dengue hemorrhagic fever

Summary

Summary: A distinct and virulent form of DENGUE characterized by thrombocytopenia and hemoconcentration (grades I and II) and distinguished by a positive tourniquet test. When accompanied by circulatory failure and shock (grades III and IV), it is called dengue shock syndrome. (From Dorland, 28th ed)

Top Publications

  1. pmc Dengue and dengue hemorrhagic fever
    D J Gubler
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
    Clin Microbiol Rev 11:480-96. 1998
  2. ncbi Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century
    Duane J Gubler
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Dept of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA
    Trends Microbiol 10:100-3. 2002
  3. ncbi Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever
    Juthathip Mongkolsapaya
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DS, UK
    Nat Med 9:921-7. 2003
  4. ncbi Serotype-specific dengue virus circulation and dengue disease in Bangkok, Thailand from 1973 to 1999
    Ananda Nisalak
    Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Am J Trop Med Hyg 68:191-202. 2003
  5. ncbi Predictive value of simple clinical and laboratory variables for dengue hemorrhagic fever in adults
    Vernon J Lee
    Department of Clinical Epidemiology, Tan Tock Seng Hospital, Singapore
    J Clin Virol 42:34-9. 2008
  6. ncbi Clinical and laboratory characteristics and risk factors for fatality in elderly patients with dengue hemorrhagic fever
    Ing Kit Lee
    Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien, Taiwan
    Am J Trop Med Hyg 79:149-53. 2008
  7. ncbi Differing influences of virus burden and immune activation on disease severity in secondary dengue-3 virus infections
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Infect Dis 185:1213-21. 2002
  8. pmc Murine model for dengue virus-induced lethal disease with increased vascular permeability
    Sujan Shresta
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    J Virol 80:10208-17. 2006
  9. pmc DC-SIGN (CD209) Promoter -336 A/G polymorphism is associated with dengue hemorrhagic fever and correlated to DC-SIGN expression and immune augmentation
    Lin Wang
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center CGMH KMC, Kaohsiung, Taiwan
    PLoS Negl Trop Dis 5:e934. 2011
  10. doi Antibodies determine virulence in dengue
    Scott B Halstead
    Supportive Research and Development Program, Pediatric Dengue Vaccine Initiative, Bethesda, Maryland 20852, USA
    Ann N Y Acad Sci 1171:E48-56. 2009

Detail Information

Publications282 found, 100 shown here

  1. pmc Dengue and dengue hemorrhagic fever
    D J Gubler
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
    Clin Microbiol Rev 11:480-96. 1998
    ..the development of hyperendemicity (the cocirculation of multiple serotypes), and the emergence of dengue hemorrhagic fever in new geographic regions...
  2. ncbi Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century
    Duane J Gubler
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Dept of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA
    Trends Microbiol 10:100-3. 2002
    Dengue fever/dengue hemorrhagic fever is now one of the most important public health problems in tropical developing countries and also has major economic and societal consequences.
  3. ncbi Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever
    Juthathip Mongkolsapaya
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DS, UK
    Nat Med 9:921-7. 2003
    ..Four major serotypes of dengue virus have been characterized, and epidemiological evidence shows that dengue hemorrhagic fever (DHF), the more serious manifestation of the disease, occurs more frequently upon reinfection with a ..
  4. ncbi Serotype-specific dengue virus circulation and dengue disease in Bangkok, Thailand from 1973 to 1999
    Ananda Nisalak
    Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Am J Trop Med Hyg 68:191-202. 2003
    ..DEN-3 was the most frequent serotype in primary dengue (49% of all isolates), DEN-2 in secondary and in dengue hemorrhagic fever (37% and 35%, respectively)...
  5. ncbi Predictive value of simple clinical and laboratory variables for dengue hemorrhagic fever in adults
    Vernon J Lee
    Department of Clinical Epidemiology, Tan Tock Seng Hospital, Singapore
    J Clin Virol 42:34-9. 2008
    ..Singapore experienced its worst dengue outbreak in 30 years in 2004, with 9459 notified cases, of which 83% were hospitalized...
  6. ncbi Clinical and laboratory characteristics and risk factors for fatality in elderly patients with dengue hemorrhagic fever
    Ing Kit Lee
    Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien, Taiwan
    Am J Trop Med Hyg 79:149-53. 2008
    ..and laboratory characteristics and to identify risk factor(s) for fatality in elderly patients with dengue hemorrhagic fever (DHF), 66 elderly (age > or = 65 years) and 241 non-elderly adults (age, 19-64 years) with DHF were ..
  7. ncbi Differing influences of virus burden and immune activation on disease severity in secondary dengue-3 virus infections
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Infect Dis 185:1213-21. 2002
    b>Dengue hemorrhagic fever (DHF), the most severe form of illness following infection with a dengue virus, is characterized by plasma leakage, thrombocytopenia, and hepatic inflammation...
  8. pmc Murine model for dengue virus-induced lethal disease with increased vascular permeability
    Sujan Shresta
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    J Virol 80:10208-17. 2006
    Lack of an appropriate animal model for dengue virus (DEN), which causes dengue fever and dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), has impeded characterization of the mechanisms underlying the disease pathogenesis...
  9. pmc DC-SIGN (CD209) Promoter -336 A/G polymorphism is associated with dengue hemorrhagic fever and correlated to DC-SIGN expression and immune augmentation
    Lin Wang
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center CGMH KMC, Kaohsiung, Taiwan
    PLoS Negl Trop Dis 5:e934. 2011
    ..We reason that variations in the DC-SIGN gene might have a broad influence on viral replication and host immune responses...
  10. doi Antibodies determine virulence in dengue
    Scott B Halstead
    Supportive Research and Development Program, Pediatric Dengue Vaccine Initiative, Bethesda, Maryland 20852, USA
    Ann N Y Acad Sci 1171:E48-56. 2009
    Four dengue viruses (DENV) cause syndromes that are self-limited or severe. The severe syndrome, dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), characterized by sudden vascular permeability, is not caused by inherently virulent ..
  11. pmc Dengue: an escalating problem
    Robert V Gibbons
    Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    BMJ 324:1563-6. 2002
  12. pmc Decision tree algorithms predict the diagnosis and outcome of dengue fever in the early phase of illness
    Lukas Tanner
    Novartis Institute for Tropical Diseases, Singapore
    PLoS Negl Trop Dis 2:e196. 2008
    ..Here we report the identification of algorithms that differentiate dengue from other febrile illnesses in the primary care setting and predict severe disease in adults...
  13. ncbi Dengue and dengue hemorrhagic fever in the Americas: lessons and challenges
    Maria G Guzman
    Virology Department, PAHO WHO Collaborating Center for Viral Diseases, Pedro Kouri Tropical Medicine Institute, Autopista Novia del Mediodia, Km 6 P O Box Marianao 13, Havana, Cuba
    J Clin Virol 27:1-13. 2003
    The incidence of dengue and dengue hemorrhagic fever (DF/DHF) has increased significantly over the last decades. Yearly, an estimated 50-100 million cases of DF and about 250000-500000 cases of DHF occur worldwide...
  14. ncbi High levels of plasma dengue viral load during defervescence in patients with dengue hemorrhagic fever: implications for pathogenesis
    Wei Kung Wang
    Institute of Microbiology, College of Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
    Virology 305:330-8. 2003
    Studies of the pathogenesis of dengue hemorrhagic fever (DHF), a potentially life-threatening disease, have revealed the importance of initial high levels of virus replication...
  15. ncbi Dengue hemorrhagic fever with special emphasis on immunopathogenesis
    Ichiro Kurane
    Department of Virology 1, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Comp Immunol Microbiol Infect Dis 30:329-40. 2007
    ..Dengue virus infection can be asymptomatic or causes two forms of illness, dengue fever (DF) and dengue hemorrhagic fever (DHF), which is the severe form of dengue illness and often fatal...
  16. doi Multiple dengue serotypes and high frequency of dengue hemorrhagic fever at two tertiary care hospitals in Lahore during the 2008 dengue virus outbreak in Punjab, Pakistan
    Malik Asif Humayoun
    Department of Medicine, Allama Iqbal Medical College and Jinnah Hospital, Maulana Shabbir Ahmed Usmani Road, Lahore, Punjab, Pakistan
    Int J Infect Dis 14:e54-9. 2010
    ..The objective of this study was to investigate the clinical characteristics of patients with dengue viral infection during the 2008 outbreak in Lahore in order to better understand the clinical pattern and severity of disease in Lahore...
  17. ncbi [Economic impact of dengue and dengue hemorrhagic fever in the State of Zulia, Venezuela, 1997-2003]
    Germán Añez
    Seccion de Virologia, Instituto de Investigaciones Clinicas Dr Americo Negrette, Facultad de Medicina, Universidad del Zulia, Maracaibo, Estado Zulia, Venezuela
    Rev Panam Salud Publica 19:314-20. 2006
    To determine the direct and indirect costs of medical care provided to cases of dengue and dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) between 1997 and 2003 in Zulia State, Venezuela.
  18. pmc Protective and enhancing HLA alleles, HLA-DRB1*0901 and HLA-A*24, for severe forms of dengue virus infection, dengue hemorrhagic fever and dengue shock syndrome
    Thi Phuong Lan Nguyen
    Department of Immunogenetics, Institute of Tropical Medicine NEKKEN, Nagasaki University, Japan
    PLoS Negl Trop Dis 2:e304. 2008
    ..Recently, the severe forms, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), have become the leading cause of death among children in Southern ..
  19. ncbi Slower rates of clearance of viral load and virus-containing immune complexes in patients with dengue hemorrhagic fever
    Wei Kung Wang
    Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, 100, Taiwan
    Clin Infect Dis 43:1023-30. 2006
    ..an initial high level of dengue virus replication to the severe and potentially life-threatening diseases dengue hemorrhagic fever (DHF) and dengue shock syndrome, the involvement of dengue virus in the immunopathological processes ..
  20. pmc Patterns of host genome-wide gene transcript abundance in the peripheral blood of patients with acute dengue hemorrhagic fever
    Cameron P Simmons
    Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
    J Infect Dis 195:1097-107. 2007
    Responses by peripheral blood leukocytes may contribute to the pathogenesis of dengue hemorrhagic fever (DHF). We used DNA microarrays to reveal transcriptional patterns in the blood of 14 adults with DHF...
  21. ncbi Cytokine cascade in dengue hemorrhagic fever: implications for pathogenesis
    U C Chaturvedi
    Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait
    FEMS Immunol Med Microbiol 28:183-8. 2000
    Dengue virus produces a mild acute febrile illness, dengue fever (DF) and a severe illness, dengue hemorrhagic fever (DHF)...
  22. ncbi HLA-A and -B allele associations with secondary dengue virus infections correlate with disease severity and the infecting viral serotype in ethnic Thais
    H A F Stephens
    Institute of Urology and Nephrology, University College, London, UK
    Tissue Antigens 60:309-18. 2002
    ..Appropriate paradigms for immunogenetic studies of acute viral infections are dengue fever (DF) and dengue hemorrhagic fever (DHF)...
  23. ncbi Strong HLA class I--restricted T cell responses in dengue hemorrhagic fever: a double-edged sword?
    H Loke
    Nuffield Department of Medicine, John Radcliffe Hospital and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    J Infect Dis 184:1369-73. 2001
    ..In a large case-control study of Vietnamese patients with dengue hemorrhagic fever (DHF), variation at the HLA-A locus was significantly associated with susceptibility to DHF (P=...
  24. ncbi Effect of age on outcome of secondary dengue 2 infections
    Maria G Guzman
    Department of Virology, PAHO WHO Collaborating Center for Viral Diseases, Tropical Medicine Institute of Havana, Cuba
    Int J Infect Dis 6:118-24. 2002
    b>Dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) is a growing global health problem. It is not known how age affects the outcome of secondary dengue infections...
  25. ncbi Dengue hemorrhagic Fever caused by sequential dengue 1-3 virus infections over a long time interval: Havana epidemic, 2001-2002
    Mayling Alvarez
    Department of Virology, Pan American Health Organization World Health Organization Collaborating Center for the Study of Dengue and its Vector, Pedro Kouri Tropical Medicine Institute, Havana, Cuba
    Am J Trop Med Hyg 75:1113-7. 2006
    A dengue epidemic caused by dengue virus 3 (DENV-3) occurred in Cuba in 2001-2002. It included cases of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS)...
  26. ncbi Severe dengue: the need for new case definitions
    José G Rigau-Pérez
    Dengue Branch, Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, San Juan, PR, USA
    Lancet Infect Dis 6:297-302. 2006
    ..In addition, for an accurate estimation of dengue burden, locally appropriate definitions of severe dengue must be devised and standardised so they will be considered valid in the global research community...
  27. pmc Recent shift in age pattern of dengue hemorrhagic fever, Brazil
    Maria Gloria Teixeira
    Emerg Infect Dis 14:1663. 2008
  28. ncbi Epidemiology of dengue and dengue hemorrhagic fever in a cohort of adults living in Bandung, West Java, Indonesia
    Kevin R Porter
    Viral Diseases Program, Naval Medical Research Unit No 2, Jakarta, Indonesia
    Am J Trop Med Hyg 72:60-6. 2005
    A prospective study of dengue fever (DF) and dengue hemorrhagic fever (DHF) was conducted in a cohort of adult volunteers from two textile factories located in West Java, Indonesia...
  29. ncbi Dengue: an update
    Maria G Guzman
    Virology Department, PAHO WHO Collaborating Center for Viral Diseases, Pedro Kouri Tropical Medicine Institute, Autopista Novia del Mediodia, Km 6, PO Box Marianao 13, Ciudad Habana, Cuba
    Lancet Infect Dis 2:33-42. 2002
    ..We describe the status of vaccine development and emphasise that the only alternative that we have today to control the disease is through control of its vector Aedes aegypti...
  30. ncbi Failure of secondary infection with American genotype dengue 2 to cause dengue haemorrhagic fever
    D M Watts
    Naval Medical Research Center Detachment, AMEMB NAMRID, Unit 3800, Lima, Peru
    Lancet 354:1431-4. 1999
    ..Possibly American DEN-2 genotype strains lacked properties necessary to cause severe disease. We report on a major epidemic of DEN-2 in Peru in 1995, about 5 years after an epidemic of DEN-1 in the same population...
  31. ncbi Dengue and dengue haemorrhagic fever
    J G Rigau-Perez
    Dengue Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, San Juan, Puerto Rico 00921 3200, USA
    Lancet 352:971-7. 1998
    ..Biological and social research are essential to develop effective mosquito control, medications to reduce capillary leakage, and a safe tetravalent vaccine...
  32. ncbi Classifying dengue: a review of the difficulties in using the WHO case classification for dengue haemorrhagic fever
    Shibani Bandyopadhyay
    Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Trop Med Int Health 11:1238-55. 2006
    ..Dengue has extended to different tropical areas and older age groups. Variations from the original description of dengue manifestations are being reported...
  33. ncbi Fatal dengue hemorrhagic fever in adults during a dengue epidemic in Singapore
    Adrian Ong
    Department of Infectious Diseases, Tan Tock Seng Hospital, 11 Jln Tan Tock Seng, 308433 Singapore
    Int J Infect Dis 11:263-7. 2007
    ..Associated with the rise of dengue has been the increase in dengue-associated mortality. To better understand the predictors of mortality, we conducted a review of hospitalized adult dengue infections within our institution...
  34. ncbi Early CD69 expression on peripheral blood lymphocytes from children with dengue hemorrhagic fever
    S Green
    Center for Infectious Disease, University of Massachusetts, Worcester, MA, USA
    J Infect Dis 180:1429-35. 1999
    Recent reports have demonstrated immune activation in dengue hemorrhagic fever (DHF) by cytokine and soluble receptor detection in blood...
  35. ncbi Autoimmune pathogenesis in dengue virus infection
    Chiou Feng Lin
    Department of Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan
    Viral Immunol 19:127-32. 2006
    The pathogenic mechanisms of dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS) caused by dengue virus (DV) infection remain unresolved...
  36. pmc A three-component biomarker panel for prediction of dengue hemorrhagic fever
    Allan R Brasier
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA
    Am J Trop Med Hyg 86:341-8. 2012
    Dengue virus infections are a major cause of morbidity in tropical countries. Early detection of dengue hemorrhagic fever (DHF) may help identify individuals that would benefit from intensive therapy...
  37. pmc Dengue epidemic in southern Vietnam, 1998
    D Q Ha
    Pasteur Institute, Ho Chi Minh City, Vietnam
    Emerg Infect Dis 6:422-5. 2000
    A widespread epidemic of dengue hemorrhagic fever (DHF) occurred in southern Vietnam in 1998, with 438.98 cases/100,000 population and 342 deaths. The number of DHF cases and deaths per 100,000 population increased 152.4% and 151...
  38. pmc Discovery proteomics and nonparametric modeling pipeline in the development of a candidate biomarker panel for dengue hemorrhagic fever
    Allan R Brasier
    Department of Internal Medicine, University of Texas Medical Branch UTMB, Galveston, Texas, USA
    Clin Transl Sci 5:8-20. 2012
    ..Secondary dengue viral infection can produce capillary leakage associated with increased mortality known as dengue hemorrhagic fever (DHF)...
  39. doi Outcome of dengue hemorrhagic fever-caused acute kidney injury in Thai children
    Kamolwish Laoprasopwattana
    Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand
    J Pediatr 157:303-9. 2010
    To examine the outcome of acute kidney injury (AKI) in children with dengue hemorrhagic fever (DHF), the cause(s) of AKI, and the risk of AKI and fatality.
  40. doi Acute myocarditis in dengue hemorrhagic fever: a case report and review of cardiac complications in dengue-affected patients
    Ing Kit Lee
    Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Taiwan
    Int J Infect Dis 14:e919-22. 2010
    We report a case of dengue hemorrhagic fever (DHF) complicated by acute myocarditis and review the literature...
  41. ncbi Clinical characteristics of dengue and dengue hemorrhagic fever in a medical center of southern Taiwan during the 2002 epidemic
    Min Sheng Lee
    Division of Pediatric Infectious Disease, Department of Pediatrics, Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Microbiol Immunol Infect 39:121-9. 2006
    This study investigated the clinical manifestations and risk factors for dengue fever (DF) and dengue hemorrhagic fever (DHF) and disease severity during the 2002 outbreak in the Kaohsiung area.
  42. doi Dengue hemorrhagic fever and shock syndromes
    Suchitra Ranjit
    Pediatric Intensive Care Unit, Apollo Children s Hospital, Chennai, India
    Pediatr Crit Care Med 12:90-100. 2011
    ..Dengue, a leading cause of childhood mortality in Asia and South America, is the most rapidly spreading and important arboviral disease in the world and has a geographic distribution of > 100 countries...
  43. pmc Virus-induced decline in soluble vascular endothelial growth receptor 2 is associated with plasma leakage in dengue hemorrhagic Fever
    Anon Srikiatkhachorn
    Center for Infectious Diseases and Vaccine Research, Rm S5 326, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 0002, USA
    J Virol 81:1592-600. 2007
    Some individuals infected with dengue virus develop dengue hemorrhagic fever (DHF), a viral hemorrhagic disease characterized by a transient period of localized plasma leakage...
  44. ncbi Pathologic study of a fatal case of dengue-3 virus infection in Rio de Janeiro, Brazil
    C A Basilio-de-Oliveira
    Gaffrée and Guinle Teaching Hospital, Federal University of Rio de Janeiro, Brazil
    Braz J Infect Dis 9:341-7. 2005
    b>Dengue hemorrhagic fever (DHF) is a severe febrile disease, characterized by abnormalities in hemostasis and increased vascular permeability, which in some cases results in hypovolemic shock syndrome and in dengue shock syndrome...
  45. pmc Relationship between transmission intensity and incidence of dengue hemorrhagic fever in Thailand
    Suwich Thammapalo
    Bureau of Vector Borne Disease, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand
    PLoS Negl Trop Dis 2:e263. 2008
    Dengue is the most prevalent mosquito-borne virus, and potentially fatal dengue hemorrhagic fever (DHF) occurs mainly in secondary infections...
  46. ncbi Comparison of three fluid solutions for resuscitation in dengue shock syndrome
    Bridget A Wills
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    N Engl J Med 353:877-89. 2005
    ..Although volume replacement is recognized as the critical therapeutic intervention, World Health Organization management guidelines remain empirical rather than evidence-based...
  47. ncbi Isolation and characterization of two phenotypically distinct dengue type-2 virus isolates from the same dengue hemorrhagic Fever patient
    Hitomi Kinoshita
    Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852 8523, Japan
    Jpn J Infect Dis 62:343-50. 2009
    ..The dengue virus antigen was detected in peripheral CD19+ cells (B cells) in one dengue hemorrhagic fever patient...
  48. pmc Allergies and diabetes as risk factors for dengue hemorrhagic fever: results of a case control study
    Maria Aparecida A Figueiredo
    State University of Bahia, Salvador, Brazil
    PLoS Negl Trop Dis 4:e699. 2010
    The physiopathology of dengue hemorrhagic fever (DHF), a severe form of Dengue Fever, is poorly understood...
  49. ncbi Epidemic dengue and dengue hemorrhagic fever at the Texas-Mexico border: results of a household-based seroepidemiologic survey, December 2005
    Mary M Ramos
    Dengue Branch, Division of Vector Borne Infectious Disease, Centers for Disease Control and Prevention, San Juan, Puerto Rico
    Am J Trop Med Hyg 78:364-9. 2008
    A dengue-2 epidemic causing dengue hemorrhagic fever (DHF) occurred in the contiguous border cities of Matamoros, Tamaulipas (Mexico), and Brownsville, TX, in 2005...
  50. ncbi A clinical study of the patients with dengue hemorrhagic fever during the epidemic of 1996 at Lucknow, India
    R Agarwal
    Department of Microbiology, KG Medical College, Lucknow, India
    Southeast Asian J Trop Med Public Health 30:735-40. 1999
    This paper describes the clinical findings in 206 patients with dengue fever (DF) or with dengue hemorrhagic fever (DHF) during the epidemic of 1996 at Lucknow...
  51. pmc Reemergence of dengue virus type-3 (subtype-III) in India: implications for increased incidence of DHF & DSS
    Paban Kumar Dash
    Division of Virology, Defence R and D Establishment, Jhansi Road, Gwalior 474002, MP, India
    Virol J 3:55. 2006
    ..We have carried out a detailed investigation of the 2004 outbreak by Serosurveillance, RT-PCR, nested PCR, virus isolation and genotyping. We also report the molecular epidemiological investigation of these outbreaks...
  52. ncbi Size and charge characteristics of the protein leak in dengue shock syndrome
    Bridget A Wills
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    J Infect Dis 190:810-8. 2004
    he mechanism underlying the transient vascular leak syndrome of dengue hemorrhagic fever (DHF) is unknown...
  53. ncbi Coagulation abnormalities in dengue hemorrhagic Fever: serial investigations in 167 Vietnamese children with Dengue shock syndrome
    Bridget A Wills
    Centre for Tropical Diseases and Wellcome Trust Clinical Research Unit, Cho Quan Hospital, Ho Chi Minh City, Vietnam
    Clin Infect Dis 35:277-85. 2002
    ..Rather than causing true disseminated intravascular coagulation, dengue infection may activate fibrinolysis primarily, degrading fibrinogen directly and prompting secondary activation of procoagulant homeostatic mechanisms...
  54. doi The benign nature of acute dengue infection in hospitalized older adults in Singapore
    D C Lye
    Department of Infectious Disease, Tan Tock Seng Hospital, Singapore
    Int J Infect Dis 14:e410-3. 2010
    ..In Singapore, dengue primarily affects adults. This study aimed to determine if older dengue patients in Singapore have greater morbidity and mortality...
  55. ncbi Antibodies from dengue patient sera cross-react with endothelial cells and induce damage
    Chiou Feng Lin
    Department of Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan, Republic of China
    J Med Virol 69:82-90. 2003
    ..causes a wide range of diseases from the mild febrile illness dengue fever to the life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS)...
  56. pmc Both virus and tumor necrosis factor alpha are critical for endothelium damage in a mouse model of dengue virus-induced hemorrhage
    Hsuen Chin Chen
    Graduate Institute of Immunology, National Taiwan University College of Medicine, No 1 Jen Ai Road, Section 1, Taipei 10051, Taiwan, Republic of China
    J Virol 81:5518-26. 2007
    ..This finding highlights the contribution of the innate immune response to dengue hemorrhage...
  57. ncbi Transmission of epidemic dengue hemorrhagic fever in easternmost Indonesia
    Nono C Sukri
    United States Naval Medical Research Unit No 2, Jakarta, Indonesia
    Am J Trop Med Hyg 68:529-35. 2003
    In April 2001, a second suspected outbreak of dengue hemorrhagic fever in the easternmost region of Indonesia was investigated in Merauke, a town located in the southeastern corner of Papua, by the Indonesian Ministry of Health and the U...
  58. pmc Serotype-specific differences in the risk of dengue hemorrhagic fever: an analysis of data collected in Bangkok, Thailand from 1994 to 2006
    Jessica R Fried
    Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Negl Trop Dis 4:e617. 2010
    ..It is unclear whether dengue serotypes differ in their propensity to cause severe disease. We analyzed differences in serotype-specific disease severity in children presenting for medical attention in Bangkok, Thailand...
  59. ncbi Clinical characteristics and risk factors for concurrent bacteremia in adults with dengue hemorrhagic fever
    Ing Kit Lee
    Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Taiwan, Republic of China
    Am J Trop Med Hyg 72:221-6. 2005
    ..better understand the clinical characteristics of concurrent bacteremia (dual infection) in patients with dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) and identify predictive risk factors for dual infection, 100 patients ..
  60. ncbi Immunopathological mechanisms in dengue and dengue hemorrhagic fever
    Sharone Green
    University of Massachusetts Medical School, Center for Infectious Disease and Vaccine Research, Worcester, Massachusetts 01655, USA
    Curr Opin Infect Dis 19:429-36. 2006
    The continued emergence of dengue virus infection and its severe disease manifestation, dengue hemorrhagic fever, is a growing public health problem...
  61. ncbi T cell responses in dengue hemorrhagic fever: are cross-reactive T cells suboptimal?
    Juthathip Mongkolsapaya
    Department of Immunology, Division of Medicine, Hammersmith Hospital, Imperial College, Du Cane Road, London W12 0NN, United Kingdom
    J Immunol 176:3821-9. 2006
    ..Cross-reactive Dengue-specific T cells seem to show suboptimal degranulation but high cytokine production, which may contribute to the development of the vascular leak characteristic of Dengue hemorrhagic fever.
  62. ncbi Role of T cells, cytokines and antibody in dengue fever and dengue haemorrhagic fever
    Joshua Fink
    Novartis Institute for Tropical Diseases, 10 Biopolis Road, 05 01 Chromos, Singapore
    Rev Med Virol 16:263-75. 2006
    ..The need for effective measures against dengue and dengue-related illness is clear. We propose that drugs against dengue virus, or the symptoms of severe dengue disease, are a viable goal...
  63. pmc Age and clinical dengue illness
    Joseph R Egger
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    Emerg Infect Dis 13:924-5. 2007
    ..We use data from clinical patients to show that the relative risk of having classical disease after primary dengue virus infection increases with age. This relationship has implications for strategies aimed at controlling dengue fever...
  64. ncbi TNF-alpha-308A allele, a possible severity risk factor of hemorrhagic manifestation in dengue fever patients
    M T Fernandez-Mestre
    Laboratorio de Fisiopatologia, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
    Tissue Antigens 64:469-72. 2004
    ..This finding supports studies reporting a possible association between elevated levels of circulating TNF, vascular permeability, and hemorrhage in patients with dengue hemorrhagic fever.
  65. ncbi Burden of symptomatic dengue infection in children at primary school in Thailand: a prospective study
    Katie B Anderson
    Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    Lancet 369:1452-9. 2007
    ..Dengue viruses are a major cause of morbidity and mortality in tropical and subtropical areas. Our aim was to assess prospectively the burden of dengue-related illness in children in Thailand...
  66. ncbi Dengue and dengue hemorrhagic fever: management issues in an intensive care unit
    Sunit Singhi
    The Department of Pediatrics, Advanced Pediatrics Centre, Postrgraduate Institute of Medical Education and Research, Chandigarh, India
    J Pediatr (Rio J) 83:S22-35. 2007
    ..To describe the epidemiology, clinical features and treatment of dengue fever and dengue shock syndrome...
  67. pmc Cross-reactive T-cell responses to the nonstructural regions of dengue viruses among dengue fever and dengue hemorrhagic fever patients in Malaysia
    Ramapraba Appanna
    Department of Medical Microbiology, Faculty of Medicine, University Malaya, 50603, Kuala Lumpur, Malaysia
    Clin Vaccine Immunol 14:969-77. 2007
    ..enzyme-linked immunospot (ELISPOT) assay of samples from 13 selected patients with dengue fever (DF) and dengue hemorrhagic fever (DHF). NS3 and predominantly NS3(422-431) were found to be important T-cell targets...
  68. ncbi Characteristics of a dengue hemorrhagic fever outbreak in 2001 in Kaohsiung
    Ping Chang Lai
    Section of Infectious Diseases, Department of Medicine, Tian Sheng Memorial Hospital, Tong Kang, Pingtung, Taiwan, ROC
    J Microbiol Immunol Infect 37:266-70. 2004
    ..2%) were the most common presentations. A high proportion of patients were classified as having dengue hemorrhagic fever (DHF) [6/13; 46...
  69. ncbi Effect of increasing age on the trend of dengue and dengue hemorrhagic fever in Singapore
    Eng Eong Ooi
    Int J Infect Dis 7:231-2. 2003
  70. doi Alteration of cytokines and chemokines during febrile episodes associated with endothelial cell damage and plasma leakage in dengue hemorrhagic fever
    Punnee Butthep
    Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Pediatr Infect Dis J 31:e232-8. 2012
    ..The study was designed to demonstrate the alteration of cytokines and chemokines in dengue-infected patients during febrile episodes...
  71. pmc Detection of dengue-4 virus in pune, western india after an absence of 30 years--its association with two severe cases
    Dayaraj Cecilia
    National Institute of Virology, 20 A Dr Ambedkar Road, Pune 411001, Maharashtra, India
    Virol J 8:46. 2011
    ..Till the 1980 s, India and Sri Lanka reported low number of dengue hemorrhagic fever (DHF) cases despite circulation of all four serotypes of dengue virus (DENV)...
  72. ncbi Activation of coagulation and fibrinolysis during dengue virus infection
    Y H Huang
    Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC
    J Med Virol 63:247-51. 2001
    Dengue virus infection can induce mild dengue fever (DF) or severe dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS) in human. The pathogenesis of hemorrhage in dengue virus infection is not fully understood...
  73. pmc Antibodies play a greater role than immune cells in heterologous protection against secondary dengue virus infection in a mouse model
    Jennifer L Kyle
    Division of Infectious Diseases, School of Public Health, University of California, Berkeley, 1 Barker Hall 424, Berkeley, CA 94720 7354, USA
    Virology 380:296-303. 2008
    The four serotypes of dengue virus (DENV1-4) are causative agents of dengue fever and dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS)...
  74. ncbi Heavy proteinuria following dengue hemorrhagic fever
    Sakara Hutspardol
    Department of Pediatrics, Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand
    Southeast Asian J Trop Med Public Health 42:579-82. 2011
    ..7 mg/kg/day which developed following dengue hemorrhagic fever. Due to prolonged hypoalbuminemia from renal loss, right pleural effusion persisted and required ..
  75. ncbi Emergence and continued circulation of dengue-2 (genotype IV) virus strains in northern India
    Paban Kumar Dash
    Division of Virology, Defence Research and Development Establishment, Gwalior, MP, India
    J Med Virol 74:314-22. 2004
    ....
  76. doi The use of two-dimension electrophoresis to identify serum biomarkers from patients with dengue haemorrhagic fever
    Ravindran Thayan
    Department of Medical Microbiology, Faculty of Medicine, University Malaya, 50603, Kuala Lumpur, Malaysia
    Trans R Soc Trop Med Hyg 103:413-9. 2009
    ..Our study suggests that alpha1-antitrypsin and NS1 protein could be used as biomarkers as early indicators of DHF risk among patients with suspected dengue infection...
  77. ncbi Dengue hemorrhagic fever patients with acute abdomen: clinical experience of 14 cases
    Boon Siang Khor
    Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan, Republic of China
    Am J Trop Med Hyg 74:901-4. 2006
    Among 328 patients with dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), 14 (4 men and 10 women, median age 44 years) had acute abdomen. DHF/DSS was initially suspected in only 2 of these 14 patients...
  78. ncbi Vascular endothelium: the battlefield of dengue viruses
    Atanu Basu
    National Institute of Virology, Pune, India
    FEMS Immunol Med Microbiol 53:287-99. 2008
    ..The present review provides a broad overview of the effects of DV infection and the associated host responses contributing towards alterations in vascular endothelial cell physiology and damage that may be responsible for the DHF/DSS...
  79. doi Phenotypic and genotypic characterization of dengue virus isolates differentiates dengue fever and dengue hemorrhagic fever from dengue shock syndrome
    Anne Tuiskunen
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Arch Virol 156:2023-32. 2011
    ..cause 50-100 million cases of acute febrile disease every year, including 500,000 reported cases of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS)...
  80. pmc Dengue hemorrhagic fever is associated with polymorphisms in JAK1
    Luciano K Silva
    Fundacao Oswaldo Cruz, Centro de Pesquisas Goncalo Moniz, Laboratory of Pathology and Molecular Biology, Rua Waldemar Falcão, Candeal, Salvador, Bahia, Brazil
    Eur J Hum Genet 18:1221-7. 2010
    To identify genes associated with the clinical presentation of dengue, 50 cases of probable or possible dengue hemorrhagic fever (DHF), 236 dengue fever (DF), and 236 asymptomatic infections were genotyped for 593 single-nucleotide ..
  81. doi A re-evaluation of the mechanisms leading to dengue hemorrhagic fever
    Sansanee Noisakran
    Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Ann N Y Acad Sci 1171:E24-35. 2009
    ..in a spectrum of clinical symptoms, ranging from undifferentiated flu-like illness, mild dengue fever, to dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS), a life-threatening illness...
  82. doi Dengue hemorrhage in a mouse model
    Betty A Wu-Hsieh
    National Taiwan University, College of Medicine, Graduate Institute of Immunology, Taipei, Taiwan
    Ann N Y Acad Sci 1171:E42-7. 2009
    ..Our mouse model offers the opportunity to test potential dengue vaccines and therapeutics to treat dengue hemorrhage and to test hemorrhage induction potentials of dengue viral strains...
  83. ncbi Correlation of disease spectrum among four Dengue serotypes: a five years hospital based study from India
    Rajni Kumaria
    Singapore MIT Alliance for Research and Technology, National University of Singapore, Singapore
    Braz J Infect Dis 14:141-6. 2010
    The recognition of DF (DHF Dengue Hemorrhagic Fever) is very complicated due to occurrence of a wide spectrum of clinical signs and symptoms during acute phase of illness...
  84. ncbi Secondary dengue virus type 4 infections in Vietnam
    Philippe Buchy
    Institut Pasteur in Nha Trang, Nha Trang City, Vietnam
    Southeast Asian J Trop Med Public Health 36:178-85. 2005
    ..to describe clinical and biological features of patients with a suspected diagnosis of dengue fever/dengue hemorrhagic fever during an outbreak in Central Vietnam...
  85. ncbi The role of vascular endothelial growth factor leading to vascular leakage in children with dengue virus infection
    Patcharapa Sathupan
    Department of Paediatrics, Thammasat University, Patumthani, Thailand
    Ann Trop Paediatr 27:179-84. 2007
    ..Increased vascular permeability is the main aetiology for hypovolaemic shock and circulatory failure in dengue haemorrhagic fever (DHF)...
  86. ncbi Do escape mutants explain rapid increases in dengue case-fatality rates within epidemics?
    M G Guzman
    Institute of Tropical Medicine Pedro Kouri, Havana, Cuba
    Lancet 355:1902-3. 2000
    ..When inoculated into a new dengue-1-immune host, these viruses are free to interact with the more abundant infection-enhancing antibodies to produce severe disease...
  87. pmc A prospective nested case-control study of Dengue in infants: rethinking and refining the antibody-dependent enhancement dengue hemorrhagic fever model
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts, United States
    PLoS Med 6:e1000171. 2009
    b>Dengue hemorrhagic fever (DHF) is the severe and life-threatening syndrome that can develop after infection with any one of the four dengue virus (DENV) serotypes...
  88. pmc Dengue hemorrhagic fever: the sensitivity and specificity of the world health organization definition for identification of severe cases of dengue in Thailand, 1994-2005
    Anon Srikiatkhachorn
    University of Massachusetts Medical School, Worcester, MA 01655, USA
    Clin Infect Dis 50:1135-43. 2010
    ..usually classified according to the World Health Organization (WHO) guidelines into dengue fever (DF) and dengue hemorrhagic fever (DHF). The ability of these guidelines to categorize severe dengue illness has recently been questioned.
  89. pmc Dengue viral infections
    G N Malavige
    Department of Clinical Immunology, A Floor, West Block, Queens Medical Centre, University Hospital, Nottingham NG7 2UH, UK
    Postgrad Med J 80:588-601. 2004
    ..This review outlines aspects of the epidemiology of dengue infections, the dengue virus and its mosquito vector, clinical features and pathogenesis of dengue infections, and the management and control of these infections...
  90. ncbi Surveillance for an emerging disease: dengue hemorrhagic fever in Puerto Rico, 1988-1997. Puerto Rico Association of Epidemiologists
    J G Rigau-Perez
    Dengue Branch, Centers for Disease Control and Prevention, San Juan, Puerto Rico 00921 3200
    P R Health Sci J 18:337-45. 1999
    ..The dengue hemorrhagic fever (DHF) surveillance system in Puerto Rico collects patient data from three sources: dengue case ..
  91. doi Combination of CTLA-4 and TGFbeta1 gene polymorphisms associated with dengue hemorrhagic fever and virus load in a dengue-2 outbreak
    Rong Fu Chen
    Department of Medical Research, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University, Kaohsiung, Taiwan
    Clin Immunol 131:404-9. 2009
    The pathogenesis of dengue hemorrhagic fever (DHF) has been considered to be massive immune activation of T cells...
  92. ncbi Prospective study of the duration and magnitude of viraemia in children hospitalised during the 1996-1997 dengue-2 outbreak in French Polynesia
    B Murgue
    Unité de Recherche en Virologie, Institut Territorial de Recherches Medicales Louis Malarde, Papeete, Tahiti, French Polynesia
    J Med Virol 60:432-8. 2000
    ..7-5.6 Log(10) TCID(50)/ml. A significant difference was not observed in the magnitude and duration of viraemia in patients with primary versus secondary infections. The severity of the illness, however, was correlated with both criteria...
  93. ncbi Risk factors of dengue shock syndrome in children
    Taweewong Tantracheewathorn
    Department of Pediatrics, Bangkok Metropolitan Administration Medical College and Vajira Hospital, Dusit, Bangkok 10300, Thailand
    J Med Assoc Thai 90:272-7. 2007
    ..The morbidity and mortality from DSS can be decreased by early diagnosis of shock and adequate replacement of plasma loss. Therefore, determination of risk factors of DSS is crucial for early detection and proper management of shock...
  94. ncbi Understanding the contribution of cellular immunity to dengue disease pathogenesis
    Anuja Mathew
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Immunol Rev 225:300-13. 2008
    ..The strong association of severe dengue illness, dengue hemorrhagic fever (DHF), with heterologous secondary infection and high cytokine levels has led to a prevailing view that ..
  95. ncbi Risk factors and clinical features associated with severe dengue infection in adults and children during the 2001 epidemic in Chonburi, Thailand
    Ole Wichmann
    Institute of Tropical Medicine, Humboldt University, Berlin, Germany
    Trop Med Int Health 9:1022-9. 2004
    ..In recent years, there has been a progressive shift in age-distribution towards older children and adults. We investigated an outbreak in 2001 in both children and adults, in an endemic area of Thailand...
  96. ncbi Dengue hemorrhagic fever epidemiology in Thailand: description and forecasting of epidemics
    Philippe Barbazan
    Institut de Recherche pour le Developpement, IRD, 213 rue La Fayette, 75010 Paris, France
    Microbes Infect 4:699-705. 2002
    Despite the use of a variety of control strategies, dengue hemorrhagic fever (DHF) control is a major and permanent challenge for public health services in Thailand and in Southeast Asia...
  97. doi Dengue hemorrhagic fever outbreak in children in Port Sudan
    Amal Malik
    Department of Pediatric, Red Sea University, Port Sudan, Sudan
    J Infect Public Health 4:1-6. 2011
    Dengue fever (DF)/dengue hemorrhagic fever (DHF) has emerged as a global public health problem with countries in Asia and the Pacific sharing more than 70% of the disease burden...
  98. pmc Emergence and global spread of a dengue serotype 3, subtype III virus
    William B Messer
    University of North Carolina, Chapel Hill, North Carolina, USA
    Emerg Infect Dis 9:800-9. 2003
    Over the past two decades, dengue virus serotype 3 (DENV-3) has caused unexpected epidemics of dengue hemorrhagic fever (DHF) in Sri Lanka, East Africa, and Latin America...
  99. ncbi The future of dengue vaccines
    Scott B Halstead
    Department of Preventive Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    Lancet 360:1243-5. 2002
  100. doi Dengue and dengue hemorrhagic fever among adults: clinical outcomes related to viremia, serotypes, and antibody response
    Adriana O Guilarde
    Instituto de Patologia Tropical e Saude Publica, Universidade Federal de Goias, Brazil
    J Infect Dis 197:817-24. 2008
    ..In Brazil, the disease burden predominantly affects adults, with an increasing trend toward progression to dengue hemorrhagic fever (DHF) noted.
  101. ncbi Anti-dengue virus nonstructural protein 1 antibodies recognize protein disulfide isomerase on platelets and inhibit platelet aggregation
    Hsien Jen Cheng
    Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan, Taiwan
    Mol Immunol 47:398-406. 2009
    ..Furthermore, the cross-reactivity of dengue hemorrhagic fever patient sera with platelets was reduced when patient sera were preabsorbed with PDI or P311-330...

Research Grants75

  1. Validation of Src kinases as Anti-Dengue Viral Targets
    Priscilla Yang; Fiscal Year: 2009
    ..These small molecules can then be used to study how dengue virus interacts with its host and to develop therapies for the treatment of dengue virus infections. ..
  2. Inhibition of the Membrane Fusion Proteins of Flaviviruses and Alphaviruses
    Margaret Kielian; Fiscal Year: 2007
    ..are an estimated 50-100 million cases of dengue fever and 500,000 cases of the more lethal complication dengue hemorrhagic fever per year, with significant impact on both human health and the economies of developing countries...
  3. IMMUNOPATHOGENESIS OF HANTAVIRUS PULMONARY SYNDROME
    Francis Ennis; Fiscal Year: 1999
    ..of the capillary leak syndrome, hemoconcentration and thrombocytopenia which is observed in cases of dengue hemorrhagic fever (DHF)...
  4. Flavivirus Infections: Pathogenesis and Prevention
    Alan Rothman; Fiscal Year: 2009
    ..is still considerable, the principal challenge presented by dengue virus is its ability to cause dengue hemorrhagic fever (DHF), a potentially fatal plasma leakage syndrome...
  5. Flavivirus Infections: Pathogenesis and Prevention
    Alan L Rothman; Fiscal Year: 2010
    ..is still considerable, the principal challenge presented by dengue virus is its ability to cause dengue hemorrhagic fever (DHF), a potentially fatal plasma leakage syndrome...
  6. Computational Identification of Dengue Virus T-Cell Epitopes
    Vladimir Brusic; Fiscal Year: 2003
    ..extended to HLA class I epitopes and analysis of their role in the severe manifestation of the infection, dengue hemorrhagic fever. Dengue virus has a small genome (10...
  7. Mechanisms of sylvatic dengue emergence
    Scott C Weaver; Fiscal Year: 2010
    ..DENV infects 100 million people per year in over 100 countries, causing classical dengue fever as well as dengue hemorrhagic fever and dengue shock syndrome, while CHIKV has caused recent epidemics involving over 2 million persons with ..
  8. Mechanisms of sylvatic dengue emergence
    Scott Weaver; Fiscal Year: 2009
    ..DENV infects 100 million people per year in over 100 countries, causing classical dengue fever as well as dengue hemorrhagic fever and dengue shock syndrome, while CHIKV has caused recent epidemics involving over 2 million persons with ..
  9. Dengue Epitope Vaccine,Tetravalent & MHCII-Targeted
    J Thomas August; Fiscal Year: 2007
    ..both for their possible role in prevention of infection and proposed negative role in the etiology of dengue hemorrhagic fever. A human ex vivo T-cell activation assay will be used to analyze the biological correlates of the ..
  10. Dengue Epitope Vaccine,Tetravalent & MHCII-Targeted
    J August; Fiscal Year: 2004
    ..both for their possible role in prevention of infection and proposed negative role in the etiology of dengue hemorrhagic fever. A human ex vivo T-cell activation assay will be used to analyze the biological correlates of the ..
  11. FUNCTIONAL ANALYSIS OF DENGUE VIRUS ANTIGENS NS3 AND NS5
    Radhakrishnan Padmanabhan; Fiscal Year: 1993
    ..Apart from dengue fever, a more severe and fatal form of the disease occurs in children called dengue hemorrhagic fever, or the dengue shock syndrome...
  12. Dengue Epitope Vaccine,Tetravalent & MHCII-Targeted
    J August; Fiscal Year: 2005
    ..both for their possible role in prevention of infection and proposed negative role in the etiology of dengue hemorrhagic fever. A human ex vivo T-cell activation assay will be used to analyze the biological correlates of the ..
  13. Dengue Epitope Vaccine,Tetravalent & MHCII-Targeted
    J August; Fiscal Year: 2006
    ..both for their possible role in prevention of infection and proposed negative role in the etiology of dengue hemorrhagic fever. A human ex vivo T-cell activation assay will be used to analyze the biological correlates of the ..
  14. Dengue Epitope Vaccine,Tetravalent & MHCII-Targeted
    J August; Fiscal Year: 2003
    ..both for their possible role in prevention of infection and proposed negative role in the etiology of dengue hemorrhagic fever. A human ex vivo T-cell activation assay will be used to analyze the biological correlates of the ..
  15. A VEE Replicon-Based Vaccine for Dengue Virus
    Laura White; Fiscal Year: 2006
    ..emerging pathogens, infects humans causing a spectrum of clinical manifestations including dengue fever, dengue hemorrhagic fever and dengue shock syndrome...
  16. A VEE Replicon-Based Vaccine for Dengue Virus
    Laura White; Fiscal Year: 2005
    ..emerging pathogens, infects humans causing a spectrum of clinical manifestations including dengue fever, dengue hemorrhagic fever and dengue shock syndrome...
  17. FUNCTIONAL ANALYSIS OF DENGUE VIRUS ANTIGENS NS3 AND NS5
    Radhakrishnan Padmanabhan; Fiscal Year: 2003
    ..Of these, more than 250,000 cases involve life threatening dengue hemorrhagic fever / dengue shock syndrome...
  18. FUNCTIONAL ANALYSIS OF DENGUE VIRUS ANTIGENS NS3 AND NS5
    Radhakrishnan Padmanabhan; Fiscal Year: 2001
    ..Of these, more than 250,000 cases involve life threatening dengue hemorrhagic fever / dengue shock syndrome...
  19. FUNCTIONAL ANALYSIS OF DENGUE VIRUS ANTIGENS NS3 AND NS5
    Radhakrishnan Padmanabhan; Fiscal Year: 2002
    ..Of these, more than 250,000 cases involve life threatening dengue hemorrhagic fever / dengue shock syndrome...
  20. FUNCTIONAL ANALYSIS OF DENGUE VIRUS ANTIGENS NS3 AND NS5
    Radhakrishnan Padmanabhan; Fiscal Year: 2000
    ..Of these, more than 250,000 cases involve life threatening dengue hemorrhagic fever / dengue shock syndrome...
  21. Sustainable Control of Aedes aegypti and epidemic dengue
    Barry J Beaty; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Epidemic dengue fever and dengue hemorrhagic fever are major public health problems in the Americas...
  22. Inhibiting Cellular Autophagy to Thwart Dengue Virus Packaging and Replication
    Karla Kirkegaard; Fiscal Year: 2012
    ..infection severity ranges from the self-limiting Dengue fever to the more lethal forms of the disease, Dengue hemorrhagic fever and Dengue shock syndrome...
  23. Fitness and Virulence of Dengue Virus in the Context of Changing Host Immunity
    Eva Harris; Fiscal Year: 2010
    ..DENV infection results in dengue fever, an acute febrile illness, or the more severe, life- threatening dengue hemorrhagic fever/dengue shock syndrome...
  24. Fitness and Virulence of Dengue Virus in the Context of Changing Host Immunity
    Eva Harris; Fiscal Year: 2009
    ..DENV infection results in dengue fever, an acute febrile illness, or the more severe, life- threatening dengue hemorrhagic fever/dengue shock syndrome...
  25. Safe Antibody Prophylaxis and Therapy Against Dengue Virus
    Michael Diamond; Fiscal Year: 2009
    ..the four serotypes of DV cause an estimated 100 million new cases of dengue fever and 250,000 cases of dengue hemorrhagic fever (DHF) per year, primarily in tropical and subtropical areas...
  26. STRUCTURE BASED ANALYSIS OF DENGUE VIRUS SERINE PROTEASE
    Krishna Murthy; Fiscal Year: 2000
    ..Of these, more than 250,000 cases involve life-threatening dengue hemorrhagic fever/dengue shock syndrome with no effective chemotherapy or vaccine currently available...
  27. Safe Antibody Prophylaxis and Therapy Against Dengue Virus
    Michael S Diamond; Fiscal Year: 2010
    ..the four serotypes of DV cause an estimated 100 million new cases of dengue fever and 250,000 cases of dengue hemorrhagic fever (DHF) per year, primarily in tropical and subtropical areas...
  28. STRUCTURE BASED ANALYSIS OF DENGUE VIRUS SERINE PROTEASE
    Krishna Murthy; Fiscal Year: 2002
    ..Of these, more than 250,000 cases involve life-threatening dengue hemorrhagic fever/dengue shock syndrome with no effective chemotherapy or vaccine currently available...
  29. STRUCTURE BASED ANALYSIS OF DENGUE VIRUS SERINE PROTEASE
    Krishna Murthy; Fiscal Year: 2003
    ..Of these, more than 250,000 cases involve life-threatening dengue hemorrhagic fever/dengue shock syndrome with no effective chemotherapy or vaccine currently available...
  30. STRUCTURE BASED ANALYSIS OF DENGUE VIRUS SERINE PROTEASE
    Krishna Murthy; Fiscal Year: 2001
    ..Of these, more than 250,000 cases involve life-threatening dengue hemorrhagic fever/dengue shock syndrome with no effective chemotherapy or vaccine currently available...
  31. STRUCTURE BASED ANALYSIS OF DENGUE VIRUS SERINE PROTEASE
    Krishna Murthy; Fiscal Year: 2004
    ..Of these, more than 250,000 cases involve life-threatening dengue hemorrhagic fever/dengue shock syndrome with no effective chemotherapy or vaccine currently available...
  32. Analysis of clinical laboratory variables for early dengue illness classification
    James Potts; Fiscal Year: 2009
    ..dengue can manifest a more severe illness with bleeding tendency, thrombocytopenia, and plasma leakage (dengue hemorrhagic fever, DHF)...
  33. Roles of secreted NS1 and NS1 antibody in dengue virus infection and immunity
    Eva Harris; Fiscal Year: 2009
    ..DV) infection causes a spectrum of disease ranging from self-limited Dengue Fever to lifethreatening Dengue Hemorrhagic Fever/Dengue Shock Syndrome...
  34. Flavivirus Infections: Pathogenesis and Prevention
    Francis Ennis; Fiscal Year: 2003
    The major goal of this Program Project is to understand the immunopathology of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), the severe complications of dengue virus infections...
  35. Flavivirus Infections: Pathogenesis and Prevention
    Francis Ennis; Fiscal Year: 2007
    The major goal of this Program Project is to understand the immunopathology of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), the severe complications of dengue virus infections...
  36. Flavivirus Infections: Pathogenesis and Prevention
    Francis Ennis; Fiscal Year: 2004
    The major goal of this Program Project is to understand the immunopathology of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), the severe complications of dengue virus infections...
  37. Flavivirus Infections: Pathogenesis and Prevention
    Francis Ennis; Fiscal Year: 2006
    The major goal of this Program Project is to understand the immunopathology of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), the severe complications of dengue virus infections...
  38. Flavivirus Infections: Pathogenesis and Prevention
    Francis Ennis; Fiscal Year: 2005
    The major goal of this Program Project is to understand the immunopathology of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), the severe complications of dengue virus infections...
  39. Validation of Src kinases as Anti-Dengue Viral Targets
    PRISCILLA LI NING YANG; Fiscal Year: 2010
    ..These small molecules can then be used to study how dengue virus interacts with its host and to develop therapies for the treatment of dengue virus infections. ..
  40. Validation of Src kinases as Anti-Dengue Viral Targets
    PRISCILLA LI NING YANG; Fiscal Year: 2010
    ..These small molecules can then be used to study how dengue virus interacts with its host and to develop therapies for the treatment of dengue virus infections. ..
  41. Determinants of protection and enhancement of dengue infection/disease in vivo
    Eva Harris; Fiscal Year: 2010
    ..DENV infection results in dengue fever, an acute febrile illness, or the more severe, life- threatening dengue hemorrhagic fever/dengue shock syndrome...
  42. Anti-Flavivirus Immunotherapeutics
    EILEEN NAKANO; Fiscal Year: 2001
    ..There are 100 million cases of dengue infection each year with 250,000 cases of the life-threatening Dengue Hemorrhagic Fever/Dengue Shock Syndrome (DHS/DSS). Treatment options are limited to symptoms management...
  43. Dengue vaccine and viral evolution in rural Thailand
    Timothy Endy; Fiscal Year: 2009
    ..200 years as four distinct serotypes and an important human pathogen producing severe illness known as dengue hemorrhagic fever (DHF). Dengue is considered an emerged global public health problem...
  44. Dengue vaccine and viral evolution in rural Thailand
    TIMOTHY PAUL ENDY; Fiscal Year: 2010
    ..200 years as four distinct serotypes and an important human pathogen producing severe illness known as dengue hemorrhagic fever (DHF). Dengue is considered an emerged global public health problem...
  45. Dissection of the mosquito Aedes Aegypti's immune responses to Dengue infection.
    Jose Ramirez; Fiscal Year: 2009
    ..5 million people at risk of contracting dengue fever and dengue hemorrhagic fever. We have already made a leap in the past year towards the understanding on how the mosquito's innate ..
  46. A CPE-Based HTS Assay for Antiviral Drug Screening Against Dengue Virus
    Qianjun Li; Fiscal Year: 2010
    ..In the Americas as of December 14, 2009, there were 893,453 reported cases, including 23,980 Dengue hemorrhagic fever (DHF) cases and 370 deaths...
  47. Dissection of the mosquito Aedes Aegypti's immune responses to Dengue infection.
    Jose Luis Ramirez; Fiscal Year: 2010
    ..5 million people at risk of contracting dengue fever and dengue hemorrhagic fever. We have already made a leap in the past year towards the understanding on how the mosquito's innate ..
  48. RNA-Protein Interactions in Flavivirus Infection
    MARIANO GARCIA BLANCO; Fiscal Year: 2007
    ..A conservative estimate of the population at risk is a staggering 2.5 billion people. DF can progress to dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), which are dreaded developments...
  49. Antibody-Based Protection Against Dengue Virus
    Michael Diamond; Fiscal Year: 2007
    ..the four serotypes of DENV cause an estimated 100 million new cases of dengue fever and 250,000 cases of dengue hemorrhagic fever (DHF) per year...
  50. Antibody-Based Protection Against Dengue Virus
    Michael S Diamond; Fiscal Year: 2010
    ..the four serotypes of DENV cause an estimated 100 million new cases of dengue fever and 250,000 cases of dengue hemorrhagic fever (DHF) per year...
  51. Rapid antigen detection test for Dengue infection
    Raymond Houghton; Fiscal Year: 2007
    ..million new case of Dengue infection per year, up to half a million of which progress to life-threatening Dengue Hemorrhagic Fever. Dengue is classified by NIAID as a re-emerging pathogen and a Category A biodefense agent...
  52. The role of antigen-presenting cells in dengue immunopathogenesis
    SIMON BARRATT BOYES; Fiscal Year: 2009
    ..range of clinical severities from self-limiting dengue fever (DF) to the more severe and life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). The pathogenesis of DHF and DSS is poorly understood...
  53. CONTROL OF URBAN CONTAINER BREEDING ARBROVIRUS VECTORS
    Dawn Wesson; Fiscal Year: 2007
    Emerging viral diseases, such as dengue hemorrhagic fever and West Nile viral encephalitis, pose a significant threat to public health...
  54. CONTROL OF URBAN CONTAINER BREEDING ARBROVIRUS VECTORS
    Dawn Wesson; Fiscal Year: 2006
    Emerging viral diseases, such as dengue hemorrhagic fever and West Nile viral encephalitis, pose a significant threat to public health...
  55. CONTROL OF URBAN CONTAINER BREEDING ARBROVIRUS VECTORS
    Dawn Wesson; Fiscal Year: 2003
    Emerging viral diseases, such as dengue hemorrhagic fever and West Nile viral encephalitis, pose a significant threat to public health...
  56. CONTROL OF URBAN CONTAINER BREEDING ARBROVIRUS VECTORS
    Dawn Wesson; Fiscal Year: 2005
    Emerging viral diseases, such as dengue hemorrhagic fever and West Nile viral encephalitis, pose a significant threat to public health...
  57. CONTROL OF URBAN CONTAINER BREEDING ARBROVIRUS VECTORS
    Dawn Wesson; Fiscal Year: 2004
    Emerging viral diseases, such as dengue hemorrhagic fever and West Nile viral encephalitis, pose a significant threat to public health...
  58. Latin America Workshop On Denge
    Jorge Osorio; Fiscal Year: 2009
    ..DENV causes classic Dengue ("break-bone") fever (DF), and more severe and sometimes fatal dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS)...
  59. INTERFERENCE TO DENGUE VIRUS REPLICATION IN MOSQUITOES
    Carol Blair; Fiscal Year: 2002
    ..About 50-100 million cases of dengue fever (DF) and >100,000 cases of life-threatening dengue hemorrhagic fever (DHF) occur annually worldwide...
  60. INTERFERENCE TO DENGUE VIRUS REPLICATION IN MOSQUITOES
    Carol Blair; Fiscal Year: 2003
    ..About 50-100 million cases of dengue fever (DF) and >100,000 cases of life-threatening dengue hemorrhagic fever (DHF) occur annually worldwide...
  61. INTERFERENCE TO DENGUE VIRUS REPLICATION IN MOSQUITOES
    Carol Blair; Fiscal Year: 2004
    ..About 50-100 million cases of dengue fever (DF) and >100,000 cases of life-threatening dengue hemorrhagic fever (DHF) occur annually worldwide...
  62. INTERFERENCE TO DENGUE VIRUS REPLICATION IN MOSQUITOES
    Carol Blair; Fiscal Year: 2006
    ..About 50-100 million cases of dengue fever (DF) and >100,000 cases of life-threatening dengue hemorrhagic fever (DHF) occur annually worldwide...
  63. INTERFERENCE TO DENGUE VIRUS REPLICATION IN MOSQUITOES
    Carol Blair; Fiscal Year: 2005
    ..About 50-100 million cases of dengue fever (DF) and >100,000 cases of life-threatening dengue hemorrhagic fever (DHF) occur annually worldwide...
  64. Antibody-Based Protection Against Dengue Virus
    Michael Diamond; Fiscal Year: 2009
    ..the four serotypes of DENV cause an estimated 100 million new cases of dengue fever and 250,000 cases of dengue hemorrhagic fever (DHF) per year...
  65. Dengue Epitope. Tetravalent. MHC II Targeted DNA Vaccine
    J August; Fiscal Year: 2003
    ..hot-spot sequences will also be tested ex vivo for their possible anti-viral role or correlation with dengue hemorrhagic fever. The vaccine formulation will exclude unnecessary or deleterious dengue sequences, particularly those MHC ..
  66. Risk Factors for Dengue Hemorrhagic Fever in Sri Lanka
    Aravinda de Silva; Fiscal Year: 2006
    ..Despite the fact that dengue hemorrhagic fever (DHF) has emerged to be a major problem in the Indian subcontinent, the disease and viruses circulating ..
  67. Risk Factors for Dengue Hemorrhagic Fever in Sri Lanka
    Aravinda de Silva; Fiscal Year: 2007
    ..Despite the fact that dengue hemorrhagic fever (DHF) has emerged to be a major problem in the Indian subcontinent, the disease and viruses circulating ..
  68. Novel small molecule inhibitors of dengue replication
    Dennis Hruby; Fiscal Year: 2009
    ..worldwide with dengue every year, including 500,000 cases of the more severe form of the disease, dengue hemorrhagic fever (DHF) and there are no approved vaccines or antiviral drugs available...
  69. PULSED ELECTRIC FIELD DELIVERED DENGUE VACCINE
    Alan King; Fiscal Year: 2000
    ..During this time, the Americas have seen the emergence of the most severe form of dengue, dengue hemorrhagic fever. In endemic areas, such as Southeast Asia, it is a disease of children and is a common cause of morbidity ..
  70. MICROCHIP-BASED FIELD ASSAY TO DETECT DENGUE VIRUS
    RICHARD MONTAGNA; Fiscal Year: 2000
    Dengue virus is the etiological agent responsible for Dengue Fever (DF), Dengue Hemorrhagic Fever (DHF), and Dengue Shock Syndrome (DSS)...
  71. Clinical Studies on the Mechanisms of DF/DHF
    Francis Ennis; Fiscal Year: 2003
    b>Dengue hemorrhagic fever (DHF) is a severe manifestation of mosquito-borne dengue virus (DV) infection that is characterized by plasma leakage...
  72. Molecular Immunopathogenesis of DHF/DSS
    Alan Rothman; Fiscal Year: 2003
    b>Dengue hemorrhagic fever (DHF) is the most common serious arboviral infection in the world, and is an emerging flavivirus infection, as is West Nile virus...
  73. MOLECULAR EPIDEMIOLOGY OF DENGUE IN PEURTO RICO
    W McMillan; Fiscal Year: 2000
    ..from Application): In the last twenty years, dengue fever (DF) and its more severe manifestations, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), have emerged as a global health problem...
  74. Dengue Reporter Virus Neutralization Assay for Clinical Studies
    Eva Harris; Fiscal Year: 2007
    ..resulting in an estimated 50 million cases of dengue fever and over 450,000 cases of life-threatening dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) each year...
  75. Dengue Reporter Virus Neutralization Assay for Clinical Studies
    Eva Harris; Fiscal Year: 2009
    ..resulting in an estimated 50 million cases of dengue fever and over 450,000 cases of life-threatening dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) each year...