ehrlichiosis

Summary

Summary: A tick-borne disease characterized by FEVER; HEADACHE; myalgias; ANOREXIA; and occasionally RASH. It is caused by several bacterial species and can produce disease in DOGS; CATTLE; SHEEP; GOATS; HORSES; and humans. The primary species causing human disease are EHRLICHIA CHAFFEENSIS; ANAPLASMA PHAGOCYTOPHILUM; and Ehrlichia ewingii.

Top Publications

  1. pmc Human ehrlichiosis and anaplasmosis
    Nahed Ismail
    Department of Pathology, Meharry Medical College, Nashville, TN 37208, USA
    Clin Lab Med 30:261-92. 2010
  2. ncbi The natural history of Anaplasma phagocytophilum
    Zerai Woldehiwet
    University of Liverpool, Department of Veterinary Pathology, Veterinary Teaching Hospital, Leahurst, Neston, South Wirral CH64 7TE, UK
    Vet Parasitol 167:108-22. 2010
  3. pmc Delineating Anaplasma phagocytophilum ecotypes in coexisting, discrete enzootic cycles
    Kevin J Bown
    University of Liverpool, Liverpool, UK
    Emerg Infect Dis 15:1948-54. 2009
  4. pmc Distinct host species correlate with Anaplasma phagocytophilum ankA gene clusters
    Wiebke Scharf
    Institute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    J Clin Microbiol 49:790-6. 2011
  5. pmc Ehrlichia chaffeensis and Anaplasma phagocytophilum lack genes for lipid A biosynthesis and incorporate cholesterol for their survival
    Mingqun Lin
    Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA
    Infect Immun 71:5324-31. 2003
  6. ncbi Nosocomial transmission of human granulocytic anaplasmosis in China
    Lijuan Zhang
    National Institute of Communicable Disease Control and Prevention, China, CDC, Beijing, China, PO Box 5, Changping, Beijing, China 102206
    JAMA 300:2263-70. 2008
  7. ncbi Anaplasma phagocytophilum AnkA secreted by type IV secretion system is tyrosine phosphorylated by Abl-1 to facilitate infection
    Mingqun Lin
    Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
    Cell Microbiol 9:2644-57. 2007
  8. pmc Mechanisms of obligatory intracellular infection with Anaplasma phagocytophilum
    Yasuko Rikihisa
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Clin Microbiol Rev 24:469-89. 2011
  9. pmc Detection and identification of Ehrlichia, Borrelia burgdorferi sensu lato, and Bartonella species in Dutch Ixodes ricinus ticks
    L M Schouls
    Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Clin Microbiol 37:2215-22. 1999
  10. pmc Wild boars as hosts of human-pathogenic Anaplasma phagocytophilum variants
    Jerzy Michalik
    Department of Animal Morphology, Faculty of Biology, Adam Mickiewicz University, Poznan, Poland
    Emerg Infect Dis 18:998-1001. 2012

Detail Information

Publications272 found, 100 shown here

  1. pmc Human ehrlichiosis and anaplasmosis
    Nahed Ismail
    Department of Pathology, Meharry Medical College, Nashville, TN 37208, USA
    Clin Lab Med 30:261-92. 2010
    Human ehrlichiosis and anaplasmosis are acute febrile tick-borne diseases caused by various members of the genera Ehrlichia and Anaplasma (Anaplasmataceae)...
  2. ncbi The natural history of Anaplasma phagocytophilum
    Zerai Woldehiwet
    University of Liverpool, Department of Veterinary Pathology, Veterinary Teaching Hospital, Leahurst, Neston, South Wirral CH64 7TE, UK
    Vet Parasitol 167:108-22. 2010
    ..species of granulocytic bacteria, Ehrlichia phagocytophila, Ehrlichia equi and the agent of human granulocytic ehrlichiosis, after the recent reorganization of the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales...
  3. pmc Delineating Anaplasma phagocytophilum ecotypes in coexisting, discrete enzootic cycles
    Kevin J Bown
    University of Liverpool, Liverpool, UK
    Emerg Infect Dis 15:1948-54. 2009
    ..phagocytophilum are restricted to coexisting but separate enzootic cycles and suggest that this restriction may result from specific vector compatibility...
  4. pmc Distinct host species correlate with Anaplasma phagocytophilum ankA gene clusters
    Wiebke Scharf
    Institute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    J Clin Microbiol 49:790-6. 2011
    ..Whereas the phylogenetic analysis using 16S rRNA gene sequences was not meaningful, we showed that distinct host species correlate with A. phagocytophilum ankA gene clusters...
  5. pmc Ehrlichia chaffeensis and Anaplasma phagocytophilum lack genes for lipid A biosynthesis and incorporate cholesterol for their survival
    Mingqun Lin
    Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA
    Infect Immun 71:5324-31. 2003
    ..Taken together, these results suggest that human ehrlichiosis agents became cholesterol dependent due to the loss of these genes...
  6. ncbi Nosocomial transmission of human granulocytic anaplasmosis in China
    Lijuan Zhang
    National Institute of Communicable Disease Control and Prevention, China, CDC, Beijing, China, PO Box 5, Changping, Beijing, China 102206
    JAMA 300:2263-70. 2008
    ..A cluster of cases among health care workers and family members following exposure to a patient with fulminant disease consistent with HGA prompted investigation...
  7. ncbi Anaplasma phagocytophilum AnkA secreted by type IV secretion system is tyrosine phosphorylated by Abl-1 to facilitate infection
    Mingqun Lin
    Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
    Cell Microbiol 9:2644-57. 2007
    ....
  8. pmc Mechanisms of obligatory intracellular infection with Anaplasma phagocytophilum
    Yasuko Rikihisa
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Clin Microbiol Rev 24:469-89. 2011
    ..An understanding of the molecular mechanisms underlying A. phagocytophilum infection will foster the development of creative ideas to prevent or treat this emerging tick-borne disease...
  9. pmc Detection and identification of Ehrlichia, Borrelia burgdorferi sensu lato, and Bartonella species in Dutch Ixodes ricinus ticks
    L M Schouls
    Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Clin Microbiol 37:2215-22. 1999
    ..phagocytophila and the human granulocytic ehrlichiosis agent. The majority of the other positive ticks were infected with a newly identified Ehrlichia-like species...
  10. pmc Wild boars as hosts of human-pathogenic Anaplasma phagocytophilum variants
    Jerzy Michalik
    Department of Animal Morphology, Faculty of Biology, Adam Mickiewicz University, Poznan, Poland
    Emerg Infect Dis 18:998-1001. 2012
    ..phagocytophilum variants, including a predominance of strains known to cause human disease. Boars are thus hosts for A. phagocytophilum, notably, strains associated with human granulocytic anaplasmosis...
  11. ncbi Anaplasma phagocytophilum in livestock and small rodents
    Lin Zhan
    State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 20 Dong Da Street, Fengtai District, Beijing 100071, People s Republic of China
    Vet Microbiol 144:405-8. 2010
    ..phagocytophilum in rodents might be able to infect livestock and intensified the threats of anaplasmosis to livestock in the area. Further studies on public health significance of the agent are worth investigation in future...
  12. ncbi Anaplasma phagocytophilum variants in sympatric red deer (Cervus elaphus) and sheep in southern Norway
    Snorre Stuen
    Norwegian School of Veterinary Science, Department of Production Animal Clinical Sciences, Sandnes, Norway
    Ticks Tick Borne Dis 4:197-201. 2013
    ....
  13. pmc Ehrlichia chaffeensis: a prototypical emerging pathogen
    Christopher D Paddock
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Microbiol Rev 16:37-64. 2003
    ..features, and laboratory diagnosis of the zoonotic disease it causes (commonly referred to as human monocytic ehrlichiosis [HME]) has expanded considerably in the period since its discovery...
  14. pmc Anaplasma phagocytophilum outer membrane protein A interacts with sialylated glycoproteins to promote infection of mammalian host cells
    Nore Ojogun
    Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
    Infect Immun 80:3748-60. 2012
    ..Therefore, OmpA interacts with sialylated glycoproteins. This study identifies the first A. phagocytophilum adhesin-receptor pair and delineates the region of OmpA that is critical for infection...
  15. ncbi The ascendancy of Amblyomma americanum as a vector of pathogens affecting humans in the United States
    James E Childs
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Annu Rev Entomol 48:307-37. 2003
    ....
  16. pmc Invasion and intracellular development of the human granulocytic ehrlichiosis agent in tick cell culture
    U G Munderloh
    Department of Entomology, University of Minnesota, St Paul, Minnesota 55108, USA
    J Clin Microbiol 37:2518-24. 1999
    ..ehrlichias are tick-borne bacterial pathogens that cause an acute, life-threatening illness, human granulocytic ehrlichiosis (HGE)...
  17. ncbi Molecular detection of Anaplasma phagocytophilum in the European hedgehog (Erinaceus europaeus) and its ticks
    Jasmin Skuballa
    Department of Ecology and Parasitology, Zoological Institute, Karlsruhe Institute of Technology, Karlsruhe, Germany
    Vector Borne Zoonotic Dis 10:1055-7. 2010
    ..Thus, this species may play a role in human contact with zoonotic diseases. Here we report the presence of the pathogen Anaplasma phagocytophilum in hedgehogs and their ticks in Germany...
  18. ncbi Ehrlichiosis and anaplasmosis in dogs and cats
    Susan E Little
    Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078 2007, USA
    Vet Clin North Am Small Anim Pract 40:1121-40. 2010
    In the time since canine ehrlichiosis due to Ehrlichia canis was first described in 1935 and first recognized in the United States in 1962, many key advances have been made in our understanding of the diversity of the rickettsial ..
  19. pmc Identification of a granulocytotropic Ehrlichia species as the etiologic agent of human disease
    S M Chen
    Department of Pathology, University of Texas Medical Branch, Galveston 77555
    J Clin Microbiol 32:589-95. 1994
    ..chaffeensis DNA, and E. chaffeensis-specific primers did not amplify DNAs of the human granulocytic ehrlichia. Thus, six patients were shown to be infected by an Ehrlichia species never previously reported to infect humans...
  20. pmc Sequence analysis of the ank gene of granulocytic ehrlichiae
    R F Massung
    Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 38:2917-22. 2000
    The ank gene of the agent of human granulocytic ehrlichiosis (HGE) codes for a protein with a predicted molecular size of 131.2 kDa that is recognized by serum from both dogs and humans infected with granulocytic ehrlichiae...
  21. pmc Ehrlichiosis, babesiosis, anaplasmosis and hepatozoonosis in dogs from St. Kitts, West Indies
    Patrick J Kelly
    Ross University School of Veterinary Medicine, St Kitts, West Indies
    PLoS ONE 8:e53450. 2013
    ..Although tick-borne diseases are important causes of morbidity and mortality in dogs in tropical areas, there is little information on the agents causing these infections in the Caribbean...
  22. pmc Multiplex detection of Ehrlichia and Anaplasma species pathogens in peripheral blood by real-time reverse transcriptase-polymerase chain reaction
    Kamesh R Sirigireddy
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, 1800 Denison Ave, Manhattan, Kansas 66506, USA
    J Mol Diagn 7:308-16. 2005
    ..The test was assessed by examining blood samples from dogs suspected to be positive for ehrlichiosis. The dog was chosen as the model system because it is susceptible to acquire infections with up to five ..
  23. pmc Emergence of the ehrlichioses as human health problems
    D H Walker
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
    Emerg Infect Dis 2:18-29. 1996
    ..Likewise, approximately 170 cases of human granulocytic ehrlichiosis have been diagnosed, most since 1994, predominantly in the upper midwestern and northeastern states, but also ..
  24. pmc Isolation of the equine granulocytic ehrlichiosis agent, Ehrlichia equi, in tick cell culture
    U G Munderloh
    Department of Entomology, University of Minnesota, St Paul 55108, USA
    J Clin Microbiol 34:664-70. 1996
    The equine granulocytic ehrlichiosis agent, Ehrlichia equi, is closely related or identical to the human granulocytic ehrlichiosis (HGE) agent. Both are suspected of being transmitted by ticks. We have successfully isolated E...
  25. ncbi Detection of Borrelia burgdorferi, Ehrlichia chaffeensis, and Anaplasma phagocytophilum in ticks (Acari: Ixodidae) from a coastal region of California
    Kevin Holden
    Department of Biological Sciences, San Jose State University, San Jose, CA 95192, USA
    J Med Entomol 40:534-9. 2003
    ..prevalence and distribution of the agents of Lyme disease, human granulocytic (HGE), and human monocytic (HME) ehrlichiosis in 1,187 adult ixodid ticks collected from eight public-use recreation areas over a 2-yr period...
  26. ncbi Anaplasma phagocytophilum and Ehrlichia chaffeensis: subversive manipulators of host cells
    Yasuko Rikihisa
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, Ohio 43210, USA
    Nat Rev Microbiol 8:328-39. 2010
    ..Here, I review the specialized properties and other adaptations of these intracellular bacteria...
  27. pmc ankA: an Ehrlichia phagocytophila group gene encoding a cytoplasmic protein antigen with ankyrin repeats
    P Caturegli
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 68:5277-83. 2000
    Human granulocytic ehrlichiosis (HGE) is a potentially fatal, tick-borne disease caused by a bacterium related or identical to Ehrlichia phagocytophila. To identify and characterize E...
  28. ncbi Diagnosis of canine monocytotropic ehrlichiosis (Ehrlichia canis): an overview
    Shimon Harrus
    Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel
    Vet J 187:292-6. 2011
    Canine monocytotropic ehrlichiosis (CME), caused by the rickettsia Ehrlichia canis, an important canine disease with a worldwide distribution...
  29. ncbi The risk of exposure to Anaplasma phagocytophilum infection in Mid-Eastern Poland
    Krzysztof Tomasiewicz
    Department of Infectious Diseases, Medical University of Lublin, Biernackiego 9, 20 089 Lublin, Poland
    Ann Agric Environ Med 11:261-4. 2004
    ..phagocytophilum in the natural environment of Mid-Eastern Poland. As the risk for infection exists, it should call the attention of public health services to the possibility of an increasing number of patients with this disease...
  30. pmc Identity of ehrlichial DNA sequences derived from Ixodes ricinus ticks with those obtained from patients with human granulocytic ehrlichiosis in Slovenia
    M Petrovec
    Institute of Microbiology and Immunology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia
    J Clin Microbiol 37:209-10. 1999
    ..Acari: Ixodidae) ticks collected near Ljubljana, Slovenia, were tested for the agent of human granulocytic ehrlichiosis (HGE) by using PCR assays based on the 16S rRNA gene. Three (3...
  31. ncbi Infections with Anaplasma phagocytophilum in dogs in Germany
    B Kohn
    Small Animal Clinic, Faculty of Veterinary Medicine, Freie Universitat Berlin, Berlin, Germany
    Res Vet Sci 91:71-6. 2011
    ..The CBC was within reference range in 10 PCR-positive clinically healthy dogs suggesting a routine examination of blood donors for A. phagocytophilum in endemic areas to minimize the risk of transmission...
  32. ncbi Emerging and re-emerging tick-transmitted rickettsial and ehrlichial infections
    David H Walker
    Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0609, USA
    Med Clin North Am 92:1345-61, x. 2008
    ..Globally, many of these bacteria have been named but the genetic differences among them are often small, and many of their clinical manifestations may not be distinguishable diagnostically...
  33. ncbi Serological and molecular prevalence of Borrelia burgdorferi, Anaplasma phagocytophilum, and Ehrlichia species in dogs from Minnesota
    Melissa J Beall
    IDEXX Laboratories, Inc, Westbrook, Maine, USA
    Vector Borne Zoonotic Dis 8:455-64. 2008
    ..Based on PCR testing, A. phagocytophilum DNA was more prevalent in suspected cases of anaplasmosis or borreliosis than in healthy dogs from the same region...
  34. ncbi Cultivation of an ovine strain of Ehrlichia phagocytophila in tick cell cultures
    Z Woldehiwet
    Department of Veterinary Pathology, University of Liverpool, PO Box 147, Liverpool, L69 3BX, UK
    J Comp Pathol 127:142-9. 2002
    ..phagocytophila. A susceptible sheep inoculated with a third passage of the tick cell-adapted E. phagocytophila reacted with fever and rickettsiaemia 5 days later, thus satisfying Koch's postulates...
  35. ncbi Sympatric Ixodes trianguliceps and Ixodes ricinus ticks feeding on field voles (Microtus agrestis): potential for increased risk of Anaplasma phagocytophilum in the United Kingdom?
    K J Bown
    Department of Veterinary Pathology, University of Liverpool, Liverpool, UK
    Vector Borne Zoonotic Dis 6:404-10. 2006
    ..trianguliceps, which may alone maintain endemic cycles, and exophilic I. ricinus ticks, which could act as a bridge vector and transmit infections to humans and domesticated animals...
  36. pmc Reservoir competency of goats for the Ap-variant 1 strain of Anaplasma phagocytophilum
    Robert F Massung
    Centers for Disease Control and Prevention, 1600 Clifton Rd, MS G 13, Atlanta, GA 30333, USA
    Infect Immun 74:1373-5. 2006
    ..Goats were shown to be competent as a reservoir for Ap-Variant 1, and challenge and immunosuppression studies were used to further examine infection in the goat model...
  37. pmc Isolation and characterization of Ehrlichia chaffeensis strains from patients with fatal ehrlichiosis
    C D Paddock
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 35:2496-502. 1997
    ..chaffeensis...
  38. ncbi Infections of wild animals with Anaplasma phagocytophila in Austria and the Czech Republic
    Miroslav Petrovec
    Institute of Microbiology and Immunology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia
    Ann N Y Acad Sci 990:103-6. 2003
  39. ncbi The European hedgehog (Erinaceus europaeus)--a suitable reservoir for variants of Anaplasma phagocytophilum?
    Cornelia Silaghi
    Comparative Tropical Medicine and Parasitology, Faculty of Veterinary Medicine, Ludwig Maximilians University, Munich, Germany
    Ticks Tick Borne Dis 3:49-54. 2012
    ..phagocytophilum and the simultaneous infestation with 2 tick species of all developmental stages suggest that the hedgehog may be a suitable reservoir for at least some variants of A. phagocytophilum...
  40. pmc The biological basis of severe outcomes in Anaplasma phagocytophilum infection
    J Stephen Dumler
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    FEMS Immunol Med Microbiol 64:13-20. 2012
    ..Whether severity relates to microbial factors or genetically determined diversity in human immune and inflammatory response needs more investigation...
  41. ncbi A molecular and serologic survey of Ehrlichia canis, E. chaffeensis, and E. ewingii in dogs and ticks from Oklahoma
    G L Murphy
    Department of Anatomy, Pathology, and Pharmacology, College of Veterinary Medicine, Oklahoma State University, Stillwater 74078, USA
    Vet Parasitol 79:325-39. 1998
    ..sanguineus. Results suggest that Ehrlichia spp. which are canine and human pathogens circulate in dogs in Oklahoma and in several tick species that feed on dogs...
  42. pmc Anaplasma phagocytophilum in horses and ticks in Tunisia
    Youmna M'Ghirbi
    Laboratoire d épidémiologie et microbiologie vétérinaire, Service d Entomologie Médicale, Institut Pasteur de Tunis, Tunis 1002, Tunisia
    Parasit Vectors 5:180. 2012
    ..We used direct and indirect methods to compare and evaluate exposure to A. phagocytophilum in horses in northern Tunisia...
  43. ncbi Genetic variability of Anaplasma phagocytophilum in Ixodes persulcatus ticks and small mammals in the Asian part of Russia
    Vera A Rar
    Institute of Chemical Biology and Fundamental Medicine, Russian Academy of Sciences, Novosibirsk, Russian Federation
    Vector Borne Zoonotic Dis 11:1013-21. 2011
    ..phagocytophilum strains from roe deer (Capreolus capreolus) and Ixodes ricinus ticks...
  44. pmc Comparison of the nucleotide sequences of 16S rRNA, 444 Ep-ank, and groESL heat shock operon genes in naturally occurring Ehrlichia equi and human granulocytic ehrlichiosis agent isolates from Northern California
    J S Chae
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    J Clin Microbiol 38:1364-9. 2000
    We examined 11 naturally occurring isolates of Ehrlichia equi in horses and two human granulocytic ehrlichiosis agent isolates in California for sequence diversity in three genes...
  45. ncbi Genetic variants of Anaplasma phagocytophilum in wild caprine and cervid ungulates from the Alps in Tyrol, Austria
    Cornelia Silaghi
    Faculty of Veterinary Medicine and Parasitology, Institute of Comparative Tropical Medicine and Parasitology, Ludwig Maximilians University, Leopoldstrasse 5, Munich, Germany
    Vector Borne Zoonotic Dis 11:355-62. 2011
    ..phagocytophilum. The pathogenicity of the variants and the reservoir competence of the species investigated in this study deserve further attention in future studies...
  46. pmc Infection with agents of human granulocytic ehrlichiosis, lyme disease, and babesiosis in wild white-footed mice (Peromyscus leucopus) in Connecticut
    K C Stafford
    The Connecticut Agricultural Experiment Station, New Haven, Connecticut 06504, USA
    J Clin Microbiol 37:2887-92. 1999
    ..In nested PCR tests using the 16S rRNA gene, the DNA of the human granulocytic ehrlichiosis (HGE) agent was detected in 17 of 47 mice (36.2%), but only 4 (23...
  47. pmc Efficacy of a doxycycline treatment regimen initiated during three different phases of experimental ehrlichiosis
    Jennifer C McClure
    Department of Veterinary Pathobiology, University of Missouri, 210 Connaway Hall, Columbia, Missouri 65211, USA
    Antimicrob Agents Chemother 54:5012-20. 2010
    Doxycycline is the treatment of choice for canine monocytic ehrlichiosis (CME), a well-characterized disease and valuable model for tick-borne zoonoses...
  48. pmc Postgenomic analyses reveal development of infectious Anaplasma phagocytophilum during transmission from ticks to mice
    Juliana E Mastronunzio
    Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA
    J Bacteriol 194:2238-47. 2012
    ..phagocytophilum during transmission from ticks to mammals and demonstrates that the abundantly expressed, DC-associated APH_1235 protein is important during in vivo infection by A. phagocytophilum...
  49. pmc Comparison of simultaneous splenic sample PCR with blood sample PCR for diagnosis and treatment of experimental Ehrlichia canis infection
    Shimon Harrus
    School of Veterinary Medicine, Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Antimicrob Agents Chemother 48:4488-90. 2004
    This report presents evidence that dogs recover from acute canine monocytic ehrlichiosis (CME) after 16 days of doxycycline treatment (10 mg/kg of body weight every 24 h)...
  50. ncbi Prevalence of Anaplasma phagocytophilum and coinfection with Borrelia burgdorferi sensu lato in the hard tick Ixodes ricinus in the city of Hanover (Germany)
    Sabine Schicht
    Institute for Parasitology, University of Veterinary Medicine Hannover, Hannover, Germany
    Vector Borne Zoonotic Dis 11:1595-7. 2011
    ..Coinfections with B. burgdorferi sl were found in 0.9% of all tick stages. The detected genospecies were B. afzelii, B. garinii, B. burgdorferi sensu stricto (ss), and B. garinii, which was the most frequent species in coinfected ticks...
  51. ncbi Investigation of Anaplasma phagocytophila infections in Ixodes ricinus and Dermacentor reticulatus ticks in Austria
    Wolfdieter Sixl
    Institute of Hygiene, University of Graz, Graz, Austria
    Ann N Y Acad Sci 990:94-7. 2003
  52. pmc Persistent Ehrlichia chaffeensis infection occurs in the absence of functional major histocompatibility complex class II genes
    Roman Reddy Ganta
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506, USA
    Infect Immun 70:380-8. 2002
    Human monocytic ehrlichiosis is an emerging tick-borne disease caused by the rickettsia Ehrlichia chaffeensis. We investigated the impact of two genes that control macrophage and T-cell function on murine resistance to E. chaffeensis...
  53. pmc Exit mechanisms of the intracellular bacterium Ehrlichia
    Sunil Thomas
    Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 5:e15775. 2010
    ..Ehrlichia chaffeensis that resides in mononuclear phagocytes is the causative agent of human monocytotropic ehrlichiosis. Ehrlichia muris and Ixodes ovatus Ehrlichia (IOE) are agents of mouse models of ehrlichiosis...
  54. pmc Type IV secretion in the obligatory intracellular bacterium Anaplasma phagocytophilum
    Yasuko Rikihisa
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Cell Microbiol 12:1213-21. 2010
    ..At the cellular level, the two effectors have distinct subcellular localization and signalling in host cells. Thus in this obligatory intracellular pathogen, the T4S system has evolved as a host-subversive survival factor...
  55. pmc Anaplasma phagocytophilum in white-tailed deer
    Robert F Massung
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 11:1604-6. 2005
    ..These results will affect surveillance studies of vector and reservoir populations...
  56. pmc Emergence of a new pathogenic Ehrlichia species, Wisconsin and Minnesota, 2009
    Bobbi S Pritt
    Mayo Clinic, Division of Clinical Microbiology, Hilton 470 B, 200 1st St SW, Rochester, MN 55905, USA
    N Engl J Med 365:422-9. 2011
    b>Ehrlichiosis is a clinically important, emerging zoonosis. Only Ehrlichia chaffeensis and E. ewingii have been thought to cause ehrlichiosis in humans in the United States...
  57. pmc Rickettsial Seroepidemiology among farm workers, Tianjin, People's Republic of China
    Lijuan Zhang
    National Institute of Communicable Disease Control and Prevention, Beijing, People s Republic of China
    Emerg Infect Dis 14:938-40. 2008
    ..Demographic features of seropositive persons suggest distinct epidemiology, ecology, and risks...
  58. pmc Equine and canine Anaplasma phagocytophilum strains isolated on the island of Sardinia (Italy) are phylogenetically related to pathogenic strains from the United States
    Alberto Alberti
    Istituto di Patologia Speciale e Clinica Medica Veterinaria, Universita degli Studi di Sassari, Via Vienna 2, 07100 Sassari, Italy
    Appl Environ Microbiol 71:6418-22. 2005
    ..Phylogenetic analysis revealed that Sardinian strains are genetically distinct from the two lineages previously described in Europe and are closely related to strains isolated in different areas of the United States...
  59. pmc Ehrlichia-infected ticks on migrating birds
    A Bjoersdorff
    Kalmar County Hospital, Sweden
    Emerg Infect Dis 7:877-9. 2001
    ..gene sequences found in ticks collected from these migrating birds were identical to those of granulocytic ehrlichiosis found in domestic animals and humans in Sweden...
  60. ncbi Infection with Anaplasma phagocytophila in cervids from Slovenia: evidence of two genotypic lineages
    Miroslav Petrovec
    Institute of Microbiology and Immunology, Medical Faculty, University of Ljubljana, Slovenia
    Wien Klin Wochenschr 114:641-7. 2002
    Human granulocytic ehrlichiosis (HGE) was recently recognized as an emerging tick-borne infection in Europe. The disease is caused by Anaplasma (previously Ehrlichia) phagocytophila. The first confirmed acute human disease caused by A...
  61. pmc PCR detection of granulocytic ehrlichiae in Ixodes ricinus ticks and wild small mammals in western Switzerland
    J S Liz
    Department of Immunology, Institute of Zoology, University of Neuchatel, 2007 Neuchatel, Switzerland
    J Clin Microbiol 38:1002-7. 2000
    ..by PCR in Ixodes ricinus ticks and wild small mammals in Switzerland in two areas of endemicity for bovine ehrlichiosis. Six ticks (three females and three nymphs) (1.4%) of 417 I...
  62. ncbi Effect of tick removal on transmission of Borrelia burgdorferi and Ehrlichia phagocytophila by Ixodes scapularis nymphs
    F des Vignes
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06520-0834, USA
    J Infect Dis 183:773-8. 2001
    ..spirochete Borrelia burgdorferi and field strains of Ehrlichia phagocytophila, an agent of human granulocytic ehrlichiosis. Infected nymphal Ixodes scapularis were allowed to feed individually on mice, and equal numbers were removed ..
  63. pmc Relative importance of Ixodes ricinus and Ixodes trianguliceps as vectors for Anaplasma phagocytophilum and Babesia microti in field vole (Microtus agrestis) populations
    K J Bown
    Department of Veterinary Pathology, University of Liverpool, Neston, Cheshire, United Kingdom
    Appl Environ Microbiol 74:7118-25. 2008
    ..This study provides compelling evidence for the importance of I. trianguliceps in maintaining these enzootic tick-borne infections, while highlighting the potential for such infections to escape into alternative hosts via I. ricinus...
  64. pmc Comparative genomics of emerging human ehrlichiosis agents
    Julie C Dunning Hotopp
    The Institute for Genomic Research, Rockville, Maryland, USA
    PLoS Genet 2:e21. 2006
    ..and Neorickettsia (formerly Ehrlichia) sennetsu are intracellular vector-borne pathogens that cause human ehrlichiosis, an emerging infectious disease...
  65. ncbi Human infection with Ehrlichia canis accompanied by clinical signs in Venezuela
    Miriam Perez
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210 1093, USA
    Ann N Y Acad Sci 1078:110-7. 2006
    A total of 20 human patients with clinical signs compatible with human monocytic ehrlichiosis (HME), who were admitted to the emergency clinic in Lara State, Venezuela, were studied...
  66. ncbi Assessment of feline ehrlichiosis in central Spain using serology and a polymerase chain reaction technique
    Enara Aguirre
    Collefe of Veterinary Medicine, Universidad Complutense de Madrid, Spain
    Ann N Y Acad Sci 1026:103-5. 2004
    ..Our results demonstrate reactivity against agents implicated in feline ehrlichiosis in Spain...
  67. ncbi Longitudinal quantification of Ehrlichia canis in experimental infection with comparison to natural infection
    Gad Baneth
    School of Veterinary Medicine, Hebrew University, Rehovot 76100, Israel
    Vet Microbiol 136:321-5. 2009
    ..All EI dogs were positive for E. canis DNA by 7d PI and developed clinical ehrlichiosis by 9-12d PI...
  68. ncbi Ehrlichiosis in Brazil
    Rafael Felipe da Costa Vieira
    Departamento de Medicina Veterinaria Preventiva, Universidade Estadual de Londrina, Londrina, PR, Brazil
    Rev Bras Parasitol Vet 20:1-12. 2011
    b>Ehrlichiosis is a disease caused by rickettsial organisms belonging to the genus Ehrlichia. In Brazil, molecular and serological studies have evaluated the occurrence of Ehrlichia species in dogs, cats, wild animals and humans...
  69. ncbi Canine ehrlichioses: an update
    P J Kelly
    Biomedical Research and Training Institute, Harare, Zimbabwe
    J S Afr Vet Assoc 71:77-86. 2000
    ....
  70. pmc Structure-based vaccines provide protection in a mouse model of ehrlichiosis
    Sunil Thomas
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 6:e27981. 2011
    ..The obligately intracellular gram negative bacteria Ehrlichia cause ehrlichioses in humans and animals. As yet there are no vaccines to protect against Ehrlichia infection...
  71. ncbi Evaluation of an indirect enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies against Anaplasma phagocytophilum in sheep
    Z Woldehiwet
    Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool, Leahurst Campus, Neston, Wirral CH64 7TE, UK
    J Comp Pathol 146:116-21. 2012
    ..8% and a specificity of 95.7%. Lowering the cut-off point to 15PP increased the sensitivity to 94.6%, but reduced the specificity to 92.8%...
  72. pmc Anaplasma phagocytophilum-infected ticks, Japan
    Norio Ohashi
    Laboratory of Experimental Microbiology, Institute for Environmental Sciences, University of Shizuoka, 52 1 Yada, Suruga, Shizuoka 422 8526, Japan
    Emerg Infect Dis 11:1780-3. 2005
    ..Unique p44/msp2 paralogs (and/or 16S rRNA genes) were detected in tick tissues, salivary glands, and spleens of experimentally infected mice. These findings indicate the public health threat of anaplasmosis in Japan...
  73. ncbi Wild and farm breeding cervids infections with Anaplasma phagocytophilum
    Joanna Hapunik
    W Stefanski Institute of Parasitology of the Polish Academy of Sciences, Warsaw, Poland
    Ann Agric Environ Med 18:73-7. 2011
    ..9 percent, 38.7 percent, 34.37 percent of infected animals, respectively. The lowest rate of infection was found in fallow deer (Dama dama) - ony 1.5 percent...
  74. pmc The interaction between IL-18 and IL-18 receptor limits the magnitude of protective immunity and enhances pathogenic responses following infection with intracellular bacteria
    Purnima Ghose
    Department of Pathology, Meharry Medical College, Nashville, TN 37028, USA
    J Immunol 187:1333-46. 2011
    ..Together, these results suggested that the presence or absence of IL-18R signals governs the pathogenic versus protective immunity in a model of Ehrlichia-induced immunopathology...
  75. ncbi Ixodes ricinus as a vector of Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum and Babesia microti in urban and suburban forests
    Joanna Stanczak
    Medical University of Gdansk, Interfaculty Institute of Maritime and Tropical Medicine, 9B Powstania Styczniowego str, 81 519 Gdynia, Poland
    Ann Agric Environ Med 11:109-14. 2004
    ..3 %). Among adult ticks (n = 303), 8.3 % were dually infected with A. phagocytophilum and B. burgdorferi s.l., 2.0 % with the agent of human anaplasmosis and B. microti and 0.3 % with borreliae and B. microti...
  76. ncbi Prevalence of Anaplasma phagocytophilum and its coinfection with Borrelia afzelii in Ixodes ricinus and Ixodes persulcatus ticks inhabiting Tver Province (Russia) - a sympatric region for both tick species
    Toshiyuki Masuzawa
    Laboratory of Microbiology and Immunology, Faculty of Pharmacy, Chiba Institute of Science CIS, Choshi 288 0025, Japan
    J Med Microbiol 57:986-91. 2008
    ..phagocytophilum strains to specific vector ticks or reservoir hosts in different countries and areas. These findings suggest that there is a public health threat from HGA and LB in Tver Province surrounding Moscow...
  77. pmc Agents of human anaplasmosis and Lyme disease at Camp Ripley, Minnesota
    RUSSELL C JOHNSON
    University of Minnesota, Department of Microbiology, Minneapolis, Minnesota 55455, USA
    Vector Borne Zoonotic Dis 11:1529-34. 2011
    ..Antibodies to Bb were detected in >80% of the deer, but Bb DNA was only detected in 1.5% of blood specimens...
  78. ncbi Canine ehrlichiosis
    Bogumila Skotarczak
    Department of Genetics, Faculty of Biology, Szczecin University, Piastow 40B, 71 065 Szczecin, Poland
    Ann Agric Environ Med 10:137-41. 2003
    ..The agent causing canine granulocytic ehrlichiosis (CGE) in Europe has been determined by nucleotide sequencing of the 16S rRNA gene to be similar to both ..
  79. ncbi Human Granulocytic Ehrlichiosis in Belgium: an underestimated cause of disease
    P Heyman
    Research Laboratory for Vector Borne Diseases, Queen Astrid Military Hospital, Bruynstraat 1, Brussels B 1120, Belgium
    J Infect 47:129-32. 2003
    Human Granulocytic Ehrlichiosis (HGE) is a recently discovered zoonosis and, in Europe, not always included in laboratory testing when a patient presents with a history of tick bite...
  80. pmc Correlation between tick density and pathogen endemicity, New Hampshire
    Seth T Walk
    University of Massachusetts, Amherst, Massachusetts, USA
    Emerg Infect Dis 15:585-7. 2009
    ..Pathogens were more prevalent in areas of high tick density, suggesting a correlation between tick establishment and pathogen endemicity. Infection rates in ticks correlated with disease frequency in humans...
  81. ncbi Significance of serological testing for ehrlichial diseases in dogs with special emphasis on the diagnosis of canine monocytic ehrlichiosis caused by Ehrlichia canis
    T Waner
    Israel Institute for Biological Research, P O Box 19, Ness Ziona 70400, Israel
    Vet Parasitol 95:1-15. 2001
    Dogs are susceptible to a number of ehrlichial diseases. Among them, canine monocytic ehrlichiosis is an important and potentially fatal disease of dogs caused by the rickettsia Ehrlichia canis...
  82. pmc Anaplasma phagocytophilum increases cathepsin L activity, thereby globally influencing neutrophil function
    Venetta Thomas
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8031, USA
    Infect Immun 76:4905-12. 2008
    ..As therapeutic options for A. phagocytophilum and related organisms are limited, these results also identify a cellular pathway that may be targeted for the treatment of A. phagocytophilum infection...
  83. pmc Regulatory roles of CD1d-restricted NKT cells in the induction of toxic shock-like syndrome in an animal model of fatal ehrlichiosis
    H L Stevenson
    Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555 0609, USA
    Infect Immun 76:1434-44. 2008
    ..Using a murine model of fatal ehrlichiosis, we investigated the role of CD1d-restricted NKT cells in induction of toxic shock-like syndrome caused by gram-..
  84. ncbi Clinical, serological, and molecular evidence of ehrlichiosis and anaplasmosis in dogs in Tunisia
    Y M'Ghirbi
    Service d Entomologie Médicale, Institut Pasteur de Tunis, 1002 Tunis, Tunisia
    Parasitol Res 104:767-74. 2009
    ..to Ehrlichia canis and Anaplasma phagocytophilum antigens, surrogate markers of the agents of canine monocytic ehrlichiosis (CME) and canine granulocytic ehrlichiosis, respectively. Among 286 collected sera, 54.2% and 25...
  85. pmc Anaplasma phagocytophilum infection in small mammal hosts of Ixodes ticks, western United States
    Janet E Foley
    University of California, Davis, California, USA
    Emerg Infect Dis 14:1147-50. 2008
    ..High seroprevalence was observed in northern sites. Ten tick species were identified. Heavily infested rodent species included meadow voles, woodrats, deer mice, and redwood chipmunks...
  86. pmc Diminished adhesion of Anaplasma phagocytophilum-infected neutrophils to endothelial cells is associated with reduced expression of leukocyte surface selectin
    Kyoung Seong Choi
    Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Infect Immun 71:4586-94. 2003
    ..These observations may help us to understand the modified biological responses, host inflammation, and immune response that occur with A. phagocytophilum infections...
  87. ncbi Hepatic pathology in human monocytic ehrlichiosis. Ehrlichia chaffeensis infection
    Ann E Sehdev
    Dept of Pathology, Johns Hopkins Medical Institutions, Meyer B1 193, 600 N Wolfe St, Baltimore, MD 21287, USA
    Am J Clin Pathol 119:859-65. 2003
    Ehrlichia chaffeensis causes human monocytic ehrlichiosis (HME) that usually includes fever, myalgias, and pancytopenia and, in 80% to 90% of patients, elevations in serum transaminase levels...
  88. ncbi Comparative vector competence of Dermacentor variabilis and Ixodes scapularis (Acari: Ixodidae) for the agent of human granulocytic ehrlichiosis
    F des Vignes
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06520 8034, USA
    J Med Entomol 36:182-5. 1999
    Vector competence of Ixodes scapularis Say and Dermacentor variabilis Say for the agent of human granulocytic ehrlichiosis (HGE) was compared...
  89. ncbi A survey on Anaplasma phagocytophila in wild small mammals and roe deer (Capreolus capreolus) in Northern Spain
    Beatriz Oporto
    NEIKER, Departamento Sanidad Animal, Berreaga 1, 48160 Derio, Bizkaia, Spain
    Ann N Y Acad Sci 990:98-102. 2003
  90. pmc Relative importance of T-cell subsets in monocytotropic ehrlichiosis: a novel effector mechanism involved in Ehrlichia-induced immunopathology in murine ehrlichiosis
    Nahed Ismail
    Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, 301 University Blvd, Galveston, TX 77555 0609, USA
    Infect Immun 75:4608-20. 2007
    ..we investigated the role of CD4(+) and CD8(+) T cells in immunity to Ehrlichia and the pathogenesis of fatal ehrlichiosis caused by infection with low- and high-dose (10(3) and 10(5) bacterial genomes/mouse, respectively) ehrlichial ..
  91. ncbi Molecular evidence for Anaplasma phagocytophilum and Borrelia burgdorferi sensu lato in Ixodes ricinus ticks from eastern Slovakia
    Marketa Derdakova
    Faculty of Medicine, P J Safarik University, Srobarova 2, 041 80 Kosice, Slovak Republic
    Ann Agric Environ Med 10:269-71. 2003
    ..These results indicate that both B. burgdorferi s.l. and A. phagocytophilum co-circulate in the enzootic sites of Eastern Slovakia and may cause co-infection in humans...
  92. ncbi The relationship between the degree of thrombocytopenia and infection with Ehrlichia canis in an endemic area
    Camilo Bulla
    Clinical Pathology Laboratory, Departamento de Clínica Veterinária, Faculdade de Medicina Veterinaria e Zootecnia, Universidade Estadual Paulista, Botucatu, Brazil
    Vet Res 35:141-6. 2004
    Ehrlichia canis is the causative agent of canine monocytic ehrlichiosis. In order to evaluate platelet counts as a screening test for E...
  93. ncbi Anaplasma phagocytophilum seroprevalence in equids: a survey in Sicily (Italy)
    Elisabetta Giudice
    Dipartimento di Sanità Pubblica Veterinaria, Facolta di Medicina Veterinaria, Universita degli Studi di Messina, Polo Universitario dell Annunziata, 98168 Messina, Italy
    Parasitol Res 111:951-5. 2012
    ..However, further studies are necessary to elucidate the possible mechanisms that involve the Equidae as host of this pathogen...
  94. ncbi Prevalence of Borrelia burgdorferi s.l. and Anaplasma phagocytophilum in the wood tick Ixodes ricinus in the Province of Trento, Italy
    B Mantelli
    Centro di Ecologia Alpina, 38040, Viote del Monte Bondone, Trento, Italy
    Eur J Clin Microbiol Infect Dis 25:737-9. 2006
  95. ncbi Infection rates of Amblyomma americanum and Dermacentor variabilis by Ehrlichia chaffeensis and Ehrlichia ewingii in southwest Missouri
    John G Steiert
    Department of Biology, Southwest Missouri State University, Springfield, MO 65804, USA
    Vector Borne Zoonotic Dis 2:53-60. 2002
    Both Ehrlichia chaffeensis and Ehrlichia ewingii are causative agents of human ehrlichiosis. Both pathogens are transmitted to humans through the bite of an infected lone star tick (Amblyomma americanum)...
  96. pmc Hemocytic rickettsia-like organisms in ticks: serologic reactivity with antisera to Ehrlichiae and detection of DNA of agent of human granulocytic ehrlichiosis by PCR
    L A Magnarelli
    Department of Entomology, Connecticut Agricultural Experiment Station, New Haven 06504, USA
    J Clin Microbiol 33:2710-4. 1995
    ..canis and/or E. equi antisera, including sera from persons who had granulocytic ehrlichiosis. In separate PCR analyses, DNA of the agent of human granulocytic ehrlichiosis was detected in 59 (50...
  97. ncbi Evaluation of cytology in the diagnosis of acute canine monocytic ehrlichiosis (Ehrlichia canis): a comparison between five methods
    M E Mylonakis
    Clinic of Companion Animal Medicine, Faculty of Veterinary Medicine, School of Veterinary Medicine, Aristotles University of Thessaloniki, Thessaloniki, Greece
    Vet Microbiol 91:197-204. 2003
    ..that has been based on the detection of Ehrlichia canis morulae, in the acute phase of canine monocytic ehrlichiosis (CME). Their cellular localization, total numbers and microscopic differentials were also investigated...
  98. ncbi Ehrlichiosis and related infections
    Leah A Cohn
    College of Veterinary Medicine, University of Missouri Columbia, 379 East Campus, Clydesdale Hall, Columbia, MO 65211, USA
    Vet Clin North Am Small Anim Pract 33:863-84. 2003
    b>Ehrlichiosis is a term that has been used to describe infection with any of a number of related intracellular, vector-borne pathogens...
  99. ncbi Antibodies highly effective in SCID mice during infection by the intracellular bacterium Ehrlichia chaffeensis are of picomolar affinity and exhibit preferential epitope and isotype utilization
    Julia Shu Yi Li
    Department of Biomedical Sciences, School of Public Health, State University of New York, Albany, NY 12201, USA
    J Immunol 169:1419-25. 2002
    ..Thus, although epitope recognition and isotype use may contribute to efficacy, high affinity may be a critical characteristic of Abs that can act effectively during this intracellular bacterial infection...
  100. ncbi Outer membrane protein-specific monoclonal antibodies protect SCID mice from fatal infection by the obligate intracellular bacterial pathogen Ehrlichia chaffeensis
    J S Li
    Department of Biomedical Sciences, School of Public Health, State University of New York, Albany, NY 12201, USA
    J Immunol 166:1855-62. 2001
    ....
  101. pmc Diminished hematopoietic activity associated with alterations in innate and adaptive immunity in a mouse model of human monocytic ehrlichiosis
    Katherine C MacNamara
    New York State Department of Health, Wadsworth Center, Albany, New York 12201 2002, USA
    Infect Immun 77:4061-9. 2009
    Human monocytic ehrlichiosis (HME) is a tick-borne disease caused by Ehrlichia chaffeensis...

Research Grants65

  1. Tick Midgut Proteins Critical for Borrelia Transmission
    Sukanya Narasimhan; Fiscal Year: 2010
    ..transmit Borrelia burgdorferi (agent of Lyme disease), Anaplasma phagocytophilum (agent of human granulocytic ehrlichiosis) and Babesia microti (agent of human babesiosis) among other pathogens. A. phagocytophilum and B...
  2. Tick-Mammal Interface of Human Granulocytic Anaplasmosis
    ULRIKE GERTRUD MUNDERLOH; Fiscal Year: 2013
    ..Taken together, our research will continue to identify new leads on how to prevent and cure human anaplasmosis and similar diseases such as ehrlichiosis and spotted fevers.
  3. Tick feeding regulation by orthologous tick saliva serine protease inhibitors
    Albert Mulenga; Fiscal Year: 2013
    ..of major human tick borne diseases (TBD) in the United States, Lyme disease, human anaplasmosis, babesiosis and ehrlichiosis and the southern tick-associated rash illness (STARI) has been recognized...
  4. Development of a multivalent vaccine for mouse reservoirs of deer tick pathogens
    Linden T Hu; Fiscal Year: 2010
    ..S.-- Lyme disease, Babesiosis and human granulocytic ehrlichiosis. The incidence of all three diseases has been increasing over the last decade...
  5. TYPE IV SECRETION &SIGNAL TRANSDUCTION IN EHRLICHIOSIS
    Yasuko Rikihisa; Fiscal Year: 2013
    ..cause emerging potentially fatal infectious diseases human granulocytic anaplasmosis (HGA) and human monocytic ehrlichiosis (HME), respectively...
  6. Subverted host cell signaling by AnkA in Anaplasma phagocytophilum infection
    Jacob W IJdo; Fiscal Year: 2012
    Anaplasma phagocytophilum, is a human pathogen that infects neutrophils and causes Human Granulocytic Ehrlichiosis. In the Unites States it is the second most common tick-associated infection, only surpassed by Lyme disease...
  7. Identification of bacterial genes required for transmission of tick-borne pathoge
    Susan M Noh; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Tick-borne diseases, including anaplasmosis, ehrlichiosis, and several rickettsial diseases, remain poorly controlled amid increasing incidence...
  8. PEROMYSCUS LABORATORY MODELS FOR BIOMEDICAL RESEARCH
    Gabor Szalai; Fiscal Year: 2013
    ..PGSC has provided animals for investigators studying these and other diseases such as Ehrlichiosis, babesiosis and plaque...
  9. Interactions Between Anaplasma Phagocytophilum and Ixodes Scapularis
    Erol Fikrig; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Human granulocytic anaplasmosis (HGA), previously known as human granulocytic ehrlichiosis, is the second most common tick-borne illness in North America...
  10. Vector and Host Contributions to the Regulation of E. chaffeensis Gene Expression
    Roman R Ganta; Fiscal Year: 2012
    ..These illnesses include human monocytic ehrlichiosis, human granulocytic ehrlichiosis and human granulocytic anaplasmosis which are caused by Ehrlichia chaffeensis, ..
  11. Immunity to Ehrlichial Infections
    Nagaraja Ramavadhani Thirumalapura; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human monocytotropic ehrlichiosis (HME), caused by the obligately intracellular bacterium Ehrlichia chaffeensis, is an emerging, often life-threatening, tick-transmitted infectious disease in the ..
  12. Vector and Host Contributions to the Regulation of E. chaffeensis Gene Expression
    Roman R Ganta; Fiscal Year: 2013
    ..They include human monocytic ehrlichiosis caused by E. chaffeensis...
  13. 13th International Conference on Lyme Borreliosis and Other Tick-borne Diseases
    Linden T Hu; Fiscal Year: 2013
    ..The diseases included in this conference are Lyme borreliosis, babesiosis, human granulocytic anaplasmosis (ehrlichiosis) and tick-borne encephalitis...
  14. Pathogenic Role of NK Cells During Infection-Induced Toxic Shock
    Nahed Ismail; Fiscal Year: 2012
    ..Human monocytotropic ehrlichiosis (HME) is a highly prevalent life-threatening tick-borne disease in North America caused by E. chaffeensis...
  15. Vector-host-pathogen interface in monocytotropic ehrlichiosis
    David H Walker; Fiscal Year: 2013
    ..Although mechanisms of systemic immunity and immunopathogenesis to needle inoculated disseminated ehrlichiosis have been characterized, the early events in the cutaneous tick transmission site and draining lymph nodes have ..
  16. Ehrlichia Type-1 Secreted Effectors Exploit Host SUMO Pathways
    Jere W McBride; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Ehrlichia chaffeensis is the causative agent of human monocytotropic ehrlichiosis, the most prevalent life-threatening tick-borne zoonotic disease in the United States. E...
  17. MEHARRY RCMI PROGRAM IN WOMEN'S HEALTH RESEARCH
    Anna Cherrie Epps; Fiscal Year: 2013
    ..N. Ismail will study immune regulation of human monocytic ehrlichiosis during pregnancy...
  18. Coinfection of Tick-borne Diseases in Areas of Wisconsin
    DIANE CAPORALE; Fiscal Year: 2001
    ..applicant): Close to 400 human cases of Lyme disease and several --cases of Babesiosis and Human Granulocytic Ehrlichiosis (HGE) are reported in the State of Wisconsin each year...
  19. Spatially-explicit mathematical model of human monocytic ehrlichiosis
    HOLLY GAFF; Fiscal Year: 2010
    ..develop, analyze and apply a spatially-explicit mathematical model for the tick-borne disease, human monocytic ehrlichiosis (causitive agent: Ehrlichia chaffeensis sp.)...
  20. Landscape Ecology and Mapping of Ehrlichial Pathogens
    MICHAEL WIMBERLY; Fiscal Year: 2006
    ..Two of these diseases are human monocytotropic ehrlichiosis (HME), caused by Ehrlichia chaffeensis; and human granulocytic anaplasmosis (HGA) caused by Anaplasma ..
  21. Training in Parasitology and Vector Biology
    Christian Tschudi; Fiscal Year: 2013
    ..and vector perspective, including Malaria, African sleeping sickness, leishmaniasis, West Nile virus, human ehrlichiosis and Lyme disease...
  22. NOVEL ANTIGENS FOR THE SERODIAGNOSIS OF HUMAN BABESIOSIS
    Raymond Houghton; Fiscal Year: 2001
    ..g. Lyme disease and Human Granulocytic Ehrlichiosis. The estimated market for such a test should be similar to that for Lyme disease testing both in the U.S...
  23. MOLECULAR MECHANISMS OF MSP2 VARIATION IN RICKETTSIAE
    Anthony Barbet; Fiscal Year: 2007
    ..to improve our understanding of the mechanisms of pathogenesis of tick- borne rickettsial pathogens that cause ehrlichiosis and anaplasmosis of humans and animals. These pathogens efficiently utilize a small genome (<1...
  24. Genetic Determinants of Anaplasma Transmission
    SUSAN NOH; Fiscal Year: 2004
    ..within the genus Anaplasma (order Rickettsiales) cause human and animal diseases including human granulocytic ehrlichiosis (HGE), equine ehrlichiosis, and bovine and ovine anaplasmosis...
  25. HEALTH BURDERN OF COINFECTING DEER ASSOCIATED ZOONOSES
    Peter Krause; Fiscal Year: 2001
    ..Although we shall focus on the agents of Lyme disease, babesiosis, human granulocytic ehrlichiosis and TBE-group arboviruses, we shall seek to document the presence of other tick-borne microbes and the ..
  26. Antigenic variation of Anaplasma marginale
    PATRICK MEEUS; Fiscal Year: 2003
    ..pathogen, is closely related to Anaplasma (Ehrlichia) phagocytophila, the causative agent of human granulocytic ehrlichiosis. Investigations of bovine anaplasmosis offer a unique opportunity to study the mechanisms of antigenic ..
  27. TRANSMISSION OF GRANULOCYTIC EHRLICHIOSIS
    Sam Telford; Fiscal Year: 2000
    We propose to determine whether the agent of human granulocytic ehrlichiosis in coastal New England is cotransmitted with those of Lyme disease and human babesiosis...
  28. Prevention of Lyme Disease in Connecticut
    Matthew Cartter; Fiscal Year: 2007
    ..activities is to reduce the incidence of Lyme disease and other tick-borne diseases in including babesiosis and ehrlichiosis. This proposal will evaluate the effectiveness of the currently available measures to reduce the risk of LD in ..
  29. PATHOGENESIS OF HUMAN GRANULOCYTIC EHRLICHIOSIS
    Ulrike Munderloh; Fiscal Year: 2001
    DESCRIPTION (Adapted from the applicant's abstract): Human granulocytic ehrlichiosis (HGE) is an acute febrile illness described 2 years ago in Minnesota and Wisconsin and now rapidly emerging in areas infested by its likely vector, ..
  30. DEVELOPMENT OF PCR BASED ASSAY FOR BABESIOSIS
    BITA NAKHAI; Fiscal Year: 1999
    ..S. Although Lyme Disease is the most prevalent vector- borne disease, two additional diseases, Babesiosis and Ehrlichiosis are transmitted by the same tick vector and share the same host reservoir...
  31. Vaccination Against Ixodes scapularis Tick Bites
    Raymond Koski; Fiscal Year: 2001
    ..burgdorferi, the agent of human granulocytic ehrlichiosis, and Babesia microti...
  32. EHRLICHIA CHAFFEENSIS SURFACE PROTEINS
    David Walker; Fiscal Year: 2000
    ..mechanisms of protective immunity against Ehrlichia chaffeensis, the causative agent of human monocytotropic ehrlichiosis (HME)...
  33. Vaccination Against Ixodes scapularis Tick Bites
    Michel Ledizet; Fiscal Year: 2003
    ..burgdorferi. This tick also transmits the agents of human granulocytic ehrlichiosis and babesiosis. The purpose of this project is to develop an anti-I...
  34. TICK-BORNE DISEASE PANEL TEST
    Andrew Levin; Fiscal Year: 2000
    ..membrane immunoassay will simultaneously detect antibodies to the agents of Lyme disease, Human Granulocytic Ehrlichiosis, Human Monocytic Ehrlichiosis, Babesiosis, and Rocky Mountain Spotted Fever...
  35. Immunity directed against MSP 2 during anaplasmosis
    Jeffrey Abbott; Fiscal Year: 2004
    ..phagocytophila, the causative agent of human granulocytic ehrlichiosis (HGE)...
  36. Tropical Vector-borne Viral and Rickettsial Infections
    David Walker; Fiscal Year: 2007
    ..The studies will enhance knowledge of West Nile virus, Venezuelan equine encephalitis virus, other arboviruses, typhus, murine typhus, R. felis infections, and human ehrlichiosis in all parts of Mexico.
  37. Inhibition of NADPH oxidase by Anaplasma phagocytophila
    JASON CARLYON; Fiscal Year: 2007
    Human granulocytic ehrlichiosis (HGE) is an emerging infection of the blood that results in leukopenia and thrombocytopenia...
  38. HUMAN EHRLICHIOSIS SURVEILLANCE AND EPIDEMIOLOGY
    William Davidson; Fiscal Year: 2003
    DESCRIPTION (Adapted from the Applicant's Abstract): Two tick-borne ehrlichioses, human monocytic ehrlichiosis (HME) caused by Ehrlichia chaffeensis and human granulocytic ehrlichiosis (HGE) caused by Ehrlichia equi or a closely related ..
  39. GRANULOCYTIC EHRLICHIAS IN TICKS AND TICK CELL CULTURE
    Ulrike Munderloh; Fiscal Year: 2002
    The human granulocytic ehrlichiosis (HGE) agent is a newly identified zoonotic pathogen capable of causing a potentially fatal illness...
  40. Molecular Basis For Functional Diversity Of PSGL-1
    KAREN SNAPP; Fiscal Year: 2005
    ..PSGL- 1 also serves as the entry receptor for the pathogen responsible for Human Granulocytic Ehrlichiosis (HGE)...
  41. HUMAN GRANULOCYTIC EHRLICHIOSIS: NORTH CENTRAL U.S.
    Russell Johnson; Fiscal Year: 2005
    DESCRIPTION: Human granulocytic ehrlichiosis (HGE) is an emerging tick-borne acute febrile illness...
  42. Anaplasma marginale genes determining tick transmission
    MICHAEL DARK; Fiscal Year: 2007
    ..The genera Anaplasma and Ehriichia, including the organisms responsible for human anaplasmosis and human ehrlichiosis, require an ixodid tick vector for transmission from a mammalian reservoir to a susceptible host...
  43. MOLECULAR BASIS OF PERSISTENT EHRLICHIA INFECTION
    XUE JIE YU; Fiscal Year: 2004
    ..this proposal is Ehrlichia chaffeensis which causes a newly emerging infectious disease, human monocytotropic ehrlichiosis. Persistent infection by E. chaffeensis has been documented in human and animals...
  44. PHEROMONE/ACARICIDE MATRIX CONTROLS LYME DISEASE VECTOR
    John McLaughlin; Fiscal Year: 2003
    ..The target species, blacklegged tick transmits Lyme disease, two kinds of ehrlichiosis, and human babesiosis in the U.S...
  45. Ehrlichia Glycoprotein Modulation of Macrophage Gene Expression
    Jere McBride; Fiscal Year: 2009
    ..Ehrlichia chaffeensis, an obligate intracellular bacterium, is the agent of human monocytotropic ehrlichiosis (HME), a life-threatening emerging tick-borne zoonosis. During E...
  46. Granulocytic Ehrlichiosis: Cell-Pathogen Interactions
    Dori Borjesson; Fiscal Year: 2005
    Human granulocytic ehrlichiosis (HGE) is an emerging, potentially fatal, tick-borne zoonotic disease caused by an obligate intracellular bacterium...
  47. PROTECTIVE EPITOPES IN TICK IMMUNITY
    Fred Kantor; Fiscal Year: 2000
    ..of the antigens involved in tick immunity and study its effects upon the transmission of Lyme borreliosis and Ehrlichiosis. Specifically a model of tick protective immunity has been established in guinea pigs...
  48. EPIDEMIOLOGY & HISTORY--HUMAN GRANULOCYTIC EHRLICHIOSIS
    Janet Foley; Fiscal Year: 2000
    The proposed research improves our understanding of the zoonotic transmission of human granulocytic ehrlichiosis. The etiologic agent of this newly emerging, sometimes fatal zoonotic disease is antigenically and genetically almost ..
  49. EMERGING INFECTIONS PROGRAM
    Guthrie S Birkhead; Fiscal Year: 2011
    ..These includeMRSA, severepneumonia,pediatric influenza,unexplainedencephalitis,ehrlichiosis,norovirusesand CJD...
  50. Neutrophil gene expression induced by A. phagocytophila
    Erol Fikrig; Fiscal Year: 2004
    This application is a supplement to our recent proposal entitled "lmmunopathogenesis of granulocytic Ehrlichiosis" (R01 A1041440), in which we proposed to understand the pathogenesis of HGE using both in vitro and in vivo models...
  51. Regulation of gp91phox by Anaplasma phagocytophila
    Venetta Thomas; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): Human granulocytic ehrlichiosis is an emerging infectious disease caused by the tick-borne pathogen Anaplasma phagocytophila. A...
  52. PHEROMONE/ACARICIDE MATRIX CONTROLS LYME DISEASE VECTOR
    John McLaughlin; Fiscal Year: 2000
    ..The target species, blacklegged tick, transmits Lyme disease, two kinds of ehrlichiosis, and human babesiosis in the U.S...
  53. DETECTION AND RISK OF EHRLICHIAL DISEASES
    RICHARD FALCO; Fiscal Year: 2000
    DESCRIPTION (adapted from applicant's abstract): Human granulocytic ehrlichiosis (HGE) and human monocytic ehrlichiosis (HME) are emerging tick-borne disease in the U.S...
  54. Evaluation of Ehrlichial Antigens for Serodiagnosis
    Helene Paxton; Fiscal Year: 2001
    Human granulocytic ehrlichiosis (HGE) is an emerging tick-borne disease caused by an obligate intracellular bacterium in the genogroup Ehrlichia phagocytophila (EP). Human EP infections range from inapparent to fatal...
  55. Virulence and Immunity of Granulocytic Ehrlichiae
    JOHN DUMLER; Fiscal Year: 2007
    ..This information will provide a framework for rational design of therapies aimed at modulating immune injury and could foster design of preventative measures aimed at immunization. ..
  56. Virulence and Immunity of Granulocytic Ehrlichiae
    JOHN DUMLER; Fiscal Year: 2005
    Human granulocytic ehrlichiosis (HGE) is an emerging tick-borne infection caused by Anaplasma (Ehrlichia) phagocytophila, an obligate intracellular bacteria that infects neutrophils...
  57. ROLES OF EHRLICHIAL OUTER MEMBRANE PROTEIN IN PARASITISM
    Yasuko Rikihisa; Fiscal Year: 2001
    ..applicant's abstract): Ehrlichia species are emerging zoonotic pathogens that cause acute systemic diseases (ehrlichiosis) in humans. The human granulocytic ehrlichiosis (HGE) agent infects granulocytes. E. chaffeenis and E...
  58. GENE EXPRESSION BY HUMAN GRANULOCYTIC EHRLICHIOSIS AG
    Yasuko Rikihisa; Fiscal Year: 2004
    DESCRIPTION (Adapted from Applicant's Abstract): Human granulocytic ehrlichiosis (HGE) is a new tick-borne zoonosis that is increasingly recognized as a threat to public health in the United States...
  59. Comparison of Human Ehrlichiosis Agent Genomes
    Yasuko Rikihisa; Fiscal Year: 2010
    ..monocytes and macrophages, and causes a potentially fatal emerging infectious disease called Human monocytic ehrlichiosis (HME). The complete E. chaffeensis Arkansas genome sequence was published in 2006...
  60. Ehrilchiacidal Mechanisms In Leukocytes
    Yasuko Rikihisa; Fiscal Year: 2009
    Ehrlichia chaffeensis and Anaplasma phagocytophilum cause emerging infectious diseases, human monocytic ehrlichiosis (HME) and human granulocytic ehrlichiosis (HGE), respectively...
  61. Regulation of Recall Responses During Ehrlichiosis
    Gary M Winslow; Fiscal Year: 2010
    Human monocytic ehrlichiosis (HME) is a relatively new tick-borne disease caused by obligate intracellular bacteria of the genus ehrlichia...
  62. Antibody mediated intracellular bacterial elimination
    Gary Winslow; Fiscal Year: 2006
    ..system uses the obligate intracellular bacterium Ehrlichia chaffeensis, the etiologic agent of human monocytic ehrlichiosis (HME). Preliminary studies have confirmed the feasibility of the mouse model to study immunity to E...
  63. Cellular Immunity Against Ehrlichia chaffeensis
    ROMAN GANTA; Fiscal Year: 2002
    Human ehrlichiosis is caused by three agents including Ehrlichia chaffeensis, the human granulocytic ehrlichiosis agent and by E. ewengii...
  64. American Society for Rickettsiology Conference 2006
    ROMAN GANTA; Fiscal Year: 2006
    ..abstract_text> ..
  65. Infection Dynamics of Ehrlichia chaffeensis
    Andrea Varela Stokes; Fiscal Year: 2006
    ..is to elucidate the infection dynamics of Ehrlichia chaffeensis, the causative agent of human monocytic ehrlichiosis and the most important emerging tick-borne disease in the southeastern United States, in the natural wild ..