lyme disease

Summary

Summary: An infectious disease caused by a spirochete, BORRELIA BURGDORFERI, which is transmitted chiefly by Ixodes dammini (see IXODES) and pacificus ticks in the United States and Ixodes ricinis (see IXODES) in Europe. It is a disease with early and late cutaneous manifestations plus involvement of the nervous system, heart, eye, and joints in variable combinations. The disease was formerly known as Lyme arthritis and first discovered at Old Lyme, Connecticut.

Top Publications

  1. ncbi The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America
    Gary P Wormser
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Clin Infect Dis 43:1089-134. 2006
  2. ncbi Lyme borreliosis
    Gerold Stanek
    Medical University of Vienna, Institute for Hygiene and Applied Immunology, Vienna, Austria
    Lancet 379:461-73. 2012
  3. pmc Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes
    Justin D Radolf
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Nat Rev Microbiol 10:87-99. 2012
  4. pmc The ecology of infectious disease: effects of host diversity and community composition on Lyme disease risk
    Kathleen LoGiudice
    Institute of Ecosystem Studies, Box AB, Millbrook, NY 12545, USA
    Proc Natl Acad Sci U S A 100:567-71. 2003
  5. ncbi The expanding Lyme Borrelia complex--clinical significance of genomic species?
    G Stanek
    Institute for Hygiene and Applied Immunology, Medical University of Vienna, Vienna, Austria
    Clin Microbiol Infect 17:487-93. 2011
  6. pmc Genome stability of Lyme disease spirochetes: comparative genomics of Borrelia burgdorferi plasmids
    Sherwood R Casjens
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
    PLoS ONE 7:e33280. 2012
  7. pmc Risk maps for range expansion of the Lyme disease vector, Ixodes scapularis, in Canada now and with climate change
    Nicholas H Ogden
    Centre for Food borne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Saint Hyacinthe, Quebec, Canada
    Int J Health Geogr 7:24. 2008
  8. pmc A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent
    Tim J Schuijt
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06420, USA
    Cell Host Microbe 10:136-46. 2011
  9. pmc Whole-genome sequences of thirteen isolates of Borrelia burgdorferi
    Steven E Schutzer
    Department of Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    J Bacteriol 193:1018-20. 2011
  10. pmc Human risk of infection with Borrelia burgdorferi, the Lyme disease agent, in eastern United States
    Maria A Diuk-Wasser
    Yale School of Public Health, New Haven, Connecticut, USA
    Am J Trop Med Hyg 86:320-7. 2012

Detail Information

Publications351 found, 100 shown here

  1. ncbi The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America
    Gary P Wormser
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Clin Infect Dis 43:1089-134. 2006
    Evidence-based guidelines for the management of patients with Lyme disease, human granulocytic anaplasmosis (formerly known as human granulocytic ehrlichiosis), and babesiosis were prepared by an expert panel of the Infectious Diseases ..
  2. ncbi Lyme borreliosis
    Gerold Stanek
    Medical University of Vienna, Institute for Hygiene and Applied Immunology, Vienna, Austria
    Lancet 379:461-73. 2012
    Lyme borreliosis (Lyme disease) is caused by spirochaetes of the Borrelia burgdorferi sensu lato species complex, which are transmitted by ticks...
  3. pmc Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes
    Justin D Radolf
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Nat Rev Microbiol 10:87-99. 2012
    In little more than 30 years, Lyme disease, which is caused by the spirochaete Borrelia burgdorferi, has risen from relative obscurity to become a global public health problem and a prototype of an emerging infection...
  4. pmc The ecology of infectious disease: effects of host diversity and community composition on Lyme disease risk
    Kathleen LoGiudice
    Institute of Ecosystem Studies, Box AB, Millbrook, NY 12545, USA
    Proc Natl Acad Sci U S A 100:567-71. 2003
    ..g., shrews), which are capable of maintaining high disease risk when mouse density is low. Our study suggests that the preservation of vertebrate biodiversity and community composition can reduce the incidence of Lyme disease.
  5. ncbi The expanding Lyme Borrelia complex--clinical significance of genomic species?
    G Stanek
    Institute for Hygiene and Applied Immunology, Medical University of Vienna, Vienna, Austria
    Clin Microbiol Infect 17:487-93. 2011
    Ten years after the discovery of spirochaetes as agents of Lyme disease in 1982 in the USA, three genomic species had diverged from the phenotypically heterogeneous strains of Borrelia burgdorferi isolated in North America and Europe: ..
  6. pmc Genome stability of Lyme disease spirochetes: comparative genomics of Borrelia burgdorferi plasmids
    Sherwood R Casjens
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
    PLoS ONE 7:e33280. 2012
    b>Lyme disease is the most common tick-borne human illness in North America...
  7. pmc Risk maps for range expansion of the Lyme disease vector, Ixodes scapularis, in Canada now and with climate change
    Nicholas H Ogden
    Centre for Food borne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Saint Hyacinthe, Quebec, Canada
    Int J Health Geogr 7:24. 2008
    b>Lyme disease is the commonest vector-borne zoonosis in the temperate world, and an emerging infectious disease in Canada due to expansion of the geographic range of the tick vector Ixodes scapularis...
  8. pmc A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent
    Tim J Schuijt
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06420, USA
    Cell Host Microbe 10:136-46. 2011
    The Lyme disease agent Borrelia burgdorferi is primarily transmitted to vertebrates by Ixodes ticks. The classical and alternative complement pathways are important in Borrelia eradication by the vertebrate host...
  9. pmc Whole-genome sequences of thirteen isolates of Borrelia burgdorferi
    Steven E Schutzer
    Department of Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    J Bacteriol 193:1018-20. 2011
    Borrelia burgdorferi is a causative agent of Lyme disease in North America and Eurasia. The first complete genome sequence of B...
  10. pmc Human risk of infection with Borrelia burgdorferi, the Lyme disease agent, in eastern United States
    Maria A Diuk-Wasser
    Yale School of Public Health, New Haven, Connecticut, USA
    Am J Trop Med Hyg 86:320-7. 2012
    ..of human risk for infection with Borrelia burgdorferi sensu stricto, the tick-borne pathogen that causes Lyme disease, was mapped for the eastern United States...
  11. ncbi The Lyme disease agent exploits a tick protein to infect the mammalian host
    Nandhini Ramamoorthi
    Sections of Rheumatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 436:573-7. 2005
    The Lyme disease agent, Borrelia burgdorferi, is maintained in a tick-mouse cycle. Here we show that B. burgdorferi usurps a tick salivary protein, Salp15 (ref. 3), to facilitate the infection of mice...
  12. pmc Outer-surface protein C of the Lyme disease spirochete: a protein induced in ticks for infection of mammals
    Dorothee Grimm
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South Fourth Street, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 101:3142-7. 2004
    Environmentally responsive synthesis of surface proteins represents a hallmark of the infectious cycle of the Lyme disease agent, Borrelia burgdorferi. Here we created and analyzed a B...
  13. ncbi Biodiversity and Lyme disease: dilution or amplification?
    N H Ogden
    Centre for Foodborne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada Agence de la santé publique du Canada, 3200 Sicotte, Saint Hyacinthe, Quebec, Canada
    Epidemics 1:196-206. 2009
    Reduced Lyme disease risk by the 'dilution effect' is often cited as an example of biodiversity providing 'ecosystem services' to public health...
  14. ncbi Sequence typing reveals extensive strain diversity of the Lyme borreliosis agents Borrelia burgdorferi in North America and Borrelia afzelii in Europe
    Jonas Bunikis
    Department of Microbiology, B240 Medical Sciences I, University of California Irvine, Irvine, CA 92697 4025, USA
    Microbiology 150:1741-55. 2004
    ..burgdorferi. It is concluded that B. burgdorferi and B. afzelii have greater genetic diversity than had previously been estimated, and that the IGS locus alone is sufficient for strain typing and phylogenetic studies...
  15. ncbi Gene regulation in Borrelia burgdorferi
    D Scott Samuels
    Division of Biological Sciences and Biochemistry Program, The University of Montana, Missoula, Montana 59812, USA
    Annu Rev Microbiol 65:479-99. 2011
    Borrelia burgdorferi, the spirochete that causes Lyme disease, is maintained in nature via an enzootic cycle that comprises a tick vector and a vertebrate host...
  16. pmc MLST of housekeeping genes captures geographic population structure and suggests a European origin of Borrelia burgdorferi
    Gabriele Margos
    Departments of Biology and Biochemistry and Mathematical Sciences, University of Bath, Bath BA2 7AY, United Kingdom
    Proc Natl Acad Sci U S A 105:8730-5. 2008
    ..burgdorferi correspond to genetically distinct populations. Importantly, the MLST data suggest that B. burgdorferi originated in Europe rather than in North America as proposed previously...
  17. pmc Detailed analysis of sequence changes occurring during vlsE antigenic variation in the mouse model of Borrelia burgdorferi infection
    Loic Coutte
    Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, Texas, United States of America
    PLoS Pathog 5:e1000293. 2009
    b>Lyme disease Borrelia can infect humans and animals for months to years, despite the presence of an active host immune response...
  18. pmc A tick antioxidant facilitates the Lyme disease agent's successful migration from the mammalian host to the arthropod vector
    Sukanya Narasimhan
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell Host Microbe 2:7-18. 2007
    The tick Ixodes scapularis is an efficient vector for microbes, including the Lyme disease agent Borrelia burgdorferi. Ticks engorging on vertebrates induce recruitment of inflammatory cells to the bite site...
  19. ncbi Surveillance for Lyme disease--United States, 1992-2006
    Rendi M Bacon
    Division of Vector Borne Infectious Diseases, National Center for Zoonotic Vector Borne and Enteric Diseases, Fort Collins, CO 80521, USA
    MMWR Surveill Summ 57:1-9. 2008
    b>Lyme disease is a multisystem disease that occurs in North America, Europe, and Asia. In the United States, the etiologic agent is Borrelia burgdorferi sensu stricto, a spirochete transmitted to humans by infected Ixodes scapularis and I...
  20. pmc Pervasive recombination and sympatric genome diversification driven by frequency-dependent selection in Borrelia burgdorferi, the Lyme disease bacterium
    James Haven
    Department of Biology, The Graduate Center, City University of New York, New York, New York 10016, USA
    Genetics 189:951-66. 2011
    ..Natural populations of Borrelia burgdorferi, the bacterial agent of Lyme disease, consist of diverse genomic groups co-infecting single individual vertebrate hosts and tick vectors...
  21. pmc OspC is potent plasminogen receptor on surface of Borrelia burgdorferi
    Ozlem Onder
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 287:16860-8. 2012
    ..proteases are crucial for the successful infection of vertebrates by several pathogens, including the Lyme disease spirochete bacterium, Borrelia burgdorferi. B...
  22. ncbi A clear and present danger: tick-borne diseases in Europe
    Paul Heyman
    Research Laboratory for Vector Borne Diseases, Queen Astrid Military Hospital, Bruynstraat 1, B 1120 Brussels, Belgium
    Expert Rev Anti Infect Ther 8:33-50. 2010
    ..Anaplasma phagocytophilum, Babesia spp., tick-borne encephalitis virus, Rickettsia spp. and Crimean-Congo hemorrhagic fever virus)...
  23. pmc Borrelia burgdorferi OspC protein required exclusively in a crucial early stage of mammalian infection
    Kit Tilly
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, USA
    Infect Immun 74:3554-64. 2006
    This study demonstrates a strict temporal requirement for a virulence determinant of the Lyme disease spirochete Borrelia burgdorferi during a unique point in its natural infection cycle, which alternates between ticks and small mammals...
  24. ncbi Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease
    M S Klempner
    New England Medical Center and Tufts University School of Medicine, Boston, MA, USA
    N Engl J Med 345:85-92. 2001
    It is controversial whether prolonged antibiotic treatment is effective for patients in whom symptoms persist after the recommended antibiotic treatment for acute Lyme disease.
  25. pmc Analysis of the RpoS regulon in Borrelia burgdorferi in response to mammalian host signals provides insight into RpoS function during the enzootic cycle
    Melissa J Caimano
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Mol Microbiol 65:1193-217. 2007
    ....
  26. ncbi Climate change and the potential for range expansion of the Lyme disease vector Ixodes scapularis in Canada
    N H Ogden
    Groupe de Recherche en Epidémiologie des Zoonoses et Santé Publique, Faculte de Medecine Veterinaire, Universite de Montreal, Que, Canada
    Int J Parasitol 36:63-70. 2006
    ..Seasonal tick activity under climate change scenarios was consistent with maintenance of endemic cycles of the Lyme disease agent in newly established tick populations. The geographic range of I...
  27. pmc BosR (BB0647) governs virulence expression in Borrelia burgdorferi
    Zhiming Ouyang
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Microbiol 74:1331-43. 2009
    Summary Borrelia burgdorferi (Bb), the Lyme disease spirochaete, encodes a potential ferric uptake regulator (Fur) homologue, BosR (BB0647)...
  28. ncbi Performance of a commercially available in-clinic ELISA for the detection of antibodies against Anaplasma phagocytophilum, Ehrlichia canis, and Borrelia burgdorferi and Dirofilaria immitis antigen in dogs
    Ramaswamy Chandrashekar
    Immunoassay R and D, IDEXX Laboratories, 1 IDEXX Dr, Westbrook, ME 04092, USA
    Am J Vet Res 71:1443-50. 2010
    ..To evaluate the sensitivity and specificity of a commercially available in-clinic ELISA for detection of heartworm infection and tick-borne diseases in dogs...
  29. pmc Epidemic spread of Lyme borreliosis, northeastern United States
    Klára Hanincová
    Yale University, New Haven, Connecticut, USA
    Emerg Infect Dis 12:604-11. 2006
    ..burgdorferi is a generalist microparasite and conclude that efficient cross-species transmission of B. burgdorferi is a key feature that has allowed the rapid spread of Lyme borreliosis across the northeastern United States...
  30. pmc The hybrid histidine kinase Hk1 is part of a two-component system that is essential for survival of Borrelia burgdorferi in feeding Ixodes scapularis ticks
    Melissa J Caimano
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030 3715, USA
    Infect Immun 79:3117-30. 2011
    ..In contrast to the Rrp2/RpoN/RpoS pathway, which is active only within feeding nymphs, the Hk1/Rrp1 TCS is essential for survival during both larval and nymphal blood meals...
  31. pmc Borrelia burgdorferi genotype predicts the capacity for hematogenous dissemination during early Lyme disease
    Gary P Wormser
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    J Infect Dis 198:1358-64. 2008
    b>Lyme disease, the most common tickborne disease in the United States, is caused exclusively by Borrelia burgdorferi sensu stricto in North America. The present study evaluated the genotypes of >400 clinical isolates of B...
  32. pmc Molecular interactions that enable movement of the Lyme disease agent from the tick gut into the hemolymph
    Lili Zhang
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS Pathog 7:e1002079. 2011
    Borrelia burgdorferi, the causative agent of Lyme disease, is transmitted to humans by bite of Ixodes scapularis ticks. The mechanisms by which the bacterium is transmitted from vector to host are poorly understood...
  33. pmc HrpA, a DEAH-box RNA helicase, is involved in global gene regulation in the Lyme disease spirochete
    Aydan Salman-Dilgimen
    Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada
    PLoS ONE 6:e22168. 2011
    ..This finding is particularly timely with the recent growth of the field of RNA regulation of gene expression and the ability of RNA helicases to modulate RNA structure and function...
  34. ncbi Passive surveillance for I. scapularis ticks: enhanced analysis for early detection of emerging Lyme disease risk
    Jules K Koffi
    Centre for Food borne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Saint Hyacinthe, Quebec, Canada J2S 7C6
    J Med Entomol 49:400-9. 2012
    b>Lyme disease (LD) is emerging in Canada because of the northward expansion of the geographic range of the tick vector Ixodes scapularis (Say)...
  35. ncbi Tick-host-pathogen interactions in Lyme borreliosis
    Joppe W R Hovius
    University of Amsterdam, Academic Medical Center, Center for Experimental and Molecular Medicine, 1105 AZ Amsterdam, The Netherlands
    Trends Parasitol 23:434-8. 2007
    ..Moreover, we discuss how such vector molecules could be used to develop vector-antigen-based vaccines to prevent the transmission of B. burgdorferi and, potentially, other arthropod-borne microbes...
  36. pmc BosR (BB0647) controls the RpoN-RpoS regulatory pathway and virulence expression in Borrelia burgdorferi by a novel DNA-binding mechanism
    Zhiming Ouyang
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS Pathog 7:e1001272. 2011
    In Borrelia burgdorferi (Bb), the Lyme disease spirochete, the alternative σ factor σ⁵⁴ (RpoN) directly activates transcription of another alternative σ factor, σ(S) (RpoS) which, in turn, controls the expression of virulence-..
  37. pmc Geographic uniformity of the Lyme disease spirochete (Borrelia burgdorferi) and its shared history with tick vector (Ixodes scapularis) in the Northeastern United States
    Wei Gang Qiu
    Department of Ecology and Evolution, State University of New York, Stony Brook, New York 11794 5245, USA
    Genetics 160:833-49. 2002
    Over 80% of reported cases of Lyme disease in the United States occur in coastal regions of northeastern and mid-Atlantic states...
  38. pmc Relationship between immunity to Borrelia burgdorferi outer-surface protein A (OspA) and Lyme arthritis
    Allen C Steere
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Clin Infect Dis 52:s259-65. 2011
    ..Thus, a vaccine-induced immune response to OspA does not replicate the sequence of events needed in the natural infection to induce antibiotic-refractory Lyme arthritis...
  39. ncbi Biodiversity and disease: a synthesis of ecological perspectives on Lyme disease transmission
    Chelsea L Wood
    Department of Biology, Stanford University, Stanford, CA 94305, USA
    Trends Ecol Evol 28:239-47. 2013
    Recent reviews have argued that disease control is among the ecosystem services yielded by biodiversity. Lyme disease (LD) is commonly cited as the best example of the 'diluting' effect of biodiversity on disease transmission, but many ..
  40. pmc Cholesterol lipids of Borrelia burgdorferi form lipid rafts and are required for the bactericidal activity of a complement-independent antibody
    Timothy J LaRocca
    Department of Molecular Genetics and Microbiology, and Center for Infectious Diseases, Stony Brook University, Stony Brook, NY 11794, USA
    Cell Host Microbe 8:331-42. 2010
    Borrelia burgdorferi, the agent of Lyme disease, is unusual as it contains free cholesterol and cholesterol glycolipids...
  41. ncbi Pangloss revisited: a critique of the dilution effect and the biodiversity-buffers-disease paradigm
    S E Randolph
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Parasitology 139:847-63. 2012
    ..We warn against raising a straw man, an untenable argument easily dismantled and dismissed. The intrinsic value of protecting biodiversity and ecosystem function outweighs this questionable utilitarian justification...
  42. ncbi Lyme borreliosis: clinical case definitions for diagnosis and management in Europe
    G Stanek
    Medical University of Vienna, Department of Hygiene and Applied Immunology, Vienna, Austria
    Clin Microbiol Infect 17:69-79. 2011
    ..These new case definitions for European Lyme borreliosis emphasise recognition of clinical manifestations supported by relevant laboratory criteria and may be used in a clinical setting and also for epidemiological investigations...
  43. pmc Role of the surface lipoprotein BBA07 in the enzootic cycle of Borrelia burgdorferi
    Haijun Xu
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Infect Immun 78:2910-8. 2010
    Borrelia burgdorferi, the Lyme disease pathogen, dramatically alters its protein profile when it is transmitted between ticks and mammals...
  44. pmc Borrelia burgdorferi small lipoprotein Lp6.6 is a member of multiple protein complexes in the outer membrane and facilitates pathogen transmission from ticks to mice
    Kamoltip Promnares
    Department of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    Mol Microbiol 74:112-25. 2009
    ..burgdorferi persistence and transmission through a complex enzootic cycle...
  45. pmc Active and passive surveillance and phylogenetic analysis of Borrelia burgdorferi elucidate the process of Lyme disease risk emergence in Canada
    Nicholas H Ogden
    Centre for Food borne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Saint Hyacinthe, Quebec, Canada
    Environ Health Perspect 118:909-14. 2010
    Northward expansion of the tick Ixodes scapularis is driving Lyme disease (LD) emergence in Canada. Information on mechanisms involved is needed to enhance surveillance and identify where LD risk is emerging.
  46. pmc Updates on Borrelia burgdorferi sensu lato complex with respect to public health
    Nataliia Rudenko
    Biology Centre AS CR v v i AS CR, Institute of Parasitology, Branisovska 31, 37005 Ceske Budejovice, Czech Republic
    Ticks Tick Borne Dis 2:123-8. 2011
    ..Recently, the definition of the disease has also changed. What was not considered Lyme borreliosis before might be now...
  47. pmc An ecological approach to preventing human infection: vaccinating wild mouse reservoirs intervenes in the Lyme disease cycle
    Jean I Tsao
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 101:18159-64. 2004
    ..Efforts to reduce disease incidence usually rely on vector control or immunization of humans. Lyme disease, for which no human vaccine is currently available, is a commonly reported vector-borne disease in North ..
  48. pmc Genetic exchange and plasmid transfers in Borrelia burgdorferi sensu stricto revealed by three-way genome comparisons and multilocus sequence typing
    Wei Gang Qiu
    Department of Biological Sciences, Hunter College of the City University of New York, 695 Park Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:14150-5. 2004
    ..coverage) of the genomes of strains JD1 and N40 of Borrelia burgdorferi sensu stricto, the causative agent of Lyme disease, and we compared the predicted genes from the two genomes with those from the previously sequenced B31 genome...
  49. ncbi Inactivation of the fibronectin-binding adhesin gene bbk32 significantly attenuates the infectivity potential of Borrelia burgdorferi
    J Seshu
    Department of Microbial and Molecular Pathogenesis, Texas A and M University Health Science Center, 407 Reynolds Medical Building, College Station, 77843, USA
    Mol Microbiol 59:1591-601. 2006
    Borrelia burgdorferi, the aetiological agent of Lyme disease, utilizes multiple adhesins to interact with both the arthropod vector and mammalian hosts it colonizes...
  50. ncbi The role of VlsE antigenic variation in the Lyme disease spirochete: persistence through a mechanism that differs from other pathogens
    Troy Bankhead
    Department of Biochemistry, University of Calgary, Calgary, Alberta T2N 4 N1, Canada
    Mol Microbiol 65:1547-58. 2007
    The linear plasmid, lp28-1, is required for persistent infection by the Lyme disease spirochete, Borrelia burgdorferi. This plasmid contains the vls antigenic variation locus, which has long been thought to be important for immune evasion...
  51. ncbi Transcriptional interplay among the regulators Rrp2, RpoN and RpoS in Borrelia burgdorferi
    Zhiming Ouyang
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Microbiology 154:2641-58. 2008
    ..Although several known B. burgdorferi virulence determinants were regulated by the RpoN-RpoS pathway, a defined function has yet to be ascribed to most of the genes substantially regulated by Rrp2, RpoN and RpoS...
  52. pmc A new Borrelia species defined by multilocus sequence analysis of housekeeping genes
    Gabriele Margos
    Department of Biology and Biochemistry, University of Bath, 3 South, Claverton Down, Bath BA2 7AY, United Kingdom
    Appl Environ Microbiol 75:5410-6. 2009
    ..We suggest that OspA serotype 4 strains be raised to species status and named Borrelia bavariensis sp. nov. The rooted phylogenetic trees provide novel insights into the evolutionary history of LB spirochetes...
  53. pmc Climate, deer, rodents, and acorns as determinants of variation in lyme-disease risk
    Richard S Ostfeld
    Institute of Ecosystem Studies, Millbrook, New York, USA
    PLoS Biol 4:e145. 2006
    ..scapularis ticks) over 13 y on several field plots within eastern deciduous forests in the epicenter of US Lyme disease (Dutchess County, New York)...
  54. pmc Deer, predators, and the emergence of Lyme disease
    Taal Levi
    Department of Environmental Studies, Center for Integrated Spatial Research, University of California, Santa Cruz, CA 95064, USA
    Proc Natl Acad Sci U S A 109:10942-7. 2012
    b>Lyme disease is the most prevalent vector-borne disease in North America, and both the annual incidence and geographic range are increasing...
  55. pmc Bioluminescent imaging of Borrelia burgdorferi in vivo demonstrates that the fibronectin-binding protein BBK32 is required for optimal infectivity
    Jenny A Hyde
    Department of Microbial and Molecular Pathogenesis, Texas A and M Health Science Center, Bryan, TX 77807, USA
    Mol Microbiol 82:99-113. 2011
    The aetiological agent of Lyme disease, Borrelia burgdorferi, is transmitted via infected Ixodes spp. ticks. Infection, if untreated, results in dissemination to multiple tissues and significant morbidity...
  56. ncbi Comparison of erythema migrans caused by Borrelia burgdorferi and Borrelia garinii
    Franc Strle
    Department of Infectious Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia
    Vector Borne Zoonotic Dis 11:1253-8. 2011
    ..A comparison of patients with erythema migrans due to Borrelia garinii versus Borrelia burgdorferi has not been reported...
  57. ncbi A new approach to a Lyme disease vaccine
    Ian Livey
    Baxter Innovations GmbH, Biomedical Research Center, Orth an der Donau, Austria
    Clin Infect Dis 52:s266-70. 2011
    ....
  58. ncbi Vaccines against Lyme disease: What happened and what lessons can we learn?
    Gregory A Poland
    Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Infect Dis 52:s253-8. 2011
    This article reviews events that led to the withdrawal of the only vaccine to prevent Lyme disease licensed in the United States...
  59. pmc Tick histamine release factor is critical for Ixodes scapularis engorgement and transmission of the lyme disease agent
    Jianfeng Dai
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    PLoS Pathog 6:e1001205. 2010
    ..These findings suggest that blocking tHRF might offer a viable strategy to complement ongoing efforts to develop vaccines to block tick feeding and transmission of tick-borne pathogens...
  60. ncbi Subjective symptoms after treatment of early Lyme disease
    Dasa Cerar
    Department of Infectious Diseases, University Medical Center Ljubljana, Slovenia
    Am J Med 123:79-86. 2010
    Controversy exists over the significance and even the existence of post-Lyme disease symptoms because of the high rate of similar background symptoms in the general population.
  61. pmc Interaction of the Lyme disease spirochete Borrelia burgdorferi with brain parenchyma elicits inflammatory mediators from glial cells as well as glial and neuronal apoptosis
    Geeta Ramesh
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University, Covington, LA 70433, USA
    Am J Pathol 173:1415-27. 2008
    ..burgdorferi. These results provide proof of concept for our hypothesis that B. burgdorferi produces inflammatory mediators in the central nervous system, accompanied by glial and neuronal apoptosis...
  62. pmc The genome of Borrelia recurrentis, the agent of deadly louse-borne relapsing fever, is a degraded subset of tick-borne Borrelia duttonii
    Magali Lescot
    Structural and Genomic Information Laboratory, CNRS UPR2589, IFR88, Parc Scientifique de Luminy, Marseille, France
    PLoS Genet 4:e1000185. 2008
    ..The correlation between gene loss and increased virulence of B. recurrentis parallels that of Rickettsia prowazekii, with both species being genomic subsets of less-virulent strains...
  63. ncbi Investigations on the mode and dynamics of transmission and infectivity of Borrelia burgdorferi sensu stricto and Borrelia afzelii in Ixodes ricinus ticks
    Mara Crippa
    Institut de Zoologie, University of Neuchatel, Switzerland
    Vector Borne Zoonotic Dis 2:3-9. 2002
    Borrelia burgdorferi sensu lato (sl), the agent of Lyme disease, is transmitted to the host during the blood meal of Ixodes ticks...
  64. ncbi Correcting a public health fiasco: The need for a new vaccine against Lyme disease
    Stanley A Plotkin
    University of Pennsylvania, Doylestown, 18902, USA
    Clin Infect Dis 52:s271-5. 2011
    A vaccine against Lyme disease was licensed in the United States in 1998 but was subsequently removed from the market because of lack of sales...
  65. ncbi Lyme disease and preventive behaviors in residents of Nantucket Island, Massachusetts
    C B Phillips
    Division of Rheumatology, Immunology and Allergy, Robert B Brigham Multipurpose Arthritis and Musculoskeletal Diseases Center, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Prev Med 20:219-24. 2001
    To determine the age-specific prevalence of Lyme disease and whether preventive behaviors on Nantucket Island correlate with Lyme disease, we surveyed island residents.
  66. pmc Antigenic and genetic heterogeneity of Borrelia burgdorferi populations transmitted by ticks
    J Ohnishi
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 98:670-5. 2001
    ..burgdorferi transmission. Implicit in our model is the concept that tick transmission converts a homogeneous spirochete population into a heterogeneous population that is poised to infect the mammalian host...
  67. pmc Predicting the risk of Lyme disease: habitat suitability for Ixodes scapularis in the north central United States
    Marta Guerra
    College of Veterinary Medicine, University of Illinois, 2001 S Lincoln Avenue MC 002, Urbana, IL 61802, USA
    Emerg Infect Dis 8:289-97. 2002
    ..scapularis is already established. The risk map also shows areas of high probability the tick will become established if introduced. Thus, this risk analysis has both explanatory power and predictive capability...
  68. pmc Biodiversity of Borrelia burgdorferi strains in tissues of Lyme disease patients
    Dustin Brisson
    Biology Department, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e22926. 2011
    ..burgdorferi found in tick populations with that found in skin, blood, synovial fluid or cerebrospinal fluid of Lyme disease patients. The biodiversity of B...
  69. pmc Diagnosis of lyme borreliosis
    Maria E Aguero-Rosenfeld
    Department of Pathology, Division of Infectious Diseases, New York Medical College, Valhalla, NY, USA
    Clin Microbiol Rev 18:484-509. 2005
    ..Evaluation of these assays is currently being done, and there is evidence that certain of these antigens may be broadly cross-reactive with the B. burgdorferi sensu lato species causing LB in Europe...
  70. pmc Lyme disease
    Thomas S Murray
    Department of Pediatric, Yale University, New Haven, CT 06520 8064, USA
    Clin Lab Med 30:311-28. 2010
    b>Lyme disease, caused by the spirochete Borrelia burgdorferi, is the most common vector-borne disease in the United States...
  71. pmc The bba64 gene of Borrelia burgdorferi, the Lyme disease agent, is critical for mammalian infection via tick bite transmission
    Robert D Gilmore
    Bacterial Diseases Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA
    Proc Natl Acad Sci U S A 107:7515-20. 2010
    The spirochetal agent of Lyme disease, Borrelia burgdorferi, is transmitted by bites of Ixodes ticks to mammalian reservoir hosts and humans. The mechanism(s) by which the organism is trafficked from vector to host is poorly understood...
  72. pmc The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirochete
    Jenny A Hyde
    Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M Health Science Center, College Station, TX 77843 1114, USA
    Mol Microbiol 74:1344-55. 2009
    Summary Borrelia burgdorferi, the Lyme disease spirochete, adapts as it moves between the arthropod and mammalian hosts that it infects. We hypothesize that BosR serves as a global regulator in B...
  73. pmc Borrelia burgdorferi population kinetics and selected gene expression at the host-vector interface
    Emir Hodzic
    Center for Comparative Medicine, School of Medicine, University of California at Davis, Davis, California 95616, USA
    Infect Immun 70:3382-8. 2002
    ..Evidence of ospA transcription in skin could be found 1 day after tick attachment but not thereafter...
  74. pmc Hosts as ecological traps for the vector of Lyme disease
    F Keesing
    Department of Biology, Bard College, Annandale, NY 12504, USA
    Proc Biol Sci 276:3911-9. 2009
    ..In this study we tested whether blacklegged ticks, the vectors of Lyme disease, granulocytic anaplasmosis and babesiosis can be regulated by the species of vertebrate hosts on which they ..
  75. pmc Distinct cerebrospinal fluid proteomes differentiate post-treatment lyme disease from chronic fatigue syndrome
    Steven E Schutzer
    Department of Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, United States of America
    PLoS ONE 6:e17287. 2011
    Neurologic Post Treatment Lyme disease (nPTLS) and Chronic Fatigue (CFS) are syndromes of unknown etiology. They share features of fatigue and cognitive dysfunction, making it difficult to differentiate them...
  76. pmc A new animal model for studying Lyme disease spirochetes in a mammalian host-adapted state
    D R Akins
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Clin Invest 101:2240-50. 1998
    There is now substantial evidence that Borrelia burgdorferi, the Lyme disease spirochete, undergoes major alterations in antigenic composition as it cycles between its arthropod and mammalian hosts. In this report, we cultivated B...
  77. pmc Simultaneous detection and genotyping of three genomic groups of Borrelia burgdorferi sensu lato in Dutch Ixodes ricinus ticks by characterization of the amplified intergenic spacer region between 5S and 23S rRNA genes
    S G Rijpkema
    Laboratory of Bacteriology and Antimicrobial Agents, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Clin Microbiol 33:3091-5. 1995
    ..burgdorferi sensu lato in ticks collected in the field. This technique provides new ways to study the association of genomic groups present in ticks and the risk of Lyme borreliosis...
  78. pmc Population genetics, taxonomy, phylogeny and evolution of Borrelia burgdorferi sensu lato
    Gabriele Margos
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Infect Genet Evol 11:1545-63. 2011
    ....
  79. ncbi Prospective study on the incidence of infection by Borrelia burgdorferi sensu lato after a tick bite in a highly endemic area of Switzerland
    Delphine Huegli
    Institut de Biologie, Laboratoire d Eco Epidémiologie, Universite de Neuchatel, 2000 Neuchatel, Switzerland
    Ticks Tick Borne Dis 2:129-36. 2011
    ..9% of nymphs remained attached for more than 24h whereas only 38.3% of female ticks remained attached for more than 24h. We observed that 6.6% and 2.4% of participants bitten by infected and uninfected ticks, respectively, developed EM...
  80. ncbi Vasculitis-like syndrome associated with Borrelia lusitaniae infection
    I Lopes de Carvalho
    Center for Vector and Infectious Diseases Research, Instituto Nacional de Saude Dr Ricardo Jorge, Lisbon, Portugal
    Clin Rheumatol 27:1587-91. 2008
    ..In order to prevent the occurrence of more serious disease manifestations via timely treatment, the analysis by molecular methods may be a useful approach when antibody titres are uninformative...
  81. ncbi Spatial dynamics of lyme disease: a review
    Mary E Killilea
    Cary Institute of Ecosystem Studies, Millbrook, NY 12545 0129, USA
    Ecohealth 5:167-95. 2008
    b>Lyme disease (LD), the most frequently reported vector-borne disease in the United States, requires that humans, infected vector ticks, and infected hosts all occur in close spatial proximity...
  82. pmc Oligopeptide permease A5 modulates vertebrate host-specific adaptation of Borrelia burgdorferi
    B V Subba Raju
    South Texas Center for Emerging Infectious Diseases and Department of Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USA
    Infect Immun 79:3407-20. 2011
    Borrelia burgdorferi, the agent of Lyme disease, undergoes rapid adaptive gene expression in response to signals unique to its arthropod vector or vertebrate hosts...
  83. pmc Interleukin-10 alters effector functions of multiple genes induced by Borrelia burgdorferi in macrophages to regulate Lyme disease inflammation
    Aarti Gautam
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana, USA
    Infect Immun 79:4876-92. 2011
    ..IL-10) modulates inflammatory responses elicited in vitro and in vivo by Borrelia burgdorferi, the Lyme disease spirochete. How IL-10 modulates these inflammatory responses still remains elusive...
  84. ncbi Prevalence and incidence of antibodies to Borrelia burgdorferi and to tick-borne encephalitis virus in agricultural and forestry workers from Tuscany, Italy
    P Tomao
    Department of Occupational Medicine, Istituto Superiore per la Prevenzione e la Sicurezza del Lavoro, Via Fontana Candida 1, 00040, Monteporzio Catone Rome, Italy
    Eur J Clin Microbiol Infect Dis 24:457-63. 2005
    ..03% vs. 3.56% in the confirmatory test). No seropositivity was observed for TBE virus. Eighteen of 176 subjects who underwent a second blood test developed specific antibodies against Borrelia burgdorferi within 1 year...
  85. ncbi Late and chronic Lyme disease
    Sam T Donta
    Divisions of Infectious Disease and BioMolecular Medicine, Lyme Disease Unit, Boston University Medical Center, Boston, Massachusetts, USA
    Med Clin North Am 86:341-9, vii. 2002
    This article reviews the late and chronic manifestations of Lyme disease. Special attention is given to the chronic manifestations of the disease, detailing its pathogenesis, clinical spectrum, and laboratory criteria for the diagnosis...
  86. pmc Anti-Borrelia burgdorferi antibody profile in post-Lyme disease syndrome
    Abhishek Chandra
    Department of Neurology and Neuroscience, Weill Cornell Medical College, Cornell University, New York, New York, USA
    Clin Vaccine Immunol 18:767-71. 2011
    Patients with post-Lyme disease syndrome (PLDS) report persistent symptoms of pain, fatigue, and/or concentration and memory disturbances despite antibiotic treatment for Lyme borreliosis...
  87. ncbi Low risk of developing Borrelia burgdorferi infection in the south-east of Sweden after being bitten by a Borrelia burgdorferi-infected tick
    Linda Fryland
    Division of Clinical Immunology, Department of Clinical and Experimental Medicine, Linkoping University, S 581 85 Linkoping, Sweden
    Int J Infect Dis 15:e174-81. 2011
    ..In the current study, we investigated the prevalence of Bb in ticks that had bitten humans and the risk of developing LB from Bb-infected ticks...
  88. pmc Genetic diversity of Borrelia burgdorferi and detection of B. bissettii-like DNA in serum of north-coastal California residents
    Yvette A Girard
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California, USA
    J Clin Microbiol 49:945-54. 2011
    ..Further molecular testing of sera from residents in areas where LB is endemic is warranted to enhance our understanding of the geographic distribution and frequency of occurrence of B. bissettii-like infections...
  89. pmc Borrelia burgdorferi RevA antigen binds host fibronectin
    Catherine A Brissette
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Chandler Medical Center MN469, Lexington, Kentucky 40536 0298, USA
    Infect Immun 77:2802-12. 2009
    Borrelia burgdorferi, the Lyme disease-causing spirochete, can persistently infect its vertebrate hosts for years. B...
  90. pmc CsrA modulates levels of lipoproteins and key regulators of gene expression critical for pathogenic mechanisms of Borrelia burgdorferi
    S L Rajasekhar Karna
    South Texas Center for Emerging Infectious Diseases and Department of Biology, The University of Texas at San Antonio, San Antonio, Texas 78249, USA
    Infect Immun 79:732-44. 2011
    ..The further characterization of molecular basis of regulation mediated by CsrA(Bb) will provide significant insights into the pathophysiology of B. burgdorferi...
  91. ncbi Lyme disease: a review
    Adriana R Marques
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11 N234, Bethesda, MD 20892, USA
    Curr Allergy Asthma Rep 10:13-20. 2010
    b>Lyme disease is the most common vector-borne illness in the United States and is also endemic in Europe and Asia. It is caused by the spirochete Borrelia burgdorferi and transmitted by the bite of the Ixodes (deer) tick...
  92. ncbi Use of tick surveys and serosurveys to evaluate pet dogs as a sentinel species for emerging Lyme disease
    Sarah A Hamer
    Department of Fisheries and Wildlife, College of Agricultural and Natural Resources, Michigan State University, East Lansing, MI 48824, USA
    Am J Vet Res 70:49-56. 2009
    To evaluate dogs as a sentinel species for emergence of Lyme disease in a region undergoing invasion by Ixodes scapularis.
  93. pmc Functional analysis of the Borrelia burgdorferi bba64 gene product in murine infection via tick infestation
    Toni G Patton
    Microbiology and Pathogenesis Activity, Division of Vector Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA
    PLoS ONE 6:e19536. 2011
    ..Collectively, the results of this study indicate that BBA64 functions at the salivary gland-to-host delivery interface of vector transmission and is not involved in resistance to MyD88-mediated innate immunity...
  94. ncbi Cardiac involvement in non-human primates infected with the Lyme disease spirochete Borrelia burgdorferi
    Diego Cadavid
    Department of Neurology and Neuroscience, UMDNJ New Jersey Medical School, Newark, NJ, USA
    Lab Invest 84:1439-50. 2004
    To investigate cardiac involvement in the non-human primate (NHP) model of Lyme disease, we inoculated 39 adult Macaca mulatta with Borrelia burgdorferi sensu stricto strains N40 (BbN40) by needle (N=22, 14 immunocompetent (IC), seven ..
  95. ncbi Counterpoint: long-term antibiotic therapy improves persistent symptoms associated with lyme disease
    Raphael B Stricker
    International Lyme and Associated Diseases Society, Bethesda, MD, USA
    Clin Infect Dis 45:149-57. 2007
    Controversy exists regarding the diagnosis and treatment of Lyme disease. Patients with persistent symptoms after standard (2-4-week) antibiotic therapy for this tickborne illness have been denied further antibiotic treatment as a result ..
  96. pmc Borrelia burgdorferi lacking DbpBA exhibits an early survival defect during experimental infection
    Eric H Weening
    Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M Health Science Center, College Station, TX 77843, USA
    Infect Immun 76:5694-705. 2008
    ..Several Borrelia burgdorferi genes induced under mammalian host conditions have been purported to be important in Lyme disease pathogenesis based on their binding to host structures...
  97. pmc Determinants of the geographic distribution of Puumala virus and Lyme borreliosis infections in Belgium
    Catherine Linard
    Department of Geography, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Int J Health Geogr 6:15. 2007
    ..Municipalities were taken as units of analysis...
  98. pmc Human integrin α(3)β(1) regulates TLR2 recognition of lipopeptides from endosomal compartments
    Meghan L Marre
    Graduate Program in Immunology, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, USA
    PLoS ONE 5:e12871. 2010
    ..Adaptors and co-receptors that mediate this process, as well as the mechanisms by which these adaptors and co-receptors function, are still being discovered...
  99. pmc T-cell-independent responses to Borrelia burgdorferi are critical for protective immunity and resolution of lyme disease
    M D McKisic
    Center for Comparative Medicine, University of California, Davis, California 95616, USA
    Infect Immun 68:5190-7. 2000
    ..These data demonstrate that B-cell activation during a T-cell-independent response may be critical for resolution of arthritis and carditis and that protective antibodies are generated during this response...
  100. pmc Role of acetyl-phosphate in activation of the Rrp2-RpoN-RpoS pathway in Borrelia burgdorferi
    Haijun Xu
    Institute of Insect Science, Zhejiang University, Hangzhou, China
    PLoS Pathog 6:e1001104. 2010
    Borrelia burgdorferi, the Lyme disease spirochete, dramatically alters its transcriptome and proteome as it cycles between the arthropod vector and mammalian host...
  101. ncbi The utility of "Google Trends" for epidemiological research: Lyme disease as an example
    Ari Seifter
    Lyme Disease Research Foundation of Maryland, 10755 Falls Road, Lutherville, MD 21093, USA
    Geospat Health 4:135-7. 2010
    ..We report briefly on exploring this resource using Lyme disease as an example because it has well-described seasonal and geographic patterns...

Research Grants75

  1. A unique approach to identify markers for congenital syphilis and neurosyphilis
    Nikhat Parveen; Fiscal Year: 2010
    ..T. pallidum is closely related to Borrelia burgdorferi, which causes Lyme disease. Both of these spirochetes are structurally and physiologically similar organisms and share several homologous ..
  2. Hospital - Based Surveillance of Acute Febrile Illness in Western Ghat Region of
    ARUNKUMAR GOVINDAKARNAVAR; Fiscal Year: 2013
    ..that of Kyasanur Forest Disease (KFD), Leptospirosis, Rickettsial disease such as Scrub Typhus, Dengue and Lyme disease in the Western Ghat region of India...
  3. Biophysics of the morphology and motility of Borrelia burgdorferi in diverse envi
    Charles W Wolgemuth; Fiscal Year: 2013
    ..If untreated, Lyme disease can lead to a wide array of complications typically involving the heart, joints, or nervous system...
  4. Tick-Mammal Interface of Human Granulocytic Anaplasmosis
    ULRIKE GERTRUD MUNDERLOH; Fiscal Year: 2013
    ..HEALTH RELEVANCE: Human granulocytotropic anaplasmosis (HGA) is an emerging tick-borne disease that, like Lyme disease, is transmitted by black-legged ticks (deer ticks) primarily in the Northeast and upper Midwest of the US, but ..
  5. A common denominator of pathogenesis;a rare opportunity for novel therapeutic de
    DOUGLAS ALAN MITCHELL; Fiscal Year: 2011
    ..the potential role of the SLS-like toxin in an additional organism, Borrelia burgdorferi (Bb), which causes Lyme disease. Although widely known, the Bb molecular mechanism of pathogenesis is inadequately defined...
  6. Tick Midgut Proteins Critical for Borrelia Transmission
    Sukanya Narasimhan; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Ixodes scapularis ticks transmit Borrelia burgdorferi (agent of Lyme disease), Anaplasma phagocytophilum (agent of human granulocytic ehrlichiosis) and Babesia microti (agent of human babesiosis) ..
  7. GAMMA DELTA T CELLS IN LYME ARTHRITIS
    Ralph C Budd; Fiscal Year: 2011
    b>Lyme Disease is the most common vector-borne illness in the U.S. and is caused by transmission of the spirochete, Borrelia burgdorferi, via the tick Ixodes scapularis...
  8. Phagosomal Signals Shape Inflammatory Responses to Borrelia Burgdorferi
    Juan C Salazar; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Lyme disease (LD) is a tick-borne, multi-system, infectious disorder caused by the extracellular spirochetal bacterium Borrelia burgdorferi (Bb)...
  9. Tick feeding regulation by orthologous tick saliva serine protease inhibitors
    Albert Mulenga; Fiscal Year: 2013
    ..deer (Odocoileus virginianus) in the emergence of major human tick borne diseases (TBD) in the United States, Lyme disease, human anaplasmosis, babesiosis and ehrlichiosis and the southern tick-associated rash illness (STARI) has been ..
  10. Development of a multivalent vaccine for mouse reservoirs of deer tick pathogens
    Linden T Hu; Fiscal Year: 2010
    Ixodes ticks serve as the vector for 3 human infections in the U.S.-- Lyme disease, Babesiosis and human granulocytic ehrlichiosis. The incidence of all three diseases has been increasing over the last decade...
  11. Lyme neuroborreliosis pathogenesis in the rhesus monkey
    MARIO TOMAS PHILIPP; Fiscal Year: 2013
    ..plan to address these goals with experiments in vitro, ex vivo, and in vivo, using the rhesus monkey model of Lyme disease. PUBLIC HEALTH RELEVANCE: Lyme disease, the most frequently reported arthropod-borne disease in the United ..
  12. Structural Immunology of CD1 and CD1-TCR Complexes
    Dirk M Zajonc; Fiscal Year: 2013
    ..and can respond to glycolipids from infectious organisms, such as Borrelia burgdorferi the causative agent of Lyme disease and self-lipids, during the course of autoimmune disease such as Multiple sclerosis...
  13. MALDI-TOF/TOF MS TO SUPPORT BIOMEDICAL RESEARCH
    Catherine E Costello; Fiscal Year: 2012
    ..in prion and systemic amyloid diseases (Harris, Seldin) protective components in human milk (Newburg), Lyme disease and rheumatoid arthritis (Steere), other infectious organisms (Samuelson and Robbins), and wound healing in the ..
  14. Virulence Determinants of Borrelia burgdorferi
    Steven J Norris; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Borrelia burgdorferi is the causative agent of Lyme disease in North America and is transmitted by ticks of the genus Ixodes...
  15. Subverted host cell signaling by AnkA in Anaplasma phagocytophilum infection
    Jacob W IJdo; Fiscal Year: 2012
    ..In the Unites States it is the second most common tick-associated infection, only surpassed by Lyme disease. Although neutrophils are very efficient in killing bacteria, A...
  16. RpoS Regulation of Borrelia burgdorferi Genes in vivo
    Justin D Radolf; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lyme disease (LD), caused by the spirochete Borrelia burgdorferi (Bb), is the most common arthropod-borne infection in the United States...
  17. RpoS-mediated virulence regulation in Borrelia burgdorferi
    JON SCOTT BLEVINS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): During its natural lifecycle, the Lyme disease spirochete, Borrelia burgdorferi, occupies both an arthropod tick vector and a mammalian host...
  18. OspC regulation and pathogenic strategy of Borrelia burgdorferi
    Fang Ting Liang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lyme disease caused by the spirochete Borrelia burgdorferi is the most common vector-borne illness in North America...
  19. Humoral responses to Lyme Borreliosis: A mouse model
    Nicole Baumgarth; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Lyme Disease is a chronic disabling disease resulting from a tick-bite...
  20. Diagnostic Assays for early Lyme Borreliosis using in-vivo expressed antigens
    Michel Ledizet; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Lyme disease, due to infection with the Ixodes tick-transmitted spirochete Borrelia burgdorferi, is the most common vector-borne disease in the United States, with over 38,000 confirmed and probable ..
  21. VIRULENCE-ASSOCIATED PROTEINS IN LYME DISEASE
    Steven J Norris; Fiscal Year: 2013
    ..Borrelia burgdorferi and related organisms cause Lyme disease, a multistage, systemic infection that is transmitted by Ixodes ticks and has dermatologic, neurologic, ..
  22. BORRELIA BURGDORFERI MITOGEN IN DEVELOPMENT OF ARTHRITIS
    Janis J Weis; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lyme Disease is caused by infection with the tick-borne spirochete Borrelia burgdorferi, and results in arthritis in up to 60% of infected individual...
  23. Determinants of Borrelia Diversity and Population Structure
    ELISABETH BAUM; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Lyme disease is the most common vector-borne disease in the United States, and its incidence and geographic distribution are expected to increase with further climate change...
  24. Outer membrane proteins of Borrelia burgdorferi
    Darrin R Akins; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lyme disease is a major public health problem worldwide and is the most common arthropod- borne infection in the United States...
  25. 2009 Spirochetes, Biology of
    David A Haake; Fiscal Year: 2010
    ..Many spirochetes are pathogens, and they cause a variety of diseases, including syphilis, Lyme disease, relapsing fever, leptospirosis, periodontal disease, digital dermatitis of cattle, and swine and human ..
  26. PEROMYSCUS LABORATORY MODELS FOR BIOMEDICAL RESEARCH
    Gabor Szalai; Fiscal Year: 2013
    ..The causative agent of Lyme disease is also harbored in Peromyscus and nearly 15,000 cases occur annually...
  27. Gene Expression Biomarkers for Diagnosis of Lyme Disease
    IRA S SCHWARTZ; Fiscal Year: 2012
    DESCRIPTION (provided by the applicant): Lyme disease is the most frequently reported tick-borne infectious disease in the United States and both its incidence and range are increasing...
  28. Delineation of Borrelia burgdorferi motility and chemotaxis in the development of
    MD A MOTALEB; Fiscal Year: 2013
    ..provided by applicant): Delineation of Borrelia burgdorferi motility and chemotaxis in the development of Lyme disease Lyme disease is caused by the spirochetal bacteria Borrelia burgdorferi (Bb), which is transmitted to humans by ..
  29. A New Cytokine-Based Immunoassay for the Diagnosis of Lyme Disease
    Linda K Bockenstedt; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lyme disease (LD), caused by the Ixodes tick-borne spirochete Borrelia burgdorferi (Bb), is the most common vector-borne disease in the United States...
  30. Virulence Determinants of Borrelia burgdorferi
    Steven J Norris; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Borrelia burgdorferi is the causative agent of Lyme disease in North America and is transmitted by ticks of the genus Ixodes...
  31. The RpoN-RpoS regulatory pathway in Borrelia burgdorferi
    Michael V Norgard; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Borrelia burgdorferi (Bb), the Lyme disease spirochete, undergoes dramatic adaptive changes as it cycles in nature between its diverse tick and mammalian hosts...
  32. Babesiosis Emergence in the United States
    MARIA ANA DIUK-WASSER; Fiscal Year: 2013
    ..zoonosis in the United States caused by the protozoan Babesia microti and transmitted by Ixodes scapularis, the Lyme disease vector...
  33. Assessing the Cumulative Climate-Related Health Risks in the Eastern U.S.
    Yang Liu; Fiscal Year: 2011
    ..5) and distal (Lyme disease vectors as the prototype)...
  34. Comprehensive Analysis of Borrelia burgdorferi Adhesins
    John M Leong; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Borrelia burgdorferi, a causative agent of Lyme disease, establishes persistent infection that can affect the joints, heart, skin, and nervous system...
  35. Genetic Mechanisms in Borrelia burgdorferi Pathogenesis
    Jonathan T Skare; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Borrelia burgdorferi, the etiologic agent of Lyme disease, is the most common arthropod- borne infectious agent in the United States, and contributes to a significant amount of morbidity in ..
  36. Characterization of C02 Sensing and Regulatory Response in Borrelia burgdorferi
    Jennifer Hyde; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): It is well established that Borrelia burgdorferi, the etiologic agent of Lyme disease, adapts to distinct environments as it moves between an arthropod vector and mammalian hosts. B...
  37. BORRELIA BURGDORFERI MITOGEN IN DEVELOPMENT OF ARTHRITIS
    Janis J Weis; Fiscal Year: 2012
    ..Project Narrative: Two distinct types of responses have been identified in mice infected with the agent of Lyme disease, Borrelia burgdorferi...
  38. T cell responses to CD1-restricted lipids in tuberculosis
    DAVID BRANCH MOODY; Fiscal Year: 2013
    ..results would also inform understanding of the pathogenesis of related T cell-mediated diseases like sepsis, Lyme disease, allergic asthma and atherosclerosis...
  39. Use of massively parallel sequencing for identification of B. burgdorferi virulen
    Tao Lin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Borrelia burgdorferi, the causative agent of Lyme disease, is a tick-borne bacterial pathogen that is able to escape host immune defenses to establish chronic infections in the skin, heart, joints, ..
  40. RpoS Regulation of Borrelia burgdorferi Genes in vivo
    Justin D Radolf; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Lyme disease (LD), caused by the spirochete Borrelia burgdorferi (Bb), is the most common arthropod-borne infection in the United States...
  41. MOLECULAR GENETICS OF LYME ARTHRITIS SUSCEPTIBILITY
    Janis J Weis; Fiscal Year: 2013
    ..burgdorferi signaling in macrophages. ..
  42. An Intracellular Niche for Borrelia burgdorferi
    Jonathan T Skare; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lyme disease, caused by the spirochetal bacterium Borrelia burgdorferi, is the leading arthropodborne infection in the United States and causes significant morbidity in endemic areas. If untreated B...
  43. Defining Microbial and Host Factors in Innate Immune Responses in Lyme Arthritis
    Klemen Strle; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lyme disease has reached epidemic proportions and continues to spread in certain locations in the northeastern U.S. This region is affected by an especially inflammatory B...
  44. The Structure and Function of the Bacterial Chemosome
    Brian R Crane; Fiscal Year: 2013
    ..Importantly, many human pathogens such Vibrio cholerae, Helicobacter pylori, and Borrelia burgdorferi (Lyme disease) rely on chemotaxis to establish infection...
  45. A Lyme disease vaccine using newly identified in-vivo expressed antigens
    Michel Ledizet; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lyme disease is the most common arthropod-borne disease in the United States, with over 38,000 confirmed and probable cases reported in 2009...
  46. Immunologic mechanisms in post-Lyme disease syndrome
    Armin Alaedini; Fiscal Year: 2011
    b>Lyme disease is a multisystem infection, caused by bacteria of the Borrelia burgdorferi species complex and transmitted by Ixodes ticks...
  47. Xenodiagnosis of Lyme Disease
    Linden T Hu; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Lyme disease is the most common vector borne disease in the United States...
  48. Borrelia burgdorferi tick phase genes and Lyme disease pathogenesis
    IRA S SCHWARTZ; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lyme disease, the most commonly reported arthropod-borne disease in the United States, is caused by infection with the spirochete, Borrelia burgdorferi. Maintenance of B...
  49. Analysis of the Borrelia burgdorferi Integrin Ligand P66
    Jenifer L Coburn; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lyme disease spirochetes disseminate from the site of inoculation via tick bite, and are able to persist despite the host immune response, indicating that interactions with mammalian cells occur ..
  50. Cellular processing and role of a surface antigen in borrelial pathogenesis
    Xiuli Yang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lyme disease, a prevalent arthropod-borne disease, results from infection with the bacterial pathogen Borrelia burgdorferi...
  51. Critical Roles for Iron and Copper Detoxification in Borrelia burgdorferi
    Xin Li; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lyme disease is the most common vector-borne disease in the United States...
  52. The Role of BBI36/38 in Lyme Disease Pathogenesis
    Andrew J Nowalk; Fiscal Year: 2010
    ..b>Lyme disease is the most common vector-borne infection reported in the United States, and has doubled in incidence in the ..
  53. Outer membrane proteins of Borrelia burgdorferi
    Darrin R Akins; Fiscal Year: 2011
    b>Lyme disease is a major public health problem worldwide and is the most common arthropodborne infection in the United States...
  54. BORRELIA BURGDORFERI INTERACTIONS WITH IXODES SCAPULARIS
    Erol Fikrig; Fiscal Year: 2012
    The goal of this proposal is to better understand the intimate relationship between Borrelia burgdorferi, the Lyme disease agent, and one of its major tick vectors, Ixodes scapularis -- in order to develop novel strategies to prevent ..
  55. Development of a Cytokine Release Assay as a Diagnostic Test for Lyme Disease
    PAUL MICHAEL ARNABOLDI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lyme disease is the most common vector borne infectious disease in North America and Europe. It is a progressive disease with a wide array of clinical manifestations...
  56. Phagosomal Signals Shape Inflammatory Responses to B. Burgdorferi
    Juan C Salazar; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lyme disease (LD) is a tick-borne, multi-system, infectious disorder caused by the extracellular spirochetal bacterium Borrelia burgdorferi (Bb)...
  57. Overwintering mortality of nymphal Ixodes scapularis, Lyme disease vector, in a c
    RICHARD S contact OSTFELD; Fiscal Year: 2010
    ..tick (Ixodes scapularis), which vectors the agents of three emerging infectious diseases in North America: Lyme disease, human granulocytic anaplasmosis, and babesiosis...
  58. Borella Gene Products Critical For Natural Infection Cycle
    Utpal Pal; Fiscal Year: 2013
    ..contribute to specific aspects of microbial biology and pathogenesis and also assess their potential utility as Lyme disease vaccines. We have four major goals. First, we will examine how a critical virulence determinant of B...
  59. Ordered Membrane Domain Formation and Function in Pathogenic Bacteria
    Erwin London; Fiscal Year: 2013
    ..Jorge Benach (Stony Brook U.) the co-discoverer of Borrelia burgdorferi as the causative agent of Lyme disease, we found that B...
  60. A serologic assay to measure successful Lyme borreliosis antibiotic therapy
    Michel Ledizet; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Lyme disease, due to infection with the Ixodes tick-transmitted spirochete Borrelia burgdorferi, is the most common vector-borne disease in the United States, with over 20,000 cases reported to the ..
  61. Structural studies of DNA resolvases involved in hairpin telomere maintenance
    Hideki Aihara; Fiscal Year: 2013
    ..and viruses carrying linear chromosomes, including members of the genus Borrelia - the causative agents of Lyme disease and relapsing fever - and the poxviruses...
  62. The RpoN-RpoS regulatory pathway in Borrelia burgdorferi
    MICHAEL NORGARD; Fiscal Year: 2009
    Abstract: Borrelia burgdorferi (Bb), the Lyme disease spirochete, undergoes dramatic adaptive changes as it cycles in nature between its diverse tick and mammalian hosts...
  63. Coinfection of Tick-borne Diseases in Areas of Wisconsin
    DIANE CAPORALE; Fiscal Year: 2001
    DESCRIPTION (provided by the applicant): Close to 400 human cases of Lyme disease and several --cases of Babesiosis and Human Granulocytic Ehrlichiosis (HGE) are reported in the State of Wisconsin each year...
  64. Protective Role of Interleukin 10 in Neuroborreliosis
    Diego Cadavid; Fiscal Year: 2009
    ..infections of humans causing CNS infection and neurological disease include syphilis, leptospirosis, Lyme disease and relapsing fever (RF)...
  65. The role of Borrelia burgdorferi chemotoxis in the pathogenesis of Lyme disease
    Md Motaleb; Fiscal Year: 2009
    b>Lyme disease is the most prevalent arthropod borne infection in the United States. The disease is caused by the spirochete Borrelia burgdorferi, which is transmitted to humans via infected Ixodes ticks...
  66. NOVEL ANTIGENS FOR THE SERODIAGNOSIS OF HUMAN BABESIOSIS
    Raymond Houghton; Fiscal Year: 2001
    Increase surveillance of tick-borne infections has shown that many individuals infected with Lyme disease have co-infections with Babesia microti (agent of human babesiosis) and Ehrlichia, both of which are potentially fatal in ..
  67. Chronic Lyme Arthritis: Is this Autoimmunity?
    Brigitte Huber; Fiscal Year: 2005
    b>Lyme disease is a multifaceted illness, initiated upon infection with the spirochete Borrelia burgdorferi (Bb)...
  68. PREVENTION OF LYME DISEASE--RANDOMIZED CLINICAL TRIAL
    Eugene Shapiro; Fiscal Year: 1991
    b>Lyme disease (Lyme borreliosis) is a multisystem illness that is caused by the spirochete Borrelia burgdorferi. It is being recognized with increas- ing frequency and in a widening geographic distribution...
  69. HEALTH BURDERN OF COINFECTING DEER ASSOCIATED ZOONOSES
    Peter Krause; Fiscal Year: 2001
    Although public attention has focused largely on Lyme disease, an array of spirochetal, protozoan, viral and rickettsial pathogens concurrently infect residents of sites in the eastern US in which deer are abundant...
  70. DbpA/B proteins of Borrelia burgdorferi & Lyme arthritis
    Nikhat Parveen; Fiscal Year: 2005
    b>Lyme disease presents a unique clinical system to study cellular and molecular mecahnisms responsible for chronic inflammatory diseases...
  71. Pathogenesis of Borrelia burgdorferi induced arthritis
    Linden Hu; Fiscal Year: 2006
    DESCRIPTION (provided by the applicant): Arthritis is a late manifestation of Lyme disease. Allowed to progress untreated, Lyme arthritis can result in a severe, erosive arthritis...
  72. LYME DISEASE--DEVELOPMENT OF SKIN LESIONS AND ARTHRITIS
    GAIL HABICHT; Fiscal Year: 1993
    b>Lyme disease is caused by infection with a spirochete, Borrelia burgdorferi which is transmitted by the bite of Ixodes ticks...
  73. Prevention of Lyme Disease in Connecticut
    Matthew Cartter; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): The emergence of Lyme disease (LD) as a public health problem in Connecticut over the last 28 years is due to the increased risk of tick bites among persons who live increasingly in suburban and rural ..
  74. Biodiversity, Habitat Fragmentation, & Lyme Disease Risk
    RICHARD OSTFELD; Fiscal Year: 2006
    ..and the ecological landscapes in which vectors, pathogens, hosts, and humans interact to affect exposure to Lyme disease. We focus on Lyme disease because of its high incidence, widespread distribution, large body of ecological and ..
  75. HOST CELL INTERACTIONS BY PATHOGENIC BORRELIAE
    JOHN LEONG; Fiscal Year: 2000
    Borrelia burgdorferi is the causative agent of Lyme disease, and B. hermsii and B. turicatae are causative agents of tick-borne relapsing fever...