arenaviridae infections

Summary

Summary: Virus diseases caused by the ARENAVIRIDAE.

Top Publications

  1. ncbi Transmission of lymphocytic choriomeningitis virus by organ transplantation
    Staci A Fischer
    Rhode Island Hospital and Brown Medical School, Providence, USA
    N Engl J Med 354:2235-49. 2006
  2. pmc The major determinant of attenuation in mice of the Candid1 vaccine for Argentine hemorrhagic fever is located in the G2 glycoprotein transmembrane domain
    Cesar G Albarino
    Centers for Disease Control and Prevention, MS G14, Atlanta, GA 30329, USA
    J Virol 85:10404-8. 2011
  3. pmc The RING domain and the L79 residue of Z protein are involved in both the rescue of nucleocapsids and the incorporation of glycoproteins into infectious chimeric arenavirus-like particles
    Juan Cruz Casabona
    Centro de Virologia Animal CEVAN, Instituto de Ciencia y Tecnología Dr Cesar Milstein, Consejo Nacional de Ciencia y Tecnología CONICET, Saladillo 2468, C1440FFX Ciudad Autónoma de Buenos Aires, Argentina
    J Virol 83:7029-39. 2009
  4. pmc Rescue from cloned cDNAs and in vivo characterization of recombinant pathogenic Romero and live-attenuated Candid #1 strains of Junin virus, the causative agent of Argentine hemorrhagic fever disease
    Sebastien F Emonet
    Department of Immunology and Microbial Science IMM 6, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Virol 85:1473-83. 2011
  5. ncbi Pathogenesis of arenavirus hemorrhagic fevers
    Marie Laurence Moraz
    Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland
    Expert Rev Anti Infect Ther 9:49-59. 2011
  6. ncbi Animal models of highly pathogenic RNA viral infections: hemorrhagic fever viruses
    Brian B Gowen
    Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 78:79-90. 2008
  7. pmc Genomic and phylogenetic characterization of Merino Walk virus, a novel arenavirus isolated in South Africa
    Gustavo Palacios
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA
    J Gen Virol 91:1315-24. 2010
  8. ncbi Receptor binding and cell entry of Old World arenaviruses reveal novel aspects of virus-host interaction
    Stefan Kunz
    Institute of Microbiology, University Hospital Center and University of Lausanne, Switzerland
    Virology 387:245-9. 2009
  9. ncbi A new arenavirus in a cluster of fatal transplant-associated diseases
    Gustavo Palacios
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    N Engl J Med 358:991-8. 2008
  10. pmc Interferon-gamma acts directly on CD8+ T cells to increase their abundance during virus infection
    Jason K Whitmire
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 201:1053-9. 2005

Research Grants

Detail Information

Publications206 found, 100 shown here

  1. ncbi Transmission of lymphocytic choriomeningitis virus by organ transplantation
    Staci A Fischer
    Rhode Island Hospital and Brown Medical School, Providence, USA
    N Engl J Med 354:2235-49. 2006
    ..Each cluster was investigated because diagnostic evaluations were unrevealing, and in each a common donor was recognized...
  2. pmc The major determinant of attenuation in mice of the Candid1 vaccine for Argentine hemorrhagic fever is located in the G2 glycoprotein transmembrane domain
    Cesar G Albarino
    Centers for Disease Control and Prevention, MS G14, Atlanta, GA 30329, USA
    J Virol 85:10404-8. 2011
    ..This work provides insight into the molecular mechanisms of attenuation of the only arenavirus vaccine currently available...
  3. pmc The RING domain and the L79 residue of Z protein are involved in both the rescue of nucleocapsids and the incorporation of glycoproteins into infectious chimeric arenavirus-like particles
    Juan Cruz Casabona
    Centro de Virologia Animal CEVAN, Instituto de Ciencia y Tecnología Dr Cesar Milstein, Consejo Nacional de Ciencia y Tecnología CONICET, Saladillo 2468, C1440FFX Ciudad Autónoma de Buenos Aires, Argentina
    J Virol 83:7029-39. 2009
    ..Our results support the conclusion that the interaction between Z and N is required for assembly of both the nucleocapsids and the glycoproteins into infectious arenavirus budding particles...
  4. pmc Rescue from cloned cDNAs and in vivo characterization of recombinant pathogenic Romero and live-attenuated Candid #1 strains of Junin virus, the causative agent of Argentine hemorrhagic fever disease
    Sebastien F Emonet
    Department of Immunology and Microbial Science IMM 6, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Virol 85:1473-83. 2011
    ..In addition, we rescued Candid #1 viruses with three segments that efficiently expressed foreign genes introduced into their genomes. This finding opens the way for the development of a safe multivalent arenavirus vaccine...
  5. ncbi Pathogenesis of arenavirus hemorrhagic fevers
    Marie Laurence Moraz
    Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland
    Expert Rev Anti Infect Ther 9:49-59. 2011
    ..The scope of this article is to review our current knowledge on arenavirus VHF pathogenesis with an emphasis on recent developments...
  6. ncbi Animal models of highly pathogenic RNA viral infections: hemorrhagic fever viruses
    Brian B Gowen
    Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 78:79-90. 2008
    ..Such models are sufficient for testing of drugs that directly block viral replication, but may be inadequate for evaluating therapies that depend for their success on the activation or inhibition of host responses...
  7. pmc Genomic and phylogenetic characterization of Merino Walk virus, a novel arenavirus isolated in South Africa
    Gustavo Palacios
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA
    J Gen Virol 91:1315-24. 2010
    ..We propose MWV as a tentative novel species in the Lassa-lymphocytic choriomeningitis virus complex, based on its isolation from a novel rodent species and its genetic and serological characteristics...
  8. ncbi Receptor binding and cell entry of Old World arenaviruses reveal novel aspects of virus-host interaction
    Stefan Kunz
    Institute of Microbiology, University Hospital Center and University of Lausanne, Switzerland
    Virology 387:245-9. 2009
    ..Alternatively, engagement of arenavirus particles may target DG for an endocytotic pathway not normally used in uninfected cells thereby inducing an entry route specifically tailored to the pathogen's needs...
  9. ncbi A new arenavirus in a cluster of fatal transplant-associated diseases
    Gustavo Palacios
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    N Engl J Med 358:991-8. 2008
    ..Culture, polymerase-chain-reaction (PCR) and serologic assays, and oligonucleotide microarray analysis for a wide range of infectious agents were not informative...
  10. pmc Interferon-gamma acts directly on CD8+ T cells to increase their abundance during virus infection
    Jason K Whitmire
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 201:1053-9. 2005
    ..The stimulatory effect is abrogated in T cells lacking the IFNgamma receptor, indicating that the cytokine acts directly upon CD8(+) T cells to increase their abundance during acute viral infection...
  11. pmc Early and strong immune responses are associated with control of viral replication and recovery in lassa virus-infected cynomolgus monkeys
    Sylvain Baize
    Unité de Biologie des Infections Virales Emergentes, Institut Pasteur IFR 128 BioSciences Gerland Lyon Sud, Lyon, France
    J Virol 83:5890-903. 2009
    ....
  12. pmc In vitro and in vivo activities of T-705 against arenavirus and bunyavirus infections
    Brian B Gowen
    Institute for Antiviral Research, Utah State University, Logan, UT 84322, USA
    Antimicrob Agents Chemother 51:3168-76. 2007
    ..Our results suggest that T-705 may be a viable alternative for the treatment of life-threatening bunyaviral and arenaviral infections...
  13. pmc The curious case of arenavirus entry, and its inhibition
    Jack H Nunberg
    Montana Biotechnology Center, The University of Montana, Missoula, MT 59812, USA
    Viruses 4:83-101. 2012
    ..This unusual solution to maintaining the metastable prefusion state of GPC on the virion and activating the class I fusion cascade at acidic pH provides novel targets for antiviral intervention...
  14. ncbi The role of the vascular endothelium in arenavirus haemorrhagic fevers
    Stefan Kunz
    Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland
    Thromb Haemost 102:1024-9. 2009
    ..These studies provided first possible links to some of the vascular abnormalities observed in patients, however, their relevance in vivo remains to be investigated...
  15. pmc Treatment of late stage disease in a model of arenaviral hemorrhagic fever: T-705 efficacy and reduced toxicity suggests an alternative to ribavirin
    Brian B Gowen
    Institute for Antiviral Research, Logan, UT, USA
    PLoS ONE 3:e3725. 2008
    ..Our findings support further pre-clinical development of T-705 for the treatment of severe arenaviral infections...
  16. ncbi Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection
    Khuong B Nguyen
    Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    Science 297:2063-6. 2002
    ..Thus, type 1 IFNs, in addition to interleukin-12, provide pathways for innate regulation of adaptive immunity, and their immunoregulatory functions are controlled by modulating the activity of individual STATs...
  17. pmc Novel arenavirus, Zambia
    Akihiro Ishii
    Hokkaido University, Sapporo, Japan
    Emerg Infect Dis 17:1921-4. 2011
    ..Full-genome sequences of the viruses suggested that they were new strains similar to Lassa virus-related arenaviruses. Analyzing samples from additional rodents and other species can elucidate epizootiologic aspects of arenaviruses...
  18. pmc Mice lacking alpha/beta and gamma interferon receptors are susceptible to junin virus infection
    Olga A Kolokoltsova
    Galveston National Laboratory, Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1019, USA
    J Virol 84:13063-7. 2010
    ..After peripheral inoculation with virulent JUNV, adult mice lacking alpha/beta and gamma interferon receptors developed disseminated infection and severe disease...
  19. ncbi Hemorrhagic fever viruses as biological weapons: medical and public health management
    Luciana Borio
    Johns Hopkins Center for Civilian Biodefense Strategies, Johns Hopkins Schools of Medicine and Public Health, 111 Market Pl, Suite 830, Baltimore, MD 21202, USA
    JAMA 287:2391-405. 2002
    ..To develop consensus-based recommendations for measures to be taken by medical and public health professionals if hemorrhagic fever viruses (HFVs) are used as biological weapons against a civilian population...
  20. pmc Receptor determinants of zoonotic transmission of New World hemorrhagic fever arenaviruses
    Sheli R Radoshitzky
    Department of Microbiology and Molecular Genetics and New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
    Proc Natl Acad Sci U S A 105:2664-9. 2008
    ....
  21. ncbi Identification and characterization of potent small molecule inhibitor of hemorrhagic fever New World arenaviruses
    Tove C Bolken
    SIGA Technologies Inc, 4575 SW Research Way, Corvallis, OR 97333, USA
    Antiviral Res 69:86-97. 2006
    ..This series of compounds represent a new class of inhibitors that may warrant further development for potential inclusion in a strategic stockpile...
  22. pmc Nosocomial outbreak of novel arenavirus infection, southern Africa
    Janusz T Paweska
    National Institute for Communicable Diseases, Sandringham, South Africa
    Emerg Infect Dis 15:1598-602. 2009
    ..Three cases involved secondary spread of infection from the first patient, and 1 was a tertiary infection. A novel arenavirus was identified. The source of the first patient's infection remains undetermined...
  23. ncbi Zoonotic aspects of arenavirus infections
    R N Charrel
    Unite des Virus Emergents, UMR190 Emergence des pathologies virales Université de Méditerranée, Institut de Recherche pour Développement, Faculte de Medecine, Marseille, France
    Vet Microbiol 140:213-20. 2010
    ..The approach based on consensus degenerate primers has shown efficient for both detection of known arenaviruses, and discovery of new arenaviruses...
  24. pmc Alterations in NF-kappaB and RBP-Jkappa by arenavirus infection of macrophages in vitro and in vivo
    S M Fennewald
    Department of Pathology and WHO Collaborating Center for Tropical Disease, University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
    J Virol 76:1154-62. 2002
    ..Taken together, these changes suggest that the attenuated viral strain induces an "activation" of macrophages, while the virulent form of the virus does not...
  25. pmc LCMV-mediated hepatitis in rhesus macaques: WE but not ARM strain activates hepatocytes and induces liver regeneration
    I S Lukashevich
    Biotechnology Center, Institute of Human Virology, University of Maryland, Baltimore, Maryland 21201, USA
    Arch Virol 149:2319-36. 2004
    ..Previously we demonstrated that LCMV-ARM infection protected rhesus macaques challenged with LCMV-WE. Here we have shown that the protected animals have no signs of hepatitis and hepatocyte proliferation...
  26. pmc Junín virus infection activates the type I interferon pathway in a RIG-I-dependent manner
    Cheng Huang
    Galveston National Laboratory, Department of Pathology and Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, USA
    PLoS Negl Trop Dis 6:e1659. 2012
    ....
  27. pmc FOXO3 regulates CD8 T cell memory by T cell-intrinsic mechanisms
    Jeremy A Sullivan
    Department of Pathobiological Sciences, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS Pathog 8:e1002533. 2012
    ..In summary, we have identified FOXO3 as a critical regulator of CD8 T cell memory, and therapeutic modulation of FOXO3 might enhance vaccine-induced protective immunity against intracellular pathogens...
  28. pmc Cross-species analysis of the replication complex of Old World arenaviruses reveals two nucleoprotein sites involved in L protein function
    Romy Kerber
    Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    J Virol 85:12518-28. 2011
    ..Residue 53 and the C-terminal domain of NP are important for function of L protein during genome replication and transcription...
  29. pmc Severe hemorrhagic fever in strain 13/N guinea pigs infected with Lujo virus
    Brian H Bird
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Negl Trop Dis 6:e1801. 2012
    ..Establishing an animal LUJV model is an important first step towards understanding the high pathogenicity of LUJV and developing vaccines and antiviral therapeutic drugs for this highly transmissible and lethal emerging pathogen...
  30. pmc Progress in the experimental therapy of severe arenaviral infections
    Brian B Gowen
    Institute for Antiviral Research and Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA
    Future Microbiol 6:1429-41. 2011
    ..In this paper, we review current developments in the experimental therapy of severe arenaviral infections, focusing on drugs that have been tested in animal models, and provide a perspective on future research...
  31. pmc Junín virus infection of human hematopoietic progenitors impairs in vitro proplatelet formation and platelet release via a bystander effect involving type I IFN signaling
    Roberto G Pozner
    Department of Thrombosis and Hemostasis, Hematological Research Institute Mariano R Castex, National Academy of Medicine, CONICET, Buenos Aires, Argentina
    PLoS Pathog 6:e1000847. 2010
    ..Our study introduces a potential mechanism for thrombocytopenia in VHF and other diseases associated with increased bone marrow type I IFN levels...
  32. pmc Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection
    Sang Jun Ha
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 205:543-55. 2008
    ..Such an approach may have broad applications in developing treatment strategies for chronic infections in general, and perhaps also for tumors...
  33. pmc Development of peptide-conjugated morpholino oligomers as pan-arenavirus inhibitors
    Benjamin W Neuman
    University of Reading, Reading RG6 6AJ, United Kingdom
    Antimicrob Agents Chemother 55:4631-8. 2011
    ..These results suggest that arenavirus 5' genomic termini represent promising targets for pan-arenavirus antiviral therapeutic development...
  34. ncbi Arenaviruses and hantaviruses: from epidemiology and genomics to antivirals
    R N Charrel
    Unité des Virus Emergents UMR190, Universite de la Mediterranee, Marseille, France
    Antiviral Res 90:102-14. 2011
    ....
  35. ncbi Genistein, a general kinase inhibitor, as a potential antiviral for arenaviral hemorrhagic fever as described in the Pirital virus-Syrian golden hamster model
    Eric M Vela
    Battelle Memorial Institute, 505 King Avenue, Columbus, OH 43201, USA
    Antiviral Res 87:318-28. 2010
    ..In all, the results from this study demonstrate the potential of a general kinase inhibitor genistein as an antiviral against arenaviral hemorrhagic fever...
  36. pmc Identification of differentially activated cell-signaling networks associated with pichinde virus pathogenesis by using systems kinomics
    Gavin C Bowick
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Virol 81:1923-33. 2007
    ..We believe that these nodes provide potential targets for the development of antiviral therapies by acting at the level of the host response rather than by directly targeting viral proteins...
  37. ncbi Molecular and cell biology of the prototypic arenavirus LCMV: implications for understanding and combating hemorrhagic fever arenaviruses
    Juan C de la Torre
    Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA
    Ann N Y Acad Sci 1171:E57-64. 2009
    ..This, in turn, should facilitate the development of novel both vaccines and antiviral drugs to combat the dual threats of naturally occurring and intentionally introduced arenavirus infections...
  38. pmc Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection
    Ganesh A Kolumam
    Department of Immunology, University of Washington, Seattle, 98195, USA
    J Exp Med 202:637-50. 2005
    ..Thus, IFN-IR signaling in CD8 T cells is critical for the generation of effector and memory cells in response to viral infection...
  39. pmc An antibody directed against the fusion peptide of Junin virus envelope glycoprotein GPC inhibits pH-induced membrane fusion
    Joanne York
    Montana Biotechnology Center, Science Complex Room 221, The University of Montana, Missoula, MT 59812, USA
    J Virol 84:6119-29. 2010
    ..Binding to the transiently exposed fusion peptide may interfere with G2 insertion into the host cell membrane. Strategies to effectively target fusion peptide function in the endosome may lead to novel classes of antiviral agents...
  40. pmc Lassa and Mopeia virus replication in human monocytes/macrophages and in endothelial cells: different effects on IL-8 and TNF-alpha gene expression
    I S Lukashevich
    Department of Pathology, University of Wisconsin, Madison, Wisconsin, USA
    J Med Virol 59:552-60. 1999
    ..The cumulative down-regulation of TNF-alpha and IL-8 expression could explain the absence of inflammatory and effective immune responses in severe cases of Lassa HF...
  41. pmc Unusual molecular architecture of the machupo virus attachment glycoprotein
    Thomas A Bowden
    University of Oxford, United Kingdom
    J Virol 83:8259-65. 2009
    ..This provides a blueprint of the New World arenavirus attachment glycoproteins and reveals a new architecture of viral attachment, using a protein fold of unknown origins...
  42. ncbi Deliberate removal of T cell help improves virus-neutralizing antibody production
    Mike Recher
    Institute for Experimental Immunology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Nat Immunol 5:934-42. 2004
    ..These unexpected consequences of polyclonal B cell activation may affect vaccine strategies and the treatment of clinically relevant chronic bacterial, parasitic and viral infections in which hypergammaglobulinemia is regularly found...
  43. pmc Analysis of the differential host cell nuclear proteome induced by attenuated and virulent hemorrhagic arenavirus infection
    Gavin C Bowick
    Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, USA
    J Virol 83:687-700. 2009
    ..This study provides a number of differentially expressed targets for further research and suggests that key events in pathogenesis may be established early in infection...
  44. ncbi Endothelial cell function alteration after Junin virus infection
    Ricardo Martin Gomez
    Department of Microbiology, Faculty of Medicine, University of Buenos Aires, CONICET, Argentina
    Thromb Haemost 90:326-33. 2003
    ..These data demonstrate that endothelial cell responses are triggered subsequently by JV infection, suggesting that such alterations play a major role in the pathogenesis of AHF and perhaps in other viral-induced hemorrhagic diseases...
  45. pmc Mucosal arenavirus infection of primates can protect them from lethal hemorrhagic fever
    Juan D Rodas
    Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21201, USA
    J Med Virol 72:424-35. 2004
    ..Cross protection between the two strains was observed. The three out of seven monkeys that experienced protection were also the three with the strongest cell-mediated immunity...
  46. pmc Lymphocytic choriomeningitis virus (LCMV) infection of macaques: a model for Lassa fever
    Juan C Zapata
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, United States
    Antiviral Res 92:125-38. 2011
    ..By monitoring system-wide changes in physiology and gene expression in a controlled experimental setting, it is possible to identify events that are pathognomonic for developing VHF and potential treatment targets...
  47. pmc Genetic evidence for a tacaribe serocomplex virus, Mexico
    Catherine C Inizan
    University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
    Emerg Infect Dis 16:1007-10. 2010
    ..Analyses of nucleotide and amino acid sequence data indicated that the woodrats were infected with a novel Tacaribe serocomplex virus, proposed name Real de Catorce virus...
  48. ncbi Thioaptamer decoy targeting of AP-1 proteins influences cytokine expression and the outcome of arenavirus infections
    Susan M Fennewald
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    J Gen Virol 88:981-90. 2007
    ..These data demonstrate a proof of concept that thioaptamers can be used to modulate the outcome of in vivo viral infections by arenaviruses by the manipulation of transcription factors involved in the regulation of the immune response...
  49. pmc A STAT-1 knockout mouse model for Machupo virus pathogenesis
    Steven B Bradfute
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
    Virol J 8:300. 2011
    ..This is due, in part, to a paucity of small animal models for MACV infection in which to discover and explore candidate therapeutics...
  50. pmc MyD88 intrinsically regulates CD4 T-cell responses
    Shenghua Zhou
    Department of Medicine, University of Massachusetts Medical Center, Worcester, 01605, USA
    J Virol 83:1625-34. 2009
    ....
  51. ncbi Clinical laboratory, virologic, and pathologic changes in hamsters experimentally infected with Pirital virus (Arenaviridae): a rodent model of Lassa fever
    Elena Sbrana
    Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, 77555 0609, USA
    Am J Trop Med Hyg 74:1096-102. 2006
    ....
  52. ncbi Characterization of Junín virus particles inactivated by a zinc finger-reactive compound
    Cybele C García
    Laboratorio de Virologia, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon 2, Piso 4, 1428 Buenos Aires, Argentina
    Virus Res 143:106-13. 2009
    ....
  53. ncbi Recombination of retrotransposon and exogenous RNA virus results in nonretroviral cDNA integration
    Markus B Geuking
    Institute of Experimental Immunology, University Hospital Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland
    Science 323:393-6. 2009
    ..Thus, RNA viruses should be closely scrutinized for any capacity to interact with endogenous retroviral elements before their approval for therapeutic use in humans...
  54. ncbi Catarina virus, an arenaviral species principally associated with Neotoma micropus (southern plains woodrat) in Texas
    Maria N B Cajimat
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
    Am J Trop Med Hyg 77:732-6. 2007
    ....
  55. pmc Transferrin receptor 1 in the zoonosis and pathogenesis of New World hemorrhagic fever arenaviruses
    Hyeryun Choe
    Department of Medicine, Children s Hospital, Harvard Medical School, Boston, MA, USA
    Curr Opin Microbiol 14:476-82. 2011
    ..TfR1 is upregulated as a result of iron sequestration during the acute-phase response to infection, and the severity of disease may result from amplification of viral replication during this response...
  56. pmc Coverage of related pathogenic species by multivalent and cross-protective vaccine design: arenaviruses as a model system
    Jason Botten
    Department of Medicine, The University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, Vermont 05405 00681, USA
    Microbiol Mol Biol Rev 74:157-70. 2010
    ..This review summarizes the findings from our studies and discusses their application to future vaccine design...
  57. pmc IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection
    David G Brooks
    Viral Immunobiology Laboratory, Department of Molecular and Integrative Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 205:533-41. 2008
    ..Consequently, blocking key suppressive factors could render ineffective vaccines more efficient at improving T cell immunity, and thereby allow immune-mediated control of persistent viral infection...
  58. pmc Diversity among Tacaribe serocomplex viruses (family Arenaviridae) naturally associated with the Mexican woodrat (Neotoma mexicana)
    Maria N B Cajimat
    Microbiology and Immunology Graduate Program, Graduate School of Biomedical Sciences, University of Texas Medical Branch, Galveston, TX 77555 1019, USA
    Virus Res 133:211-7. 2008
    ..Conceptually, the viruses from Colorado, New Mexico, and Utah and strain AV 9310135 could be grouped together in a species complex in the family Arenaviridae, genus Arenavirus...
  59. pmc Use of recombinant adenovirus vectored consensus IFN-α to avert severe arenavirus infection
    Brian B Gowen
    Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, United States of America
    PLoS ONE 6:e26072. 2011
    ..The DEF201 technology has the potential to address all of these issues and may serve as a broad-spectrum antiviral to enhance host defense against a number of viral pathogens...
  60. ncbi Evaluating the immunogenicity and protective efficacy of a DNA vaccine encoding Lassa virus nucleoprotein
    Maria P Rodriguez-Carreno
    Department of Neuropharmacology, CVN 9, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Virology 335:87-98. 2005
    ..A DNA minigene vaccine encoding a 9 amino acid sequence from LNP also induces CD8(+) T cells and protects against arenavirus challenge, thus confirming prior speculation that protective cellular immunity is induced by LV proteins...
  61. ncbi Inhibition of Junín virus replication by small interfering RNAs
    María C Artuso
    Laboratory of Virology, Department of Biological Chemistry, School of Sciences, University of Buenos Aires, Ciudad Universitaria, Pabellon 2, Piso 4, 1428 Buenos Aires, Argentina
    Antiviral Res 84:31-7. 2009
    ..Thus, the present study represents the first report of virus inhibition mediated by RNA interference for a New World arenavirus...
  62. ncbi Junin virus vaccines
    D A Enria
    Instituto Nacional de Enfermedades Virales Humanas INEVH, Dr Julio I Maiztegui, Monteagudo 2510, 2700 Pergamino, Argentina
    Curr Top Microbiol Immunol 263:239-61. 2002
  63. pmc Effects of promyelocytic leukemia protein on virus-host balance
    Weldy V Bonilla
    Institute of Experimental Immunology, University Hospital, CH 8091 Zurich, Switzerland
    J Virol 76:3810-8. 2002
    ..These in vivo observations corroborated our results showing more virus production in PML(-/-) fibroblasts. Thus, PML is a contributor to innate immunity, defining host susceptibility to viral infections and to immunopathology...
  64. pmc Tacaribe virus but not junin virus infection induces cytokine release from primary human monocytes and macrophages
    Allison Groseth
    Institut fur Virologie, Philipps Universitat Marburg, Marburg, Germany
    PLoS Negl Trop Dis 5:e1137. 2011
    ....
  65. pmc Molecular analysis of the interaction of LCMV with its cellular receptor [alpha]-dystroglycan
    S Kunz
    The Scripps Research Institute, Division of Virology, Department of Neuropharmacology, La Jolla, CA 92037, USA
    J Cell Biol 155:301-10. 2001
    ..Infection followed by dysfunction of these antigen-presenting cells contributes to immunosuppression and persistent viral infection in vivo...
  66. ncbi Arenaviruses other than Lassa virus
    Remi N Charrel
    Unite des Virus Emergents, EA 3292, IRD UR 034, IFR 48, Faculte de Medecine, 27 Boulevard Jean Moulin, Marseille 13005, France
    Antiviral Res 57:89-100. 2003
    ....
  67. ncbi Hypergammaglobulinemia and autoantibody induction mechanisms in viral infections
    Lukas Hunziker
    Institute for Experimental Immunology, University Hospital, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Nat Immunol 4:343-9. 2003
    ..This nonspecific B cell activation may contribute to antibody-mediated autoimmunity...
  68. pmc Genetic detection and characterization of Lujo virus, a new hemorrhagic fever-associated arenavirus from southern Africa
    Thomas Briese
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA
    PLoS Pathog 5:e1000455. 2009
    ..LUJV is a novel, genetically distinct, highly pathogenic arenavirus...
  69. pmc Gene expression in primate liver during viral hemorrhagic fever
    Mahmoud Djavani
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Virol J 6:20. 2009
    ..In the present study, changes in liver gene expression from macaques infected with virulent LCMV-WE were compared to gene expression in uninfected monkeys as well as to monkeys that were infected but not diseased...
  70. ncbi Regulation of homeostatic chemokine expression and cell trafficking during immune responses
    Scott N Mueller
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Science 317:670-4. 2007
    ..We propose that this transient chemokine modulation may help orchestrate local cellularity, thus minimizing competition for space and resources in activated lymphoid tissues...
  71. pmc Antigen-independent memory CD8 T cells do not develop during chronic viral infection
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Room G211, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 101:16004-9. 2004
    ..These findings raise concerns about using vaccines that may persist and also suggest that there may be limitations and challenges in designing effective immunological interventions for the treatment of chronic infections and tumors...
  72. pmc Attenuated and lethal variants of Pichindé virus induce differential patterns of NF-kappaB activation suggesting a potential target for novel therapeutics
    Gavin C Bowick
    Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
    Viral Immunol 22:457-62. 2009
    ..Here we further define the potential mechanism for NF-kappaB inhibition as involving increased levels of repressive p50/p50 homodimers, and suggest a novel therapeutic strategy that acts via modulation of host signaling...
  73. pmc Differential signaling networks induced by mild and lethal hemorrhagic fever virus infections
    Gavin C Bowick
    University of Texas Medical Branch, 201 University Blvd, Galveston, TX 77555, USA
    J Virol 80:10248-52. 2006
    ..By analyzing protein level changes using pathway analysis, we have identified key intermediates which may be targets for therapeutic intervention...
  74. pmc Evaluation of the anti-arenaviral activity of the subtilisin kexin isozyme-1/site-1 protease inhibitor PF-429242
    Antonella Pasquato
    Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland
    Virology 423:14-22. 2012
    ..Notably, PF-429242 was able to efficiently and rapidly clear persistent infection by arenaviruses. Interruption of drug treatment did not result in re-emergence of infection, indicating that PF-429242 treatment leads to virus extinction...
  75. pmc Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner
    Daniel L Popkin
    Department of Immunology and Microbial Sciences, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Host Microbe 9:212-22. 2011
    ..These results support in vivo targeting of Mbtps1 in the treatment of arenavirus infections and demonstrate a critical role for dendritic cells in persistent viral infections...
  76. ncbi RT-PCR assay for detection of Lassa virus and related Old World arenaviruses targeting the L gene
    Simon Vieth
    Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359 Hamburg, Germany
    Trans R Soc Trop Med Hyg 101:1253-64. 2007
    ....
  77. pmc A specific interaction of small molecule entry inhibitors with the envelope glycoprotein complex of the Junín hemorrhagic fever arenavirus
    Celestine J Thomas
    Center for Biomolecular Structure and Dynamics, University of Montana, Missoula, Montana 59812, USA
    J Biol Chem 286:6192-200. 2011
    ..This work expands our mechanistic understanding of arenavirus entry and provides a foundation to guide the development of small molecule compounds for the treatment of arenavirus hemorrhagic fevers...
  78. pmc Arenavirus-mediated liver pathology: acute lymphocytic choriomeningitis virus infection of rhesus macaques is characterized by high-level interleukin-6 expression and hepatocyte proliferation
    Igor S Lukashevich
    Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21201, USA
    J Virol 77:1727-37. 2003
    ..Our data confirm that acute infection is associated with weak inflammatory responses in tissues and initiates a program of liver regeneration in primates...
  79. pmc Development of replication-defective lymphocytic choriomeningitis virus vectors for the induction of potent CD8+ T cell immunity
    Lukas Flatz
    Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
    Nat Med 16:339-45. 2010
    ..These features, together with low seroprevalence in humans, suggest that rLCMV may show utility as a vaccine platform against infectious diseases and cancer...
  80. pmc Sympatric occurrence of 3 arenaviruses, Tanzania
    Joelle Gouy de Bellocq
    Evolutionary Ecology Group, University of Antwerp, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
    Emerg Infect Dis 16:692-5. 2010
    ..We found that 2 rodent species other than Mastomys natalensis mice carry arenaviruses. Analysis of 340 nt of the viral RNA polymerase gene showed sympatric occurrence of 3 distinct arenaviruses...
  81. ncbi Human infection with arenaviruses in the Americas
    C J Peters
    University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0609, USA
    Curr Top Microbiol Immunol 262:65-74. 2002
  82. ncbi Mammalian reservoirs of arenaviruses
    J Salazar-Bravo
    Department of Biology, Museum of Southwestern Biology, University of New Mexico, Albuquerque, NM 87131, USA
    Curr Top Microbiol Immunol 262:25-63. 2002
  83. pmc Cells expressing the RING finger Z protein are resistant to arenavirus infection
    Tatjana I Cornu
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 78:2979-83. 2004
    ..These findings open new avenues for developing antiviral strategies to combat the highly pathogenic human arenaviruses, including LFV...
  84. pmc An antiviral disulfide compound blocks interaction between arenavirus Z protein and cellular promyelocytic leukemia protein
    C C Garcia
    Laboratory of Virology, Department of Biological Chemistry, School of Sciences, University of Buenos Aires, 1428 Buenos Aires, Argentina
    Biochem Biophys Res Commun 393:625-30. 2010
    ..Altogether, these results show that the compound NSC20625 suppressed Z-mediated PML NB disruption and may be used as a tool for designing novel antiviral strategies against arenavirus infection...
  85. pmc Reverse genetics generation of chimeric infectious Junin/Lassa virus is dependent on interaction of homologous glycoprotein stable signal peptide and G2 cytoplasmic domains
    Cesar G Albarino
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G 14, Atlanta, GA 30329, USA
    J Virol 85:112-22. 2011
    ..These recombinant chimeric viruses shed light on the fundamental requirements of arenavirus GPC maturation and may serve as a strategy for the development of bivalent JUNV and LASV vaccine candidates...
  86. ncbi Cytokine patterns in a comparative model of arenavirus haemorrhagic fever in guinea pigs
    Erin P Scott
    Department of Pathology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0747, USA
    J Gen Virol 89:2569-79. 2008
    ..Suppression rather than overexpression of pro-inflammatory cytokines accompanied the terminal shock in this model of arenavirus haemorrhagic fever...
  87. ncbi Synthesis and evaluation of N-substituted acridones as antiviral agents against haemorrhagic fever viruses
    Claudia S Sepúlveda
    Laboratorio de Virologia, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina
    Antivir Chem Chemother 19:41-7. 2008
    ..In the present study, a series of N-substituted acridone derivatives was synthesized and evaluated against two haemorrhagic fever viruses (HFV)...
  88. pmc Unique small molecule entry inhibitors of hemorrhagic fever arenaviruses
    Andrew M Lee
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 283:18734-42. 2008
    ....
  89. pmc RNA interference-mediated virus clearance from cells both acutely and chronically infected with the prototypic arenavirus lymphocytic choriomeningitis virus
    Ana B Sanchez
    Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 79:11071-81. 2005
    ....
  90. ncbi Arenaviruses
    J P Gonzalez
    IRD U178, Conditions et Territoires d Emergence des Maladies, Thaïlande, France
    Curr Top Microbiol Immunol 315:253-88. 2007
    ..The diversity among rodent host reservoir and virus species and the potential to exchange genomic material provide a basis for the emergence of new viruses and the risk of these becoming pathogenic for humans...
  91. pmc The CD8+ T-cell response to lymphocytic choriomeningitis virus involves the L antigen: uncovering new tricks for an old virus
    Maya F Kotturi
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    J Virol 81:4928-40. 2007
    ..Taken together, these findings illustrate that the LCMV-specific CD8(+) T-cell response is more complex than previously appreciated...
  92. ncbi Genetic identification of Kodoko virus, a novel arenavirus of the African pigmy mouse (Mus Nannomys minutoides) in West Africa
    E Lecompte
    Institute of Virology, Philipps University, Hans Meerweinstrasse, 35 043 Marburg, Germany
    Virology 364:178-83. 2007
    ..The finding of an Old World arenavirus related to LCMV outside the known geographical range of LCMV in a novel rodent species reveals new insights about the evolutionary history of arenaviruses...
  93. ncbi Arenavirus extinction through lethal mutagenesis
    Juan Carlos de la Torre
    Department of Neuropharmacology IMM 6, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Virus Res 107:207-14. 2005
    ..These findings indicate that, as with other riboviruses, lethal mutagenesis is effective also against LCMV raising the possibility of using this novel antiviral strategy to combat pathogenic arenaviruses...
  94. ncbi Experimental infection of Neotoma albigula (Muridae) with Whitewater Arroyo virus (Arenaviridae)
    C F Fulhorst
    Department of Pathology and World Health Organization Collaborating Center for Tropical Diseases, University of Texas Medical Branch, Galveston 77555 0609, USA
    Am J Trop Med Hyg 65:147-51. 2001
    ..These results indicate that the duration of WWA virus infection in N. albigula is dependent upon the animal's age at the onset of infection and that neonatal infection can result in chronic (perhaps lifelong) virus shedding...
  95. ncbi Genomic features of attenuated Junín virus vaccine strain candidate
    Sandra Elizabeth Goñi
    LIGBCM, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Rogue Saenz Peña 180, B1876BXD, Bernal, Buenos Aires, Argentina
    Virus Genes 32:37-41. 2006
    ..These changes could be provisionally associated with the attenuated phenotype. In contrast, Z ORF was completely conserved among all strains...
  96. pmc Targeting Schwann cells by nonlytic arenaviral infection selectively inhibits myelination
    Anura Rambukkana
    Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, NY10021, USA
    Proc Natl Acad Sci U S A 100:16071-6. 2003
    ....
  97. ncbi Is there an association of Pneumocystis infection with the presence of arena-, hanta-, and poxvirus antibodies in wild mice and shrews in Finland?
    J Laakkonen
    Department of Virology, Haartman Institute, P O Box 21, FIN 00014 University of Helsinki, Finland
    Parasitology 132:461-6. 2006
    ..Concurrent presence of virus antibodies (LCMV) and cyst forms of Pneumocystis were detected only in 1 M. minutus. In conclusion, we found no evidence of any association between Pneumocystis and antibodies to any of the viruses tested...
  98. ncbi Arenavirus antibody in rodents indigenous to coastal southern California
    S G Bennett
    Orange County Vector Control District, Garden Grove, California 92843, USA
    Am J Trop Med Hyg 62:626-30. 2000
    ....
  99. ncbi Clinical case definitions for Argentine hemorrhagic fever
    L H Harrison
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pennsylvania 15261, USA
    Clin Infect Dis 28:1091-4. 1999
    ....
  100. ncbi Lymphocytic choriomeningitis virus: emerging fetal teratogen
    Leslie L Barton
    Department of Pediatrics and Steele Memorial Children s Research Center, University of Arizona, Tucson 85724, USA
    Am J Obstet Gynecol 187:1715-6. 2002
    ..We strongly suggest that obstetricians counsel their pregnant patients regarding the potential hazard that contact with infected pet, laboratory, and household mice and hamsters poses to pregnant women and their unborn children...
  101. ncbi CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors
    Loui T Madakamutil
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Science 304:590-3. 2004
    ..Thus, memory precursors can be identified among primary effector cells and are selected for survival and differentiation by CD8alphaalpha...

Research Grants54

  1. Recombinant life attenuated vaccine against Argentine hemorrhagic fever
    Slobodan Paessler; Fiscal Year: 2013
    ..We propose a novel system for vaccine production against hemorrhagic fever viruses in order to increase our ability to prevent some of the most severe infectious diseases should it be introduced into the USA. ..
  2. Novel Screen to Identify Arenavirus Inhibitors
    Juan Lama; Fiscal Year: 2013
    ..These studies may lead to the development of much needed antivirals for the treatment of highly pathogenic arenavirus infections. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page ..
  3. Targeting the processing of the arenavirus glycoprotein for anti-viral therapy.
    Juan C de la Torre; Fiscal Year: 2012
    ....
  4. A Lassa Vaccine in primates with AIDS
    Maria Salvato; Fiscal Year: 2009
    ..This is an important question since the Lassa endemic region of West Africa also has a high incidence of AIDS. ..
  5. Broad Spectrum Treatment of Hemmorrhagic Arenaviruses
    Philip E Thorpe; Fiscal Year: 2010
    ..These studies will promote further development of anti-PS antibodies for the treatment of human hemorrhagic arenavirus infections. ..
  6. MUCOSAL INFECTION WITH ARENAVIRUS
    Igor Lukashevich; Fiscal Year: 2000
    ..Thus, this information will serve as the basis for developing mucosal vaccines and pharmacological treatments that target mucosal arenavirus infections. ..
  7. Biology of Animal Nuclear Mononegaviruses
    JUAN DE LA TORRE; Fiscal Year: 2008
    ..abstract_text> ..
  8. Novel Antiviral Strategy to Combat Arenaviruses
    JUAN DE LA TORRE; Fiscal Year: 2004
    ..abstract_text> ..
  9. Identification of Borna Disease Virus Receptor Proteins
    JUAN DE LA TORRE; Fiscal Year: 2006
    ..G*/p56; 3) Determination of expression pattern of BDV candidate receptors in vivo. ..
  10. Anti-interferon Activity of the Arenavirus Nucleoprotein
    JUAN DE LA TORRE; Fiscal Year: 2008
    ..abstract_text> ..
  11. Immune cell dynamics during central nervous system viral infection
    Juan C de la Torre; Fiscal Year: 2010
    ..abstract_text> ..
  12. REVERSE GENETICS OF ARENAVIRUSES
    JUAN DE LA TORRE; Fiscal Year: 2007
    ..We will use biochemical, genetics and functional assays to assess the relevance in Arenavirus biology of candidates initially identified by TAP/MS. ..
  13. Neuroimmunologic Disorders Induced by Chronic Viral Infection
    JUAN DE LA TORRE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  14. MOLECULAR BIOLOGY OF BORNA DISEASE VIRUS (BDV)
    JUAN DE LA TORRE; Fiscal Year: 2004
    ..Conditions required for reconstitution of BDV transcription and RNA replication by intracellular coexpression of BDV minigenome and BDV proteins from separated plasmids will be determined. ..
  15. Aminoglycoside Antivirals to Combat Arenaviruses
    JUAN DE LA TORRE; Fiscal Year: 2004
    ..Emergence of resistant variants will be assessed based on production of infectious virus and intracellular levels of virus RNA synthesis during serial passages in the presence of aminoglycosides with anti-LCMV activity. ..
  16. MEASLES VIRUS STUDIES IN A TRANSGENIC MODEL
    Michael Oldstone; Fiscal Year: 2007
    ..abstract_text> ..
  17. Viruses and Diabetes
    Michael Oldstone; Fiscal Year: 2005
    ....
  18. Aging Disease--Prion/Transgenic/Immunologic Studies
    Michael Oldstone; Fiscal Year: 2008
    ..Lastly, Jose Criado will continue his electrophysiology and behavioral studies on the normal function of PrP and on its aberrations during TSE disease. ..
  19. Arenavirus Receptor-Structure/Function Studies
    Michael B Oldstone; Fiscal Year: 2010
    ..These findings have relevance for biodefense of several viruses including LFV. ..
  20. VIRUSES AND AUTOIMMUNE DISEASE
    Michael Oldstone; Fiscal Year: 2001
    ..The second order of business is to determine the role of "self" (islet-cell) antigens other than the initial triggering viral antigen in the pathogenetic process leading to and determine their role in IDDM. ..
  21. Therapeutics to Prevent/Treat Lassa Fever Virus
    Michael B Oldstone; Fiscal Year: 2010
    ..We anticipate making a significant contribution to drug development to treat these BSL-4 agents. ..
  22. Pathogenesis Studies in Scrapie (TSE Diseases)
    Michael Oldstone; Fiscal Year: 2003
    ..This model should be useful to study pathophysiology of CWD as well as probing CWD strain differences. ..
  23. STUDIES OF A NEW MYELIN GENE THAT CAUSES CNS DISEASE
    Michael Oldstone; Fiscal Year: 2001
    ..Their studies in rodents combined with those of their collaborator, Dr. Martin, should begin to characterize the role played by MONP in neurologic disease. ..
  24. Viral determinants of hantavirus pulmonary disease in the hamster
    Charles F Fulhorst; Fiscal Year: 2010
    ..The plasmid-based genetic system could be used in future studies to develop vaccines to prevent infection or disease and to (in the face of clinical disease) mitigate the severity of HPS. ..
  25. Rapid, accurate diagnostics for arenaviral infections
    CHARLES FULHORST; Fiscal Year: 2003
    ..g., Amapari, Flexal) that were not used to develop or test the first generation assay. ..
  26. ECOLOGY OF EMERGING ARENAVIRUSES IN SOUTHWESTERN U.S.
    CHARLES FULHORST; Fiscal Year: 2004
    ..S.; and, 5) investigate further the human health significance of North American rodent-borne arena viruses. ..
  27. Animal models of hantavirus cardiopulmonary disease
    CHARLES FULHORST; Fiscal Year: 2006
    ..A mouse model of severe or lethal HCPS could substantively augment studies on the pathogenesis of the capillary leak that results in the life-threatening pulmonary edema HCPS. ..
  28. Animal Models in Type 1 Diabetes and Multiple Sclerosis
    Matthias von Herrath; Fiscal Year: 2006
    ..Additionally, we expect that this symposium will be of interest to junior faculty working in the areas of autoimmune disease research, as well as patient advocacy groups. [unreadable] [unreadable] [unreadable]..
  29. CXCR3 Chemokines in Type I Diabetes
    Matthias von Herrath; Fiscal Year: 2009
    ..Aim 1: Importance of IP-10 in the pathogenesis of T1D - therapeutic blockade and mechanistic analyses. Aim 2: Importance of IP-10 during islet allograft rejection - therapeutic blockade and mechanistic analyses. ..
  30. MOLECULAR ANALYSIS OF A NEUROTROPIC AGENT--BORNA VIRUS
    WALTER LIPKIN; Fiscal Year: 2002
    ....
  31. Chimeric hepatitis C vaccine vector
    JACK NUNBERG; Fiscal Year: 2004
    ..Viable chimeric viruses will enable the study in cell culture of HCV binding and entry, as well as virion assembly and morphogenesis, and may provide a starting point towards the development of an attenuated HCV vaccine. ..
  32. Mass Tag PCR Detection of Respiratory Pathogens
    W Ian Lipkin; Fiscal Year: 2004
    ..abstract_text> ..
  33. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  34. ROLE OF ICOS IN T CELL RESPONSES AND ANTI-TUMOR IMMUNITY
    Gordon Freeman; Fiscal Year: 2004
    ..To examine the expression the expression of ICOS counter-receptor on APC and characterize its molecular structure. SPECIFIC AIM 3. To examine how blocking ICOS signals affect the immune response to murine tumors. ..
  35. How IL-10R blockade can resolve persistent viral infections
    Matthias G Von Herrath; Fiscal Year: 2010
    ..In order to assure that our findings reach those groups working on HIV and HCV, cooperations have been established with leading groups in the field. ..
  36. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  37. Genetic analysis of the HIV gp120-gp41 interface
    JACK NUNBERG; Fiscal Year: 2004
    ..This knowledge will guide efforts to design envelope glycoprotein immunogens and to develop antiviral inhibitors to prevent viral entry. ..
  38. FUSION COMPETENT HIV VACCINE IMMUNOGENS
    JACK NUNBERG; Fiscal Year: 2002
    ....
  39. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  40. Dynamics of arenavirus gene expression in vivo
    Jason Botten; Fiscal Year: 2004
    ..Our findings could be applicable to other RNA viruses that cause persistent infection. ..
  41. DNA Vaccination & Regulatory Cells in Type I Diabetes
    Matthias von Herrath; Fiscal Year: 2006
    ..abstract_text> ..
  42. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  43. A Staged Strategy for Virus Identification and Discovery
    W Ian Lipkin; Fiscal Year: 2005
    ..Our initial focus will be two chronic diseases where specific viral taxa are associated and potentially implicated in pathogenesis: bronchioalveolar cell carcinoma and amyotrophic lateral sclerosis. ..
  44. Novel Molecules that Define Viral Persistence
    David Brooks; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  45. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
    ..abstract_text> ..
  46. Structure-function of Junin virus envelope glycoproteins
    JACK NUNBERG; Fiscal Year: 2005
    ..This application is submitted in response to PA-03-080 for Biodefense and Emerging Infectious Disease Research. ..
  47. How Does blockade of CD40/CD40L Prevent Autoimmunity?
    Matthias von Herrath; Fiscal Year: 2005
    ..Therefore, the direct comparison of three autoimmune models will enable us to define, which in vivo consequences of costimulation blockade occur more commonly and which are restricted to a given experimental situation. ..
  48. Cellular receptors for pathogenic New World arenaviruses
    Stefan Kunz; Fiscal Year: 2007
    ..In a complementary approach, biochemical techniques, combined with mass spectrometry, will therefore be used for the identification of candidate receptors for this important human pathogen. [unreadable] [unreadable] [unreadable]..
  49. Role of a Non-Tolerant Autoantigen in Autoimmunity
    Matthias von Herrath; Fiscal Year: 2007
    ..abstract_text> ..
  50. IMMUNE TOLERANCE INDUCTION BY APOPTOTIC BODIES
    Matthias von Herrath; Fiscal Year: 2005
    ..abstract_text> ..
  51. Pathogen Discovery in Chronic Lung Disease by Mass Tag PCR and Microarray
    W Ian Lipkin; Fiscal Year: 2009
    ....
  52. A DEVELOPMENTAL MODEL FOR AUTISM BASED ON CNS INFECTION
    WALTER LIPKIN; Fiscal Year: 2004
    ..4) Determine how opoptosis contributes to the neuropathology observed after neonatal infection. (5) Analyze regional changes in neurotransmitter systems following neonatal infection. ..
  53. A Staged Strategy for Virus Identification and Discovery
    WALTER LIPKIN; Fiscal Year: 2004
    ..Consistent with aims proposed in AI51292, our initial clinical application will be to analyze enteroviral serotypes implicated in human disease in North America. ..
  54. BORNA DISEASE VIRUS AND NEUROPSYCHIATRIC DISEASE
    WALTER LIPKIN; Fiscal Year: 2002
    ..This study will be the first to collect and process human sera and PBMC samples in clinical laboratories with no history of BDV research and dispense aliquots to a central laboratory for randomized, blinded analysis. ..