hepatitis e

Summary

Summary: Acute INFLAMMATION of the LIVER in humans; caused by HEPATITIS E VIRUS, a non-enveloped single-stranded RNA virus. Similar to HEPATITIS A, its incubation period is 15-60 days and is enterically transmitted, usually by fecal-oral transmission.

Top Publications

  1. doi Pig liver sausage as a source of hepatitis E virus transmission to humans
    Philippe Colson
    Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Fédération de Bactériologie Hygiène Virologie, Centre Hospitalo Universitaire Timone, Marseille, France
    J Infect Dis 202:825-34. 2010
  2. pmc Hepatitis E virus antibodies in blood donors, France
    Jean Michel Mansuy
    Hopital Purpan, Toulouse, France
    Emerg Infect Dis 17:2309-12. 2011
  3. ncbi Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial
    Feng Cai Zhu
    Jiangsu Provincial Centre for Disease Control and Prevention, Nanjing, Jiangsu Province, China
    Lancet 376:895-902. 2010
  4. pmc Hepatitis E virus: animal reservoirs and zoonotic risk
    X J Meng
    Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg VA, USA
    Vet Microbiol 140:256-65. 2010
  5. doi Hepatitis E
    Nassim Kamar
    Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Toulouse, France
    Lancet 379:2477-88. 2012
  6. ncbi Hepatitis E: an emerging infection in developed countries
    Harry R Dalton
    Peninsula College of Medicine and Dentistry, Royal Cornwall Hospital Trust, Truro, UK
    Lancet Infect Dis 8:698-709. 2008
  7. pmc From barnyard to food table: the omnipresence of hepatitis E virus and risk for zoonotic infection and food safety
    Xiang Jin Meng
    Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0913, USA
    Virus Res 161:23-30. 2011
  8. doi The serological prevalence and genetic diversity of hepatitis E virus in farmed rabbits in China
    Yansheng Geng
    Graduate School of Peking Union Medical College, 9 Dongdansantiao, Beijing 100730, China
    Infect Genet Evol 11:476-82. 2011
  9. ncbi Phylogenetic analysis of global hepatitis E virus sequences: genetic diversity, subtypes and zoonosis
    Ling Lu
    Division of Gastroenterology Hepatology, Department of Medicine, Kansas University Medical Center, Kansas City, Kansas 66160, USA
    Rev Med Virol 16:5-36. 2006
  10. pmc Novel hepatitis E virus genotype in Norway rats, Germany
    Reimar Johne
    Federal Institute for Risk Assessment, Berlin, Germany
    Emerg Infect Dis 16:1452-5. 2010

Research Grants

  1. Prevalence and Epidemiology of Hepatitis E Virus in the United States
    Kenrad Nelson; Fiscal Year: 2007
  2. Towards Understanding the Morbidity of HEV Infection
    Mohamed Tarek Shata; Fiscal Year: 2006
  3. DETERMINANTS OF HEPATITIS C & E MORBIDITY IN EGYPT
    George Strickland; Fiscal Year: 2000
  4. DETERMINANTS OF HEPATITIS C & E MORBIDITY IN EGYPT
    George Strickland; Fiscal Year: 2002
  5. DETERMINANTS OF HEPATITIS C & E MORBIDITY IN EGYPT
    George Strickland; Fiscal Year: 2003
  6. DETERMINANTS OF HEPATITIS C & E MORBIDITY IN EGYPT
    George Strickland; Fiscal Year: 2001
  7. DETERMINANTS OF HEPATITIS C & E MORBIDITY IN EGYPT
    George Strickland; Fiscal Year: 2004
  8. MOLECULAR BIOLOGY OF RUBELLA VIRUS
    TERYL FREY; Fiscal Year: 2005
  9. MOLECULAR BIOLOGY OF RUBELLA VIRUS
    TERYL FREY; Fiscal Year: 2003
  10. MOLECULAR BIOLOGY OF RUBELLA VIRUS
    TERYL FREY; Fiscal Year: 2006

Detail Information

Publications278 found, 100 shown here

  1. doi Pig liver sausage as a source of hepatitis E virus transmission to humans
    Philippe Colson
    Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Fédération de Bactériologie Hygiène Virologie, Centre Hospitalo Universitaire Timone, Marseille, France
    J Infect Dis 202:825-34. 2010
    The source and route of autochthonous hepatitis E virus (HEV) infections are not clearly established in industrialized countries despite evidence that it is a zoonosis in pigs...
  2. pmc Hepatitis E virus antibodies in blood donors, France
    Jean Michel Mansuy
    Hopital Purpan, Toulouse, France
    Emerg Infect Dis 17:2309-12. 2011
    Using a validated sensitive assay, we found hepatitis E virus (HEV) IgG in 52.5% of voluntary blood donors in southwestern France. This finding suggests HEV is highly endemic to this region...
  3. ncbi Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial
    Feng Cai Zhu
    Jiangsu Provincial Centre for Disease Control and Prevention, Nanjing, Jiangsu Province, China
    Lancet 376:895-902. 2010
    Seroprevalence data suggest that a third of the world's population has been infected with the hepatitis E virus...
  4. pmc Hepatitis E virus: animal reservoirs and zoonotic risk
    X J Meng
    Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg VA, USA
    Vet Microbiol 140:256-65. 2010
    b>Hepatitis E virus (HEV) is a small, non-enveloped, single-strand, positive-sense RNA virus of approximately 7.2kb in size...
  5. doi Hepatitis E
    Nassim Kamar
    Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Toulouse, France
    Lancet 379:2477-88. 2012
    b>Hepatitis E virus (HEV) was discovered during the Soviet occupation of Afghanistan in the 1980s, after an outbreak of unexplained hepatitis at a military camp...
  6. ncbi Hepatitis E: an emerging infection in developed countries
    Harry R Dalton
    Peninsula College of Medicine and Dentistry, Royal Cornwall Hospital Trust, Truro, UK
    Lancet Infect Dis 8:698-709. 2008
    b>Hepatitis E is endemic in many developing countries where it causes substantial morbidity. In industrialised countries, it is considered rare, and largely confined to travellers returning from endemic areas...
  7. pmc From barnyard to food table: the omnipresence of hepatitis E virus and risk for zoonotic infection and food safety
    Xiang Jin Meng
    Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0913, USA
    Virus Res 161:23-30. 2011
    b>Hepatitis E virus (HEV) is an important but extremely understudied pathogen. The mechanisms of HEV replication and pathogenesis are poorly understood, and a vaccine against HEV is not yet available...
  8. doi The serological prevalence and genetic diversity of hepatitis E virus in farmed rabbits in China
    Yansheng Geng
    Graduate School of Peking Union Medical College, 9 Dongdansantiao, Beijing 100730, China
    Infect Genet Evol 11:476-82. 2011
    We identified and characterized a novel virus, designated rabbit hepatitis E virus (HEV), in rex rabbits farmed in China...
  9. ncbi Phylogenetic analysis of global hepatitis E virus sequences: genetic diversity, subtypes and zoonosis
    Ling Lu
    Division of Gastroenterology Hepatology, Department of Medicine, Kansas University Medical Center, Kansas City, Kansas 66160, USA
    Rev Med Virol 16:5-36. 2006
    ..Accordingly, a total of 24 subtypes (1a, 1b, 1c, 1d, 1e, 2a, 2b, 3a, 3b, 3c, 3d, 3e, 3f, 3g, 3h, 3i, 3j, 4a, 4b, 4c, 4d, 4e, 4f and 4g) were given...
  10. pmc Novel hepatitis E virus genotype in Norway rats, Germany
    Reimar Johne
    Federal Institute for Risk Assessment, Berlin, Germany
    Emerg Infect Dis 16:1452-5. 2010
    Human hepatitis E virus infections may be caused by zoonotic transmission of virus genotypes 3 and 4...
  11. pmc Standardization of hepatitis E virus (HEV) nucleic acid amplification technique-based assays: an initial study to evaluate a panel of HEV strains and investigate laboratory performance
    Sally A Baylis
    Paul Ehrlich Institut, Paul Ehrlich Strasse 51 59, D 63225 Langen, Germany
    J Clin Microbiol 49:1234-9. 2011
    The performance of hepatitis E virus (HEV) RNA nucleic acid amplification (NAT)-based assays has been investigated using a panel of HEV-containing plasma samples...
  12. ncbi Detection of hepatitis E virus (HEV) from porcine livers in Southeastern Germany and high sequence homology to human HEV isolates
    Jürgen J Wenzel
    Institute of Medical Microbiology and Hygiene, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    J Clin Virol 52:50-4. 2011
    b>Hepatitis E virus (HEV) has been identified as an emerging cause of infectious hepatitis over the last years in developed countries...
  13. pmc Bats worldwide carry hepatitis E virus-related viruses that form a putative novel genus within the family Hepeviridae
    Jan Felix Drexler
    Institute of Virology, University of Bonn Medical Centre, Bonn, Germany
    J Virol 86:9134-47. 2012
    b>Hepatitis E virus (HEV) is one of the most common causes of acute hepatitis in tropical and temperate climates. Tropical genotypes 1 and 2 are associated with food-borne and waterborne transmission...
  14. doi Transmission routes and risk factors for autochthonous hepatitis E virus infection in Europe: a systematic review
    H C Lewis
    Department of Epidemiology, Statens Serum Institut, Copenhagen, Denmark
    Epidemiol Infect 138:145-66. 2010
    Increasing numbers of non-travel-associated hepatitis E virus (HEV) infections have been reported in Europe in recent years...
  15. doi Epidemiology of hepatitis E: current status
    Rakesh Aggarwal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Gastroenterol Hepatol 24:1484-93. 2009
    b>Hepatitis E, caused by infection with hepatitis E virus (HEV), is a common cause of acute hepatitis in areas with poor sanitation...
  16. doi Recent advances in Hepatitis E virus
    X J Meng
    Department of Biomedical Sciences and Pathobiology, Center for Molecular Medicine and Infectious Diseases, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA
    J Viral Hepat 17:153-61. 2010
    b>Hepatitis E virus (HEV), the causative agent of hepatitis E, belongs to the family Hepeviridae...
  17. ncbi Hepatitis E virus and chronic hepatitis in organ-transplant recipients
    Nassim Kamar
    Department of Nephrology, Dialysis, and Multiorgan Transplantation, Centre Hospitalier Universitaire, Rangueil, France
    N Engl J Med 358:811-7. 2008
    b>Hepatitis E virus (HEV) is considered an agent responsible for acute hepatitis that does not progress to chronic hepatitis...
  18. pmc Zoonotic hepatitis E: animal reservoirs and emerging risks
    Nicole Pavio
    Ecole Nationale Veterinaire d Alfort, 94704 Maisons Alfort, France
    Vet Res 41:46. 2010
    b>Hepatitis E virus (HEV) is responsible for enterically-transmitted acute hepatitis in humans with two distinct epidemiological patterns...
  19. doi Analysis of the full-length genome of a hepatitis E virus isolate obtained from a wild boar in Japan that is classifiable into a novel genotype
    Masaharu Takahashi
    Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Shimotsuke shi, Tochigi Ken 329 0498, Japan
    J Gen Virol 92:902-8. 2011
    While performing a nationwide survey of hepatitis E virus (HEV) infection among 450 wild boars (Sus scrofa leucomystax) that had been captured in Japan between November 2005 and March 2010, we found 16 boars (3...
  20. ncbi Detection and characterization of infectious Hepatitis E virus from commercial pig livers sold in local grocery stores in the USA
    A R Feagins
    Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA
    J Gen Virol 88:912-7. 2007
    b>Hepatitis E virus (HEV) is a zoonotic pathogen of which pigs are reservoirs...
  21. pmc Cross-species infections of cultured cells by hepatitis E virus and discovery of an infectious virus-host recombinant
    Priyanka Shukla
    Section of Molecular Hepatitis, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:2438-43. 2011
    The RNA virus, hepatitis E virus (HEV) is the most or second-most important cause of acute clinical hepatitis in adults throughout much of Asia, the Middle East, and Africa...
  22. ncbi Sporadic acute or fulminant hepatitis E in Hokkaido, Japan, may be food-borne, as suggested by the presence of hepatitis E virus in pig liver as food
    Yasuyuki Yazaki
    Center for Gastroenterology, Kobayashi Hospital, Hokkaido 090 8567, Japan
    J Gen Virol 84:2351-7. 2003
    Among ten patients who contracted sporadic acute or fulminant hepatitis E between 2001 and 2002 in Hokkaido, Japan, nine (90 %) had a history of consuming grilled or undercooked pig liver 2-8 weeks before the disease onset...
  23. pmc Molecular virology of hepatitis E virus
    Imran Ahmad
    Virology Group, International Centre for Genetic Engineering and Biotechnology ICGEB, Aruna Asaf Ali Marg, New Delhi, India
    Virus Res 161:47-58. 2011
    This review details the molecular virology of the hepatitis E virus (HEV)...
  24. ncbi Molecular biology and pathogenesis of hepatitis E virus
    Vivek Chandra
    Virology Group, International Centre for Genetic Engineering and Biotechnology ICGEB, New Delhi 110 067, India
    J Biosci 33:451-64. 2008
    The hepatitis E virus (HEV) is a small RNA virus and the etiological agent for hepatitis E, a form of acute viral hepatitis...
  25. doi Hepatitis E in Italy: a long-term prospective study
    Luisa Romano
    Dipartimento di Sanità Pubblica Microbiologia Virologia, Universita degli Studi di Milano, Via C Pascal 36, 20133 Milan, Italy
    J Hepatol 54:34-40. 2011
    In developed countries, hepatitis E is usually associated with travelling to endemic areas, but a growing number of sporadic cases are also seen in patients with no travel history...
  26. pmc Close similarity between sequences of hepatitis E virus recovered from humans and swine, France, 2008-2009
    Jerome Bouquet
    Anses, Laboratoire de Sante Animale, Maisons Alfort, France
    Emerg Infect Dis 17:2018-25. 2011
    Frequent zoonotic transmission of hepatitis E virus (HEV) has been suspected, but data supporting the animal origin of autochthonous cases are still sparse...
  27. pmc Restricted enzooticity of hepatitis E virus genotypes 1 to 4 in the United States
    Chen Dong
    Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Clin Microbiol 49:4164-72. 2011
    b>Hepatitis E is recognized as a zoonosis, and swine are known reservoirs, but how broadly enzootic its causative agent, hepatitis E virus (HEV), is remains controversial...
  28. doi Phylogenetic analysis of the full genome of rabbit hepatitis E virus (rbHEV) and molecular biologic study on the possibility of cross species transmission of rbHEV
    Jiabao Geng
    Institute of Hepatology, the 81st Hospital of PLA, Nanjing, Jiangsu Province, China
    Infect Genet Evol 11:2020-5. 2011
    ..positions as possibly being involved in specifying the host range of HEV and/or in determining the severity of hepatitis E disease, whereas this previous analysis did not extend to the new rabbit HEVs...
  29. ncbi The global burden of hepatitis E virus genotypes 1 and 2 in 2005
    David B Rein
    NORC at the University of Chicago, Atlanta, GA 30306, USA
    Hepatology 55:988-97. 2012
    We estimated the global burden of hepatitis E virus (HEV) genotypes 1 and 2 in 2005...
  30. pmc Epidemiology and risk factors of incident hepatitis E virus infections in rural Bangladesh
    Alain B Labrique
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Am J Epidemiol 172:952-61. 2010
    b>Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis in the world. Most of South Asia is HEV endemic, with frequent seasonal epidemics of hepatitis E and continuous sporadic cases...
  31. doi The two faces of hepatitis E virus
    Eyasu H Teshale
    National Center for HIV, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Clin Infect Dis 51:328-34. 2010
    b>Hepatitis E virus (HEV) has at least 2 distinct epidemiological profiles: (1) large outbreaks and epidemics in developing countries, usually caused by HEV genotype 1, resulting in high morbidity and mortality among pregnant women and ..
  32. pmc Hepatitis E virus in rats, Los Angeles, California, USA
    Robert H Purcell
    National Institutes of Health, Bethesda, Maryland, USA
    Emerg Infect Dis 17:2216-22. 2011
    The role of rats in human hepatitis E virus (HEV) infections remains controversial. A genetically distinct HEV was recently isolated from rats in Germany, and its genome was sequenced...
  33. pmc Acute hepatitis E infection accounts for some cases of suspected drug-induced liver injury
    Timothy J Davern
    Department of Transplantation, California Pacific Medical Center, San Francisco, California, USA
    Gastroenterology 141:1665-72.e1-9. 2011
    ..b>Hepatitis E virus (HEV) infection has been proposed as another cause of suspected drug-induced liver disease...
  34. ncbi Liver transplant from a donor with occult HEV infection induced chronic hepatitis and cirrhosis in the recipient
    B Schlosser
    Department of Gastroenterology and Hepatology, Charite University Medicine, Campus Virchow Klinikum, Berlin, Germany
    J Hepatol 56:500-2. 2012
    Acute hepatitis E virus (HEV) infection is a self-limiting symptomatic or asymptomatic disease...
  35. pmc Hepatitis E Virus seroprevalence and chronic infections in patients with HIV, Switzerland
    Alain Kenfak-Foguena
    Centre Hospitalier Universitaire Vaudois and Lausanne University, Lausanne, Switzerland
    Emerg Infect Dis 17:1074-8. 2011
    We screened 735 HIV-infected patients in Switzerland with unexplained alanine aminotransferase elevation for hepatitis E virus (HEV) immunoglobulin G. Although HEV seroprevalence in this population is low (2...
  36. ncbi Monoclonal antibodies raised against the ORF3 protein of hepatitis E virus (HEV) can capture HEV particles in culture supernatant and serum but not those in feces
    Masaharu Takahashi
    Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, 3311 1 Yakushiji, Shimotsuke shi, Tochigi Ken 329 0498, Japan
    Arch Virol 153:1703-13. 2008
    ..a synthetic peptide corresponding to the well-conserved, C-terminal 24-amino acid portion of ORF3 protein of hepatitis E virus (HEV) were produced and characterized...
  37. pmc Deletions of the hypervariable region (HVR) in open reading frame 1 of hepatitis E virus do not abolish virus infectivity: evidence for attenuation of HVR deletion mutants in vivo
    R S Pudupakam
    Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, 1410 Price s Fork Road, Blacksburg, VA 24061 0342, USA
    J Virol 83:384-95. 2009
    b>Hepatitis E virus (HEV) is an important human pathogen, although little is known about its biology and replication...
  38. doi Phylogenetic and case-control study on hepatitis E virus infection in Germany
    Ole Wichmann
    Department of Infectious Disease Epidemiology, Robert Koch Institute, Germany
    J Infect Dis 198:1732-41. 2008
    b>Hepatitis E is a classic water-borne disease in developing countries. In Germany, hepatitis E virus (HEV) infections are notifiable...
  39. pmc Prevalence of hepatitis E virus in Chinese blood donors
    Qing Shun Guo
    National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen 361005, China
    J Clin Microbiol 48:317-8. 2010
    A point prevalence study of hepatitis E virus (HEV) in Chinese blood donors was conducted, and the prevalences of antibodies against HEV immunoglobulin G (IgG) and IgM among Chinese blood donors were 32.60% and 0.94%, respectively...
  40. pmc Profile of acute infectious markers in sporadic hepatitis E
    Shoujie Huang
    National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, China
    PLoS ONE 5:e13560. 2010
    Laboratory diagnosis of acute infection of hepatitis E virus (HEV) is commonly based on the detection of HEV RNA, IgM and/or rising IgG levels. However, the profile of these markers when the patients present have not been well determined...
  41. doi Chronic hepatitis E virus infection in liver transplant recipients
    Elizabeth B Haagsma
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, The Netherlands
    Liver Transpl 14:547-53. 2008
    b>Hepatitis E virus (HEV) infection is known to run a self-limiting course. Sporadic cases of acute hepatitis due to infection with HEV genotype 3, present in pig populations, are increasingly recognized...
  42. ncbi Hepatitis E virus
    Mohammad S Khuroo
    Digestive Disease Centre, Dr Khuroo s Medical Clinic, Srinagar, India
    Curr Opin Infect Dis 21:539-43. 2008
    b>Hepatitis E is an emerging infectious disease. This review will focus on recent advances in the zoonotic transmission, global distribution and control of hepatitis E.
  43. pmc Hepatitis E virus infection in central China reveals no evidence of cross-species transmission between human and swine in this area
    Wen Zhang
    School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai, People s Republic of China
    PLoS ONE 4:e8156. 2009
    b>Hepatitis E virus (HEV) is a zoonotic pathogen of which several species of animal were reported as reservoirs...
  44. pmc Polyphyletic strains of hepatitis E virus are responsible for sporadic cases of acute hepatitis in Japan
    Hitoshi Mizuo
    Department of Internal Medicine, Kin ikyo chuo Hospital, Hokkaido 007 0870, Japan
    J Clin Microbiol 40:3209-18. 2002
    ..and 2001 at five hospitals in Japan, 11 (13%) patients were positive for immunoglobulin M-class antibodies to hepatitis E virus (HEV) by enzyme immunoassay and had detectable HEV RNA by reverse transcription-PCR with two independent ..
  45. doi Serologic assays specific to immunoglobulin M antibodies against hepatitis E virus: pangenotypic evaluation of performances
    Jan Drobeniuc
    Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Clin Infect Dis 51:e24-7. 2010
    Six immunoassays for detecting immunoglobulin M antibodies to hepatitis E virus were evaluated...
  46. pmc Release of genotype 1 hepatitis E virus from cultured hepatoma and polarized intestinal cells depends on open reading frame 3 protein and requires an intact PXXP motif
    Suzanne U Emerson
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, MSC 8009, Bethesda, MD 20892, USA
    J Virol 84:9059-69. 2010
    b>Hepatitis E virus genotype 1 strain Sar55 replicated in subcloned Caco-2 intestinal cells and Huh7 hepatoma cells that had been transfected with in vitro transcribed viral genomes, and hepatitis E virions were released into the culture ..
  47. pmc Clinical and epidemiological relevance of quantitating hepatitis E virus-specific immunoglobulin M
    Jitvimol Seriwatana
    Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    Clin Diagn Lab Immunol 9:1072-8. 2002
    Diagnosis of acute hepatitis E by detection of hepatitis E virus (HEV)-specific immunoglobulin M (IgM) is an established procedure...
  48. pmc Use of serological assays for diagnosis of hepatitis E virus genotype 1 and 3 infections in a setting of low endemicity
    M Herremans
    National Institute for Public Health and the Environment, RIVM, Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Clin Vaccine Immunol 14:562-8. 2007
    Because of the occurrence of genotype 3 hepatitis E virus (HEV) in regions of low endemicity, it is important to validate the currently used serological assays for diagnosing infections with viruses belonging to this lineage, since these ..
  49. pmc Prevalence of antibodies to hepatitis E virus in veterinarians working with swine and in normal blood donors in the United States and other countries
    X J Meng
    Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0342, USA
    J Clin Microbiol 40:117-22. 2002
    b>Hepatitis E virus (HEV) is endemic in many developing and some industrialized countries. It has been hypothesized that animals may be the source of infection. The recent identification of swine HEV in U.S...
  50. doi Hepatitis E: an emerging awareness of an old disease
    R H Purcell
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892 8009, USA
    J Hepatol 48:494-503. 2008
    Although hepatitis E was recognized as a new disease in 1980, the virus was first visualized in 1983 and its genome was cloned and characterized in 1991, the disease is probably ancient but not recognized until modern times...
  51. ncbi A comparison of two commercially available anti-HEV IgG kits and a re-evaluation of anti-HEV IgG seroprevalence data in developed countries
    Richard Bendall
    Clinical Microbiology, Royal Cornwall Hospital Trust, Truro, United Kingdom
    J Med Virol 82:799-805. 2010
    In developed countries, the incidence of hepatitis E virus (HEV) infection and the resulting seroprevalence are uncertain. Published estimates of seroprevalnce in these populations range from 0...
  52. pmc The nucleotides on the stem-loop RNA structure in the junction region of the hepatitis E virus genome are critical for virus replication
    Dianjun Cao
    Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0913, USA
    J Virol 84:13040-4. 2010
    The roles of conserved nucleotides on the stem-loop (SL) structure in the intergenic region of the hepatitis E virus (HEV) genome in virus replication were determined by using Huh7 cells transfected with HEV SL mutant replicons ..
  53. doi The molecular epidemiology of hepatitis E virus infection
    Michael A Purdy
    Centers for Disease Control and Prevention, National Center for HIV Hepatitis STD TB Prevention, Division of Viral Hepatitis, Atlanta, GA 30333, USA
    Virus Res 161:31-9. 2011
    Molecular characterization of various hepatitis E virus (HEV) strains circulating among humans and animals (particularly swine, deer and boars) in different countries has revealed substantial genetic heterogeneity...
  54. doi The incidence of hepatitis E virus infection in the general population of the USA
    M F Faramawi
    Epidemiology Department, School of Public Health, University of North Texas Health Science Center, Fort Worth, TX, USA
    Epidemiol Infect 139:1145-50. 2011
    b>Hepatitis E virus (HEV) infection is as an emerging disease of global importance because it is one of the major causes of acute hepatitis worldwide. There are few reports on the incidence of HEV in the USA...
  55. doi A systematic review/meta-analysis of primary research investigating swine, pork or pork products as a source of zoonotic hepatitis E virus
    B J Wilhelm
    Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, Guelph, Ontario, Canada
    Epidemiol Infect 139:1127-44. 2011
    ..of our study were to identify and categorize primary research investigating swine/pork as a source of zoonotic hepatitis E virus (HEV) using the relatively new technique of scoping study, and to investigate the potential association ..
  56. doi Factors associated with chronic hepatitis in patients with hepatitis E virus infection who have received solid organ transplants
    Nassim Kamar
    Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Toulouse, France
    Gastroenterology 140:1481-9. 2011
    b>Hepatitis E virus (HEV) infection can cause chronic hepatitis in recipients of solid organ transplants. However, the factors that contribute to chronic infection and the outcomes of these patients are incompletely understood...
  57. ncbi Acute hepatitis E virus infection in Taiwan 2002-2006 revisited: PCR shows frequent co-infection with multiple hepatitis viruses
    Kuan Ta Wu
    Department of General Medicine, Chi Mei Medical Center, Tainan, Taiwan
    J Med Virol 81:1734-42. 2009
    Sporadic cases of acute hepatitis E virus (HEV) infection with production of anti-HEV IgM have been reported occasionally in Taiwan despite no reported outbreaks in the past...
  58. doi Ribavirin therapy inhibits viral replication on patients with chronic hepatitis e virus infection
    Nassim Kamar
    Department of Nephrology, Dialysis and Organ Transplantation, CHU Rangueil, Toulouse, France
    Gastroenterology 139:1612-8. 2010
    b>Hepatitis E virus (HEV) infection can evolve to chronic hepatitis in immunocompromised patients...
  59. pmc Identical consensus sequence and conserved genomic polymorphism of hepatitis E virus during controlled interspecies transmission
    Jerome Bouquet
    UMR 1161 Virology, Anses, Laboratoire de Sante Animale, Maisons Alfort, France
    J Virol 86:6238-45. 2012
    High-throughput sequencing of bile and feces from two pigs experimentally infected with human hepatitis E virus (HEV) of genotype 3f revealed the same full-length consensus sequence as in the human sample...
  60. doi Hepatitis E virus in Italy: molecular analysis of travel-related and autochthonous cases
    Giuseppina La Rosa
    Istituto Superiore di Sanita, Department of Environment and Primary Prevention, Rome, Italy
    J Gen Virol 92:1617-26. 2011
    Human hepatitis E virus (HEV) is considered an emerging pathogen in industrialized countries. The aim of the present study was to contribute to the body of knowledge available on the molecular epidemiology of acute hepatitis E in Italy...
  61. doi Discovery of hepatitis E: the epidemic non-A, non-B hepatitis 30 years down the memory lane
    Mohammad Sultan Khuroo
    Gastroenterology, Digestive Diseases Centre, Kashmir, J and K, India
    Virus Res 161:3-14. 2011
    b>Hepatitis E was first recognised during an epidemic of hepatitis, which occurred in Kashmir Valley in 1978. The epidemic involved an estimated 52,000 cases of icteric hepatitis with 1700 deaths...
  62. doi Rat hepatitis E virus: geographical clustering within Germany and serological detection in wild Norway rats (Rattus norvegicus)
    Reimar Johne
    Federal Institute for Risk Assessment, Berlin, Germany
    Infect Genet Evol 12:947-56. 2012
    Zoonotic hepatitis E virus (HEV) infection in industrialised countries is thought to be caused by transmission from wild boar, domestic pig and deer as reservoir hosts...
  63. ncbi Evaluation of antibody-based and nucleic acid-based assays for diagnosis of hepatitis E virus infection in a rhesus monkey model
    Jun Zhang
    The Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, Fujian Province, 361005, China
    J Med Virol 71:518-26. 2003
    We have evaluated four hepatitis E virus (HEV) specific antibody assays, using sequential samples taken from 86 rhesus monkeys at intervals for up to 86 weeks after they had been infected with different doses of HEV...
  64. doi Hepatitis E virus excretion can be prolonged in patients with hematological malignancies
    Suzanne Tavitian
    Service d Hematologie, CHU de Toulouse, Hopital Purpan, Place du Dr Baylac, 31059 Toulouse Cedex, France
    J Clin Virol 49:141-4. 2010
    b>Hepatitis E virus (HEV) is transmitted via the fecal-oral route and locally acquired sporadic hepatitis E can occur in Western countries...
  65. doi Study of cellular immune response against Hepatitis E virus (HEV)
    S B Prabhu
    Department of Pathology, All India Institute of Medical Sciences, New Delhi, India
    J Viral Hepat 18:587-94. 2011
    b>Hepatitis E virus infection (HEV) is a major cause of acute viral hepatitis in the developing world. The immunopathology of HEV infections has not yet been elucidated...
  66. pmc Hepatitis E virus in rabbits, Virginia, USA
    Caitlin M Cossaboom
    Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0913, USA
    Emerg Infect Dis 17:2047-9. 2011
    We identified hepatitis E virus (HEV) in rabbits in Virginia, USA. HEV RNA was detected in 14 (16%) of 85 serum samples and 13 (15%) of 85 fecal samples. Antibodies against HEV were detected in 31 (36%) of 85 serum samples...
  67. doi Serological diagnostics of hepatitis E virus infection
    Yury Khudyakov
    Centers for Disease Control and Prevention, National Center for HIV Hepatitis STD TB Prevention, Division of Viral Hepatitis, Atlanta, GA 30333, USA
    Virus Res 161:84-92. 2011
    Development of accurate diagnostic assays for the detection of serological markers of hepatitis E virus (HEV) infection remains challenging...
  68. doi Structure of hepatitis E viral particle
    Yoshio Mori
    Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    Virus Res 161:59-64. 2011
    b>Hepatitis E is acute hepatitis caused by infection of hepatitis E virus (HEV) via a fecal-to-oral or zoonotic route. HEV is a small, non-enveloped virus containing positive strand RNA as a genome...
  69. doi Hepatitis E virus ORF3 antigens derived from genotype 1 and 4 viruses are detected with varying efficiencies by an anti-HEV enzyme immunoassay
    Hongxia Ma
    Department of Cell Biology, National Institute for Control of Pharmaceutical and Biological Products, Beijing, China
    J Med Virol 83:827-32. 2011
    The function of the hepatitis E virus (HEV) open reading frame 3 (ORF3) protein product remains unclear but it is able to induce a strong antibody response following HEV infection...
  70. doi Viral load, antibody titers and recombinant open reading frame 2 protein-induced TH1/TH2 cytokines and cellular immune responses in self-limiting and fulminant hepatitis e
    S Saravanabalaji
    Hepatitis Group, National Institute of Virology, BJ Medical College, 130 1 Sus Road, Pashan Pune, Maharashtra, India
    Intervirology 52:78-85. 2009
    b>Hepatitis E virus (HEV) is the predominant cause of water-borne epidemics, sporadic acute viral hepatitis (AVH) in adults and fulminant hepatic failure (FHF) among pregnant women and other adults in India...
  71. ncbi Unexpected high prevalence of IgG-antibodies to hepatitis E virus in Swedish pig farmers and controls
    Bjorn Olsen
    Department of Infectious Diseases, Umea University, and Department of Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Scand J Infect Dis 38:55-8. 2006
    b>Hepatitis E virus (HEV) infections are responsible for large waterborne outbreaks in developing countries. Sporadic cases in the developed world are mainly imported via immigrants and travellers from endemic areas...
  72. pmc Time trend of the prevalence of hepatitis E antibodies among farmers and blood donors: a potential zoonosis in Denmark
    Peer B Christensen
    Department of Infectious Diseases, Odense University Hospital, Denmark
    Clin Infect Dis 47:1026-31. 2008
    Antibody to hepatitis E virus (anti-HEV) is prevalent in Western countries, where clinical hepatitis E is rarely reported. The aim of this study was to determine the prevalence of anti-HEV among Danish blood donors and Danish farmers...
  73. doi Hepatitis E virus in Isfahan Province: a population-based study
    Behrooz Ataei
    Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
    Int J Infect Dis 13:67-71. 2009
    b>Hepatitis E virus (HEV) is an enterically transmitted acute viral hepatitis with the highest incidence in Asia, Africa, the Middle East, and Central America. There are few published data on the epidemiology of the infection in Iran...
  74. ncbi Hepatitis E virus infection and fulminant hepatic failure during pregnancy
    Nishat Jilani
    Department of Medicine, Maulana Azad Medical College and Associated Lok Nayak Hospital, Jamia Millia Islamia, New Delhi, India
    J Gastroenterol Hepatol 22:676-82. 2007
    b>Hepatitis E virus (HEV) infection leading to fulminant hepatic failure (FHF) and high mortality is a common feature in Indian women during the second and third trimesters of pregnancy...
  75. doi Autochthonous hepatitis E in Southwest England: natural history, complications and seasonal variation, and hepatitis E virus IgG seroprevalence in blood donors, the elderly and patients with chronic liver disease
    Harry R Dalton
    Cornwall Gastrointestinal Unit, Royal Cornwall Hospital Trust, Truro, Cornwall, UK
    Eur J Gastroenterol Hepatol 20:784-90. 2008
    To report the natural history of autochthonous hepatitis E and hepatitis E virus (HEV) IgG seroprevalence in Southwest England.
  76. ncbi Hepatitis E virus antibodies in hemodialysis patients: an epidemiological survey in central Greece
    I Stefanidis
    University of Thessalia, School of Medicine, Larissa Greece
    Int J Artif Organs 27:842-7. 2004
    b>Hepatitis E virus (HEV) is the causative agent for enteric non-A, non-B hepatitis. Transmission is mainly via the fecal-oral route but the possibility of an additional parenteric transmission has been raised...
  77. pmc Identification by phage display and characterization of two neutralizing chimpanzee monoclonal antibodies to the hepatitis E virus capsid protein
    D J Schofield
    Hepatitis Viruses, National Institutes of Health, Bethesda, Maryland 20852, USA
    J Virol 74:5548-55. 2000
    Two monoclonal antibodies (MAbs) against the ORF2 protein of the SAR-55 strain of hepatitis E virus (HEV) were isolated by phage display from a cDNA library of chimpanzee (Pan troglodytes) gamma1/kappa antibody genes...
  78. ncbi Hepatitis E virus-related cirrhosis in kidney- and kidney-pancreas-transplant recipients
    N Kamar
    Department of Nephrology, Dialysis and Multi Organ Transplantation, and INSERM U858, IFR 31, CHU Rangueil, Toulouse, France
    Am J Transplant 8:1744-8. 2008
    b>Hepatitis E virus (HEV) infection was thought to be responsible for acute hepatitis that did not become chronic...
  79. doi Seroepidemiology and genetic characterization of hepatitis E virus in the northeast of China
    Yuanhua Yu
    School of Life Science and Technology, Changchun University of Science and Technology, Changchun, PR China
    Infect Genet Evol 9:554-61. 2009
    The aim of this study was to analyze the prevalence of infection and genotype of hepatitis E virus (HEV) in people and animals in the northeast of China (Heilongjiang, Jilin and Liaoning provinces)...
  80. pmc Identification of swine hepatitis E virus (HEV) and prevalence of anti-HEV antibodies in swine and human populations in Korea
    In Soo Choi
    Department of Infectious Diseases, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Seoul 151 742, Korea
    J Clin Microbiol 41:3602-8. 2003
    The swine hepatitis E virus (HEV) is considered to be a new zoonotic agent due to its close genomic resemblance to the human HEV and its ability to infect nonhuman primates...
  81. pmc In vitro replication of hepatitis E virus (HEV) genomes and of an HEV replicon expressing green fluorescent protein
    Suzanne U Emerson
    Laboratory of Infectious Diseases and Flow Cytometry Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 8009, USA
    J Virol 78:4838-46. 2004
    b>Hepatitis E virus (HEV) RNA replication occurred in seven of nine primate cell cultures transfected with in vitro transcripts of an infectious cDNA clone...
  82. pmc Development and characterization of a genotype 4 hepatitis E virus cell culture system using a HE-JF5/15F strain recovered from a fulminant hepatitis patient
    Toshinori Tanaka
    Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, 3311 1 Yakushiji, Shimotsuke shi, Tochigi Ken 329 0498, Japan
    J Clin Microbiol 47:1906-10. 2009
    We developed an efficient cell culture system for genotype 4 hepatitis E virus using the HE-JF5/15F strain recovered from a fulminant hepatitis patient. The sixth-passage virus in the culture supernatant reached 1...
  83. pmc Structure of hepatitis E virion-sized particle reveals an RNA-dependent viral assembly pathway
    Li Xing
    Department of Molecular and Cellular Biology, University of California, Davis, California 95616, USA
    J Biol Chem 285:33175-83. 2010
    b>Hepatitis E virus (HEV) induces acute hepatitis in humans with a high fatality rate in pregnant women. There is a need for anti-HEV research to understand the assembly process of HEV native capsid...
  84. ncbi A review of hepatitis E virus
    J L Smith
    US Department of Agriculture, Agricultural Research Service, Eastern Regional Research Center, Wyndmoor, Pennsylvania 19038, USA
    J Food Prot 64:572-86. 2001
    b>Hepatitis E virus (HEV) is a major cause of outbreaks and sporadic cases of viral hepatitis in tropical and subtropical countries but is infrequent in industrialized countries...
  85. pmc Detection by reverse transcription-PCR and genetic characterization of field isolates of swine hepatitis E virus from pigs in different geographic regions of the United States
    F F Huang
    Center for Molecular Medicine and Infectious Diseases, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0342, USA
    J Clin Microbiol 40:1326-32. 2002
    b>Hepatitis E virus (HEV) is an important public health concern in many developing countries. HEV is also endemic in some industrialized counties, including the United States...
  86. pmc Hepatitis E virus epidemiology in industrialized countries
    Pilar Clemente-Casares
    University of Barcelona, Barcelona, Spain
    Emerg Infect Dis 9:448-54. 2003
    To determine the prevalence of Hepatitis E virus (HEV) in industrialized nations, we analyzed the excretion of HEV strains by the populations of Spain, France, Greece, Sweden, and the United States. Twenty of 46 (43...
  87. ncbi Hepatitis E virus: molecular virology, clinical features, diagnosis, transmission, epidemiology, and prevention
    Isa K Mushahwar
    Infectious Disease Diagnostics, Tierra Verde, Florida 33715, USA
    J Med Virol 80:646-58. 2008
    b>Hepatitis E virus (HEV), the sole member of the genus Hepevirus in the family of Hepeviridae, is the major cause of several outbreaks of waterborne hepatitis in tropical and subtropical countries and of sporadic cases of viral hepatitis ..
  88. ncbi Swine hepatitis E virus: cross-species infection and risk in xenotransplantation
    X J Meng
    Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, 1410 Price s Fork Road, Blacksburg, VA 24061 0342, USA
    Curr Top Microbiol Immunol 278:185-216. 2003
    Swine hepatitis E Virus (swine HEV), a ubiquitous agent recently discovered in pigs, is antigenically and genetically closely related to the human HEV...
  89. pmc Hepatitis E, Central African Republic
    Josep M Escribà
    Emerg Infect Dis 14:681-3. 2008
  90. ncbi Mutational events during the primary propagation and consecutive passages of hepatitis E virus strain JE03-1760F in cell culture
    Felipe R Lorenzo
    Department of Infection and Immunity, Division of Virology, Jichi Medical University School of Medicine, Shimotsuke shi, Tochigi ken, Japan
    Virus Res 137:86-96. 2008
    We recently developed a cell culture system for hepatitis E virus (HEV) in PLC/PRF/5 cells, using a genotype 3 HEV (JE03-1760F strain)...
  91. ncbi Prevalence and genotyping of hepatitis E virus in swine population in Korea between 1995 and 2004: a retrospective study
    K Jung
    Department of Veterinary Pathology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Kwanak Gu 151 742, Seoul, Republic of Korea
    Vet J 173:683-7. 2007
    b>Hepatitis E virus (HEV) infections have been reported in pigs throughout the world but have only recently been recorded in Korean pigs...
  92. pmc Sources of hepatitis E virus genotype 3 in The Netherlands
    Saskia A Rutjes
    Laboratory for Zoonoses and Environmental Microbiology, Centre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Emerg Infect Dis 15:381-7. 2009
    Non-travel-related hepatitis E virus (HEV) genotype 3 infections in persons in the Netherlands may have a zoonotic, foodborne, or water-borne origin. Possible reservoirs for HEV transmission by water, food, and animals were studied...
  93. pmc Characterization of hepatitis E-specific cell-mediated immune response using IFN-gamma ELISPOT assay
    M T Shata
    Internal Medicine, Division of Digestive Diseases, University of Cincinnati, Cincinnati, OH 45267 0595, USA
    J Immunol Methods 328:152-61. 2007
    In developing countries, hepatitis E (HEV) and hepatitis A (HAV) are the major causes of acute viral hepatitis with similar feco-oral modes of transmission...
  94. ncbi [Liver cirrhosis due to hepatitis E in a kidney transplant patient]
    Yolanda Verhoeven
    Ziekenhuis Gelderse Vallei, afd Interne Geneeskunde, Ede, The Netherlands
    Ned Tijdschr Geneeskd 154:A1790. 2010
    Until recently, hepatitis E was considered to be an infectious disease that resolved without any long-term complications...
  95. ncbi Detection rates of the swine torque teno viruses (TTVs), porcine circovirus type 2 (PCV2) and hepatitis E virus (HEV) in the livers of pigs with hepatitis
    Bozidar Savic
    Department for Swine Diseases, Institute of Veterinary Medicine Belgrade, Serbia, V Toze 14, 11 000, Belgrade, Serbia
    Vet Res Commun 34:641-8. 2010
    Porcine circovirus type 2 (PCV2) and hepatitis E virus (HEV) are the most recently recognized causes of infectious hepatitis of pigs and may or may not act independently in the development of the disease...
  96. doi Hepatitis E virus infection as a cause of graft hepatitis in liver transplant recipients
    Sven Pischke
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    Liver Transpl 16:74-82. 2010
    b>Hepatitis E virus (HEV) infection induces self-limiting liver disease in immunocompetent individuals. Cases of chronic hepatitis E have recently been identified in organ transplant recipients...
  97. ncbi Effect of acute hepatitis E infection in patients with liver cirrhosis
    S KC
    Liver Unit Bir Hospital, National Academy of Medical Sciences, Kathmandu, Nepal
    JNMA J Nepal Med Assoc 48:226-9. 2009
    b>Hepatitis E virus is a major cause of enterically transmitted hepatitis. Mortality is very high if it is associated with pregnancy, especially during third trimester...
  98. ncbi Intrafamilial hepatitis E in France
    A Ducancelle
    Laboratoire de Bacteriologie virologie, CHU Angers, Paris
    J Clin Virol 39:51-3. 2007
  99. ncbi Locally acquired hepatitis E in chronic liver disease
    H R Dalton
    Lancet 369:1260. 2007
  100. doi Seroepidemiology and molecular characterization of hepatitis E virus in Jilin, China
    G Zhu
    Genetic Engineering Laboratory, Academy of Military Medical Sciences, 1068 Qinglong Road, Changchun, 130062, People s Republic of China
    Infection 36:140-6. 2008
    In order to develop region-specific diagnostic assays and prevent hepatitis E virus (HEV), it is essential to understand epidemiology and genotypic variation within different populations...
  101. ncbi Hepatitis E virus infection: a general review with a focus on hemodialysis and kidney transplant patients
    Seyed Mohammadmehdi Hosseini-Moghaddam
    Infectious Diseases and Tropical Medicine, Urology and Nephrology Research Center, Shahid Beheshti University, Tehran, Islamic Republic of Iran h_sasan hotmail com
    Am J Nephrol 31:398-407. 2010
    b>Hepatitis E virus (HEV) infection is a self-limited viral disease that causes acute hepatitis epidemics in developing countries. The common route of transmission for HEV is supposedly fecal-oral...

Research Grants62

  1. Prevalence and Epidemiology of Hepatitis E Virus in the United States
    Kenrad Nelson; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Hepatitis E virus (HEV) is the etiologic agent responsible for large outbreaks of clinical hepatitis in developing countries and a large proportion of sporadic clinical hepatitis in ..
  2. Towards Understanding the Morbidity of HEV Infection
    Mohamed Tarek Shata; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Hepatitis E (HEV) is enterically transmitted RNA virus that causes acute viral hepatitis (AVH) in many lesser developed countries (LDC), with frequent reports of fulminant hepatitis in ..
  3. DETERMINANTS OF HEPATITIS C & E MORBIDITY IN EGYPT
    George Strickland; Fiscal Year: 2000
    ..been categorized into those infected with hepatitis C virus (HCV), a parenterally transmitted flavivirus, and hepatitis E virus (HEV), a fecal-oral transmitted "hepatitis E-like virus...
  4. DETERMINANTS OF HEPATITIS C & E MORBIDITY IN EGYPT
    George Strickland; Fiscal Year: 2002
    ..been categorized into those infected with hepatitis C virus (HCV), a parenterally transmitted flavivirus, and hepatitis E virus (HEV), a fecal-oral transmitted "hepatitis E-like virus...
  5. DETERMINANTS OF HEPATITIS C & E MORBIDITY IN EGYPT
    George Strickland; Fiscal Year: 2003
    ..been categorized into those infected with hepatitis C virus (HCV), a parenterally transmitted flavivirus, and hepatitis E virus (HEV), a fecal-oral transmitted "hepatitis E-like virus...
  6. DETERMINANTS OF HEPATITIS C & E MORBIDITY IN EGYPT
    George Strickland; Fiscal Year: 2001
    ..been categorized into those infected with hepatitis C virus (HCV), a parenterally transmitted flavivirus, and hepatitis E virus (HEV), a fecal-oral transmitted "hepatitis E-like virus...
  7. DETERMINANTS OF HEPATITIS C & E MORBIDITY IN EGYPT
    George Strickland; Fiscal Year: 2004
    ..been categorized into those infected with hepatitis C virus (HCV), a parenterally transmitted flavivirus, and hepatitis E virus (HEV), a fecal-oral transmitted "hepatitis E-like virus...
  8. MOLECULAR BIOLOGY OF RUBELLA VIRUS
    TERYL FREY; Fiscal Year: 2005
    ..pathogenesis and are of evolutionary interest in that, by computer alignment, they are more closely related to hepatitis E virus (HEV, an unclassified enteric virus) than to the alphaviruses, the other Togavirus genus...
  9. MOLECULAR BIOLOGY OF RUBELLA VIRUS
    TERYL FREY; Fiscal Year: 2003
    ..pathogenesis and are of evolutionary interest in that, by computer alignment, they are more closely related to hepatitis E virus (HEV, an unclassified enteric virus) than to the alphaviruses, the other Togavirus genus...
  10. MOLECULAR BIOLOGY OF RUBELLA VIRUS
    TERYL FREY; Fiscal Year: 2006
    ..pathogenesis and are of evolutionary interest in that, by computer alignment, they are more closely related to hepatitis E virus (HEV, an unclassified enteric virus) than to the alphaviruses, the other Togavirus genus...
  11. MOLECULAR BIOLOGY OF RUBELLA VIRUS
    TERYL FREY; Fiscal Year: 2004
    ..pathogenesis and are of evolutionary interest in that, by computer alignment, they are more closely related to hepatitis E virus (HEV, an unclassified enteric virus) than to the alphaviruses, the other Togavirus genus...
  12. MOLECULAR BIOLOGY OF RUBELLA VIRUS
    TERYL FREY; Fiscal Year: 2004
    ..pathogenesis and are of evolutionary interest in that, by computer alignment, they are more closely related to hepatitis E virus (HEV, an unclassified enteric virus) than to the alphaviruses, the other Togavirus genus...
  13. MOLECULAR BIOLOGY OF RUBELLA VIRUS
    TERYL FREY; Fiscal Year: 1999
    ..As part of this effort, the NSP open reading frame (ORF1) of hepatitis E virus (HEV) will be expressed to analyze its processing...
  14. MOLECULAR BIOLOGY OF RUBELLA VIRUS
    TERYL FREY; Fiscal Year: 1999
    ..As part of this effort, the NSP open reading frame (ORF1) of hepatitis E virus (HEV) will be expressed to analyze its processing...
  15. PATHOGENESIS OF THE HEPATITIS E VIRUS: A SWINE MODEL
    Xiang Jin Meng; Fiscal Year: 1999
    b>Hepatitis E virus (HEV), the causative agent of hepatitis E, is an important public health problem in developing countries. HEV is also considered to be endemic in the United States (U.S). HEV strains recovered from patients in the U.S...
  16. MOLECULAR BIOLOGY OF RUBELLA VIRUS
    TERYL FREY; Fiscal Year: 2000
    ..As part of this effort, the NSP open reading frame (ORF1) of hepatitis E virus (HEV) will be expressed to analyze its processing...
  17. PATHOGENESIS OF THE HEPATITIS E VIRUS: A SWINE MODEL
    Xiang Jin Meng; Fiscal Year: 2000
    b>Hepatitis E virus (HEV), the causative agent of hepatitis E, is an important public health problem in developing countries. HEV is also considered to be endemic in the United States (U.S). HEV strains recovered from patients in the U.S...
  18. LAMIVUDINE IN PEDIATRIC SUBJECTS WITH HEPATITIS B
    ERIC MALLER; Fiscal Year: 2000
    ..Two patients enrolled in our center. One patient has finished uneventfully but remains positive for hepatitis e-antigen...
  19. CHARACTERIZATION OF HUMAN CALICIVIRUS
    Xi Jiang; Fiscal Year: 2001
    ..HuCVs include three genogroups: Norwalk virus (NV), Sapporo and Hepatitis E genogroups. The NV genogroup can be divided further into NV-like and Snow Mountain agent (SMA)-like HuCVs...
  20. CHARACTERIZATION OF HUMAN CALICIVIRUS
    Xi Jiang; Fiscal Year: 2001
    ..HuCVs include three genogroups: Norwalk virus (NV), Sapporo and Hepatitis E genogroups. The NV genogroup can be divided further into NV-like and Snow Mountain agent (SMA)-like HuCVs...
  21. CHARACTERIZATION OF HUMAN CALICIVIRUS
    Xi Jiang; Fiscal Year: 1999
    ..HuCVs include three genogroups: Norwalk virus (NV), Sapporo and Hepatitis E genogroups. The NV genogroup can be divided further into NV-like and Snow Mountain agent (SMA)-like HuCVs...
  22. CHARACTERIZATION OF HUMAN CALICIVIRUS
    Xi Jiang; Fiscal Year: 2000
    ..HuCVs include three genogroups: Norwalk virus (NV), Sapporo and Hepatitis E genogroups. The NV genogroup can be divided further into NV-like and Snow Mountain agent (SMA)-like HuCVs...
  23. Morpholino Antisense Drugs for Hepatitis E Virus
    Yan Jin Zhang; Fiscal Year: 2010
    b>Hepatitis E virus (HEV) causes endemic and large epidemics of acute human hepatitis and sporadic cases by a fecal-oral transmission in many parts of the world...
  24. Morpholino Antisense Drugs for Hepatitis E Virus
    Yan Jin Zhang; Fiscal Year: 2009
    b>Hepatitis E virus (HEV) causes endemic and large epidemics of acute human hepatitis and sporadic cases by a fecal-oral transmission in many parts of the world...
  25. Morpholino Antisense Drugs for Hepatitis E Virus
    Yan Jin Zhang; Fiscal Year: 2010
    b>Hepatitis E virus (HEV) causes endemic and large epidemics of acute human hepatitis and sporadic cases by a fecal-oral transmission in many parts of the world...
  26. Immune events, transcriptomics and biomarkers in hepatitis E pathogenesis
    Shahid Jameel; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hepatitis E, caused by infection with waterborne hepatitis E virus (HEV) is endemic in several developing countries, particularly in Asia and Africa...
  27. Immune events, transcriptomics and biomarkers in hepatitis E pathogenesis
    Shahid Jameel; Fiscal Year: 2007
    b>Hepatitis E, caused by infection with waterborne hepatitis E virus (HEV) is endemic in several developing countries, particularly in Asia and Africa. In the Indian subcontinent, hepatitis E occurs as large outbreaks...
  28. Immune events, transcriptomics and biomarkers in hepatitis E pathogenesis
    Shahid Jameel; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Hepatitis E, caused by infection with waterborne hepatitis E virus (HEV) is endemic in several developing countries, particularly in Asia and Africa...
  29. Cell-free Replication of Hepatitis E Virus
    Naushad Ali; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Hepatitis E Virus (HEV) is a leading cause of severe acute hepatitis worldwide and numerous outbreaks in the developing countries...
  30. Cell-free Replication of Hepatitis E Virus
    Naushad Ali; Fiscal Year: 2005
    b>Hepatitis E Virus (HEV) is a leading cause of severe acute hepatitis worldwide and numerous outbreaks in the developing countries...
  31. Longitudinal cohort of newly acquired HCV infection
    John Kaldor; Fiscal Year: 2005
    ..Drug use behavior including injecting drug use will also be closely monitored, to assess the impact of enrollment into the study and specific drug dependency and risk reduction strategies. ..
  32. Longitudinal cohort of newly acquired HCV infection
    John Kaldor; Fiscal Year: 2006
    ..Drug use behavior including injecting drug use will also be closely monitored, to assess the impact of enrollment into the study and specific drug dependency and risk reduction strategies. ..
  33. Longitudinal cohort of newly acquired HCV infection
    John Kaldor; Fiscal Year: 2007
    ..Drug use behavior including injecting drug use will also be closely monitored, to assess the impact of enrollment into the study and specific drug dependency and risk reduction strategies. ..
  34. Longitudinal cohort of newly acquired HCV infection
    John Kaldor; Fiscal Year: 2004
    ..Drug use behavior including injecting drug use will also be closely monitored, to assess the impact of enrollment into the study and specific drug dependency and risk reduction strategies. ..
  35. Longitudinal cohort of newly acquired HCV infection
    John Kaldor; Fiscal Year: 2003
    ..Drug use behavior including injecting drug use will also be closely monitored, to assess the impact of enrollment into the study and specific drug dependency and risk reduction strategies. ..
  36. A Chicken Model to Study Hepatitis E Virus Pathogenesis
    Xiang Jin Meng; Fiscal Year: 2005
    b>Hepatitis E virus (HEV), the causative agent of hepatitis E, is an important public health problem in developing countries. HEV is also endemic in the U.S. The mortality rate is reportedly up to 20% in infected pregnant women...
  37. Mechanism of Hepatitis E Virus Replication and Pathogenesis
    Xiang Jin Meng; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Hepatitis E virus (HEV), the causative agent of human hepatitis E, is an important public health problem in developing countries, and is also endemic in the United States and other industrialized ..
  38. A Chicken Model to Study Hepatitis E Virus Pathogenesis
    Xiang Jin Meng; Fiscal Year: 2003
    b>Hepatitis E virus (HEV), the causative agent of hepatitis E, is an important public health problem in developing countries. HEV is also endemic in the U.S. The mortality rate is reportedly up to 20% in infected pregnant women...
  39. Animal Model Research for Veterinarians (AMRV)
    Xiang Jin Meng; Fiscal Year: 2008
    ..At the end of the training program, trainees are expected to launch an independent biomedical research career. ..
  40. A Chicken Model to Study Hepatitis E Virus Pathogenesis
    Xiang Jin Meng; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Hepatitis E virus (HEV), the causative agent of human hepatitis E, is an important public health problem in many developing countries, and is also endemic in the United States and other ..
  41. Mechanism of Hepatitis E Virus Replication and Pathogenesis
    Xiang Jin Meng; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hepatitis E virus (HEV), the causative agent of human hepatitis E, is an important public health problem in developing countries, and is also endemic in the United States and other industrialized ..
  42. Mechanism of Hepatitis E Virus Replication and Pathogenesis
    Xiang Jin Meng; Fiscal Year: 2008
    b>Hepatitis E virus (HEV), the causative agent of human hepatitis E, is an important public health problem in developing countries, and is also endemic in the United States and other industrialized countries...
  43. A Chicken Model to Study Hepatitis E Virus Pathogenesis
    Xiang Jin Meng; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hepatitis E virus (HEV), the causative agent of human hepatitis E, is an important public health problem in many developing countries, and is also endemic in the United States and other ..
  44. A Chicken Model to Study Hepatitis E Virus Pathogenesis
    Xiang Jin Meng; Fiscal Year: 2008
    b>Hepatitis E virus (HEV), the causative agent of human hepatitis E, is an important public health problem in many developing countries, and is also endemic in the United States and other industrialized countries...
  45. ZOONOTIC AND XENOZOONOTIC RISKS OF HEPATITIS E VIRUS
    Xiang Jin Meng; Fiscal Year: 2000
    ..b>Hepatitis E virus (HEV), the causative agent of hepatitis E is an important human pathogen worldwide and causes very high ..
  46. ZOONOTIC AND XENOZOONOTIC RISKS OF HEPATITIS E VIRUS
    Xiang Jin Meng; Fiscal Year: 2001
    ..b>Hepatitis E virus (HEV), the causative agent of hepatitis E is an important human pathogen worldwide and causes very high ..
  47. A Chicken Model to Study Hepatitis E Virus Pathogenesis
    Xiang Jin Meng; Fiscal Year: 2002
    b>Hepatitis E virus (HEV), the causative agent of hepatitis E, is an important public health problem in developing countries. HEV is also endemic in the U.S. The mortality rate is reportedly up to 20% in infected pregnant women...
  48. A Chicken Model to Study Hepatitis E Virus Pathogenesis
    Xiang Jin Meng; Fiscal Year: 2004
    b>Hepatitis E virus (HEV), the causative agent of hepatitis E, is an important public health problem in developing countries. HEV is also endemic in the U.S. The mortality rate is reportedly up to 20% in infected pregnant women...
  49. Animal Model Research for Veterinarians (AMRV)
    Xiang Jin Meng; Fiscal Year: 2007
    ..At the end of the training program, trainees are expected to launch an independent biomedical research career. ..
  50. Greater Sensitivity ELISA for HIV by Photoillumination
    MICHAEL MUEHLEMANN; Fiscal Year: 2001
    ..Coli, Samonella and a host of tumor markers. ..
  51. Immune events, transcriptomics and biomarkers in hepatitis E pathogenesis
    Shahid Jameel; Fiscal Year: 2008
    b>Hepatitis E, caused by infection with waterborne hepatitis E virus (HEV) is endemic in several developing countries, particularly in Asia and Africa. In the Indian subcontinent, hepatitis E occurs as large outbreaks...
  52. Towards Understanding the Morbidity of HEV Infection
    Mohamed Tarek Shata; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Hepatitis E (HEV) is enterically transmitted RNA virus that causes acute viral hepatitis (AVH) in many lesser developed countries (LDC), with frequent reports of fulminant hepatitis in ..
  53. Evaluation of the Control of HIV After a Prison Amnesty in Taiwan
    Kenrad Nelson; Fiscal Year: 2008
    ..unreadable] [unreadable] The collaboration is between the Bloomberg School of Public Health of Johns Hopkins University and the Center for Disease Control in Taiwan. [unreadable] [unreadable] [unreadable]..
  54. Epidemiology of Hep E Virus Infections in Bangladesh
    Kenrad Nelson; Fiscal Year: 2002
    b>Hepatitis E virus (HEV) infections cause serious morbidity and mortality, especially in pregnant women. Few population-based studies have characterized HEV epidemiology...
  55. Prevalence and Epidemiology of Hepatitis E Virus in the United States
    Kenrad Nelson; Fiscal Year: 2008
    b>Hepatitis E virus (HEV) is the etiologic agent responsible for large outbreaks of clinical hepatitis in developing countries and a large proportion of sporadic clinical hepatitis in developing countries...
  56. Epidemiology of Hep E Virus Infections in Bangladesh
    Kenrad Nelson; Fiscal Year: 2003
    b>Hepatitis E virus (HEV) infections cause serious morbidity and mortality, especially in pregnant women. Few population-based studies have characterized HEV epidemiology...
  57. THE EPIDEMIOLOGY OF HEPATITIS C INFECTION IN THAILAND
    Kenrad Nelson; Fiscal Year: 2004
    ..Through the transfer of technology for HCV research to our collaborators, we hope to focus on understanding the biology and epidemiology of HCV and the development of more effective prevention of HCV. ..
  58. Extrahepatic Replication and Viral Evolution of HCV During HCV/HIV Co-infection
    Jason Blackard; Fiscal Year: 2007
    ..This proposal will provide important data on co-factors of virus transmission and identify potential markers of HCV disease progression and treatment failure. [unreadable] [unreadable] [unreadable]..
  59. HCV Genotype 6: A Model for HCV Genetics and Molecular Epidemiology Studies
    Ling Lu; Fiscal Year: 2010
    ..This information and the derived models are vital for better strategies of HCV diagnosis and treatment, and the improved designs of antivirals and vaccines. ..