herpes zoster

Summary

Summary: An acute infectious, usually self-limited, disease believed to represent activation of latent varicella-zoster virus (HERPESVIRUS 3, HUMAN) in those who have been rendered partially immune after a previous attack of CHICKENPOX. It involves the SENSORY GANGLIA and their areas of innervation and is characterized by severe neuralgic pain along the distribution of the affected nerve and crops of clustered vesicles over the area. (From Dorland, 27th ed)

Top Publications

  1. ncbi A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults
    M N Oxman
    Shingles Prevention Study Mail code 111F 1, VA San Diego Healthcare System, 3350 La Jolla Village Dr, San Diego, CA 92161, USA
    N Engl J Med 352:2271-84. 2005
  2. ncbi Herpes zoster incidence among insured persons in the United States, 1993-2006: evaluation of impact of varicella vaccination
    Jessica Leung
    National Center for Immunization and Respiratory Diseases NCIRD, Centers for Disease Control and Prevention CDC, Atlanta, Georgia 30333, USA
    Clin Infect Dis 52:332-40. 2011
  3. ncbi A population-based study of the incidence and complication rates of herpes zoster before zoster vaccine introduction
    Barbara P Yawn
    Department of Research, Olmsted Medical Center, 210 Ninth St SE, Rochester, MN, USA
    Mayo Clin Proc 82:1341-9. 2007
  4. ncbi Epidemiology and cost of herpes zoster and post-herpetic neuralgia in the United Kingdom
    A Gauthier
    i3 Innovus, Uxbridge, Middlesex, UK
    Epidemiol Infect 137:38-47. 2009
  5. ncbi What does epidemiology tell us about risk factors for herpes zoster?
    Sara L Thomas
    Infectious Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Lancet Infect Dis 4:26-33. 2004
  6. pmc The impact of herpes zoster and post-herpetic neuralgia on quality-of-life
    Robert W Johnson
    NSERM U987, Hopital Ambroise Pare, APHP, F 92100 Boulogne Billancourt, France
    BMC Med 8:37. 2010
  7. pmc Similar herpes zoster incidence across Europe: results from a systematic literature review
    Sybil Pinchinat
    Epidemiology Department, Sanofi Pasteur MSD, 8 Rue Jonas Salk, Lyon, 69007, France
    BMC Infect Dis 13:170. 2013
  8. ncbi Efficacy, safety, and tolerability of herpes zoster vaccine in persons aged 50-59 years
    Kenneth E Schmader
    Duke University, North Carolina, USA
    Clin Infect Dis 54:922-8. 2012
  9. pmc Epidemiology of varicella zoster virus infection in Canada and the United Kingdom
    M Brisson
    PHLS CDSC, and City University, London
    Epidemiol Infect 127:305-14. 2001
  10. pmc Herpes zoster and postherpetic neuralgia surveillance using structured electronic data
    Michael Klompas
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
    Mayo Clin Proc 86:1146-53. 2011

Detail Information

Publications304 found, 100 shown here

  1. ncbi A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults
    M N Oxman
    Shingles Prevention Study Mail code 111F 1, VA San Diego Healthcare System, 3350 La Jolla Village Dr, San Diego, CA 92161, USA
    N Engl J Med 352:2271-84. 2005
    The incidence and severity of herpes zoster and postherpetic neuralgia increase with age in association with a progressive decline in cell-mediated immunity to varicella-zoster virus (VZV)...
  2. ncbi Herpes zoster incidence among insured persons in the United States, 1993-2006: evaluation of impact of varicella vaccination
    Jessica Leung
    National Center for Immunization and Respiratory Diseases NCIRD, Centers for Disease Control and Prevention CDC, Atlanta, Georgia 30333, USA
    Clin Infect Dis 52:332-40. 2011
    b>herpes zoster (HZ) is caused by reactivation of latent varicella zoster virus and is often associated with substantial pain and disability...
  3. ncbi A population-based study of the incidence and complication rates of herpes zoster before zoster vaccine introduction
    Barbara P Yawn
    Department of Research, Olmsted Medical Center, 210 Ninth St SE, Rochester, MN, USA
    Mayo Clin Proc 82:1341-9. 2007
    To establish accurate, up-to-date, baseline epidemiological data for herpes zoster (HZ) before the introduction of the recently licensed HZ vaccine.
  4. ncbi Epidemiology and cost of herpes zoster and post-herpetic neuralgia in the United Kingdom
    A Gauthier
    i3 Innovus, Uxbridge, Middlesex, UK
    Epidemiol Infect 137:38-47. 2009
    Recent information on epidemiology and management of herpes zoster (HZ) and post-herpetic neuralgia (PHN), a painful complication of HZ, is scarce...
  5. ncbi What does epidemiology tell us about risk factors for herpes zoster?
    Sara L Thomas
    Infectious Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Lancet Infect Dis 4:26-33. 2004
    Reactivation of latent varicella zoster virus as herpes zoster is thought to result from waning of specific cell-mediated immunity, but little is known about its determinants in individuals with no underlying immunosuppression...
  6. pmc The impact of herpes zoster and post-herpetic neuralgia on quality-of-life
    Robert W Johnson
    NSERM U987, Hopital Ambroise Pare, APHP, F 92100 Boulogne Billancourt, France
    BMC Med 8:37. 2010
    The potentially serious nature of herpes zoster (HZ) and the long-term complication post-herpetic neuralgia (PHN) are often underestimated...
  7. pmc Similar herpes zoster incidence across Europe: results from a systematic literature review
    Sybil Pinchinat
    Epidemiology Department, Sanofi Pasteur MSD, 8 Rue Jonas Salk, Lyon, 69007, France
    BMC Infect Dis 13:170. 2013
    b>Herpes zoster (HZ) is caused by reactivation of the varicella-zoster virus (VZV) and mainly affects individuals aged ≥50 years...
  8. ncbi Efficacy, safety, and tolerability of herpes zoster vaccine in persons aged 50-59 years
    Kenneth E Schmader
    Duke University, North Carolina, USA
    Clin Infect Dis 54:922-8. 2012
    b>Herpes zoster (HZ) adversely affects individuals aged 50-59, but vaccine efficacy has not been assessed in this population...
  9. pmc Epidemiology of varicella zoster virus infection in Canada and the United Kingdom
    M Brisson
    PHLS CDSC, and City University, London
    Epidemiol Infect 127:305-14. 2001
    ..Finally, our results provide baseline estimates of varicella and zoster incidence and morbidity for VZV vaccine effectiveness and cost-effectiveness studies...
  10. pmc Herpes zoster and postherpetic neuralgia surveillance using structured electronic data
    Michael Klompas
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
    Mayo Clin Proc 86:1146-53. 2011
    To develop electronic algorithms for rapid, automated surveillance for herpes zoster and postherpetic neuralgia (PHN) using codified electronic health data.
  11. ncbi The incidence and clinical characteristics of herpes zoster among children and adolescents after implementation of varicella vaccination
    Rachel Civen
    Los Angeles County Department of Public Health, Los Angeles, CA 90011, USA
    Pediatr Infect Dis J 28:954-9. 2009
    The varicella-zoster virus (VZV) vaccine strain may reactivate to cause herpes zoster. Limited data suggest that the risk of herpes zoster in vaccinated children could be lower than in children with naturally acquired varicella...
  12. pmc The impact of herpes zoster and postherpetic neuralgia on health-related quality of life: a prospective study
    Melanie Drolet
    Unité de recherche en santé des populations, Centre Hospitalier Affilie Universitaire De Quebec, Quebec, Que
    CMAJ 182:1731-6. 2010
    Vaccination against herpes zoster is being considered in many countries. We conducted a multicentre prospective study to describe the impact of herpes zoster and postherpetic neuralgia on health-related quality of life.
  13. ncbi Patient perspective on herpes zoster and its complications: an observational prospective study in patients aged over 50 years in general practice
    Didier Bouhassira
    Inserm U987, Centre d Evaluation et de Traitement de la Douleur, Hopital Ambroise Pare, Boulogne Billancourt F 92100, France
    Pain 153:342-9. 2012
    Understanding the effect of herpes zoster and zoster-related pain should inform care to improve health-related quality of life in elderly patients...
  14. ncbi Increased risk of stroke after a herpes zoster attack: a population-based follow-up study
    Jiunn Horng Kang
    Department of Physical Medicine and Rehabilitation, The Neuroscience Research Center, Taipei Medical University Hospital, Taipei, Taiwan
    Stroke 40:3443-8. 2009
    ..This study aims to investigate the frequency and risk of stroke after a herpes zoster attack using a nationwide, population-based study of a retrospective cohort design...
  15. pmc Herpes zoster among persons living with HIV in the current antiretroviral therapy era
    Leah J Blank
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Acquir Immune Defic Syndr 61:203-7. 2012
    Previously, herpes zoster (HZ) was found to occur at a higher rate in the HIV population than the general population...
  16. ncbi Incremental 1-year medical resource utilization and costs for patients with herpes zoster from a set of US health plans
    Ronald R White
    Department of Global Outcomes Research, Global Human Health, West Point, Pennsylvania, USA
    Pharmacoeconomics 27:781-92. 2009
    Nearly 1 million new episodes of herpes zoster (HZ) occur annually in the US, yet little is known about the medical resource utilization (RU) and costs associated with HZ and its complications.
  17. ncbi Modelling the impact of a combined varicella and zoster vaccination programme on the epidemiology of varicella zoster virus in England
    Albert Jan van Hoek
    Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, London NW9 5EQ, UK
    Vaccine 29:2411-20. 2011
    This study updates previous work on modelling the incidence of varicella and Herpes Zoster (HZ) following the introduction of childhood vaccination...
  18. ncbi Acute pain in herpes zoster and its impact on health-related quality of life
    Jennifer Katz
    Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA
    Clin Infect Dis 39:342-8. 2004
    ..on physical and emotional functioning have been examined in a number of studies, the impact of acute pain in herpes zoster ("shingles") on health-related quality of life has been neglected...
  19. pmc Herpes zoster in Germany: quantifying the burden of disease
    Bernhard Ultsch
    Immunization Unit, Robert Koch Institute, 13086 Berlin, Germany
    BMC Infect Dis 11:173. 2011
    b>Herpes zoster (HZ) is caused by a reactivation of the varicella-zoster-virus (VZV) and mainly affects individuals aged≥50 years...
  20. pmc Health care utilization and cost burden of herpes zoster in a community population
    Barbara P Yawn
    Department of Research, Olmsted Medical Center, Rochester, MN 55904, USA
    Mayo Clin Proc 84:787-94. 2009
    To conduct a population-based study to assess health care utilization (HCU) and costs associated with herpes zoster (HZ) and its complications, including postherpetic neuralgia (PHN) and nonpain complications, in adults aged 22 years and ..
  21. ncbi Herpes zoster vaccine in older adults and the risk of subsequent herpes zoster disease
    Hung Fu Tseng
    Department of Research and Evaluation, Kaiser Permanente, Southern California Medical Group, 100 S Los Robles Ave, Second Floor, Pasadena, CA 91101, USA
    JAMA 305:160-6. 2011
    Approximately 1 million episodes of herpes zoster occur annually in the United States...
  22. ncbi Predictors of postherpetic neuralgia among patients with herpes zoster: a prospective study
    Melanie Drolet
    URESP, Centre de Recherche FRSQ du CHA Universitaire de Québec, QC, Canada
    J Pain 11:1211-21. 2010
    Postherpetic neuralgia (PHN) is the most common complication of herpes zoster (HZ). The main objectives of this study were to: 1) estimate the severity and duration of PHN; and 2) identify the predictors of PHN...
  23. ncbi Employment related productivity loss associated with herpes zoster and postherpetic neuralgia: a 6-month prospective study
    Melanie Drolet
    URESP, Centre de Recherche FRSQ du CHA Universitaire de Québec, QC, Canada
    Vaccine 30:2047-50. 2012
    We conducted a prospective multi-center study to assess productivity loss associated with herpes zoster (HZ) and postherpetic neuralgia (PHN)...
  24. ncbi Acute/subacute herpes zoster: healthcare resource utilisation and costs in a group of US health plans
    Ralph P Insinga
    Department of Health Economic Statistics, Merck Research Laboratories, North Wales, Pennsylvania 19454 1099, USA
    Pharmacoeconomics 25:155-69. 2007
    Although there are estimated to be nearly 1 million cases of herpes zoster diagnosed in the US each year, the economic costs associated with herpes zoster in the US have not been well described.
  25. ncbi Does monastic life predispose to the risk of Saint Anthony's fire (herpes zoster)?
    Jacques Gaillat
    Department of Infectious and Tropical Diseases, Annecy General Hospital, Pringy, France
    Clin Infect Dis 53:405-10. 2011
    ..We therefore compared the frequency of herpes zoster in an adult population with virtually no varicella zoster virus (VZV) exposure with that in the general ..
  26. ncbi Contacts with varicella or with children and protection against herpes zoster in adults: a case-control study
    Sara L Thomas
    Infectious Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Lancet 360:678-82. 2002
    ..exposure to varicella-zoster-virus protects individuals with latent varicella-zoster virus infection against herpes zoster by boosting immunity is not known...
  27. ncbi The burden of Herpes Zoster: a prospective population based study
    Fiona T Scott
    Skin Virus Laboratory, Institute for Cell and Molecular Science, 25 29 Ashfield Street, E1 1BB, UK
    Vaccine 24:1308-14. 2006
    ..practices in East London, serving 158,716 patients who presented to their general practitioners with acute Herpes Zoster over an 8-month period...
  28. ncbi A prospective study of the herpes zoster severity of illness
    Melanie Drolet
    Centre Hospitalier Affilie Universitaire De Quebec, Hôpital Saint Sacrement, Quebec, QC, Canada
    Clin J Pain 26:656-66. 2010
    MASTER, a multicenter prospective study, was conducted to provide a thorough understanding of the burden of herpes zoster (HZ) and postherpetic neuralgia (PHN)...
  29. pmc Epidemiology and cost of herpes zoster and postherpetic neuralgia among patients treated in primary care centres in the Valencian community of Spain
    Ana M Cebrián-Cuenca
    Centro de Salud de Ayora, Avenida Argentina, Ayora, Valencia, Spain
    BMC Infect Dis 11:302. 2011
    Data on the epidemiology and costs related to herpes zoster (HZ) and postherpetic neuralgia (PHN) in Spain are scarce; therefore, studies are needed to evaluate the epidemiological and economic impact of HZ and its most common ..
  30. pmc Epidemiology and economic burden of herpes zoster and post-herpetic neuralgia in Italy: a retrospective, population-based study
    Leonardo Emberti Gialloreti
    Dipartimento di Sanita Pubblica, Universita di Roma Tor Vergata, Via Montpellier 1, 00133 Roma, Italy
    BMC Infect Dis 10:230. 2010
    Data on the epidemiology and cost of herpes zoster (HZ) and post-herpetic neuralgia (PHN) in Italy are limited...
  31. pmc Comparing shingles incidence and complication rates from medical record review and administrative database estimates: how close are they?
    Barbara P Yawn
    Research Department, Olmsted Medical Center, 210 Ninth Street SE, Rochester, MN 55904, USA
    Am J Epidemiol 174:1054-61. 2011
    Accurate rates of herpes zoster incidence and complication have become of greater interest as studies have suggested an increasing temporal trend in incidence rates across all age groups and long-term follow-up studies of vaccine ..
  32. ncbi The incidence of, risk factors for, and sequelae of herpes zoster among HIV patients in the highly active antiretroviral therapy era
    Kelly A Gebo
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Acquir Immune Defic Syndr 40:169-74. 2005
    Whereas the incidence, risk factors, and clinical sequelae of herpes zoster have been studied in the general population and in HIV patients in the era before highly active antiretroviral therapy (HAART), they have yet to be fully ..
  33. ncbi Increasing incidence of herpes zoster among Veterans
    David Rimland
    Atlanta Veterans Affairs Medical Center, Decatur, Atlanta, Georgia, USA
    Clin Infect Dis 50:1000-5. 2010
    The incidence of herpes zoster in the United States has been estimated to be > or =1 million cases annually, with a higher rate in adults older than 60 years...
  34. ncbi Risk of herpes zoster in CKD: a matched-cohort study based on administrative data
    Mei Yi Wu
    Department of Nephrology, Shuang Ho Hospital, Taipei Medical University, Taiwan
    Am J Kidney Dis 60:548-52. 2012
    ..Although decreased cellular immunity increases susceptibility to herpes zoster, the risk of herpes zoster in patients with earlier stages of chronic kidney disease (CKD) is unclear.
  35. ncbi The impact of acute herpes zoster pain and discomfort on functional status and quality of life in older adults
    Kenneth E Schmader
    Duke University, Durham, NC, USA
    Clin J Pain 23:490-6. 2007
    To describe the interference of herpes zoster (HZ) pain and discomfort with activities of daily living (ADLs) and health-related quality of life (HRQL) during the acute rash phase, and to quantify the relationship between acute HZ pain ..
  36. ncbi The epidemiological, clinical, and pathological rationale for the herpes zoster vaccine
    Kenneth Schmader
    Center for the Study of Aging and Human Development and Division of Geriatrics, Department of Medicine, Duke University Medical Center, North Carolina, USA
    J Infect Dis 197:S207-15. 2008
    Worldwide, herpes zoster (HZ) affects millions of patients (particularly older adults) annually and causes significant suffering due to acute and chronic pain, or postherpetic neuralgia (PHN)...
  37. ncbi Cost-effectiveness of a vaccine to prevent herpes zoster and postherpetic neuralgia in older adults
    Michael B Rothberg
    Division of General Medicine and Geriatrics, Department of Medicine, Baystate Medical Center, Springfield, MA 01199, USA
    Clin Infect Dis 44:1280-8. 2007
    A vaccine to prevent herpes zoster was recently approved by the United States Food and Drug Administration. We sought to determine the cost-effectiveness of this vaccine for different age groups.
  38. ncbi Clinical practice. Herpes zoster
    John W Gnann
    Departments of Medicine, University of Alabama at Birmingham, Birmingham, Ala 35294 2170, USA
    N Engl J Med 347:340-6. 2002
  39. ncbi Development of a measure of the burden of pain due to herpes zoster and postherpetic neuralgia for prevention trials: adaptation of the brief pain inventory
    Paul M Coplan
    Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    J Pain 5:344-56. 2004
    In preparation for clinical trials of a vaccine against herpes zoster (HZ), we conducted a prospective, observational study to evaluate (1) the Zoster Brief Pain Inventory (ZBPI), an HZ-specific questionnaire to quantify HZ pain and ..
  40. ncbi The incidence of shingles and its implications for vaccination policy
    Rachel S Chapman
    Birmingham Research Unit of the Royal College of General Practitioners, Lordswood House, 54 Lordswood Road, Harborne, Birmingham B17 9DB, UK
    Vaccine 21:2541-7. 2003
    ....
  41. ncbi Herpes zoster: Burden of disease in France
    S Gonzalez Chiappe
    INSERM, U707, F 75012 Paris, France
    Vaccine 28:7933-8. 2010
    ..b>Herpes zoster data was obtained from the Sentinelles surveillance general practitioners (GPs) network, the PMSI Data ..
  42. pmc Herpes zoster risk factors in a national cohort of veterans with rheumatoid arthritis
    Jay R McDonald
    St Louis Veterans Affairs Medical Center, St Louis, Missouri 63106, USA
    Clin Infect Dis 48:1364-71. 2009
    b>Herpes zoster occurs more commonly in patients taking immunosuppressive medications, although the risk associated with different medications is poorly understood.
  43. ncbi Risk of herpes zoster in patients with rheumatoid arthritis treated with anti-TNF-alpha agents
    Anja Strangfeld
    Epidemiology Unit, German Rheumatism Research Center, Chariteplatz 1, 10117 Berlin, Germany
    JAMA 301:737-44. 2009
    ..The risk of bacterial infection is increased in patients treated with drugs that inhibit tumor necrosis factor alpha (TNF-alpha). Little is known about the reactivation of latent viral infections during treatment with TNF-alpha inhibitors...
  44. ncbi Epidemiology of herpes zoster and its relationship to varicella in Japan: A 10-year survey of 48,388 herpes zoster cases in Miyazaki prefecture
    Nozomu Toyama
    Toyama Dermatologic Clinic, Nichinan City, Miyazaki, Japan
    J Med Virol 81:2053-8. 2009
    From 1997 to 2006, a total of 48,388 patients with herpes zoster, ranging from a 3-month-old girl to a 102-year-old woman, were monitored at the 46 dermatology clinics in the Miyazaki Prefecture, which has a population of about 1...
  45. pmc Herpes zoster vaccine effectiveness against incident herpes zoster and post-herpetic neuralgia in an older US population: a cohort study
    Sinead M Langan
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Med 10:e1001420. 2013
    b>Herpes zoster is common and has serious consequences, notably post-herpetic neuralgia (PHN)...
  46. ncbi Herpes zoster in Australia: evidence of increase in incidence in adults attributable to varicella immunization?
    A Jardine
    Public Health Unit, Sydney South West Area Health Service, Camperdown, New South Wales
    Epidemiol Infect 139:658-65. 2011
    Rates of herpes zoster (HZ) hospitalizations, antiviral prescriptions, and New South Wales emergency-department presentations for age groups <20, 20-39, 40-59 and ⩾60 years were investigated...
  47. ncbi Herpes zoster burden of illness and health care resource utilisation in the Australian population aged 50 years and older
    Alicia N Stein
    CSL Limited, 45 Poplar Road, Parkville, Victoria 3052, Australia
    Vaccine 27:520-9. 2009
    ..4 general practitioner consultations. Total costs to the health care system were estimated as approximately 32.8 million per year. The substantial burden of zoster and PHN highlights the potential benefit of zoster vaccination...
  48. pmc Gender difference in the incidence of shingles
    D M Fleming
    Birmingham Research Unit of the Royal College of General Practitioners, 54 Lordswood Road, Harborne, Birmingham B17 9DB, UK
    Epidemiol Infect 132:1-5. 2004
    ..Gender-specific age-standardized incidence rates of shingles were calculated for each year and showed a consistent female excess in each of the 8 years (average annual excess 28%)...
  49. ncbi Predicting and preventing post-herpetic neuralgia: are current risk factors useful in clinical practice?
    Pietro G Coen
    Queen Mary s School of Medicine and Dentistry, University of London, Department of Medical Microbiology, 25 29 Ashfield Street, London E1 1BB, UK
    Eur J Pain 10:695-700. 2006
    Post-herpetic neuralgia (PHN) following acute herpes zoster remains a significant cause of neuropathic pain especially in the elderly...
  50. ncbi European seroepidemiology network 2: Standardisation of assays for seroepidemiology of varicella zoster virus
    Fernando de Ory
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    J Clin Virol 36:111-8. 2006
    ..The aim of the European Sero-Epidemiology Network (ESEN2) is to harmonise the serological surveillance of vaccine-preventable diseases in Europe...
  51. ncbi Epidemiological features and costs of herpes zoster in Taiwan: a national study 2000 to 2006
    Jaw Shyang Jih
    Department of Dermatology, National Yang Ming University, Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan
    Acta Derm Venereol 89:612-6. 2009
    To analyse the epidemiological characteristics and related costs of herpes zoster in Taiwan, a nationally representative cohort of 1,000,000 individuals from the National Health Insurance register was followed up from 2000 to 2006 and ..
  52. pmc Herpes zoster recurrences more frequent than previously reported
    Barbara P Yawn
    Department of Research, Olmsted Medical Center, 210 9th Street SE, Rochester, MN 55904, USA
    Mayo Clin Proc 86:88-93. 2011
    To present population-based estimates of herpes zoster (HZ) recurrence rates among adults.
  53. ncbi Diabetes as a risk factor for herpes zoster infection: results of a population-based study in Israel
    A D Heymann
    Medical Division, Maccabi Healthcare Services, 27 HaMered St, Tel Aviv, 68125, Israel
    Infection 36:226-30. 2008
    ..by impaired cell-mediated immunity, which potentially may increase the risk for infectious diseases, including herpes zoster (HZ). However, data on the relation between DM and HZ are scarce...
  54. ncbi Recommendations for the management of herpes zoster
    Robert H Dworkin
    Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA
    Clin Infect Dis 44:S1-26. 2007
    The objective of this article is to provide evidence-based recommendations for the management of patients with herpes zoster (HZ) that take into account clinical efficacy, adverse effects, impact on quality of life, and costs of ..
  55. pmc Risk of Herpes zoster in patients with underlying diseases: a retrospective hospital-based cohort study
    A Hata
    Department of Infectious Diseases, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, 2 4 20, Ohgimachi, Kita ku, Osaka 530 8480, Japan
    Infection 39:537-44. 2011
    To determine the incidence of Herpes zoster in patients with one of 17 specific underlying diseases compared with that in patients with other underlying diseases.
  56. ncbi The incidence of varicella and herpes zoster in Taiwan during a period of increasing varicella vaccine coverage, 2000-2008
    D Y Chao
    Graduate Institute of Microbiology and Public Health, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan
    Epidemiol Infect 140:1131-40. 2012
    ..However the vaccine's long-term impact on the incidence of herpes zoster (HZ) has attracted attention...
  57. ncbi The health and economic burden of chickenpox and herpes zoster in Belgium
    J Bilcke
    Center for Health Economic Research and Modeling Infectious Diseases, Vaccine and Infectious Disease Institute VAXINFECTIO, University of Antwerp, Universiteitsplein 1, Wilrijk, Belgium
    Epidemiol Infect 140:2096-109. 2012
    Varicella-zoster virus causes chickenpox (CP) and after reactivation herpes zoster (HZ). Vaccines are available against both diseases warranting an assessment of the pre-vaccination burden of disease...
  58. ncbi The cost-effectiveness of varicella and combined varicella and herpes zoster vaccination programmes in the United Kingdom
    Albert Jan van Hoek
    Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, LondonNW9 5EQ, UK
    Vaccine 30:1225-34. 2012
    ..countries have not introduced it into their national schedules, partly because of concerns about whether herpes zoster (HZ, shingles) will increase due to a lack of exogenous boosting...
  59. ncbi Risk of herpes zoster in patients treated with long-term hemodialysis: a matched cohort study
    Chien Chun Kuo
    Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Taiwan
    Am J Kidney Dis 59:428-33. 2012
    The risk of herpes zoster in the dialysis population relative to the general population is not known...
  60. ncbi Exposure to varicella boosts immunity to herpes-zoster: implications for mass vaccination against chickenpox
    M Brisson
    Immunisation Division, PHLS Communicable Disease Surveillance Centre, London, UK
    Vaccine 20:2500-7. 2002
    ..Mass varicella vaccination is expected to cause a major epidemic of herpes-zoster, affecting more than 50% of those aged 10-44 years at the introduction of vaccination...
  61. pmc Risk of herpes zoster among patients with chronic obstructive pulmonary disease: a population-based study
    Ya Wen Yang
    Department of Dermatology, School of Medicine, College of Medicine, Taipei Medical University, Taiwan
    CMAJ 183:E275-80. 2011
    ..in chronic obstructive pulmonary disease (COPD) is hypothesized to predispose patients to development of herpes zoster. However, the risk of herpes zoster among patients with COPD is undocumented...
  62. ncbi Contacts with children and young people and adult risk of suffering herpes zoster
    M Salleras
    Dermatology Department, Sagrado Corazón Hospital, Barcelona, Spain
    Vaccine 29:7602-5. 2011
    ..Cases of herpes zoster in immunocompetent healthy patients aged ≥ 25 years seen in the dermatology department of the Sagrado Corazó..
  63. ncbi Postherpetic neuralgia: epidemiology, pathophysiology and management
    Robert W Johnson
    Bristol Royal Infirmary, University of Bristol, Bristol, UK
    Expert Rev Neurother 7:1581-95. 2007
    Postherpetic neuralgia (PHN) is a neuropathic pain syndrome and is the most common complication of herpes zoster (HZ; shingles)...
  64. ncbi VZV T cell-mediated immunity
    Adriana Weinberg
    University of Colorado Denver, Aurora, CO 80045, USA
    Curr Top Microbiol Immunol 342:341-57. 2010
    ..these responses decline, as occurs with aging or iatrogenic immune suppression, reactivation of VZV leads to herpes zoster. Similarly, the magnitude of these responses early after the onset of herpes zoster correlates with the extent ..
  65. ncbi Systemic absorption of topical lidocaine in normal volunteers, patients with post-herpetic neuralgia, and patients with acute herpes zoster
    Bryan J Campbell
    Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Pharm Sci 91:1343-50. 2002
    ..and gel formulations in normal volunteers, patients with post-herpetic neuralgia, and patients with acute herpes zoster. The bioavailability of lidocaine from the patch formulation averaged 3%, and was similar after single and ..
  66. ncbi Herpes zoster and postherpetic neuralgia: incidence and risk indicators using a general practice research database
    Wim Opstelten
    Julius Center for General Practice and Patient Oriented Research, University Medical Center Utrecht, PO Box 85060, 3500 AB Utrecht, The Netherlands
    Fam Pract 19:471-5. 2002
    Postherpetic neuralgia (PHN) is a frequent complication of herpes zoster (HZ). Treatment results of this severe and long-lasting pain syndrome are often disappointing...
  67. ncbi Insulin degrading enzyme is a cellular receptor mediating varicella-zoster virus infection and cell-to-cell spread
    Qingxue Li
    Laboratory of Clinical Infectious Diseases, Medical Virology Section, National Institutes of Health, Bethesda, MD, 20892 USA
    Cell 127:305-16. 2006
    ..These studies indicate that IDE is a cellular receptor for both cell-free and cell-associated VZV...
  68. pmc Varicella-zoster virus transfer to skin by T Cells and modulation of viral replication by epidermal cell interferon-alpha
    Chia Chi Ku
    Department of Pediatrics, Stanford University, School of Medicine, Stanford, CA 94305, USA
    J Exp Med 200:917-25. 2004
    ..Modulation of VZV replication by cutaneous innate immunity may avoid an incapacitating infection of the host that would limit opportunities for VZV transmission...
  69. ncbi Herpes zoster and postherpetic neuralgia: prevention and management
    Julia Fashner
    Saint Joseph Family Medicine Residency Program, South Bend, IN 46617, USA
    Am Fam Physician 83:1432-7. 2011
    b>Herpes zoster (shingles) is diagnosed clinically by recognition of the distinctive, painful vesicular rash appearing in a unilateral, dermatomal distribution...
  70. ncbi A study of shingles and the development of postherpetic neuralgia in East London
    Fiona T Scott
    Department of Medical Microbiology, Medical and Dental School, Queen Mary College, 25 29 Ashfield Street, London E1 1BB, England, UK
    J Med Virol 70:S24-30. 2003
    ..More accurate prediction of which subset of elderly patients are most at risk of PHN may enable targeted prescribing of the most potent drugs to those most likely to benefit...
  71. ncbi Assessment of transcriptomal analysis of Varicella-Zoster-virus gene expression in patients with and without post-herpetic neuralgia
    G H Ashrafi
    Department of Neurology, Division of Clinical Neurosciences, Institute of Neurological Sciences, Southern General Hospital, Glasgow, Scotland, UK
    Virus Genes 41:192-201. 2010
    ..a human herpes virus that reactivates from a latent state in human trigeminal and dorsal root ganglia to cause herpes zoster (shingles) which is a painful vesicular dermatomal skin eruption...
  72. ncbi Cutaneous metastatic rectal carcinoma masquerading as herpes zoster
    Jessica Eichinger
    San Antonio Military Medical Center South, San Antonio, TX 78236, USA
    South Med J 104:233-5. 2011
    ..Physicians providing care to patients with a history of cancer should maintain a high clinical suspicion for cutaneous metastases in patients with new or evolving skin conditions...
  73. ncbi [Herpes zoster: incidence study among "sentinel" general practitioners]
    S Czernichow
    , , Paris, France
    Ann Dermatol Venereol 128:497-501. 2001
    INTRODUCTION: Herpes zoster is a frequent disease but its incidence in France is unknown. METHODS: We conducted a postal survey among the general practitioners of the "Sentinel" network...
  74. ncbi Extensive cutaneous larva migrans with folliculitis mimicking multimetameric herpes zoster presentation in an adult traveler returning from Thailand
    Denis Malvy
    Travel Clinics and Tropical Disease Unit, Department of Internal Medicine, Infectious Diseases and Tropical Medicine, University Hospital Center, Bordeaux, France
    J Travel Med 13:244-7. 2006
    ..Simple anamnestic information--often revealing beach activities--and clinical aspect of the creeping eruption allow to prevent diagnosis delay and to avoid aggressive or inadequate intervention...
  75. ncbi Willingness to pay for a QALY based on community member and patient preferences for temporary health states associated with herpes zoster
    Tracy A Lieu
    Department of Ambulatory Care and Prevention, Harvard Pilgrim Health Care and Harvard Medical School, Boston, Massachusetts 02215, USA
    Pharmacoeconomics 27:1005-16. 2009
    ..had the opportunity to evaluate WTP per QALY using data from a survey on temporary health outcomes related to herpes zoster. Our aims were to (i) describe how much community members are willing to pay to save a QALY based on scenarios ..
  76. ncbi Herpes zoster in HIV-1-infected patients in the era of highly active antiretroviral therapy: a prospective observational study
    Chien Ching Hung
    Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, 7 Chung Shan South Road, Taipei, Taiwan
    Int J STD AIDS 16:673-6. 2005
    ..differentiation CD4+ count of 61 x 10(6) cells/L (range, 1-1206 x 10(6) cells/L) developed 103 episodes of herpes zoster [HZ], with an incidence of 5.67 per 100 person-years (PY)...
  77. ncbi Seroprevalence of varicella-zoster virus in Korea
    Won Suk Choi
    Division of Infectious Disease, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
    J Med Virol 82:2123-6. 2010
    Varicella-zoster virus (VZV) causes chickenpox and herpes zoster. Korea is assumed to have a high seroprevalence of VZV, although data are scant...
  78. pmc Wet cupping therapy for treatment of herpes zoster: a systematic review of randomized controlled trials
    Huijuan Cao
    Beijing University of Chinese Medicine
    Altern Ther Health Med 16:48-54. 2010
    Wet cupping is a traditional Chinese medicine therapy commonly used in treating herpes zoster in China, and clinical studies have shown that wet cupping may have beneficial effect on herpes zoster compared with Western medication.
  79. pmc Productive varicella-zoster virus infection of cultured intact human ganglia
    Kavitha Gowrishankar
    Center for Virus Research, Westmead Millenium Institute, and Department of Infectious Diseases and Immunology, University of Sydney, Blackburn Building, 2006 NSW, Australia
    J Virol 81:6752-6. 2007
    ..This model enables VZV infection of ganglionic cells to be studied in the context of intact DRG...
  80. pmc Burden of herpes zoster requiring hospitalization in Spain during a seven-year period (1998-2004)
    Angel Gil
    Department of Health Sciences, Rey Juan Carlos University, Avda de Atenas s n, 28922 Alcorcon, Madrid, Spain
    BMC Infect Dis 9:55. 2009
    ..A population-based retrospective epidemiological study to estimate the burden of herpes zoster requiring hospitalization in Spain was conducted.
  81. ncbi The comparative sero-epidemiology of varicella zoster virus in 11 countries in the European region
    A Nardone
    Health Protection Agency, Centre for Infections, London, UK
    Vaccine 25:7866-72. 2007
    ..There are substantial differences in VZV sero-epidemiology within the European region, which will need to be taken into account in designing national policies regarding VZV vaccination...
  82. pmc Predictors of pain intensity and persistence in a prospective Italian cohort of patients with herpes zoster: relevance of smoking, trauma and antiviral therapy
    Giustino Parruti
    Infectious Disease Unit, Pescara General Hospital, Pescara, Italy
    BMC Med 8:58. 2010
    b>Herpes zoster (HZ) is a common disease, characterized by rash-associated localized pain. Its main complication, post-herpetic neuralgia (PHN), is difficult to treat and may last for months to years in the wake of rash resolution...
  83. pmc Varicella-zoster virus
    A M Arvin
    Department of Pediatrics, Stanford University School of Medicine, California 94305 5119, USA
    Clin Microbiol Rev 9:361-81. 1996
    Varicella-zoster virus (VZV) is a ubiquitous human alphaherpesvirus that causes varicella (chicken pox) and herpes zoster (shingles)...
  84. pmc Varicella-zoster virus-specific immune responses to herpes zoster in elderly participants in a trial of a clinically effective zoster vaccine
    Adriana Weinberg
    University of Colorado Denver, Denver, CO, USA
    J Infect Dis 200:1068-77. 2009
    ..were to evaluate the association between varicella-zoster virus (VZV)-specific humoral and cell-mediated immunity (CMI) to herpes zoster (HZ) and protection against HZ morbidity and to compare immune responses to HZ and zoster vaccine.
  85. ncbi The role of sympathetic nerve blocks in herpes zoster and postherpetic neuralgia
    C L Wu
    The Johns Hopkins Hospital, Department of Anesthesiology and Critical Care Medicine, Division of Pain Medicine, 550 N Broadway, Suite 301, Baltimore, MD 21205, USA
    Pain 87:121-9. 2000
    The most common complication of herpes zoster in immunocompetent patients is postherpetic neuralgia (PHN)...
  86. ncbi Herpes simplex virus-1 and varicella-zoster virus latency in ganglia
    Bradley M Mitchell
    Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA
    J Neurovirol 9:194-204. 2003
    ..For each virus, remaining questions and future studies to understand the mechanism of latency are discussed with respect to prevention of serious cutaneous, ocular, and neurologic disease produced by virus reactivation...
  87. ncbi Advances in the understanding of the pathogenesis and epidemiology of herpes zoster
    Anne A Gershon
    Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Clin Virol 48:S2-7. 2010
    ..root ganglia during varicella and, when reactivated, travels along the sensory nerve axons to cause shingles (herpes zoster [HZ])...
  88. ncbi Herpes zoster pathogenesis and cell-mediated immunity and immunosenescence
    Michael N Oxman
    University of California, San Diego, Staff Physician Infectious Diseases, VA San Diego Healthcare System, San Diego, CA 92161 0001, USA
    J Am Osteopath Assoc 109:S13-7. 2009
    b>Herpes zoster, or shingles, is a localized disease characterized by unilateral radicular pain and a vesicular rash limited to the area of skin innervated by a single dorsal root or cranial sensory ganglion...
  89. ncbi Herpes zoster and postherpetic neuralgia: optimizing management in the elderly patient
    Robert W Johnson
    Bristol Royal Infirmary and University of Bristol, Bristol, United Kingdom
    Drugs Aging 25:991-1006. 2008
    b>Herpes zoster (HZ) results from reactivation of varicella-zoster virus (VZV) that has been persistent and clinically dormant in spinal ganglia or cranial sensory nerves since primary infection with VZV...
  90. pmc Prevalence of postherpetic neuralgia after a first episode of herpes zoster: prospective study with long term follow up
    S Helgason
    Arbaer Health Care Centre, IS 110 Reykjavik, Iceland S Helgason
    BMJ 321:794-6. 2000
    To estimate the frequency, duration, and clinical importance of postherpetic neuralgia after a single episode of herpes zoster.
  91. ncbi The epidemiology of varicella and herpes zoster in The Netherlands: implications for varicella zoster virus vaccination
    Hester de Melker
    Centre for Infectious Disease Epidemiology, National Institute of Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Vaccine 24:3946-52. 2006
    We studied the epidemiology of varicella (chickenpox) and herpes zoster (shingles) in The Netherlands to assess the desirability to implement routine varicella zoster virus vaccination in The Netherlands...
  92. ncbi Increased risk of Guillain-Barré Syndrome following recent herpes zoster: a population-based study across Taiwan
    Jiunn Horng Kang
    Departments of 1Physical Medicine and Rehabilitation and 2Neurology, 3Neuroscience Research Center, and 4School of Health Care Administration, Taipei Medical University, Taipei, Taiwan
    Clin Infect Dis 51:525-30. 2010
    Guillain-Barré syndrome (GBS) has been sporadically reported to be associated with herpes zoster reactivation. However, the risk for developing GBS after herpes zoster reactivation remains unknown...
  93. ncbi Varicella zoster virus: review of its management
    M B Mustafa
    Oral Medicine Section, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Khartoum, Khartoum, Sudan
    J Oral Pathol Med 38:673-88. 2009
    ..The first choice of any of these medications should be guided by the patient's medical health, the likely adverse effects of the drug and the patient's preference...
  94. pmc Herpes zoster
    David W Wareham
    Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry
    BMJ 334:1211-5. 2007
  95. ncbi Herpes zoster vaccination among adults aged 60 years or older in the United States, 2007: uptake of the first new vaccine to target seniors
    Peng Jun Lu
    National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Vaccine 27:882-7. 2009
    Approximately one million new cases of shingles (herpes zoster [HZ]), a severely painful and debilitating disease caused by reactivation of varicella-zoster virus (VZV), occur in the United States each year...
  96. ncbi Spinal cord stimulation in postherpetic neuralgia and in acute herpes zoster pain
    Henning Harke
    Department of Anesthesia and Pain Therapy, Klinikum Krefeld, Krefeld, Germany
    Anesth Analg 94:694-700; table of contents. 2002
    ..In addition, four patients with acute herpes zoster (HZ) pain were studied simultaneously...
  97. ncbi Herpes zoster guidelines of the German Dermatological Society
    G Gross
    J Clin Virol 27:308-9. 2003
  98. ncbi Herpes Zoster mimicking recurrence of lymphoma on PET/CT
    Judith M Joyce
    Division of Nuclear Medicine, Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Clin Nucl Med 31:104-5. 2006
  99. ncbi Cutaneous multifocal melanoma metastases clinically resembling herpes zoster
    K Kondras
    J Eur Acad Dermatol Venereol 20:470-2. 2006
  100. ncbi Herpes zoster vaccination among adults aged 60 years and older, in the U.S., 2008
    Peng Jun Lu
    National Center for Immunization and Respiratory Diseases, CDC, Atlanta, GA, USA
    Am J Prev Med 40:e1-6. 2011
    Shingles (herpes zoster [HZ]) is a localized, generally painful and debilitating disease that occurs most frequently among older adults. It is caused by reactivation of varicella-zoster virus...
  101. ncbi Successful IL-2 therapy for relapsing herpes zoster infection in a patient with idiopathic CD4+ T lymphocytopenia
    K Warnatz
    Department of Internal Medicine, University Hospital Freiburg, Germany
    Immunobiology 202:204-11. 2000
    ..Here we describe a 65-year old patient with relapsing generalized herpes zoster infection due to ICL and a severe panlymphocytopenia...

Research Grants62

  1. VZV BACs: New Tools for Pathogenesis Research
    Nikolaus Osterrieder; Fiscal Year: 2005
    Varicella zoster virus (VZV) causes chickenpox (varicella) and shingles (herpes zoster)...
  2. Cdk inhibitors: novel antivirals for VZV
    Jennifer Moffat; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Immunocompromised individuals are at high risk for herpes zoster caused by reactivation of varicella zoster virus (VZV)...
  3. Tomotherapy and Hematopoietic Stem Cells For Tolerance to Kidney Transplants
    Samuel Strober; Fiscal Year: 2013
    ..antibody responses to influenza virus vaccination after transplantation, as well as recall T cell responses to herpes zoster, herpes simplex, cytomegalovirus antigens, and tetanus toxoid...
  4. Varicella zoster virus-Induced Pain in a Rat Model of Post-Herpetic Neuralgia
    Paul R Kinchington; Fiscal Year: 2013
    Post-Herpetic Neuralgia (PHN) is a common and exceedingly painful complication of herpes zoster that is debilitating, intractable, long-lasting and difficult to treat...
  5. Vitamin D and Immunosenescence in Older Long-Term Care Residents
    Adit A Ginde; Fiscal Year: 2013
    ..and Pediatrics at UCD, whose research has focused on characterizing and improving response to influenza and herpes zoster vaccines...
  6. The molecular pathogenesis of varicella zoster virus infection
    Donald Gilden; Fiscal Year: 2013
    ..With aging, a declining cell-mediated immunity to VZV leads to virus reactivation, manifesting as herpes zoster (shingles) characterized by pain and rash restricted to 1-3 dermatomes...
  7. Vaccination and infection: indicators of immunological health and responsiveness
    MARK MORRIS DAVIS; Fiscal Year: 2013
    ..across a range of different vaccines including influenza, both seasonal and the new pandemic H1N1v, Herpes zoster, Measles, and the bacterium Neisseria meningitidis...
  8. A new in vitro neuron model of axonal transport and persistence of varicella zost
    Paul R Kinchington; Fiscal Year: 2013
    ..site of a decades-long state of persistence, from which VZV can reactivate to cause the debilitating disease Herpes zoster. VZV remains a major source of human morbidity, even in an age of commercial vaccines, as most adults harbor ..
  9. Civamide Nasal Spray for the Treatment of Postherpetic Neuralgia of the Trigemina
    Scott B Phillips; Fiscal Year: 2013
    ..25,26 PHN of the [TN] is a chronic condition characterized by extreme pain following herpes zoster infection, (commonly called shingles,) in the areas of the face and scalp which are innervated by the [TN]...
  10. Zoster Vaccine and Risk Factors of Zoster and Post-Herpetic Neuralgia
    HUNGFU TSENG; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Herpes zoster (HZ), or shingles, is a painful vesicular rash, usually unilateral, caused by the varicella zoster virus (VZV)...
  11. Impact of immune senescence on herpes zoster in a nonhuman primate model
    Ilhem Messaoudi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Reactivation of latent varicella zoster virus (VZV) leads to herpes zoster (HZ, also known as shingles), a disease that causes major morbidity and occasionally mortality in older individuals...
  12. Risk of Herpes Zoster Among Adults with Asthma
    Young J Juhn; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Herpes zoster (HZ) or shingles is a serious health problem occurring in one of three adults during their life time, nearly one million cases a year in the United States...
  13. ANTIGENIC DETERMINANTS OF VARICELLA VIRUS
    Charles Grose; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Varicella-zoster virus (VZV) is the cause of chickenpox and herpes zoster. VZV infection is a recurrent problem in both transplant and cancer patients...
  14. Varicella Active Surveillance Project
    Laurene Mascola; Fiscal Year: 2010
    ..We propose to continue varicella and herpes zoster (HZ) active surveillance and extend the project to the city of Santa Clarita to increase the population to ..
  15. DEFINITION OF THE CHRONIC EPSTEIN-BARR VIRUS SYNDROME
    James Jones; Fiscal Year: 1990
    ..Symptom scores, family history records, antibody titers to EBV antigens, adenovirus, herpes zoster, influenza A, herpes simplex, cytomegalovirus, Mycoplasma pneumoniae and EBV virus excretion will be measured...
  16. PATHOPHYSIOLOGY OF VARICELLA ZOSTER VIRUS INFECTION
    Martin Myers; Fiscal Year: 1980
    ..Clinical and pathologic studies of patients with herpes zoster have implicated the sensory neuroganglia as a probable site of persistent viral infection...
  17. SYNTHETIC MASKED NUCLEOSIDES FOR ANTICANCER STUDIES
    Kyoichi Watanabe; Fiscal Year: 1992
    ..FIAC, underwent Phase I and II clinical trials and proved to be superior to ara-A for the treatment of Herpes zoster infections in immunosuppressed cancer patients, and (c) another nucleoside, FMAU, exhibited even more potent ..
  18. Novel Topical Treatment for Postherpetic Neuralgia
    Charles Gauntt; Fiscal Year: 2005
    ..PHN is defined as pain in the affected dermatome that persists or appears after the rash of herpes zoster (HZ) has healed...
  19. Analgesia in Herpes Zoster and Postherpetic Neuralgia
    Robert Dworkin; Fiscal Year: 2001
    b>Herpes zoster is a common and painful neurological disease that is caused by reactivation of the varicella-zoster virus...
  20. PAIN & NEURAL DYSFUNCTION FROM ACUTE HERPES ZOSTER
    Karin Petersen; Fiscal Year: 2003
    Pain, nerve trunk inflammation, and neuronal injury are hallmarks of acute herpes zoster (AHZ or 'shingles')...
  21. Zeiss LSM 510-NLO multiphoton laser scanning microscope
    Joseph Mazurkiewicz; Fiscal Year: 2003
    ..cutaneous innervation in normal and pathologic skin to study pain and neural dysfunction resulting from Herpes Zoster using mutiply-fluorescent-labeled thick samples of human skin. Dr...
  22. OCULAR & OTHER VARICELLA/ZOSTER DISEASE IN MODELS
    EDMUND DUNKEL; Fiscal Year: 1993
    ..Varicella is the most common infectious disease in the USA. Reactivated "latent" VZV infection, herpes zoster, is a widespread, often debilitating disease especially in the elderly or immunocompromised patient...
  23. TAI CHI CHIH AND VARICELLA ZOSTER IMMUNITY
    Michael Irwin; Fiscal Year: 2001
    Both the incidence and severity of herpes zoster (HZ) or shingles increase markedly with increasing age due to a decline in varicella zoster virus (VZV) specific immunity...
  24. SYMPATHETIC EFFERENT MODULATION OF PAIN
    William Roberts; Fiscal Year: 1993
    ..the physiology of sympathetically dependent pain, such as that in reflex sympathetic dystrophy, acute herpes zoster and some cases of low back pain...
  25. HERPES ZOSTER: THERAPY AND PROPHYLAXIS IN HIV INFECTION
    Kathleen Brady; Fiscal Year: 2004
    ..The research component will focus on herpes zoster in the HIV-infected host...
  26. VZV Receptors and Infective Mechanisms
    Anne Gershon; Fiscal Year: 2007
    ..It may also make it possible to develop a safer and more efficacious vaccine. ..
  27. PEDIATRICS AIDS CLINICAL TRIALS GROUP
    Anne Gershon; Fiscal Year: 2006
    ..We have competent, outstanding staff whose aim is not only to provide compassionate medical care to HIV-infected patients but also to perform meaningful and useful research on prevention and treatment of HIV infection. ..
  28. Herpes Zoster and Medications in the Elderly
    Kenneth Schmader; Fiscal Year: 2005
    ..VA Medical Centers with a strong commitment, funding and publication record in patient-oriented research in herpes zoster and medications in the elderly and a history of mentoring house staff and junior faculty in clinical research...
  29. ONTOGENY OF MEASLES IMMUNITY IN INFANTS
    Ann Arvin; Fiscal Year: 2006
    ..Understanding the maturation of host responses to viral antigens during the first year of life has general relevance for vaccine strategies in infancy. ..
  30. Neurite density in skin as a marker for neuropathic pain
    Anne Louise Oaklander; Fiscal Year: 2005
    ..in adults with one of two common neuropathic pain conditions, postherpetic neuralgia (PHN) after shingles (herpes zoster), or painful neuropathy in the lower legs from diabetes mellitus, and in rat models of these conditions...
  31. Varicella and Herpes Zoster after Varicella Vaccination
    SHEILA WIENMANN; Fiscal Year: 2008
    ..In addition, herpes zoster after vaccination is not uncommon, and vaccine-type varicella virus has been isolated from some cases...
  32. Sleep and Immune Mechanisms in Rheumatoid Arthritis
    Michael Irwin; Fiscal Year: 2009
    ..Results from this study will guide the development of interventions that target disordered sleep with potential effects on disability in RA. ..
  33. Gene Expression in Acute and Chronic Neurologic Disease
    Donald Gilden; Fiscal Year: 2008
    ..This concerted effort is focused on prospective studies to delineate the cause, pathogenesis and eventual prevention of viral and demyelinating diseases of the human nervous system. ..
  34. Tai Chi Effects on Chronic Insomnia in Breast Cancer Survivors: Immune Mechanisms
    Michael R Irwin; Fiscal Year: 2010
    ..This project will constitute the first, randomized controlled clinical trial of the effects of TCC on sleep outcomes in breast cancer survivors, and will advance psychobiological models of insomnia treatment mechanisms. ..
  35. BEHAVIORAL INTERVENTION FOR HERPES ZOSTER RISK IN AGING
    Michael Irwin; Fiscal Year: 2003
    Description (adapted from investigator's abstract): The incidence and severity of herpes zoster (HZ) or shingles increase markedly with increasing age due to a decline in varicella zoster virus (VZV) specific immunity...
  36. DEPRESSION AND TRIAL OF VARICELLA VACCINE IN THE ELDERLY
    Michael Irwin; Fiscal Year: 2003
    ..much evidence indicates that cell mediated immunity plays a critical role in limiting the occurrence of herpes zoster (HZ) and its complications, the effect of major depression on VZV-specific cellular immunity will be examined...
  37. RESEARCH PERSPECTIVES IN PNI, TRAINEE TRAVEL
    Michael Irwin; Fiscal Year: 2006
    ..abstract_text> ..
  38. Cocaine Dependence: EEG Sleep and Cytokines
    Michael Irwin; Fiscal Year: 2005
    ..abstract_text> ..
  39. Alcoholism: Sleep and Cytokines in African Americans
    Michael Irwin; Fiscal Year: 2005
    ..g., cytokine antagonists) for sleep disturbance in alcoholism. ..
  40. Mechanisms of chemotherapy-evoked neuropathic pain
    Gary Bennett; Fiscal Year: 2009
    ....
  41. NEUROPATHIC PAIN FROM AN EXPERIMENTAL NEURITIS
    Gary Bennett; Fiscal Year: 2002
    ..Electrophysiological recordings from identified sensory axons will determine if abnormal discharge arises at the site of inflammation and if there is peripheral sensitization due to an antidromically-conducted ectopic discharge. ..
  42. Respiratory Viruses and Airflow Obstruction after HCT
    Michael Boeckh; Fiscal Year: 2008
    ..These studies will improve our understanding of the interaction between respiratory viruses and late pulmonary complications after HCT, which will ultimately enable us to formulate more rational treatment strategies. ..
  43. Genetic Resistance to Oncogenic Human Papillomaviruses
    Stephen Tyring; Fiscal Year: 2004
    ..Thus, this study is an important step in the development of an HPV vaccine to prevent infection. ..
  44. Functional Senescence of Innate Immunity and Pneumonia
    Kevin High; Fiscal Year: 2003
    ..These data are essential to design meaningful studies using the case-control method, the most effective means of studying the link between immune senescence and infection risk. ..
  45. DIETARY FATTY CONTROL OF INFLAMMATION
    Kevin High; Fiscal Year: 2002
    ..Health relateness: Answering these fundamental questions will shed critical light on the feasibility of utilizing dietary fatty acids to regulate AA metabolism and related clinical disorders. ..
  46. Brucella, Aging and Role of IL-17 in Host Defense
    Kevin High; Fiscal Year: 2005
    ..The data generated in this proposal will form the foundation of future R01 proposals aimed at enhancing immunity vs. intracellular pathogens in our aging population. ..
  47. Animal models to design & evaluate improved VZV vaccines
    WAYNE GRAY; Fiscal Year: 2007
    ..The virus may reactivate later in life to cause herpes zoster (shingles) and postherpetic neuralgia...
  48. Mammographic Density in a Multi-Ethnic Cohort
    Laurel Habel; Fiscal Year: 2005
    ..abstract_text> ..
  49. INTEGRATE/PHARMACOKINETIC/ANTIRETROVIRUS RESISTANCE TEST
    Edward Acosta; Fiscal Year: 2006
    ..abstract_text> ..
  50. Pathogen-specific T cell responses in patients with SLE
    Insoo Kang; Fiscal Year: 2008
    ..Of interest, studies reported an increased frequency of herpes zoster due to reactivation of varicella zoster virus (VZV) in patients with SLE and increased EBV viral loads in ..
  51. Developmental Disabilities in a Time of AIDS
    ADHIKARI MIRIAM; Fiscal Year: 2004
    ..abstract_text> ..
  52. CHRONIC NEUROPATHIC PAIN MECHANISMS AND MANAGEMENT
    Michael Rowbotham; Fiscal Year: 2004
    ..Project II will test the hypothesis that development of chronic post-herpetic neuralgia after herpes zoster strongly depends on the severity of the initial neural injury and the quality of neural recovery...
  53. Compressed Autoantibody Induction Heralding Autoimmunity
    Andreas Reimold; Fiscal Year: 2006
    ..The gene expression signatures of autoantibody induction that emerges from this study will characterize the earliest stages of autoimmune disease induction. ..
  54. DCIS--MAMMOGRAPHIC FEATURES AND PROGNOSIS
    Laurel Habel; Fiscal Year: 2003
    ..abstract_text> ..
  55. Development of the enteric nervous system: Cells & genes
    Michael Gershon; Fiscal Year: 2006
    ..The invited speakers include all of the leading researchers in the field, including Professor Nicole Le Douarin. We also anticipate that many post-graduate students and post-doctoral fellows will also attend. [unreadable] [unreadable]..
  56. Epidemiology of Recurrent Aphthous Stomatitis
    Lorena Baccaglini; Fiscal Year: 2007
    ..Understanding the cause of canker sores can lead to better treatments for patients affected by this condition. [unreadable] [unreadable] [unreadable]..
  57. Macrophage defense againt M. tuberculosis
    Jennifer Wang; Fiscal Year: 2008
    ..abstract_text> ..
  58. Investigating aging and membrane-associated T cell receptor signaling in human CD
    Insoo Kang; Fiscal Year: 2008
    ..The results of this study will provide important information on enhancing immune responses in the aged populations, leading to improved protection against infections and tumors. [unreadable] [unreadable] [unreadable]..
  59. ROLE OF VARICELLA ZOSTER VIRUS GLYCOPROTEIN B DURING VIR
    THOMAS HEINEMAN; Fiscal Year: 2003
    ..This research may identify critical viral metabolic pathways and may ultimately lead to the development of new antiviral therapies. ..