lyme disease

Summary

Summary: An infectious disease caused by a spirochete, BORRELIA BURGDORFERI, which is transmitted chiefly by Ixodes dammini (see IXODES) and pacificus ticks in the United States and Ixodes ricinis (see IXODES) in Europe. It is a disease with early and late cutaneous manifestations plus involvement of the nervous system, heart, eye, and joints in variable combinations. The disease was formerly known as Lyme arthritis and first discovered at Old Lyme, Connecticut.

Top Publications

  1. ncbi The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America
    Gary P Wormser
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Clin Infect Dis 43:1089-134. 2006
  2. ncbi Chronic Lyme disease: a review
    Adriana Marques
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA
    Infect Dis Clin North Am 22:341-60, vii-viii. 2008
  3. ncbi Surveillance for Lyme disease--United States, 1992-2006
    Rendi M Bacon
    Division of Vector Borne Infectious Diseases, National Center for Zoonotic Vector Borne and Enteric Diseases, Fort Collins, CO 80521, USA
    MMWR Surveill Summ 57:1-9. 2008
  4. ncbi BosR (BB0647) governs virulence expression in Borrelia burgdorferi
    Zhiming Ouyang
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Microbiol 74:1331-43. 2009
  5. ncbi Borrelia burgdorferi small lipoprotein Lp6.6 is a member of multiple protein complexes in the outer membrane and facilitates pathogen transmission from ticks to mice
    Kamoltip Promnares
    Department of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    Mol Microbiol 74:112-25. 2009
  6. ncbi Borrelia burgdorferi lacking DbpBA exhibits an early survival defect during experimental infection
    Eric H Weening
    Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M Health Science Center, College Station, TX 77843, USA
    Infect Immun 76:5694-705. 2008
  7. ncbi Role of the surface lipoprotein BBA07 in the enzootic cycle of Borrelia burgdorferi
    Haijun Xu
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Infect Immun 78:2910-8. 2010
  8. ncbi Lyme disease
    Thomas S Murray
    Department of Pediatric, Yale University, New Haven, CT 06520 8064, USA
    Clin Lab Med 30:311-28. 2010
  9. ncbi The bba64 gene of Borrelia burgdorferi, the Lyme disease agent, is critical for mammalian infection via tick bite transmission
    Robert D Gilmore
    Bacterial Diseases Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA
    Proc Natl Acad Sci U S A 107:7515-20. 2010
  10. ncbi The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirochete
    Jenny A Hyde
    Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M Health Science Center, College Station, TX 77843 1114, USA
    Mol Microbiol 74:1344-55. 2009

Research Grants

  1. MOLECULAR GENETICS OF LYME ARTHRITIS SUSCEPTIBILITY
    JANIS WEIS; Fiscal Year: 2009
  2. Biophysics of the morphology and motility of Borrelia burgdorferi in diverse envi
    Charles W Wolgemuth; Fiscal Year: 2010
  3. GAMMA DELTA T CELLS IN LYME ARTHRITIS
    Ralph C Budd; Fiscal Year: 2010
  4. GAMMA DELTA T CELLS IN LYME ARTHRITIS
    Ralph Budd; Fiscal Year: 2009
  5. RpoS-mediated virulence regulation in Borrelia burgdorferi
    JON SCOTT BLEVINS; Fiscal Year: 2010
  6. LYME DISEASE IN WESTERN USA--ECOLOGY AND EPIDEMIOLOGY
    Robert Lane; Fiscal Year: 1993
  7. LYME DISEASE IN WESTERN USA--ECOLOGY AND EPIDEMIOLOGY
    Robert Lane; Fiscal Year: 1992
  8. LYME DISEASE IN WESTERN USA: ECOLOGY AND EPIDEMIOLOGY
    Robert Lane; Fiscal Year: 2004
  9. CHRONIC LYME ARTHRITIS--IS THIS AUTOIMMUNITY?
    Brigitte Huber; Fiscal Year: 2000
  10. The role of Borrelia burgdorferi chemotoxis in the pathogenesis of Lyme disease
    Md Motaleb; Fiscal Year: 2007

Detail Information

Publications273 found, 100 shown here

  1. ncbi The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America
    Gary P Wormser
    Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Clin Infect Dis 43:1089-134. 2006
    Evidence-based guidelines for the management of patients with Lyme disease, human granulocytic anaplasmosis (formerly known as human granulocytic ehrlichiosis), and babesiosis were prepared by an expert panel of the Infectious Diseases ..
  2. ncbi Chronic Lyme disease: a review
    Adriana Marques
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA
    Infect Dis Clin North Am 22:341-60, vii-viii. 2008
    Studies have shown that most patients diagnosed with chronic Lyme disease either have no objective evidence of previous or current infection with Borrelia burgdorferi or are patients who should be classified as having post-Lyme disease ..
  3. ncbi Surveillance for Lyme disease--United States, 1992-2006
    Rendi M Bacon
    Division of Vector Borne Infectious Diseases, National Center for Zoonotic Vector Borne and Enteric Diseases, Fort Collins, CO 80521, USA
    MMWR Surveill Summ 57:1-9. 2008
    b>Lyme disease is a multisystem disease that occurs in North America, Europe, and Asia. In the United States, the etiologic agent is Borrelia burgdorferi sensu stricto, a spirochete transmitted to humans by infected Ixodes scapularis and I...
  4. ncbi BosR (BB0647) governs virulence expression in Borrelia burgdorferi
    Zhiming Ouyang
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Microbiol 74:1331-43. 2009
    Summary Borrelia burgdorferi (Bb), the Lyme disease spirochaete, encodes a potential ferric uptake regulator (Fur) homologue, BosR (BB0647)...
  5. ncbi Borrelia burgdorferi small lipoprotein Lp6.6 is a member of multiple protein complexes in the outer membrane and facilitates pathogen transmission from ticks to mice
    Kamoltip Promnares
    Department of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    Mol Microbiol 74:112-25. 2009
    ..burgdorferi persistence and transmission through a complex enzootic cycle...
  6. ncbi Borrelia burgdorferi lacking DbpBA exhibits an early survival defect during experimental infection
    Eric H Weening
    Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M Health Science Center, College Station, TX 77843, USA
    Infect Immun 76:5694-705. 2008
    ..Several Borrelia burgdorferi genes induced under mammalian host conditions have been purported to be important in Lyme disease pathogenesis based on their binding to host structures...
  7. ncbi Role of the surface lipoprotein BBA07 in the enzootic cycle of Borrelia burgdorferi
    Haijun Xu
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Infect Immun 78:2910-8. 2010
    Borrelia burgdorferi, the Lyme disease pathogen, dramatically alters its protein profile when it is transmitted between ticks and mammals...
  8. ncbi Lyme disease
    Thomas S Murray
    Department of Pediatric, Yale University, New Haven, CT 06520 8064, USA
    Clin Lab Med 30:311-28. 2010
    b>Lyme disease, caused by the spirochete Borrelia burgdorferi, is the most common vector-borne disease in the United States...
  9. ncbi The bba64 gene of Borrelia burgdorferi, the Lyme disease agent, is critical for mammalian infection via tick bite transmission
    Robert D Gilmore
    Bacterial Diseases Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA
    Proc Natl Acad Sci U S A 107:7515-20. 2010
    The spirochetal agent of Lyme disease, Borrelia burgdorferi, is transmitted by bites of Ixodes ticks to mammalian reservoir hosts and humans. The mechanism(s) by which the organism is trafficked from vector to host is poorly understood...
  10. ncbi The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirochete
    Jenny A Hyde
    Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M Health Science Center, College Station, TX 77843 1114, USA
    Mol Microbiol 74:1344-55. 2009
    Summary Borrelia burgdorferi, the Lyme disease spirochete, adapts as it moves between the arthropod and mammalian hosts that it infects. We hypothesize that BosR serves as a global regulator in B...
  11. ncbi Role of acetyl-phosphate in activation of the Rrp2-RpoN-RpoS pathway in Borrelia burgdorferi
    Haijun Xu
    Institute of Insect Science, Zhejiang University, Hangzhou, China
    PLoS Pathog 6:e1001104. 2010
    Borrelia burgdorferi, the Lyme disease spirochete, dramatically alters its transcriptome and proteome as it cycles between the arthropod vector and mammalian host...
  12. ncbi Diagnosis of lyme borreliosis
    Maria E Aguero-Rosenfeld
    Department of Pathology, Division of Infectious Diseases, New York Medical College, Valhalla, NY, USA
    Clin Microbiol Rev 18:484-509. 2005
    ..Evaluation of these assays is currently being done, and there is evidence that certain of these antigens may be broadly cross-reactive with the B. burgdorferi sensu lato species causing LB in Europe...
  13. ncbi Identification and function of the RNA chaperone Hfq in the Lyme disease spirochete Borrelia burgdorferi
    Meghan C Lybecker
    Division of Biological Sciences, The University of Montana, Missoula, MT 59812 4824, USA
    Mol Microbiol 78:622-35. 2010
    ..We have identified and characterized an atypical Hfq required for gene regulation and infectivity in the Lyme disease spirochete Borrelia burgdorferi. Sequence analyses of the putative B...
  14. ncbi Distinct cerebrospinal fluid proteomes differentiate post-treatment lyme disease from chronic fatigue syndrome
    Steven E Schutzer
    Department of Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, United States of America
    PLoS ONE 6:e17287. 2011
    Neurologic Post Treatment Lyme disease (nPTLS) and Chronic Fatigue (CFS) are syndromes of unknown etiology. They share features of fatigue and cognitive dysfunction, making it difficult to differentiate them...
  15. ncbi Analysis of the RpoS regulon in Borrelia burgdorferi in response to mammalian host signals provides insight into RpoS function during the enzootic cycle
    Melissa J Caimano
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Mol Microbiol 65:1193-217. 2007
    ....
  16. ncbi Borrelia burgdorferi population kinetics and selected gene expression at the host-vector interface
    Emir Hodzic
    Center for Comparative Medicine, School of Medicine, University of California at Davis, Davis, California 95616, USA
    Infect Immun 70:3382-8. 2002
    ..Evidence of ospA transcription in skin could be found 1 day after tick attachment but not thereafter...
  17. ncbi A new animal model for studying Lyme disease spirochetes in a mammalian host-adapted state
    D R Akins
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Clin Invest 101:2240-50. 1998
    There is now substantial evidence that Borrelia burgdorferi, the Lyme disease spirochete, undergoes major alterations in antigenic composition as it cycles between its arthropod and mammalian hosts. In this report, we cultivated B...
  18. ncbi A new Borrelia species defined by multilocus sequence analysis of housekeeping genes
    Gabriele Margos
    Department of Biology and Biochemistry, University of Bath, 3 South, Claverton Down, Bath BA2 7AY, United Kingdom
    Appl Environ Microbiol 75:5410-6. 2009
    ..We suggest that OspA serotype 4 strains be raised to species status and named Borrelia bavariensis sp. nov. The rooted phylogenetic trees provide novel insights into the evolutionary history of LB spirochetes...
  19. ncbi Functional analysis of the Borrelia burgdorferi bba64 gene product in murine infection via tick infestation
    Toni G Patton
    Microbiology and Pathogenesis Activity, Division of Vector Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA
    PLoS ONE 6:e19536. 2011
    ..Collectively, the results of this study indicate that BBA64 functions at the salivary gland-to-host delivery interface of vector transmission and is not involved in resistance to MyD88-mediated innate immunity...
  20. ncbi Gene regulation in Borrelia burgdorferi
    D Scott Samuels
    Division of Biological Sciences and Biochemistry Program, The University of Montana, Missoula, Montana 59812, USA
    Annu Rev Microbiol 65:479-99. 2011
    Borrelia burgdorferi, the spirochete that causes Lyme disease, is maintained in nature via an enzootic cycle that comprises a tick vector and a vertebrate host...
  21. ncbi Cardiac involvement in non-human primates infected with the Lyme disease spirochete Borrelia burgdorferi
    Diego Cadavid
    Department of Neurology and Neuroscience, UMDNJ New Jersey Medical School, Newark, NJ, USA
    Lab Invest 84:1439-50. 2004
    To investigate cardiac involvement in the non-human primate (NHP) model of Lyme disease, we inoculated 39 adult Macaca mulatta with Borrelia burgdorferi sensu stricto strains N40 (BbN40) by needle (N=22, 14 immunocompetent (IC), seven ..
  22. ncbi CsrA modulates levels of lipoproteins and key regulators of gene expression critical for pathogenic mechanisms of Borrelia burgdorferi
    S L Rajasekhar Karna
    South Texas Center for Emerging Infectious Diseases and Department of Biology, The University of Texas at San Antonio, San Antonio, Texas 78249, USA
    Infect Immun 79:732-44. 2011
    ..The further characterization of molecular basis of regulation mediated by CsrA(Bb) will provide significant insights into the pathophysiology of B. burgdorferi...
  23. ncbi Lyme disease: a review
    Adriana R Marques
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11 N234, Bethesda, MD 20892, USA
    Curr Allergy Asthma Rep 10:13-20. 2010
    b>Lyme disease is the most common vector-borne illness in the United States and is also endemic in Europe and Asia. It is caused by the spirochete Borrelia burgdorferi and transmitted by the bite of the Ixodes (deer) tick...
  24. ncbi Borrelia burgdorferi RevA antigen binds host fibronectin
    Catherine A Brissette
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Chandler Medical Center MN469, Lexington, Kentucky 40536 0298, USA
    Infect Immun 77:2802-12. 2009
    Borrelia burgdorferi, the Lyme disease-causing spirochete, can persistently infect its vertebrate hosts for years. B...
  25. ncbi Use of tick surveys and serosurveys to evaluate pet dogs as a sentinel species for emerging Lyme disease
    Sarah A Hamer
    Department of Fisheries and Wildlife, College of Agricultural and Natural Resources, Michigan State University, East Lansing, MI 48824, USA
    Am J Vet Res 70:49-56. 2009
    To evaluate dogs as a sentinel species for emergence of Lyme disease in a region undergoing invasion by Ixodes scapularis.
  26. ncbi Counterpoint: long-term antibiotic therapy improves persistent symptoms associated with lyme disease
    Raphael B Stricker
    International Lyme and Associated Diseases Society, Bethesda, MD, USA
    Clin Infect Dis 45:149-57. 2007
    Controversy exists regarding the diagnosis and treatment of Lyme disease. Patients with persistent symptoms after standard (2-4-week) antibiotic therapy for this tickborne illness have been denied further antibiotic treatment as a result ..
  27. ncbi The utility of "Google Trends" for epidemiological research: Lyme disease as an example
    Ari Seifter
    Lyme Disease Research Foundation of Maryland, 10755 Falls Road, Lutherville, MD 21093, USA
    Geospat Health 4:135-7. 2010
    ..We report briefly on exploring this resource using Lyme disease as an example because it has well-described seasonal and geographic patterns...
  28. ncbi Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease
    M S Klempner
    New England Medical Center and Tufts University School of Medicine, Boston, MA, USA
    N Engl J Med 345:85-92. 2001
    It is controversial whether prolonged antibiotic treatment is effective for patients in whom symptoms persist after the recommended antibiotic treatment for acute Lyme disease.
  29. ncbi Prevalence and geographic distribution of Dirofilaria immitis, Borrelia burgdorferi, Ehrlichia canis, and Anaplasma phagocytophilum in dogs in the United States: results of a national clinic-based serologic survey
    Dwight Bowman
    Department of Microbiology and Immunology, Cornell College of Veterinary Medicine, C4 119 Veterinary Medical Center, Ithaca, NY 14853, United States
    Vet Parasitol 160:138-48. 2009
    ..Dogs can serve as sentinels to identify the presence of vector-borne disease agents of both veterinary and public health significance...
  30. ncbi Essential role of the response regulator Rrp2 in the infectious cycle of Borrelia burgdorferi
    Bethany K Boardman
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Infect Immun 76:3844-53. 2008
    Alteration of surface lipoprotein profiles is a key strategy that the Lyme disease pathogen, Borrelia burgdorferi, has evolved to be maintained within its enzootic cycle between arthropods and mammals...
  31. ncbi Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks
    Star M Dunham-Ems
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    J Clin Invest 119:3652-65. 2009
    b>Lyme disease is caused by transmission of the spirochete Borrelia burgdorferi from ticks to humans. Although much is known about B. burgdorferi replication, the routes and mechanisms by which it disseminates within the tick remain unclear...
  32. ncbi Transcriptional interplay among the regulators Rrp2, RpoN and RpoS in Borrelia burgdorferi
    Zhiming Ouyang
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Microbiology 154:2641-58. 2008
    ..Although several known B. burgdorferi virulence determinants were regulated by the RpoN-RpoS pathway, a defined function has yet to be ascribed to most of the genes substantially regulated by Rrp2, RpoN and RpoS...
  33. ncbi Role of the BBA64 locus of Borrelia burgdorferi in early stages of infectivity in a murine model of Lyme disease
    Mahulena Maruskova
    South Texas Center for Emerging Infectious Diseases and Department of Biology, The University of Texas at San Antonio, San Antonio, Texas 7824, USA
    Infect Immun 76:391-402. 2008
    Borrelia burgdorferi, the causative agent of Lyme disease, undergoes rapid adaptive gene expression in response to environmental signals encountered during different stages of its life cycle in the arthropod vector or the mammalian host...
  34. ncbi Outer-surface protein C of the Lyme disease spirochete: a protein induced in ticks for infection of mammals
    Dorothee Grimm
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South Fourth Street, Hamilton, MT 59840, USA
    Proc Natl Acad Sci U S A 101:3142-7. 2004
    Environmentally responsive synthesis of surface proteins represents a hallmark of the infectious cycle of the Lyme disease agent, Borrelia burgdorferi. Here we created and analyzed a B...
  35. ncbi Biology of infection with Borrelia burgdorferi
    Kit Tilly
    Laboratory of Zoonotic Pathogens, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA
    Infect Dis Clin North Am 22:217-34, v. 2008
    ..Although infection of these natural hosts does not lead to disease, infection of humans can result in Lyme disease as a consequence of the human immunopathologic response to B burgdorferi...
  36. ncbi Assessment of decorin-binding protein A to the infectivity of Borrelia burgdorferi in the murine models of needle and tick infection
    Jon S Blevins
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    BMC Microbiol 8:82. 2008
    Decorin-binding proteins (Dbps) A and B of Borrelia burgdorferi, the agent of Lyme disease, are surface-exposed lipoproteins that presumably bind to the extracellular matrix proteoglycan, decorin. B...
  37. ncbi Treg cell numbers and function in patients with antibiotic-refractory or antibiotic-responsive Lyme arthritis
    Shiqian Shen
    Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Arthritis Rheum 62:2127-37. 2010
    ..In a murine model of antibiotic-refractory Lyme arthritis, the numbers of Treg cells are dramatically reduced. The aim of this study was to examine Treg cell numbers and function in patients with antibiotic-refractory Lyme arthritis...
  38. ncbi Detection of Borrelia burgdorferi sensu lato DNA by PCR in serum of patients with clinical symptoms of Lyme borreliosis
    Iolanda Santino
    Department of Public Health Sciences, Sapienza University of Rome, Rome, Italy
    FEMS Microbiol Lett 283:30-5. 2008
    ..burgdorferi s.l. and Borrelia genospecies DNAs in serum samples collected from patients showing Lyme disease symptoms. Of 265 serum samples of patients included in this study, 7.5% were positive, 1...
  39. ncbi Invasion of eukaryotic cells by Borrelia burgdorferi requires β(1) integrins and Src kinase activity
    Jing Wu
    407 Reynolds Medical Building, Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M Health Science Center, College Station, TX 77843 1114, USA
    Infect Immun 79:1338-48. 2011
    b>Lyme disease, caused by the bacterium Borrelia burgdorferi, is the most widespread tick-borne infection in the northern hemisphere that results in a multistage disorder with concomitant pathology, including arthritis...
  40. ncbi Genotypic variation and mixtures of Lyme Borrelia in Ixodes ticks from North America and Europe
    Chris D Crowder
    Ibis Biosciences, Carlsbad, California, United States of America
    PLoS ONE 5:e10650. 2010
    b>Lyme disease, caused by various species of Borrelia, is transmitted by Ixodes ticks in North America and Europe. Studies have shown the genotype of Borrelia burgdorferi sensu stricto (s.s.) or the species of B. burgdorferi sensu lato (s.l...
  41. ncbi Deletion of BBA64, BBA65, and BBA66 loci does not alter the infectivity of Borrelia burgdorferi in the murine model of Lyme disease
    Mahulena Maruskova
    South Texas Center for Emerging Infectious Diseases and Department of Biology, The University of Texas at San Antonio, San Antonio, Texas 78249, USA
    Infect Immun 76:5274-84. 2008
    Borrelia burgdorferi, the causative agent of Lyme disease, alters its gene expression in response to highly disparate environmental signals encountered in its tick vector versus vertebrate hosts...
  42. ncbi Cloning of a salivary gland metalloprotease and characterization of gelatinase and fibrin(ogen)lytic activities in the saliva of the Lyme disease tick vector Ixodes scapularis
    Ivo M B Francischetti
    Medical Entomology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Room 126, Building 4, 4 Center Drive, MSC 0425, Bethesda, MD 20892 0425, USA
    Biochem Biophys Res Commun 305:869-75. 2003
    ..This is the first description of such activity in tick saliva and its role in tick feeding and Borrelia transmission is discussed...
  43. ncbi Infection and inflammation in skeletal muscle from nonhuman primates infected with different genospecies of the Lyme disease spirochete Borrelia burgdorferi
    Diego Cadavid
    Department of Neuroscience, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    Infect Immun 71:7087-98. 2003
    ..To investigate muscle involvement in the nonhuman primate (NHP) model of Lyme disease, 16 adult Macaca mulatta animals inoculated with strain N40 of B...
  44. ncbi Evidence-based guidelines for the management of Lyme disease
    Daniel Cameron
    ILADS, P.O. Box 341461, Bethesda, MD 20827-1461, USA
    Expert Rev Anti Infect Ther 2:S1-13. 2004
    This report, completed in November 2003, is intended to serve as a resource for physicians, public health officials and organizations involved in the evaluation and treatment of Lyme disease.
  45. ncbi Microbiological and serological diagnosis of Lyme borreliosis
    Bettina Wilske
    Max von Pettenkofer Institute, University of Munich, National Reference Centre for Borreliae, Munich, Germany
    FEMS Immunol Med Microbiol 49:13-21. 2007
    ..Cerebrospinal fluid is positive in only 10-30%. Methods that are not recommended for diagnostic purposes include antigen tests in body fluids, PCR of urine and lymphocyte transformation tests...
  46. ncbi Consequences of treatment delay in Lyme disease
    Daniel J Cameron
    J Eval Clin Pract 13:470-2. 2007
  47. ncbi Lyme disease: scratching the surface
    Steven E Phillips
    Lancet 366:1771. 2005
  48. ncbi Impact of clinical variables on Borrelia burgdorferi-specific antibody seropositivity in acute-phase sera from patients in North America with culture-confirmed early Lyme disease
    Gary P Wormser
    Department of Medicine, Division of Infectious Diseases, Munger Pavilion Room 245, New York Medical College, Valhalla, NY 10595, USA
    Clin Vaccine Immunol 15:1519-22. 2008
    Erythema migrans, the most common manifestation of Lyme disease, has been associated with highly variable rates of seropositivity for antibodies to Borrelia burgdorferi...
  49. ncbi Ineffectiveness of tigecycline against persistent Borrelia burgdorferi
    Stephen W Barthold
    Center for Comparative Medicine, School of Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA
    Antimicrob Agents Chemother 54:643-51. 2010
    ..burgdorferi genes. These results extended previous studies with ceftriaxone, indicating that antibiotic treatment is unable to clear persisting spirochetes, which remain viable and infectious, but are nondividing or slowly dividing...
  50. ncbi Decreased up-regulation of the interleukin-12Rbeta2-chain and interferon-gamma secretion and increased number of forkhead box P3-expressing cells in patients with a history of chronic Lyme borreliosis compared with asymptomatic Borrelia-exposed individual
    S Jarefors
    Division of Clinical Immunology, Faculty of Health Sciences, University of Linkoping, Sweden
    Clin Exp Immunol 147:18-27. 2007
    ..In addition, regulatory T cells might also play a role, by immunosuppression, in the development of chronic LB...
  51. ncbi Lyme borreliosis in dogs and humans in the USA
    Susan E Little
    Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA
    Trends Parasitol 26:213-8. 2010
    ....
  52. ncbi P66 porins are present in both Lyme disease and relapsing fever spirochetes: a comparison of the biophysical properties of P66 porins from six Borrelia species
    Iván Bárcena-Uribarri
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, Wurzburg, Germany
    Biochim Biophys Acta 1798:1197-203. 2010
    The genus Borrelia is the cause of the two human diseases: Lyme disease (LD) and relapsing fever (RF). Both LD and RF Borrelia species are obligate parasites and are dependent on nutrients provided by their hosts...
  53. ncbi Ecological niche modeling of lyme disease in British Columbia, Canada
    Sunny Mak
    Epidemiology Services, British Columbia Centre for Disease Control, 655 West 12th Avenue, Vancouver, BC, Canada, V5Z 4R4
    J Med Entomol 47:99-105. 2010
    ..pacificus (Cooley & Kohls), and Ixodes angustus (Neumann), the bacterium and primary tick vectors for Lyme disease, in British Columbia (BC), Canada...
  54. ncbi Persistence of borrelial DNA in the joints of Borrelia burgdorferi-infected mice after ceftriaxone treatment
    Heta Yrjänäinen
    Department of Medical Microbiology and Immunology, University of Turku, Finland
    APMIS 118:665-73. 2010
    ..In conclusion, these results combined with earlier results suggest that the joint or a tissue adjacent to the joint is the niche of persisting B. burgdorferi in ceftriaxone-treated mice...
  55. ncbi Lyme borreliosis: clinical case definitions for diagnosis and management in Europe
    G Stanek
    Medical University of Vienna, Department of Hygiene and Applied Immunology, Vienna, Austria
    Clin Microbiol Infect 17:69-79. 2011
    ..These new case definitions for European Lyme borreliosis emphasise recognition of clinical manifestations supported by relevant laboratory criteria and may be used in a clinical setting and also for epidemiological investigations...
  56. ncbi BosR (BB0647) controls the RpoN-RpoS regulatory pathway and virulence expression in Borrelia burgdorferi by a novel DNA-binding mechanism
    Zhiming Ouyang
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS Pathog 7:e1001272. 2011
    In Borrelia burgdorferi (Bb), the Lyme disease spirochete, the alternative σ factor σ⁵⁴ (RpoN) directly activates transcription of another alternative σ factor, σ(S) (RpoS) which, in turn, controls the expression of virulence-..
  57. ncbi Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes
    Justin D Radolf
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Nat Rev Microbiol 10:87-99. 2012
    In little more than 30 years, Lyme disease, which is caused by the spirochaete Borrelia burgdorferi, has risen from relative obscurity to become a global public health problem and a prototype of an emerging infection...
  58. ncbi Ixodes ricinus as a vector of Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum and Babesia microti in urban and suburban forests
    Joanna Stanczak
    Medical University of Gdansk, Interfaculty Institute of Maritime and Tropical Medicine, 9B Powstania Styczniowego str, 81 519 Gdynia, Poland
    Ann Agric Environ Med 11:109-14. 2004
    ..These microorganisms include etiologic agents of Lyme disease, human anaplasmosis (HA) and babesiosis: Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum and Babesia ..
  59. ncbi Effect of complement component C3 deficiency on experimental Lyme borreliosis in mice
    Matthew B Lawrenz
    Program in Microbiology and Molecular Genetics and Department of Pathology and Laboratory Medicine, Graduate School of Biomedical Sciences, University of Texas Houston Health Science Center, Houston, Texas, USA
    Infect Immun 71:4432-40. 2003
    ..garinii. These results indicate that the complement system may be important in controlling the early dissemination and progression of B. burgdorferi infection...
  60. ncbi Detection of attenuated, noninfectious spirochetes in Borrelia burgdorferi-infected mice after antibiotic treatment
    Linda K Bockenstedt
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8031, USA
    J Infect Dis 186:1430-7. 2002
    ..These results provide evidence that noninfectious spirochetes can persist for a limited duration after antibiotics but are not associated with disease in mice...
  61. ncbi Lyme disease diagnosis and treatment: lessons from the AIDS epidemic
    R B Stricker
    International Lyme and Associated Diseases Society, Bethesda, MD, USA
    Minerva Med 101:419-25. 2010
    b>Lyme disease is a controversial tick-borne illness that is estimated to be four times more common than AIDS in the United States...
  62. ncbi Binding of the complement inhibitor C4b-binding protein to Lyme disease Borreliae
    Johanna Pietikäinen
    Haartman Institute, Department of Bacteriology and Immunology, University of Helsinki, HUSLAB, Helsinki, Finland
    Mol Immunol 47:1299-305. 2010
    The Lyme disease spirochetes, Borrelia burgdorferi sensu stricto, Borrelia afzelii and Borrelia garinii, are tick-borne pathogens that can cause chronic disseminated infections...
  63. ncbi Carbohydrate utilization by the Lyme borreliosis spirochete, Borrelia burgdorferi
    Kate von Lackum
    Department of Microbiology, Immunology, and Molecular Genetics, College of Medicine, University of Kentucky, Lexington, KY 40536-0298, USA
    FEMS Microbiol Lett 243:173-9. 2005
    ..burgdorferi during infection of either vertebrate and arthropod hosts, enabling development of a model describing energy sources potentially used by the Lyme borreliosis spirochete during its natural infectious cycle...
  64. ncbi 'Lyme disease': ancient engine of an unrecognized borreliosis pandemic?
    W T Harvey
    Diversified Medical Practices, Texas, Houston, USA
    Med Hypotheses 60:742-59. 2003
    ..prior to sufficient data availability, we chose to examine critically currently accepted but troublesome 'Lyme disease' concepts...
  65. ncbi Comparative transcriptional profiling of Borrelia burgdorferi clinical isolates differing in capacities for hematogenous dissemination
    Caroline Ojaimi
    Department of Microbiology and Immunology, New York Medical College, Valhalla, 10595, USA
    Infect Immun 73:6791-802. 2005
    Borrelia burgdorferi, the etiologic agent of Lyme disease, is genetically heterogeneous...
  66. ncbi Persistence of Borrelia burgdorferi following antibiotic treatment in mice
    Emir Hodzic
    Center for Comparative Medicine, School of Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA
    Antimicrob Agents Chemother 52:1728-36. 2008
    ..Results indicated that following antibiotic treatment, mice remained infected with nondividing but infectious spirochetes, particularly when antibiotic treatment was commenced during the chronic stage of infection...
  67. ncbi Variations in Barbour-Stoenner-Kelly culture medium modulate infectivity and pathogenicity of Borrelia burgdorferi clinical isolates
    Guiqing Wang
    Department of Microbiology and Immunology, New York Medical College, Valhalla 10595, USA
    Infect Immun 72:6702-6. 2004
    ..The data suggest that variations in BSK medium have a significant impact on the infectivity and pathogenicity of B. burgdorferi clinical isolates...
  68. ncbi Comparison of five different immunoassays for the detection of Borrelia burgdorferi IgM and IgG antibodies
    A Smismans
    Department of Medical Microbiology, University Hospital Maastricht, Maastricht, The Netherlands
    Clin Microbiol Infect 12:648-55. 2006
    ..Sensitivity was assessed with European serum samples collected from 45 patients with clinically defined Lyme disease in conjunction with a positive immunoblot (n = 44) or other serological test (n = 1)...
  69. ncbi Sex-biased genetic structure in the vector of Lyme disease, Ixodes ricinus
    Thierry de Meeus
    Centre d Etude sur le Polymorphisme des Micro Organismes CEPM UMR CNRS IRD 9926, Montpellier, France
    Evolution 56:1802-7. 2002
    We analyzed 725 Ixodes ricinus ticks (the principal vector of Lyme disease in Europe) collected in Switzerland in 1995 and 1996 (three and eight samples, respectively) and in Tunisia in 1996 (one sample) with five microsatellite markers...
  70. ncbi Recognition of Borrelia burgdorferi by NOD2 is central for the induction of an inflammatory reaction
    Marije Oosting
    Department of Medicine, Nijmegen Institute of Infection, Inflammation, and Immunity, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Infect Dis 201:1849-58. 2010
    ..receptor 2 (TLR2) plays an important role in the recognition of Borrelia bacteria, the causative agent of Lyme disease, but the existence and importance of additional receptors in this process has been hypothesized...
  71. ncbi Point: antibiotic therapy is not the answer for patients with persisting symptoms attributable to lyme disease
    Paul G Auwaerter
    Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Clin Infect Dis 45:143-8. 2007
    ..aches, and neurocognitive dysfunction after receiving standard antibiotic courses for the treatment of Lyme disease. Some practitioners use the term "chronic Lyme disease" and order prolonged courses of oral and ..
  72. ncbi A manganese transporter, BB0219 (BmtA), is required for virulence by the Lyme disease spirochete, Borrelia burgdorferi
    Zhiming Ouyang
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 106:3449-54. 2009
    Borrelia burgdorferi (Bb), the causative agent of Lyme disease, is transmitted to mammalian hosts through an arthropod (tick) vector...
  73. ncbi Prevalence of four species of Borrelia burgdorferi sensu lato and coinfection with Anaplasma phagocytophila in Ixodes ricinus ticks in central Germany
    A Hildebrandt
    Institute of Medical Microbiology, Friedrich-Schiller-University, Semmelweisstrasse 4, 07743 Jena, Germany
    Eur J Clin Microbiol Infect Dis 22:364-7. 2003
    ..4%), Borrelia afzelii (17.6%), and Borrelia valaisiana (5.9%). Four ticks had dual infection with Borrelia garinii and Borrelia burgdorferi sensu stricto. Two of the Borrelia-positive ticks were coinfected with Anaplasma phagocytophila...
  74. ncbi Decreased CD57 lymphocyte subset in patients with chronic Lyme disease
    R B Stricker
    Department of Medicine, California Pacific Medical Center, 450 Sutter Street, Suite 1504, San Francisco, CA 94108, USA
    Immunol Lett 76:43-8. 2001
    Chronic Lyme disease (LD) is a debilitating illness caused by tickborne infection with the spirochete Borrelia burgdorferi...
  75. ncbi Laboratory diagnostic techniques for patients with early Lyme disease associated with erythema migrans: a comparison of different techniques
    J Nowakowski
    Division of Infectious Diseases and Department of Medicine, New York Medical College and Westchester Medical Center, Valhalla, NY, 10595, USA
    Clin Infect Dis 33:2023-7. 2001
    ..burgdorferi infection. No single diagnostic modality is suitable for detection of B. burgdorferi in every patient with erythema migrans...
  76. ncbi Borrelia burgdorferi-specific monoclonal antibodies derived from mice primed with Lyme disease spirochete-infected Ixodes scapularis ticks
    M Lamine Mbow
    Department of Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Hybrid Hybridomics 21:179-82. 2002
    ..The data presented here suggest that the production of MAbs from animals infected by tick-bite is a potentially useful tool for the identification of novel proteins synthesized by B. burgdorferi during mammalian infection...
  77. ncbi Study and treatment of post Lyme disease (STOP-LD): a randomized double masked clinical trial
    L B Krupp
    Department of Neurology, Stony Brook University Medical Center, Stony Brook, NY 11794 8121, USA
    Neurology 60:1923-30. 2003
    ..To determine whether post Lyme syndrome (PLS) is antibiotic responsive...
  78. ncbi Persistence of Borrelia burgdorferi in experimentally infected dogs after antibiotic treatment
    R K Straubinger
    James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Clin Microbiol 35:111-6. 1997
    ..Antibody levels in untreated infected control dogs remained high...
  79. ncbi Antibodies against a tick protein, Salp15, protect mice from the Lyme disease agent
    Jianfeng Dai
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell Host Microbe 6:482-92. 2009
    Traditionally, vaccines directly target a pathogen or microbial toxin. Lyme disease, caused by Borrelia burgdorferi, is a tick-borne illness for which a human vaccine is not currently available. B...
  80. ncbi Oral immunization with recombinant lactobacillus plantarum induces a protective immune response in mice with Lyme disease
    Beatriz del Rio
    Department of Microbiology and Immunology, New York Medical College, Valhalla, New York, USA
    Clin Vaccine Immunol 15:1429-35. 2008
    ..In this study, we used the Lyme disease mouse model as a proof of concept...
  81. ncbi Marginal zone B-cell depletion impairs murine host defense against Borrelia burgdorferi infection
    Alexia A Belperron
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Infect Immun 75:3354-60. 2007
    ..In this study, we examined the effects of MZB cell depletion on the immune response to the Lyme disease spirochete Borrelia burgdorferi, an extracellular pathogen for which T-cell-independent antibody is an ..
  82. ncbi Treatment of Lyme disease: a medicolegal assessment
    Lorraine Johnson
    California Lyme Disease Association, Ukiah, CA 95482, USA
    Expert Rev Anti Infect Ther 2:533-57. 2004
    b>Lyme disease is the most common tick-borne disease in the world today...
  83. ncbi PCR-Based quantification of Borrelia burgdorferi organisms in canine tissues over a 500-Day postinfection period
    R K Straubinger
    James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Clin Microbiol 38:2191-9. 2000
    ..Only 1.6% of 576 blood samples of all dogs were positive for B. burgdorferi by PCR...
  84. ncbi The role of lizards in the ecology of Lyme disease in two endemic zones of the northeastern United States
    Sean T Giery
    Institute of Ecosystem Studies, Box AB, Route 44A, Millbrook, New York 12545, USA
    J Parasitol 93:511-7. 2007
    We examined the role of lizards in the ecology of Lyme disease in New York and Maryland...
  85. ncbi Comparison of in vitro activities of ketolides, macrolides, and an azalide against the spirochete Borrelia burgdorferi
    Klaus Peter Hunfeld
    Institute of Medical Microbiology, University Hospital of Frankfurt, D 60596 Frankfurt Main, Germany
    Antimicrob Agents Chemother 48:344-7. 2004
    ..0019 micro g/ml) and telithromycin (MIC(90), 0.0078 micro g/ml). Electron-microscope analysis and time-kill studies also supported enhanced effectiveness of both ketolides...
  86. ncbi Borrelia burgdorferi RST1 (OspC type A) genotype is associated with greater inflammation and more severe Lyme disease
    Klemen Strle
    Division of Rheumatology, Allergy and Immunology, the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Pathol 178:2726-39. 2011
    ..Thus, the B. burgdorferi RST1 (OspC type A) genotype, followed by the RST3 (OspC type I) genotype, causes greater inflammation and more severe disease, establishing a link between spirochetal virulence and host inflammation...
  87. ncbi Appropriateness of Lyme disease serologic testing
    Alan H Ramsey
    Bureau of Communicable Diseases, Wisconsin Division of Public Health, Madison, WI, USA
    Ann Fam Med 2:341-4. 2004
    BACKGROUND: Although rapid diagnosis of Lyme disease is essential for effective treatment, there is concern about inappropriate testing...
  88. ncbi Efficacy of antibiotic prophylaxis for the prevention of Lyme disease: an updated systematic review and meta-analysis
    Stephen Warshafsky
    Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    J Antimicrob Chemother 65:1137-44. 2010
    The clinical value of antibiotic prophylaxis in preventing Lyme disease remains uncertain, owing to a meta-analysis lacking sufficient power to demonstrate efficacy and a more recent trial showing effectiveness but lacking precision...
  89. ncbi Role of Borrelia burgdorferi linear plasmid 25 in infection of Ixodes scapularis ticks
    Keith O Strother
    Department of Microbiology and Immunology, CB no. 7290, University of North Carolina, Chapel Hill, NC 27599, USA
    J Bacteriol 187:5776-81. 2005
    ..In addition, the number of infected ticks decreased over time, suggesting that another gene(s) on lp25 is required for long-term persistence in ticks and completion of a natural infection cycle...
  90. ncbi Quality of Lyme disease serology. Lessons from the German Proficiency Testing Program 1999-2001. A preliminary report
    Klaus Peter Hunfeld
    Central Laboratory of the German Proficiency Testing Program for Bacteriological Infection Serology, Institute of Medical Microbiology, University Hospital of Frankfurt Main, Germany
    Wien Klin Wochenschr 114:591-600. 2002
    ..We report on the results of a Lyme disease proficiency testing program which is regularly organised twice a year by our institutions in close cooperation ..
  91. ncbi An appraisal of "chronic Lyme disease"
    Lawrence Mayer
    N Engl J Med 358:428; author reply 430-1. 2008
  92. ncbi Detection and molecular typing of Borrelia burgdorferi sensu lato in Ixodes ricinus ticks and in different patient samples from southwest Germany
    D Schaarschmidt
    Fachbereich Biologie, Universitat Konstanz, Universitätsstrasse, Konstanz, Germany
    Eur J Epidemiol 17:1067-74. 2001
    ..Borrelia afzelii is the predominant genospecies in all kind of samples from the observed area and there seems to be no association of particular Borrelia genospecies with distinct clinical manifestations of LB...
  93. ncbi Contributions of societal and geographical environments to "chronic Lyme disease": the psychopathogenesis and aporology of a new "medically unexplained symptoms" syndrome
    Leonard H Sigal
    Division of Rheumatology and Connective Tissue Research, Department of Medicine, Lyme Disease Center, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903 0019, USA
    Environ Health Perspect 110:607-11. 2002
    b>Lyme disease is a relatively well-described infectious disease with multisystem manifestations...
  94. ncbi C-terminal invariable domain of VlsE is immunodominant but its antigenicity is scarcely conserved among strains of Lyme disease spirochetes
    F T Liang
    Department of Parasitology, Tulane Regional Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
    Infect Immun 69:3224-31. 2001
    ..inoculation were positive by the Ct ELISA, while only 5 of 18 serum samples from dogs clinically diagnosed with Lyme disease contained detectable anti-Ct antibody...
  95. ncbi Serum time course of two brain-specific proteins, alpha(1) brain globulin and neuron-specific enolase, in tick-born encephalitis and Lyme disease
    Vladimir P Chekhonin
    Laboratory of Immunochemistry, Serbsky National Research Centre for Social and Forensic Psychiatry, Kropotkinsky per 23, 119839 Moscow, Russia
    Clin Chim Acta 320:117-25. 2002
    ..and neuron-specific enolase (NSE), were studied in patients with severe tick-born encephalitis (TBE) and Lyme disease (LD; neuroborreliosis)...
  96. ncbi Lone star tick-infecting borreliae are most closely related to the agent of bovine borreliosis
    S M Rich
    Division of Infectious Disease, Tufts University School of Veterinary Medicine, North Grafton, Massachusetts, USA
    J Clin Microbiol 39:494-7. 2001
    ..bovine borreliosis, was described at the turn of the century (in 1903), its relationship with borreliae causing Lyme disease or relapsing fever remains undescribed...
  97. ncbi Severity of Lyme disease with persistent symptoms. Insights from a double-blind placebo-controlled clinical trial
    D Cameron
    Northern Westchester Hospital, Mount Kisco, NY, USA
    Minerva Med 99:489-96. 2008
    b>Lyme disease is a global health concern and is the world's leading tick borne infection caused by the spirochete, Borrelia burgdorferi, that has been associated with numerous neurologic, rheumatologic and psychiatric manifestations...
  98. ncbi Interactions of OspA monoclonal antibody C3.78 with Borrelia burgdorferi within ticks
    Clay L Gipson
    Department of Microbiology and Immunology, CB#7290, University of North Carolina, Chapel Hill, NC 27599, USA
    Infect Immun 73:1644-7. 2005
    ..We propose that OspA antibody binding to the surface of spirochetes blocks transmission by a mechanism that does not require bacterial killing...
  99. ncbi Lyme borreliosis agents and the genetics and sex of their vector, Ixodes ricinus
    Thierry de Meeus
    Centre d Etude sur le Polymorphisme des Micro Organismes, UMR CNRS IRD 9926, Equipe Evolution des Systèmes Symbiotiques, Unite Mixte de Recherches, 911 Avenue d Agropolis, B P 64501, 34394 Montpellier Cedex 5, France
    Microbes Infect 6:299-304. 2004
    ..transmission and maintenance of a wide variety of pathogenic organisms in the Northern Hemisphere, among which Lyme disease represents a major threat to humans...
  100. ncbi The dog as a sentinel for human infection: prevalence of Borrelia burgdorferi C6 antibodies in dogs from southeastern and mid-Atlantic States
    Ashlee W Duncan
    Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine (NCSU-CVM, Raleigh, North Carolina 27606, USA
    Vector Borne Zoonotic Dis 5:101-9. 2005
    b>Lyme disease is the most frequently reported human vector-associated disease in the United States. Infection occurs after the bite of an Ixodid tick that is infected with Borrelia burgdorferi...
  101. ncbi Borreliacidal OspC antibodies specific for a highly conserved epitope are immunodominant in human lyme disease and do not occur in mice or hamsters
    Steven D Lovrich
    Microbiology Research Laboratory, Gundersen Lutheran Medical Center, 1300 Badger Street, La Crosse, WI 54601, USA
    Clin Diagn Lab Immunol 12:746-51. 2005
    ..Six early Lyme disease sera that contained borreliacidal activity and IgM and/or IgG OspC antibodies were chosen randomly and adsorbed ..

Research Grants89

  1. MOLECULAR GENETICS OF LYME ARTHRITIS SUSCEPTIBILITY
    JANIS WEIS; Fiscal Year: 2009
    ..Identification of the genes that regulate disease severity will provide insight into the mechanism of arthritis development and may be extended to other inflammatory pathologies. ..
  2. Biophysics of the morphology and motility of Borrelia burgdorferi in diverse envi
    Charles W Wolgemuth; Fiscal Year: 2010
    ..If untreated, Lyme disease can lead to a wide array of complications typically involving the heart, joints, or nervous system...
  3. GAMMA DELTA T CELLS IN LYME ARTHRITIS
    Ralph C Budd; Fiscal Year: 2010
    b>Lyme Disease is the most common vector-borne illness in the U.S. and is caused by transmission of the spirochete, Borrelia burgdorferi, via the tick Ixodes scapularis...
  4. GAMMA DELTA T CELLS IN LYME ARTHRITIS
    Ralph Budd; Fiscal Year: 2009
    b>Lyme Disease is the most common vector-borne illness in the U.S. and is caused by transmission of the spirochete, Borrelia burgdorferi, via the tick Ixodes scapularis...
  5. RpoS-mediated virulence regulation in Borrelia burgdorferi
    JON SCOTT BLEVINS; Fiscal Year: 2010
    During its natural lifecycle, the Lyme disease spirochete, Borrelia burgdorferi, occupies both an arthropod tick vector and a mammalian host...
  6. LYME DISEASE IN WESTERN USA--ECOLOGY AND EPIDEMIOLOGY
    Robert Lane; Fiscal Year: 1993
    The broad objectives of this research are to expand ongoing studies of the mechanisms and routes by which the Lyme disease (LD) spirochete, Borrelia burgdorferi (Bb), is maintained and distributed among wildlife and humans in a highly ..
  7. LYME DISEASE IN WESTERN USA--ECOLOGY AND EPIDEMIOLOGY
    Robert Lane; Fiscal Year: 1992
    The broad objectives of this research are to investigate further the mechanisms whereby the Lyme disease (LD) spirochete, Borrelia burgdorferi (Bb), is perpetuated and disseminated in natural foic including modes of transmission to humans ..
  8. LYME DISEASE IN WESTERN USA: ECOLOGY AND EPIDEMIOLOGY
    Robert Lane; Fiscal Year: 2004
    ..The broad objectives of this research are to determine environmental correlates of natural foci of the Lyme disease (LD) spirochete, Borrelia burgdorferi sensu stricto (Bb ss) and closely related spirochetes in the Bb sensu ..
  9. CHRONIC LYME ARTHRITIS--IS THIS AUTOIMMUNITY?
    Brigitte Huber; Fiscal Year: 2000
    b>Lyme disease is a multi-faceted illness, initiated upon infection with the spirochete borrelia burgdorferi (Bb)...
  10. The role of Borrelia burgdorferi chemotoxis in the pathogenesis of Lyme disease
    Md Motaleb; Fiscal Year: 2007
    b>Lyme disease is the most prevalent arthropod borne infection in the United States. The disease is caused by the spirochete Borrelia burgdorferi, which is transmitted to humans via infected Ixodes ticks...
  11. LYME ARTHRITIS: A NEW EPIDEMIC DISEASE
    Allen Steere; Fiscal Year: 1993
    b>Lyme disease, which affects both children and adults, is caused by the tickborne spirochete, Borrelia burgdorferi...
  12. Suppressor of Cytokine Signaling and Control of Inflammation in Lyme Disease
    VIDA DENNIS; Fiscal Year: 2007
    b>Lyme disease, caused by the spirochete Borrelia burgdorferi, is an emerging infectious disease, and therefore, of major public health significance...
  13. BAIT VACCINE AGAINST LYME BORRELIOSIS
    Maria Gomes Solecki; Fiscal Year: 2007
    b>Lyme disease is caused by the spirochete Borrelia burgdorferi. This zoonosis is the most prevalent vector borne infectious disease in the United States and Europe and it continues to grow geographically...
  14. Chronic Lyme Arthritis: Is this Autoimmunity?
    Brigitte Huber; Fiscal Year: 2005
    b>Lyme disease is a multifaceted illness, initiated upon infection with the spirochete Borrelia burgdorferi (Bb)...
  15. BORRELIA BURGDORFERI MITOGEN IN DEVELOPMENT OF ARTHRITIS
    Janis J Weis; Fiscal Year: 2010
    ..Project Narrative: Two distinct types of responses have been identified in mice infected with the agent of Lyme disease, Borrelia burgdorferi...
  16. BORRELIA BURGDORFERI MITOGEN IN DEVELOPMENT OF ARTHRITIS
    JANIS WEIS; Fiscal Year: 2009
    ..Project Narrative: Two distinct types of responses have been identified in mice infected with the agent of Lyme disease, Borrelia burgdorferi...
  17. HEALTH BURDERN OF COINFECTING DEER ASSOCIATED ZOONOSES
    Peter Krause; Fiscal Year: 2001
    Although public attention has focused largely on Lyme disease, an array of spirochetal, protozoan, viral and rickettsial pathogens concurrently infect residents of sites in the eastern US in which deer are abundant...
  18. DbpA/B proteins of Borrelia burgdorferi & Lyme arthritis
    Nikhat Parveen; Fiscal Year: 2005
    b>Lyme disease presents a unique clinical system to study cellular and molecular mecahnisms responsible for chronic inflammatory diseases...
  19. Pathogenesis of Borrelia burgdorferi induced arthritis
    Linden Hu; Fiscal Year: 2006
    DESCRIPTION (provided by the applicant): Arthritis is a late manifestation of Lyme disease. Allowed to progress untreated, Lyme arthritis can result in a severe, erosive arthritis...
  20. Biodiversity, Habitat Fragmentation, & Lyme Disease Risk
    RICHARD OSTFELD; Fiscal Year: 2003
    ..and the ecological landscapes in which vectors, pathogens, hosts, and humans interact to affect exposure to Lyme disease. We focus on Lyme disease because of its high incidence, widespread distribution, large body of ecological and ..
  21. Prevention of Lyme Disease in Connecticut
    Matthew Cartter; Fiscal Year: 2007
    The emergence of Lyme disease (LD) as a public health problem in Connecticut over the last 28 years is due to the increased risk of tick bites among persons who live increasingly in suburban and rural areas near woodlands in Connecticut...
  22. Borrelia burgdorferi tick phase genes and Lyme disease pathogenesis
    IRA S SCHWARTZ; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Lyme disease, the most commonly reported arthropod-borne disease in the United States, is caused by infection with the spirochete, Borrelia burgdorferi. Maintenance of B...
  23. Biodiversity, Habitat Fragmentation, & Lyme Disease Risk
    RICHARD OSTFELD; Fiscal Year: 2006
    ..and the ecological landscapes in which vectors, pathogens, hosts, and humans interact to affect exposure to Lyme disease. We focus on Lyme disease because of its high incidence, widespread distribution, large body of ecological and ..
  24. MOLECULAR GENETICS OF LYME ARTHRITIS SUSCEPTIBILITY
    Janis J Weis; Fiscal Year: 2010
    ..Identification of the genes that regulate disease severity will provide insight into the mechanism of arthritis development and may be extended to other inflammatory pathologies. ..
  25. GAMMA DELTA T CELLS IN LYME ARTHRITIS
    Ralph Budd; Fiscal Year: 2005
    b>Lyme disease is the most common vector-borne disease in the United States. It is caused by the spirochete Borrelia burgdorferi and transmitted by lxodes ticks...