dengue hemorrhagic fever

Summary

Summary: A distinct and virulent form of DENGUE characterized by thrombocytopenia and hemoconcentration (grades I and II) and distinguished by a positive tourniquet test. When accompanied by circulatory failure and shock (grades III and IV), it is called dengue shock syndrome. (From Dorland, 28th ed)

Top Publications

  1. ncbi Predictive value of simple clinical and laboratory variables for dengue hemorrhagic fever in adults
    Vernon J Lee
    Department of Clinical Epidemiology, Tan Tock Seng Hospital, Singapore
    J Clin Virol 42:34-9. 2008
  2. pmc Dengue and dengue hemorrhagic fever
    D J Gubler
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
    Clin Microbiol Rev 11:480-96. 1998
  3. ncbi Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century
    Duane J Gubler
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Dept of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA
    Trends Microbiol 10:100-3. 2002
  4. ncbi High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue N, Worcester, MA 01655, USA
    J Infect Dis 186:1165-8. 2002
  5. ncbi Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever
    Juthathip Mongkolsapaya
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DS, UK
    Nat Med 9:921-7. 2003
  6. ncbi Serotype-specific dengue virus circulation and dengue disease in Bangkok, Thailand from 1973 to 1999
    Ananda Nisalak
    Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Am J Trop Med Hyg 68:191-202. 2003
  7. ncbi Differing influences of virus burden and immune activation on disease severity in secondary dengue-3 virus infections
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Infect Dis 185:1213-21. 2002
  8. ncbi Clinical characteristics, risk factors, and outcomes in adults experiencing dengue hemorrhagic fever complicated with acute renal failure
    Ing Kit Lee
    Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien, Taiwan
    Am J Trop Med Hyg 80:651-5. 2009
  9. ncbi Secondary infection as a risk factor for dengue hemorrhagic fever/dengue shock syndrome: an historical perspective and role of antibody-dependent enhancement of infection
    Maria G Guzman
    Institute of Tropical Medicine Pedro Kouri, Havana, Cuba
    Arch Virol 158:1445-59. 2013
  10. pmc A prospective nested case-control study of Dengue in infants: rethinking and refining the antibody-dependent enhancement dengue hemorrhagic fever model
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts, United States
    PLoS Med 6:e1000171. 2009

Detail Information

Publications303 found, 100 shown here

  1. ncbi Predictive value of simple clinical and laboratory variables for dengue hemorrhagic fever in adults
    Vernon J Lee
    Department of Clinical Epidemiology, Tan Tock Seng Hospital, Singapore
    J Clin Virol 42:34-9. 2008
    ..Singapore experienced its worst dengue outbreak in 30 years in 2004, with 9459 notified cases, of which 83% were hospitalized...
  2. pmc Dengue and dengue hemorrhagic fever
    D J Gubler
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
    Clin Microbiol Rev 11:480-96. 1998
    ..the development of hyperendemicity (the cocirculation of multiple serotypes), and the emergence of dengue hemorrhagic fever in new geographic regions...
  3. ncbi Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century
    Duane J Gubler
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Dept of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA
    Trends Microbiol 10:100-3. 2002
    Dengue fever/dengue hemorrhagic fever is now one of the most important public health problems in tropical developing countries and also has major economic and societal consequences.
  4. ncbi High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue N, Worcester, MA 01655, USA
    J Infect Dis 186:1165-8. 2002
    ..spectrum of clinical illness ranging from a mild undifferentiated febrile illness to dengue fever (DF) to dengue hemorrhagic fever (DHF), a potentially life-threatening disease...
  5. ncbi Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever
    Juthathip Mongkolsapaya
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DS, UK
    Nat Med 9:921-7. 2003
    ..Four major serotypes of dengue virus have been characterized, and epidemiological evidence shows that dengue hemorrhagic fever (DHF), the more serious manifestation of the disease, occurs more frequently upon reinfection with a ..
  6. ncbi Serotype-specific dengue virus circulation and dengue disease in Bangkok, Thailand from 1973 to 1999
    Ananda Nisalak
    Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Am J Trop Med Hyg 68:191-202. 2003
    ..DEN-3 was the most frequent serotype in primary dengue (49% of all isolates), DEN-2 in secondary and in dengue hemorrhagic fever (37% and 35%, respectively)...
  7. ncbi Differing influences of virus burden and immune activation on disease severity in secondary dengue-3 virus infections
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Infect Dis 185:1213-21. 2002
    b>Dengue hemorrhagic fever (DHF), the most severe form of illness following infection with a dengue virus, is characterized by plasma leakage, thrombocytopenia, and hepatic inflammation...
  8. ncbi Clinical characteristics, risk factors, and outcomes in adults experiencing dengue hemorrhagic fever complicated with acute renal failure
    Ing Kit Lee
    Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien, Taiwan
    Am J Trop Med Hyg 80:651-5. 2009
    ..3%) among 304 hospitalized adults with dengue hemorrhagic fever (DHF), and 6 (60%) of the 10 patients with ARF died, whereas all 294 patients without ARF (controls) ..
  9. ncbi Secondary infection as a risk factor for dengue hemorrhagic fever/dengue shock syndrome: an historical perspective and role of antibody-dependent enhancement of infection
    Maria G Guzman
    Institute of Tropical Medicine Pedro Kouri, Havana, Cuba
    Arch Virol 158:1445-59. 2013
    ..a second heterologous dengue virus (DENV) infection as a principal risk factor for severe dengue disease (dengue hemorrhagic fever/dengue shock syndrome, DHF/DSS)...
  10. pmc A prospective nested case-control study of Dengue in infants: rethinking and refining the antibody-dependent enhancement dengue hemorrhagic fever model
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts, United States
    PLoS Med 6:e1000171. 2009
    b>Dengue hemorrhagic fever (DHF) is the severe and life-threatening syndrome that can develop after infection with any one of the four dengue virus (DENV) serotypes...
  11. ncbi Dengue and dengue haemorrhagic fever
    J G Rigau-Perez
    Dengue Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, San Juan, Puerto Rico 00921 3200, USA
    Lancet 352:971-7. 1998
    ..Biological and social research are essential to develop effective mosquito control, medications to reduce capillary leakage, and a safe tetravalent vaccine...
  12. pmc Murine model for dengue virus-induced lethal disease with increased vascular permeability
    Sujan Shresta
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    J Virol 80:10208-17. 2006
    Lack of an appropriate animal model for dengue virus (DEN), which causes dengue fever and dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), has impeded characterization of the mechanisms underlying the disease pathogenesis...
  13. pmc Fatal dengue hemorrhagic fever in adults: emphasizing the evolutionary pre-fatal clinical and laboratory manifestations
    Ing Kit Lee
    Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
    PLoS Negl Trop Dis 6:e1532. 2012
    A better description of the clinical and laboratory manifestations of fatal patients with dengue hemorrhagic fever (DHF) is important in alerting clinicians of severe dengue and improving management.
  14. ncbi Classifying dengue: a review of the difficulties in using the WHO case classification for dengue haemorrhagic fever
    Shibani Bandyopadhyay
    Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Trop Med Int Health 11:1238-55. 2006
    ..Dengue has extended to different tropical areas and older age groups. Variations from the original description of dengue manifestations are being reported...
  15. ncbi Of cascades and perfect storms: the immunopathogenesis of dengue haemorrhagic fever-dengue shock syndrome (DHF/DSS)
    Tikki Pang
    Department of Research Policy and Cooperation, World Health Organization, Geneva, Switzerland
    Immunol Cell Biol 85:43-5. 2007
    ....
  16. ncbi Outcome of dengue hemorrhagic fever-caused acute kidney injury in Thai children
    Kamolwish Laoprasopwattana
    Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand
    J Pediatr 157:303-9. 2010
    To examine the outcome of acute kidney injury (AKI) in children with dengue hemorrhagic fever (DHF), the cause(s) of AKI, and the risk of AKI and fatality.
  17. ncbi Dengue in travelers
    Annelies Wilder-Smith
    Travellers Health and Vaccination Centre, Tan Tock Seng Hospital, Singapore
    N Engl J Med 353:924-32. 2005
  18. ncbi Alteration of cytokines and chemokines during febrile episodes associated with endothelial cell damage and plasma leakage in dengue hemorrhagic fever
    Punnee Butthep
    Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Pediatr Infect Dis J 31:e232-8. 2012
    ..The study was designed to demonstrate the alteration of cytokines and chemokines in dengue-infected patients during febrile episodes...
  19. pmc Diabetes with hypertension as risk factors for adult dengue hemorrhagic fever in a predominantly dengue serotype 2 epidemic: a case control study
    Junxiong Pang
    Infectious Diseases, Genome Institute of Singapore, Singapore, Singapore
    PLoS Negl Trop Dis 6:e1641. 2012
    b>Dengue hemorrhagic fever (DHF) is a severe form of dengue, characterized by bleeding and plasma leakage. A number of DHF risk factors had been suggested...
  20. ncbi Antibodies determine virulence in dengue
    Scott B Halstead
    Supportive Research and Development Program, Pediatric Dengue Vaccine Initiative, Bethesda, Maryland 20852, USA
    Ann N Y Acad Sci 1171:E48-56. 2009
    Four dengue viruses (DENV) cause syndromes that are self-limited or severe. The severe syndrome, dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), characterized by sudden vascular permeability, is not caused by inherently virulent ..
  21. pmc Dengue hemorrhagic fever: the sensitivity and specificity of the world health organization definition for identification of severe cases of dengue in Thailand, 1994-2005
    Anon Srikiatkhachorn
    University of Massachusetts Medical School, Worcester, MA 01655, USA
    Clin Infect Dis 50:1135-43. 2010
    ..usually classified according to the World Health Organization (WHO) guidelines into dengue fever (DF) and dengue hemorrhagic fever (DHF). The ability of these guidelines to categorize severe dengue illness has recently been questioned.
  22. ncbi Dengue hemorrhagic fever in infants: a study of clinical and cytokine profiles
    Thanh Hung Nguyen
    Department of Dengue Hemorrhagic Fever, Children s Hospital No 1 Ho Chi Minh City, Vietnam
    J Infect Dis 189:221-32. 2004
    A prospective study of clinical and cytokine profiles of 107 infants with dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) was conducted...
  23. ncbi Clinical and laboratory characteristics and risk factors for fatality in elderly patients with dengue hemorrhagic fever
    Ing Kit Lee
    Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien, Taiwan
    Am J Trop Med Hyg 79:149-53. 2008
    ..and laboratory characteristics and to identify risk factor(s) for fatality in elderly patients with dengue hemorrhagic fever (DHF), 66 elderly (age > or = 65 years) and 241 non-elderly adults (age, 19-64 years) with DHF were ..
  24. ncbi Dengue and dengue hemorrhagic fever among adults: clinical outcomes related to viremia, serotypes, and antibody response
    Adriana O Guilarde
    Instituto de Patologia Tropical e Saude Publica, Universidade Federal de Goias, Brazil
    J Infect Dis 197:817-24. 2008
    ..In Brazil, the disease burden predominantly affects adults, with an increasing trend toward progression to dengue hemorrhagic fever (DHF) noted.
  25. ncbi Dengue: an update
    Maria G Guzman
    Virology Department, PAHO WHO Collaborating Center for Viral Diseases, Pedro Kouri Tropical Medicine Institute, Autopista Novia del Mediodia, Km 6, PO Box Marianao 13, Ciudad Habana, Cuba
    Lancet Infect Dis 2:33-42. 2002
    ..We describe the status of vaccine development and emphasise that the only alternative that we have today to control the disease is through control of its vector Aedes aegypti...
  26. ncbi Analysis of repeat hospital admissions for dengue to estimate the frequency of third or fourth dengue infections resulting in admissions and dengue hemorrhagic fever, and serotype sequences
    Robert V Gibbons
    Department of Virology, United States Army Medical Component Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Am J Trop Med Hyg 77:910-3. 2007
    ..In fact, the greatest risk for dengue hemorrhagic fever (DHF) is with a second DENV serotype exposure...
  27. pmc Dengue and dengue hemorrhagic fever, Brazil, 1981-2002
    Joao Bosco Siqueira
    Ministry of Health, Quadra 4, Bloco N, 7o andar Sala 715, 70 070 040 Brasília, DF, Brazil
    Emerg Infect Dis 11:48-53. 2005
    ..We analyzed trends of dengue and dengue hemorrhagic fever (DHF) from the early 1980s to 2002 by using surveillance data from the Brazilian Ministry of Health...
  28. pmc An in-depth analysis of original antigenic sin in dengue virus infection
    Claire M Midgley
    Department of Medicine, Hammersmith Hospital Campus, Imperial College London, London, United Kingdom
    J Virol 85:410-21. 2011
    ..Dengue infection, although frequently mild, can lead to dengue hemorrhagic fever (DHF) which can be life threatening...
  29. pmc Both virus and tumor necrosis factor alpha are critical for endothelium damage in a mouse model of dengue virus-induced hemorrhage
    Hsuen Chin Chen
    Graduate Institute of Immunology, National Taiwan University College of Medicine, No 1 Jen Ai Road, Section 1, Taipei 10051, Taiwan, Republic of China
    J Virol 81:5518-26. 2007
    ..This finding highlights the contribution of the innate immune response to dengue hemorrhage...
  30. ncbi Dengue and dengue hemorrhagic fever in the Americas: lessons and challenges
    Maria G Guzman
    Virology Department, PAHO WHO Collaborating Center for Viral Diseases, Pedro Kouri Tropical Medicine Institute, Autopista Novia del Mediodia, Km 6 P O Box Marianao 13, Havana, Cuba
    J Clin Virol 27:1-13. 2003
    The incidence of dengue and dengue hemorrhagic fever (DF/DHF) has increased significantly over the last decades. Yearly, an estimated 50-100 million cases of DF and about 250000-500000 cases of DHF occur worldwide...
  31. pmc Decision tree algorithms predict the diagnosis and outcome of dengue fever in the early phase of illness
    Lukas Tanner
    Novartis Institute for Tropical Diseases, Singapore
    PLoS Negl Trop Dis 2:e196. 2008
    ..Here we report the identification of algorithms that differentiate dengue from other febrile illnesses in the primary care setting and predict severe disease in adults...
  32. pmc Dengue: an escalating problem
    Robert V Gibbons
    Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    BMJ 324:1563-6. 2002
  33. ncbi Dengue hemorrhagic fever with special emphasis on immunopathogenesis
    Ichiro Kurane
    Department of Virology 1, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Comp Immunol Microbiol Infect Dis 30:329-40. 2007
    ..Dengue virus infection can be asymptomatic or causes two forms of illness, dengue fever (DF) and dengue hemorrhagic fever (DHF), which is the severe form of dengue illness and often fatal...
  34. ncbi Dengue hemorrhagic fever and shock syndromes
    Suchitra Ranjit
    Pediatric Intensive Care Unit, Apollo Children s Hospital, Chennai, India
    Pediatr Crit Care Med 12:90-100. 2011
    ..Dengue, a leading cause of childhood mortality in Asia and South America, is the most rapidly spreading and important arboviral disease in the world and has a geographic distribution of > 100 countries...
  35. pmc A three-component biomarker panel for prediction of dengue hemorrhagic fever
    Allan R Brasier
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA
    Am J Trop Med Hyg 86:341-8. 2012
    Dengue virus infections are a major cause of morbidity in tropical countries. Early detection of dengue hemorrhagic fever (DHF) may help identify individuals that would benefit from intensive therapy...
  36. pmc Validation of probability equation and decision tree in predicting subsequent dengue hemorrhagic fever in adult dengue inpatients in Singapore
    Tun L Thein
    Communicable Disease Center, Tan Tock Seng Hospital, Singapore
    Am J Trop Med Hyg 85:942-5. 2011
    ..predominantly dengue serotype 1 hospitalized adult dengue patients in 2004 to predict progression to dengue hemorrhagic fever (DHF), applied in our clinic since March 2007...
  37. ncbi Multiple dengue serotypes and high frequency of dengue hemorrhagic fever at two tertiary care hospitals in Lahore during the 2008 dengue virus outbreak in Punjab, Pakistan
    Malik Asif Humayoun
    Department of Medicine, Allama Iqbal Medical College and Jinnah Hospital, Maulana Shabbir Ahmed Usmani Road, Lahore, Punjab, Pakistan
    Int J Infect Dis 14:e54-9. 2010
    ..The objective of this study was to investigate the clinical characteristics of patients with dengue viral infection during the 2008 outbreak in Lahore in order to better understand the clinical pattern and severity of disease in Lahore...
  38. pmc Protective and enhancing HLA alleles, HLA-DRB1*0901 and HLA-A*24, for severe forms of dengue virus infection, dengue hemorrhagic fever and dengue shock syndrome
    Thi Phuong Lan Nguyen
    Department of Immunogenetics, Institute of Tropical Medicine NEKKEN, Nagasaki University, Japan
    PLoS Negl Trop Dis 2:e304. 2008
    ..Recently, the severe forms, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), have become the leading cause of death among children in Southern ..
  39. ncbi [Economic impact of dengue and dengue hemorrhagic fever in the State of Zulia, Venezuela, 1997-2003]
    Germán Añez
    Seccion de Virologia, Instituto de Investigaciones Clinicas Dr Americo Negrette, Facultad de Medicina, Universidad del Zulia, Maracaibo, Estado Zulia, Venezuela
    Rev Panam Salud Publica 19:314-20. 2006
    To determine the direct and indirect costs of medical care provided to cases of dengue and dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) between 1997 and 2003 in Zulia State, Venezuela.
  40. pmc Allergies and diabetes as risk factors for dengue hemorrhagic fever: results of a case control study
    Maria Aparecida A Figueiredo
    State University of Bahia, Salvador, Brazil
    PLoS Negl Trop Dis 4:e699. 2010
    The physiopathology of dengue hemorrhagic fever (DHF), a severe form of Dengue Fever, is poorly understood...
  41. ncbi High levels of plasma dengue viral load during defervescence in patients with dengue hemorrhagic fever: implications for pathogenesis
    Wei Kung Wang
    Institute of Microbiology, College of Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
    Virology 305:330-8. 2003
    Studies of the pathogenesis of dengue hemorrhagic fever (DHF), a potentially life-threatening disease, have revealed the importance of initial high levels of virus replication...
  42. ncbi Slower rates of clearance of viral load and virus-containing immune complexes in patients with dengue hemorrhagic fever
    Wei Kung Wang
    Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, 100, Taiwan
    Clin Infect Dis 43:1023-30. 2006
    ..an initial high level of dengue virus replication to the severe and potentially life-threatening diseases dengue hemorrhagic fever (DHF) and dengue shock syndrome, the involvement of dengue virus in the immunopathological processes ..
  43. ncbi Cytokine cascade in dengue hemorrhagic fever: implications for pathogenesis
    U C Chaturvedi
    Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait
    FEMS Immunol Med Microbiol 28:183-8. 2000
    Dengue virus produces a mild acute febrile illness, dengue fever (DF) and a severe illness, dengue hemorrhagic fever (DHF)...
  44. ncbi HLA-A and -B allele associations with secondary dengue virus infections correlate with disease severity and the infecting viral serotype in ethnic Thais
    H A F Stephens
    Institute of Urology and Nephrology, University College, London, UK
    Tissue Antigens 60:309-18. 2002
    ..Appropriate paradigms for immunogenetic studies of acute viral infections are dengue fever (DF) and dengue hemorrhagic fever (DHF)...
  45. pmc Patterns of host genome-wide gene transcript abundance in the peripheral blood of patients with acute dengue hemorrhagic fever
    Cameron P Simmons
    Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
    J Infect Dis 195:1097-107. 2007
    Responses by peripheral blood leukocytes may contribute to the pathogenesis of dengue hemorrhagic fever (DHF). We used DNA microarrays to reveal transcriptional patterns in the blood of 14 adults with DHF...
  46. ncbi Strong HLA class I--restricted T cell responses in dengue hemorrhagic fever: a double-edged sword?
    H Loke
    Nuffield Department of Medicine, John Radcliffe Hospital and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    J Infect Dis 184:1369-73. 2001
    ..In a large case-control study of Vietnamese patients with dengue hemorrhagic fever (DHF), variation at the HLA-A locus was significantly associated with susceptibility to DHF (P=...
  47. ncbi Effect of age on outcome of secondary dengue 2 infections
    Maria G Guzman
    Department of Virology, PAHO WHO Collaborating Center for Viral Diseases, Tropical Medicine Institute of Havana, Cuba
    Int J Infect Dis 6:118-24. 2002
    b>Dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) is a growing global health problem. It is not known how age affects the outcome of secondary dengue infections...
  48. ncbi Comparison of clinical features and hematologic abnormalities between dengue fever and dengue hemorrhagic fever among children in the Philippines
    Celia C Carlos
    Department of Pediatrics, and Research and Biotechnology Division, St Luke s Medical Center, Quezon City, The Philippines
    Am J Trop Med Hyg 73:435-40. 2005
    ..the differences of clinical features and hematologic abnormalities between dengue fever (DF) and dengue hemorrhagic fever (DHF), 359 pediatric patients admitted St...
  49. ncbi Natural history of plasma leakage in dengue hemorrhagic fever: a serial ultrasonographic study
    Anon Srikiatkhachorn
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Pediatr Infect Dis J 26:283-90; discussion 291-2. 2007
    Although plasma leakage is the major cause of mortality and morbidity in patients with dengue hemorrhagic fever (DHF), a detailed assessment of the natural course of this process is still lacking...
  50. ncbi Severe dengue: the need for new case definitions
    José G Rigau-Pérez
    Dengue Branch, Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, San Juan, PR, USA
    Lancet Infect Dis 6:297-302. 2006
    ..In addition, for an accurate estimation of dengue burden, locally appropriate definitions of severe dengue must be devised and standardised so they will be considered valid in the global research community...
  51. ncbi Dengue hemorrhagic Fever caused by sequential dengue 1-3 virus infections over a long time interval: Havana epidemic, 2001-2002
    Mayling Alvarez
    Department of Virology, Pan American Health Organization World Health Organization Collaborating Center for the Study of Dengue and its Vector, Pedro Kouri Tropical Medicine Institute, Havana, Cuba
    Am J Trop Med Hyg 75:1113-7. 2006
    A dengue epidemic caused by dengue virus 3 (DENV-3) occurred in Cuba in 2001-2002. It included cases of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS)...
  52. ncbi Failure of secondary infection with American genotype dengue 2 to cause dengue haemorrhagic fever
    D M Watts
    Naval Medical Research Center Detachment, AMEMB NAMRID, Unit 3800, Lima, Peru
    Lancet 354:1431-4. 1999
    ..Possibly American DEN-2 genotype strains lacked properties necessary to cause severe disease. We report on a major epidemic of DEN-2 in Peru in 1995, about 5 years after an epidemic of DEN-1 in the same population...
  53. pmc Recent shift in age pattern of dengue hemorrhagic fever, Brazil
    Maria Gloria Teixeira
    Emerg Infect Dis 14:1663. 2008
  54. ncbi Epidemiology of dengue and dengue hemorrhagic fever in a cohort of adults living in Bandung, West Java, Indonesia
    Kevin R Porter
    Viral Diseases Program, Naval Medical Research Unit No 2, Jakarta, Indonesia
    Am J Trop Med Hyg 72:60-6. 2005
    A prospective study of dengue fever (DF) and dengue hemorrhagic fever (DHF) was conducted in a cohort of adult volunteers from two textile factories located in West Java, Indonesia...
  55. ncbi The climatic factors influencing the occurrence of dengue hemorrhagic fever in Thailand
    Suwich Thammapalo
    Bureau of Vector borne Disease Control, Ministry of Public Health, Nonthaburi, Thailand
    Southeast Asian J Trop Med Public Health 36:191-6. 2005
    ..effects of climatic factors: rainfall, temperature and relative humidity, on the occurrence of dengue hemorrhagic fever (DHF) in Thailand after adjustment for cyclical pattern...
  56. ncbi Thrombocytopenia associated with dengue hemorrhagic fever responds to intravenous administration of anti-D (Rh(0)-D) immune globulin
    Reynaldo Angelo C de Castro
    De La Salle University Health Sciences Campus, Far Eastern University, Pediatric Hematology Philippine Children s Medical Center and Department of Pediatrics, Manila, Philippines
    Am J Trop Med Hyg 76:737-42. 2007
    Severe thrombocytopenia and increased vascular permeability are two major characteristics of dengue hemorrhagic fever (DHF)...
  57. ncbi Epidemic dengue and dengue hemorrhagic fever at the Texas-Mexico border: results of a household-based seroepidemiologic survey, December 2005
    Mary M Ramos
    Dengue Branch, Division of Vector Borne Infectious Disease, Centers for Disease Control and Prevention, San Juan, Puerto Rico
    Am J Trop Med Hyg 78:364-9. 2008
    A dengue-2 epidemic causing dengue hemorrhagic fever (DHF) occurred in the contiguous border cities of Matamoros, Tamaulipas (Mexico), and Brownsville, TX, in 2005...
  58. ncbi Assessment of World Health Organization definition of dengue hemorrhagic fever in North India
    Prashant Gupta
    1Department of Microbiology, Chhatrapati Shahuji Maharaj Medical University, Lucknow, UP, India
    J Infect Dev Ctries 4:150-5. 2010
    ..In this prospective study of dengue infection during an epidemic in India in 2004, we applied the WHO classification of dengue to assess its usefulness for our patients...
  59. ncbi Phenotypic and genotypic characterization of dengue virus isolates differentiates dengue fever and dengue hemorrhagic fever from dengue shock syndrome
    Anne Tuiskunen
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Arch Virol 156:2023-32. 2011
    ..cause 50-100 million cases of acute febrile disease every year, including 500,000 reported cases of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS)...
  60. pmc Dengue hemorrhagic fever-associated immunomediators induced via maturation of dengue virus nonstructural 4B protein in monocytes modulate endothelial cell adhesion molecules and human microvascular endothelial cells permeability
    James F Kelley
    Department of Tropical Medicine, Medical Microbiology and Pharmacology, Pacific Center for Emerging Infectious Diseases Research, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA
    Virology 422:326-37. 2012
    We previously demonstrated that dengue virus (DENV) nonstructural 4B protein (NS4B) induced dengue hemorrhagic fever (DHF)-associated immunomediators in THP-1 monocytes...
  61. ncbi Impaired fibrinolysis in the pathogenesis of dengue hemorrhagic fever
    Eric C M van Gorp
    Department of Internal Medicine, Slotervaart Hospital, Amsterdam, Netherlands
    J Med Virol 67:549-54. 2002
    The mechanisms contributing to bleeding complications in dengue hemorrhagic fever were studied by investigating the pattern of activation of the coagulation and fibrinolytic systems in 50 children with severe dengue hemorrhagic fever...
  62. ncbi Secreted complement regulatory protein clusterin interacts with dengue virus nonstructural protein 1
    Takeshi Kurosu
    Research Collaboration Center on Emerging and Re emerging Infections RCC ERI, Tiwanon Rd, Muang, Nonthaburi 11000, Thailand
    Biochem Biophys Res Commun 362:1051-6. 2007
    Vascular leakage and shock are the major causes of death in patients with dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS)...
  63. pmc Discovery proteomics and nonparametric modeling pipeline in the development of a candidate biomarker panel for dengue hemorrhagic fever
    Allan R Brasier
    Department of Internal Medicine, University of Texas Medical Branch UTMB, Galveston, Texas, USA
    Clin Transl Sci 5:8-20. 2012
    ..Secondary dengue viral infection can produce capillary leakage associated with increased mortality known as dengue hemorrhagic fever (DHF)...
  64. ncbi Early CD69 expression on peripheral blood lymphocytes from children with dengue hemorrhagic fever
    S Green
    Center for Infectious Disease, University of Massachusetts, Worcester, MA, USA
    J Infect Dis 180:1429-35. 1999
    Recent reports have demonstrated immune activation in dengue hemorrhagic fever (DHF) by cytokine and soluble receptor detection in blood...
  65. ncbi Fatal dengue hemorrhagic fever in adults during a dengue epidemic in Singapore
    Adrian Ong
    Department of Infectious Diseases, Tan Tock Seng Hospital, 11 Jln Tan Tock Seng, 308433 Singapore
    Int J Infect Dis 11:263-7. 2007
    ..Associated with the rise of dengue has been the increase in dengue-associated mortality. To better understand the predictors of mortality, we conducted a review of hospitalized adult dengue infections within our institution...
  66. ncbi Autoimmune pathogenesis in dengue virus infection
    Chiou Feng Lin
    Department of Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan
    Viral Immunol 19:127-32. 2006
    The pathogenic mechanisms of dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS) caused by dengue virus (DV) infection remain unresolved...
  67. pmc Dengue epidemic in southern Vietnam, 1998
    D Q Ha
    Pasteur Institute, Ho Chi Minh City, Vietnam
    Emerg Infect Dis 6:422-5. 2000
    A widespread epidemic of dengue hemorrhagic fever (DHF) occurred in southern Vietnam in 1998, with 438.98 cases/100,000 population and 342 deaths. The number of DHF cases and deaths per 100,000 population increased 152.4% and 151...
  68. ncbi Acute myocarditis in dengue hemorrhagic fever: a case report and review of cardiac complications in dengue-affected patients
    Ing Kit Lee
    Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Taiwan
    Int J Infect Dis 14:e919-22. 2010
    We report a case of dengue hemorrhagic fever (DHF) complicated by acute myocarditis and review the literature...
  69. ncbi Clinical characteristics of dengue and dengue hemorrhagic fever in a medical center of southern Taiwan during the 2002 epidemic
    Min Sheng Lee
    Division of Pediatric Infectious Disease, Department of Pediatrics, Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Microbiol Immunol Infect 39:121-9. 2006
    This study investigated the clinical manifestations and risk factors for dengue fever (DF) and dengue hemorrhagic fever (DHF) and disease severity during the 2002 outbreak in the Kaohsiung area.
  70. pmc Relationship between transmission intensity and incidence of dengue hemorrhagic fever in Thailand
    Suwich Thammapalo
    Bureau of Vector Borne Disease, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand
    PLoS Negl Trop Dis 2:e263. 2008
    Dengue is the most prevalent mosquito-borne virus, and potentially fatal dengue hemorrhagic fever (DHF) occurs mainly in secondary infections...
  71. ncbi Comparison of three fluid solutions for resuscitation in dengue shock syndrome
    Bridget A Wills
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    N Engl J Med 353:877-89. 2005
    ..Although volume replacement is recognized as the critical therapeutic intervention, World Health Organization management guidelines remain empirical rather than evidence-based...
  72. ncbi Isolation and characterization of two phenotypically distinct dengue type-2 virus isolates from the same dengue hemorrhagic Fever patient
    Hitomi Kinoshita
    Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852 8523, Japan
    Jpn J Infect Dis 62:343-50. 2009
    ..The dengue virus antigen was detected in peripheral CD19+ cells (B cells) in one dengue hemorrhagic fever patient...
  73. ncbi Pathologic study of a fatal case of dengue-3 virus infection in Rio de Janeiro, Brazil
    C A Basilio-de-Oliveira
    Gaffrée and Guinle Teaching Hospital, Federal University of Rio de Janeiro, Brazil
    Braz J Infect Dis 9:341-7. 2005
    b>Dengue hemorrhagic fever (DHF) is a severe febrile disease, characterized by abnormalities in hemostasis and increased vascular permeability, which in some cases results in hypovolemic shock syndrome and in dengue shock syndrome...
  74. pmc Both viremia and cytokine levels associate with the lack of severe disease in secondary dengue 1 infection among adult Chinese patients
    Yangbo Tang
    Department of Laboratory Medicine, Guangzhou 8th People s Hospital, Guangzhou Medical College, Guangzhou, China
    PLoS ONE 5:e15631. 2010
    Secondary dengue infections are frequently associated with increased risk for dengue hemorrhagic fever and dengue shock syndrome...
  75. pmc Severe dengue epidemics in Sri Lanka, 2003-2006
    Nalaka Kanakaratne
    Genetech Research Institute, Colombo, Sri Lanka
    Emerg Infect Dis 15:192-9. 2009
    Recent emergence of dengue hemorrhagic fever in the Indian subcontinent has been well documented in Sri Lanka. We compare recent (2003-2006) and past (1980-1997) dengue surveillance data for Sri Lanka...
  76. ncbi Clinical characteristics and risk factors for concurrent bacteremia in adults with dengue hemorrhagic fever
    Ing Kit Lee
    Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Taiwan, Republic of China
    Am J Trop Med Hyg 72:221-6. 2005
    ..better understand the clinical characteristics of concurrent bacteremia (dual infection) in patients with dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) and identify predictive risk factors for dual infection, 100 patients ..
  77. pmc Early T-cell responses to dengue virus epitopes in Vietnamese adults with secondary dengue virus infections
    Cameron P Simmons
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, District 5, Ho Chi Minh City, Vietnam
    J Virol 79:5665-75. 2005
    ..The results highlight the importance of NS3 and cross-reactive T cells during acute secondary infection but suggest that the overall breadth and magnitude of the T-cell response is not significantly related to clinical disease grade...
  78. ncbi Dengue
    Scott B Halstead
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20852, USA
    Curr Opin Infect Dis 15:471-6. 2002
    ..Because efforts to control dengue are flagging, this review focuses on the mechanisms underlying severe disease and on treatment options, good and bad...
  79. ncbi Vascular endothelium: the battlefield of dengue viruses
    Atanu Basu
    National Institute of Virology, Pune, India
    FEMS Immunol Med Microbiol 53:287-99. 2008
    ..The present review provides a broad overview of the effects of DV infection and the associated host responses contributing towards alterations in vascular endothelial cell physiology and damage that may be responsible for the DHF/DSS...
  80. ncbi Size and charge characteristics of the protein leak in dengue shock syndrome
    Bridget A Wills
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    J Infect Dis 190:810-8. 2004
    he mechanism underlying the transient vascular leak syndrome of dengue hemorrhagic fever (DHF) is unknown...
  81. pmc Reemergence of dengue virus type-3 (subtype-III) in India: implications for increased incidence of DHF & DSS
    Paban Kumar Dash
    Division of Virology, Defence R and D Establishment, Jhansi Road, Gwalior 474002, MP, India
    Virol J 3:55. 2006
    ..We have carried out a detailed investigation of the 2004 outbreak by Serosurveillance, RT-PCR, nested PCR, virus isolation and genotyping. We also report the molecular epidemiological investigation of these outbreaks...
  82. ncbi A clinical study of the patients with dengue hemorrhagic fever during the epidemic of 1996 at Lucknow, India
    R Agarwal
    Department of Microbiology, KG Medical College, Lucknow, India
    Southeast Asian J Trop Med Public Health 30:735-40. 1999
    This paper describes the clinical findings in 206 patients with dengue fever (DF) or with dengue hemorrhagic fever (DHF) during the epidemic of 1996 at Lucknow...
  83. ncbi Antibodies from dengue patient sera cross-react with endothelial cells and induce damage
    Chiou Feng Lin
    Department of Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan, Republic of China
    J Med Virol 69:82-90. 2003
    ..causes a wide range of diseases from the mild febrile illness dengue fever to the life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS)...
  84. ncbi The benign nature of acute dengue infection in hospitalized older adults in Singapore
    D C Lye
    Department of Infectious Disease, Tan Tock Seng Hospital, Singapore
    Int J Infect Dis 14:e410-3. 2010
    ..In Singapore, dengue primarily affects adults. This study aimed to determine if older dengue patients in Singapore have greater morbidity and mortality...
  85. ncbi Surveillance for an emerging disease: dengue hemorrhagic fever in Puerto Rico, 1988-1997. Puerto Rico Association of Epidemiologists
    J G Rigau-Perez
    Dengue Branch, Centers for Disease Control and Prevention, San Juan, Puerto Rico 00921 3200
    P R Health Sci J 18:337-45. 1999
    ..The dengue hemorrhagic fever (DHF) surveillance system in Puerto Rico collects patient data from three sources: dengue case ..
  86. pmc Emergence and global spread of a dengue serotype 3, subtype III virus
    William B Messer
    University of North Carolina, Chapel Hill, North Carolina, USA
    Emerg Infect Dis 9:800-9. 2003
    Over the past two decades, dengue virus serotype 3 (DENV-3) has caused unexpected epidemics of dengue hemorrhagic fever (DHF) in Sri Lanka, East Africa, and Latin America...
  87. pmc Antibodies play a greater role than immune cells in heterologous protection against secondary dengue virus infection in a mouse model
    Jennifer L Kyle
    Division of Infectious Diseases, School of Public Health, University of California, Berkeley, 1 Barker Hall 424, Berkeley, CA 94720 7354, USA
    Virology 380:296-303. 2008
    The four serotypes of dengue virus (DENV1-4) are causative agents of dengue fever and dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS)...
  88. pmc Virus-induced decline in soluble vascular endothelial growth receptor 2 is associated with plasma leakage in dengue hemorrhagic Fever
    Anon Srikiatkhachorn
    Center for Infectious Diseases and Vaccine Research, Rm S5 326, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 0002, USA
    J Virol 81:1592-600. 2007
    Some individuals infected with dengue virus develop dengue hemorrhagic fever (DHF), a viral hemorrhagic disease characterized by a transient period of localized plasma leakage...
  89. ncbi Dengue and dengue haemorrhagic fever: implications of host genetics
    Umeshc Chaturvedi
    Department of Microbiology, K G Medical University, Lucknow, India
    FEMS Immunol Med Microbiol 47:155-66. 2006
    ..The scanty positive data presented here indicate a need for detailed genetic studies in different ethnic groups in different countries during the acute phase of DF and DHF on a larger number of patients...
  90. ncbi Coagulation abnormalities in dengue hemorrhagic Fever: serial investigations in 167 Vietnamese children with Dengue shock syndrome
    Bridget A Wills
    Centre for Tropical Diseases and Wellcome Trust Clinical Research Unit, Cho Quan Hospital, Ho Chi Minh City, Vietnam
    Clin Infect Dis 35:277-85. 2002
    ..Rather than causing true disseminated intravascular coagulation, dengue infection may activate fibrinolysis primarily, degrading fibrinogen directly and prompting secondary activation of procoagulant homeostatic mechanisms...
  91. ncbi Transmission of epidemic dengue hemorrhagic fever in easternmost Indonesia
    Nono C Sukri
    United States Naval Medical Research Unit No 2, Jakarta, Indonesia
    Am J Trop Med Hyg 68:529-35. 2003
    In April 2001, a second suspected outbreak of dengue hemorrhagic fever in the easternmost region of Indonesia was investigated in Merauke, a town located in the southeastern corner of Papua, by the Indonesian Ministry of Health and the U...
  92. pmc Serotype-specific differences in the risk of dengue hemorrhagic fever: an analysis of data collected in Bangkok, Thailand from 1994 to 2006
    Jessica R Fried
    Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Negl Trop Dis 4:e617. 2010
    ..It is unclear whether dengue serotypes differ in their propensity to cause severe disease. We analyzed differences in serotype-specific disease severity in children presenting for medical attention in Bangkok, Thailand...
  93. ncbi Immunopathological mechanisms in dengue and dengue hemorrhagic fever
    Sharone Green
    University of Massachusetts Medical School, Center for Infectious Disease and Vaccine Research, Worcester, Massachusetts 01655, USA
    Curr Opin Infect Dis 19:429-36. 2006
    The continued emergence of dengue virus infection and its severe disease manifestation, dengue hemorrhagic fever, is a growing public health problem...
  94. ncbi T cell responses in dengue hemorrhagic fever: are cross-reactive T cells suboptimal?
    Juthathip Mongkolsapaya
    Department of Immunology, Division of Medicine, Hammersmith Hospital, Imperial College, Du Cane Road, London W12 0NN, United Kingdom
    J Immunol 176:3821-9. 2006
    ..Cross-reactive Dengue-specific T cells seem to show suboptimal degranulation but high cytokine production, which may contribute to the development of the vascular leak characteristic of Dengue hemorrhagic fever.
  95. ncbi Role of T cells, cytokines and antibody in dengue fever and dengue haemorrhagic fever
    Joshua Fink
    Novartis Institute for Tropical Diseases, 10 Biopolis Road, 05 01 Chromos, Singapore
    Rev Med Virol 16:263-75. 2006
    ..The need for effective measures against dengue and dengue-related illness is clear. We propose that drugs against dengue virus, or the symptoms of severe dengue disease, are a viable goal...
  96. pmc Age and clinical dengue illness
    Joseph R Egger
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    Emerg Infect Dis 13:924-5. 2007
    ..We use data from clinical patients to show that the relative risk of having classical disease after primary dengue virus infection increases with age. This relationship has implications for strategies aimed at controlling dengue fever...
  97. ncbi Dengue hemorrhagic fever: two infections and antibody dependent enhancement, a brief history and personal memoir
    Scott B Halstead
    Department of Molecular Microbiology and Immunology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Rev Cubana Med Trop 54:171-9. 2002
  98. pmc DC-SIGN (CD209) Promoter -336 A/G polymorphism is associated with dengue hemorrhagic fever and correlated to DC-SIGN expression and immune augmentation
    Lin Wang
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center CGMH KMC, Kaohsiung, Taiwan
    PLoS Negl Trop Dis 5:e934. 2011
    ..We reason that variations in the DC-SIGN gene might have a broad influence on viral replication and host immune responses...
  99. ncbi Blood zinc levels and clinical severity of dengue hemorrhagic fever in children
    - Widagdo
    Department of Child Health, Faculty of Medicine, Trisakti University, 140 Kiyai Tapa, Grogol, Jakarta 11440, Indonesia
    Southeast Asian J Trop Med Public Health 39:610-6. 2008
    ..04+1.30X, p<0.05 and a coefficient correlation of r: 0.47. Therefore, no association was found between zinc levels and clinical severity of DHF in children...
  100. ncbi Dengue and dengue hemorrhagic fever: management issues in an intensive care unit
    Sunit Singhi
    The Department of Pediatrics, Advanced Pediatrics Centre, Postrgraduate Institute of Medical Education and Research, Chandigarh, India
    J Pediatr (Rio J) 83:S22-35. 2007
    ..To describe the epidemiology, clinical features and treatment of dengue fever and dengue shock syndrome...
  101. pmc Cross-reactive T-cell responses to the nonstructural regions of dengue viruses among dengue fever and dengue hemorrhagic fever patients in Malaysia
    Ramapraba Appanna
    Department of Medical Microbiology, Faculty of Medicine, University Malaya, 50603, Kuala Lumpur, Malaysia
    Clin Vaccine Immunol 14:969-77. 2007
    ..enzyme-linked immunospot (ELISPOT) assay of samples from 13 selected patients with dengue fever (DF) and dengue hemorrhagic fever (DHF). NS3 and predominantly NS3(422-431) were found to be important T-cell targets...

Research Grants62

  1. Dengue Infected Endothelial Cells Enhance Immune Cell Activation
    Erich R Mackow; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dengue fever (DF), dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) are diseases caused by 4 serotypes of dengue virus (DV)...
  2. Development of a Recombinant Tetravalent Dengue Vaccine Based on a Subunit Envelo
    Lynda G Tussey; Fiscal Year: 2013
    ..to -4) because sequential infection by different dengue virus serotypes can lead to life-threatening dengue hemorrhagic fever or dengue shock syndrome...
  3. Mosquito Saliva in Dengue Virus Pathogenesis
    REBECCA R RICO-HESSE; Fiscal Year: 2013
    ..Dengue viruses cause an estimated 5 million new cases of DF and 250,000 cases of dengue hemorrhagic fever (DHF) per year in tropical and subtropical areas of the world, with >100 countries with endemic ..
  4. Fitness and Virulence of Dengue Virus in the Context of Changing Host Immunity
    Eva Harris; Fiscal Year: 2012
    ..DENV infection results in dengue fever, an acute febrile illness, or the more severe, life- threatening dengue hemorrhagic fever/dengue shock syndrome...
  5. Novel Tetravalent Vaccines for Dengue Virus
    ROBERT GERALD WHALEN; Fiscal Year: 2013
    ..Sequential infections by different serotypes can cause an enhanced disease known as dengue hemorrhagic fever. Ideally, dengue vaccines should protect against all serotypes simultaneously or within a short time ..
  6. Mechanisms of sylvatic dengue emergence
    Scott C Weaver; Fiscal Year: 2011
    ..DENV infects 100 million people per year in over 100 countries, causing classical dengue fever as well as dengue hemorrhagic fever and dengue shock syndrome, while CHIKV has caused recent epidemics involving over 2 million persons with ..
  7. A new synergy for flavivirus therapy: RNAi enhancement and viral mutagens
    KATHRYN ALYCE HANLEY; Fiscal Year: 2012
    ..For example the annual number of cases of dengue hemorrhagic fever cases worldwide has risen from nearly 0 in the 1950's to 500,000 today...
  8. Slit2N for the Treatment of Viral Hemorrhagic Fever
    ALAN L MUELLER; Fiscal Year: 2012
    ..and mortality has been studied in multiple forms of hemorrhagic fever and it has been well established in dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) which are characterized by fever and vascular leakage resulting in ..
  9. Validation of Src kinases as Anti-Dengue Viral Targets
    PRISCILLA LI NING YANG; Fiscal Year: 2012
    ..These small molecules can then be used to study how dengue virus interacts with its host and to develop therapies for the treatment of dengue virus infections. ..
  10. Altered peptide ligands and immunopathogenesis of dengue virus infection
    ALLISON ANNE IMRIE; Fiscal Year: 2010
    ..A small proportion of dengue fever cases progress to dengue hemorrhagic fever (DHF), or to the most severe form of the disease, dengue shock syndrome (DSS)...
  11. Inhibiting Cellular Autophagy to Thwart Dengue Virus Packaging and Replication
    Karla Kirkegaard; Fiscal Year: 2013
    ..infection severity ranges from the self-limiting Dengue fever to the more lethal forms of the disease, Dengue hemorrhagic fever and Dengue shock syndrome...
  12. Sustainable Control of Aedes aegypti and epidemic dengue
    Lars Eisen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Epidemic dengue fever and dengue hemorrhagic fever are major public health problems in the Americas...
  13. Determinants of protection and enhancement of dengue infection/disease in vivo
    Eva Harris; Fiscal Year: 2013
    ..DENV infection results in dengue fever, an acute febrile illness, or the more severe, life- threatening dengue hemorrhagic fever/dengue shock syndrome...
  14. Genetic approaches to discover host factors critical to dengue virus infection
    JAN EDUARD CARETTE; Fiscal Year: 2012
    ..an estimated 100 million cases of dengue fever, in which symptoms range from a mild fever to severe dengue hemorrhagic fever in approximately 250.000 cases...
  15. Metabolomics-based discovery of small molecule biomarkers for noninvasive dengue
    Barry J Beaty; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Epidemic dengue fever (DF) and dengue hemorrhagic fever (DHF/DSS) have emerged throughout the tropical world with devastating public health consequences...
  16. Therapy of Dengue with Modified Antibodies in Humanized Mice
    REBECCA R RICO-HESSE; Fiscal Year: 2013
    ..Dengue viruses cause an estimated 25 million new cases of DF and 250,000 cases of dengue hemorrhagic fever (DHF) per year in tropical and subtropical areas of the world, with >100 countries with endemic ..
  17. Tetravalent dengue vaccine based on complex adenovirus vectors
    Kanakatte Raviprakash; Fiscal Year: 2010
    ..Four distinct serotypes of dengue viruses cause widespread dengue fever (DF) and the more serious dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS)...
  18. Innate immune mechanisms in dengue infection
    Kovit Pattanapanyasat; Fiscal Year: 2013
    ..Our lab has been studying the acute response to dengue virus in patients with dengue fever (DF) and dengue hemorrhagic fever (DHF) in attempts to delineate biological markers that can distinguish DF from DHF in an endemic ..
  19. A Clinical Study of Protective and Pathogenic Immunity to Dengue during Infancy
    Daniel H Libraty; Fiscal Year: 2013
    ..A fine line exists between protective immunity and pathogenic immune responses that lead to severe dengue hemorrhagic fever (DHF)...
  20. Second Generation Dengue Vaccine
    DAN THOMAS STINCHCOMB; Fiscal Year: 2010
    ..5 billion people worldwide. The dengue viruses cause dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS), and are endemic throughout the world's subtropical and ..
  21. Improving Robustness of a Tactical Model of Aedes/Dengue Dynamics
    Fred Gould; Fiscal Year: 2013
    ..million cases of dengue fever (break-bone fever) and about 500,000 cases of the more life-threatening dengue hemorrhagic fever occur annually...
  22. Recombination-mediated cassette exchange in Aedes aegypti mosquitoes
    Zach N Adelman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Vector-borne diseases such as malaria and dengue hemorrhagic fever remain large public health burdens, and novel interventions are still needed...
  23. Antiviral therapeutics for flavivirus infections
    CHELSEA BYRD OLSEN; Fiscal Year: 2013
    ..worldwide with dengue every year, including 500,000 cases of the more severe form of the disease, dengue hemorrhagic fever (DHF) and there are no approved vaccines or antiviral drugs available...
  24. Mast Cells in Dengue Pathology and Prevention
    Soman N Abraham; Fiscal Year: 2013
    ..Dengue virus (DENV) is the cause of the acute febrile and debilitating diseases dengue fever and dengue hemorrhagic fever (DHF)...
  25. Mucosal Vaccination Against Dengue Virus Infection
    SUJAN contact SHRESTA; Fiscal Year: 2010
    Dengue virus (DENV) causes dengue fever (DF) and dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), the most prevalent mosquito-borne viral illnesses in humans worldwide...
  26. Nanoscale Optofluidic Pathogen Detection
    David Erickson; Fiscal Year: 2009
    ..It causes an estimated 50 million illnesses annually, including 250,000-500,000 cases of Dengue Hemorrhagic Fever with 5-10% of mortality...
  27. Examination of the Molecular Mechanisms of Mosquito Odorant Receptors
    Gregory M Pask; Fiscal Year: 2012
    ..has been targeted as a means to decrease the spread of mosquito borne diseases, including malaria, dengue hemorrhagic fever, and West Nile encephalitis...
  28. Antibody-Based Protection Against Dengue Virus
    Michael G Rossmann; Fiscal Year: 2013
    ..the four serotypes of DENV cause an estimated 100 million new cases of dengue fever and 250,000 cases of dengue hemorrhagic fever (DHF) per year...
  29. Dengue Epitope Vaccine,Tetravalent & MHCII-Targeted
    J Thomas August; Fiscal Year: 2007
    ..both for their possible role in prevention of infection and proposed negative role in the etiology of dengue hemorrhagic fever. A human ex vivo T-cell activation assay will be used to analyze the biological correlates of the ..
  30. Training in Dengue Prevention and Control
    William C Black; Fiscal Year: 2013
    ..virus (DENV1-4) mosquito vector Aedes aegypti and subsequent prevention of epidemic dengue fever (DF) and Dengue Hemorrhagic Fever (DHF). Both diseases have emerged as major public health problems in the Americas...
  31. The Effects of Antibodies on Vascular Permeability in Dengue Virus Infection
    Lindsey E Bazzone; Fiscal Year: 2013
    ..specifically their ability to induce vascular leak in vitro and in vivo, and will provide a clearer understanding of the role of DENV Abs in the induction of Dengue Hemorrhagic Fever/Dengue Shock Syndrome (DHF/DSS).
  32. A VEE Replicon-Based Vaccine for Dengue Virus
    Laura White; Fiscal Year: 2006
    ..emerging pathogens, infects humans causing a spectrum of clinical manifestations including dengue fever, dengue hemorrhagic fever and dengue shock syndrome...
  33. Automated Molecular Diagnostics for Rapid Detection of Dengue Viremia Using Whole
    Shuqi Chen; Fiscal Year: 2012
    ..based on IQuum's lab-in-a-tube (Liat") platform for the diagnosis of patients with dengue fever or dengue hemorrhagic fever from whole blood samples...
  34. STRUCTURE BASED ANALYSIS OF DENGUE VIRUS SERINE PROTEASE
    Krishna Murthy; Fiscal Year: 2004
    ..Of these, more than 250,000 cases involve life-threatening dengue hemorrhagic fever/dengue shock syndrome with no effective chemotherapy or vaccine currently available...
  35. FUNCTIONAL ANALYSIS OF DENGUE VIRUS ANTIGENS NS3 AND NS5
    Radhakrishnan Padmanabhan; Fiscal Year: 2003
    ..Of these, more than 250,000 cases involve life threatening dengue hemorrhagic fever / dengue shock syndrome...
  36. Analysis of clinical laboratory variables for early dengue illness classification
    James Potts; Fiscal Year: 2009
    ..dengue can manifest a more severe illness with bleeding tendency, thrombocytopenia, and plasma leakage (dengue hemorrhagic fever, DHF)...
  37. CONTROL OF URBAN CONTAINER BREEDING ARBROVIRUS VECTORS
    Dawn Wesson; Fiscal Year: 2007
    Emerging viral diseases, such as dengue hemorrhagic fever and West Nile viral encephalitis, pose a significant threat to public health...
  38. Anti-Flavivirus Immunotherapeutics
    EILEEN NAKANO; Fiscal Year: 2001
    ..There are 100 million cases of dengue infection each year with 250,000 cases of the life-threatening Dengue Hemorrhagic Fever/Dengue Shock Syndrome (DHS/DSS). Treatment options are limited to symptoms management...
  39. Latin America Workshop On Denge
    Jorge Osorio; Fiscal Year: 2009
    ..DENV causes classic Dengue ("break-bone") fever (DF), and more severe and sometimes fatal dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS)...
  40. Novel small molecule inhibitors of dengue replication
    Dennis Hruby; Fiscal Year: 2009
    ..worldwide with dengue every year, including 500,000 cases of the more severe form of the disease, dengue hemorrhagic fever (DHF) and there are no approved vaccines or antiviral drugs available...
  41. PULSED ELECTRIC FIELD DELIVERED DENGUE VACCINE
    Alan King; Fiscal Year: 2000
    ..During this time, the Americas have seen the emergence of the most severe form of dengue, dengue hemorrhagic fever. In endemic areas, such as Southeast Asia, it is a disease of children and is a common cause of morbidity ..
  42. MICROCHIP-BASED FIELD ASSAY TO DETECT DENGUE VIRUS
    RICHARD MONTAGNA; Fiscal Year: 2000
    Dengue virus is the etiological agent responsible for Dengue Fever (DF), Dengue Hemorrhagic Fever (DHF), and Dengue Shock Syndrome (DSS)...
  43. INTERFERENCE TO DENGUE VIRUS REPLICATION IN MOSQUITOES
    Carol Blair; Fiscal Year: 2006
    ..About 50-100 million cases of dengue fever (DF) and >100,000 cases of life-threatening dengue hemorrhagic fever (DHF) occur annually worldwide...
  44. Discovery of Broad Spectrum Dengue Virus Proteinase Inhibitors
    Alan Johnson; Fiscal Year: 2009
    ..50 to 100 million infections occur annually resulting in an estimated 500,000 cases of life threatening dengue hemorrhagic fever or dengue shock syndrome...
  45. Structure Based Design of Dengue Virus Fusion Inhibitors
    SHERRI MILLIS; Fiscal Year: 2007
    ..50 to 100 million infections occur annually resulting in an estimated 500,000 cases of life threatening dengue hemorrhagic fever or dengue shock syndrome...
  46. IMMUNE RESPONSES TO DENGUE VIRUSES
    Francis Ennis; Fiscal Year: 2001
    ..Epidemiological studies have shown that the severe complications of infection, dengue hemorrhagic fever (DHF), are much more commonly observed during secondary infections with a different serotype of dengue ..
  47. A NOVEL ADENOVIRUS-BASED TETRAVALENT DENGUE VACCINE
    STEPHEN DEITZ; Fiscal Year: 2002
    ..We have chosen to focus our attention on one potential bioweapon: dengue virus. Dengue fever and dengue hemorrhagic fever are incapacitating, potentially lethal diseases that are caused by dengue virus infection...
  48. BLOCKING DENGUE TRANSMISSION BY TRANSGENIC AEDES AEGYPTI
    KENNETH OLSON; Fiscal Year: 2005
    DESCRIPTION: Dengue (DEN) and dengue hemorrhagic fever (DHF) have emerged as the most important mosquito-borne viral diseases affecting humans...
  49. Dengue Reporter Virus Neutralization Assay for Clinical Studies
    Eva Harris; Fiscal Year: 2009
    ..resulting in an estimated 50 million cases of dengue fever and over 450,000 cases of life-threatening dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) each year...
  50. Preclinical Development of a Recombinant Dengue Vaccine
    Carolyn Weeks Levy; Fiscal Year: 2005
    ..Dengue and dengue hemorrhagic fever are caused by one of four closely related virus serotypes...
  51. MICROCHIP-BASED FIELD ASSAY TO DETECT DENGUE VIRUS
    RICHARD MONTAGNA; Fiscal Year: 2003
    Up to 100 million Dengue virus infections occur annually world wide. Associated pathologies (Dengue Hemorrhagic Fever, Dengue Shock Syndrome) result in >20,000 deaths annually, primarily in children...
  52. Study of murine interferon responses to dengue virus
    Sujan Shresta; Fiscal Year: 2006
    ..by applicant): Dengue virus (DEN), a NIAID bio-defense category A pathogen, causes dengue fever (DF) and dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), the most prevalent arthropod-borne viral illnesses in humans worldwide...
  53. A Study of Protective Immunity Against Dengue in Infants
    DANIEL LIBRATY; Fiscal Year: 2009
    ..a high priority emerging viral disease by the WHO, as over 1 billion people in the world are at risk for dengue hemorrhagic fever (DHF)...
  54. Evaluation Studies of a Dengue-2 DNA Vaccine in Monkeys
    IDALI MARTINEZ MARTINEZ; Fiscal Year: 2004
    Dengue fever and dengue hemorrhagic fever result from the infection with any of the four serotypes of dengue (DEN) viruses. These diseases have become a global public health problem, affecting 100 million people anually...
  55. MOLECULAR DETERMINANTS OF DENGUE EPIDEMIC POTENTIAL
    Barry Beaty; Fiscal Year: 2004
    This project addresses emerging problems with Dengue (DEN) in Mexico. DEN and dengue hemorrhagic fever (DHF) have emerged as major public health problems...
  56. CONTROL OF MOSQUITO BORNE PARASITES APOPTOSIS
    JAMES NISHIURA; Fiscal Year: 2000
    ..Some of these diseases include malaria, dengue fever, dengue hemorrhagic fever, yellow fever and forms of viral encephalitis...
  57. MOSQUITO OOCYTES - MECHANISM OF PROTEIN ACCUMULATION
    Alexander Raikhel; Fiscal Year: 2001
    The recent resurgence of vector-borne diseases, most notably malaria, dengue hemorrhagic fever, amongst other devastating infections, driven by resistance to conventional containment and treatment tactics, requires the unceasing search ..
  58. Cell Biology of Mild and Severe dengue 3 strains
    Cassandra Lambeth; Fiscal Year: 2006
    People living in Sri Lanka have started to experience large epidemics of dengue hemorrhagic fever (DHF) after 1989...
  59. Cell-free Biosensor for the Detection of Pathogens
    BENJAMIN DORANZ; Fiscal Year: 2005
    ..is important because sequential exposure to different serotypes increases the likelihood of developing dengue hemorrhagic fever. For such pathogens, characterizing not only the magnitude, but also the breadth, persistence, and ..
  60. The role of interferon-stimulated genes in antiviral immunity
    John W Schoggins; Fiscal Year: 2010
    ..is a global health concern that infects millions of people and causes dengue fever and the severe dengue hemorrhagic fever;FluA results in the death of more than 30,000 people each year in the US alone...
  61. Risk Factors for Dengue Hemorrhagic Fever in Sri Lanka
    Aravinda de Silva; Fiscal Year: 2008
    ..Despite the fact that dengue hemorrhagic fever (DHF) has emerged to be a major problem in the Indian subcontinent, the disease and viruses circulating ..
  62. Mechanisms for Hormone-Dependent NF-kB Activation
    Allan Brasier; Fiscal Year: 2007
    ..These studies will identify new therapeutic targets that can disrupt the vicious cycle of inflammation and atherosclerosis. ..