lyme disease

Summary

Summary: An infectious disease caused by a spirochete, BORRELIA BURGDORFERI, which is transmitted chiefly by Ixodes dammini (see IXODES) and pacificus ticks in the United States and Ixodes ricinis (see IXODES) in Europe. It is a disease with early and late cutaneous manifestations plus involvement of the nervous system, heart, eye, and joints in variable combinations. The disease was formerly known as Lyme arthritis and first discovered at Old Lyme, Connecticut.

Top Publications

  1. ncbi The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America
    Gary P Wormser
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Clin Infect Dis 43:1089-134. 2006
  2. doi Lyme borreliosis
    Gerold Stanek
    Medical University of Vienna, Institute for Hygiene and Applied Immunology, Vienna, Austria
    Lancet 379:461-73. 2012
  3. pmc A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent
    Tim J Schuijt
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06420, USA
    Cell Host Microbe 10:136-46. 2011
  4. pmc The ecology of infectious disease: effects of host diversity and community composition on Lyme disease risk
    Kathleen LoGiudice
    Institute of Ecosystem Studies, Box AB, Millbrook, NY 12545, USA
    Proc Natl Acad Sci U S A 100:567-71. 2003
  5. pmc Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes
    Justin D Radolf
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Nat Rev Microbiol 10:87-99. 2012
  6. ncbi Surveillance for Lyme disease--United States, 1992-2006
    Rendi M Bacon
    Division of Vector Borne Infectious Diseases, National Center for Zoonotic Vector Borne and Enteric Diseases, Fort Collins, CO 80521, USA
    MMWR Surveill Summ 57:1-9. 2008
  7. pmc Borrelia burgdorferi OspC protein required exclusively in a crucial early stage of mammalian infection
    Kit Tilly
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, USA
    Infect Immun 74:3554-64. 2006
  8. doi Gene regulation in Borrelia burgdorferi
    D Scott Samuels
    Division of Biological Sciences and Biochemistry Program, The University of Montana, Missoula, Montana 59812, USA
    Annu Rev Microbiol 65:479-99. 2011
  9. ncbi Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease
    M S Klempner
    New England Medical Center and Tufts University School of Medicine, Boston, MA, USA
    N Engl J Med 345:85-92. 2001
  10. pmc Borrelia burgdorferi genotype predicts the capacity for hematogenous dissemination during early Lyme disease
    Gary P Wormser
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    J Infect Dis 198:1358-64. 2008

Detail Information

Publications315 found, 100 shown here

  1. ncbi The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America
    Gary P Wormser
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Clin Infect Dis 43:1089-134. 2006
    Evidence-based guidelines for the management of patients with Lyme disease, human granulocytic anaplasmosis (formerly known as human granulocytic ehrlichiosis), and babesiosis were prepared by an expert panel of the Infectious Diseases ..
  2. doi Lyme borreliosis
    Gerold Stanek
    Medical University of Vienna, Institute for Hygiene and Applied Immunology, Vienna, Austria
    Lancet 379:461-73. 2012
    Lyme borreliosis (Lyme disease) is caused by spirochaetes of the Borrelia burgdorferi sensu lato species complex, which are transmitted by ticks...
  3. pmc A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent
    Tim J Schuijt
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06420, USA
    Cell Host Microbe 10:136-46. 2011
    The Lyme disease agent Borrelia burgdorferi is primarily transmitted to vertebrates by Ixodes ticks. The classical and alternative complement pathways are important in Borrelia eradication by the vertebrate host...
  4. pmc The ecology of infectious disease: effects of host diversity and community composition on Lyme disease risk
    Kathleen LoGiudice
    Institute of Ecosystem Studies, Box AB, Millbrook, NY 12545, USA
    Proc Natl Acad Sci U S A 100:567-71. 2003
    ..g., shrews), which are capable of maintaining high disease risk when mouse density is low. Our study suggests that the preservation of vertebrate biodiversity and community composition can reduce the incidence of Lyme disease.
  5. pmc Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes
    Justin D Radolf
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Nat Rev Microbiol 10:87-99. 2012
    In little more than 30 years, Lyme disease, which is caused by the spirochaete Borrelia burgdorferi, has risen from relative obscurity to become a global public health problem and a prototype of an emerging infection...
  6. ncbi Surveillance for Lyme disease--United States, 1992-2006
    Rendi M Bacon
    Division of Vector Borne Infectious Diseases, National Center for Zoonotic Vector Borne and Enteric Diseases, Fort Collins, CO 80521, USA
    MMWR Surveill Summ 57:1-9. 2008
    b>Lyme disease is a multisystem disease that occurs in North America, Europe, and Asia. In the United States, the etiologic agent is Borrelia burgdorferi sensu stricto, a spirochete transmitted to humans by infected Ixodes scapularis and I...
  7. pmc Borrelia burgdorferi OspC protein required exclusively in a crucial early stage of mammalian infection
    Kit Tilly
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, USA
    Infect Immun 74:3554-64. 2006
    This study demonstrates a strict temporal requirement for a virulence determinant of the Lyme disease spirochete Borrelia burgdorferi during a unique point in its natural infection cycle, which alternates between ticks and small mammals...
  8. doi Gene regulation in Borrelia burgdorferi
    D Scott Samuels
    Division of Biological Sciences and Biochemistry Program, The University of Montana, Missoula, Montana 59812, USA
    Annu Rev Microbiol 65:479-99. 2011
    Borrelia burgdorferi, the spirochete that causes Lyme disease, is maintained in nature via an enzootic cycle that comprises a tick vector and a vertebrate host...
  9. ncbi Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease
    M S Klempner
    New England Medical Center and Tufts University School of Medicine, Boston, MA, USA
    N Engl J Med 345:85-92. 2001
    It is controversial whether prolonged antibiotic treatment is effective for patients in whom symptoms persist after the recommended antibiotic treatment for acute Lyme disease.
  10. pmc Borrelia burgdorferi genotype predicts the capacity for hematogenous dissemination during early Lyme disease
    Gary P Wormser
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    J Infect Dis 198:1358-64. 2008
    b>Lyme disease, the most common tickborne disease in the United States, is caused exclusively by Borrelia burgdorferi sensu stricto in North America. The present study evaluated the genotypes of >400 clinical isolates of B...
  11. pmc BosR (BB0647) governs virulence expression in Borrelia burgdorferi
    Zhiming Ouyang
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Microbiol 74:1331-43. 2009
    Summary Borrelia burgdorferi (Bb), the Lyme disease spirochaete, encodes a potential ferric uptake regulator (Fur) homologue, BosR (BB0647)...
  12. pmc Whole-genome sequences of thirteen isolates of Borrelia burgdorferi
    Steven E Schutzer
    Department of Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    J Bacteriol 193:1018-20. 2011
    Borrelia burgdorferi is a causative agent of Lyme disease in North America and Eurasia. The first complete genome sequence of B...
  13. doi Pangloss revisited: a critique of the dilution effect and the biodiversity-buffers-disease paradigm
    S E Randolph
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Parasitology 139:847-63. 2012
    ..We warn against raising a straw man, an untenable argument easily dismantled and dismissed. The intrinsic value of protecting biodiversity and ecosystem function outweighs this questionable utilitarian justification...
  14. pmc Cholesterol lipids of Borrelia burgdorferi form lipid rafts and are required for the bactericidal activity of a complement-independent antibody
    Timothy J LaRocca
    Department of Molecular Genetics and Microbiology, and Center for Infectious Diseases, Stony Brook University, Stony Brook, NY 11794, USA
    Cell Host Microbe 8:331-42. 2010
    Borrelia burgdorferi, the agent of Lyme disease, is unusual as it contains free cholesterol and cholesterol glycolipids...
  15. doi Lyme borreliosis: clinical case definitions for diagnosis and management in Europe
    G Stanek
    Medical University of Vienna, Department of Hygiene and Applied Immunology, Vienna, Austria
    Clin Microbiol Infect 17:69-79. 2011
    ..These new case definitions for European Lyme borreliosis emphasise recognition of clinical manifestations supported by relevant laboratory criteria and may be used in a clinical setting and also for epidemiological investigations...
  16. pmc Role of the surface lipoprotein BBA07 in the enzootic cycle of Borrelia burgdorferi
    Haijun Xu
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Infect Immun 78:2910-8. 2010
    Borrelia burgdorferi, the Lyme disease pathogen, dramatically alters its protein profile when it is transmitted between ticks and mammals...
  17. pmc Borrelia burgdorferi small lipoprotein Lp6.6 is a member of multiple protein complexes in the outer membrane and facilitates pathogen transmission from ticks to mice
    Kamoltip Promnares
    Department of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    Mol Microbiol 74:112-25. 2009
    ..burgdorferi persistence and transmission through a complex enzootic cycle...
  18. pmc Outer-surface protein C of the Lyme disease spirochete: a protein induced in ticks for infection of mammals
    Dorothee Grimm
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South Fourth Street, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 101:3142-7. 2004
    Environmentally responsive synthesis of surface proteins represents a hallmark of the infectious cycle of the Lyme disease agent, Borrelia burgdorferi. Here we created and analyzed a B...
  19. pmc Risk maps for range expansion of the Lyme disease vector, Ixodes scapularis, in Canada now and with climate change
    Nicholas H Ogden
    Centre for Food borne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Saint Hyacinthe, Quebec, Canada
    Int J Health Geogr 7:24. 2008
    b>Lyme disease is the commonest vector-borne zoonosis in the temperate world, and an emerging infectious disease in Canada due to expansion of the geographic range of the tick vector Ixodes scapularis...
  20. pmc A tick antioxidant facilitates the Lyme disease agent's successful migration from the mammalian host to the arthropod vector
    Sukanya Narasimhan
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell Host Microbe 2:7-18. 2007
    The tick Ixodes scapularis is an efficient vector for microbes, including the Lyme disease agent Borrelia burgdorferi. Ticks engorging on vertebrates induce recruitment of inflammatory cells to the bite site...
  21. doi A clear and present danger: tick-borne diseases in Europe
    Paul Heyman
    Research Laboratory for Vector Borne Diseases, Queen Astrid Military Hospital, Bruynstraat 1, B 1120 Brussels, Belgium
    Expert Rev Anti Infect Ther 8:33-50. 2010
    ..Anaplasma phagocytophilum, Babesia spp., tick-borne encephalitis virus, Rickettsia spp. and Crimean-Congo hemorrhagic fever virus)...
  22. ncbi The role of VlsE antigenic variation in the Lyme disease spirochete: persistence through a mechanism that differs from other pathogens
    Troy Bankhead
    Department of Biochemistry, University of Calgary, Calgary, Alberta T2N 4 N1, Canada
    Mol Microbiol 65:1547-58. 2007
    The linear plasmid, lp28-1, is required for persistent infection by the Lyme disease spirochete, Borrelia burgdorferi. This plasmid contains the vls antigenic variation locus, which has long been thought to be important for immune evasion...
  23. pmc Lyme disease
    Thomas S Murray
    Department of Pediatric, Yale University, New Haven, CT 06520 8064, USA
    Clin Lab Med 30:311-28. 2010
    b>Lyme disease, caused by the spirochete Borrelia burgdorferi, is the most common vector-borne disease in the United States...
  24. pmc The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirochete
    Jenny A Hyde
    Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M Health Science Center, College Station, TX 77843 1114, USA
    Mol Microbiol 74:1344-55. 2009
    Summary Borrelia burgdorferi, the Lyme disease spirochete, adapts as it moves between the arthropod and mammalian hosts that it infects. We hypothesize that BosR serves as a global regulator in B...
  25. pmc The bba64 gene of Borrelia burgdorferi, the Lyme disease agent, is critical for mammalian infection via tick bite transmission
    Robert D Gilmore
    Bacterial Diseases Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA
    Proc Natl Acad Sci U S A 107:7515-20. 2010
    The spirochetal agent of Lyme disease, Borrelia burgdorferi, is transmitted by bites of Ixodes ticks to mammalian reservoir hosts and humans. The mechanism(s) by which the organism is trafficked from vector to host is poorly understood...
  26. pmc Diagnosis of lyme borreliosis
    Maria E Aguero-Rosenfeld
    Department of Pathology, Division of Infectious Diseases, New York Medical College, Valhalla, NY, USA
    Clin Microbiol Rev 18:484-509. 2005
    ..Evaluation of these assays is currently being done, and there is evidence that certain of these antigens may be broadly cross-reactive with the B. burgdorferi sensu lato species causing LB in Europe...
  27. pmc A new Borrelia species defined by multilocus sequence analysis of housekeeping genes
    Gabriele Margos
    Department of Biology and Biochemistry, University of Bath, 3 South, Claverton Down, Bath BA2 7AY, United Kingdom
    Appl Environ Microbiol 75:5410-6. 2009
    ..We suggest that OspA serotype 4 strains be raised to species status and named Borrelia bavariensis sp. nov. The rooted phylogenetic trees provide novel insights into the evolutionary history of LB spirochetes...
  28. pmc Borrelia burgdorferi population kinetics and selected gene expression at the host-vector interface
    Emir Hodzic
    Center for Comparative Medicine, School of Medicine, University of California at Davis, Davis, California 95616, USA
    Infect Immun 70:3382-8. 2002
    ..Evidence of ospA transcription in skin could be found 1 day after tick attachment but not thereafter...
  29. pmc Analysis of the RpoS regulon in Borrelia burgdorferi in response to mammalian host signals provides insight into RpoS function during the enzootic cycle
    Melissa J Caimano
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Mol Microbiol 65:1193-217. 2007
    ....
  30. pmc Distinct cerebrospinal fluid proteomes differentiate post-treatment lyme disease from chronic fatigue syndrome
    Steven E Schutzer
    Department of Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, United States of America
    PLoS ONE 6:e17287. 2011
    Neurologic Post Treatment Lyme disease (nPTLS) and Chronic Fatigue (CFS) are syndromes of unknown etiology. They share features of fatigue and cognitive dysfunction, making it difficult to differentiate them...
  31. pmc Tick histamine release factor is critical for Ixodes scapularis engorgement and transmission of the lyme disease agent
    Jianfeng Dai
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    PLoS Pathog 6:e1001205. 2010
    ..These findings suggest that blocking tHRF might offer a viable strategy to complement ongoing efforts to develop vaccines to block tick feeding and transmission of tick-borne pathogens...
  32. pmc Hosts as ecological traps for the vector of Lyme disease
    F Keesing
    Department of Biology, Bard College, Annandale, NY 12504, USA
    Proc Biol Sci 276:3911-9. 2009
    ..In this study we tested whether blacklegged ticks, the vectors of Lyme disease, granulocytic anaplasmosis and babesiosis can be regulated by the species of vertebrate hosts on which they ..
  33. pmc A new animal model for studying Lyme disease spirochetes in a mammalian host-adapted state
    D R Akins
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Clin Invest 101:2240-50. 1998
    There is now substantial evidence that Borrelia burgdorferi, the Lyme disease spirochete, undergoes major alterations in antigenic composition as it cycles between its arthropod and mammalian hosts. In this report, we cultivated B...
  34. pmc Molecular interactions that enable movement of the Lyme disease agent from the tick gut into the hemolymph
    Lili Zhang
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS Pathog 7:e1002079. 2011
    Borrelia burgdorferi, the causative agent of Lyme disease, is transmitted to humans by bite of Ixodes scapularis ticks. The mechanisms by which the bacterium is transmitted from vector to host are poorly understood...
  35. pmc Population genetics, taxonomy, phylogeny and evolution of Borrelia burgdorferi sensu lato
    Gabriele Margos
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Infect Genet Evol 11:1545-63. 2011
    ....
  36. doi Vasculitis-like syndrome associated with Borrelia lusitaniae infection
    I Lopes de Carvalho
    Center for Vector and Infectious Diseases Research, Instituto Nacional de Saude Dr Ricardo Jorge, Lisbon, Portugal
    Clin Rheumatol 27:1587-91. 2008
    ..In order to prevent the occurrence of more serious disease manifestations via timely treatment, the analysis by molecular methods may be a useful approach when antibody titres are uninformative...
  37. pmc Simultaneous detection and genotyping of three genomic groups of Borrelia burgdorferi sensu lato in Dutch Ixodes ricinus ticks by characterization of the amplified intergenic spacer region between 5S and 23S rRNA genes
    S G Rijpkema
    Laboratory of Bacteriology and Antimicrobial Agents, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Clin Microbiol 33:3091-5. 1995
    ..burgdorferi sensu lato in ticks collected in the field. This technique provides new ways to study the association of genomic groups present in ticks and the risk of Lyme borreliosis...
  38. doi Prospective study on the incidence of infection by Borrelia burgdorferi sensu lato after a tick bite in a highly endemic area of Switzerland
    Delphine Huegli
    Institut de Biologie, Laboratoire d Eco Epidémiologie, Universite de Neuchatel, 2000 Neuchatel, Switzerland
    Ticks Tick Borne Dis 2:129-36. 2011
    ..9% of nymphs remained attached for more than 24h whereas only 38.3% of female ticks remained attached for more than 24h. We observed that 6.6% and 2.4% of participants bitten by infected and uninfected ticks, respectively, developed EM...
  39. pmc Oligopeptide permease A5 modulates vertebrate host-specific adaptation of Borrelia burgdorferi
    B V Subba Raju
    South Texas Center for Emerging Infectious Diseases and Department of Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USA
    Infect Immun 79:3407-20. 2011
    Borrelia burgdorferi, the agent of Lyme disease, undergoes rapid adaptive gene expression in response to signals unique to its arthropod vector or vertebrate hosts...
  40. doi Spatial dynamics of lyme disease: a review
    Mary E Killilea
    Cary Institute of Ecosystem Studies, Millbrook, NY 12545 0129, USA
    Ecohealth 5:167-95. 2008
    b>Lyme disease (LD), the most frequently reported vector-borne disease in the United States, requires that humans, infected vector ticks, and infected hosts all occur in close spatial proximity...
  41. pmc Anti-Borrelia burgdorferi antibody profile in post-Lyme disease syndrome
    Abhishek Chandra
    Department of Neurology and Neuroscience, Weill Cornell Medical College, Cornell University, New York, New York, USA
    Clin Vaccine Immunol 18:767-71. 2011
    Patients with post-Lyme disease syndrome (PLDS) report persistent symptoms of pain, fatigue, and/or concentration and memory disturbances despite antibiotic treatment for Lyme borreliosis...
  42. pmc Climate, deer, rodents, and acorns as determinants of variation in lyme-disease risk
    Richard S Ostfeld
    Institute of Ecosystem Studies, Millbrook, New York, USA
    PLoS Biol 4:e145. 2006
    ..scapularis ticks) over 13 y on several field plots within eastern deciduous forests in the epicenter of US Lyme disease (Dutchess County, New York)...
  43. doi Subjective symptoms after treatment of early Lyme disease
    Dasa Cerar
    Department of Infectious Diseases, University Medical Center Ljubljana, Slovenia
    Am J Med 123:79-86. 2010
    Controversy exists over the significance and even the existence of post-Lyme disease symptoms because of the high rate of similar background symptoms in the general population.
  44. ncbi Prevalence and incidence of antibodies to Borrelia burgdorferi and to tick-borne encephalitis virus in agricultural and forestry workers from Tuscany, Italy
    P Tomao
    Department of Occupational Medicine, Istituto Superiore per la Prevenzione e la Sicurezza del Lavoro, Via Fontana Candida 1, 00040, Monteporzio Catone Rome, Italy
    Eur J Clin Microbiol Infect Dis 24:457-63. 2005
    ..03% vs. 3.56% in the confirmatory test). No seropositivity was observed for TBE virus. Eighteen of 176 subjects who underwent a second blood test developed specific antibodies against Borrelia burgdorferi within 1 year...
  45. ncbi Late and chronic Lyme disease
    Sam T Donta
    Divisions of Infectious Disease and BioMolecular Medicine, Lyme Disease Unit, Boston University Medical Center, Boston, Massachusetts, USA
    Med Clin North Am 86:341-9, vii. 2002
    This article reviews the late and chronic manifestations of Lyme disease. Special attention is given to the chronic manifestations of the disease, detailing its pathogenesis, clinical spectrum, and laboratory criteria for the diagnosis...
  46. pmc Interleukin-10 alters effector functions of multiple genes induced by Borrelia burgdorferi in macrophages to regulate Lyme disease inflammation
    Aarti Gautam
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana, USA
    Infect Immun 79:4876-92. 2011
    ..IL-10) modulates inflammatory responses elicited in vitro and in vivo by Borrelia burgdorferi, the Lyme disease spirochete. How IL-10 modulates these inflammatory responses still remains elusive...
  47. doi Low risk of developing Borrelia burgdorferi infection in the south-east of Sweden after being bitten by a Borrelia burgdorferi-infected tick
    Linda Fryland
    Division of Clinical Immunology, Department of Clinical and Experimental Medicine, Linkoping University, S 581 85 Linkoping, Sweden
    Int J Infect Dis 15:e174-81. 2011
    ..In the current study, we investigated the prevalence of Bb in ticks that had bitten humans and the risk of developing LB from Bb-infected ticks...
  48. pmc Genetic diversity of Borrelia burgdorferi and detection of B. bissettii-like DNA in serum of north-coastal California residents
    Yvette A Girard
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California, USA
    J Clin Microbiol 49:945-54. 2011
    ..Further molecular testing of sera from residents in areas where LB is endemic is warranted to enhance our understanding of the geographic distribution and frequency of occurrence of B. bissettii-like infections...
  49. pmc Functional analysis of the Borrelia burgdorferi bba64 gene product in murine infection via tick infestation
    Toni G Patton
    Microbiology and Pathogenesis Activity, Division of Vector Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA
    PLoS ONE 6:e19536. 2011
    ..Collectively, the results of this study indicate that BBA64 functions at the salivary gland-to-host delivery interface of vector transmission and is not involved in resistance to MyD88-mediated innate immunity...
  50. doi Use of tick surveys and serosurveys to evaluate pet dogs as a sentinel species for emerging Lyme disease
    Sarah A Hamer
    Department of Fisheries and Wildlife, College of Agricultural and Natural Resources, Michigan State University, East Lansing, MI 48824, USA
    Am J Vet Res 70:49-56. 2009
    To evaluate dogs as a sentinel species for emergence of Lyme disease in a region undergoing invasion by Ixodes scapularis.
  51. pmc CsrA modulates levels of lipoproteins and key regulators of gene expression critical for pathogenic mechanisms of Borrelia burgdorferi
    S L Rajasekhar Karna
    South Texas Center for Emerging Infectious Diseases and Department of Biology, The University of Texas at San Antonio, San Antonio, Texas 78249, USA
    Infect Immun 79:732-44. 2011
    ..The further characterization of molecular basis of regulation mediated by CsrA(Bb) will provide significant insights into the pathophysiology of B. burgdorferi...
  52. pmc Borrelia burgdorferi RevA antigen binds host fibronectin
    Catherine A Brissette
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Chandler Medical Center MN469, Lexington, Kentucky 40536 0298, USA
    Infect Immun 77:2802-12. 2009
    Borrelia burgdorferi, the Lyme disease-causing spirochete, can persistently infect its vertebrate hosts for years. B...
  53. ncbi Cardiac involvement in non-human primates infected with the Lyme disease spirochete Borrelia burgdorferi
    Diego Cadavid
    Department of Neurology and Neuroscience, UMDNJ New Jersey Medical School, Newark, NJ, USA
    Lab Invest 84:1439-50. 2004
    To investigate cardiac involvement in the non-human primate (NHP) model of Lyme disease, we inoculated 39 adult Macaca mulatta with Borrelia burgdorferi sensu stricto strains N40 (BbN40) by needle (N=22, 14 immunocompetent (IC), seven ..
  54. doi Lyme disease: a review
    Adriana R Marques
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11 N234, Bethesda, MD 20892, USA
    Curr Allergy Asthma Rep 10:13-20. 2010
    b>Lyme disease is the most common vector-borne illness in the United States and is also endemic in Europe and Asia. It is caused by the spirochete Borrelia burgdorferi and transmitted by the bite of the Ixodes (deer) tick...
  55. ncbi Counterpoint: long-term antibiotic therapy improves persistent symptoms associated with lyme disease
    Raphael B Stricker
    International Lyme and Associated Diseases Society, Bethesda, MD, USA
    Clin Infect Dis 45:149-57. 2007
    Controversy exists regarding the diagnosis and treatment of Lyme disease. Patients with persistent symptoms after standard (2-4-week) antibiotic therapy for this tickborne illness have been denied further antibiotic treatment as a result ..
  56. pmc Human integrin α(3)β(1) regulates TLR2 recognition of lipopeptides from endosomal compartments
    Meghan L Marre
    Graduate Program in Immunology, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, USA
    PLoS ONE 5:e12871. 2010
    ..Adaptors and co-receptors that mediate this process, as well as the mechanisms by which these adaptors and co-receptors function, are still being discovered...
  57. pmc Borrelia burgdorferi lacking DbpBA exhibits an early survival defect during experimental infection
    Eric H Weening
    Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M Health Science Center, College Station, TX 77843, USA
    Infect Immun 76:5694-705. 2008
    ..Several Borrelia burgdorferi genes induced under mammalian host conditions have been purported to be important in Lyme disease pathogenesis based on their binding to host structures...
  58. pmc Determinants of the geographic distribution of Puumala virus and Lyme borreliosis infections in Belgium
    Catherine Linard
    Department of Geography, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Int J Health Geogr 6:15. 2007
    ..Municipalities were taken as units of analysis...
  59. pmc Demonstration of OspC type diversity in invasive human lyme disease isolates and identification of previously uncharacterized epitopes that define the specificity of the OspC murine antibody response
    Christopher G Earnhart
    Department of Microbiology and Immunology, Medical College of Virginia at Virginia Commonwealth University, Richmond, VA 23298 0678, USA
    Infect Immun 73:7869-77. 2005
    Outer surface protein C (OspC) of the Lyme disease spirochetes is an important virulence factor that has potential utility for vaccine development...
  60. pmc T-cell-independent responses to Borrelia burgdorferi are critical for protective immunity and resolution of lyme disease
    M D McKisic
    Center for Comparative Medicine, University of California, Davis, California 95616, USA
    Infect Immun 68:5190-7. 2000
    ..These data demonstrate that B-cell activation during a T-cell-independent response may be critical for resolution of arthritis and carditis and that protective antibodies are generated during this response...
  61. pmc Role of acetyl-phosphate in activation of the Rrp2-RpoN-RpoS pathway in Borrelia burgdorferi
    Haijun Xu
    Institute of Insect Science, Zhejiang University, Hangzhou, China
    PLoS Pathog 6:e1001104. 2010
    Borrelia burgdorferi, the Lyme disease spirochete, dramatically alters its transcriptome and proteome as it cycles between the arthropod vector and mammalian host...
  62. ncbi The utility of "Google Trends" for epidemiological research: Lyme disease as an example
    Ari Seifter
    Lyme Disease Research Foundation of Maryland, 10755 Falls Road, Lutherville, MD 21093, USA
    Geospat Health 4:135-7. 2010
    ..We report briefly on exploring this resource using Lyme disease as an example because it has well-described seasonal and geographic patterns...
  63. doi Geographic and temporal variations in population dynamics of Ixodes ricinus and associated Borrelia infections in The Netherlands
    Fedor Gassner
    Laboratory of Entomology, Wageningen University and Research Centre, Wageningen, The Netherlands
    Vector Borne Zoonotic Dis 11:523-32. 2011
    ..The study shows that Borrelia-infected ticks are present in many forest and dune areas in The Netherlands and suggests that in such biotopes, which are used for a wide variety of recreational activities, the infection risk is high...
  64. pmc Identification and function of the RNA chaperone Hfq in the Lyme disease spirochete Borrelia burgdorferi
    Meghan C Lybecker
    Division of Biological Sciences, The University of Montana, Missoula, MT 59812 4824, USA
    Mol Microbiol 78:622-35. 2010
    ..We have identified and characterized an atypical Hfq required for gene regulation and infectivity in the Lyme disease spirochete Borrelia burgdorferi. Sequence analyses of the putative B...
  65. pmc Ineffectiveness of tigecycline against persistent Borrelia burgdorferi
    Stephen W Barthold
    Center for Comparative Medicine, School of Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA
    Antimicrob Agents Chemother 54:643-51. 2010
    ..burgdorferi genes. These results extended previous studies with ceftriaxone, indicating that antibiotic treatment is unable to clear persisting spirochetes, which remain viable and infectious, but are nondividing or slowly dividing...
  66. pmc Essential role of the response regulator Rrp2 in the infectious cycle of Borrelia burgdorferi
    Bethany K Boardman
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Infect Immun 76:3844-53. 2008
    Alteration of surface lipoprotein profiles is a key strategy that the Lyme disease pathogen, Borrelia burgdorferi, has evolved to be maintained within its enzootic cycle between arthropods and mammals...
  67. pmc Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks
    Star M Dunham-Ems
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    J Clin Invest 119:3652-65. 2009
    b>Lyme disease is caused by transmission of the spirochete Borrelia burgdorferi from ticks to humans. Although much is known about B. burgdorferi replication, the routes and mechanisms by which it disseminates within the tick remain unclear...
  68. doi Prevalence and geographic distribution of Dirofilaria immitis, Borrelia burgdorferi, Ehrlichia canis, and Anaplasma phagocytophilum in dogs in the United States: results of a national clinic-based serologic survey
    Dwight Bowman
    Department of Microbiology and Immunology, Cornell College of Veterinary Medicine, C4 119 Veterinary Medical Center, Ithaca, NY 14853, United States
    Vet Parasitol 160:138-48. 2009
    ..Dogs can serve as sentinels to identify the presence of vector-borne disease agents of both veterinary and public health significance...
  69. pmc Role of the BBA64 locus of Borrelia burgdorferi in early stages of infectivity in a murine model of Lyme disease
    Mahulena Maruskova
    South Texas Center for Emerging Infectious Diseases and Department of Biology, The University of Texas at San Antonio, San Antonio, Texas 7824, USA
    Infect Immun 76:391-402. 2008
    Borrelia burgdorferi, the causative agent of Lyme disease, undergoes rapid adaptive gene expression in response to environmental signals encountered during different stages of its life cycle in the arthropod vector or the mammalian host...
  70. doi Transcriptional interplay among the regulators Rrp2, RpoN and RpoS in Borrelia burgdorferi
    Zhiming Ouyang
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Microbiology 154:2641-58. 2008
    ..Although several known B. burgdorferi virulence determinants were regulated by the RpoN-RpoS pathway, a defined function has yet to be ascribed to most of the genes substantially regulated by Rrp2, RpoN and RpoS...
  71. ncbi Post-Lyme borreliosis syndrome: a meta-analysis of reported symptoms
    Victoria Cairns
    Clinical Trial Service Unit, University of Oxford, UK
    Int J Epidemiol 34:1340-5. 2005
    ..This meta-analysis compares the prevalence of fatigue, musculoskeletal pain, and neurocognitive difficulties in patients who have had Lyme borreliosis (LB) and control subjects without LB...
  72. ncbi Effect of tick removal on transmission of Borrelia burgdorferi and Ehrlichia phagocytophila by Ixodes scapularis nymphs
    F des Vignes
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06520-0834, USA
    J Infect Dis 183:773-8. 2001
    ..pathogen transmission was studied for individual ticks infected with either laboratory or field strains of the Lyme disease spirochete Borrelia burgdorferi and field strains of Ehrlichia phagocytophila, an agent of human granulocytic ..
  73. doi Skin manifestations of lyme borreliosis: diagnosis and management
    Robert R Mullegger
    Department of Dermatology, Central Hospital Wiener Neustadt, Wiener Neustadt, Austria
    Am J Clin Dermatol 9:355-68. 2008
    ..Other first-line antibacterials are amoxicillin and cefuroxime axetil. Erythema migrans is treated for 2 weeks, lymphocytoma for 3-4 weeks, and acrodermatitis for at least 4 weeks...
  74. pmc Tick saliva reduces adherence and area of human neutrophils
    Ruth R Montgomery
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Infect Immun 72:2989-94. 2004
    During natural infection with the agent of Lyme disease, Borrelia burgdorferi, spirochetes are delivered with vector saliva, which contains anti-inflammatory and antihemostatic activities...
  75. pmc Biology of infection with Borrelia burgdorferi
    Kit Tilly
    Laboratory of Zoonotic Pathogens, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA
    Infect Dis Clin North Am 22:217-34, v. 2008
    ..Although infection of these natural hosts does not lead to disease, infection of humans can result in Lyme disease as a consequence of the human immunopathologic response to B burgdorferi...
  76. pmc Assessment of decorin-binding protein A to the infectivity of Borrelia burgdorferi in the murine models of needle and tick infection
    Jon S Blevins
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    BMC Microbiol 8:82. 2008
    Decorin-binding proteins (Dbps) A and B of Borrelia burgdorferi, the agent of Lyme disease, are surface-exposed lipoproteins that presumably bind to the extracellular matrix proteoglycan, decorin. B...
  77. pmc Molecular characterization of the Borrelia burgdorferi in vivo-essential protein PncA
    Mollie W Jewett
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Microbiology 157:2831-40. 2011
    ..Mammals lack nicotinamidases and therefore PncA may serve as a therapeutic target for Lyme disease. Contrary to the in vivo importance of PncA, the current annotation for the pncA ORF suggests that the encoded ..
  78. ncbi Increased expression of Borrelia burgdorferi vlsE in response to human endothelial cell membranes
    C R Hudson
    Antimicrobial Resistance Research Unit, ARS, SAA, USDA, Russell Research Center, 950 College Station Road, Athens, GA 30605, USA
    Mol Microbiol 41:229-39. 2001
    ..Southern blots probed with the vlsE promoter/operator region indicated that part or all of this sequence could be found on other B. burgdorferi plasmids...
  79. ncbi Plasmid requirements for infection of ticks by Borrelia burgdorferi
    Keith O Strother
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Vector Borne Zoonotic Dis 5:237-45. 2005
    ..This study has pinpointed specific plasmids whose absence is deleterious to infecting nymphal tick guts and salivary glands...
  80. doi Prediction of Lyme meningitis based on a logistic regression model using clinical and cerebrospinal fluid analysis: a European study
    David Tuerlinckx
    Departement de Pediatrie, Universitaires de Mont Godinne, Yvoir, Belgium
    Pediatr Infect Dis J 28:394-7. 2009
    ..No similar model has ever been proposed for European patients. The objective of our study was to develop a prediction model to differentiate LM from NLAM based on clinical and CSF biologic data...
  81. pmc Delays and diversions mark the development of B cell responses to Borrelia burgdorferi infection
    Christine J Hastey
    Graduate Group in Microbiology, University of California, Davis, Davis, CA 95616, USA
    J Immunol 188:5612-22. 2012
    B cell responses modulate disease during infection with Borrelia burgdorferi, the causative agent of Lyme disease, but are unable to clear the infection. Previous studies have demonstrated that B...
  82. pmc The OspE-related proteins inhibit complement deposition and enhance serum resistance of Borrelia burgdorferi, the lyme disease spirochete
    Melisha R Kenedy
    Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Infect Immun 79:1451-7. 2011
    Borrelia burgdorferi, the Lyme disease spirochete, binds the host complement inhibitors factor H (FH) and FH-like protein 1 (FHL-1). Binding of FH/FHL-1 by the B...
  83. pmc C-terminal invariable domain of VlsE is immunodominant but its antigenicity is scarcely conserved among strains of Lyme disease spirochetes
    F T Liang
    Department of Parasitology, Tulane Regional Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
    Infect Immun 69:3224-31. 2001
    ..inoculation were positive by the Ct ELISA, while only 5 of 18 serum samples from dogs clinically diagnosed with Lyme disease contained detectable anti-Ct antibody...
  84. doi Comparison of post-Lyme Borreliosis symptoms in erythema migrans patients with positive and negative Borrelia burgdorferi sensu lato skin culture
    Daša Stupica
    Department of Infectious Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia
    Vector Borne Zoonotic Dis 11:883-9. 2011
    ..Limited data exist on differences of erythema migrans patients with either positive or negative Borrelia burgdorferi sensu lato skin culture...
  85. pmc Invasion of eukaryotic cells by Borrelia burgdorferi requires β(1) integrins and Src kinase activity
    Jing Wu
    407 Reynolds Medical Building, Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M Health Science Center, College Station, TX 77843 1114, USA
    Infect Immun 79:1338-48. 2011
    b>Lyme disease, caused by the bacterium Borrelia burgdorferi, is the most widespread tick-borne infection in the northern hemisphere that results in a multistage disorder with concomitant pathology, including arthritis...
  86. pmc Genotypic variation and mixtures of Lyme Borrelia in Ixodes ticks from North America and Europe
    Chris D Crowder
    Ibis Biosciences, Carlsbad, California, United States of America
    PLoS ONE 5:e10650. 2010
    b>Lyme disease, caused by various species of Borrelia, is transmitted by Ixodes ticks in North America and Europe. Studies have shown the genotype of Borrelia burgdorferi sensu stricto (s.s.) or the species of B. burgdorferi sensu lato (s.l...
  87. doi Detection of Borrelia burgdorferi sensu lato DNA by PCR in serum of patients with clinical symptoms of Lyme borreliosis
    Iolanda Santino
    Department of Public Health Sciences, Sapienza University of Rome, Rome, Italy
    FEMS Microbiol Lett 283:30-5. 2008
    ..burgdorferi s.l. and Borrelia genospecies DNAs in serum samples collected from patients showing Lyme disease symptoms. Of 265 serum samples of patients included in this study, 7.5% were positive, 1...
  88. pmc Treg cell numbers and function in patients with antibiotic-refractory or antibiotic-responsive Lyme arthritis
    Shiqian Shen
    Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Arthritis Rheum 62:2127-37. 2010
    ..In a murine model of antibiotic-refractory Lyme arthritis, the numbers of Treg cells are dramatically reduced. The aim of this study was to examine Treg cell numbers and function in patients with antibiotic-refractory Lyme arthritis...
  89. doi P66 porins are present in both Lyme disease and relapsing fever spirochetes: a comparison of the biophysical properties of P66 porins from six Borrelia species
    Iván Bárcena-Uribarri
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, Wurzburg, Germany
    Biochim Biophys Acta 1798:1197-203. 2010
    The genus Borrelia is the cause of the two human diseases: Lyme disease (LD) and relapsing fever (RF). Both LD and RF Borrelia species are obligate parasites and are dependent on nutrients provided by their hosts...
  90. doi Lyme borreliosis in dogs and humans in the USA
    Susan E Little
    Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA
    Trends Parasitol 26:213-8. 2010
    ....
  91. doi Persistence of borrelial DNA in the joints of Borrelia burgdorferi-infected mice after ceftriaxone treatment
    Heta Yrjänäinen
    Department of Medical Microbiology and Immunology, University of Turku, Finland
    APMIS 118:665-73. 2010
    ..In conclusion, these results combined with earlier results suggest that the joint or a tissue adjacent to the joint is the niche of persisting B. burgdorferi in ceftriaxone-treated mice...
  92. ncbi Ecological niche modeling of lyme disease in British Columbia, Canada
    Sunny Mak
    Epidemiology Services, British Columbia Centre for Disease Control, 655 West 12th Avenue, Vancouver, BC, Canada, V5Z 4R4
    J Med Entomol 47:99-105. 2010
    ..pacificus (Cooley & Kohls), and Ixodes angustus (Neumann), the bacterium and primary tick vectors for Lyme disease, in British Columbia (BC), Canada...
  93. pmc Infection and inflammation in skeletal muscle from nonhuman primates infected with different genospecies of the Lyme disease spirochete Borrelia burgdorferi
    Diego Cadavid
    Department of Neuroscience, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    Infect Immun 71:7087-98. 2003
    ..To investigate muscle involvement in the nonhuman primate (NHP) model of Lyme disease, 16 adult Macaca mulatta animals inoculated with strain N40 of B...
  94. ncbi Evidence-based guidelines for the management of Lyme disease
    Daniel Cameron
    ILADS, P O Box 341461, Bethesda, MD 20827 1461, USA
    Expert Rev Anti Infect Ther 2:S1-13. 2004
    This report, completed in November 2003, is intended to serve as a resource for physicians, public health officials and organizations involved in the evaluation and treatment of Lyme disease.
  95. pmc Deletion of BBA64, BBA65, and BBA66 loci does not alter the infectivity of Borrelia burgdorferi in the murine model of Lyme disease
    Mahulena Maruskova
    South Texas Center for Emerging Infectious Diseases and Department of Biology, The University of Texas at San Antonio, San Antonio, Texas 78249, USA
    Infect Immun 76:5274-84. 2008
    Borrelia burgdorferi, the causative agent of Lyme disease, alters its gene expression in response to highly disparate environmental signals encountered in its tick vector versus vertebrate hosts...
  96. ncbi Consequences of treatment delay in Lyme disease
    Daniel J Cameron
    J Eval Clin Pract 13:470-2. 2007
  97. pmc Impact of clinical variables on Borrelia burgdorferi-specific antibody seropositivity in acute-phase sera from patients in North America with culture-confirmed early Lyme disease
    Gary P Wormser
    Department of Medicine, Division of Infectious Diseases, Munger Pavilion Room 245, New York Medical College, Valhalla, NY 10595, USA
    Clin Vaccine Immunol 15:1519-22. 2008
    Erythema migrans, the most common manifestation of Lyme disease, has been associated with highly variable rates of seropositivity for antibodies to Borrelia burgdorferi...
  98. ncbi Lyme disease: scratching the surface
    Steven E Phillips
    Lancet 366:1771. 2005
  99. pmc Cloning of a salivary gland metalloprotease and characterization of gelatinase and fibrin(ogen)lytic activities in the saliva of the Lyme disease tick vector Ixodes scapularis
    Ivo M B Francischetti
    Medical Entomology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Room 126, Building 4, 4 Center Drive, MSC 0425, Bethesda, MD 20892 0425, USA
    Biochem Biophys Res Commun 305:869-75. 2003
    ..This is the first description of such activity in tick saliva and its role in tick feeding and Borrelia transmission is discussed...
  100. ncbi Microbiological and serological diagnosis of Lyme borreliosis
    Bettina Wilske
    Max von Pettenkofer Institute, University of Munich, National Reference Centre for Borreliae, Munich, Germany
    FEMS Immunol Med Microbiol 49:13-21. 2007
    ..Cerebrospinal fluid is positive in only 10-30%. Methods that are not recommended for diagnostic purposes include antigen tests in body fluids, PCR of urine and lymphocyte transformation tests...
  101. pmc Decreased up-regulation of the interleukin-12Rbeta2-chain and interferon-gamma secretion and increased number of forkhead box P3-expressing cells in patients with a history of chronic Lyme borreliosis compared with asymptomatic Borrelia-exposed individual
    S Jarefors
    Division of Clinical Immunology, Faculty of Health Sciences, University of Linkoping, Sweden
    Clin Exp Immunol 147:18-27. 2007
    ..In addition, regulatory T cells might also play a role, by immunosuppression, in the development of chronic LB...

Research Grants91

  1. MOLECULAR GENETICS OF LYME ARTHRITIS SUSCEPTIBILITY
    JANIS WEIS; Fiscal Year: 2009
    ..Identification of the genes that regulate disease severity will provide insight into the mechanism of arthritis development and may be extended to other inflammatory pathologies. ..
  2. Biophysics of the morphology and motility of Borrelia burgdorferi in diverse envi
    Charles W Wolgemuth; Fiscal Year: 2010
    ..If untreated, Lyme disease can lead to a wide array of complications typically involving the heart, joints, or nervous system...
  3. GAMMA DELTA T CELLS IN LYME ARTHRITIS
    Ralph Budd; Fiscal Year: 2009
    b>Lyme Disease is the most common vector-borne illness in the U.S. and is caused by transmission of the spirochete, Borrelia burgdorferi, via the tick Ixodes scapularis...
  4. GAMMA DELTA T CELLS IN LYME ARTHRITIS
    Ralph C Budd; Fiscal Year: 2010
    b>Lyme Disease is the most common vector-borne illness in the U.S. and is caused by transmission of the spirochete, Borrelia burgdorferi, via the tick Ixodes scapularis...
  5. RpoS-mediated virulence regulation in Borrelia burgdorferi
    JON SCOTT BLEVINS; Fiscal Year: 2010
    During its natural lifecycle, the Lyme disease spirochete, Borrelia burgdorferi, occupies both an arthropod tick vector and a mammalian host...
  6. LYME DISEASE IN WESTERN USA--ECOLOGY AND EPIDEMIOLOGY
    Robert Lane; Fiscal Year: 1993
    The broad objectives of this research are to expand ongoing studies of the mechanisms and routes by which the Lyme disease (LD) spirochete, Borrelia burgdorferi (Bb), is maintained and distributed among wildlife and humans in a highly ..
  7. LYME DISEASE IN WESTERN USA--ECOLOGY AND EPIDEMIOLOGY
    Robert Lane; Fiscal Year: 1992
    The broad objectives of this research are to investigate further the mechanisms whereby the Lyme disease (LD) spirochete, Borrelia burgdorferi (Bb), is perpetuated and disseminated in natural foic including modes of transmission to humans ..
  8. LYME DISEASE IN WESTERN USA: ECOLOGY AND EPIDEMIOLOGY
    Robert Lane; Fiscal Year: 2004
    ..The broad objectives of this research are to determine environmental correlates of natural foci of the Lyme disease (LD) spirochete, Borrelia burgdorferi sensu stricto (Bb ss) and closely related spirochetes in the Bb sensu ..
  9. CHRONIC LYME ARTHRITIS--IS THIS AUTOIMMUNITY?
    Brigitte Huber; Fiscal Year: 2000
    b>Lyme disease is a multi-faceted illness, initiated upon infection with the spirochete borrelia burgdorferi (Bb)...
  10. The role of Borrelia burgdorferi chemotoxis in the pathogenesis of Lyme disease
    Md Motaleb; Fiscal Year: 2007
    b>Lyme disease is the most prevalent arthropod borne infection in the United States. The disease is caused by the spirochete Borrelia burgdorferi, which is transmitted to humans via infected Ixodes ticks...
  11. LYME ARTHRITIS: A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 1993
    b>Lyme disease, which affects both children and adults, is caused by the tickborne spirochete, Borrelia burgdorferi...
  12. Suppressor of Cytokine Signaling and Control of Inflammation in Lyme Disease
    VIDA DENNIS; Fiscal Year: 2007
    b>Lyme disease, caused by the spirochete Borrelia burgdorferi, is an emerging infectious disease, and therefore, of major public health significance...
  13. BAIT VACCINE AGAINST LYME BORRELIOSIS
    Maria Gomes Solecki; Fiscal Year: 2007
    b>Lyme disease is caused by the spirochete Borrelia burgdorferi. This zoonosis is the most prevalent vector borne infectious disease in the United States and Europe and it continues to grow geographically...
  14. Chronic Lyme Arthritis: Is this Autoimmunity?
    Brigitte Huber; Fiscal Year: 2005
    b>Lyme disease is a multifaceted illness, initiated upon infection with the spirochete Borrelia burgdorferi (Bb)...
  15. BORRELIA BURGDORFERI MITOGEN IN DEVELOPMENT OF ARTHRITIS
    Janis J Weis; Fiscal Year: 2010
    ..Project Narrative: Two distinct types of responses have been identified in mice infected with the agent of Lyme disease, Borrelia burgdorferi...
  16. BORRELIA BURGDORFERI MITOGEN IN DEVELOPMENT OF ARTHRITIS
    JANIS WEIS; Fiscal Year: 2009
    ..Project Narrative: Two distinct types of responses have been identified in mice infected with the agent of Lyme disease, Borrelia burgdorferi...
  17. HEALTH BURDERN OF COINFECTING DEER ASSOCIATED ZOONOSES
    Peter Krause; Fiscal Year: 2001
    Although public attention has focused largely on Lyme disease, an array of spirochetal, protozoan, viral and rickettsial pathogens concurrently infect residents of sites in the eastern US in which deer are abundant...
  18. DbpA/B proteins of Borrelia burgdorferi & Lyme arthritis
    Nikhat Parveen; Fiscal Year: 2005
    b>Lyme disease presents a unique clinical system to study cellular and molecular mecahnisms responsible for chronic inflammatory diseases...
  19. Pathogenesis of Borrelia burgdorferi induced arthritis
    Linden Hu; Fiscal Year: 2006
    DESCRIPTION (provided by the applicant): Arthritis is a late manifestation of Lyme disease. Allowed to progress untreated, Lyme arthritis can result in a severe, erosive arthritis...
  20. Biodiversity, Habitat Fragmentation, & Lyme Disease Risk
    RICHARD OSTFELD; Fiscal Year: 2006
    ..and the ecological landscapes in which vectors, pathogens, hosts, and humans interact to affect exposure to Lyme disease. We focus on Lyme disease because of its high incidence, widespread distribution, large body of ecological and ..
  21. Prevention of Lyme Disease in Connecticut
    Matthew Cartter; Fiscal Year: 2007
    The emergence of Lyme disease (LD) as a public health problem in Connecticut over the last 28 years is due to the increased risk of tick bites among persons who live increasingly in suburban and rural areas near woodlands in Connecticut...
  22. Borrelia burgdorferi tick phase genes and Lyme disease pathogenesis
    IRA S SCHWARTZ; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Lyme disease, the most commonly reported arthropod-borne disease in the United States, is caused by infection with the spirochete, Borrelia burgdorferi. Maintenance of B...
  23. Biodiversity, Habitat Fragmentation, & Lyme Disease Risk
    RICHARD OSTFELD; Fiscal Year: 2003
    ..and the ecological landscapes in which vectors, pathogens, hosts, and humans interact to affect exposure to Lyme disease. We focus on Lyme disease because of its high incidence, widespread distribution, large body of ecological and ..
  24. MOLECULAR GENETICS OF LYME ARTHRITIS SUSCEPTIBILITY
    Janis J Weis; Fiscal Year: 2010
    ..Identification of the genes that regulate disease severity will provide insight into the mechanism of arthritis development and may be extended to other inflammatory pathologies. ..
  25. GAMMA DELTA T CELLS IN LYME ARTHRITIS
    Ralph Budd; Fiscal Year: 2005
    b>Lyme disease is the most common vector-borne disease in the United States. It is caused by the spirochete Borrelia burgdorferi and transmitted by lxodes ticks...