arenaviridae infections

Summary

Summary: Virus diseases caused by the ARENAVIRIDAE.

Top Publications

  1. ncbi Genetic detection and characterization of Lujo virus, a new hemorrhagic fever-associated arenavirus from southern Africa
    Thomas Briese
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA
    PLoS Pathog 5:e1000455. 2009
  2. ncbi The role of the vascular endothelium in arenavirus haemorrhagic fevers
    Stefan Kunz
    Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland
    Thromb Haemost 102:1024-9. 2009
  3. ncbi Animal models of highly pathogenic RNA viral infections: hemorrhagic fever viruses
    Brian B Gowen
    Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 78:79-90. 2008
  4. ncbi A new arenavirus in a cluster of fatal transplant-associated diseases
    Gustavo Palacios
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    N Engl J Med 358:991-8. 2008
  5. ncbi In vitro and in vivo activities of T-705 against arenavirus and bunyavirus infections
    Brian B Gowen
    Institute for Antiviral Research, Utah State University, Logan, UT 84322, USA
    Antimicrob Agents Chemother 51:3168-76. 2007
  6. ncbi Junin virus vaccines
    D A Enria
    Instituto Nacional de Enfermedades Virales Humanas (INEVH, Dr. Julio I. Maiztegui, Monteagudo 2510, 2700 Pergamino, Argentina
    Curr Top Microbiol Immunol 263:239-61. 2002
  7. ncbi Regulation of homeostatic chemokine expression and cell trafficking during immune responses
    Scott N Mueller
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Science 317:670-4. 2007
  8. ncbi Arenaviruses other than Lassa virus
    Remi N Charrel
    Unite des Virus Emergents, EA 3292, IRD UR 034, IFR 48, Faculte de Medecine, 27 Boulevard Jean Moulin, Marseille 13005, France
    Antiviral Res 57:89-100. 2003
  9. ncbi Antigen-independent memory CD8 T cells do not develop during chronic viral infection
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Room G211, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 101:16004-9. 2004
  10. ncbi Mucosal arenavirus infection of primates can protect them from lethal hemorrhagic fever
    Juan D Rodas
    Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21201, USA
    J Med Virol 72:424-35. 2004

Research Grants

  1. MOLECULAR BIOLOGY OF BORNA DISEASE VIRUS (BDV)
    JUAN DE LA TORRE; Fiscal Year: 2004
  2. Neuroimmunologic Disorders Induced by Chronic Viral Infection
    JUAN DE LA TORRE; Fiscal Year: 2007
  3. Identification of Borna Disease Virus Receptor Proteins
    JUAN DE LA TORRE; Fiscal Year: 2006
  4. Novel Antiviral Strategy to Combat Arenaviruses
    JUAN DE LA TORRE; Fiscal Year: 2004
  5. Aminoglycoside Antivirals to Combat Arenaviruses
    JUAN DE LA TORRE; Fiscal Year: 2004
  6. REVERSE GENETICS OF ARENAVIRUSES
    JUAN DE LA TORRE; Fiscal Year: 2005
  7. REVERSE GENETICS OF ARENAVIRUSES
    JUAN DE LA TORRE; Fiscal Year: 2007
  8. Immune cell dynamics during central nervous system viral infection
    Juan C de la Torre; Fiscal Year: 2010
  9. Anti-interferon Activity of the Arenavirus Nucleoprotein
    Luis Martinez Sobrido; Fiscal Year: 2010
  10. Targeting the processing of the arenavirus glycoprotein for anti-viral therapy.
    Juan C de la Torre; Fiscal Year: 2010

Detail Information

Publications160 found, 100 shown here

  1. ncbi Genetic detection and characterization of Lujo virus, a new hemorrhagic fever-associated arenavirus from southern Africa
    Thomas Briese
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA
    PLoS Pathog 5:e1000455. 2009
    ..LUJV is a novel, genetically distinct, highly pathogenic arenavirus...
  2. ncbi The role of the vascular endothelium in arenavirus haemorrhagic fevers
    Stefan Kunz
    Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland
    Thromb Haemost 102:1024-9. 2009
    ..These studies provided first possible links to some of the vascular abnormalities observed in patients, however, their relevance in vivo remains to be investigated...
  3. ncbi Animal models of highly pathogenic RNA viral infections: hemorrhagic fever viruses
    Brian B Gowen
    Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 78:79-90. 2008
    ..Such models are sufficient for testing of drugs that directly block viral replication, but may be inadequate for evaluating therapies that depend for their success on the activation or inhibition of host responses...
  4. ncbi A new arenavirus in a cluster of fatal transplant-associated diseases
    Gustavo Palacios
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    N Engl J Med 358:991-8. 2008
    ..Culture, polymerase-chain-reaction (PCR) and serologic assays, and oligonucleotide microarray analysis for a wide range of infectious agents were not informative...
  5. ncbi In vitro and in vivo activities of T-705 against arenavirus and bunyavirus infections
    Brian B Gowen
    Institute for Antiviral Research, Utah State University, Logan, UT 84322, USA
    Antimicrob Agents Chemother 51:3168-76. 2007
    ..Our results suggest that T-705 may be a viable alternative for the treatment of life-threatening bunyaviral and arenaviral infections...
  6. ncbi Junin virus vaccines
    D A Enria
    Instituto Nacional de Enfermedades Virales Humanas (INEVH, Dr. Julio I. Maiztegui, Monteagudo 2510, 2700 Pergamino, Argentina
    Curr Top Microbiol Immunol 263:239-61. 2002
  7. ncbi Regulation of homeostatic chemokine expression and cell trafficking during immune responses
    Scott N Mueller
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Science 317:670-4. 2007
    ..We propose that this transient chemokine modulation may help orchestrate local cellularity, thus minimizing competition for space and resources in activated lymphoid tissues...
  8. ncbi Arenaviruses other than Lassa virus
    Remi N Charrel
    Unite des Virus Emergents, EA 3292, IRD UR 034, IFR 48, Faculte de Medecine, 27 Boulevard Jean Moulin, Marseille 13005, France
    Antiviral Res 57:89-100. 2003
    ....
  9. ncbi Antigen-independent memory CD8 T cells do not develop during chronic viral infection
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Room G211, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 101:16004-9. 2004
    ..These findings raise concerns about using vaccines that may persist and also suggest that there may be limitations and challenges in designing effective immunological interventions for the treatment of chronic infections and tumors...
  10. ncbi Mucosal arenavirus infection of primates can protect them from lethal hemorrhagic fever
    Juan D Rodas
    Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21201, USA
    J Med Virol 72:424-35. 2004
    ..Cross protection between the two strains was observed. The three out of seven monkeys that experienced protection were also the three with the strongest cell-mediated immunity...
  11. ncbi Identification of differentially activated cell-signaling networks associated with pichinde virus pathogenesis by using systems kinomics
    Gavin C Bowick
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Virol 81:1923-33. 2007
    ..We believe that these nodes provide potential targets for the development of antiviral therapies by acting at the level of the host response rather than by directly targeting viral proteins...
  12. ncbi The CD8+ T-cell response to lymphocytic choriomeningitis virus involves the L antigen: uncovering new tricks for an old virus
    Maya F Kotturi
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    J Virol 81:4928-40. 2007
    ..Taken together, these findings illustrate that the LCMV-specific CD8(+) T-cell response is more complex than previously appreciated...
  13. ncbi Genetic identification of Kodoko virus, a novel arenavirus of the African pigmy mouse (Mus Nannomys minutoides) in West Africa
    E Lecompte
    Institute of Virology, Philipps University, Hans Meerweinstrasse, 35 043 Marburg, Germany
    Virology 364:178-83. 2007
    ..The finding of an Old World arenavirus related to LCMV outside the known geographical range of LCMV in a novel rodent species reveals new insights about the evolutionary history of arenaviruses...
  14. ncbi Catarina virus, an arenaviral species principally associated with Neotoma micropus (southern plains woodrat) in Texas
    Maria N B Cajimat
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
    Am J Trop Med Hyg 77:732-6. 2007
    ....
  15. ncbi Is there an association of Pneumocystis infection with the presence of arena-, hanta-, and poxvirus antibodies in wild mice and shrews in Finland?
    J Laakkonen
    Department of Virology, Haartman Institute, P O Box 21, FIN 00014 University of Helsinki, Finland
    Parasitology 132:461-6. 2006
    ..Concurrent presence of virus antibodies (LCMV) and cyst forms of Pneumocystis were detected only in 1 M. minutus. In conclusion, we found no evidence of any association between Pneumocystis and antibodies to any of the viruses tested...
  16. ncbi LCMV-mediated hepatitis in rhesus macaques: WE but not ARM strain activates hepatocytes and induces liver regeneration
    I S Lukashevich
    Biotechnology Center, Institute of Human Virology, University of Maryland, Baltimore, Maryland 21201, USA
    Arch Virol 149:2319-36. 2004
    ..Previously we demonstrated that LCMV-ARM infection protected rhesus macaques challenged with LCMV-WE. Here we have shown that the protected animals have no signs of hepatitis and hepatocyte proliferation...
  17. ncbi Human infection with arenaviruses in the Americas
    C J Peters
    University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-0609, USA
    Curr Top Microbiol Immunol 262:65-74. 2002
  18. ncbi CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors
    Loui T Madakamutil
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Science 304:590-3. 2004
    ..Thus, memory precursors can be identified among primary effector cells and are selected for survival and differentiation by CD8alphaalpha...
  19. ncbi Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection
    Khuong B Nguyen
    Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    Science 297:2063-6. 2002
    ..Thus, type 1 IFNs, in addition to interleukin-12, provide pathways for innate regulation of adaptive immunity, and their immunoregulatory functions are controlled by modulating the activity of individual STATs...
  20. ncbi Targeting Schwann cells by nonlytic arenaviral infection selectively inhibits myelination
    Anura Rambukkana
    Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, NY10021, USA
    Proc Natl Acad Sci U S A 100:16071-6. 2003
    ....
  21. ncbi Endothelial cell function alteration after Junin virus infection
    Ricardo Martin Gomez
    Department of Microbiology, Faculty of Medicine, University of Buenos Aires, CONICET, Argentina
    Thromb Haemost 90:326-33. 2003
    ..These data demonstrate that endothelial cell responses are triggered subsequently by JV infection, suggesting that such alterations play a major role in the pathogenesis of AHF and perhaps in other viral-induced hemorrhagic diseases...
  22. ncbi Genomic features of attenuated Junín virus vaccine strain candidate
    Sandra Elizabeth Goñi
    LIGBCM, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Rogue Saenz Peña 180, B1876BXD, Bernal, Buenos Aires, Argentina
    Virus Genes 32:37-41. 2006
    ..These changes could be provisionally associated with the attenuated phenotype. In contrast, Z ORF was completely conserved among all strains...
  23. ncbi Evolution of the Old World Arenaviridae and their rodent hosts: generalized host-transfer or association by descent?
    J P Hugot
    Museum national d histoire naturelle, Institut de Systématique, FR 1541 du CNRS, Biosystématique et Coévolution chez les Nématodes Parasites, 75231 Cedex 05, Paris, France
    Infect Genet Evol 1:13-20. 2001
    ..This supposes that the origin of the arenaviruses has to be found out of Africa...
  24. ncbi Hypergammaglobulinemia and autoantibody induction mechanisms in viral infections
    Lukas Hunziker
    Institute for Experimental Immunology, University Hospital, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Nat Immunol 4:343-9. 2003
    ..This nonspecific B cell activation may contribute to antibody-mediated autoimmunity...
  25. ncbi Interferon-gamma acts directly on CD8+ T cells to increase their abundance during virus infection
    Jason K Whitmire
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 201:1053-9. 2005
    ..The stimulatory effect is abrogated in T cells lacking the IFNgamma receptor, indicating that the cytokine acts directly upon CD8(+) T cells to increase their abundance during acute viral infection...
  26. ncbi Transmission of lymphocytic choriomeningitis virus by organ transplantation
    Staci A Fischer
    Rhode Island Hospital and Brown Medical School, Providence, USA
    N Engl J Med 354:2235-49. 2006
    ..One recipient, who received ribavirin and reduced levels of immunosuppressive therapy, survived. CONCLUSIONS: We document two clusters of LCMV infection transmitted through organ transplantation...
  27. ncbi Arenavirus-mediated liver pathology: acute lymphocytic choriomeningitis virus infection of rhesus macaques is characterized by high-level interleukin-6 expression and hepatocyte proliferation
    Igor S Lukashevich
    Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21201, USA
    J Virol 77:1727-37. 2003
    ..Our data confirm that acute infection is associated with weak inflammatory responses in tissues and initiates a program of liver regeneration in primates...
  28. ncbi Arenavirus extinction through lethal mutagenesis
    Juan Carlos de la Torre
    Department of Neuropharmacology IMM 6, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Virus Res 107:207-14. 2005
    ..These findings indicate that, as with other riboviruses, lethal mutagenesis is effective also against LCMV raising the possibility of using this novel antiviral strategy to combat pathogenic arenaviruses...
  29. ncbi Arenaviruses
    J P Gonzalez
    IRD U178, Conditions et Territoires d Emergence des Maladies, Thaïlande, France
    Curr Top Microbiol Immunol 315:253-88. 2007
    ..The diversity among rodent host reservoir and virus species and the potential to exchange genomic material provide a basis for the emergence of new viruses and the risk of these becoming pathogenic for humans...
  30. ncbi Lassa and Mopeia virus replication in human monocytes/macrophages and in endothelial cells: different effects on IL-8 and TNF-alpha gene expression
    I S Lukashevich
    Department of Pathology, University of Wisconsin, Madison, Wisconsin, USA
    J Med Virol 59:552-60. 1999
    ..The cumulative down-regulation of TNF-alpha and IL-8 expression could explain the absence of inflammatory and effective immune responses in severe cases of Lassa HF...
  31. ncbi Diversity among Tacaribe serocomplex viruses (family Arenaviridae) naturally associated with the Mexican woodrat (Neotoma mexicana)
    Maria N B Cajimat
    Microbiology and Immunology Graduate Program, Graduate School of Biomedical Sciences, University of Texas Medical Branch, Galveston, TX 77555 1019, USA
    Virus Res 133:211-7. 2008
    ..Conceptually, the viruses from Colorado, New Mexico, and Utah and strain AV 9310135 could be grouped together in a species complex in the family Arenaviridae, genus Arenavirus...
  32. ncbi IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection
    David G Brooks
    Viral Immunobiology Laboratory, Department of Molecular and Integrative Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 205:533-41. 2008
    ..Consequently, blocking key suppressive factors could render ineffective vaccines more efficient at improving T cell immunity, and thereby allow immune-mediated control of persistent viral infection...
  33. ncbi Arenavirus antibody in rodents indigenous to coastal southern California
    S G Bennett
    Orange County Vector Control District, Garden Grove, California 92843, USA
    Am J Trop Med Hyg 62:626-30. 2000
    ....
  34. ncbi Clinical case definitions for Argentine hemorrhagic fever
    L H Harrison
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pennsylvania 15261, USA
    Clin Infect Dis 28:1091-4. 1999
    ....
  35. ncbi Experimental infection of Neotoma albigula (Muridae) with Whitewater Arroyo virus (Arenaviridae)
    C F Fulhorst
    Department of Pathology and World Health Organization Collaborating Center for Tropical Diseases, University of Texas Medical Branch, Galveston 77555 0609, USA
    Am J Trop Med Hyg 65:147-51. 2001
    ..These results indicate that the duration of WWA virus infection in N. albigula is dependent upon the animal's age at the onset of infection and that neonatal infection can result in chronic (perhaps lifelong) virus shedding...
  36. ncbi Lymphocytic choriomeningitis virus: emerging fetal teratogen
    Leslie L Barton
    Department of Pediatrics and Steele Memorial Children s Research Center, University of Arizona, Tucson 85724, USA
    Am J Obstet Gynecol 187:1715-6. 2002
    ..We strongly suggest that obstetricians counsel their pregnant patients regarding the potential hazard that contact with infected pet, laboratory, and household mice and hamsters poses to pregnant women and their unborn children...
  37. ncbi Current progress towards vaccines for arenavirus-caused diseases
    J C Clegg
    Division of Pathology, Centre for Applied Microbiology and Research, Salisbury, Wilts, UK
    Vaccine 10:89-95. 1992
    ....
  38. ncbi The RING domain and the L79 residue of Z protein are involved in both the rescue of nucleocapsids and the incorporation of glycoproteins into infectious chimeric arenavirus-like particles
    Juan Cruz Casabona
    Centro de Virologia Animal CEVAN, Instituto de Ciencia y Tecnología Dr Cesar Milstein, Consejo Nacional de Ciencia y Tecnología CONICET, Saladillo 2468, C1440FFX Ciudad Autónoma de Buenos Aires, Argentina
    J Virol 83:7029-39. 2009
    ..Our results support the conclusion that the interaction between Z and N is required for assembly of both the nucleocapsids and the glycoproteins into infectious arenavirus budding particles...
  39. ncbi Molecular phylogeny of Guanarito virus, an emerging arenavirus affecting humans
    J P Gonzalez
    Institut Francais de Recherche Scientifique pour le Developpement en Cooperation ORSTOM, Paris, France
    Am J Trop Med Hyg 53:1-6. 1995
    ..Along with its host restriction and focal distribution, our data support the hypothesis that this virus has been evolving independently in its endemic focus, for some time...
  40. ncbi Interferon alfacon-1 protects hamsters from lethal pichinde virus infection
    Brian B Gowen
    Institute for Antiviral Research, 5600 Old Main Hill, Utah State University, Logan, UT 84322, USA
    Antimicrob Agents Chemother 49:2378-86. 2005
    ..These data are the first report demonstrating efficacious treatment of acute arenaviral disease with alpha interferon therapy, and further study is warranted...
  41. ncbi Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection
    Sang Jun Ha
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 205:543-55. 2008
    ..Such an approach may have broad applications in developing treatment strategies for chronic infections in general, and perhaps also for tumors...
  42. ncbi Combinatorial ribavirin and interferon alfacon-1 therapy of acute arenaviral disease in hamsters
    Brian B Gowen
    Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 17:175-83. 2006
    ..Further, combination therapy reduces the effective dosage of ribavirin, which would serve to limit its toxicity...
  43. ncbi Hemorrhagic fever viruses as biological weapons: medical and public health management
    Luciana Borio
    Johns Hopkins Center for Civilian Biodefense Strategies, Johns Hopkins Schools of Medicine and Public Health, 111 Market Pl, Suite 830, Baltimore, MD 21202, USA
    JAMA 287:2391-405. 2002
    ..To develop consensus-based recommendations for measures to be taken by medical and public health professionals if hemorrhagic fever viruses (HFVs) are used as biological weapons against a civilian population...
  44. ncbi Cytokine patterns in a comparative model of arenavirus haemorrhagic fever in guinea pigs
    Erin P Scott
    Department of Pathology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0747, USA
    J Gen Virol 89:2569-79. 2008
    ..Suppression rather than overexpression of pro-inflammatory cytokines accompanied the terminal shock in this model of arenavirus haemorrhagic fever...
  45. ncbi Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection
    Ganesh A Kolumam
    Department of Immunology, University of Washington, Seattle, 98195, USA
    J Exp Med 202:637-50. 2005
    ..Thus, IFN-IR signaling in CD8 T cells is critical for the generation of effector and memory cells in response to viral infection...
  46. ncbi Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin
    Andrew M Intlekofer
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 321:408-11. 2008
    ..T-bet and Eomes, thus, ensure that CD8+ T cells adopt an appropriate course of intracellular rather than extracellular destruction...
  47. ncbi Interleukin-21 mRNA expression during virus infections
    Christian Holm
    Institute of Medical Microbiology and Immunology, Bartholin Building, University of Aarhus, 8000 Aarhus C, Denmark
    Cytokine 33:41-5. 2006
    ..Thus, our data suggest a role for IL-21 in the early stages of adaptive immune response against virus infections...
  48. ncbi Evaluating the immunogenicity and protective efficacy of a DNA vaccine encoding Lassa virus nucleoprotein
    Maria P Rodriguez-Carreno
    Department of Neuropharmacology, CVN 9, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Virology 335:87-98. 2005
    ..A DNA minigene vaccine encoding a 9 amino acid sequence from LNP also induces CD8(+) T cells and protects against arenavirus challenge, thus confirming prior speculation that protective cellular immunity is induced by LV proteins...
  49. ncbi Protein kinase C-theta critically regulates the proliferation and survival of pathogen-specific T cells in murine listeriosis
    Monika Sakowicz-Burkiewicz
    Institut fur Medizinische Mikrobiologie, Otto von Guericke Universitat Magdeburg, Magdeburg, Germany
    J Immunol 180:5601-12. 2008
    ....
  50. ncbi Precursor frequency, nonlinear proliferation, and functional maturation of virus-specific CD4+ T cells
    Jason K Whitmire
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 176:3028-36. 2006
    ....
  51. ncbi Persistent virus infection inhibits type I interferon production by plasmacytoid dendritic cells to facilitate opportunistic infections
    Elina I Zuniga
    Department of Immunology and Microbial Sciences, Scripps Research Institute, La Jolla, CA 92037, USA
    Cell Host Microbe 4:374-86. 2008
    ..These findings provide a mechanistic explanation for the occurrence of opportunistic infections following viral insults and have important implications for treating such medical complications...
  52. ncbi Diminished primary CD8 T cell response to viral infection during protein energy malnutrition in mice is due to changes in microenvironment and low numbers of viral-specific CD8 T cell precursors
    Janel Hart Chatraw
    Department of Rehabilitation Medicine, Division of Physical Therapy, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Nutr 138:806-12. 2008
    ..Furthermore, the diminished primary CD8 T cell response during PEM may in part have been due to low numbers of viral-specific CD8 T cells and an altered microenvironment...
  53. ncbi Abrogation of CCL21 chemokine function by transgenic over-expression impairs T cell immunity to local infections
    Heike Unsoeld
    Department of Immunology, Institute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    Int Immunol 19:1281-9. 2007
    ..Taken together, these data demonstrate the importance of CCR7 in mediating T cell immunity to viral and parasitic pathogens after local infection...
  54. ncbi CCR5 and CXCR3 are dispensable for liver infiltration, but CCR5 protects against virus-induced T-cell-mediated hepatic steatosis
    P J Holst
    Institute of Medical Microbiology and Immunology, University of Copenhagen, The Panum Institute, 3C Blegdamsvej, DK 2200 Copenhagen N, Denmark
    J Virol 81:10101-12. 2007
    ....
  55. ncbi Generation and maintenance of Listeria-specific CD8+ T cell responses in perforin-deficient mice chronically infected with LCMV
    Troy D Humphreys
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    Virology 370:310-22. 2008
    ....
  56. ncbi Differential microenvironment localization of effector and memory CD8 T cells
    Joseph G Dauner
    Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Center, Emory University School of Medicine, Atlanta, GA 30329, USA
    J Immunol 180:291-9. 2008
    ..Upon rechallenge, memory CD8 T cells rapidly proliferate and the secondary effector CD8 T cells are found in the red pulp...
  57. ncbi Phenotypic and functional analysis of LCMV gp33-41-specific CD8 T cells elicited by multiple peptide immunization in mice revealed the up-regulation of PD-1 expression on antigen-specific CD8 T cells
    Yi Liu
    Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
    Cell Mol Immunol 4:431-7. 2007
    ....
  58. ncbi The role of endoplasmic reticulum-associated aminopeptidase 1 in immunity to infection and in cross-presentation
    Elke Firat
    Clinic for Radiotherapy, University Hospital of Freiburg, Freiburg, Germany
    J Immunol 178:2241-8. 2007
    ..Surprisingly, however, ERAP1 deficiency has no effect on cross-presentation of soluble OVA, suggesting that for soluble exogenous proteins, final processing may not take place in an environment containing active ERAP1...
  59. ncbi Control of virus-specific CD8+ T-cell exhaustion and immune-mediated pathology by E3 ubiquitin ligase Cbl-b during chronic viral infection
    Rong Ou
    Center for Molecular Chaperones Radiobiology and Cancer Virology, Medical College of Georgia, 1410 Laney Walker Blvd, Augusta, GA 30912, USA
    J Virol 82:3353-68. 2008
    ..In conclusion, our results suggest that Cbl-b is critically involved in T-cell exhaustion and prevention of lethal disease...
  60. ncbi Augmented IL-7 signaling during viral infection drives greater expansion of effector T cells but does not enhance memory
    Joseph C Sun
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    J Immunol 177:4458-63. 2006
    ..The extent of contraction may be dictated by intrinsic factors related to the number of prior cell divisions...
  61. ncbi CD4+ T cell help improves CD8+ T cell memory by retained CD27 expression
    Matthias S Matter
    Tumor Immunology, Department of Clinical Research, University of Berne, Bern, Switzerland
    Eur J Immunol 38:1847-56. 2008
    ..Therefore, regulating CD27 expression on memory CTL is a novel mechanism how CD4+ T cells control CTL memory...
  62. ncbi An altered T cell repertoire in MECL-1-deficient mice
    Michael Basler
    Division of Immunology, Department of Biology, University of Constance, Konstanz, Germany
    J Immunol 176:6665-72. 2006
    ..Taken together, our data reveal an in vivo function of MECL-1 in codetermining the T cell repertoire for an antiviral CTL response...
  63. ncbi Lambda interferon (IFN-lambda), a type III IFN, is induced by viruses and IFNs and displays potent antiviral activity against select virus infections in vivo
    Nina Ank
    Institute of Medical Microbiology and Immunology, The Bartholin Building, University of Aarhus, DK-8000 Aarhus C, Denmark
    J Virol 80:4501-9. 2006
    ....
  64. ncbi Clearance of an immunosuppressive virus from the CNS coincides with immune reanimation and diversification
    Henning Lauterbach
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Virol J 4:53. 2007
    ....
  65. ncbi Impaired virus control and severe CD8+ T-cell-mediated immunopathology in chimeric mice deficient in gamma interferon receptor expression on both parenchymal and hematopoietic cells
    Pernille Henrichsen
    Institute of Medical Microbiology and Immunology, University of Copenhagen, Denmark
    J Virol 79:10073-6. 2005
    ..Further, the study shows that IFN-gamma receptor expression on parenchymal cells in the viscera is more important for virus control than IFN-gamma receptor expression on bone marrow-derived cells...
  66. ncbi Inverse correlation between IL-7 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation
    Karl S Lang
    Institute of Experimental Immunology, Zurich, Switzerland
    Eur J Immunol 35:738-45. 2005
    ..Persistent antigen also suppressed IL-7Ralpha expression on primed T cells and this correlated with exhaustion of a previously stable primed T cell population. These findings suggest that antigen longevity regulates T cell fate...
  67. ncbi Primary and secondary immunocompetence in mixed allogeneic chimeras
    Matthew A Williams
    Emory Transplant Center and Department of Surgery, Emory University School of Medicine, Atlanta, GA, 30322, USA
    J Immunol 170:2382-9. 2003
    ....
  68. ncbi Requirement for CD4 T cell help in generating functional CD8 T cell memory
    Devon J Shedlock
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 300:337-9. 2003
    ..These results demonstrate a previously undescribed role for CD4 help in the development of functional CD8 memory...
  69. ncbi Virus-specific CD8 T cells in peripheral tissues are more resistant to apoptosis than those in lymphoid organs
    Xiaoting Z Wang
    Department of Pathology, University of Massachusetts Medical School, Worcester 01655, USA
    Immunity 18:631-42. 2003
    ..This may contribute to the survival of nondividing peripheral memory T cells, enabling them to efficiently function without being driven into apoptosis...
  70. ncbi Attrition of virus-specific memory CD8+ T cells during reconstitution of lymphopenic environments
    Craig D Peacock
    Department of Pathology, University of Massachusetts Medical Center, Worcester, MA 01655, USA
    J Immunol 171:655-63. 2003
    ....
  71. ncbi Control of effector CD8+ T cell function by the transcription factor Eomesodermin
    Erika L Pearce
    Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 302:1041-3. 2003
    ..We suggest that Eomesodermin is likely to complement the actions of T-bet and act as a key regulatory gene in the development of cell-mediated immunity...
  72. ncbi Role of CD28 co-stimulation in generation and maintenance of virus-specific T cells
    Jeanette E Christensen
    Institute of Medical Microbiology and Immunology, Panum Institute, 3C Blegdamsvej, 2200 Copenhagen, Denmark
    Int Immunol 14:701-11. 2002
    ....
  73. ncbi Dynamics of memory T cell proliferation under conditions of heterologous immunity and bystander stimulation
    Sung Kwon Kim
    Department of Pathology, University of Massachusetts, Worcester, MA 01655, USA
    J Immunol 169:90-8. 2002
    ..Thus, depending on the pathogen and the sequence of infection, a heterologous agent may selectively stimulate the memory pool in patterns consistent with heterologous immunity...
  74. ncbi Modelling the dynamics of LCMV infection in mice: II. Compartmental structure and immunopathology
    Gennady Bocharov
    Institute of Numerical Mathematics, Russian Academy of Sciences, Moscow, Russia
    J Theor Biol 221:349-78. 2003
    ..It specifies objectives for CTL vaccination to ensure virus elimination with minimal immunopathology vs. vaccination for disease...
  75. ncbi Functional characterization of MHC class II-restricted CD8+CD4- and CD8-CD4- T cell responses to infection in CD4-/- mice
    Erika L Pearce
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 173:2494-9. 2004
    ..These results have implications for understanding thymic T cell selection and for elucidating the mechanisms regulating the peripheral immune response and memory differentiation...
  76. ncbi Role of CD28-B7 interactions in generation and maintenance of CD8 T cell memory
    M Suresh
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 167:5565-73. 2001
    ..Therefore, CD28 signaling is not necessary for the proliferative renewal and maintenance of memory CD8 T cells...
  77. ncbi Immunology. CD8alphaalpha and T cell memory
    Sangwon V Kim
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 304:529-30. 2004
  78. ncbi Molecular analysis of the interaction of LCMV with its cellular receptor [alpha]-dystroglycan
    S Kunz
    The Scripps Research Institute, Division of Virology, Department of Neuropharmacology, La Jolla, CA 92037, USA
    J Cell Biol 155:301-10. 2001
    ..Infection followed by dysfunction of these antigen-presenting cells contributes to immunosuppression and persistent viral infection in vivo...
  79. ncbi Differential tissue-specific regulation of antiviral CD8+ T-cell immune responses during chronic viral infection
    Shenghua Zhou
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Virol 78:3578-600. 2004
    ....
  80. ncbi A structural basis for LCMV immune evasion: subversion of H-2D(b) and H-2K(b) presentation of gp33 revealed by comparative crystal structure.Analyses
    Adnane Achour
    Microbiology and Tumor Biology Center, Karolinska Institutet, Royal School of Technology, S 106 91 Stockholm, Sweden
    Immunity 17:757-68. 2002
    ..Importantly, the peptide's N-terminal residue p1K protrudes from the binding cleft in H-2K(b). We present structural evidence that explains the functional consequences of single mutations found in escape variants...
  81. ncbi [Neutralization test for lymphocytic choriomeningitis virus for distinguishing between two arenavirus infections in Argentina]
    A M Ambrosio
    Instituto Nacional de Enfermedades Virales Humanas Dr Julio I Maiztegui INEVH, Monteagudo 2510, 2700 Pergamino, Pcia de Buenos Aires, Argentina
    Rev Argent Microbiol 33:235-40. 2001
    ....
  82. ncbi HLA-A2-restricted protection against lethal lymphocytic choriomeningitis
    Jason Botten
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, SP30 2020, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Virol 81:2307-17. 2007
    ....
  83. ncbi Contributions of the lymphocytic choriomeningitis virus glycoprotein and polymerase to strain-specific differences in murine liver pathogenicity
    Andreas Bergthaler
    Institute of Experimental Immunology, Department of Pathology, University Hospital of Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland
    J Gen Virol 88:592-603. 2007
    ..This reverse-genetic approach to an animal model of arenaviral hepatitis reveals a previously underestimated contributory role of the GP that alone is, however, insufficient to cause disease...
  84. ncbi The nucleoprotein of Pichinde virus expressed by a vaccinia-Pichinde virus recombinant partially protects hamsters from lethal virus challenge
    D Y Ozols
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Arch Virol 139:23-36. 1994
    ..This finding appears to support the hypothesis that in many arenavirus infections cellular immunity is central to viral clearance and protection from reinfection...
  85. ncbi Targeting the proteolytic processing of the viral glycoprotein precursor is a promising novel antiviral strategy against arenaviruses
    Jillian M Rojek
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 920371, USA
    J Virol 84:573-84. 2010
    ....
  86. ncbi Dehydroepiandrosterone, epiandrosterone and synthetic derivatives inhibit Junin virus replication in vitro
    Eliana G Acosta
    Laboratorio de Virologia, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon 2, Piso 4, C1428EGA Buenos Aires, Argentina
    Virus Res 135:203-12. 2008
    ..Like DHEA and EA, three compounds obtained from EA by chemical synthesis showed selectivity indexes higher than ribavirin, the only antiviral compound that has shown partial efficacy against arenavirus infections...
  87. ncbi Lymphocytic choriomeningitis virus--an old enemy up to new tricks
    C J Peters
    Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, USA
    N Engl J Med 354:2208-11. 2006
  88. ncbi Models for an arenavirus infection in a rodent population: consequences of horizontal, vertical and sexual transmission
    Chandrani Banerjee
    Department of Mathematics and Statistics, Texas Tech University, Lubbock, TX 79409 1042, USA
    Math Biosci Eng 5:617-45. 2008
    ..Numerical examples illustrate the dynamics of the models. The biological implications of the results and future research goals are discussed in the conclusion...
  89. ncbi Treatment of late stage disease in a model of arenaviral hemorrhagic fever: T-705 efficacy and reduced toxicity suggests an alternative to ribavirin
    Brian B Gowen
    Institute for Antiviral Research, Logan, UT, USA
    PLoS ONE 3:e3725. 2008
    ..Our findings support further pre-clinical development of T-705 for the treatment of severe arenaviral infections...
  90. ncbi Design, synthesis, and biological evaluation of a biyouyanagin compound library
    K C Nicolaou
    Department of Chemistry, Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 108:6715-20. 2011
    ....
  91. ncbi Reverse genetics approaches to combat pathogenic arenaviruses
    Juan C de la Torre
    Immunology and Microbial Science, IMM 6, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Antiviral Res 80:239-50. 2008
    ..This, in turn, could lead to the development of novel, potent and safe arenavirus vaccines...
  92. ncbi Treatment of lethal Pichinde virus infections in weanling LVG/Lak hamsters with ribavirin, ribamidine, selenazofurin, and ampligen
    D F Smee
    Antiviral Program, Utah State University, Logan 84322
    Antiviral Res 20:57-70. 1993
    ..In fact, selenazofurin was overtly toxic, causing death of uninfected hamsters at 32 and 100 mg/kg. The random-bred LVG/Lak hamster appears to be a viable and cost-effective model for evaluating new therapies for arenavirus infections...
  93. ncbi Effects of promyelocytic leukemia protein on virus-host balance
    Weldy V Bonilla
    Institute of Experimental Immunology, University Hospital, CH 8091 Zurich, Switzerland
    J Virol 76:3810-8. 2002
    ..These in vivo observations corroborated our results showing more virus production in PML(-/-) fibroblasts. Thus, PML is a contributor to innate immunity, defining host susceptibility to viral infections and to immunopathology...
  94. ncbi The outcome of cross-priming during virus infection is not directly linked to the ability of the antigen to be cross-presented
    Attiya Alatery
    Department of Microbiology and Immunology, Queen s University, Kingston, ON, Canada
    Eur J Immunol 40:2190-9. 2010
    ..Thus, weak cross-presenting antigens may still cross-prime an efficient CTL response depending on other in vivo elements such as the naïve T-cell precursor frequencies...
  95. ncbi Systemic and mucosal infection program protective memory CD8 T cells in the vaginal mucosa
    Pratima Krishna Suvas
    Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
    J Immunol 179:8122-7. 2007
    ....
  96. ncbi Preliminary study on potential circulation of arenaviruses in the rodent population of Nakhon Pathom Province, Thailand and their medical importance in an evoluting environment
    N Nitatpattana
    Center for Vaccine Development, Institute of Science and Technology for Research and Development, Mahidol University, Nakhon Pathom, Thailand
    Southeast Asian J Trop Med Public Health 31:62-5. 2000
    ..05), however the seroprevalence found among different geographical areas of Nakhon Pathom Province were significantly different (p<0.0001)...
  97. ncbi Postinfectious encephalitis: a coregistered SPECT and magnetic resonance imaging study
    Emmanuel Itti
    Department of Radiology, Harbor-UCLA Medical Center, Torrance, 90509, USA
    Clin Nucl Med 27:129-30. 2002
  98. ncbi Pirital virus (Arenaviridae) infection in the syrian golden hamster, Mesocricetus auratus: a new animal model for arenaviral hemorrhagic fever
    S Y Xiao
    Department of Pathology, and the Center for Tropical Diseases, University of Texas Medical Branch, Galveston 77555 0588, USA
    Am J Trop Med Hyg 64:111-8. 2001
    ..It may also be useful for testingantiviral agents for treatment of arenaviral hemorrhagic fevers...
  99. ncbi Role of cell cycle regulator E2F1 in regulating CD8 T cell responses during acute and chronic viral infection
    Xiaoyan Gao
    Department of Pathobiological Sciences, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53706 1102, USA
    Virology 324:567-76. 2004
    ..Taken together, our studies show that E2F1, an important tumor suppressor and cell cycle regulator, may not have a non-redundant role in regulating CD8 T cell responses in acute and chronic LCMV infections...
  100. ncbi Junín virus infection of human hematopoietic progenitors impairs in vitro proplatelet formation and platelet release via a bystander effect involving type I IFN signaling
    Roberto G Pozner
    Department of Thrombosis and Hemostasis, Hematological Research Institute Mariano R Castex, National Academy of Medicine, CONICET, Buenos Aires, Argentina
    PLoS Pathog 6:e1000847. 2010
    ..Our study introduces a potential mechanism for thrombocytopenia in VHF and other diseases associated with increased bone marrow type I IFN levels...
  101. ncbi Signal 3 requirement for memory CD8+ T-cell activation is determined by the infectious pathogen
    Selina J Keppler
    Institute for Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Freiburg, Germany
    Eur J Immunol 41:3176-86. 2011
    ..In summary, our results reveal an essential role for direct inflammatory cytokine signaling in secondary T-cell responses...

Research Grants85

  1. MOLECULAR BIOLOGY OF BORNA DISEASE VIRUS (BDV)
    JUAN DE LA TORRE; Fiscal Year: 2004
    ..Conditions required for reconstitution of BDV transcription and RNA replication by intracellular coexpression of BDV minigenome and BDV proteins from separated plasmids will be determined. ..
  2. Neuroimmunologic Disorders Induced by Chronic Viral Infection
    JUAN DE LA TORRE; Fiscal Year: 2007
    ..Synaptic and dendritic structures will be quantitatively evaluated using antibodies to synaptophysine and MAP2, and confocal laser scanning microscopy to assess abnormalities associated with LCMV-cgPi. ..
  3. Identification of Borna Disease Virus Receptor Proteins
    JUAN DE LA TORRE; Fiscal Year: 2006
    ..G*/p56; 3) Determination of expression pattern of BDV candidate receptors in vivo. ..
  4. Novel Antiviral Strategy to Combat Arenaviruses
    JUAN DE LA TORRE; Fiscal Year: 2004
    ..abstract_text> ..
  5. Aminoglycoside Antivirals to Combat Arenaviruses
    JUAN DE LA TORRE; Fiscal Year: 2004
    ..Emergence of resistant variants will be assessed based on production of infectious virus and intracellular levels of virus RNA synthesis during serial passages in the presence of aminoglycosides with anti-LCMV activity. ..
  6. REVERSE GENETICS OF ARENAVIRUSES
    JUAN DE LA TORRE; Fiscal Year: 2005
    ..This will provide a new and powerful approach to the study of the arenavirus molecular biology and pathogenesis. ..
  7. REVERSE GENETICS OF ARENAVIRUSES
    JUAN DE LA TORRE; Fiscal Year: 2007
    ..We will use biochemical, genetics and functional assays to assess the relevance in Arenavirus biology of candidates initially identified by TAP/MS. ..
  8. Immune cell dynamics during central nervous system viral infection
    Juan C de la Torre; Fiscal Year: 2010
    ..abstract_text> ..
  9. Anti-interferon Activity of the Arenavirus Nucleoprotein
    Luis Martinez Sobrido; Fiscal Year: 2010
    ..This knowledge should fuel the development of better antiviral strategies to combat human pathogenic arenaviruses. ..
  10. Targeting the processing of the arenavirus glycoprotein for anti-viral therapy.
    Juan C de la Torre; Fiscal Year: 2010
    ....
  11. Reverse Genetics of Arenaviruses.
    Juan C de la Torre; Fiscal Year: 2010
    ..A detailed understanding of the arenavirus molecular will facilitate this task and cell biology, which is the long-term goal of the studies proposed in this application. ..
  12. MOLECULAR BIOLOGY OF BORNA DISEASE VIRUS (BDV)
    JUAN DE LA TORRE; Fiscal Year: 2000
    ....
  13. Animal models of hantavirus cardiopulmonary disease
    CHARLES FULHORST; Fiscal Year: 2006
    ..A mouse model of severe or lethal HCPS could substantively augment studies on the pathogenesis of the capillary leak that results in the life-threatening pulmonary edema HCPS. ..
  14. ECOLOGY OF EMERGING ARENAVIRUSES IN SOUTHWESTERN U S
    CHARLES FULHORST; Fiscal Year: 1999
    ..The project is of 3 years duration, consists of both field and laboratory studies, and involves the disciplines of virology, pathology, molecular biology, genetics, mammalogy, ecology and epidemiology. ..
  15. Recombinant Yellow Fever 17D-Lassa Vaccine
    Igor Lukashevich; Fiscal Year: 2007
    ..3. Efficacy, determine whether YF17D/LAS recombinants will effectively protect strain 13 guinea pigs against LAS virus challenge. Our long-term goal is to develop a live YF17D/LAS bivalent vaccine to control YF and LF in Africa. ..
  16. Viral determinants of hantavirus pulmonary disease in the hamster
    CHARLES FULHORST; Fiscal Year: 2007
    ..The plasmid-based genetic system could be used in future studies to develop vaccines to prevent infection or disease and to (in the face of clinical disease) mitigate the severity of HPS. ..
  17. Rapid, accurate diagnostics for arenaviral infections
    CHARLES FULHORST; Fiscal Year: 2003
    ..g., Amapari, Flexal) that were not used to develop or test the first generation assay. ..
  18. Viral determinants of hantavirus pulmonary disease in the hamster
    Charles F Fulhorst; Fiscal Year: 2010
    ..The plasmid-based genetic system could be used in future studies to develop vaccines to prevent infection or disease and to (in the face of clinical disease) mitigate the severity of HPS. ..
  19. ECOLOGY OF EMERGING ARENAVIRUSES IN SOUTHWESTERN U.S.
    CHARLES FULHORST; Fiscal Year: 2004
    ..S.; and, 5) investigate further the human health significance of North American rodent-borne arena viruses. ..
  20. Viral Arrays for Biodefense
    W Ian Lipkin; Fiscal Year: 2007
    ....
  21. IMMUNE TOLERANCE INDUCTION BY APOPTOTIC BODIES
    Matthias von Herrath; Fiscal Year: 2005
    ..abstract_text> ..
  22. Pathogenesis Studies in Scrapie (TSE Diseases)
    Michael Oldstone; Fiscal Year: 2003
    ..This model should be useful to study pathophysiology of CWD as well as probing CWD strain differences. ..
  23. BORNA DISEASE VIRUS AND NEUROPSYCHIATRIC DISEASE
    WALTER LIPKIN; Fiscal Year: 2002
    ..This study will be the first to collect and process human sera and PBMC samples in clinical laboratories with no history of BDV research and dispense aliquots to a central laboratory for randomized, blinded analysis. ..
  24. A Staged Strategy for Virus Identification and Discovery
    WALTER LIPKIN; Fiscal Year: 2004
    ..Consistent with aims proposed in AI51292, our initial clinical application will be to analyze enteroviral serotypes implicated in human disease in North America. ..
  25. A DEVELOPMENTAL MODEL FOR AUTISM BASED ON CNS INFECTION
    WALTER LIPKIN; Fiscal Year: 2004
    ..4) Determine how opoptosis contributes to the neuropathology observed after neonatal infection. (5) Analyze regional changes in neurotransmitter systems following neonatal infection. ..
  26. PATHOGENESIS OF PERSISTENT VIRAL INFECTION
    Michael Oldstone; Fiscal Year: 2006
    ..Lessons learned from this aspect of the LCMV model should provide insights for several persistent human viral infections that cause immunosuppression. ..
  27. Role of a Non-Tolerant Autoantigen in Autoimmunity
    Matthias von Herrath; Fiscal Year: 2007
    ..abstract_text> ..
  28. ARENAVIRUS RECEPTOR--STRUCTURE/FUNCTION STUDIES
    Michael Oldstone; Fiscal Year: 2007
    ..These findings have relevance for biodefense of several viruses including LFV. ..
  29. Pathogen Discovery in Chronic Lung Disease by Mass Tag PCR and Microarray
    W Ian Lipkin; Fiscal Year: 2009
    ....
  30. Pathogen Discovery in Chronic Lung Disease by Mass Tag PCR and Microarray
    W Ian Lipkin; Fiscal Year: 2007
    ....