ehrlichiosis

Summary

Summary: A tick-borne disease characterized by FEVER; HEADACHE; myalgias; ANOREXIA; and occasionally RASH. It is caused by several bacterial species and can produce disease in DOGS; CATTLE; SHEEP; GOATS; HORSES; and humans. The primary species causing human disease are EHRLICHIA CHAFFEENSIS; ANAPLASMA PHAGOCYTOPHILUM; and Ehrlichia ewingii.

Top Publications

  1. pmc Human ehrlichiosis and anaplasmosis
    Nahed Ismail
    Department of Pathology, Meharry Medical College, Nashville, TN 37208, USA
    Clin Lab Med 30:261-92. 2010
  2. pmc Ehrlichia chaffeensis and Anaplasma phagocytophilum lack genes for lipid A biosynthesis and incorporate cholesterol for their survival
    Mingqun Lin
    Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA
    Infect Immun 71:5324-31. 2003
  3. pmc Invasion and intracellular development of the human granulocytic ehrlichiosis agent in tick cell culture
    U G Munderloh
    Department of Entomology, University of Minnesota, St Paul, Minnesota 55108, USA
    J Clin Microbiol 37:2518-24. 1999
  4. pmc Detection and identification of Ehrlichia, Borrelia burgdorferi sensu lato, and Bartonella species in Dutch Ixodes ricinus ticks
    L M Schouls
    Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Clin Microbiol 37:2215-22. 1999
  5. doi The natural history of Anaplasma phagocytophilum
    Zerai Woldehiwet
    University of Liverpool, Department of Veterinary Pathology, Veterinary Teaching Hospital, Leahurst, Neston, South Wirral CH64 7TE, UK
    Vet Parasitol 167:108-22. 2010
  6. pmc Distinct host species correlate with Anaplasma phagocytophilum ankA gene clusters
    Wiebke Scharf
    Institute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    J Clin Microbiol 49:790-6. 2011
  7. ncbi Detection of Borrelia burgdorferi, Ehrlichia chaffeensis, and Anaplasma phagocytophilum in ticks (Acari: Ixodidae) from a coastal region of California
    Kevin Holden
    Department of Biological Sciences, San Jose State University, San Jose, CA 95192, USA
    J Med Entomol 40:534-9. 2003
  8. pmc Isolation of the equine granulocytic ehrlichiosis agent, Ehrlichia equi, in tick cell culture
    U G Munderloh
    Department of Entomology, University of Minnesota, St Paul 55108, USA
    J Clin Microbiol 34:664-70. 1996
  9. pmc Emergence of the ehrlichioses as human health problems
    D H Walker
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
    Emerg Infect Dis 2:18-29. 1996
  10. pmc Ehrlichia chaffeensis: a prototypical emerging pathogen
    Christopher D Paddock
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Microbiol Rev 16:37-64. 2003

Research Grants

  1. Tick Midgut Proteins Critical for Borrelia Transmission
    Sukanya Narasimhan; Fiscal Year: 2009
  2. Tick Midgut Proteins Critical for Borrelia Transmission
    Sukanya Narasimhan; Fiscal Year: 2010
  3. Coinfection of Tick-borne Diseases in Areas of Wisconsin
    DIANE CAPORALE; Fiscal Year: 2001
  4. Landscape Ecology and Mapping of Ehrlichial Pathogens
    MICHAEL WIMBERLY; Fiscal Year: 2006
  5. Landscape Ecology and Mapping of Ehrlichial Pathogens
    MICHAEL WIMBERLY; Fiscal Year: 2005
  6. Infection Dynamics of Ehrlichia chaffeensis
    Andrea Varela Stokes; Fiscal Year: 2005
  7. Infection Dynamics of Ehrlichia chaffeensis
    Andrea Varela Stokes; Fiscal Year: 2004
  8. Interactions Between Anaplasma Phagocytophilum and Ixodes Scapularis
    Erol Fikrig; Fiscal Year: 2010
  9. EHRLICHIACIDAL MECHANISM BY LEUKOCYTES
    Yasuko Rikihisa; Fiscal Year: 1999
  10. Tropical Vector-borne Viral and Rickettsial Infections
    David Walker; Fiscal Year: 2006

Detail Information

Publications250 found, 100 shown here

  1. pmc Human ehrlichiosis and anaplasmosis
    Nahed Ismail
    Department of Pathology, Meharry Medical College, Nashville, TN 37208, USA
    Clin Lab Med 30:261-92. 2010
    Human ehrlichiosis and anaplasmosis are acute febrile tick-borne diseases caused by various members of the genera Ehrlichia and Anaplasma (Anaplasmataceae)...
  2. pmc Ehrlichia chaffeensis and Anaplasma phagocytophilum lack genes for lipid A biosynthesis and incorporate cholesterol for their survival
    Mingqun Lin
    Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA
    Infect Immun 71:5324-31. 2003
    ..Taken together, these results suggest that human ehrlichiosis agents became cholesterol dependent due to the loss of these genes...
  3. pmc Invasion and intracellular development of the human granulocytic ehrlichiosis agent in tick cell culture
    U G Munderloh
    Department of Entomology, University of Minnesota, St Paul, Minnesota 55108, USA
    J Clin Microbiol 37:2518-24. 1999
    ..ehrlichias are tick-borne bacterial pathogens that cause an acute, life-threatening illness, human granulocytic ehrlichiosis (HGE)...
  4. pmc Detection and identification of Ehrlichia, Borrelia burgdorferi sensu lato, and Bartonella species in Dutch Ixodes ricinus ticks
    L M Schouls
    Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Clin Microbiol 37:2215-22. 1999
    ..phagocytophila and the human granulocytic ehrlichiosis agent. The majority of the other positive ticks were infected with a newly identified Ehrlichia-like species...
  5. doi The natural history of Anaplasma phagocytophilum
    Zerai Woldehiwet
    University of Liverpool, Department of Veterinary Pathology, Veterinary Teaching Hospital, Leahurst, Neston, South Wirral CH64 7TE, UK
    Vet Parasitol 167:108-22. 2010
    ..species of granulocytic bacteria, Ehrlichia phagocytophila, Ehrlichia equi and the agent of human granulocytic ehrlichiosis, after the recent reorganization of the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales...
  6. pmc Distinct host species correlate with Anaplasma phagocytophilum ankA gene clusters
    Wiebke Scharf
    Institute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    J Clin Microbiol 49:790-6. 2011
    ..Whereas the phylogenetic analysis using 16S rRNA gene sequences was not meaningful, we showed that distinct host species correlate with A. phagocytophilum ankA gene clusters...
  7. ncbi Detection of Borrelia burgdorferi, Ehrlichia chaffeensis, and Anaplasma phagocytophilum in ticks (Acari: Ixodidae) from a coastal region of California
    Kevin Holden
    Department of Biological Sciences, San Jose State University, San Jose, CA 95192, USA
    J Med Entomol 40:534-9. 2003
    ..prevalence and distribution of the agents of Lyme disease, human granulocytic (HGE), and human monocytic (HME) ehrlichiosis in 1,187 adult ixodid ticks collected from eight public-use recreation areas over a 2-yr period...
  8. pmc Isolation of the equine granulocytic ehrlichiosis agent, Ehrlichia equi, in tick cell culture
    U G Munderloh
    Department of Entomology, University of Minnesota, St Paul 55108, USA
    J Clin Microbiol 34:664-70. 1996
    The equine granulocytic ehrlichiosis agent, Ehrlichia equi, is closely related or identical to the human granulocytic ehrlichiosis (HGE) agent. Both are suspected of being transmitted by ticks. We have successfully isolated E...
  9. pmc Emergence of the ehrlichioses as human health problems
    D H Walker
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
    Emerg Infect Dis 2:18-29. 1996
    ..Likewise, approximately 170 cases of human granulocytic ehrlichiosis have been diagnosed, most since 1994, predominantly in the upper midwestern and northeastern states, but also ..
  10. pmc Ehrlichia chaffeensis: a prototypical emerging pathogen
    Christopher D Paddock
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Microbiol Rev 16:37-64. 2003
    ..features, and laboratory diagnosis of the zoonotic disease it causes (commonly referred to as human monocytic ehrlichiosis [HME]) has expanded considerably in the period since its discovery...
  11. pmc Comparison of simultaneous splenic sample PCR with blood sample PCR for diagnosis and treatment of experimental Ehrlichia canis infection
    Shimon Harrus
    School of Veterinary Medicine, Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Antimicrob Agents Chemother 48:4488-90. 2004
    This report presents evidence that dogs recover from acute canine monocytic ehrlichiosis (CME) after 16 days of doxycycline treatment (10 mg/kg of body weight every 24 h)...
  12. pmc Postgenomic analyses reveal development of infectious Anaplasma phagocytophilum during transmission from ticks to mice
    Juliana E Mastronunzio
    Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA
    J Bacteriol 194:2238-47. 2012
    ..phagocytophilum during transmission from ticks to mammals and demonstrates that the abundantly expressed, DC-associated APH_1235 protein is important during in vivo infection by A. phagocytophilum...
  13. doi Molecular detection of Anaplasma phagocytophilum in the European hedgehog (Erinaceus europaeus) and its ticks
    Jasmin Skuballa
    Department of Ecology and Parasitology, Zoological Institute, Karlsruhe Institute of Technology, Karlsruhe, Germany
    Vector Borne Zoonotic Dis 10:1055-7. 2010
    ..Thus, this species may play a role in human contact with zoonotic diseases. Here we report the presence of the pathogen Anaplasma phagocytophilum in hedgehogs and their ticks in Germany...
  14. pmc Persistent Ehrlichia chaffeensis infection occurs in the absence of functional major histocompatibility complex class II genes
    Roman Reddy Ganta
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506, USA
    Infect Immun 70:380-8. 2002
    Human monocytic ehrlichiosis is an emerging tick-borne disease caused by the rickettsia Ehrlichia chaffeensis. We investigated the impact of two genes that control macrophage and T-cell function on murine resistance to E. chaffeensis...
  15. ncbi Investigation of Anaplasma phagocytophila infections in Ixodes ricinus and Dermacentor reticulatus ticks in Austria
    Wolfdieter Sixl
    Institute of Hygiene, University of Graz, Graz, Austria
    Ann N Y Acad Sci 990:94-7. 2003
  16. pmc Delineating Anaplasma phagocytophilum ecotypes in coexisting, discrete enzootic cycles
    Kevin J Bown
    University of Liverpool, Liverpool, UK
    Emerg Infect Dis 15:1948-54. 2009
    ..phagocytophilum are restricted to coexisting but separate enzootic cycles and suggest that this restriction may result from specific vector compatibility...
  17. pmc Sequence analysis of the ank gene of granulocytic ehrlichiae
    R F Massung
    Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 38:2917-22. 2000
    The ank gene of the agent of human granulocytic ehrlichiosis (HGE) codes for a protein with a predicted molecular size of 131.2 kDa that is recognized by serum from both dogs and humans infected with granulocytic ehrlichiae...
  18. doi Prevalence of Anaplasma phagocytophilum and coinfection with Borrelia burgdorferi sensu lato in the hard tick Ixodes ricinus in the city of Hanover (Germany)
    Sabine Schicht
    Institute for Parasitology, University of Veterinary Medicine Hannover, Hannover, Germany
    Vector Borne Zoonotic Dis 11:1595-7. 2011
    ..Coinfections with B. burgdorferi sl were found in 0.9% of all tick stages. The detected genospecies were B. afzelii, B. garinii, B. burgdorferi sensu stricto (ss), and B. garinii, which was the most frequent species in coinfected ticks...
  19. pmc Exit mechanisms of the intracellular bacterium Ehrlichia
    Sunil Thomas
    Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 5:e15775. 2010
    ..Ehrlichia chaffeensis that resides in mononuclear phagocytes is the causative agent of human monocytotropic ehrlichiosis. Ehrlichia muris and Ixodes ovatus Ehrlichia (IOE) are agents of mouse models of ehrlichiosis...
  20. doi Nosocomial transmission of human granulocytic anaplasmosis in China
    Lijuan Zhang
    National Institute of Communicable Disease Control and Prevention, China, CDC, Beijing, China, PO Box 5, Changping, Beijing, China 102206
    JAMA 300:2263-70. 2008
    ..A cluster of cases among health care workers and family members following exposure to a patient with fulminant disease consistent with HGA prompted investigation...
  21. ncbi Emerging and re-emerging tick-transmitted rickettsial and ehrlichial infections
    David H Walker
    Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0609, USA
    Med Clin North Am 92:1345-61, x. 2008
    ..Globally, many of these bacteria have been named but the genetic differences among them are often small, and many of their clinical manifestations may not be distinguishable diagnostically...
  22. doi Anaplasma phagocytophilum and Ehrlichia chaffeensis: subversive manipulators of host cells
    Yasuko Rikihisa
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, Ohio 43210, USA
    Nat Rev Microbiol 8:328-39. 2010
    ..Here, I review the specialized properties and other adaptations of these intracellular bacteria...
  23. pmc Relative importance of Ixodes ricinus and Ixodes trianguliceps as vectors for Anaplasma phagocytophilum and Babesia microti in field vole (Microtus agrestis) populations
    K J Bown
    Department of Veterinary Pathology, University of Liverpool, Neston, Cheshire, United Kingdom
    Appl Environ Microbiol 74:7118-25. 2008
    ..This study provides compelling evidence for the importance of I. trianguliceps in maintaining these enzootic tick-borne infections, while highlighting the potential for such infections to escape into alternative hosts via I. ricinus...
  24. ncbi Effect of tick removal on transmission of Borrelia burgdorferi and Ehrlichia phagocytophila by Ixodes scapularis nymphs
    F des Vignes
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06520-0834, USA
    J Infect Dis 183:773-8. 2001
    ..spirochete Borrelia burgdorferi and field strains of Ehrlichia phagocytophila, an agent of human granulocytic ehrlichiosis. Infected nymphal Ixodes scapularis were allowed to feed individually on mice, and equal numbers were removed ..
  25. pmc Comparative genomics of emerging human ehrlichiosis agents
    Julie C Dunning Hotopp
    The Institute for Genomic Research, Rockville, Maryland, USA
    PLoS Genet 2:e21. 2006
    ..and Neorickettsia (formerly Ehrlichia) sennetsu are intracellular vector-borne pathogens that cause human ehrlichiosis, an emerging infectious disease...
  26. ncbi Ixodes ricinus as a vector of Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum and Babesia microti in urban and suburban forests
    Joanna Stanczak
    Medical University of Gdansk, Interfaculty Institute of Maritime and Tropical Medicine, 9B Powstania Styczniowego str, 81 519 Gdynia, Poland
    Ann Agric Environ Med 11:109-14. 2004
    ..3 %). Among adult ticks (n = 303), 8.3 % were dually infected with A. phagocytophilum and B. burgdorferi s.l., 2.0 % with the agent of human anaplasmosis and B. microti and 0.3 % with borreliae and B. microti...
  27. doi Prevalence of Anaplasma phagocytophilum and its coinfection with Borrelia afzelii in Ixodes ricinus and Ixodes persulcatus ticks inhabiting Tver Province (Russia) - a sympatric region for both tick species
    Toshiyuki Masuzawa
    Laboratory of Microbiology and Immunology, Faculty of Pharmacy, Chiba Institute of Science CIS, Choshi 288 0025, Japan
    J Med Microbiol 57:986-91. 2008
    ..phagocytophilum strains to specific vector ticks or reservoir hosts in different countries and areas. These findings suggest that there is a public health threat from HGA and LB in Tver Province surrounding Moscow...
  28. pmc Agents of human anaplasmosis and Lyme disease at Camp Ripley, Minnesota
    RUSSELL C JOHNSON
    University of Minnesota, Department of Microbiology, Minneapolis, Minnesota 55455, USA
    Vector Borne Zoonotic Dis 11:1529-34. 2011
    ..Antibodies to Bb were detected in >80% of the deer, but Bb DNA was only detected in 1.5% of blood specimens...
  29. pmc The interaction between IL-18 and IL-18 receptor limits the magnitude of protective immunity and enhances pathogenic responses following infection with intracellular bacteria
    Purnima Ghose
    Department of Pathology, Meharry Medical College, Nashville, TN 37028, USA
    J Immunol 187:1333-46. 2011
    ..Together, these results suggested that the presence or absence of IL-18R signals governs the pathogenic versus protective immunity in a model of Ehrlichia-induced immunopathology...
  30. ncbi Canine ehrlichiosis
    Bogumila Skotarczak
    Department of Genetics, Faculty of Biology, Szczecin University, Piastow 40B, 71 065 Szczecin, Poland
    Ann Agric Environ Med 10:137-41. 2003
    ..The agent causing canine granulocytic ehrlichiosis (CGE) in Europe has been determined by nucleotide sequencing of the 16S rRNA gene to be similar to both ..
  31. ncbi Human Granulocytic Ehrlichiosis in Belgium: an underestimated cause of disease
    P Heyman
    Research Laboratory for Vector Borne Diseases, Queen Astrid Military Hospital, Bruynstraat 1, Brussels B 1120, Belgium
    J Infect 47:129-32. 2003
    Human Granulocytic Ehrlichiosis (HGE) is a recently discovered zoonosis and, in Europe, not always included in laboratory testing when a patient presents with a history of tick bite...
  32. pmc Correlation between tick density and pathogen endemicity, New Hampshire
    Seth T Walk
    University of Massachusetts, Amherst, Massachusetts, USA
    Emerg Infect Dis 15:585-7. 2009
    ..Pathogens were more prevalent in areas of high tick density, suggesting a correlation between tick establishment and pathogen endemicity. Infection rates in ticks correlated with disease frequency in humans...
  33. pmc Regulatory roles of CD1d-restricted NKT cells in the induction of toxic shock-like syndrome in an animal model of fatal ehrlichiosis
    H L Stevenson
    Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555 0609, USA
    Infect Immun 76:1434-44. 2008
    ..Using a murine model of fatal ehrlichiosis, we investigated the role of CD1d-restricted NKT cells in induction of toxic shock-like syndrome caused by gram-..
  34. pmc Anaplasma phagocytophilum increases cathepsin L activity, thereby globally influencing neutrophil function
    Venetta Thomas
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8031, USA
    Infect Immun 76:4905-12. 2008
    ..As therapeutic options for A. phagocytophilum and related organisms are limited, these results also identify a cellular pathway that may be targeted for the treatment of A. phagocytophilum infection...
  35. ncbi Significance of serological testing for ehrlichial diseases in dogs with special emphasis on the diagnosis of canine monocytic ehrlichiosis caused by Ehrlichia canis
    T Waner
    Israel Institute for Biological Research, P O Box 19, Ness Ziona 70400, Israel
    Vet Parasitol 95:1-15. 2001
    Dogs are susceptible to a number of ehrlichial diseases. Among them, canine monocytic ehrlichiosis is an important and potentially fatal disease of dogs caused by the rickettsia Ehrlichia canis...
  36. pmc Anaplasma phagocytophilum infection in small mammal hosts of Ixodes ticks, western United States
    Janet E Foley
    University of California, Davis, California, USA
    Emerg Infect Dis 14:1147-50. 2008
    ..High seroprevalence was observed in northern sites. Ten tick species were identified. Heavily infested rodent species included meadow voles, woodrats, deer mice, and redwood chipmunks...
  37. doi Clinical, serological, and molecular evidence of ehrlichiosis and anaplasmosis in dogs in Tunisia
    Y M'Ghirbi
    Service d Entomologie Médicale, Institut Pasteur de Tunis, 1002 Tunis, Tunisia
    Parasitol Res 104:767-74. 2009
    ..to Ehrlichia canis and Anaplasma phagocytophilum antigens, surrogate markers of the agents of canine monocytic ehrlichiosis (CME) and canine granulocytic ehrlichiosis, respectively. Among 286 collected sera, 54.2% and 25...
  38. pmc Multiplex detection of Ehrlichia and Anaplasma species pathogens in peripheral blood by real-time reverse transcriptase-polymerase chain reaction
    Kamesh R Sirigireddy
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, 1800 Denison Ave, Manhattan, Kansas 66506, USA
    J Mol Diagn 7:308-16. 2005
    ..The test was assessed by examining blood samples from dogs suspected to be positive for ehrlichiosis. The dog was chosen as the model system because it is susceptible to acquire infections with up to five ..
  39. ncbi A survey on Anaplasma phagocytophila in wild small mammals and roe deer (Capreolus capreolus) in Northern Spain
    Beatriz Oporto
    NEIKER, Departamento Sanidad Animal, Berreaga 1, 48160 Derio, Bizkaia, Spain
    Ann N Y Acad Sci 990:98-102. 2003
  40. pmc Diminished adhesion of Anaplasma phagocytophilum-infected neutrophils to endothelial cells is associated with reduced expression of leukocyte surface selectin
    Kyoung Seong Choi
    Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Infect Immun 71:4586-94. 2003
    ..These observations may help us to understand the modified biological responses, host inflammation, and immune response that occur with A. phagocytophilum infections...
  41. ncbi Hepatic pathology in human monocytic ehrlichiosis. Ehrlichia chaffeensis infection
    Ann E Sehdev
    Dept of Pathology, Johns Hopkins Medical Institutions, Meyer B1 193, 600 N Wolfe St, Baltimore, MD 21287, USA
    Am J Clin Pathol 119:859-65. 2003
    Ehrlichia chaffeensis causes human monocytic ehrlichiosis (HME) that usually includes fever, myalgias, and pancytopenia and, in 80% to 90% of patients, elevations in serum transaminase levels...
  42. pmc The biological basis of severe outcomes in Anaplasma phagocytophilum infection
    J Stephen Dumler
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    FEMS Immunol Med Microbiol 64:13-20. 2012
    ..Whether severity relates to microbial factors or genetically determined diversity in human immune and inflammatory response needs more investigation...
  43. ncbi Comparative vector competence of Dermacentor variabilis and Ixodes scapularis (Acari: Ixodidae) for the agent of human granulocytic ehrlichiosis
    F des Vignes
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06520 8034, USA
    J Med Entomol 36:182-5. 1999
    Vector competence of Ixodes scapularis Say and Dermacentor variabilis Say for the agent of human granulocytic ehrlichiosis (HGE) was compared...
  44. doi Anaplasma phagocytophilum in livestock and small rodents
    Lin Zhan
    State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 20 Dong Da Street, Fengtai District, Beijing 100071, People s Republic of China
    Vet Microbiol 144:405-8. 2010
    ..phagocytophilum in rodents might be able to infect livestock and intensified the threats of anaplasmosis to livestock in the area. Further studies on public health significance of the agent are worth investigation in future...
  45. pmc Relative importance of T-cell subsets in monocytotropic ehrlichiosis: a novel effector mechanism involved in Ehrlichia-induced immunopathology in murine ehrlichiosis
    Nahed Ismail
    Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, 301 University Blvd, Galveston, TX 77555 0609, USA
    Infect Immun 75:4608-20. 2007
    ..we investigated the role of CD4(+) and CD8(+) T cells in immunity to Ehrlichia and the pathogenesis of fatal ehrlichiosis caused by infection with low- and high-dose (10(3) and 10(5) bacterial genomes/mouse, respectively) ehrlichial ..
  46. ncbi The ascendancy of Amblyomma americanum as a vector of pathogens affecting humans in the United States
    James E Childs
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Annu Rev Entomol 48:307-37. 2003
    ....
  47. ncbi Molecular evidence for Anaplasma phagocytophilum and Borrelia burgdorferi sensu lato in Ixodes ricinus ticks from eastern Slovakia
    Marketa Derdakova
    Faculty of Medicine, P J Safarik University, Srobarova 2, 041 80 Kosice, Slovak Republic
    Ann Agric Environ Med 10:269-71. 2003
    ..These results indicate that both B. burgdorferi s.l. and A. phagocytophilum co-circulate in the enzootic sites of Eastern Slovakia and may cause co-infection in humans...
  48. ncbi Cultivation of an ovine strain of Ehrlichia phagocytophila in tick cell cultures
    Z Woldehiwet
    Department of Veterinary Pathology, University of Liverpool, PO Box 147, Liverpool, L69 3BX, UK
    J Comp Pathol 127:142-9. 2002
    ..phagocytophila. A susceptible sheep inoculated with a third passage of the tick cell-adapted E. phagocytophila reacted with fever and rickettsiaemia 5 days later, thus satisfying Koch's postulates...
  49. ncbi Infection rates of Amblyomma americanum and Dermacentor variabilis by Ehrlichia chaffeensis and Ehrlichia ewingii in southwest Missouri
    John G Steiert
    Department of Biology, Southwest Missouri State University, Springfield, MO 65804, USA
    Vector Borne Zoonotic Dis 2:53-60. 2002
    Both Ehrlichia chaffeensis and Ehrlichia ewingii are causative agents of human ehrlichiosis. Both pathogens are transmitted to humans through the bite of an infected lone star tick (Amblyomma americanum)...
  50. doi Anaplasma phagocytophilum seroprevalence in equids: a survey in Sicily (Italy)
    Elisabetta Giudice
    Dipartimento di Sanità Pubblica Veterinaria, Facolta di Medicina Veterinaria, Universita degli Studi di Messina, Polo Universitario dell Annunziata, 98168 Messina, Italy
    Parasitol Res 111:951-5. 2012
    ..However, further studies are necessary to elucidate the possible mechanisms that involve the Equidae as host of this pathogen...
  51. ncbi Prevalence of Borrelia burgdorferi s.l. and Anaplasma phagocytophilum in the wood tick Ixodes ricinus in the Province of Trento, Italy
    B Mantelli
    Centro di Ecologia Alpina, 38040, Viote del Monte Bondone, Trento, Italy
    Eur J Clin Microbiol Infect Dis 25:737-9. 2006
  52. doi Genetic variants of Anaplasma phagocytophilum in wild caprine and cervid ungulates from the Alps in Tyrol, Austria
    Cornelia Silaghi
    Faculty of Veterinary Medicine and Parasitology, Institute of Comparative Tropical Medicine and Parasitology, Ludwig Maximilians University, Leopoldstrasse 5, Munich, Germany
    Vector Borne Zoonotic Dis 11:355-62. 2011
    ..phagocytophilum. The pathogenicity of the variants and the reservoir competence of the species investigated in this study deserve further attention in future studies...
  53. pmc Hemocytic rickettsia-like organisms in ticks: serologic reactivity with antisera to Ehrlichiae and detection of DNA of agent of human granulocytic ehrlichiosis by PCR
    L A Magnarelli
    Department of Entomology, Connecticut Agricultural Experiment Station, New Haven 06504, USA
    J Clin Microbiol 33:2710-4. 1995
    ..canis and/or E. equi antisera, including sera from persons who had granulocytic ehrlichiosis. In separate PCR analyses, DNA of the agent of human granulocytic ehrlichiosis was detected in 59 (50...
  54. doi Diagnosis of canine monocytotropic ehrlichiosis (Ehrlichia canis): an overview
    Shimon Harrus
    Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel
    Vet J 187:292-6. 2011
    Canine monocytotropic ehrlichiosis (CME), caused by the rickettsia Ehrlichia canis, an important canine disease with a worldwide distribution...
  55. ncbi The relationship between the degree of thrombocytopenia and infection with Ehrlichia canis in an endemic area
    Camilo Bulla
    Clinical Pathology Laboratory, Departamento de Clínica Veterinária, Faculdade de Medicina Veterinaria e Zootecnia, Universidade Estadual Paulista, Botucatu, Brazil
    Vet Res 35:141-6. 2004
    Ehrlichia canis is the causative agent of canine monocytic ehrlichiosis. In order to evaluate platelet counts as a screening test for E...
  56. doi Infections with Anaplasma phagocytophilum in dogs in Germany
    B Kohn
    Small Animal Clinic, Faculty of Veterinary Medicine, Freie Universitat Berlin, Berlin, Germany
    Res Vet Sci 91:71-6. 2011
    ..The CBC was within reference range in 10 PCR-positive clinically healthy dogs suggesting a routine examination of blood donors for A. phagocytophilum in endemic areas to minimize the risk of transmission...
  57. pmc Efficacy of a doxycycline treatment regimen initiated during three different phases of experimental ehrlichiosis
    Jennifer C McClure
    Department of Veterinary Pathobiology, University of Missouri, 210 Connaway Hall, Columbia, Missouri 65211, USA
    Antimicrob Agents Chemother 54:5012-20. 2010
    Doxycycline is the treatment of choice for canine monocytic ehrlichiosis (CME), a well-characterized disease and valuable model for tick-borne zoonoses...
  58. ncbi Ehrlichiosis and related infections
    Leah A Cohn
    College of Veterinary Medicine, University of Missouri Columbia, 379 East Campus, Clydesdale Hall, Columbia, MO 65211, USA
    Vet Clin North Am Small Anim Pract 33:863-84. 2003
    b>Ehrlichiosis is a term that has been used to describe infection with any of a number of related intracellular, vector-borne pathogens...
  59. ncbi Evaluation of cytology in the diagnosis of acute canine monocytic ehrlichiosis (Ehrlichia canis): a comparison between five methods
    M E Mylonakis
    Clinic of Companion Animal Medicine, Faculty of Veterinary Medicine, School of Veterinary Medicine, Aristotles University of Thessaloniki, Thessaloniki, Greece
    Vet Microbiol 91:197-204. 2003
    ..that has been based on the detection of Ehrlichia canis morulae, in the acute phase of canine monocytic ehrlichiosis (CME). Their cellular localization, total numbers and microscopic differentials were also investigated...
  60. pmc Wild boars as hosts of human-pathogenic Anaplasma phagocytophilum variants
    Jerzy Michalik
    Department of Animal Morphology, Faculty of Biology, Adam Mickiewicz University, Poznan, Poland
    Emerg Infect Dis 18:998-1001. 2012
    ..phagocytophilum variants, including a predominance of strains known to cause human disease. Boars are thus hosts for A. phagocytophilum, notably, strains associated with human granulocytic anaplasmosis...
  61. ncbi Antibodies highly effective in SCID mice during infection by the intracellular bacterium Ehrlichia chaffeensis are of picomolar affinity and exhibit preferential epitope and isotype utilization
    Julia Shu Yi Li
    Department of Biomedical Sciences, School of Public Health, State University of New York, Albany, NY 12201, USA
    J Immunol 169:1419-25. 2002
    ..Thus, although epitope recognition and isotype use may contribute to efficacy, high affinity may be a critical characteristic of Abs that can act effectively during this intracellular bacterial infection...
  62. ncbi A case of equine granulocytic ehrlichiosis provides molecular evidence for the presence of pathogenic anaplasma phagocytophilum (HGE agent) in Germany
    F D Von Loewenich
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Wasserturmstrasse 3 5, 91054, Erlangen, Germany
    Eur J Clin Microbiol Infect Dis 22:303-5. 2003
    Based on seroprevalence studies and tick infection rates, tick-borne human granulocytic ehrlichiosis (HGE) is thought to occur in Germany, but to date no clinical case has been detected...
  63. pmc Emergence of a new pathogenic Ehrlichia species, Wisconsin and Minnesota, 2009
    Bobbi S Pritt
    Mayo Clinic, Division of Clinical Microbiology, Hilton 470 B, 200 1st St SW, Rochester, MN 55905, USA
    N Engl J Med 365:422-9. 2011
    b>Ehrlichiosis is a clinically important, emerging zoonosis. Only Ehrlichia chaffeensis and E. ewingii have been thought to cause ehrlichiosis in humans in the United States...
  64. pmc Diminished hematopoietic activity associated with alterations in innate and adaptive immunity in a mouse model of human monocytic ehrlichiosis
    Katherine C MacNamara
    New York State Department of Health, Wadsworth Center, Albany, New York 12201 2002, USA
    Infect Immun 77:4061-9. 2009
    Human monocytic ehrlichiosis (HME) is a tick-borne disease caused by Ehrlichia chaffeensis...
  65. ncbi Outer membrane protein-specific monoclonal antibodies protect SCID mice from fatal infection by the obligate intracellular bacterial pathogen Ehrlichia chaffeensis
    J S Li
    Department of Biomedical Sciences, School of Public Health, State University of New York, Albany, NY 12201, USA
    J Immunol 166:1855-62. 2001
    ....
  66. pmc Transcript heterogeneity of the p44 multigene family in a human granulocytic ehrlichiosis agent transmitted by ticks
    Ning Zhi
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210 1093, USA
    Infect Immun 70:1175-84. 2002
    Human granulocytic ehrlichiosis (HGE) is an emerging tick-borne zoonosis caused by a strain of Anaplasma phagocytophila called the HGE agent, an obligatory intracellular bacterium...
  67. pmc Molecular characterization of antibody epitopes of Ehrlichia chaffeensis ankyrin protein 200 and tandem repeat protein 47 and evaluation of synthetic immunodeterminants for serodiagnosis of human monocytotropic ehrlichiosis
    Tian Luo
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Clin Vaccine Immunol 17:87-97. 2010
    ..respectively) in terminal acidic domains, which reacted with antibodies in sera from human monocytotropic ehrlichiosis (HME) patients and an E. chaffeensis-infected dog...
  68. pmc An intradermal environment promotes a protective type-1 response against lethal systemic monocytotropic ehrlichial infection
    Heather L Stevenson
    Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555 0609, USA
    Infect Immun 74:4856-64. 2006
    Immune responses against monocytotropic ehrlichiosis during infection with a strain of Ehrlichia from Ixodes ovatus (IOE) were evaluated using a model that closely reproduces the pathology and immunity associated with tick-transmitted ..
  69. pmc Variant -and individual dependent nature of persistent Anaplasma phagocytophilum infection
    Erik G Granquist
    Department of Production Animal Clinical Sciences, Section of Small Ruminant Research, Norwegian School of Veterinary Science, Sandnes, N 4325, Norway
    Acta Vet Scand 52:25. 2010
    ..Little is known about how different strains of A. phagocytophilum propagate in their natural hosts during persistent infection...
  70. pmc The omp-1 major outer membrane multigene family of Ehrlichia chaffeensis is differentially expressed in canine and tick hosts
    Ahmet Unver
    Department of Veterinary Biosciences, The Ohio State University, Columbus 43210 1093, USA
    Infect Immun 70:4701-4. 2002
    ..Only one paralog was transcribed by E. chaffeensis in three developmental stages of Amblyomma americanum ticks before or after E. chaffeensis transmission to naïve dogs...
  71. pmc Anaplasma phagocytophilum in white-tailed deer
    Robert F Massung
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 11:1604-6. 2005
    ..These results will affect surveillance studies of vector and reservoir populations...
  72. ncbi Highly variable year-to-year prevalence of Anaplasma phagocytophilum in Ixodes ricinus ticks in northeastern Poland: a 4-year follow-up
    Anna Grzeszczuk
    Medical University of Białystok, Department of Infectious Diseases, 14 Zurawia Str, 15 540 Białystok, Poland
    Ann N Y Acad Sci 1078:309-11. 2006
    ..8% verses males 8.2% and nymphs 0.9%). We noted a very big year-to-year variation of infection prevalence in each collection cite every year reflecting changeable granulocytic anaplasmosis risk for humans and animals...
  73. pmc Survival, replication, and antibody susceptibility of Ehrlichia chaffeensis outside of host cells
    Julia Shu Yi Li
    Wadsworth Center, New York State Department of Health, and Department of Biomedical Sciences, School of Public Health, University at Albany, Albany, New York 12201, USA
    Infect Immun 71:4229-37. 2003
    ....
  74. pmc Anaplasma phagocytophilum-infected ticks, Japan
    Norio Ohashi
    Laboratory of Experimental Microbiology, Institute for Environmental Sciences, University of Shizuoka, 52 1 Yada, Suruga, Shizuoka 422 8526, Japan
    Emerg Infect Dis 11:1780-3. 2005
    ..Unique p44/msp2 paralogs (and/or 16S rRNA genes) were detected in tick tissues, salivary glands, and spleens of experimentally infected mice. These findings indicate the public health threat of anaplasmosis in Japan...
  75. pmc Expression of multiple outer membrane protein sequence variants from a single genomic locus of Anaplasma phagocytophilum
    A F Barbet
    Department of Pathobiology, College of Veterinary Medicine, University of Florida, PO Box 110880, Gainesville, FL 32611, USA
    Infect Immun 71:1706-18. 2003
    ..marginale, A. phagocytophilum uses combinatorial mechanisms to generate a large array of outer membrane protein variants. Such gene polymorphism has profound implications for the design of vaccines, diagnostic tests, and therapy...
  76. pmc Expression of members of the 28-kilodalton major outer membrane protein family of Ehrlichia chaffeensis during persistent infection
    Jian Zhi Zhang
    Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
    Infect Immun 72:4336-43. 2004
    ..The antibody responses to another outer membrane protein of E. chaffeensis (GP120) showed similar temporal and quantitative changes. These data suggest that the P28 OMPs are expressed concurrently during persistent Ehrlichia infection...
  77. ncbi Disease-specific diagnosis of coinfecting tickborne zoonoses: babesiosis, human granulocytic ehrlichiosis, and Lyme disease
    Peter J Krause
    Department of Pediatrics, Medicine, Clinical Microbiology, Genetics, and Developmental Biology, and The Center for Microbial Pathogenesis, University of Connecticut School of Medicine, Farmington, CT, USA
    Clin Infect Dis 34:1184-91. 2002
    ..chain reaction (PCR) testing after developing symptoms of Lyme disease, human babesiosis, or human granulocytic ehrlichiosis (HGE)...
  78. ncbi Ecological havoc, the rise of white-tailed deer, and the emergence of Amblyomma americanum-associated zoonoses in the United States
    C D Paddock
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Curr Top Microbiol Immunol 315:289-324. 2007
    ..These three conditions-human monocytic (or monocytotropic) ehrlichiosis (HME), Ehrlichia ewingii ehrlichiosis, and southern tick-associated rash illness (STARI)-undoubtedly existed in ..
  79. pmc Survival strategy of obligately intracellular Ehrlichia chaffeensis: novel modulation of immune response and host cell cycles
    Jian Zhi Zhang
    Departments of Pathology and Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    Infect Immun 72:498-507. 2004
    ....
  80. pmc Histologic, serologic, and molecular analysis of persistent ehrlichiosis in a murine model
    Juan P Olano
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Am J Pathol 165:997-1006. 2004
    Human monocytotropic ehrlichiosis caused by Ehrlichia chaffeensis was reported in 1987...
  81. ncbi Infections of wild animals with Anaplasma phagocytophila in Austria and the Czech Republic
    Miroslav Petrovec
    Institute of Microbiology and Immunology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia
    Ann N Y Acad Sci 990:103-6. 2003
  82. ncbi Human granulocytic ehrlichiosis in Italy: first report on two confirmed cases
    Maurizio Ruscio
    Hospital of San Daniele del Friuli, San Daniele, Italy
    Ann N Y Acad Sci 990:350-2. 2003
    We report here the two first cases of human ehrlichiosis described in Italy...
  83. ncbi Infections with Ehrlichia chaffeensis and Ehrlichia ewingii in persons coinfected with human immunodeficiency virus
    C D Paddock
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 33:1586-94. 2001
    ..virus (HIV) and Ehrlichia chaffeensis or Ehrlichia ewingii are reviewed and summarized, including 13 cases of ehrlichiosis caused by E. chaffeensis, 4 caused by E. ewingii, and 4 caused by either E. chaffeensis or E. ewingii...
  84. ncbi Tick- and flea-borne rickettsial emerging zoonoses
    Philippe Parola
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille Cedex 5, France
    Vet Res 36:469-92. 2005
    ..implicated in human diseases in recent years, including Ehrlichia chaffeensis, the agent of human monocytic ehrlichiosis, Anaplasma phagocytophilum, the agent of human anaplasmosis (formerly known as "human granulocytic ..
  85. pmc Progress and obstacles in vaccine development for the ehrlichioses
    Jere W McBride
    Department of Pathology, Center for Emerging Infectious Diseases and Biodefense, Sealy Center for Vaccine Development, and the Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Expert Rev Vaccines 9:1071-82. 2010
    ....
  86. ncbi Clinical and epidemiological features of early Lyme disease and human granulocytic ehrlichiosis in Wisconsin
    E A Belongia
    Epidemiology Research Center, Marshfield Medical Research Foundation, Marshfield, WI 54449, USA
    Clin Infect Dis 29:1472-7. 1999
    To compare clinical features and assess risk factors for human granulocytic ehrlichiosis (HGE) and early Lyme disease, we enrolled patients in a case-control study during the 1996 and 1997 tick seasons...
  87. pmc T-Cell-independent humoral immunity is sufficient for protection against fatal intracellular ehrlichia infection
    Constantine Bitsaktsis
    Wadsworth Center, New York State Department of Health, PO Box 22002, Albany, New York 12201 2002, USA
    Infect Immun 75:4933-41. 2007
    ..muris can induce class switch recombination in the absence of classical T-cell-mediated help. These studies highlight a major protective role for classical T-cell-independent humoral immunity during an intracellular bacterial infection...
  88. ncbi Clinical relevance of annual screening using a commercial enzyme-linked immunosorbent assay (SNAP 3Dx) for canine ehrlichiosis
    Barbara C Hegarty
    Intracellular Pathogens Research Laboratory, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA
    J Am Anim Hosp Assoc 45:118-24. 2009
    ..In this study, thrombocytopenia was frequently detected in healthy Ehrlichia SNAP 3Dx-positive dogs, whereas active infection was infrequently confirmed by PCR. Therefore, treatment based upon screening results alone is not recommended...
  89. ncbi Molecular evidence of coinfection of Borrelia burgdorferi sensu lato, human granulocytic ehrlichiosis agent, and Babesia microti in ticks from northwestern Poland
    B Skotarczak
    Faculty of Biology, Department of Genetics, University of Szczecin, Piastow 40B, 71 065 Szczecin, Poland
    J Parasitol 89:194-6. 2003
    ..l.), human granulocytic ehrlichiosis (HGE) agent, and Babesia microti. Of the 533 processed ticks, 16.7% were positive for B. burgdorferi s. l., 13...
  90. ncbi Human granulocytic ehrlichiosis as a common cause of tick-associated fever in Southeast Sweden: report from a prospective clinical study
    Anneli Bjöersdorff
    Department of Clinical Microbiology, Kalmar County Hospital, Sweden
    Scand J Infect Dis 34:187-91. 2002
    ..illness was prospectively studied in Southeast Sweden in order to assess the occurrence of human granulocytic ehrlichiosis (HGE). Inclusion criteria were fever (> or = 38...
  91. pmc An indirect immunofluorescence assay using a cell culture-derived antigen for detection of antibodies to the agent of human granulocytic ehrlichiosis
    W L Nicholson
    Viral and Rickettsial Zoonoses Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 35:1510-6. 1997
    An indirect immunofluorescence assay for the detection of human antibodies to the agent of human granulocytic ehrlichiosis (HGE) was developed and standardized...
  92. ncbi Experimental infection of lambs with an equine granulocytic Ehrlichia species resembling the agent that causes human granulocytic ehrlichiosis (HGE)
    S Stuen
    Department of Sheep and Goat Research, Norwegian College of Veterinary Medicine, Sandnes, Norway
    Acta Vet Scand 39:491-7. 1998
    ..inoculated with a granulocytic Ehrlichia species originally isolated from a Swedish horse with granulocytic ehrlichiosis (EGE). The 16S rRNA gene sequence of the Swedish Ehrlichia sp...
  93. pmc Superinfection occurs in Anaplasma phagocytophilum infected sheep irrespective of infection phase and protection status
    Snorre Stuen
    Norwegian School of Veterinary Science, Department of Production Animal Clinical Sciences, Sandnes, Norway
    Acta Vet Scand 51:41. 2009
    ..The bacteria may persist in mammalian hosts. Several genetic variants of A. phagocytophilum exist. In the present study, we investigate whether superinfection occurs in the acute and persistent phase of the infection...
  94. ncbi Remission of cunical signs of adult-onset generalized demodicosis after treatment for concurrent babesiosis and/or granulocytic ehrlichiosis in dogs
    W Tarello
    Parasite 14:339-41. 2007
  95. ncbi Acute infection with human monocytic ehrlichiosis: the tip of the iceberg?
    Raphael B Stricker
    South Med J 101:214-5. 2008
  96. ncbi Canine granulocytic ehrlichiosis (CGE) in Italy
    W Tarello
    Airone Veterinary Clinic, Castiglione del Lago Perugia, Italy
    Acta Vet Hung 51:73-90. 2003
    Medical records of thirty-five consecutive cases of canine granulocytic ehrlichiosis (CGE) diagnosed cytologically in Central Italy in 1995-2000 were analysed retrospectively. Tick exposure was reported in 16 dogs (45...
  97. pmc Role of tumor necrosis factor alpha (TNF-alpha) and interleukin-10 in the pathogenesis of severe murine monocytotropic ehrlichiosis: increased resistance of TNF receptor p55- and p75-deficient mice to fatal ehrlichial infection
    Nahed Ismail
    Department of Pathology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0609, USA
    Infect Immun 74:1846-56. 2006
    ..Our data suggest that fatal ehrlichiosis could be a multistep process, where TNF-alpha is not solely responsible for mortality.
  98. pmc Establishment of cloned Anaplasma phagocytophilum and analysis of p44 gene conversion within an infected horse and infected SCID mice
    Quan Lin
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210 1093, USA
    Infect Immun 73:5106-14. 2005
    ..The cloning method developed would facilitate precise analysis of the recombination process and the extent of diversity which the recombination creates in the antigenic repertoire...
  99. pmc Kinetics of antibody response to Ehrlichia canis immunoreactive proteins
    Jere W McBride
    Department of Pathology, Sealy Center for Vaccine Development, and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
    Infect Immun 71:2516-24. 2003
    ..200-kDa glycoproteins gp140 and gp200, respectively, react strongly with serum antibodies from suspect canine ehrlichiosis cases that were positive for E...
  100. pmc Differences in clinical manifestations and hematological and serological responses after experimental infection with genetic variants of Anaplasma phagocytophilum in sheep
    Snorre Stuen
    Department of Sheep and Goat Research, Norwegian School of Veterinary Science, Sandnes, Norway
    Clin Diagn Lab Immunol 10:692-5. 2003
    ..The results of the study indicate a marked difference in clinical manifestation, neutropenia, antibody response, and cross-protection after experimental infection with the two variants of A. phagocytophilum...
  101. pmc Serological investigation of granulocytic Ehrlichia infection in sheep in Norway
    S Stuen
    Norwegian School of Veterinary Science, Department of Sheep and Goat Research, Sandnes, Norway
    Acta Vet Scand 42:331-8. 2001
    ..The association between seropositive flocks and Ixodes infested pasture shows a very high degree of agreement (p < 0.00001). The present study indicates that granulocytic Ehrlichia infection in sheep is underdiagnosed in Norway...

Research Grants83

  1. Tick Midgut Proteins Critical for Borrelia Transmission
    Sukanya Narasimhan; Fiscal Year: 2009
    ..transmit Borrelia burgdorferi (agent of Lyme disease), Anaplasma phagocytophilum (agent of human granulocytic ehrlichiosis) and Babesia microti (agent of human babesiosis) among other pathogens. A. phagocytophilum and B...
  2. Tick Midgut Proteins Critical for Borrelia Transmission
    Sukanya Narasimhan; Fiscal Year: 2010
    ..transmit Borrelia burgdorferi (agent of Lyme disease), Anaplasma phagocytophilum (agent of human granulocytic ehrlichiosis) and Babesia microti (agent of human babesiosis) among other pathogens. A. phagocytophilum and B...
  3. Coinfection of Tick-borne Diseases in Areas of Wisconsin
    DIANE CAPORALE; Fiscal Year: 2001
    ..applicant): Close to 400 human cases of Lyme disease and several --cases of Babesiosis and Human Granulocytic Ehrlichiosis (HGE) are reported in the State of Wisconsin each year...
  4. Landscape Ecology and Mapping of Ehrlichial Pathogens
    MICHAEL WIMBERLY; Fiscal Year: 2006
    ..Two of these diseases are human monocytotropic ehrlichiosis (HME), caused by Ehrlichia chaffeensis; and human granulocytic anaplasmosis (HGA) caused by Anaplasma ..
  5. Landscape Ecology and Mapping of Ehrlichial Pathogens
    MICHAEL WIMBERLY; Fiscal Year: 2005
    ..2 of these diseases are human monocytotropic ehrlichiosis (HME), caused by Ehrlichia chaffeensis; and human granulocytic anaplasmosis (HGA) caused by Anaplasma ..
  6. Infection Dynamics of Ehrlichia chaffeensis
    Andrea Varela Stokes; Fiscal Year: 2005
    ..is to elucidate the infection dynamics of Ehrlichia chaffeensis, the causative agent of human monocytic ehrlichiosis and the most important emerging tick-borne disease in the southeastern United States, in the natural wild ..
  7. Infection Dynamics of Ehrlichia chaffeensis
    Andrea Varela Stokes; Fiscal Year: 2004
    ..is to elucidate the infection dynamics of Ehrlichia chaffeensis, the causative agent of human monocytic ehrlichiosis and the most important emerging tick-borne disease in the southeastern United States, in the natural wild ..
  8. Interactions Between Anaplasma Phagocytophilum and Ixodes Scapularis
    Erol Fikrig; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Human granulocytic anaplasmosis (HGA), previously known as human granulocytic ehrlichiosis, is the second most common tick-borne illness in North America...
  9. EHRLICHIACIDAL MECHANISM BY LEUKOCYTES
    Yasuko Rikihisa; Fiscal Year: 1999
    ..Adapted from the Applicant's Abstract): Recently, tick-borne diseases caused by infection with two new human ehrlichiosis agents: Ehrlichia chaffeensis and human granulocytic ehrlichiosis (HGE) agent are increasingly recognized in ..
  10. Tropical Vector-borne Viral and Rickettsial Infections
    David Walker; Fiscal Year: 2006
    ..felis infections, and human ehrlichiosis in all parts of Mexico...
  11. NOVEL ANTIGENS FOR THE SERODIAGNOSIS OF HUMAN BABESIOSIS
    Raymond Houghton; Fiscal Year: 2000
    ..g. Lyme disease and Human Granulocytic Ehrlichiosis. The estimated market for such a test should be similar to that for Lyme disease testing both in the U.S...
  12. NOVEL ANTIGENS FOR THE SERODIAGNOSIS OF HUMAN BABESIOSIS
    Raymond Houghton; Fiscal Year: 1999
    ..g. Lyme disease and Human Granulocytic Ehrlichiosis. The estimated market for such a test should be similar to that for Lyme disease testing both in the U.S...
  13. Tropical Vector-borne Viral and Rickettsial Infections
    David Walker; Fiscal Year: 2005
    ..felis infections, and human ehrlichiosis in all parts of Mexico...
  14. Tropical Vector-borne Viral and Rickettsial Infections
    David Walker; Fiscal Year: 2004
    ..felis infections, and human ehrlichiosis in all parts of Mexico...
  15. NOVEL ANTIGENS FOR THE SERODIAGNOSIS OF HUMAN BABESIOSIS
    Raymond Houghton; Fiscal Year: 2001
    ..g. Lyme disease and Human Granulocytic Ehrlichiosis. The estimated market for such a test should be similar to that for Lyme disease testing both in the U.S...
  16. Tropical Vector-borne Viral and Rickettsial Infections
    David Walker; Fiscal Year: 2003
    ..felis infections, and human ehrlichiosis in all parts of Mexico...
  17. HEALTH BURDEN OF CO INFECTING DEER ASSOCIATED ZOONOTIC CNS DISEASE
    Peter Krause; Fiscal Year: 1999
    ..Although we shall focus on the agents of Lyme disease, babesiosis, human granulocytic ehrlichiosis and TBE-group arboviruses, we shall seek to document the presence of other tick-borne microbes and the ..
  18. Vaccination Against Ixodes scapularis Tick Bites
    Raymond Koski; Fiscal Year: 2001
    ..burgdorferi, the agent of human granulocytic ehrlichiosis, and Babesia microti...
  19. GENE EXPRESSION BY HUMAN GRANULOCYTIC EHRLICHIOSIS AG
    Yasuko Rikihisa; Fiscal Year: 2003
    DESCRIPTION (Adapted from Applicant's Abstract): Human granulocytic ehrlichiosis (HGE) is a new tick-borne zoonosis that is increasingly recognized as a threat to public health in the United States...
  20. GENE EXPRESSION BY HUMAN GRANULOCYTIC EHRLICHIOSIS AG
    Yasuko Rikihisa; Fiscal Year: 2001
    DESCRIPTION (Adapted from Applicant's Abstract): Human granulocytic ehrlichiosis (HGE) is a new tick-borne zoonosis that is increasingly recognized as a threat to public health in the United States...
  21. GENE EXPRESSION BY HUMAN GRANULOCYTIC EHRLICHIOSIS AG
    Yasuko Rikihisa; Fiscal Year: 2000
    DESCRIPTION (Adapted from Applicant's Abstract): Human granulocytic ehrlichiosis (HGE) is a new tick-borne zoonosis that is increasingly recognized as a threat to public health in the United States...
  22. GENE EXPRESSION BY HUMAN GRANULOCYTIC EHRLICHIOSIS AG
    Yasuko Rikihisa; Fiscal Year: 2002
    DESCRIPTION (Adapted from Applicant's Abstract): Human granulocytic ehrlichiosis (HGE) is a new tick-borne zoonosis that is increasingly recognized as a threat to public health in the United States...
  23. MOLECULAR MECHANISMS OF MSP2 VARIATION IN RICKETTSIAE
    Anthony Barbet; Fiscal Year: 2007
    ..to improve our understanding of the mechanisms of pathogenesis of tick- borne rickettsial pathogens that cause ehrlichiosis and anaplasmosis of humans and animals. These pathogens efficiently utilize a small genome (<1...
  24. MOLECULAR MECHANISMS OF MSP2 VARIATION IN RICKETTSIAE
    Anthony Barbet; Fiscal Year: 2006
    ..to improve our understanding of the mechanisms of pathogenesis of tick borne rickettsial pathogens that cause ehrlichiosis and anaplasmosis of humans and animals. These pathogens efficiently utilize a small genome (<1...
  25. MOLECULAR MECHANISMS OF MSP2 VARIATION IN RICKETTSIAE
    Anthony Barbet; Fiscal Year: 2003
    ..to improve our understanding of the mechanisms of pathogenesis of tick borne rickettsial pathogens that cause ehrlichiosis and anaplasmosis of humans and animals. These pathogens efficiently utilize a small genome (<1...
  26. Vaccination Against Ixodes scapularis Tick Bites
    Michel Ledizet; Fiscal Year: 2002
    ..burgdorferi. This tick also transmits the agents of human granulocytic ehrlichiosis and babesiosis. The purpose of this project is to develop an anti-I...
  27. Vaccination Against Ixodes scapularis Tick Bites
    Michel Ledizet; Fiscal Year: 2003
    ..burgdorferi. This tick also transmits the agents of human granulocytic ehrlichiosis and babesiosis. The purpose of this project is to develop an anti-I...
  28. COMPARISON OF 3 HUMAN EHRLICHIOSIS GENOME SEQUENCES
    Yasuko Rikihisa; Fiscal Year: 2000
    ..vector-borne zoonoses in the United States, including a new granulocytotropic ehrlichia, the human granulocytic ehrlichiosis (HGE) agent, and Ehrlichia chaffeensis, a new monocytotropic ehrlichia causes human monocytic ehrlichiosis. E...
  29. Spatially-explicit mathematical model of human monocytic ehrlichiosis
    HOLLY GAFF; Fiscal Year: 2009
    ..develop, analyze and apply a spatially-explicit mathematical model for the tick-borne disease, human monocytic ehrlichiosis (causitive agent: Ehrlichia chaffeensis sp.)...
  30. Genetic Determinants of Anaplasma Transmission
    SUSAN NOH; Fiscal Year: 2004
    ..within the genus Anaplasma (order Rickettsiales) cause human and animal diseases including human granulocytic ehrlichiosis (HGE), equine ehrlichiosis, and bovine and ovine anaplasmosis...
  31. Spatially-explicit mathematical model of human monocytic ehrlichiosis
    HOLLY GAFF; Fiscal Year: 2010
    ..develop, analyze and apply a spatially-explicit mathematical model for the tick-borne disease, human monocytic ehrlichiosis (causitive agent: Ehrlichia chaffeensis sp.)...
  32. Genetic Determinants of Anaplasma Transmission
    SUSAN NOH; Fiscal Year: 2002
    ..within the genus Anaplasma (order Rickettsiales) cause human and animal diseases including human granulocytic ehrlichiosis (HGE), equine ehrlichiosis, and bovine and ovine anaplasmosis...
  33. Genetic Determinants of Anaplasma Transmission
    SUSAN NOH; Fiscal Year: 2003
    ..within the genus Anaplasma (order Rickettsiales) cause human and animal diseases including human granulocytic ehrlichiosis (HGE), equine ehrlichiosis, and bovine and ovine anaplasmosis...
  34. HEALTH BURDERN OF COINFECTING DEER ASSOCIATED ZOONOSES
    Peter Krause; Fiscal Year: 2001
    ..Although we shall focus on the agents of Lyme disease, babesiosis, human granulocytic ehrlichiosis and TBE-group arboviruses, we shall seek to document the presence of other tick-borne microbes and the ..
  35. HEALTH BURDERN OF COINFECTING DEER ASSOCIATED ZOONOSES
    Peter Krause; Fiscal Year: 2000
    ..Although we shall focus on the agents of Lyme disease, babesiosis, human granulocytic ehrlichiosis and TBE-group arboviruses, we shall seek to document the presence of other tick-borne microbes and the ..
  36. HEALTH BURDERN OF COINFECTING DEER ASSOCIATED ZOONOSES
    Peter Krause; Fiscal Year: 1999
    ..Although we shall focus on the agents of Lyme disease, babesiosis, human granulocytic ehrlichiosis and TBE-group arboviruses, we shall seek to document the presence of other tick-borne microbes and the ..
  37. Spatially-explicit mathematical model of human monocytic ehrlichiosis
    HOLLY GAFF; Fiscal Year: 2007
    ..develop, analyze and apply a spatially-explicit mathematical model for the tick-borne disease, human monocytic ehrlichiosis (causitive agent: Ehrlichia chaffeensis sp.)...
  38. Spatially-explicit mathematical model of human monocytic ehrlichiosis
    HOLLY GAFF; Fiscal Year: 2007
    ..develop, analyze and apply a spatially-explicit mathematical model for the tick-borne disease, human monocytic ehrlichiosis (causitive agent: Ehrlichia chaffeensis sp.)...
  39. EHRLICHIA CHAFFEENSIS SURFACE PROTEINS
    David Walker; Fiscal Year: 2000
    ..mechanisms of protective immunity against Ehrlichia chaffeensis, the causative agent of human monocytotropic ehrlichiosis (HME)...
  40. EHRLICHIA CHAFFEENSIS SURFACE PROTEINS
    David Walker; Fiscal Year: 2000
    ..mechanisms of protective immunity against Ehrlichia chaffeensis, the causative agent of human monocytotropic ehrlichiosis (HME)...
  41. Prevention of Lyme Disease in Connecticut
    Matthew Cartter; Fiscal Year: 2004
    ..activities is to reduce the incidence of Lyme disease and other tick-borne diseases in including babesiosis and ehrlichiosis. This proposal will evaluate the effectiveness of the currently available measures to reduce the risk of LD in ..
  42. Prevention of Lyme Disease in Connecticut
    Matthew Cartter; Fiscal Year: 2007
    ..activities is to reduce the incidence of Lyme disease and other tick-borne diseases in including babesiosis and ehrlichiosis. This proposal will evaluate the effectiveness of the currently available measures to reduce the risk of LD in ..
  43. Prevention of Lyme Disease in Connecticut
    Matthew Cartter; Fiscal Year: 2006
    ..activities is to reduce the incidence of Lyme disease and other tick-borne diseases in including babesiosis and ehrlichiosis. This proposal will evaluate the effectiveness of the currently available measures to reduce the risk of LD in ..
  44. Prevention of Lyme Disease in Connecticut
    Matthew Cartter; Fiscal Year: 2005
    ..activities is to reduce the incidence of Lyme disease and other tick-borne diseases in including babesiosis and ehrlichiosis. This proposal will evaluate the effectiveness of the currently available measures to reduce the risk of LD in ..
  45. TRANSMISSION OF GRANULOCYTIC EHRLICHIOSIS
    Sam Telford; Fiscal Year: 2000
    We propose to determine whether the agent of human granulocytic ehrlichiosis in coastal New England is cotransmitted with those of Lyme disease and human babesiosis...
  46. PATHOGENESIS OF HUMAN GRANULOCYTIC EHRLICHIOSIS
    JONATHAN RAVDIN; Fiscal Year: 2000
    DESCRIPTION (Adapted from the applicant's abstract): Human granulocytic ehrlichiosis (HGE) is an acute febrile illness described 2 years ago in Minnesota and Wisconsin and now rapidly emerging in areas infested by its likely vector, ..
  47. Antigenic variation of Anaplasma marginale
    PATRICK MEEUS; Fiscal Year: 2003
    ..pathogen, is closely related to Anaplasma (Ehrlichia) phagocytophila, the causative agent of human granulocytic ehrlichiosis. Investigations of bovine anaplasmosis offer a unique opportunity to study the mechanisms of antigenic ..
  48. PATHOGENESIS OF HUMAN GRANULOCYTIC EHRLICHIOSIS
    JONATHAN RAVDIN; Fiscal Year: 1999
    DESCRIPTION (Adapted from the applicant's abstract): Human granulocytic ehrlichiosis (HGE) is an acute febrile illness described 2 years ago in Minnesota and Wisconsin and now rapidly emerging in areas infested by its likely vector, ..
  49. TRANSMISSION OF GRANULOCYTIC EHRLICHIOSIS
    Sam Telford; Fiscal Year: 1999
    We propose to determine whether the agent of human granulocytic ehrlichiosis in coastal New England is cotransmitted with those of Lyme disease and human babesiosis...
  50. PATHOGENESIS OF HUMAN GRANULOCYTIC EHRLICHIOSIS
    Ulrike Munderloh; Fiscal Year: 2001
    DESCRIPTION (Adapted from the applicant's abstract): Human granulocytic ehrlichiosis (HGE) is an acute febrile illness described 2 years ago in Minnesota and Wisconsin and now rapidly emerging in areas infested by its likely vector, ..
  51. Cellular Immunity Against Ehrlichia chaffeensis
    ROMAN GANTA; Fiscal Year: 2003
    Human ehrlichiosis is caused by three agents including Ehrlichia chaffeensis, Anaplasma phagocytophila and by E. ewengii...
  52. Virulence and Immunity of Granulocytic Ehrlichiae
    JOHN DUMLER; Fiscal Year: 2002
    Human granulocytic ehrlichiosis (HGE) is an emerging tick-borne infection caused by Anaplasma (Ehrlichia) phagocytophila, an obligate intracellular bacteria that infects neutrophils...
  53. Development of a multivalent vaccine for mouse reservoirs of deer tick pathogens
    Linden Hu; Fiscal Year: 2009
    ..S.-- Lyme disease, Babesiosis and human granulocytic ehrlichiosis. The incidence of all three diseases has been increasing over the last decade...
  54. Development of a multivalent vaccine for mouse reservoirs of deer tick pathogens
    Linden T Hu; Fiscal Year: 2010
    ..S.-- Lyme disease, Babesiosis and human granulocytic ehrlichiosis. The incidence of all three diseases has been increasing over the last decade...
  55. Transmission of Ehrlichia chaffeensis by Adult Ticks
    ROGER STICH; Fiscal Year: 2002
    DESCRIPTION (provided by the applicant): Approaches to the control of human monocytic ehrlichiosis (HME), the most prevalent zoonotic ehrlichial disease reported in the USA to date, rely on better understanding of interactions between ..
  56. DEVELOPMENT OF PCR BASED ASSAY FOR BABESIOSIS
    BITA NAKHAI; Fiscal Year: 1999
    ..S. Although Lyme Disease is the most prevalent vector- borne disease, two additional diseases, Babesiosis and Ehrlichiosis are transmitted by the same tick vector and share the same host reservoir...
  57. Characterization of Anaplasma phagocytophilum adhesins
    JASON CARLYON; Fiscal Year: 2009
    Human granulocytic anaplasmosis (HGA;formerly human granulocytic ehrlichiosis) is an emerging and potentially fatal disease and the second most common tick-borne infection in the United States...
  58. Characterization of Anaplasma phagocytophilum adhesins
    Jason A Carlyon; Fiscal Year: 2010
    Human granulocytic anaplasmosis (HGA;formerly human granulocytic ehrlichiosis) is an emerging and potentially fatal disease and the second most common tick-borne infection in the United States...
  59. Characterization of Anaplasma phagocytophilum adhesins
    JASON CARLYON; Fiscal Year: 2009
    Human granulocytic anaplasmosis (HGA;formerly human granulocytic ehrlichiosis) is an emerging and potentially fatal disease and the second most common tick-borne infection in the United States...
  60. MOLECULAR MECHANISMS OF MSP2 VARIATION IN RICKETTSIAE
    Anthony Barbet; Fiscal Year: 1999
    ..ehrlichial infections of humans caused by Ehrlichia chaffeensis and the causative agent of human granulocytic ehrlichiosis as well as E. canis, E. equi, Cowdria ruminantium and Anaplasma marginale infections of animals...
  61. Characterization of Anaplasma phagocytophilum adhesins
    JASON CARLYON; Fiscal Year: 2009
    Human granulocytic anaplasmosis (HGA;formerly human granulocytic ehrlichiosis) is an emerging and potentially fatal disease and the second most common tick-borne infection in the United States...
  62. Characterization of Anaplasma phagocytophilum adhesins
    JASON CARLYON; Fiscal Year: 2007
    Human granulocytic anaplasmosis (HGA; formerly human granulocytic ehrlichiosis) is an emerging and potentially fatal disease and the second most common tick-borne infection in the United States...
  63. MOLECULAR MECHANISMS OF MSP2 VARIATION IN RICKETTSIAE
    Anthony Barbet; Fiscal Year: 2000
    ..ehrlichial infections of humans caused by Ehrlichia chaffeensis and the causative agent of human granulocytic ehrlichiosis as well as E. canis, E. equi, Cowdria ruminantium and Anaplasma marginale infections of animals...
  64. Characterization of Anaplasma phagocytophilum adhesins
    JASON CARLYON; Fiscal Year: 2009
    Human granulocytic anaplasmosis (HGA;formerly human granulocytic ehrlichiosis) is an emerging and potentially fatal disease and the second most common tick-borne infection in the United States...
  65. Characterization of Anaplasma phagocytophilum adhesins
    Jason A Carlyon; Fiscal Year: 2010
    Human granulocytic anaplasmosis (HGA;formerly human granulocytic ehrlichiosis) is an emerging and potentially fatal disease and the second most common tick-borne infection in the United States...
  66. MOLECULAR MECHANISMS OF MSP2 VARIATION IN RICKETTSIAE
    Anthony Barbet; Fiscal Year: 2002
    ..ehrlichial infections of humans caused by Ehrlichia chaffeensis and the causative agent of human granulocytic ehrlichiosis as well as E. canis, E. equi, Cowdria ruminantium and Anaplasma marginale infections of animals...
  67. MOLECULAR MECHANISMS OF MSP2 VARIATION IN RICKETTSIAE
    Anthony Barbet; Fiscal Year: 2001
    ..ehrlichial infections of humans caused by Ehrlichia chaffeensis and the causative agent of human granulocytic ehrlichiosis as well as E. canis, E. equi, Cowdria ruminantium and Anaplasma marginale infections of animals...
  68. MOLECULAR MECHANISMS OF MSP2 VARIATION IN RICKETTSIAE
    Anthony Barbet; Fiscal Year: 2000
    ..ehrlichial infections of humans caused by Ehrlichia chaffeensis and the causative agent of human granulocytic ehrlichiosis as well as E. canis, E. equi, Cowdria ruminantium and Anaplasma marginale infections of animals...
  69. Inhibition of NADPH oxidase by Anaplasma phagocytophila
    JASON CARLYON; Fiscal Year: 2006
    Human granulocytic ehrlichiosis (HGE) is an emerging infection of the blood that results in leukopenia and thrombocytopenia...
  70. Inhibition of NADPH oxidase by Anaplasma phagocytophila
    JASON CARLYON; Fiscal Year: 2005
    Human granulocytic ehrlichiosis (HGE) is an emerging infection of the blood that results in leukopenia and thrombocytopenia...
  71. Inhibition of NADPH oxidase by Anaplasma phagocytophila
    JASON CARLYON; Fiscal Year: 2004
    Human granulocytic ehrlichiosis (HGE) is an emerging infection of the blood that results in leukopenia and thrombocytopenia...
  72. Inhibition of NADPH oxidase by Anaplasma phagocytophila
    JASON CARLYON; Fiscal Year: 2003
    Human granulocytic ehrlichiosis (HGE) is an emerging infection of the blood that results in leukopenia and thrombocytopenia...
  73. Inhibition of NADPH oxidase by Anaplasma phagocytophila
    JASON CARLYON; Fiscal Year: 2007
    Human granulocytic ehrlichiosis (HGE) is an emerging infection of the blood that results in leukopenia and thrombocytopenia...
  74. Subverted host cell signaling by AnkA in Anaplasma phagocytophilum infection
    Jacob Ijdo; Fiscal Year: 2009
    Anaplasma phagocytophilum, is a human pathogen that infects neutrophils and causes Human Granulocytic Ehrlichiosis. In the Unites States it is the second most common tick-associated infection, only surpassed by Lyme disease...
  75. Subverted host cell signaling by AnkA in Anaplasma phagocytophilum infection
    Jacob W IJdo; Fiscal Year: 2010
    Anaplasma phagocytophilum, is a human pathogen that infects neutrophils and causes Human Granulocytic Ehrlichiosis. In the Unites States it is the second most common tick-associated infection, only surpassed by Lyme disease...
  76. HUMAN GRANULOCYTIC EHRLICHIOSIS: NORTH CENTRAL U.S.
    Russell Johnson; Fiscal Year: 2003
    DESCRIPTION: Human granulocytic ehrlichiosis (HGE) is an emerging tick-borne acute febrile illness...
  77. Immunity directed against MSP 2 during anaplasmosis
    Jeffrey Abbott; Fiscal Year: 2004
    ..phagocytophila, the causative agent of human granulocytic ehrlichiosis (HGE)...
  78. HUMAN GRANULOCYTIC EHRLICHIOSIS: NORTH CENTRAL U.S.
    Russell Johnson; Fiscal Year: 2005
    DESCRIPTION: Human granulocytic ehrlichiosis (HGE) is an emerging tick-borne acute febrile illness...
  79. Immunity directed against MSP 2 during anaplasmosis
    Jeffrey Abbott; Fiscal Year: 2002
    ..phagocytophila, the causative agent of human granulocytic ehrlichiosis (HGE)...
  80. HUMAN GRANULOCYTIC EHRLICHIOSIS: NORTH CENTRAL U.S.
    Russell Johnson; Fiscal Year: 2002
    DESCRIPTION: Human granulocytic ehrlichiosis (HGE) is an emerging tick-borne acute febrile illness...
  81. Immunity directed against MSP 2 during anaplasmosis
    Jeffrey Abbott; Fiscal Year: 2004
    ..phagocytophila, the causative agent of human granulocytic ehrlichiosis (HGE)...
  82. HUMAN GRANULOCYTIC EHRLICHIOSIS: NORTH CENTRAL U.S.
    Russell Johnson; Fiscal Year: 2001
    DESCRIPTION: Human granulocytic ehrlichiosis (HGE) is an emerging tick-borne acute febrile illness...
  83. TICK-BORNE DISEASE PANEL TEST
    Andrew Levin; Fiscal Year: 2000
    ..membrane immunoassay will simultaneously detect antibodies to the agents of Lyme disease, Human Granulocytic Ehrlichiosis, Human Monocytic Ehrlichiosis, Babesiosis, and Rocky Mountain Spotted Fever...