dengue hemorrhagic fever

Summary

Summary: A distinct and virulent form of DENGUE characterized by thrombocytopenia and hemoconcentration (grades I and II) and distinguished by a positive tourniquet test. When accompanied by circulatory failure and shock (grades III and IV), it is called dengue shock syndrome. (From Dorland, 28th ed)

Top Publications

  1. ncbi Humoral immune response of dengue hemorrhagic fever cases in children from Tegucigalpa, Honduras
    Ivette Lorenzana De Rivera
    Department of Microbiology, National Autonomous University of Honduras, Tegucigalpa, Honduras
    Am J Trop Med Hyg 79:262-6. 2008
  2. ncbi Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century
    Duane J Gubler
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Dept of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA
    Trends Microbiol 10:100-3. 2002
  3. ncbi Serotype-specific dengue virus circulation and dengue disease in Bangkok, Thailand from 1973 to 1999
    Ananda Nisalak
    Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Am J Trop Med Hyg 68:191-202. 2003
  4. ncbi Dengue and dengue hemorrhagic fever
    D J Gubler
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
    Clin Microbiol Rev 11:480-96. 1998
  5. ncbi Serotype-specific differences in the risk of dengue hemorrhagic fever: an analysis of data collected in Bangkok, Thailand from 1994 to 2006
    Jessica R Fried
    Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Negl Trop Dis 4:e617. 2010
  6. ncbi Effect of age on outcome of secondary dengue 2 infections
    Maria G Guzman
    Department of Virology, PAHO WHO Collaborating Center for Viral Diseases, Tropical Medicine Institute of Havana, Cuba
    Int J Infect Dis 6:118-24. 2002
  7. ncbi Classifying dengue: a review of the difficulties in using the WHO case classification for dengue haemorrhagic fever
    Shibani Bandyopadhyay
    Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Trop Med Int Health 11:1238-55. 2006
  8. ncbi Cytokine cascade in dengue hemorrhagic fever: implications for pathogenesis
    U C Chaturvedi
    Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait
    FEMS Immunol Med Microbiol 28:183-8. 2000
  9. ncbi Clinical and laboratory characteristics and risk factors for fatality in elderly patients with dengue hemorrhagic fever
    Ing Kit Lee
    Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien, Taiwan
    Am J Trop Med Hyg 79:149-53. 2008
  10. ncbi Immunopathological mechanisms in dengue and dengue hemorrhagic fever
    Sharone Green
    University of Massachusetts Medical School, Center for Infectious Disease and Vaccine Research, Worcester, Massachusetts 01655, USA
    Curr Opin Infect Dis 19:429-36. 2006

Research Grants

  1. Inhibition of the Membrane Fusion Proteins of Flaviviruses and Alphaviruses
    Margaret Kielian; Fiscal Year: 2007
  2. Mechanisms of sylvatic dengue emergence
    Scott C Weaver; Fiscal Year: 2010
  3. Mechanisms of sylvatic dengue emergence
    Scott Weaver; Fiscal Year: 2009
  4. Dengue Epitope Vaccine,Tetravalent & MHCII-Targeted
    J Thomas August; Fiscal Year: 2007
  5. FUNCTIONAL ANALYSIS OF DENGUE VIRUS ANTIGENS NS3 AND NS5
    Radhakrishnan Padmanabhan; Fiscal Year: 1993
  6. A VEE Replicon-Based Vaccine for Dengue Virus
    Laura White; Fiscal Year: 2006
  7. FUNCTIONAL ANALYSIS OF DENGUE VIRUS ANTIGENS NS3 AND NS5
    Radhakrishnan Padmanabhan; Fiscal Year: 2003
  8. Fitness and Virulence of Dengue Virus in the Context of Changing Host Immunity
    Eva Harris; Fiscal Year: 2010
  9. STRUCTURE BASED ANALYSIS OF DENGUE VIRUS SERINE PROTEASE
    Krishna Murthy; Fiscal Year: 2004
  10. Flavivirus Infections: Pathogenesis and Prevention
    Francis Ennis; Fiscal Year: 2007

Detail Information

Publications234 found, 100 shown here

  1. ncbi Humoral immune response of dengue hemorrhagic fever cases in children from Tegucigalpa, Honduras
    Ivette Lorenzana De Rivera
    Department of Microbiology, National Autonomous University of Honduras, Tegucigalpa, Honduras
    Am J Trop Med Hyg 79:262-6. 2008
    The humoral immune response in Honduran dengue hemorrhagic fever (DHF) hospitalized pediatric cases from the epidemics of 2004 and 2005 was studied in sera collected from 5 to 7 days of fever onset...
  2. ncbi Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century
    Duane J Gubler
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Dept of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA
    Trends Microbiol 10:100-3. 2002
    Dengue fever/dengue hemorrhagic fever is now one of the most important public health problems in tropical developing countries and also has major economic and societal consequences.
  3. ncbi Serotype-specific dengue virus circulation and dengue disease in Bangkok, Thailand from 1973 to 1999
    Ananda Nisalak
    Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Am J Trop Med Hyg 68:191-202. 2003
    ..DEN-3 was the most frequent serotype in primary dengue (49% of all isolates), DEN-2 in secondary and in dengue hemorrhagic fever (37% and 35%, respectively)...
  4. ncbi Dengue and dengue hemorrhagic fever
    D J Gubler
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
    Clin Microbiol Rev 11:480-96. 1998
    ..the development of hyperendemicity (the cocirculation of multiple serotypes), and the emergence of dengue hemorrhagic fever in new geographic regions...
  5. ncbi Serotype-specific differences in the risk of dengue hemorrhagic fever: an analysis of data collected in Bangkok, Thailand from 1994 to 2006
    Jessica R Fried
    Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Negl Trop Dis 4:e617. 2010
    ..It is unclear whether dengue serotypes differ in their propensity to cause severe disease. We analyzed differences in serotype-specific disease severity in children presenting for medical attention in Bangkok, Thailand...
  6. ncbi Effect of age on outcome of secondary dengue 2 infections
    Maria G Guzman
    Department of Virology, PAHO WHO Collaborating Center for Viral Diseases, Tropical Medicine Institute of Havana, Cuba
    Int J Infect Dis 6:118-24. 2002
    b>Dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) is a growing global health problem. It is not known how age affects the outcome of secondary dengue infections...
  7. ncbi Classifying dengue: a review of the difficulties in using the WHO case classification for dengue haemorrhagic fever
    Shibani Bandyopadhyay
    Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Trop Med Int Health 11:1238-55. 2006
    ....
  8. ncbi Cytokine cascade in dengue hemorrhagic fever: implications for pathogenesis
    U C Chaturvedi
    Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait
    FEMS Immunol Med Microbiol 28:183-8. 2000
    Dengue virus produces a mild acute febrile illness, dengue fever (DF) and a severe illness, dengue hemorrhagic fever (DHF)...
  9. ncbi Clinical and laboratory characteristics and risk factors for fatality in elderly patients with dengue hemorrhagic fever
    Ing Kit Lee
    Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien, Taiwan
    Am J Trop Med Hyg 79:149-53. 2008
    ..and laboratory characteristics and to identify risk factor(s) for fatality in elderly patients with dengue hemorrhagic fever (DHF), 66 elderly (age > or = 65 years) and 241 non-elderly adults (age, 19-64 years) with DHF were ..
  10. ncbi Immunopathological mechanisms in dengue and dengue hemorrhagic fever
    Sharone Green
    University of Massachusetts Medical School, Center for Infectious Disease and Vaccine Research, Worcester, Massachusetts 01655, USA
    Curr Opin Infect Dis 19:429-36. 2006
    PURPOSE OF REVIEW: The continued emergence of dengue virus infection and its severe disease manifestation, dengue hemorrhagic fever, is a growing public health problem...
  11. ncbi [Economic impact of dengue and dengue hemorrhagic fever in the State of Zulia, Venezuela, 1997-2003]
    Germán Añez
    Seccion de Virologia, Instituto de Investigaciones Clinicas Dr Americo Negrette, Facultad de Medicina, Universidad del Zulia, Maracaibo, Estado Zulia, Venezuela
    Rev Panam Salud Publica 19:314-20. 2006
    To determine the direct and indirect costs of medical care provided to cases of dengue and dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) between 1997 and 2003 in Zulia State, Venezuela.
  12. ncbi Murine model for dengue virus-induced lethal disease with increased vascular permeability
    Sujan Shresta
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    J Virol 80:10208-17. 2006
    Lack of an appropriate animal model for dengue virus (DEN), which causes dengue fever and dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), has impeded characterization of the mechanisms underlying the disease pathogenesis...
  13. ncbi Protective and enhancing HLA alleles, HLA-DRB1*0901 and HLA-A*24, for severe forms of dengue virus infection, dengue hemorrhagic fever and dengue shock syndrome
    Thi Phuong Lan Nguyen
    Department of Immunogenetics, Institute of Tropical Medicine NEKKEN, Nagasaki University, Japan
    PLoS Negl Trop Dis 2:e304. 2008
    ..Recently, the severe forms, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), have become the leading cause of death among children in Southern ..
  14. ncbi Relationship between transmission intensity and incidence of dengue hemorrhagic fever in Thailand
    Suwich Thammapalo
    Bureau of Vector Borne Disease, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand
    PLoS Negl Trop Dis 2:e263. 2008
    Dengue is the most prevalent mosquito-borne virus, and potentially fatal dengue hemorrhagic fever (DHF) occurs mainly in secondary infections...
  15. ncbi High levels of plasma dengue viral load during defervescence in patients with dengue hemorrhagic fever: implications for pathogenesis
    Wei Kung Wang
    Institute of Microbiology, College of Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
    Virology 305:330-8. 2003
    Studies of the pathogenesis of dengue hemorrhagic fever (DHF), a potentially life-threatening disease, have revealed the importance of initial high levels of virus replication...
  16. ncbi Epidemiology of dengue and dengue hemorrhagic fever in a cohort of adults living in Bandung, West Java, Indonesia
    Kevin R Porter
    Viral Diseases Program, Naval Medical Research Unit No 2, Jakarta, Indonesia
    Am J Trop Med Hyg 72:60-6. 2005
    A prospective study of dengue fever (DF) and dengue hemorrhagic fever (DHF) was conducted in a cohort of adult volunteers from two textile factories located in West Java, Indonesia...
  17. ncbi Age and clinical dengue illness
    Joseph R Egger
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    Emerg Infect Dis 13:924-5. 2007
    ..We use data from clinical patients to show that the relative risk of having classical disease after primary dengue virus infection increases with age. This relationship has implications for strategies aimed at controlling dengue fever...
  18. ncbi Comparison of three fluid solutions for resuscitation in dengue shock syndrome
    Bridget A Wills
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    N Engl J Med 353:877-89. 2005
    ..Although volume replacement is recognized as the critical therapeutic intervention, World Health Organization management guidelines remain empirical rather than evidence-based...
  19. ncbi Dengue hemorrhagic fever epidemiology in Thailand: description and forecasting of epidemics
    Philippe Barbazan
    Institut de Recherche pour le Developpement, IRD, 213 rue La Fayette, 75010 Paris, France
    Microbes Infect 4:699-705. 2002
    Despite the use of a variety of control strategies, dengue hemorrhagic fever (DHF) control is a major and permanent challenge for public health services in Thailand and in Southeast Asia...
  20. ncbi Dengue hemorrhagic fever outbreak in children in Port Sudan
    Amal Malik
    Department of Pediatric, Red Sea University, Port Sudan, Sudan
    J Infect Public Health 4:1-6. 2011
    Dengue fever (DF)/dengue hemorrhagic fever (DHF) has emerged as a global public health problem with countries in Asia and the Pacific sharing more than 70% of the disease burden...
  21. ncbi Severe dengue: the need for new case definitions
    José G Rigau-Pérez
    Dengue Branch, Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, San Juan, PR, USA
    Lancet Infect Dis 6:297-302. 2006
    ..In addition, for an accurate estimation of dengue burden, locally appropriate definitions of severe dengue must be devised and standardised so they will be considered valid in the global research community...
  22. ncbi Risk factors of dengue shock syndrome in children
    Taweewong Tantracheewathorn
    Department of Pediatrics, Bangkok Metropolitan Administration Medical College and Vajira Hospital, Dusit, Bangkok 10300, Thailand
    J Med Assoc Thai 90:272-7. 2007
    ..The morbidity and mortality from DSS can be decreased by early diagnosis of shock and adequate replacement of plasma loss. Therefore, determination of risk factors of DSS is crucial for early detection and proper management of shock...
  23. ncbi Understanding the contribution of cellular immunity to dengue disease pathogenesis
    Anuja Mathew
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Immunol Rev 225:300-13. 2008
    ..The strong association of severe dengue illness, dengue hemorrhagic fever (DHF), with heterologous secondary infection and high cytokine levels has led to a prevailing view that ..
  24. ncbi Prospective study of the duration and magnitude of viraemia in children hospitalised during the 1996-1997 dengue-2 outbreak in French Polynesia
    B Murgue
    Unité de Recherche en Virologie, Institut Territorial de Recherches Medicales Louis Malarde, Papeete, Tahiti, French Polynesia
    J Med Virol 60:432-8. 2000
    ..7-5.6 Log(10) TCID(50)/ml. A significant difference was not observed in the magnitude and duration of viraemia in patients with primary versus secondary infections. The severity of the illness, however, was correlated with both criteria...
  25. ncbi Risk factors and clinical features associated with severe dengue infection in adults and children during the 2001 epidemic in Chonburi, Thailand
    Ole Wichmann
    Institute of Tropical Medicine, Humboldt University, Berlin, Germany
    Trop Med Int Health 9:1022-9. 2004
    ..In recent years, there has been a progressive shift in age-distribution towards older children and adults. We investigated an outbreak in 2001 in both children and adults, in an endemic area of Thailand...
  26. ncbi Combination of CTLA-4 and TGFbeta1 gene polymorphisms associated with dengue hemorrhagic fever and virus load in a dengue-2 outbreak
    Rong Fu Chen
    Department of Medical Research, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University, Kaohsiung, Taiwan
    Clin Immunol 131:404-9. 2009
    The pathogenesis of dengue hemorrhagic fever (DHF) has been considered to be massive immune activation of T cells...
  27. ncbi Dengue hemorrhagic fever with special emphasis on immunopathogenesis
    Ichiro Kurane
    Department of Virology 1, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Comp Immunol Microbiol Infect Dis 30:329-40. 2007
    ..Dengue virus infection can be asymptomatic or causes two forms of illness, dengue fever (DF) and dengue hemorrhagic fever (DHF), which is the severe form of dengue illness and often fatal...
  28. ncbi Virus-induced decline in soluble vascular endothelial growth receptor 2 is associated with plasma leakage in dengue hemorrhagic Fever
    Anon Srikiatkhachorn
    Center for Infectious Diseases and Vaccine Research, Rm S5 326, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 0002, USA
    J Virol 81:1592-600. 2007
    Some individuals infected with dengue virus develop dengue hemorrhagic fever (DHF), a viral hemorrhagic disease characterized by a transient period of localized plasma leakage...
  29. ncbi Dengue: an escalating problem
    Robert V Gibbons
    Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20910-7500, USA
    BMJ 324:1563-6. 2002
  30. ncbi Autoimmune pathogenesis in dengue virus infection
    Chiou Feng Lin
    Department of Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan
    Viral Immunol 19:127-32. 2006
    The pathogenic mechanisms of dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS) caused by dengue virus (DV) infection remain unresolved...
  31. ncbi Fatal dengue hemorrhagic fever in adults during a dengue epidemic in Singapore
    Adrian Ong
    Department of Infectious Diseases, Tan Tock Seng Hospital, 11 Jln Tan Tock Seng, 308433 Singapore
    Int J Infect Dis 11:263-7. 2007
    ..Associated with the rise of dengue has been the increase in dengue-associated mortality. To better understand the predictors of mortality, we conducted a review of hospitalized adult dengue infections within our institution...
  32. ncbi Altered T helper 1 reaction but not increase of virus load in patients with dengue hemorrhagic fever
    Rong-Fu Chen
    Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan
    FEMS Immunol Med Microbiol 44:43-50. 2005
    To investigate whether dengue-2 patients with and without dengue hemorrhagic fever had different virus load, immune mediators, or T helper (Th) reaction, we simultaneously measured virus load, immune mediators and the Th1/Th2 ..
  33. ncbi Both virus and tumor necrosis factor alpha are critical for endothelium damage in a mouse model of dengue virus-induced hemorrhage
    Hsuen Chin Chen
    Graduate Institute of Immunology, National Taiwan University College of Medicine, No 1 Jen Ai Road, Section 1, Taipei 10051, Taiwan, Republic of China
    J Virol 81:5518-26. 2007
    ..This finding highlights the contribution of the innate immune response to dengue hemorrhage...
  34. ncbi Differing influences of virus burden and immune activation on disease severity in secondary dengue-3 virus infections
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Infect Dis 185:1213-21. 2002
    b>Dengue hemorrhagic fever (DHF), the most severe form of illness following infection with a dengue virus, is characterized by plasma leakage, thrombocytopenia, and hepatic inflammation...
  35. ncbi The economic impact of dengue hemorrhagic fever on family level in Southern Vietnam
    Mette Lønstrup Harving
    University of Copenhagen and Children s Hospital No 1, Ho Chi Minh City, Vietnam
    Dan Med Bull 54:170-2. 2007
    ..This study aims to measure the economic consequences of dengue hemorrhagic fever in Southern Vietnam on family level...
  36. ncbi Anti-dengue virus nonstructural protein 1 antibodies recognize protein disulfide isomerase on platelets and inhibit platelet aggregation
    Hsien Jen Cheng
    Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan, Taiwan
    Mol Immunol 47:398-406. 2009
    ..Furthermore, the cross-reactivity of dengue hemorrhagic fever patient sera with platelets was reduced when patient sera were preabsorbed with PDI or P311-330...
  37. ncbi Dengue virus serotype 2 from a sylvatic lineage isolated from a patient with dengue hemorrhagic fever
    Jane Cardosa
    Institute of Health and Community Medicine, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia
    PLoS Negl Trop Dis 3:e423. 2009
    ..A 20-year-old male developed dengue hemorrhagic fever (DHF) with thrombocytopenia (12,000/ul) and a raised hematocrit (29...
  38. ncbi Pathologic study of a fatal case of dengue-3 virus infection in Rio de Janeiro, Brazil
    C A Basilio-de-Oliveira
    Gaffrée and Guinle Teaching Hospital, Federal University of Rio de Janeiro, Brazil
    Braz J Infect Dis 9:341-7. 2005
    b>Dengue hemorrhagic fever (DHF) is a severe febrile disease, characterized by abnormalities in hemostasis and increased vascular permeability, which in some cases results in hypovolemic shock syndrome and in dengue shock syndrome...
  39. ncbi Patterns of host genome-wide gene transcript abundance in the peripheral blood of patients with acute dengue hemorrhagic fever
    Cameron P Simmons
    Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
    J Infect Dis 195:1097-107. 2007
    Responses by peripheral blood leukocytes may contribute to the pathogenesis of dengue hemorrhagic fever (DHF). We used DNA microarrays to reveal transcriptional patterns in the blood of 14 adults with DHF...
  40. ncbi Burden of symptomatic dengue infection in children at primary school in Thailand: a prospective study
    Katie B Anderson
    Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    Lancet 369:1452-9. 2007
    ..Dengue viruses are a major cause of morbidity and mortality in tropical and subtropical areas. Our aim was to assess prospectively the burden of dengue-related illness in children in Thailand...
  41. ncbi Secreted complement regulatory protein clusterin interacts with dengue virus nonstructural protein 1
    Takeshi Kurosu
    Research Collaboration Center on Emerging and Re emerging Infections RCC ERI, Tiwanon Rd, Muang, Nonthaburi 11000, Thailand
    Biochem Biophys Res Commun 362:1051-6. 2007
    Vascular leakage and shock are the major causes of death in patients with dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS)...
  42. ncbi Dengue and dengue hemorrhagic fever among adults: clinical outcomes related to viremia, serotypes, and antibody response
    Adriana O Guilarde
    Instituto de Patologia Tropical e Saude Publica, Universidade Federal de Goias, Brazil
    J Infect Dis 197:817-24. 2008
    ..In Brazil, the disease burden predominantly affects adults, with an increasing trend toward progression to dengue hemorrhagic fever (DHF) noted.
  43. ncbi Co-circulations of two genotypes of dengue virus in 2006 out-break of dengue hemorrhagic fever in Karachi, Pakistan
    E Khan
    Department of Pathology and Microbiology, The Aga Khan University Hospital, Stadium Road, P O Box 3500, Karachi 74800, Pakistan
    J Clin Virol 43:176-9. 2008
    ..The status of dengue genotypes involved in the recent epidemic out-breaks in Pakistan is not well defined...
  44. ncbi Dengue and dengue hemorrhagic fever in the State of Pernambuco, 1995-2006
    Marli Tenório Cordeiro
    Laboratório Central de Saúde de Pública, Secretaria de Saúde do Estado de Pernambuco, Recife, PE, Brasil
    Rev Soc Bras Med Trop 40:605-11. 2007
    ..A total of 378,374 cases were notified, with 612 confirmed cases of dengue hemorrhagic fever and 33 deaths. The mortality rate was 5.4%...
  45. ncbi Clinical characteristics and risk factors for concurrent bacteremia in adults with dengue hemorrhagic fever
    Ing-Kit Lee
    Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Taiwan, Republic of China
    Am J Trop Med Hyg 72:221-6. 2005
    ..better understand the clinical characteristics of concurrent bacteremia (dual infection) in patients with dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) and identify predictive risk factors for dual infection, 100 patients ..
  46. ncbi Electrolyte disturbances and abnormal urine analysis in children with dengue infection
    Adisorn Lumpaopong
    Division of Pediatric Nephrology, Department of Pediatrics, Phramongkutklao Hospital, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 41:72-6. 2010
    ..and urine analysis results were retrospectively reviewed in children with either dengue fever (DF) or dengue hemorrhagic fever (DHF)...
  47. ncbi Allergies and diabetes as risk factors for dengue hemorrhagic fever: results of a case control study
    Maria Aparecida A Figueiredo
    State University of Bahia, Salvador, Brazil
    PLoS Negl Trop Dis 4:e699. 2010
    The physiopathology of dengue hemorrhagic fever (DHF), a severe form of Dengue Fever, is poorly understood...
  48. ncbi Implications of dynamic changes among tumor necrosis factor-alpha (TNF-alpha), membrane TNF receptor, and soluble TNF receptor levels in regard to the severity of dengue infection
    Lin Wang
    Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Kaohsiung, Taiwan, Republic of China
    Am J Trop Med Hyg 77:297-302. 2007
    ..TNF-alpha, membrane TNF receptors (mTNFR1 and mTNFR2), and sTNFR1 and sTNFR2 levels for patients with dengue hemorrhagic fever (DHF) and those not infected during a DEN-2 outbreak in southern Taiwan in 2002-2003...
  49. ncbi Surveillance for an emerging disease: dengue hemorrhagic fever in Puerto Rico, 1988-1997. Puerto Rico Association of Epidemiologists
    J G Rigau-Perez
    Dengue Branch, Centers for Disease Control and Prevention, San Juan, Puerto Rico 00921 3200
    P R Health Sci J 18:337-45. 1999
    ..The dengue hemorrhagic fever (DHF) surveillance system in Puerto Rico collects patient data from three sources: dengue case ..
  50. ncbi Clinical and epidemiological characterization of dengue hemorrhagic fever cases in northeastern, Brazil
    Luciano Pamplona de Góes Cavalcanti
    Graduate Program in Medical Sciences, Federal University of Ceara, Fortaleza, CE, Brazil
    Rev Soc Bras Med Trop 43:355-8. 2010
    ..The dengue hemorrhagic dengue (DHF) remains an important public health problem in Brazil. The objective of this study was to analyze the epidemiological characteristics of DHF cases during the 2003 epidemic in Ceará...
  51. ncbi Isolation and characterization of two phenotypically distinct dengue type-2 virus isolates from the same dengue hemorrhagic Fever patient
    Hitomi Kinoshita
    Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852 8523, Japan
    Jpn J Infect Dis 62:343-50. 2009
    ..The dengue virus antigen was detected in peripheral CD19+ cells (B cells) in one dengue hemorrhagic fever patient...
  52. ncbi Serious thrombocytopenia due to dengue hemorrhagic fever treated with high dosages of immunoglobulin
    M Ostronoff
    Clin Infect Dis 36:1623-4. 2003
  53. ncbi Two cases of self-limiting nephropathies secondary to dengue haemorrhagic fever
    F F Vasanwala
    Department of Family Medicine and Continuing Care, Singapore General Hospital, Outram Road, Singapore
    Singapore Med J 50:e253-5. 2009
    ..We postulate that this nephrotic-range proteinuria is a manifestation of increased glomerular leakage of protein, due to glomerulonephritis associated with dengue haemorrhagic fever...
  54. ncbi Correlation of disease spectrum among four Dengue serotypes: a five years hospital based study from India
    Rajni Kumaria
    Singapore MIT Alliance for Research and Technology, National University of Singapore, Singapore
    Braz J Infect Dis 14:141-6. 2010
    The recognition of DF (DHF Dengue Hemorrhagic Fever) is very complicated due to occurrence of a wide spectrum of clinical signs and symptoms during acute phase of illness...
  55. ncbi The emergence of epidemic dengue fever and dengue hemorrhagic fever in the Americas: a case of failed public health policy
    Duane Gubler
    Rev Panam Salud Publica 17:221-4. 2005
  56. ncbi Myocardial depression in dengue hemorrhagic fever: prevalence and clinical description
    Apichai Khongphatthanayothin
    Department of Pediatrics, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand
    Pediatr Crit Care Med 8:524-9. 2007
    To determine the prevalence of myocardial depression and its effect on the clinical severity in patients with dengue hemorrhagic fever.
  57. ncbi Prevalence of dengue fever and dengue hemorrhagic fever in Hospital Tengku Ampuan Rahimah, Klang, Selangor, Malaysia
    I Jamaiah
    Department of Parasitology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Southeast Asian J Trop Med Public Health 36:196-201. 2005
    Dengue fever and dengue hemorrhagic fever have been known to be endemic and reportable diseases in Malaysia since 1971. Major outbreaks occurred in 1973, 1982 and in 1998. For the past few decades until now...
  58. ncbi Dengue 1 virus and dengue hemorrhagic fever, French Polynesia, 2001
    Bruno Hubert
    Directorate of Health, Papeete, Tahiti, French Polynesia
    Emerg Infect Dis 15:1265-70. 2009
    ..Surveillance data from hospitalized case-patients showed that case-patients with dengue hemorrhagic fever (DHF) exhibited a bimodal age distribution with 1 peak among infants 6-10 months of age and a second peak ..
  59. ncbi A re-evaluation of the mechanisms leading to dengue hemorrhagic fever
    Sansanee Noisakran
    Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Ann N Y Acad Sci 1171:E24-35. 2009
    ..in a spectrum of clinical symptoms, ranging from undifferentiated flu-like illness, mild dengue fever, to dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS), a life-threatening illness...
  60. ncbi Dengue hemorrhagic fever: a rare cause of pituitary tumor hemorrhage and reversible vision loss
    Vimal Kumar
    Department of Neurosciences, Paras Hospital, Gurgaon, Haryana, India
    Indian J Ophthalmol 59:311-2. 2011
    b>Dengue hemorrhagic fever leading to hemorrhage in pituitary adenoma is not reported till date: We herein report the first case of bilateral visual loss secondary to pituitary adenoma hemorrhage associated with dengue hemorrhagic fever...
  61. ncbi MCP-1, a highly expressed chemokine in dengue haemorrhagic fever/dengue shock syndrome patients, may cause permeability change, possibly through reduced tight junctions of vascular endothelium cells
    Ying Ray Lee
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, 1 Da Shue Road, Tainan 701, Taiwan
    J Gen Virol 87:3623-30. 2006
    ....
  62. ncbi The climatic factors influencing the occurrence of dengue hemorrhagic fever in Thailand
    Suwich Thammapalo
    Bureau of Vector-borne Disease Control, Ministry of Public Health, Nonthaburi, Thailand
    Southeast Asian J Trop Med Public Health 36:191-6. 2005
    ..effects of climatic factors: rainfall, temperature and relative humidity, on the occurrence of dengue hemorrhagic fever (DHF) in Thailand after adjustment for cyclical pattern...
  63. ncbi Slower rates of clearance of viral load and virus-containing immune complexes in patients with dengue hemorrhagic fever
    Wei Kung Wang
    Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, 100, Taiwan
    Clin Infect Dis 43:1023-30. 2006
    ..an initial high level of dengue virus replication to the severe and potentially life-threatening diseases dengue hemorrhagic fever (DHF) and dengue shock syndrome, the involvement of dengue virus in the immunopathological processes ..
  64. ncbi Four dengue virus serotypes found circulating during an outbreak of dengue fever and dengue haemorrhagic fever in Jakarta, Indonesia, during 2004
    Agus Suwandono
    National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia
    Trans R Soc Trop Med Hyg 100:855-62. 2006
    ....
  65. ncbi Differences in global gene expression in peripheral blood mononuclear cells indicate a significant role of the innate responses in progression of dengue fever but not dengue hemorrhagic fever
    Sukathida Ubol
    Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand
    J Infect Dis 197:1459-67. 2008
    Dengue virus infection causes an array of symptoms ranging from dengue fever (DF) to dengue hemorrhagic fever (DHF). The pathophysiological processes behind these 2 clinical manifestations are unclear.
  66. ncbi [Clinical and epidemiological aspects of the dengue epidemic in Recife, PE, 2002]
    Demetrius Montenegro
    , , Recife, PE
    Rev Soc Bras Med Trop 39:9-13. 2006
    ..Vascular collapse (shock) was present in 12 (85.7%) cases, with or without the association of major bleeding, and was the most important cause of death...
  67. ncbi Clinical characteristics of dengue and dengue hemorrhagic fever in a medical center of southern Taiwan during the 2002 epidemic
    Min-Sheng Lee
    Division of Pediatric Infectious Disease, Department of Pediatrics, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Microbiol Immunol Infect 39:121-9. 2006
    ..PURPOSE: This study investigated the clinical manifestations and risk factors for dengue fever (DF) and dengue hemorrhagic fever (DHF) and disease severity during the 2002 outbreak in the Kaohsiung area...
  68. ncbi Dengue virus 3 genotype 1 associated with dengue fever and dengue hemorrhagic fever, Brazil
    Leandra Barcelos Figueiredo
    Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Emerg Infect Dis 14:314-6. 2008
    ..On the basis of phylogenetic analyses, these isolates were assigned genotype 1. This genotype had never been reported in South America before. Its appearance indicates a major risk factor for dengue epidemics and severe disease...
  69. ncbi Dengue and dengue hemorrhagic fever in northern Mexico and south Texas: do they really respect the border?
    Gary G Clark
    Am J Trop Med Hyg 78:361-2. 2008
  70. ncbi Management of severe dengue in children
    Christopher Moxon
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    Adv Exp Med Biol 609:131-44. 2008
    ....
  71. ncbi MBL2 gene polymorphisms protect against development of thrombocytopenia associated with severe dengue phenotype
    Bartolomeu Acioli-Santos
    Virology and Experimental Therapy Laboratory, Aggeu Magalhães Research Center CPqAM FIOCRUZ, Recife, Brazil
    Hum Immunol 69:122-8. 2008
    ..evolve from an asymptomatic and mild disease, known as dengue fever (DF), to a severe disease known as dengue hemorrhagic fever (DHF)...
  72. ncbi [Dengue, a growing problem of health in the Americas]
    Gustavo Kouri
    Rev Panam Salud Publica 19:143-5. 2006
  73. ncbi Characterization of atypical lymphocytes and immunophenotypes of lymphocytes in patients with dengue virus infection
    Wipawee Jampangern
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Asian Pac J Allergy Immunol 25:27-36. 2007
    ..infection, we performed flow cytometric analysis of peripheral blood mononuclear cells collected from 49 dengue hemorrhagic fever (DHF), 25 dengue fever (DF), and 26 dengue-like syndrome (DLS) cases...
  74. ncbi Studies on dengue and dengue haemorrhagic fever (DHF) in West Bengal State, India
    A K Hati
    School of Tropical Medicine and Hygiene, Kolkatta
    J Commun Dis 38:124-9. 2006
    ....
  75. ncbi Severe dengue virus infection in travelers: risk factors and laboratory indicators
    Ole Wichmann
    Institute of Tropical Medicine, Charite University Medicine, Berlin, Germany
    J Infect Dis 195:1089-96. 2007
    ..Data on severity and secondary infection rates in a population of travelers are lacking...
  76. ncbi Silent transmission of virus during a Dengue epidemic, Nakhon Pathom Province, Thailand 2001
    Thaval Poblap
    Nakhon Pathom Provincial Health Office, Ministry of Public Health, Nakhon Pathom, Thailand
    Southeast Asian J Trop Med Public Health 37:899-903. 2006
    In the year 2001 a large dengue fever (DF)/dengue hemorrhagic fever (DHF) outbreak occurred in Nakhon Pathom Province, Thailand. Three thousand one hundred twelve cases of DHF were reported, an attack rate of 393 per 100,000 population...
  77. ncbi Antibody responses are generated to immunodominant ELK/KLE-type motifs on the nonstructural-1 glycoprotein during live dengue virus infections in mice and humans: implications for diagnosis, pathogenesis, and vaccine design
    Andrew K I Falconar
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
    Clin Vaccine Immunol 14:493-504. 2007
    ..rabbits, similar antibody reaction profiles were generated by mice and humans with severe D-2V disease (dengue hemorrhagic fever [DHF]/dengue shock syndrome [DSS])...
  78. ncbi Laboratory-based dengue fever surveillance in Tamil Nadu, India
    T John Victor
    Institute of Vector Control and Zoonoses, Hosur, India
    Indian J Med Res 126:112-5. 2007
    ....
  79. ncbi Serodiagnosis of dengue virus infection in patients presenting to a tertiary care hospital
    M Neeraja
    Department of Microbiology, Nizam s Institute of Medical Sciences, Punjagutta, Hyderabad 500 082, Andhra Pradesh, India
    Indian J Med Microbiol 24:280-2. 2006
    ..The spectrum of disease ranges from self-limited dengue fever to more severe forms of dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS)...
  80. ncbi Dengue fever: what hope for control?
    Kathryn Senior
    Lancet Infect Dis 7:636. 2007
  81. ncbi [Low concordance between early clinical suspicion of dengue and its serological confirmation]
    Ruth Aralí Martinez-Vega
    Centro de Investigaciones Epidemiológicas, Universidad Industrial de Santander, Bucaramanga, Colombia
    Rev Med Chil 134:1153-60. 2006
    ..Early detection of dengue could help to prevent its complications. The usefulness of clinical criteria for diagnosis of the disease must be ascertained...
  82. ncbi Clinical profile and outcome of hospitalized patients during first outbreak of dengue in Makkah, Saudi Arabia
    Nasim A Khan
    Division of Rheumatology, University of Arkansas for Medical Sciences, Mail Slot 509, 4301 West Markham, Little Rock, AR 72205, USA
    Acta Trop 105:39-44. 2008
    ..To describe clinical profile of patients with dengue virus infection hospitalized at a single center during the first outbreak of dengue in Makkah, Saudi Arabia from April to July 2004...
  83. ncbi Primary and secondary infections of Macaca fascicularis monkeys with Asian and American genotypes of dengue virus 2
    Lidice Bernardo
    Department of Virology, PAHO WHO Collaborating Center for the Study of Dengue and its Vector, Pedro Kouri Tropical Medicine Institute, Autopista Novia del Mediodia, km 6 1 2, P O Box 601, Marianao 13, Havana, Cuba
    Clin Vaccine Immunol 15:439-46. 2008
    ..Despite the demonstration of the protective effect after homologous challenge, a strong anamnestic antibody response was observed...
  84. ncbi Implications of previous subclinical dengue infection but not virus load in dengue hemorrhagic fever
    Wen-Ting Yeh
    Department of Medical Research, Chang Gung Memorial Hospital at Kaohsiung, Chang Gung University College of Medicine, Niau-Sung, Kaohsiung, Taiwan
    FEMS Immunol Med Microbiol 48:84-90. 2006
    ..013) than those with primary infection. Patients with secondary DEN-2 infection also had a higher rate of dengue hemorrhagic fever (DHF) (61.7% vs. 36.3%)...
  85. ncbi Temporal distribution of dengue virus serotypes in Colombian endemic area and dengue incidence. Re-introduction of dengue-3 associated to mild febrile illness and primary infection
    Raquel Elvira Ocazionez
    Centro de Investigaciones en Enfermedades Tropicales, Escuela de Medicina, Universidad Industrial de Santander, Santander, Colombia
    Mem Inst Oswaldo Cruz 101:725-31. 2006
    ..Predominance of DEN-2 in 2000-2001 coincided with more dengue hemorrhagic fever (DHF). DEN-4 was isolated in 2000-2001 and 2004 but was not predominant...
  86. ncbi [Aminotransferases serum levels in patients with Dengue type 3]
    Nereida Valero C
    Seccion de Virologia, Instituto de Investigaciones Clinicas Dr Americo Negrette, Universidad del Zulia, Maracaibo, Zulia, Venezuela
    Rev Med Chil 135:1304-12. 2007
    ..Dengue infections may affect the liver, causing inflammation and compromising its function...
  87. ncbi Role of T cells, cytokines and antibody in dengue fever and dengue haemorrhagic fever
    Joshua Fink
    Novartis Institute for Tropical Diseases, 10 Biopolis Road, 05-01 Chromos, Singapore
    Rev Med Virol 16:263-75. 2006
    ..The need for effective measures against dengue and dengue-related illness is clear. We propose that drugs against dengue virus, or the symptoms of severe dengue disease, are a viable goal...
  88. ncbi [Final characterization of and lessons learned from the dengue 3 epidemic in Cuba, 2001-2002]
    Maria G Guzman
    Centro Colaborador OPS OMS para el Estudio del Dengue y su Vector, Instituto de Medicina Tropical Pedro Kouri, Ciudad de La Habana, Cuba
    Rev Panam Salud Publica 19:282-9. 2006
  89. ncbi [Dengue and dengue hemorrhagic fever: research priorities]
    Maria G Guzman
    Instituto de Medicina Tropical Pedro Kouri, Ciudad de La Habana, Cuba
    Rev Panam Salud Publica 19:204-15. 2006
    ....
  90. ncbi Prospective study to determine accuracy of rapid serological assays for diagnosis of acute dengue virus infection in Laos
    Stuart D Blacksell
    Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
    Clin Vaccine Immunol 14:1458-64. 2007
    ..The findings of this study suggest that currently available RDTs based on the detection of IgM antibodies for the diagnosis of acute dengue virus infections are unlikely to be useful for patient management...
  91. ncbi Evaluation of RT-PCR as a tool for diagnosis of secondary dengue virus infection
    Areerat Sa-ngasang
    National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi 11000, Thailand
    Jpn J Infect Dis 56:205-9. 2003
    Dengue fever and dengue hemorrhagic fever are serious illnesses in many tropical and subtropical countries. Laboratory tests are essential for the confirmation of dengue virus infection...
  92. ncbi Dengue viral infections
    G N Malavige
    Department of Clinical Immunology, A Floor, West Block, Queens Medical Centre, University Hospital, Nottingham NG7 2UH, UK
    Postgrad Med J 80:588-601. 2004
    ..This review outlines aspects of the epidemiology of dengue infections, the dengue virus and its mosquito vector, clinical features and pathogenesis of dengue infections, and the management and control of these infections...
  93. ncbi Nucleotide sequence and phylogenetic analyses of dengue type 2 virus isolated in the Dominican Republic
    Saburo Anzai
    Department of Infectious Diseases, Faculty of Medicine, Oita University, Oita 879 5593, Japan
    Virus Genes 29:219-27. 2004
    ..DEN-2) virus, DR23/01 and DR31/01 isolated from dengue fever (DF) patients, and DR59/01 isolated from a dengue hemorrhagic fever (DHF) patient, all with primary infection, in the Dominican Republic in 2001, have been established...
  94. ncbi Clinical diagnosis and assessment of severity of confirmed dengue infections in Vietnamese children: is the world health organization classification system helpful?
    Cao Xuan Thanh Phuong
    Dong Nai Paediatric Centre, Dong Nai Province, Bien Hoa, Vietnam
    Am J Trop Med Hyg 70:172-9. 2004
    ..Mucosal bleeding was observed with equal frequency in those with dengue fever and dengue hemorrhagic fever (DHF), and petechiae, thrombocytopenia, and the tourniquet test differentiated poorly between the two ..
  95. ncbi Dengue virus: break-bone fever
    Tom Clarke
    Nature 416:672-4. 2002
  96. ncbi Quality control assessment for the serological diagnosis of dengue virus infections
    Oliver Donoso Mantke
    Robert Koch-Institut, Nordufer 20, 13353 Berlin, Germany
    J Clin Virol 29:105-12. 2004
    ..CONCLUSIONS: The results presented here demonstrate the importance of quality measures for imported viral pathogens like dengue viruses and clearly indicate the need for improving the existing test systems...
  97. ncbi Dengue fever in the Western Hemisphere
    Jason S Castleberry
    University of Texas, San Antonio, TX, USA
    Clin Lab Sci 16:34-8. 2003
    Dengue virus, an arthropod-borne viral agent, causes two distinct diseases: classic dengue fever (DF) and dengue hemorrhagic fever (DHF). There are four dengue virus serotypes: DEN-1, DEN-2, DEN-3, and DEN-4...
  98. ncbi Cities spawn epidemic dengue viruses
    Duane J Gubler
    Nat Med 10:129-30. 2004
  99. ncbi Antibodies from dengue patient sera cross-react with endothelial cells and induce damage
    Chiou-Feng Lin
    Department of Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan, Republic of China
    J Med Virol 69:82-90. 2003
    ..causes a wide range of diseases from the mild febrile illness dengue fever to the life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS)...
  100. ncbi Epidemiology of dengue in Sri Lanka before and after the emergence of epidemic dengue hemorrhagic fever
    William B Messer
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill 27599, USA
    Am J Trop Med Hyg 66:765-73. 2002
    ..Sri Lanka was characterized by frequent transmission of all four dengue serotypes but a low incidence of dengue hemorrhagic fever (DHF). After 1989, cases of DHF dramatically increased...
  101. ncbi Dengue: an update
    Maria G Guzman
    Virology Department, PAHO WHO Collaborating Center for Viral Diseases, Pedro Kouri Tropical Medicine Institute, Autopista Novia del Mediodia, Km 6, PO Box Marianao 13, Ciudad Habana, Cuba
    Lancet Infect Dis 2:33-42. 2002
    ..We describe the status of vaccine development and emphasise that the only alternative that we have today to control the disease is through control of its vector Aedes aegypti...

Research Grants74

  1. Inhibition of the Membrane Fusion Proteins of Flaviviruses and Alphaviruses
    Margaret Kielian; Fiscal Year: 2007
    ..are an estimated 50-100 million cases of dengue fever and 500,000 cases of the more lethal complication dengue hemorrhagic fever per year, with significant impact on both human health and the economies of developing countries...
  2. Mechanisms of sylvatic dengue emergence
    Scott C Weaver; Fiscal Year: 2010
    ..DENV infects 100 million people per year in over 100 countries, causing classical dengue fever as well as dengue hemorrhagic fever and dengue shock syndrome, while CHIKV has caused recent epidemics involving over 2 million persons with ..
  3. Mechanisms of sylvatic dengue emergence
    Scott Weaver; Fiscal Year: 2009
    ..DENV infects 100 million people per year in over 100 countries, causing classical dengue fever as well as dengue hemorrhagic fever and dengue shock syndrome, while CHIKV has caused recent epidemics involving over 2 million persons with ..
  4. Dengue Epitope Vaccine,Tetravalent & MHCII-Targeted
    J Thomas August; Fiscal Year: 2007
    ..both for their possible role in prevention of infection and proposed negative role in the etiology of dengue hemorrhagic fever. A human ex vivo T-cell activation assay will be used to analyze the biological correlates of the ..
  5. FUNCTIONAL ANALYSIS OF DENGUE VIRUS ANTIGENS NS3 AND NS5
    Radhakrishnan Padmanabhan; Fiscal Year: 1993
    ..Apart from dengue fever, a more severe and fatal form of the disease occurs in children called dengue hemorrhagic fever, or the dengue shock syndrome...
  6. A VEE Replicon-Based Vaccine for Dengue Virus
    Laura White; Fiscal Year: 2006
    ..emerging pathogens, infects humans causing a spectrum of clinical manifestations including dengue fever, dengue hemorrhagic fever and dengue shock syndrome...
  7. FUNCTIONAL ANALYSIS OF DENGUE VIRUS ANTIGENS NS3 AND NS5
    Radhakrishnan Padmanabhan; Fiscal Year: 2003
    ..Of these, more than 250,000 cases involve life threatening dengue hemorrhagic fever / dengue shock syndrome...
  8. Fitness and Virulence of Dengue Virus in the Context of Changing Host Immunity
    Eva Harris; Fiscal Year: 2010
    ..DENV infection results in dengue fever, an acute febrile illness, or the more severe, life- threatening dengue hemorrhagic fever/dengue shock syndrome...
  9. STRUCTURE BASED ANALYSIS OF DENGUE VIRUS SERINE PROTEASE
    Krishna Murthy; Fiscal Year: 2004
    ..Of these, more than 250,000 cases involve life-threatening dengue hemorrhagic fever/dengue shock syndrome with no effective chemotherapy or vaccine currently available...
  10. Flavivirus Infections: Pathogenesis and Prevention
    Francis Ennis; Fiscal Year: 2007
    The major goal of this Program Project is to understand the immunopathology of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), the severe complications of dengue virus infections...
  11. Validation of Src kinases as Anti-Dengue Viral Targets
    PRISCILLA LI NING YANG; Fiscal Year: 2010
    ..These small molecules can then be used to study how dengue virus interacts with its host and to develop therapies for the treatment of dengue virus infections. ..
  12. Validation of Src kinases as Anti-Dengue Viral Targets
    PRISCILLA LI NING YANG; Fiscal Year: 2010
    ..These small molecules can then be used to study how dengue virus interacts with its host and to develop therapies for the treatment of dengue virus infections. ..
  13. Determinants of protection and enhancement of dengue infection/disease in vivo
    Eva Harris; Fiscal Year: 2010
    ..DENV infection results in dengue fever, an acute febrile illness, or the more severe, life- threatening dengue hemorrhagic fever/dengue shock syndrome...
  14. Rapid antigen detection test for Dengue infection
    Raymond Houghton; Fiscal Year: 2007
    ..million new case of Dengue infection per year, up to half a million of which progress to life-threatening Dengue Hemorrhagic Fever. Dengue is classified by NIAID as a re-emerging pathogen and a Category A biodefense agent...
  15. Dengue vaccine and viral evolution in rural Thailand
    TIMOTHY PAUL ENDY; Fiscal Year: 2010
    ..200 years as four distinct serotypes and an important human pathogen producing severe illness known as dengue hemorrhagic fever (DHF). Dengue is considered an emerged global public health problem...
  16. Antibody-Based Protection Against Dengue Virus
    Michael Diamond; Fiscal Year: 2007
    ..the four serotypes of DENV cause an estimated 100 million new cases of dengue fever and 250,000 cases of dengue hemorrhagic fever (DHF) per year...
  17. RNA-Protein Interactions in Flavivirus Infection
    MARIANO GARCIA BLANCO; Fiscal Year: 2007
    ..A conservative estimate of the population at risk is a staggering 2.5 billion people. DF can progress to dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), which are dreaded developments...
  18. Antibody-Based Protection Against Dengue Virus
    Michael S Diamond; Fiscal Year: 2010
    ..the four serotypes of DENV cause an estimated 100 million new cases of dengue fever and 250,000 cases of dengue hemorrhagic fever (DHF) per year...
  19. CONTROL OF URBAN CONTAINER BREEDING ARBROVIRUS VECTORS
    Dawn Wesson; Fiscal Year: 2007
    Emerging viral diseases, such as dengue hemorrhagic fever and West Nile viral encephalitis, pose a significant threat to public health...
  20. INTERFERENCE TO DENGUE VIRUS REPLICATION IN MOSQUITOES
    Carol Blair; Fiscal Year: 2006
    ..About 50-100 million cases of dengue fever (DF) and >100,000 cases of life-threatening dengue hemorrhagic fever (DHF) occur annually worldwide...
  21. Dengue Epitope. Tetravalent. MHC II Targeted DNA Vaccine
    J August; Fiscal Year: 2003
    ..hot-spot sequences will also be tested ex vivo for their possible anti-viral role or correlation with dengue hemorrhagic fever. The vaccine formulation will exclude unnecessary or deleterious dengue sequences, particularly those MHC ..
  22. Dengue Reporter Virus Neutralization Assay for Clinical Studies
    Eva Harris; Fiscal Year: 2007
    ..resulting in an estimated 50 million cases of dengue fever and over 450,000 cases of life-threatening dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) each year...