-7. 2008
    b>Hepatitis E virus (HEV) is considered an agent responsible for acute hepatitis that does not progress to chronic hepatitis...
  5. ncbi Molecular biology and pathogenesis of hepatitis E virus
    Vivek Chandra
    Virology Group, International Centre for Genetic Engineering and Biotechnology ICGEB, New Delhi 110 067, India
    J Biosci 33:451-64. 2008
    The hepatitis E virus (HEV) is a small RNA virus and the etiological agent for hepatitis E, a form of acute viral hepatitis...
  6. ncbi Hepatitis E virus infection in central China reveals no evidence of cross-species transmission between human and swine in this area
    Wen Zhang
    School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai, People s Republic of China
    PLoS ONE 4:e8156. 2009
    b>Hepatitis E virus (HEV) is a zoonotic pathogen of which several species of animal were reported as reservoirs...
  7. ncbi Hepatitis E virus
    Mohammad S Khuroo
    Digestive Disease Centre, Dr Khuroo s Medical Clinic, Srinagar, India
    Curr Opin Infect Dis 21:539-43. 2008
    b>Hepatitis E is an emerging infectious disease. This review will focus on recent advances in the zoonotic transmission, global distribution and control of hepatitis E.
  8. ncbi Chronic hepatitis E virus infection in liver transplant recipients
    Elizabeth B Haagsma
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, The Netherlands
    Liver Transpl 14:547-53. 2008
    b>Hepatitis E virus (HEV) infection is known to run a self-limiting course. Sporadic cases of acute hepatitis due to infection with HEV genotype 3, present in pig populations, are increasingly recognized...
  9. ncbi Hepatitis E virus antibodies in hemodialysis patients: an epidemiological survey in central Greece
    I Stefanidis
    University of Thessalia, School of Medicine, Larissa Greece
    Int J Artif Organs 27:842-7. 2004
    b>Hepatitis E virus (HEV) is the causative agent for enteric non-A, non-B hepatitis. Transmission is mainly via the fecal-oral route but the possibility of an additional parenteric transmission has been raised...
  10. ncbi Identification by phage display and characterization of two neutralizing chimpanzee monoclonal antibodies to the hepatitis E virus capsid protein
    D J Schofield
    Hepatitis Viruses, National Institutes of Health, Bethesda, Maryland 20852, USA
    J Virol 74:5548-55. 2000
    Two monoclonal antibodies (MAbs) against the ORF2 protein of the SAR-55 strain of hepatitis E virus (HEV) were isolated by phage display from a cDNA library of chimpanzee (Pan troglodytes) gamma1/kappa antibody genes...
  11. ncbi Development and characterization of a genotype 4 hepatitis E virus cell culture system using a HE-JF5/15F strain recovered from a fulminant hepatitis patient
    Toshinori Tanaka
    Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, 3311 1 Yakushiji, Shimotsuke shi, Tochigi Ken 329 0498, Japan
    J Clin Microbiol 47:1906-10. 2009
    We developed an efficient cell culture system for genotype 4 hepatitis E virus using the HE-JF5/15F strain recovered from a fulminant hepatitis patient. The sixth-passage virus in the culture supernatant reached 1...
  12. ncbi Hepatitis E virus-related cirrhosis in kidney- and kidney-pancreas-transplant recipients
    N Kamar
    Department of Nephrology, Dialysis and Multi Organ Transplantation, and INSERM U858, IFR 31, CHU Rangueil, Toulouse, France
    Am J Transplant 8:1744-8. 2008
    b>Hepatitis E virus (HEV) infection was thought to be responsible for acute hepatitis that did not become chronic...
  13. ncbi Seroepidemiology and genetic characterization of hepatitis E virus in the northeast of China
    Yuanhua Yu
    School of Life Science and Technology, Changchun University of Science and Technology, Changchun, PR China
    Infect Genet Evol 9:554-61. 2009
    The aim of this study was to analyze the prevalence of infection and genotype of hepatitis E virus (HEV) in people and animals in the northeast of China (Heilongjiang, Jilin and Liaoning provinces)...
  14. ncbi A review of hepatitis E virus
    J L Smith
    US Department of Agriculture, Agricultural Research Service, Eastern Regional Research Center, Wyndmoor, Pennsylvania 19038, USA
    J Food Prot 64:572-86. 2001
    b>Hepatitis E virus (HEV) is a major cause of outbreaks and sporadic cases of viral hepatitis in tropical and subtropical countries but is infrequent in industrialized countries...
  15. ncbi Hepatitis E virus in Isfahan Province: a population-based study
    Behrooz Ataei
    Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
    Int J Infect Dis 13:67-71. 2009
    b>Hepatitis E virus (HEV) is an enterically transmitted acute viral hepatitis with the highest incidence in Asia, Africa, the Middle East, and Central America. There are few published data on the epidemiology of the infection in Iran...
  16. ncbi Identification of swine hepatitis E virus (HEV) and prevalence of anti-HEV antibodies in swine and human populations in Korea
    In-Soo Choi
    Department of Infectious Diseases, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Seoul 151-742, Korea
    J Clin Microbiol 41:3602-8. 2003
    The swine hepatitis E virus (HEV) is considered to be a new zoonotic agent due to its close genomic resemblance to the human HEV and its ability to infect nonhuman primates...
  17. ncbi Autochthonous hepatitis E in Southwest England: natural history, complications and seasonal variation, and hepatitis E virus IgG seroprevalence in blood donors, the elderly and patients with chronic liver disease
    Harry R Dalton
    Cornwall Gastrointestinal Unit, Royal Cornwall Hospital Trust, Truro, Cornwall, UK
    Eur J Gastroenterol Hepatol 20:784-90. 2008
    To report the natural history of autochthonous hepatitis E and hepatitis E virus (HEV) IgG seroprevalence in Southwest England.
  18. ncbi In vitro replication of hepatitis E virus (HEV) genomes and of an HEV replicon expressing green fluorescent protein
    Suzanne U Emerson
    Laboratory of Infectious Diseases and Flow Cytometry Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 8009, USA
    J Virol 78:4838-46. 2004
    b>Hepatitis E virus (HEV) RNA replication occurred in seven of nine primate cell cultures transfected with in vitro transcripts of an infectious cDNA clone...
  19. ncbi Hepatitis E virus infection and fulminant hepatic failure during pregnancy
    Nishat Jilani
    Department of Medicine, Maulana Azad Medical College and Associated Lok Nayak Hospital, Jamia Millia Islamia, New Delhi, India
    J Gastroenterol Hepatol 22:676-82. 2007
    b>Hepatitis E virus (HEV) infection leading to fulminant hepatic failure (FHF) and high mortality is a common feature in Indian women during the second and third trimesters of pregnancy...
  20. ncbi Structure of hepatitis E virion-sized particle reveals an RNA-dependent viral assembly pathway
    Li Xing
    Department of Molecular and Cellular Biology, University of California, Davis, California 95616, USA
    J Biol Chem 285:33175-83. 2010
    b>Hepatitis E virus (HEV) induces acute hepatitis in humans with a high fatality rate in pregnant women. There is a need for anti-HEV research to understand the assembly process of HEV native capsid...
  21. ncbi Unexpected high prevalence of IgG-antibodies to hepatitis E virus in Swedish pig farmers and controls
    Bjorn Olsen
    Department of Infectious Diseases, Umea University, and Department of Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Scand J Infect Dis 38:55-8. 2006
    b>Hepatitis E virus (HEV) infections are responsible for large waterborne outbreaks in developing countries. Sporadic cases in the developed world are mainly imported via immigrants and travellers from endemic areas...
  22. ncbi Cross-species infections of cultured cells by hepatitis E virus and discovery of an infectious virus-host recombinant
    Priyanka Shukla
    Section of Molecular Hepatitis, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:2438-43. 2011
    The RNA virus, hepatitis E virus (HEV) is the most or second-most important cause of acute clinical hepatitis in adults throughout much of Asia, the Middle East, and Africa...
  23. ncbi Time trend of the prevalence of hepatitis E antibodies among farmers and blood donors: a potential zoonosis in Denmark
    Peer B Christensen
    Department of Infectious Diseases, Odense University Hospital, Denmark
    Clin Infect Dis 47:1026-31. 2008
    Antibody to hepatitis E virus (anti-HEV) is prevalent in Western countries, where clinical hepatitis E is rarely reported. The aim of this study was to determine the prevalence of anti-HEV among Danish blood donors and Danish farmers...
  24. ncbi Detection by reverse transcription-PCR and genetic characterization of field isolates of swine hepatitis E virus from pigs in different geographic regions of the United States
    F F Huang
    Center for Molecular Medicine and Infectious Diseases, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061-0342, USA
    J Clin Microbiol 40:1326-32. 2002
    b>Hepatitis E virus (HEV) is an important public health concern in many developing countries. HEV is also endemic in some industrialized counties, including the United States...
  25. ncbi Hepatitis E virus: molecular virology, clinical features, diagnosis, transmission, epidemiology, and prevention
    Isa K Mushahwar
    Infectious Disease Diagnostics, Tierra Verde, Florida 33715, USA
    J Med Virol 80:646-58. 2008
    b>Hepatitis E virus (HEV), the sole member of the genus Hepevirus in the family of Hepeviridae, is the major cause of several outbreaks of waterborne hepatitis in tropical and subtropical countries and of sporadic cases of viral hepatitis ..
  26. ncbi Swine hepatitis E virus: cross-species infection and risk in xenotransplantation
    X J Meng
    Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, 1410 Price s Fork Road, Blacksburg, VA 24061 0342, USA
    Curr Top Microbiol Immunol 278:185-216. 2003
    Swine hepatitis E Virus (swine HEV), a ubiquitous agent recently discovered in pigs, is antigenically and genetically closely related to the human HEV...
  27. ncbi Hepatitis E virus epidemiology in industrialized countries
    Pilar Clemente-Casares
    University of Barcelona, Barcelona, Spain
    Emerg Infect Dis 9:448-54. 2003
    To determine the prevalence of Hepatitis E virus (HEV) in industrialized nations, we analyzed the excretion of HEV strains by the populations of Spain, France, Greece, Sweden, and the United States. Twenty of 46 (43...
  28. ncbi Sources of hepatitis E virus genotype 3 in The Netherlands
    Saskia A Rutjes
    Laboratory for Zoonoses and Environmental Microbiology, Centre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Emerg Infect Dis 15:381-7. 2009
    Non-travel-related hepatitis E virus (HEV) genotype 3 infections in persons in the Netherlands may have a zoonotic, foodborne, or water-borne origin. Possible reservoirs for HEV transmission by water, food, and animals were studied...
  29. ncbi Hepatitis E, Central African Republic
    Josep M Escribà
    Emerg Infect Dis 14:681-3. 2008
  30. ncbi Prevalence and genotyping of hepatitis E virus in swine population in Korea between 1995 and 2004: a retrospective study
    K Jung
    Department of Veterinary Pathology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Kwanak Gu 151 742, Seoul, Republic of Korea
    Vet J 173:683-7. 2007
    b>Hepatitis E virus (HEV) infections have been reported in pigs throughout the world but have only recently been recorded in Korean pigs...
  31. ncbi Mutational events during the primary propagation and consecutive passages of hepatitis E virus strain JE03-1760F in cell culture
    Felipe R Lorenzo
    Department of Infection and Immunity, Division of Virology, Jichi Medical University School of Medicine, Shimotsuke shi, Tochigi ken, Japan
    Virus Res 137:86-96. 2008
    We recently developed a cell culture system for hepatitis E virus (HEV) in PLC/PRF/5 cells, using a genotype 3 HEV (JE03-1760F strain)...
  32. ncbi Identification of genetic diversity of hepatitis E virus (HEV) and determination of the seroprevalence of HEV in eastern China
    C Dong
    Department of Microbiology and Immunology, School of Medicine, Southeast University, Nanjing, China
    Arch Virol 152:739-46. 2007
    b>Hepatitis E, caused by the hepatitis E virus (HEV), is endemic in China. However, the molecular characteristics of HEV circulating in eastern China and the seroprevalence of HEV infection in eastern China are relatively unknown...
  33. ncbi Locally acquired hepatitis E in chronic liver disease
    H R Dalton
    Lancet 369:1260. 2007
  34. ncbi Intrafamilial hepatitis E in France
    A Ducancelle
    , CHU Angers, Paris
    J Clin Virol 39:51-3. 2007
  35. ncbi Seroepidemiology of hepatitis E virus infection in 2-25-year-olds in Sari district, Islamic Republic of Iran
    M J Saffar
    Department of Paediatrics, Mazandaran University of Medical Sciences, Sari, Islamic Republic of Iran
    East Mediterr Health J 15:136-42. 2009
    The seroprevalence of hepatitis E virus infection (HEV) in children and young adults was determined in a community-based survey in an area of northern Islamic Republic of Iran...
  36. ncbi Hepatitis E and meat carcasses
    Chris Jary
    Br J Gen Pract 55:557-8. 2005
  37. ncbi Neuralgic amyotrophy associated with hepatitis E virus
    Farina Fong
    Clin Neurol Neurosurg 111:193-5. 2009
    ..Serology was positive for hepatitis E infection and negative for other infections previously described to be associated with NA...
  38. ncbi Construction and characterization of infectious cDNA clones of a chicken strain of hepatitis E virus (HEV), avian HEV
    F F Huang
    Center for Molecular Medicine and Infectious Diseases, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, 1410 Price's Fork Road, Blacksburg, VA 24061-0342, USA
    J Gen Virol 86:2585-93. 2005
    b>Hepatitis E virus (HEV), the causative agent of hepatitis E, is an important human pathogen. Increasing evidence indicates that hepatitis E is a zoonosis...
  39. ncbi Frequency and clinical course of hepatitis E in tertiary care hospitals
    Mohammad Ilyas Saeedi
    Department of Medicine, Medical C Unit, PGMI/Lady Reading Hospital, Peshawar
    J Coll Physicians Surg Pak 14:527-9. 2004
    OBJECTIVE: To find out the frequency of hepatitis E virus as a cause of acute hepatitis and its clinical course in hospitalized patients. DESIGN: Cross-sectional hospital-based study...
  40. ncbi Guillain-Barre syndrome associated with acute hepatitis E
    Praful Kamani
    Gastroenterology Center, Jagjivanram Hospital, Mumbai
    Indian J Gastroenterol 24:216. 2005
    ..She was diagnosed to be suffering from Guillain-Barre syndrome and acute hepatitis E. Such an association has not been described till date.
  41. ncbi Phylogenetic and case-control study on hepatitis E virus infection in Germany
    Ole Wichmann
    Department of Infectious Disease Epidemiology, Robert Koch Institute, Germany
    J Infect Dis 198:1732-41. 2008
    b>Hepatitis E is a classic water-borne disease in developing countries. In Germany, hepatitis E virus (HEV) infections are notifiable...
  42. ncbi Guillain-Barré syndrome following hepatitis E
    Jean Philippe Loly
    Department of Hepato Gastroenterology, CHU Sart Tilman, Universite de Liege, Liege, Belgium
    World J Gastroenterol 15:1645-7. 2009
    ..A, B and C, and three cases have been previously described in India in which GBS was associated with acute hepatitis E. A molecular mimicry mechanism is supposed to be involved in the pathogenesis of GBS triggered by infectious ..
  43. ncbi Epidemiology of hepatitis E in Northeastern China, South Korea and Japan
    Miyuki Taniguchi
    Department of Gastroenterology, Kobe Asahi Hospital, Nagata ku, Kobe, Japan
    J Infect 58:232-7. 2009
    The seroprevalence of hepatitis E virus (HEV) infection in Northeastern Asia is unknown. This study was conducted to gain insight into the epidemiology of HEV that has been obscure in Northeastern China, South Korea and Japan.
  44. ncbi Acute transverse myelitis following hepatitis E virus infection
    Kausik Mandal
    Indian Pediatr 43:365-6. 2006
  45. ncbi [A case of acute hepatitis E with the travel history to an endemic area]
    Soon Sub Kim
    Department of Internal Medicine and WHO Collaborating Center on Viral Hepatitis, The Catholic University of Korea College of Medicine, Seoul 137-040, Korea
    Korean J Gastroenterol 44:342-5. 2004
    b>Hepatitis E is a self-limited and enterically transmitted acute viral hepatitis that occurs from epidemic outbreaks of developing countries and sporadic hepatitis in non-endemic areas...
  46. ncbi Release of genotype 1 hepatitis E virus from cultured hepatoma and polarized intestinal cells depends on open reading frame 3 protein and requires an intact PXXP motif
    Suzanne U Emerson
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, MSC 8009, Bethesda, MD 20892, USA
    J Virol 84:9059-69. 2010
    b>Hepatitis E virus genotype 1 strain Sar55 replicated in subcloned Caco-2 intestinal cells and Huh7 hepatoma cells that had been transfected with in vitro transcribed viral genomes, and hepatitis E virions were released into the culture ..
  47. ncbi Structural characterization of recombinant hepatitis E virus ORF2 proteins in baculovirus-infected insect cells
    R A Robinson
    Molecular Virology Laboratory, DynCorp, 1 Taft Court, Rockville, Maryland 20850, USA
    Protein Expr Purif 12:75-84. 1998
    The hepatitis E virus (HEV) capsid antigen has been proposed as a candidate subunit vaccine for the prevention of hepatitis E. The full-length HEV ORF2 protein product is predicted to contain 660 amino acids and to weigh 72,000 daltons...
  48. ncbi Detection of swine hepatitis E virus in the porcine hepatic lesion in Jeju Island
    Song Hak Lee
    Department of Veterinary Medicine, Cheju National University, Jeju 690 756, Korea
    J Vet Sci 8:51-5. 2007
    Swine hepatitis E virus (HEV) is an emerging zoonotic pathogen due to its close genomic similarity to human HEV...
  49. ncbi Characterization of hepatitis E-specific cell-mediated immune response using IFN-gamma ELISPOT assay
    M T Shata
    Internal Medicine, Division of Digestive Diseases, University of Cincinnati, Cincinnati, OH 45267 0595, USA
    J Immunol Methods 328:152-61. 2007
    In developing countries, hepatitis E (HEV) and hepatitis A (HAV) are the major causes of acute viral hepatitis with similar feco-oral modes of transmission...
  50. ncbi Prevalence of Hepatitis E virus-specific antibodies in sera of German domestic pigs estimated by using different assays
    Christine Baechlein
    Department of Infectious Diseases, Institute of Virology, University of Veterinary Medicine Hannover, Buenteweg 17, 30559 Hannover, Germany
    Vet Microbiol 144:187-91. 2010
    b>Hepatitis E virus is the causative agent of an acute hepatitis in humans...
  51. ncbi The entire genome sequence of hepatitis E virus genotype 3 isolated from a patient with neuralgic amyotrophy
    Pornpimol Rianthavorn
    Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University and Hospital, Bangkok, Thailand
    Scand J Infect Dis 42:395-400. 2010
    ..with acute and severe pain in the upper extremities, followed by patchy muscle weakness, associated with hepatitis E virus (HEV) infection...
  52. ncbi Characterization of a prototype strain of hepatitis E virus
    S A Tsarev
    Hepatitis Viruses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 89:559-63. 1992
    A strain of hepatitis E virus (SAR-55) implicated in an epidemic of enterically transmitted non-A, non-B hepatitis, now called hepatitis E, was characterized extensively...
  53. ncbi Hepatitis E virus: a zoonosis adapting to humans
    Florian Bihl
    Department of Gastroenterology and Hepatology, University Hospital Geneva, Geneva, Switzerland
    J Antimicrob Chemother 65:817-21. 2010
    b>Hepatitis E virus (HEV) infection is gaining global attention, not only because of the increasing burden of the disease in low endemicity countries, in terms of morbidity and mortality rates, but also due to recent advances in the ..
  54. ncbi Detection rates of the swine torque teno viruses (TTVs), porcine circovirus type 2 (PCV2) and hepatitis E virus (HEV) in the livers of pigs with hepatitis
    Bozidar Savic
    Department for Swine Diseases, Institute of Veterinary Medicine Belgrade, Serbia, V Toze 14, 11 000, Belgrade, Serbia
    Vet Res Commun 34:641-8. 2010
    Porcine circovirus type 2 (PCV2) and hepatitis E virus (HEV) are the most recently recognized causes of infectious hepatitis of pigs and may or may not act independently in the development of the disease...
  55. ncbi Cell culture of sporadic hepatitis E virus in China
    R Huang
    Beijing Institute of Microbiology and Epidemiology, Beijing 100850, China
    Clin Diagn Lab Immunol 6:729-33. 1999
    The isolation and identification of the 87A strain of epidemic hepatitis E virus (HEV) by means of cell culturing have been described previously...
  56. ncbi Hepatitis E virus infection: a general review with a focus on hemodialysis and kidney transplant patients
    Seyed Mohammadmehdi Hosseini-Moghaddam
    Infectious Diseases and Tropical Medicine, Urology and Nephrology Research Center, Shahid Beheshti University, Tehran, Islamic Republic of Iran h_sasan hotmail com
    Am J Nephrol 31:398-407. 2010
    b>Hepatitis E virus (HEV) infection is a self-limited viral disease that causes acute hepatitis epidemics in developing countries. The common route of transmission for HEV is supposedly fecal-oral...
  57. ncbi Determination of the 5'-terminal sequence of subgenomic RNA of hepatitis E virus strains in cultured cells
    Koji Ichiyama
    Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan
    Arch Virol 154:1945-51. 2009
    Using RNA preparations extracted from PLC/PRF/5 cells transfected with infectious genotype 3 hepatitis E virus (HEV) cDNA clones or inoculated with a fecal suspension containing a genotype 4 HEV, the 5'-terminal sequence of a 2...
  58. ncbi Hepatitis E virus infection as a cause of graft hepatitis in liver transplant recipients
    Sven Pischke
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    Liver Transpl 16:74-82. 2010
    b>Hepatitis E virus (HEV) infection induces self-limiting liver disease in immunocompetent individuals. Cases of chronic hepatitis E have recently been identified in organ transplant recipients...
  59. ncbi Effect of acute hepatitis E infection in patients with liver cirrhosis
    S KC
    Liver Unit Bir Hospital, National Academy of Medical Sciences, Kathmandu, Nepal
    JNMA J Nepal Med Assoc 48:226-9. 2009
    b>Hepatitis E virus is a major cause of enterically transmitted hepatitis. Mortality is very high if it is associated with pregnancy, especially during third trimester...
  60. ncbi Seroepidemiology and molecular characterization of hepatitis E virus in Jilin, China
    G Zhu
    Genetic Engineering Laboratory, Academy of Military Medical Sciences, 1068 Qinglong Road, Changchun, 130062, People s Republic of China
    Infection 36:140-6. 2008
    In order to develop region-specific diagnostic assays and prevent hepatitis E virus (HEV), it is essential to understand epidemiology and genotypic variation within different populations...
  61. ncbi [Liver cirrhosis due to hepatitis E in a kidney transplant patient]
    Yolanda Verhoeven
    Ziekenhuis Gelderse Vallei, afd Interne Geneeskunde, Ede, The Netherlands
    Ned Tijdschr Geneeskd 154:A1790. 2010
    Until recently, hepatitis E was considered to be an infectious disease that resolved without any long-term complications...
  62. ncbi Prevalence of hepatitis E virus infection in liver transplant recipients
    Elizabeth B Haagsma
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Liver Transpl 15:1225-8. 2009
    b>Hepatitis E virus (HEV) infection is known to run a self-limited course. Recently, chronic hepatitis E has been described in several immunosuppressed patients after solid organ transplantation...
  63. ncbi Epidemiology and genotypes of HEV in Wuhan
    Yan Chen
    Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Chin J Dig Dis 6:182-8. 2005
    BACKGROUND: Understanding the genotype and clinical features of the hepatitis E virus (HEV) are important for understanding its characteristics, for evaluating region-specific diagnostic assays, and producing vaccines...
  64. ncbi Cross-species infection of specific-pathogen-free pigs by a genotype 4 strain of human hepatitis E virus
    A R Feagins
    Department of Biomedical Sciences and Pathobiology, Center for Molecular Medicine and Infectious Diseases, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0342, USA
    J Med Virol 80:1379-86. 2008
    b>Hepatitis E virus (HEV) is an important pathogen. The animal strain of HEV, swine HEV, is related to human HEV. The genotype 3 swine HEV can infect humans and genotype 3 human HEV can infect pigs...
  65. ncbi Identification of novel human hepatitis E virus (HEV) isolates and determination of the seroprevalence of HEV in Korea
    Jeong-Min Ahn
    Department of Infectious Disease, College of Veterinary Medicine, Seoul National University, Shinlim-Dong, Kwanak-Gu, Seoul 151-742, Korea
    J Clin Microbiol 43:3042-8. 2005
    b>Hepatitis E virus (HEV) was originally identified as the causative agent of enterically transmitted non-A, non-B hepatitis. Recently, HEV isolates were subsequently identified in humans and swine in many countries, including Korea...
  66. ncbi Significance of serum IgA in patients with acute hepatitis E virus infection
    De Ying Tian
    Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Provice, China
    World J Gastroenterol 12:3919-23. 2006
    To study the significance of serum anti-hepatitis E virus (HEV) IgA in patients with hepatitis E.
  67. ncbi Cross-protection of hepatitis E virus genotypes 1 and 4 in rhesus macaques
    Weijin Huang
    Department of Cell Biology, National Institute for the Control of Pharmaceutical and Biological Products, Beijing, China
    J Med Virol 80:824-32. 2008
    ..In conclusion, previous HEV infection may give rise to cross-genotype and cross-host-species protection...
  68. ncbi Serological evidence of hepatitis E virus infection in different animal species from the Southeast of Brazil
    Claudia L Vitral
    Departamento de Virologia, Instituto Oswaldo Cruz FIOCRUZ, Av Brasil 4365, 21040 900 Rio de Janeiro, RJ, Brasil
    Mem Inst Oswaldo Cruz 100:117-22. 2005
    Serological evidence of hepatitis E virus infection (HEV) has been observed in both humans and different animal species living in non-endemic areas, suggesting that animals could be important reservoir for virus transmission to man...
  69. ncbi Double-antigen enzyme-linked immunosorbent assay for detection of hepatitis E virus-specific antibodies in human or swine sera
    Wei Ping Hu
    MP Biomedicals Asia Pacific Pte Ltd, Singapore, Republic of Singapore
    Clin Vaccine Immunol 15:1151-7. 2008
    ..immunosorbent assay (ELISA) for the detection of total antibodies (immunoglobulin G [IgG] and IgM) specific for hepatitis E virus (HEV) was developed by utilizing well-characterized recombinant protein ET2...
  70. ncbi [Viral hepatitis E. The problems of its study]
    M I Mikhailov
    Vopr Virusol 50:20-2. 2005
    The paper presents the results of investigations of hepatitis E (HE), which have been made at the Department of Viral Hepatitides, M. P. Chumakov Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences. M...
  71. ncbi Age-specific antibody to hepatitis E virus has remained constant during the past 20 years in Japan
    E Tanaka
    Department of Medicine, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    J Viral Hepat 12:439-42. 2005
    We investigated the presence of antibodies to hepatitis E virus (anti-HEV) and hepatitis A virus (anti-HAV) by enzyme immunoassays in sera from 1015 individuals collected in 1974, 1984 and 1994...
  72. ncbi Investigation of hepatitis E virus infection in swine from Hunan province, China
    Xiuji Li
    Department of Cell Biology, National Institute for the Control of Pharmaceutical and Biological Products, Beijing, PR China
    J Med Virol 80:1391-6. 2008
    ..and four serum samples were collected from pigs from 16 pig farms in China's Hunan province and tested for anti-hepatitis E virus (HEV) antibody and the HEV capsid antigen using EIAs. Of the 904 samples, 617 (68.3%) and 57 (6...
  73. ncbi Epidemiology and clinical features of sporadic hepatitis E as compared with hepatitis A
    Tai Nin Chau
    Department of Medicine and Geriatrics, United Christian Hospital, Hong Kong SAR, China
    Am J Gastroenterol 101:292-6. 2006
    OBJECTIVES: To compare the epidemiology and clinical features of two enterically transmitted hepatitis, namely hepatitis E and hepatitis A...
  74. ncbi Acute polyarthritis revealing hepatitis E
    Jacques Serratrice
    Service de Medecine Interne, CHU Timone, 264 rue Saint Pierre, 13385, Marseille Cedex 5, France
    Clin Rheumatol 26:1973-5. 2007
    We report a case of acute hepatitis E occurring in a 51-year-old French woman, revealed by an abrupt onset of polyarthritis involving the ankles and knees followed by the wrists and fingers...
  75. ncbi Ongoing subclinical infection of hepatitis E virus among blood donors with an elevated alanine aminotransferase level in Japan
    Yuhko Gotanda
    Japanese Red Cross Saitama Blood Center, Saitama Ken, Japan
    J Med Virol 79:734-42. 2007
    Ongoing subclinical infection of hepatitis E virus (HEV) has not been fully studied...
  76. ncbi Hepatitis E virus infection among domestic animals in eastern China
    W Zhang
    Shanghai Key Laboratory of Veterinary Medicine, School of Agriculture and Biology, Shanghai Jiaotong University, 800 Dongchuan Road, Shanghai, China
    Zoonoses Public Health 55:291-8. 2008
    b>Hepatitis E virus (HEV) is a zoonotic pathogen of which several species of animal were reported as reservoirs. Antibodies to HEV and HEV RNA have been detected in some Chinese population and swine groups but few other domestic animals...
  77. ncbi Presence of hepatitis E virus in a naturally infected swine herd from nursery to slaughter
    Danielle Leblanc
    Agriculture and Agri Food Canada, Food Research and Development Centre, 3600 Casavant Blvd West, Saint Hyacinthe, Quebec, Canada J2S 8E3
    Int J Food Microbiol 117:160-6. 2007
    b>Hepatitis E virus has recently been recognized as having zoonotic potential and could be transmitted from pig to human...
  78. ncbi Identification of the first strain of swine hepatitis E virus in South America and prevalence of anti-HEV antibodies in swine in Argentina
    María S Munné
    Nacional Reference Lab for Viral Hepatitis, National Institute of Infectious Diseases, ANLIS Dr C G Malbran, Buenos Aires, Argentina
    J Med Virol 78:1579-83. 2006
    In Argentina, a country considered non-endemic for hepatitis E virus (HEV) infection, serologic evidence of HEV infection has been observed in different human population groups...
  79. ncbi Hepatitis E virus infection among animals in northern India: an unlikely source of human disease
    P Shukla
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Viral Hepat 14:310-7. 2007
    b>Hepatitis E virus (HEV) is a major cause of acute hepatitis in many developing countries. Based on data from nonendemic regions, an animal reservoir of HEV has been proposed; however, data from HEV-endemic regions are limited...
  80. ncbi Prevalence of hepatitis E virus antibodies in pigs: implications for human infections in village-based subsistence pig farming in the Lao PDR
    Stuart D Blacksell
    Wellcome Trust Mahosot Hospital Oxford University Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Lao PDR
    Trans R Soc Trop Med Hyg 101:305-7. 2007
    We report a high seroprevalence of hepatitis E virus (HEV) in pigs in the Lao PDR. HEV seroprevalence was 51.2% (300/586) amongst abattoir pigs and 15.3% (46/301) amongst village pigs...
  81. ncbi Evaluation of human (genotype 1) and swine (genotype 4)-ORF2-based ELISAs for anti-HEV IgM and IgG detection in an endemic country and search for type 4 human HEV infections
    V A Arankalle
    Hepatitis Division, National Institute of Virology, Pune, India
    J Viral Hepat 14:435-45. 2007
    Open reading frame 2 proteins (ORF2) from swine (genotype 4, S-ORF2) and human (genotype 1, H-ORF2) hepatitis E virus (HEV) having 91.4% identity at amino acid level were expressed using baculovirus expression system...
  82. ncbi Seroepidemiology of hepatitis E virus in patients with non-A, non-B, non-C hepatitis in Hungary
    Annika Haagsman
    Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    J Med Virol 79:927-30. 2007
    Many cases of acute hepatitis remain undiagnosed and the hepatitis E virus (HEV) is emerging in industrialized countries...
  83. ncbi Bayesian estimation of hepatitis E virus seroprevalence for populations with different exposure levels to swine in The Netherlands
    M Bouwknegt
    Laboratory for Zoonoses and Environmental Microbiology, Centre for Infectious Disease Control Netherlands, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Epidemiol Infect 136:567-76. 2008
    b>Hepatitis E virus (HEV) is ubiquitous in pigs worldwide and may be zoonotic. Previous HEV seroprevalence estimates for groups of people working with swine were higher than for control groups...
  84. ncbi Changing patterns of hepatitis A and E sero-prevalences in children after the 1999 earthquakes in Duzce, Turkey
    Ayse Demet Kaya
    Department of Microbiology, Medical Faculty, Duzce University, Konuralp, Duzce, Turkey
    J Paediatr Child Health 44:205-7. 2008
    ..Sero-epidemiological data about both infections showed higher prevalence rates soon after the 1999 earthquakes in Duzce, Turkey. The aim of the present study was to evaluate the data 4 years after the earthquakes...
  85. ncbi Serological response to hepatitis E virus genotype 3 infection: IgG quantitation, avidity, and IgM response
    R Bendall
    Department of Clinical Microbiology, Royal Cornwall Hospital Trust, Truro, Cornwall, UK
    J Med Virol 80:95-101. 2008
    Sequential sera were collected from 18 acute cases of UK-acquired hepatitis E. The virus strains in all cases were of genotype 3...
  86. ncbi [Hepatitis A and E virus antibodies in Chilean children of low socioeconomic status: a one year follow-up study]
    Humberto Ibarra
    Instituto de Microbiologia, Instituto de Medicina, Universidad Austral de Chile, Valdivia, Chile
    Rev Med Chil 134:139-44. 2006
    ..However, there is no information available about low socioeconomic status (LSE) populations...
  87. ncbi Autochthonous hepatitis E in southwest England
    H R Dalton
    Cornwall Gastrointestinal Unit, Royal Cornwall Hospital Trust, Truro, UK
    J Viral Hepat 14:304-9. 2007
    Although autochthonous hepatitis E has been reported in developed countries, its extent and nature in the United Kingdom are unclear...
  88. ncbi Correlation between positivity for immunoglobulin A antibodies and viraemia of swine hepatitis E virus observed among farm pigs in Japan
    Masaharu Takahashi
    Division of Virology, Department of Infection and Immunity, Jichi Medical School, Tochigi-Ken 329-0498, Japan
    J Gen Virol 86:1807-13. 2005
    To evaluate the usefulness of detection of antibodies to hepatitis E virus (HEV) to screen for viraemic pigs, serum samples obtained from 1425 1-6-month-old pigs in Japan were tested for swine HEV RNA and IgG, IgM and IgA classes of anti-..
  89. ncbi [Detection of anti-HAV IgM and anti-HEV IgM in patients with sporadic acute hepatitis in Beijing between 1995-2000]
    J Lu
    Institute of Virology, Chinese Academy of Preventive Medicine, Beijing 100052, China
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 15:157-9. 2001
    ..The patients with acute hepatitis A and hepatitis E all experienced jaundice, a rising of liver enzyme, but not developed to chronic hepatitis or to death...
  90. ncbi Molecular and serological characterization of sporadic acute hepatitis E in a Japanese patient infected with a genotype III hepatitis E virus in 1993
    Hajime Tokita
    Department of Gastroenterology, National Tokyo Hospital, Kiyose, Japan
    J Gen Virol 84:421-7. 2003
    ..from a 40-year-old Japanese woman who had not travelled abroad and who had contracted sporadic acute hepatitis E in 1993 were semi-quantitatively tested by enzyme immunoassay for IgM, IgA and IgG antibodies to hepatitis E ..
  91. ncbi Seroprevalence of antibodies to hepatitis A and E viruses in pediatric age groups in Turkey
    D Colak
    Department of Clinical Microbiology, Akdeniz University Medical School, Antalya, Turkey
    Acta Microbiol Immunol Hung 49:93-7. 2002
    Hepatitis A and hepatitis E are enteric transmitted viral diseases occurring in epidemic and sporadic forms especially in developing countries...
  92. ncbi Swine HEV infection in south India and phylogenetic analysis (1985-1999)
    V A Arankalle
    Hepatitis Division, National Institute of Virology, Pune, India
    J Med Virol 69:391-6. 2003
    b>Hepatitis E is endemic in India. It was recently noted that although all the Indian human hepatitis E virus (HEV) isolates (1976-2001) were placed in genotype I, the swine HEV recovered from western India (2000) belonged to genotype IV...
  93. ncbi [Hepatitis A and hepatitis E seroprevalence in adults in the Ankara area]
    Salih Cesur
    , Klinik Bakteriyoloji ve Infeksiyon Hastaliklari Anabilim Dali, Ankara
    Mikrobiyol Bul 36:79-83. 2002
    In this study, between the period of September 2000 to July 2001, hepatitis A virus (HAV) IgG antibodies and hepatitis E virus (HEV) total (IgG + IgM) antibodies have been searched by using commercially provided enzyme immunoassay kits (..
  94. ncbi Evidence that rodents are a reservoir of hepatitis E virus for humans in Nepal
    Junkun He
    Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
    J Clin Microbiol 40:4493-8. 2002
    b>Hepatitis E virus (HEV) is an important cause of enterically transmitted hepatitis in developing countries. Sporadic autochthonous cases of hepatitis E have been reported recently in the United States and other industrialized countries...
  95. ncbi Hepatitis e virus infection in fulminant hepatitis patients and an apparently healthy population in Bangladesh
    Aleemuzzaman Sheikh
    Department of Pathology, Nihon University School of Medicine, Tokyo, Japan
    Am J Trop Med Hyg 66:721-4. 2002
    This is the first study comparing hepatitis E virus (HEV) infection in Bangladesh in fulminant hepatitis (FH) patients presumed to have a viral cause and in the apparently healthy population...
  96. ncbi Clinical and epidemiological relevance of quantitating hepatitis E virus-specific immunoglobulin M
    Jitvimol Seriwatana
    Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    Clin Diagn Lab Immunol 9:1072-8. 2002
    Diagnosis of acute hepatitis E by detection of hepatitis E virus (HEV)-specific immunoglobulin M (IgM) is an established procedure...
  97. ncbi Polyphyletic strains of hepatitis E virus are responsible for sporadic cases of acute hepatitis in Japan
    Hitoshi Mizuo
    Department of Internal Medicine, Kin-ikyo Chuo Hospital, Hokkaido 007-0870, Japan
    J Clin Microbiol 40:3209-18. 2002
    ..and 2001 at five hospitals in Japan, 11 (13%) patients were positive for immunoglobulin M-class antibodies to hepatitis E virus (HEV) by enzyme immunoassay and had detectable HEV RNA by reverse transcription-PCR with two independent ..
  98. ncbi Antibody levels to hepatitis E virus in North Carolina swine workers, non-swine workers, swine, and murids
    Mark R Withers
    Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    Am J Trop Med Hyg 66:384-8. 2002
    ..Carolina swine workers (n = 165) were compared with non-swine workers (127) for the presence of antibodies to hepatitis E virus as measured by a quantitative immunoglobulin enzyme-linked immunosorbent assay...
  99. ncbi Prevalence, isolation, and partial sequence analysis of hepatitis E virus from domestic animals in China
    You-Chun Wang
    National Institute for the Control of Pharmaceuticals and Biological Products, Beijing, People's Republic of China
    J Med Virol 67:516-21. 2002
    Evidence that hepatitis E is zoonotic is accumulating. Serum samples were collected from pigs, cattle, and goats from various regions of China to determine whether they had been infected with hepatitis E virus (HEV)...
  100. ncbi [Propagation of hepatitis E virus in an endemic and nonendemic regions]
    S N Kuzin
    Vopr Virusol 47:18-21. 2002
    The role of hepatitis E (HE) in sporadic morbidity at an endemic territory (Southern Uzbekistan) and the incidence of anti-HEV in different populations of a nonendemic region (Russia) were evaluated. Antibodies to HEV were detected in 22...
  101. ncbi Human and swine hepatitis E viruses from Western India belong to different genotypes
    Vidya A Arankalle
    Hepatitis Division, National Institute of Virology, 20 A, Dr Ambedkar Road, 411001, Pune, India
    J Hepatol 36:417-25. 2002
    b>Hepatitis E is endemic in India. Earlier, we showed prevalence of IgG antibodies to hepatitis E virus (IgG-anti-HEV) in different animal species and inability of at least one human hepatitis E virus (HEV) strain to infect pigs...

Research Grants61

  1. Prevalence and Epidemiology of Hepatitis E Virus in the United States
    Kenrad Nelson; Fiscal Year: 2007
    b>Hepatitis E virus (HEV) is the etiologic agent responsible for large outbreaks of clinical hepatitis in developing countries and a large proportion of sporadic clinical hepatitis in developing countries...
  2. DETERMINANTS OF HEPATITIS C & E MORBIDITY IN EGYPT
    George Strickland; Fiscal Year: 2004
    ..been categorized into those infected with hepatitis C virus (HCV), a parenterally transmitted flavivirus, and hepatitis E virus (HEV), a fecal-oral transmitted "hepatitis E-like virus...
  3. MOLECULAR BIOLOGY OF RUBELLA VIRUS
    TERYL FREY; Fiscal Year: 2006
    ..pathogenesis and are of evolutionary interest in that, by computer alignment, they are more closely related to hepatitis E virus (HEV, an unclassified enteric virus) than to the alphaviruses, the other Togavirus genus...
  4. MOLECULAR BIOLOGY OF RUBELLA VIRUS
    TERYL FREY; Fiscal Year: 2000
    ..As part of this effort, the NSP open reading frame (ORF1) of hepatitis E virus (HEV) will be expressed to analyze its processing...
  5. CHARACTERIZATION OF HUMAN CALICIVIRUS
    Xi Jiang; Fiscal Year: 2001
    ..HuCVs include three genogroups: Norwalk virus (NV), Sapporo and Hepatitis E genogroups. The NV genogroup can be divided further into NV-like and Snow Mountain agent (SMA)-like HuCVs...
  6. Immune events, transcriptomics and biomarkers in hepatitis E pathogenesis
    Shahid Jameel; Fiscal Year: 2010
    b>Hepatitis E, caused by infection with waterborne hepatitis E virus (HEV) is endemic in several developing countries, particularly in Asia and Africa. In the Indian subcontinent, hepatitis E occurs as large outbreaks...
  7. Immune events, transcriptomics and biomarkers in hepatitis E pathogenesis
    Shahid Jameel; Fiscal Year: 2007
    b>Hepatitis E, caused by infection with waterborne hepatitis E virus (HEV) is endemic in several developing countries, particularly in Asia and Africa. In the Indian subcontinent, hepatitis E occurs as large outbreaks...
  8. Cell-free Replication of Hepatitis E Virus
    Naushad Ali; Fiscal Year: 2006
    b>Hepatitis E Virus (HEV) is a leading cause of severe acute hepatitis worldwide and numerous outbreaks in the developing countries...
  9. Longitudinal cohort of newly acquired HCV infection
    John Kaldor; Fiscal Year: 2007
    ..Drug use behavior including injecting drug use will also be closely monitored, to assess the impact of enrollment into the study and specific drug dependency and risk reduction strategies. ..
  10. Mechanism of Hepatitis E Virus Replication and Pathogenesis
    Xiang Jin Meng; Fiscal Year: 2009
    b>Hepatitis E virus (HEV), the causative agent of human hepatitis E, is an important public health problem in developing countries, and is also endemic in the United States and other industrialized countries...
  11. A Chicken Model to Study Hepatitis E Virus Pathogenesis
    Xiang Jin Meng; Fiscal Year: 2009
    b>Hepatitis E virus (HEV), the causative agent of human hepatitis E, is an important public health problem in many developing countries, and is also endemic in the United States and other industrialized countries...
  12. A Chicken Model to Study Hepatitis E Virus Pathogenesis
    Xiang Jin Meng; Fiscal Year: 2010
    b>Hepatitis E virus (HEV), the causative agent of human hepatitis E, is an important public health problem in many developing countries, and is also endemic in the United States and other industrialized countries...
  13. Mechanism of Hepatitis E Virus Replication and Pathogenesis
    Xiang Jin Meng; Fiscal Year: 2010
    b>Hepatitis E virus (HEV), the causative agent of human hepatitis E, is an important public health problem in developing countries, and is also endemic in the United States and other industrialized countries...
  14. ZOONOTIC AND XENOZOONOTIC RISKS OF HEPATITIS E VIRUS
    Xiang Jin Meng; Fiscal Year: 2001
    ..b>Hepatitis E virus (HEV), the causative agent of hepatitis E is an important human pathogen worldwide and causes very high ..
  15. Animal Model Research for Veterinarians (AMRV)
    Xiang Jin Meng; Fiscal Year: 2007
    ..At the end of the training program, trainees are expected to launch an independent biomedical research career. ..
  16. A Chicken Model to Study Hepatitis E Virus Pathogenesis
    Xiang Jin Meng; Fiscal Year: 2005
    b>Hepatitis E virus (HEV), the causative agent of hepatitis E, is an important public health problem in developing countries. HEV is also endemic in the U.S. The mortality rate is reportedly up to 20% in infected pregnant women...
  17. Epidemiology of Hep E Virus Infections in Bangladesh
    Kenrad Nelson; Fiscal Year: 2003
    b>Hepatitis E virus (HEV) infections cause serious morbidity and mortality, especially in pregnant women. Few population-based studies have characterized HEV epidemiology...
  18. THE EPIDEMIOLOGY OF HEPATITIS C INFECTION IN THAILAND
    Kenrad Nelson; Fiscal Year: 2004
    ..Through the transfer of technology for HCV research to our collaborators, we hope to focus on understanding the biology and epidemiology of HCV and the development of more effective prevention of HCV. ..
  19. Towards Understanding the Morbidity of HEV Infection
    Mohamed Tarek Shata; Fiscal Year: 2007
    b>Hepatitis E (HEV) is enterically transmitted RNA virus that causes acute viral hepatitis (AVH) in many lesser developed countries (LDC), with frequent reports of fulminant hepatitis in pregnant women...
  20. HCV Genotype 6: A Model for HCV Genetics and Molecular Epidemiology Studies
    Ling Lu; Fiscal Year: 2010
    ..This information and the derived models are vital for better strategies of HCV diagnosis and treatment, and the improved designs of antivirals and vaccines. ..
  21. Extrahepatic Replication and Viral Evolution of HCV During HCV/HIV Co-infection
    Jason Blackard; Fiscal Year: 2007
    ..This proposal will provide important data on co-factors of virus transmission and identify potential markers of HCV disease progression and treatment failure. ..