Genomes and Genes
Summary: An acute infectious, usually self-limited, disease believed to represent activation of latent varicella-zoster virus (HERPESVIRUS 3, HUMAN) in those who have been rendered partially immune after a previous attack of CHICKENPOX. It involves the SENSORY GANGLIA and their areas of innervation and is characterized by severe neuralgic pain along the distribution of the affected nerve and crops of clustered vesicles over the area. (From Dorland, 27th ed)
Publications304 found, 100 shown here
- A vaccine to prevent herpes zoster and postherpetic neuralgia in older adultsM N Oxman
Shingles Prevention Study Mail code 111F 1, VA San Diego Healthcare System, 3350 La Jolla Village Dr, San Diego, CA 92161, USA
N Engl J Med 352:2271-84. 2005The incidence and severity of herpes zoster and postherpetic neuralgia increase with age in association with a progressive decline in cell-mediated immunity to varicella-zoster virus (VZV)...
- Herpes zoster incidence among insured persons in the United States, 1993-2006: evaluation of impact of varicella vaccinationJessica Leung
National Center for Immunization and Respiratory Diseases NCIRD, Centers for Disease Control and Prevention CDC, Atlanta, Georgia 30333, USA
Clin Infect Dis 52:332-40. 2011b>herpes zoster (HZ) is caused by reactivation of latent varicella zoster virus and is often associated with substantial pain and disability...
- A population-based study of the incidence and complication rates of herpes zoster before zoster vaccine introductionBarbara P Yawn
Department of Research, Olmsted Medical Center, 210 Ninth St SE, Rochester, MN, USA
Mayo Clin Proc 82:1341-9. 2007To establish accurate, up-to-date, baseline epidemiological data for herpes zoster (HZ) before the introduction of the recently licensed HZ vaccine.
- Epidemiology and cost of herpes zoster and post-herpetic neuralgia in the United KingdomA Gauthier
i3 Innovus, Uxbridge, Middlesex, UK
Epidemiol Infect 137:38-47. 2009Recent information on epidemiology and management of herpes zoster (HZ) and post-herpetic neuralgia (PHN), a painful complication of HZ, is scarce...
- What does epidemiology tell us about risk factors for herpes zoster?Sara L Thomas
Infectious Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
Lancet Infect Dis 4:26-33. 2004Reactivation of latent varicella zoster virus as herpes zoster is thought to result from waning of specific cell-mediated immunity, but little is known about its determinants in individuals with no underlying immunosuppression...
- The impact of herpes zoster and post-herpetic neuralgia on quality-of-lifeRobert W Johnson
NSERM U987, Hopital Ambroise Pare, APHP, F 92100 Boulogne Billancourt, France
BMC Med 8:37. 2010The potentially serious nature of herpes zoster (HZ) and the long-term complication post-herpetic neuralgia (PHN) are often underestimated...
- Similar herpes zoster incidence across Europe: results from a systematic literature reviewSybil Pinchinat
Epidemiology Department, Sanofi Pasteur MSD, 8 Rue Jonas Salk, Lyon, 69007, France
BMC Infect Dis 13:170. 2013b>Herpes zoster (HZ) is caused by reactivation of the varicella-zoster virus (VZV) and mainly affects individuals aged ≥50 years...
- Efficacy, safety, and tolerability of herpes zoster vaccine in persons aged 50-59 yearsKenneth E Schmader
Duke University, North Carolina, USA
Clin Infect Dis 54:922-8. 2012b>Herpes zoster (HZ) adversely affects individuals aged 50-59, but vaccine efficacy has not been assessed in this population...
- Epidemiology of varicella zoster virus infection in Canada and the United KingdomM Brisson
PHLS CDSC, and City University, London
Epidemiol Infect 127:305-14. 2001..Finally, our results provide baseline estimates of varicella and zoster incidence and morbidity for VZV vaccine effectiveness and cost-effectiveness studies...
- Herpes zoster and postherpetic neuralgia surveillance using structured electronic dataMichael Klompas
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
Mayo Clin Proc 86:1146-53. 2011To develop electronic algorithms for rapid, automated surveillance for herpes zoster and postherpetic neuralgia (PHN) using codified electronic health data.
- The incidence and clinical characteristics of herpes zoster among children and adolescents after implementation of varicella vaccinationRachel Civen
Los Angeles County Department of Public Health, Los Angeles, CA 90011, USA
Pediatr Infect Dis J 28:954-9. 2009The varicella-zoster virus (VZV) vaccine strain may reactivate to cause herpes zoster. Limited data suggest that the risk of herpes zoster in vaccinated children could be lower than in children with naturally acquired varicella...
- The impact of herpes zoster and postherpetic neuralgia on health-related quality of life: a prospective studyMelanie Drolet
Unité de recherche en santé des populations, Centre Hospitalier Affilie Universitaire De Quebec, Quebec, Que
CMAJ 182:1731-6. 2010Vaccination against herpes zoster is being considered in many countries. We conducted a multicentre prospective study to describe the impact of herpes zoster and postherpetic neuralgia on health-related quality of life.
- Patient perspective on herpes zoster and its complications: an observational prospective study in patients aged over 50 years in general practiceDidier Bouhassira
Inserm U987, Centre d Evaluation et de Traitement de la Douleur, Hopital Ambroise Pare, Boulogne Billancourt F 92100, France
Pain 153:342-9. 2012Understanding the effect of herpes zoster and zoster-related pain should inform care to improve health-related quality of life in elderly patients...
- Increased risk of stroke after a herpes zoster attack: a population-based follow-up studyJiunn Horng Kang
Department of Physical Medicine and Rehabilitation, The Neuroscience Research Center, Taipei Medical University Hospital, Taipei, Taiwan
Stroke 40:3443-8. 2009..This study aims to investigate the frequency and risk of stroke after a herpes zoster attack using a nationwide, population-based study of a retrospective cohort design...
- Herpes zoster among persons living with HIV in the current antiretroviral therapy eraLeah J Blank
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Acquir Immune Defic Syndr 61:203-7. 2012Previously, herpes zoster (HZ) was found to occur at a higher rate in the HIV population than the general population...
- Incremental 1-year medical resource utilization and costs for patients with herpes zoster from a set of US health plansRonald R White
Department of Global Outcomes Research, Global Human Health, West Point, Pennsylvania, USA
Pharmacoeconomics 27:781-92. 2009Nearly 1 million new episodes of herpes zoster (HZ) occur annually in the US, yet little is known about the medical resource utilization (RU) and costs associated with HZ and its complications.
- Modelling the impact of a combined varicella and zoster vaccination programme on the epidemiology of varicella zoster virus in EnglandAlbert Jan van Hoek
Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, London NW9 5EQ, UK
Vaccine 29:2411-20. 2011This study updates previous work on modelling the incidence of varicella and Herpes Zoster (HZ) following the introduction of childhood vaccination...
- Acute pain in herpes zoster and its impact on health-related quality of lifeJennifer Katz
Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA
Clin Infect Dis 39:342-8. 2004..on physical and emotional functioning have been examined in a number of studies, the impact of acute pain in herpes zoster ("shingles") on health-related quality of life has been neglected...
- Herpes zoster in Germany: quantifying the burden of diseaseBernhard Ultsch
Immunization Unit, Robert Koch Institute, 13086 Berlin, Germany
BMC Infect Dis 11:173. 2011b>Herpes zoster (HZ) is caused by a reactivation of the varicella-zoster-virus (VZV) and mainly affects individuals aged≥50 years...
- Health care utilization and cost burden of herpes zoster in a community populationBarbara P Yawn
Department of Research, Olmsted Medical Center, Rochester, MN 55904, USA
Mayo Clin Proc 84:787-94. 2009To conduct a population-based study to assess health care utilization (HCU) and costs associated with herpes zoster (HZ) and its complications, including postherpetic neuralgia (PHN) and nonpain complications, in adults aged 22 years and ..
- Herpes zoster vaccine in older adults and the risk of subsequent herpes zoster diseaseHung Fu Tseng
Department of Research and Evaluation, Kaiser Permanente, Southern California Medical Group, 100 S Los Robles Ave, Second Floor, Pasadena, CA 91101, USA
JAMA 305:160-6. 2011Approximately 1 million episodes of herpes zoster occur annually in the United States...
- Predictors of postherpetic neuralgia among patients with herpes zoster: a prospective studyMelanie Drolet
URESP, Centre de Recherche FRSQ du CHA Universitaire de Québec, QC, Canada
J Pain 11:1211-21. 2010Postherpetic neuralgia (PHN) is the most common complication of herpes zoster (HZ). The main objectives of this study were to: 1) estimate the severity and duration of PHN; and 2) identify the predictors of PHN...
- Employment related productivity loss associated with herpes zoster and postherpetic neuralgia: a 6-month prospective studyMelanie Drolet
URESP, Centre de Recherche FRSQ du CHA Universitaire de Québec, QC, Canada
Vaccine 30:2047-50. 2012We conducted a prospective multi-center study to assess productivity loss associated with herpes zoster (HZ) and postherpetic neuralgia (PHN)...
- Acute/subacute herpes zoster: healthcare resource utilisation and costs in a group of US health plansRalph P Insinga
Department of Health Economic Statistics, Merck Research Laboratories, North Wales, Pennsylvania 19454 1099, USA
Pharmacoeconomics 25:155-69. 2007Although there are estimated to be nearly 1 million cases of herpes zoster diagnosed in the US each year, the economic costs associated with herpes zoster in the US have not been well described.
- Does monastic life predispose to the risk of Saint Anthony's fire (herpes zoster)?Jacques Gaillat
Department of Infectious and Tropical Diseases, Annecy General Hospital, Pringy, France
Clin Infect Dis 53:405-10. 2011..We therefore compared the frequency of herpes zoster in an adult population with virtually no varicella zoster virus (VZV) exposure with that in the general ..
- Contacts with varicella or with children and protection against herpes zoster in adults: a case-control studySara L Thomas
Infectious Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Lancet 360:678-82. 2002..exposure to varicella-zoster-virus protects individuals with latent varicella-zoster virus infection against herpes zoster by boosting immunity is not known...
- The burden of Herpes Zoster: a prospective population based studyFiona T Scott
Skin Virus Laboratory, Institute for Cell and Molecular Science, 25 29 Ashfield Street, E1 1BB, UK
Vaccine 24:1308-14. 2006..practices in East London, serving 158,716 patients who presented to their general practitioners with acute Herpes Zoster over an 8-month period...
- A prospective study of the herpes zoster severity of illnessMelanie Drolet
Centre Hospitalier Affilie Universitaire De Quebec, Hôpital Saint Sacrement, Quebec, QC, Canada
Clin J Pain 26:656-66. 2010MASTER, a multicenter prospective study, was conducted to provide a thorough understanding of the burden of herpes zoster (HZ) and postherpetic neuralgia (PHN)...
- Epidemiology and cost of herpes zoster and postherpetic neuralgia among patients treated in primary care centres in the Valencian community of SpainAna M Cebrián-Cuenca
Centro de Salud de Ayora, Avenida Argentina, Ayora, Valencia, Spain
BMC Infect Dis 11:302. 2011Data on the epidemiology and costs related to herpes zoster (HZ) and postherpetic neuralgia (PHN) in Spain are scarce; therefore, studies are needed to evaluate the epidemiological and economic impact of HZ and its most common ..
- Epidemiology and economic burden of herpes zoster and post-herpetic neuralgia in Italy: a retrospective, population-based studyLeonardo Emberti Gialloreti
Dipartimento di Sanita Pubblica, Universita di Roma Tor Vergata, Via Montpellier 1, 00133 Roma, Italy
BMC Infect Dis 10:230. 2010Data on the epidemiology and cost of herpes zoster (HZ) and post-herpetic neuralgia (PHN) in Italy are limited...
- Comparing shingles incidence and complication rates from medical record review and administrative database estimates: how close are they?Barbara P Yawn
Research Department, Olmsted Medical Center, 210 Ninth Street SE, Rochester, MN 55904, USA
Am J Epidemiol 174:1054-61. 2011Accurate rates of herpes zoster incidence and complication have become of greater interest as studies have suggested an increasing temporal trend in incidence rates across all age groups and long-term follow-up studies of vaccine ..
- The incidence of, risk factors for, and sequelae of herpes zoster among HIV patients in the highly active antiretroviral therapy eraKelly A Gebo
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Acquir Immune Defic Syndr 40:169-74. 2005Whereas the incidence, risk factors, and clinical sequelae of herpes zoster have been studied in the general population and in HIV patients in the era before highly active antiretroviral therapy (HAART), they have yet to be fully ..
- Increasing incidence of herpes zoster among VeteransDavid Rimland
Atlanta Veterans Affairs Medical Center, Decatur, Atlanta, Georgia, USA
Clin Infect Dis 50:1000-5. 2010The incidence of herpes zoster in the United States has been estimated to be > or =1 million cases annually, with a higher rate in adults older than 60 years...
- Risk of herpes zoster in CKD: a matched-cohort study based on administrative dataMei Yi Wu
Department of Nephrology, Shuang Ho Hospital, Taipei Medical University, Taiwan
Am J Kidney Dis 60:548-52. 2012..Although decreased cellular immunity increases susceptibility to herpes zoster, the risk of herpes zoster in patients with earlier stages of chronic kidney disease (CKD) is unclear.
- The impact of acute herpes zoster pain and discomfort on functional status and quality of life in older adultsKenneth E Schmader
Duke University, Durham, NC, USA
Clin J Pain 23:490-6. 2007To describe the interference of herpes zoster (HZ) pain and discomfort with activities of daily living (ADLs) and health-related quality of life (HRQL) during the acute rash phase, and to quantify the relationship between acute HZ pain ..
- The epidemiological, clinical, and pathological rationale for the herpes zoster vaccineKenneth Schmader
Center for the Study of Aging and Human Development and Division of Geriatrics, Department of Medicine, Duke University Medical Center, North Carolina, USA
J Infect Dis 197:S207-15. 2008Worldwide, herpes zoster (HZ) affects millions of patients (particularly older adults) annually and causes significant suffering due to acute and chronic pain, or postherpetic neuralgia (PHN)...
- Cost-effectiveness of a vaccine to prevent herpes zoster and postherpetic neuralgia in older adultsMichael B Rothberg
Division of General Medicine and Geriatrics, Department of Medicine, Baystate Medical Center, Springfield, MA 01199, USA
Clin Infect Dis 44:1280-8. 2007A vaccine to prevent herpes zoster was recently approved by the United States Food and Drug Administration. We sought to determine the cost-effectiveness of this vaccine for different age groups.
- Clinical practice. Herpes zosterJohn W Gnann
Departments of Medicine, University of Alabama at Birmingham, Birmingham, Ala 35294 2170, USA
N Engl J Med 347:340-6. 2002
- Development of a measure of the burden of pain due to herpes zoster and postherpetic neuralgia for prevention trials: adaptation of the brief pain inventoryPaul M Coplan
Merck Research Laboratories, West Point, Pennsylvania 19486, USA
J Pain 5:344-56. 2004In preparation for clinical trials of a vaccine against herpes zoster (HZ), we conducted a prospective, observational study to evaluate (1) the Zoster Brief Pain Inventory (ZBPI), an HZ-specific questionnaire to quantify HZ pain and ..
- The incidence of shingles and its implications for vaccination policyRachel S Chapman
Birmingham Research Unit of the Royal College of General Practitioners, Lordswood House, 54 Lordswood Road, Harborne, Birmingham B17 9DB, UK
Vaccine 21:2541-7. 2003....
- Herpes zoster: Burden of disease in FranceS Gonzalez Chiappe
INSERM, U707, F 75012 Paris, France
Vaccine 28:7933-8. 2010..b>Herpes zoster data was obtained from the Sentinelles surveillance general practitioners (GPs) network, the PMSI Data ..
- Herpes zoster risk factors in a national cohort of veterans with rheumatoid arthritisJay R McDonald
St Louis Veterans Affairs Medical Center, St Louis, Missouri 63106, USA
Clin Infect Dis 48:1364-71. 2009b>Herpes zoster occurs more commonly in patients taking immunosuppressive medications, although the risk associated with different medications is poorly understood.
- Risk of herpes zoster in patients with rheumatoid arthritis treated with anti-TNF-alpha agentsAnja Strangfeld
Epidemiology Unit, German Rheumatism Research Center, Chariteplatz 1, 10117 Berlin, Germany
JAMA 301:737-44. 2009..The risk of bacterial infection is increased in patients treated with drugs that inhibit tumor necrosis factor alpha (TNF-alpha). Little is known about the reactivation of latent viral infections during treatment with TNF-alpha inhibitors...
- Epidemiology of herpes zoster and its relationship to varicella in Japan: A 10-year survey of 48,388 herpes zoster cases in Miyazaki prefectureNozomu Toyama
Toyama Dermatologic Clinic, Nichinan City, Miyazaki, Japan
J Med Virol 81:2053-8. 2009From 1997 to 2006, a total of 48,388 patients with herpes zoster, ranging from a 3-month-old girl to a 102-year-old woman, were monitored at the 46 dermatology clinics in the Miyazaki Prefecture, which has a population of about 1...
- Herpes zoster vaccine effectiveness against incident herpes zoster and post-herpetic neuralgia in an older US population: a cohort studySinead M Langan
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS Med 10:e1001420. 2013b>Herpes zoster is common and has serious consequences, notably post-herpetic neuralgia (PHN)...
- Herpes zoster in Australia: evidence of increase in incidence in adults attributable to varicella immunization?A Jardine
Public Health Unit, Sydney South West Area Health Service, Camperdown, New South Wales
Epidemiol Infect 139:658-65. 2011Rates of herpes zoster (HZ) hospitalizations, antiviral prescriptions, and New South Wales emergency-department presentations for age groups <20, 20-39, 40-59 and ⩾60 years were investigated...
- Herpes zoster burden of illness and health care resource utilisation in the Australian population aged 50 years and olderAlicia N Stein
CSL Limited, 45 Poplar Road, Parkville, Victoria 3052, Australia
Vaccine 27:520-9. 2009..4 general practitioner consultations. Total costs to the health care system were estimated as approximately 32.8 million per year. The substantial burden of zoster and PHN highlights the potential benefit of zoster vaccination...
- Gender difference in the incidence of shinglesD M Fleming
Birmingham Research Unit of the Royal College of General Practitioners, 54 Lordswood Road, Harborne, Birmingham B17 9DB, UK
Epidemiol Infect 132:1-5. 2004..Gender-specific age-standardized incidence rates of shingles were calculated for each year and showed a consistent female excess in each of the 8 years (average annual excess 28%)...
- Predicting and preventing post-herpetic neuralgia: are current risk factors useful in clinical practice?Pietro G Coen
Queen Mary s School of Medicine and Dentistry, University of London, Department of Medical Microbiology, 25 29 Ashfield Street, London E1 1BB, UK
Eur J Pain 10:695-700. 2006Post-herpetic neuralgia (PHN) following acute herpes zoster remains a significant cause of neuropathic pain especially in the elderly...
- European seroepidemiology network 2: Standardisation of assays for seroepidemiology of varicella zoster virusFernando de Ory
Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
J Clin Virol 36:111-8. 2006..The aim of the European Sero-Epidemiology Network (ESEN2) is to harmonise the serological surveillance of vaccine-preventable diseases in Europe...
- Epidemiological features and costs of herpes zoster in Taiwan: a national study 2000 to 2006Jaw Shyang Jih
Department of Dermatology, National Yang Ming University, Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan
Acta Derm Venereol 89:612-6. 2009To analyse the epidemiological characteristics and related costs of herpes zoster in Taiwan, a nationally representative cohort of 1,000,000 individuals from the National Health Insurance register was followed up from 2000 to 2006 and ..
- Herpes zoster recurrences more frequent than previously reportedBarbara P Yawn
Department of Research, Olmsted Medical Center, 210 9th Street SE, Rochester, MN 55904, USA
Mayo Clin Proc 86:88-93. 2011To present population-based estimates of herpes zoster (HZ) recurrence rates among adults.
- Diabetes as a risk factor for herpes zoster infection: results of a population-based study in IsraelA D Heymann
Medical Division, Maccabi Healthcare Services, 27 HaMered St, Tel Aviv, 68125, Israel
Infection 36:226-30. 2008..by impaired cell-mediated immunity, which potentially may increase the risk for infectious diseases, including herpes zoster (HZ). However, data on the relation between DM and HZ are scarce...
- Recommendations for the management of herpes zosterRobert H Dworkin
Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA
Clin Infect Dis 44:S1-26. 2007The objective of this article is to provide evidence-based recommendations for the management of patients with herpes zoster (HZ) that take into account clinical efficacy, adverse effects, impact on quality of life, and costs of ..
- Risk of Herpes zoster in patients with underlying diseases: a retrospective hospital-based cohort studyA Hata
Department of Infectious Diseases, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, 2 4 20, Ohgimachi, Kita ku, Osaka 530 8480, Japan
Infection 39:537-44. 2011To determine the incidence of Herpes zoster in patients with one of 17 specific underlying diseases compared with that in patients with other underlying diseases.
- The incidence of varicella and herpes zoster in Taiwan during a period of increasing varicella vaccine coverage, 2000-2008D Y Chao
Graduate Institute of Microbiology and Public Health, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan
Epidemiol Infect 140:1131-40. 2012..However the vaccine's long-term impact on the incidence of herpes zoster (HZ) has attracted attention...
- The health and economic burden of chickenpox and herpes zoster in BelgiumJ Bilcke
Center for Health Economic Research and Modeling Infectious Diseases, Vaccine and Infectious Disease Institute VAXINFECTIO, University of Antwerp, Universiteitsplein 1, Wilrijk, Belgium
Epidemiol Infect 140:2096-109. 2012Varicella-zoster virus causes chickenpox (CP) and after reactivation herpes zoster (HZ). Vaccines are available against both diseases warranting an assessment of the pre-vaccination burden of disease...
- The cost-effectiveness of varicella and combined varicella and herpes zoster vaccination programmes in the United KingdomAlbert Jan van Hoek
Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, LondonNW9 5EQ, UK
Vaccine 30:1225-34. 2012..countries have not introduced it into their national schedules, partly because of concerns about whether herpes zoster (HZ, shingles) will increase due to a lack of exogenous boosting...
- Risk of herpes zoster in patients treated with long-term hemodialysis: a matched cohort studyChien Chun Kuo
Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Taiwan
Am J Kidney Dis 59:428-33. 2012The risk of herpes zoster in the dialysis population relative to the general population is not known...
- Exposure to varicella boosts immunity to herpes-zoster: implications for mass vaccination against chickenpoxM Brisson
Immunisation Division, PHLS Communicable Disease Surveillance Centre, London, UK
Vaccine 20:2500-7. 2002..Mass varicella vaccination is expected to cause a major epidemic of herpes-zoster, affecting more than 50% of those aged 10-44 years at the introduction of vaccination...
- Risk of herpes zoster among patients with chronic obstructive pulmonary disease: a population-based studyYa Wen Yang
Department of Dermatology, School of Medicine, College of Medicine, Taipei Medical University, Taiwan
CMAJ 183:E275-80. 2011..in chronic obstructive pulmonary disease (COPD) is hypothesized to predispose patients to development of herpes zoster. However, the risk of herpes zoster among patients with COPD is undocumented...
- Contacts with children and young people and adult risk of suffering herpes zosterM Salleras
Dermatology Department, Sagrado Corazón Hospital, Barcelona, Spain
Vaccine 29:7602-5. 2011..Cases of herpes zoster in immunocompetent healthy patients aged ≥ 25 years seen in the dermatology department of the Sagrado Corazó..
- Postherpetic neuralgia: epidemiology, pathophysiology and managementRobert W Johnson
Bristol Royal Infirmary, University of Bristol, Bristol, UK
Expert Rev Neurother 7:1581-95. 2007Postherpetic neuralgia (PHN) is a neuropathic pain syndrome and is the most common complication of herpes zoster (HZ; shingles)...
- VZV T cell-mediated immunityAdriana Weinberg
University of Colorado Denver, Aurora, CO 80045, USA
Curr Top Microbiol Immunol 342:341-57. 2010..these responses decline, as occurs with aging or iatrogenic immune suppression, reactivation of VZV leads to herpes zoster. Similarly, the magnitude of these responses early after the onset of herpes zoster correlates with the extent ..
- Systemic absorption of topical lidocaine in normal volunteers, patients with post-herpetic neuralgia, and patients with acute herpes zosterBryan J Campbell
Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Pharm Sci 91:1343-50. 2002..and gel formulations in normal volunteers, patients with post-herpetic neuralgia, and patients with acute herpes zoster. The bioavailability of lidocaine from the patch formulation averaged 3%, and was similar after single and ..
- Herpes zoster and postherpetic neuralgia: incidence and risk indicators using a general practice research databaseWim Opstelten
Julius Center for General Practice and Patient Oriented Research, University Medical Center Utrecht, PO Box 85060, 3500 AB Utrecht, The Netherlands
Fam Pract 19:471-5. 2002Postherpetic neuralgia (PHN) is a frequent complication of herpes zoster (HZ). Treatment results of this severe and long-lasting pain syndrome are often disappointing...
- Insulin degrading enzyme is a cellular receptor mediating varicella-zoster virus infection and cell-to-cell spreadQingxue Li
Laboratory of Clinical Infectious Diseases, Medical Virology Section, National Institutes of Health, Bethesda, MD, 20892 USA
Cell 127:305-16. 2006..These studies indicate that IDE is a cellular receptor for both cell-free and cell-associated VZV...
- Varicella-zoster virus transfer to skin by T Cells and modulation of viral replication by epidermal cell interferon-alphaChia Chi Ku
Department of Pediatrics, Stanford University, School of Medicine, Stanford, CA 94305, USA
J Exp Med 200:917-25. 2004..Modulation of VZV replication by cutaneous innate immunity may avoid an incapacitating infection of the host that would limit opportunities for VZV transmission...
- Herpes zoster and postherpetic neuralgia: prevention and managementJulia Fashner
Saint Joseph Family Medicine Residency Program, South Bend, IN 46617, USA
Am Fam Physician 83:1432-7. 2011b>Herpes zoster (shingles) is diagnosed clinically by recognition of the distinctive, painful vesicular rash appearing in a unilateral, dermatomal distribution...
- A study of shingles and the development of postherpetic neuralgia in East LondonFiona T Scott
Department of Medical Microbiology, Medical and Dental School, Queen Mary College, 25 29 Ashfield Street, London E1 1BB, England, UK
J Med Virol 70:S24-30. 2003..More accurate prediction of which subset of elderly patients are most at risk of PHN may enable targeted prescribing of the most potent drugs to those most likely to benefit...
- Assessment of transcriptomal analysis of Varicella-Zoster-virus gene expression in patients with and without post-herpetic neuralgiaG H Ashrafi
Department of Neurology, Division of Clinical Neurosciences, Institute of Neurological Sciences, Southern General Hospital, Glasgow, Scotland, UK
Virus Genes 41:192-201. 2010..a human herpes virus that reactivates from a latent state in human trigeminal and dorsal root ganglia to cause herpes zoster (shingles) which is a painful vesicular dermatomal skin eruption...
- Cutaneous metastatic rectal carcinoma masquerading as herpes zosterJessica Eichinger
San Antonio Military Medical Center South, San Antonio, TX 78236, USA
South Med J 104:233-5. 2011..Physicians providing care to patients with a history of cancer should maintain a high clinical suspicion for cutaneous metastases in patients with new or evolving skin conditions...
- [Herpes zoster: incidence study among "sentinel" general practitioners]S Czernichow
, , Paris, France
Ann Dermatol Venereol 128:497-501. 2001INTRODUCTION: Herpes zoster is a frequent disease but its incidence in France is unknown. METHODS: We conducted a postal survey among the general practitioners of the "Sentinel" network...
- Extensive cutaneous larva migrans with folliculitis mimicking multimetameric herpes zoster presentation in an adult traveler returning from ThailandDenis Malvy
Travel Clinics and Tropical Disease Unit, Department of Internal Medicine, Infectious Diseases and Tropical Medicine, University Hospital Center, Bordeaux, France
J Travel Med 13:244-7. 2006..Simple anamnestic information--often revealing beach activities--and clinical aspect of the creeping eruption allow to prevent diagnosis delay and to avoid aggressive or inadequate intervention...
- Willingness to pay for a QALY based on community member and patient preferences for temporary health states associated with herpes zosterTracy A Lieu
Department of Ambulatory Care and Prevention, Harvard Pilgrim Health Care and Harvard Medical School, Boston, Massachusetts 02215, USA
Pharmacoeconomics 27:1005-16. 2009..had the opportunity to evaluate WTP per QALY using data from a survey on temporary health outcomes related to herpes zoster. Our aims were to (i) describe how much community members are willing to pay to save a QALY based on scenarios ..
- Herpes zoster in HIV-1-infected patients in the era of highly active antiretroviral therapy: a prospective observational studyChien Ching Hung
Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, 7 Chung Shan South Road, Taipei, Taiwan
Int J STD AIDS 16:673-6. 2005..differentiation CD4+ count of 61 x 10(6) cells/L (range, 1-1206 x 10(6) cells/L) developed 103 episodes of herpes zoster [HZ], with an incidence of 5.67 per 100 person-years (PY)...
- Seroprevalence of varicella-zoster virus in KoreaWon Suk Choi
Division of Infectious Disease, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
J Med Virol 82:2123-6. 2010Varicella-zoster virus (VZV) causes chickenpox and herpes zoster. Korea is assumed to have a high seroprevalence of VZV, although data are scant...
- Wet cupping therapy for treatment of herpes zoster: a systematic review of randomized controlled trialsHuijuan Cao
Beijing University of Chinese Medicine
Altern Ther Health Med 16:48-54. 2010Wet cupping is a traditional Chinese medicine therapy commonly used in treating herpes zoster in China, and clinical studies have shown that wet cupping may have beneficial effect on herpes zoster compared with Western medication.
- Productive varicella-zoster virus infection of cultured intact human gangliaKavitha Gowrishankar
Center for Virus Research, Westmead Millenium Institute, and Department of Infectious Diseases and Immunology, University of Sydney, Blackburn Building, 2006 NSW, Australia
J Virol 81:6752-6. 2007..This model enables VZV infection of ganglionic cells to be studied in the context of intact DRG...
- Burden of herpes zoster requiring hospitalization in Spain during a seven-year period (1998-2004)Angel Gil
Department of Health Sciences, Rey Juan Carlos University, Avda de Atenas s n, 28922 Alcorcon, Madrid, Spain
BMC Infect Dis 9:55. 2009..A population-based retrospective epidemiological study to estimate the burden of herpes zoster requiring hospitalization in Spain was conducted.
- The comparative sero-epidemiology of varicella zoster virus in 11 countries in the European regionA Nardone
Health Protection Agency, Centre for Infections, London, UK
Vaccine 25:7866-72. 2007..There are substantial differences in VZV sero-epidemiology within the European region, which will need to be taken into account in designing national policies regarding VZV vaccination...
- Predictors of pain intensity and persistence in a prospective Italian cohort of patients with herpes zoster: relevance of smoking, trauma and antiviral therapyGiustino Parruti
Infectious Disease Unit, Pescara General Hospital, Pescara, Italy
BMC Med 8:58. 2010b>Herpes zoster (HZ) is a common disease, characterized by rash-associated localized pain. Its main complication, post-herpetic neuralgia (PHN), is difficult to treat and may last for months to years in the wake of rash resolution...
- Varicella-zoster virusA M Arvin
Department of Pediatrics, Stanford University School of Medicine, California 94305 5119, USA
Clin Microbiol Rev 9:361-81. 1996Varicella-zoster virus (VZV) is a ubiquitous human alphaherpesvirus that causes varicella (chicken pox) and herpes zoster (shingles)...
- Varicella-zoster virus-specific immune responses to herpes zoster in elderly participants in a trial of a clinically effective zoster vaccineAdriana Weinberg
University of Colorado Denver, Denver, CO, USA
J Infect Dis 200:1068-77. 2009..were to evaluate the association between varicella-zoster virus (VZV)-specific humoral and cell-mediated immunity (CMI) to herpes zoster (HZ) and protection against HZ morbidity and to compare immune responses to HZ and zoster vaccine.
- The role of sympathetic nerve blocks in herpes zoster and postherpetic neuralgiaC L Wu
The Johns Hopkins Hospital, Department of Anesthesiology and Critical Care Medicine, Division of Pain Medicine, 550 N Broadway, Suite 301, Baltimore, MD 21205, USA
Pain 87:121-9. 2000The most common complication of herpes zoster in immunocompetent patients is postherpetic neuralgia (PHN)...
- Herpes simplex virus-1 and varicella-zoster virus latency in gangliaBradley M Mitchell
Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA
J Neurovirol 9:194-204. 2003..For each virus, remaining questions and future studies to understand the mechanism of latency are discussed with respect to prevention of serious cutaneous, ocular, and neurologic disease produced by virus reactivation...
- Advances in the understanding of the pathogenesis and epidemiology of herpes zosterAnne A Gershon
Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
J Clin Virol 48:S2-7. 2010..root ganglia during varicella and, when reactivated, travels along the sensory nerve axons to cause shingles (herpes zoster [HZ])...
- Herpes zoster pathogenesis and cell-mediated immunity and immunosenescenceMichael N Oxman
University of California, San Diego, Staff Physician Infectious Diseases, VA San Diego Healthcare System, San Diego, CA 92161 0001, USA
J Am Osteopath Assoc 109:S13-7. 2009b>Herpes zoster, or shingles, is a localized disease characterized by unilateral radicular pain and a vesicular rash limited to the area of skin innervated by a single dorsal root or cranial sensory ganglion...
- Herpes zoster and postherpetic neuralgia: optimizing management in the elderly patientRobert W Johnson
Bristol Royal Infirmary and University of Bristol, Bristol, United Kingdom
Drugs Aging 25:991-1006. 2008b>Herpes zoster (HZ) results from reactivation of varicella-zoster virus (VZV) that has been persistent and clinically dormant in spinal ganglia or cranial sensory nerves since primary infection with VZV...
- Prevalence of postherpetic neuralgia after a first episode of herpes zoster: prospective study with long term follow upS Helgason
Arbaer Health Care Centre, IS 110 Reykjavik, Iceland S Helgason
BMJ 321:794-6. 2000To estimate the frequency, duration, and clinical importance of postherpetic neuralgia after a single episode of herpes zoster.
- The epidemiology of varicella and herpes zoster in The Netherlands: implications for varicella zoster virus vaccinationHester de Melker
Centre for Infectious Disease Epidemiology, National Institute of Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
Vaccine 24:3946-52. 2006We studied the epidemiology of varicella (chickenpox) and herpes zoster (shingles) in The Netherlands to assess the desirability to implement routine varicella zoster virus vaccination in The Netherlands...
- Increased risk of Guillain-Barré Syndrome following recent herpes zoster: a population-based study across TaiwanJiunn Horng Kang
Departments of 1Physical Medicine and Rehabilitation and 2Neurology, 3Neuroscience Research Center, and 4School of Health Care Administration, Taipei Medical University, Taipei, Taiwan
Clin Infect Dis 51:525-30. 2010Guillain-Barré syndrome (GBS) has been sporadically reported to be associated with herpes zoster reactivation. However, the risk for developing GBS after herpes zoster reactivation remains unknown...
- Varicella zoster virus: review of its managementM B Mustafa
Oral Medicine Section, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Khartoum, Khartoum, Sudan
J Oral Pathol Med 38:673-88. 2009..The first choice of any of these medications should be guided by the patient's medical health, the likely adverse effects of the drug and the patient's preference...
- Herpes zosterDavid W Wareham
Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry
BMJ 334:1211-5. 2007
- Herpes zoster vaccination among adults aged 60 years or older in the United States, 2007: uptake of the first new vaccine to target seniorsPeng Jun Lu
National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Vaccine 27:882-7. 2009Approximately one million new cases of shingles (herpes zoster [HZ]), a severely painful and debilitating disease caused by reactivation of varicella-zoster virus (VZV), occur in the United States each year...
- Spinal cord stimulation in postherpetic neuralgia and in acute herpes zoster painHenning Harke
Department of Anesthesia and Pain Therapy, Klinikum Krefeld, Krefeld, Germany
Anesth Analg 94:694-700; table of contents. 2002..In addition, four patients with acute herpes zoster (HZ) pain were studied simultaneously...
- Herpes zoster guidelines of the German Dermatological SocietyG Gross
J Clin Virol 27:308-9. 2003
- Herpes Zoster mimicking recurrence of lymphoma on PET/CTJudith M Joyce
Division of Nuclear Medicine, Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Clin Nucl Med 31:104-5. 2006
- Cutaneous multifocal melanoma metastases clinically resembling herpes zosterK Kondras
J Eur Acad Dermatol Venereol 20:470-2. 2006
- Herpes zoster vaccination among adults aged 60 years and older, in the U.S., 2008Peng Jun Lu
National Center for Immunization and Respiratory Diseases, CDC, Atlanta, GA, USA
Am J Prev Med 40:e1-6. 2011Shingles (herpes zoster [HZ]) is a localized, generally painful and debilitating disease that occurs most frequently among older adults. It is caused by reactivation of varicella-zoster virus...
- Successful IL-2 therapy for relapsing herpes zoster infection in a patient with idiopathic CD4+ T lymphocytopeniaK Warnatz
Department of Internal Medicine, University Hospital Freiburg, Germany
Immunobiology 202:204-11. 2000..Here we describe a 65-year old patient with relapsing generalized herpes zoster infection due to ICL and a severe panlymphocytopenia...
- VZV BACs: New Tools for Pathogenesis ResearchNikolaus Osterrieder; Fiscal Year: 2005Varicella zoster virus (VZV) causes chickenpox (varicella) and shingles (herpes zoster)...
- Cdk inhibitors: novel antivirals for VZVJennifer Moffat; Fiscal Year: 2007unreadable] DESCRIPTION (provided by applicant): Immunocompromised individuals are at high risk for herpes zoster caused by reactivation of varicella zoster virus (VZV)...
- Tomotherapy and Hematopoietic Stem Cells For Tolerance to Kidney TransplantsSamuel Strober; Fiscal Year: 2013..antibody responses to influenza virus vaccination after transplantation, as well as recall T cell responses to herpes zoster, herpes simplex, cytomegalovirus antigens, and tetanus toxoid...
- Varicella zoster virus-Induced Pain in a Rat Model of Post-Herpetic NeuralgiaPaul R Kinchington; Fiscal Year: 2013Post-Herpetic Neuralgia (PHN) is a common and exceedingly painful complication of herpes zoster that is debilitating, intractable, long-lasting and difficult to treat...
- Vitamin D and Immunosenescence in Older Long-Term Care ResidentsAdit A Ginde; Fiscal Year: 2013..and Pediatrics at UCD, whose research has focused on characterizing and improving response to influenza and herpes zoster vaccines...
- The molecular pathogenesis of varicella zoster virus infectionDonald Gilden; Fiscal Year: 2013..With aging, a declining cell-mediated immunity to VZV leads to virus reactivation, manifesting as herpes zoster (shingles) characterized by pain and rash restricted to 1-3 dermatomes...
- Vaccination and infection: indicators of immunological health and responsivenessMARK MORRIS DAVIS; Fiscal Year: 2013..across a range of different vaccines including influenza, both seasonal and the new pandemic H1N1v, Herpes zoster, Measles, and the bacterium Neisseria meningitidis...
- A new in vitro neuron model of axonal transport and persistence of varicella zostPaul R Kinchington; Fiscal Year: 2013..site of a decades-long state of persistence, from which VZV can reactivate to cause the debilitating disease Herpes zoster. VZV remains a major source of human morbidity, even in an age of commercial vaccines, as most adults harbor ..
- Civamide Nasal Spray for the Treatment of Postherpetic Neuralgia of the TrigeminaScott B Phillips; Fiscal Year: 2013..25,26 PHN of the [TN] is a chronic condition characterized by extreme pain following herpes zoster infection, (commonly called shingles,) in the areas of the face and scalp which are innervated by the [TN]...
- Zoster Vaccine and Risk Factors of Zoster and Post-Herpetic NeuralgiaHUNGFU TSENG; Fiscal Year: 2013DESCRIPTION (provided by applicant): Herpes zoster (HZ), or shingles, is a painful vesicular rash, usually unilateral, caused by the varicella zoster virus (VZV)...
- Impact of immune senescence on herpes zoster in a nonhuman primate modelIlhem Messaoudi; Fiscal Year: 2013DESCRIPTION (provided by applicant): Reactivation of latent varicella zoster virus (VZV) leads to herpes zoster (HZ, also known as shingles), a disease that causes major morbidity and occasionally mortality in older individuals...
- Risk of Herpes Zoster Among Adults with AsthmaYoung J Juhn; Fiscal Year: 2013DESCRIPTION (provided by applicant): Herpes zoster (HZ) or shingles is a serious health problem occurring in one of three adults during their life time, nearly one million cases a year in the United States...
- ANTIGENIC DETERMINANTS OF VARICELLA VIRUSCharles Grose; Fiscal Year: 2006unreadable] DESCRIPTION (provided by applicant): Varicella-zoster virus (VZV) is the cause of chickenpox and herpes zoster. VZV infection is a recurrent problem in both transplant and cancer patients...
- Varicella Active Surveillance ProjectLaurene Mascola; Fiscal Year: 2010..We propose to continue varicella and herpes zoster (HZ) active surveillance and extend the project to the city of Santa Clarita to increase the population to ..
- DEFINITION OF THE CHRONIC EPSTEIN-BARR VIRUS SYNDROMEJames Jones; Fiscal Year: 1990..Symptom scores, family history records, antibody titers to EBV antigens, adenovirus, herpes zoster, influenza A, herpes simplex, cytomegalovirus, Mycoplasma pneumoniae and EBV virus excretion will be measured...
- PATHOPHYSIOLOGY OF VARICELLA ZOSTER VIRUS INFECTIONMartin Myers; Fiscal Year: 1980..Clinical and pathologic studies of patients with herpes zoster have implicated the sensory neuroganglia as a probable site of persistent viral infection...
- SYNTHETIC MASKED NUCLEOSIDES FOR ANTICANCER STUDIESKyoichi Watanabe; Fiscal Year: 1992..FIAC, underwent Phase I and II clinical trials and proved to be superior to ara-A for the treatment of Herpes zoster infections in immunosuppressed cancer patients, and (c) another nucleoside, FMAU, exhibited even more potent ..
- Novel Topical Treatment for Postherpetic NeuralgiaCharles Gauntt; Fiscal Year: 2005..PHN is defined as pain in the affected dermatome that persists or appears after the rash of herpes zoster (HZ) has healed...
- Analgesia in Herpes Zoster and Postherpetic NeuralgiaRobert Dworkin; Fiscal Year: 2001b>Herpes zoster is a common and painful neurological disease that is caused by reactivation of the varicella-zoster virus...
- PAIN & NEURAL DYSFUNCTION FROM ACUTE HERPES ZOSTERKarin Petersen; Fiscal Year: 2003Pain, nerve trunk inflammation, and neuronal injury are hallmarks of acute herpes zoster (AHZ or 'shingles')...
- Zeiss LSM 510-NLO multiphoton laser scanning microscopeJoseph Mazurkiewicz; Fiscal Year: 2003..cutaneous innervation in normal and pathologic skin to study pain and neural dysfunction resulting from Herpes Zoster using mutiply-fluorescent-labeled thick samples of human skin. Dr...
- OCULAR & OTHER VARICELLA/ZOSTER DISEASE IN MODELSEDMUND DUNKEL; Fiscal Year: 1993..Varicella is the most common infectious disease in the USA. Reactivated "latent" VZV infection, herpes zoster, is a widespread, often debilitating disease especially in the elderly or immunocompromised patient...
- TAI CHI CHIH AND VARICELLA ZOSTER IMMUNITYMichael Irwin; Fiscal Year: 2001Both the incidence and severity of herpes zoster (HZ) or shingles increase markedly with increasing age due to a decline in varicella zoster virus (VZV) specific immunity...
- SYMPATHETIC EFFERENT MODULATION OF PAINWilliam Roberts; Fiscal Year: 1993..the physiology of sympathetically dependent pain, such as that in reflex sympathetic dystrophy, acute herpes zoster and some cases of low back pain...
- HERPES ZOSTER: THERAPY AND PROPHYLAXIS IN HIV INFECTIONKathleen Brady; Fiscal Year: 2004..The research component will focus on herpes zoster in the HIV-infected host...
- VZV Receptors and Infective MechanismsAnne Gershon; Fiscal Year: 2007..It may also make it possible to develop a safer and more efficacious vaccine. ..
- PEDIATRICS AIDS CLINICAL TRIALS GROUPAnne Gershon; Fiscal Year: 2006..We have competent, outstanding staff whose aim is not only to provide compassionate medical care to HIV-infected patients but also to perform meaningful and useful research on prevention and treatment of HIV infection. ..
- Herpes Zoster and Medications in the ElderlyKenneth Schmader; Fiscal Year: 2005..VA Medical Centers with a strong commitment, funding and publication record in patient-oriented research in herpes zoster and medications in the elderly and a history of mentoring house staff and junior faculty in clinical research...
- ONTOGENY OF MEASLES IMMUNITY IN INFANTSAnn Arvin; Fiscal Year: 2006..Understanding the maturation of host responses to viral antigens during the first year of life has general relevance for vaccine strategies in infancy. ..
- Neurite density in skin as a marker for neuropathic painAnne Louise Oaklander; Fiscal Year: 2005..in adults with one of two common neuropathic pain conditions, postherpetic neuralgia (PHN) after shingles (herpes zoster), or painful neuropathy in the lower legs from diabetes mellitus, and in rat models of these conditions...
- Varicella and Herpes Zoster after Varicella VaccinationSHEILA WIENMANN; Fiscal Year: 2008..In addition, herpes zoster after vaccination is not uncommon, and vaccine-type varicella virus has been isolated from some cases...
- Sleep and Immune Mechanisms in Rheumatoid ArthritisMichael Irwin; Fiscal Year: 2009..Results from this study will guide the development of interventions that target disordered sleep with potential effects on disability in RA. ..
- Gene Expression in Acute and Chronic Neurologic DiseaseDonald Gilden; Fiscal Year: 2008..This concerted effort is focused on prospective studies to delineate the cause, pathogenesis and eventual prevention of viral and demyelinating diseases of the human nervous system. ..
- Tai Chi Effects on Chronic Insomnia in Breast Cancer Survivors: Immune MechanismsMichael R Irwin; Fiscal Year: 2010..This project will constitute the first, randomized controlled clinical trial of the effects of TCC on sleep outcomes in breast cancer survivors, and will advance psychobiological models of insomnia treatment mechanisms. ..
- BEHAVIORAL INTERVENTION FOR HERPES ZOSTER RISK IN AGINGMichael Irwin; Fiscal Year: 2003Description (adapted from investigator's abstract): The incidence and severity of herpes zoster (HZ) or shingles increase markedly with increasing age due to a decline in varicella zoster virus (VZV) specific immunity...
- DEPRESSION AND TRIAL OF VARICELLA VACCINE IN THE ELDERLYMichael Irwin; Fiscal Year: 2003..much evidence indicates that cell mediated immunity plays a critical role in limiting the occurrence of herpes zoster (HZ) and its complications, the effect of major depression on VZV-specific cellular immunity will be examined...
- RESEARCH PERSPECTIVES IN PNI, TRAINEE TRAVELMichael Irwin; Fiscal Year: 2006..abstract_text> ..
- Cocaine Dependence: EEG Sleep and CytokinesMichael Irwin; Fiscal Year: 2005..abstract_text> ..
- Alcoholism: Sleep and Cytokines in African AmericansMichael Irwin; Fiscal Year: 2005..g., cytokine antagonists) for sleep disturbance in alcoholism. ..
- Mechanisms of chemotherapy-evoked neuropathic painGary Bennett; Fiscal Year: 2009....
- NEUROPATHIC PAIN FROM AN EXPERIMENTAL NEURITISGary Bennett; Fiscal Year: 2002..Electrophysiological recordings from identified sensory axons will determine if abnormal discharge arises at the site of inflammation and if there is peripheral sensitization due to an antidromically-conducted ectopic discharge. ..
- Respiratory Viruses and Airflow Obstruction after HCTMichael Boeckh; Fiscal Year: 2008..These studies will improve our understanding of the interaction between respiratory viruses and late pulmonary complications after HCT, which will ultimately enable us to formulate more rational treatment strategies. ..
- Genetic Resistance to Oncogenic Human PapillomavirusesStephen Tyring; Fiscal Year: 2004..Thus, this study is an important step in the development of an HPV vaccine to prevent infection. ..
- Functional Senescence of Innate Immunity and PneumoniaKevin High; Fiscal Year: 2003..These data are essential to design meaningful studies using the case-control method, the most effective means of studying the link between immune senescence and infection risk. ..
- DIETARY FATTY CONTROL OF INFLAMMATIONKevin High; Fiscal Year: 2002..Health relateness: Answering these fundamental questions will shed critical light on the feasibility of utilizing dietary fatty acids to regulate AA metabolism and related clinical disorders. ..
- Brucella, Aging and Role of IL-17 in Host DefenseKevin High; Fiscal Year: 2005..The data generated in this proposal will form the foundation of future R01 proposals aimed at enhancing immunity vs. intracellular pathogens in our aging population. ..
- Animal models to design & evaluate improved VZV vaccinesWAYNE GRAY; Fiscal Year: 2007..The virus may reactivate later in life to cause herpes zoster (shingles) and postherpetic neuralgia...
- Mammographic Density in a Multi-Ethnic CohortLaurel Habel; Fiscal Year: 2005..abstract_text> ..
- INTEGRATE/PHARMACOKINETIC/ANTIRETROVIRUS RESISTANCE TESTEdward Acosta; Fiscal Year: 2006..abstract_text> ..
- Pathogen-specific T cell responses in patients with SLEInsoo Kang; Fiscal Year: 2008..Of interest, studies reported an increased frequency of herpes zoster due to reactivation of varicella zoster virus (VZV) in patients with SLE and increased EBV viral loads in ..
- Developmental Disabilities in a Time of AIDSADHIKARI MIRIAM; Fiscal Year: 2004..abstract_text> ..
- CHRONIC NEUROPATHIC PAIN MECHANISMS AND MANAGEMENTMichael Rowbotham; Fiscal Year: 2004..Project II will test the hypothesis that development of chronic post-herpetic neuralgia after herpes zoster strongly depends on the severity of the initial neural injury and the quality of neural recovery...
- Compressed Autoantibody Induction Heralding AutoimmunityAndreas Reimold; Fiscal Year: 2006..The gene expression signatures of autoantibody induction that emerges from this study will characterize the earliest stages of autoimmune disease induction. ..
- DCIS--MAMMOGRAPHIC FEATURES AND PROGNOSISLaurel Habel; Fiscal Year: 2003..abstract_text> ..
- Development of the enteric nervous system: Cells & genesMichael Gershon; Fiscal Year: 2006..The invited speakers include all of the leading researchers in the field, including Professor Nicole Le Douarin. We also anticipate that many post-graduate students and post-doctoral fellows will also attend. [unreadable] [unreadable]..
- Epidemiology of Recurrent Aphthous StomatitisLorena Baccaglini; Fiscal Year: 2007..Understanding the cause of canker sores can lead to better treatments for patients affected by this condition. [unreadable] [unreadable] [unreadable]..
- Macrophage defense againt M. tuberculosisJennifer Wang; Fiscal Year: 2008..abstract_text> ..
- Investigating aging and membrane-associated T cell receptor signaling in human CDInsoo Kang; Fiscal Year: 2008..The results of this study will provide important information on enhancing immune responses in the aged populations, leading to improved protection against infections and tumors. [unreadable] [unreadable] [unreadable]..
- ROLE OF VARICELLA ZOSTER VIRUS GLYCOPROTEIN B DURING VIRTHOMAS HEINEMAN; Fiscal Year: 2003..This research may identify critical viral metabolic pathways and may ultimately lead to the development of new antiviral therapies. ..