virus diseases


Summary: A general term for diseases produced by viruses.

Top Publications

  1. pmc Interferon-inducible antiviral effectors
    Anthony J Sadler
    Monash Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia
    Nat Rev Immunol 8:559-68. 2008
  2. ncbi Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    L Alexopoulou
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, 06520, USA
    Nature 413:732-8. 2001
  3. ncbi Restoring function in exhausted CD8 T cells during chronic viral infection
    Daniel L Barber
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nature 439:682-7. 2006
  4. ncbi Functional role of type I and type II interferons in antiviral defense
    U Muller
    Institute of Molecular Biology I, University of Zurich, Switzerland
    Science 264:1918-21. 1994
  5. ncbi IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex
    Sergei V Kotenko
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Nat Immunol 4:69-77. 2003
  6. ncbi Molecular signature of CD8+ T cell exhaustion during chronic viral infection
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road Room G211, Atlanta, GA 30322, USA
    Immunity 27:670-84. 2007
  7. ncbi IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway
    Katherine A Fitzgerald
    Division of Infectious Disease and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Nat Immunol 4:491-6. 2003
  8. ncbi IRF-7 is the master regulator of type-I interferon-dependent immune responses
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 434:772-7. 2005
  9. ncbi Redefining chronic viral infection
    Herbert W Virgin
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell 138:30-50. 2009
  10. ncbi Functional classification of interferon-stimulated genes identified using microarrays
    M J de Veer
    Department of Cancer Biology, Lerner Research Institute, Cleveland, Ohio, USA
    J Leukoc Biol 69:912-20. 2001

Detail Information

Publications303 found, 100 shown here

  1. pmc Interferon-inducible antiviral effectors
    Anthony J Sadler
    Monash Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia
    Nat Rev Immunol 8:559-68. 2008
    ..Ongoing research continues to expose additional activities for these effector proteins and has revealed unanticipated functions of the antiviral response...
  2. ncbi Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    L Alexopoulou
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, 06520, USA
    Nature 413:732-8. 2001
    ..Moreover, poly(I:C) can induce activation of NF-kappaB and mitogen-activated protein (MAP) kinases independently of MyD88, and cause dendritic cells to mature...
  3. ncbi Restoring function in exhausted CD8 T cells during chronic viral infection
    Daniel L Barber
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nature 439:682-7. 2006
    ..These studies identify a specific mechanism of T-cell exhaustion and define a potentially effective immunological strategy for the treatment of chronic viral infections...
  4. ncbi Functional role of type I and type II interferons in antiviral defense
    U Muller
    Institute of Molecular Biology I, University of Zurich, Switzerland
    Science 264:1918-21. 1994
    ..Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant...
  5. ncbi IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex
    Sergei V Kotenko
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Nat Immunol 4:69-77. 2003
    ..This receptor-ligand system may contribute to antiviral or other defenses by a mechanism similar to, but independent of, type I IFNs...
  6. ncbi Molecular signature of CD8+ T cell exhaustion during chronic viral infection
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road Room G211, Atlanta, GA 30322, USA
    Immunity 27:670-84. 2007
    ..Thus, functional exhaustion is probably due to both active suppression and passive defects in signaling and metabolism. These results provide a framework for designing rational immunotherapies during chronic infections...
  7. ncbi IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway
    Katherine A Fitzgerald
    Division of Infectious Disease and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Nat Immunol 4:491-6. 2003
    ..Thus, IKKepsilon and TBK1 have a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response...
  8. ncbi IRF-7 is the master regulator of type-I interferon-dependent immune responses
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 434:772-7. 2005
    ..Thus, all elements of IFN responses, whether the systemic production of IFN in innate immunity or the local action of IFN from plasmacytoid dendritic cells in adaptive immunity, are under the control of IRF-7...
  9. ncbi Redefining chronic viral infection
    Herbert W Virgin
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell 138:30-50. 2009
  10. ncbi Functional classification of interferon-stimulated genes identified using microarrays
    M J de Veer
    Department of Cancer Biology, Lerner Research Institute, Cleveland, Ohio, USA
    J Leukoc Biol 69:912-20. 2001
  11. ncbi Modelling viral and immune system dynamics
    Alan S Perelson
    Theoretical Division, Los Alamos National Laboratory, New Mexico 87545, USA
    Nat Rev Immunol 2:28-36. 2002
    ..Mathematical modelling is also improving our understanding of T-cell dynamics and the quantitative events that underlie the immune response to pathogens...
  12. ncbi The dynamic life of natural killer cells
    Wayne M Yokoyama
    Howard Hughes Medical Institute, Rheumatology Division, Department of Medicine, Department of Pathology and Immunology, St Louis, Missouri 63110, USA
    Annu Rev Immunol 22:405-29. 2004
  13. ncbi Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma
    Merci M H Kusel
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, West Perth, Australia
    J Allergy Clin Immunol 119:1105-10. 2007
    ..Severe lower respiratory infections (LRIs) and atopic sensitization have been identified as independent risk factors for asthma...
  14. pmc Phylodynamics of infectious disease epidemics
    Erik M Volz
    Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genetics 183:1421-30. 2009
    ..While our model accurately estimates prevalence during exponential growth, we find that periods of decline are harder to identify...
  15. ncbi T cell exhaustion
    E John Wherry
    Department of Microbiology, Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Nat Immunol 12:492-9. 2011
  16. ncbi A weak signal for strong responses: interferon-alpha/beta revisited
    T Taniguchi
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nat Rev Mol Cell Biol 2:378-86. 2001
    ..What is the purpose of the constitutive weak interferon-alpha/beta signal?..
  17. ncbi Emerging virus diseases transmitted by whiteflies
    Jesús Navas-Castillo
    Instituto de Hortofruticultura Subtropical y Mediterránea La Mayora IHSM UMA CSIC, Consejo Superior de Investigaciones Cientificas, 29750 Algarrobo Costa, Malaga, Spain
    Annu Rev Phytopathol 49:219-48. 2011
    b>Virus diseases that have emerged in the past two decades limit the production of important vegetable crops in tropical, subtropical, and temperate regions worldwide, and many of the causal viruses are transmitted by whiteflies (order ..
  18. pmc Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children
    C S Murray
    Academic Division of Medicine and Surgery South, The University of Manchester, North West Lung Centre, South Manchester University Hospitals NHS Trust, Manchester M23 9LT, UK
    Thorax 61:376-82. 2006
    ..A study was undertaken to investigate the importance of allergen exposure in sensitised individuals in combination with viral infections and other potentially modifiable risk factors precipitating asthma hospital admission in children...
  19. pmc Role of viral respiratory infections in asthma and asthma exacerbations
    William W Busse
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Lancet 376:826-34. 2010
  20. pmc Mitochondrial antiviral signaling protein plays a major role in induction of the fish innate immune response against RNA and DNA viruses
    Stephane Biacchesi
    INRA, CRJ, Jouy en Josas, France
    J Virol 83:7815-27. 2009
    ..This report provides the first demonstration that teleost fish possess a functional RLR pathway in which MAVS may play a central role in the induction of the innate immune response...
  21. ncbi Type I interferons in host defense
    Daniel B Stetson
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 25:373-81. 2006
    ..These advances highlight the context-specific actions of type I IFNs and clarify the multiple points at which they are integrated into both innate and adaptive immunity...
  22. pmc Detection of respiratory viruses by molecular methods
    James B Mahony
    Regional Virology Laboratory, St Joseph s Healthcare Hamilton, Hamilton, Ontario, Canada
    Clin Microbiol Rev 21:716-47. 2008
  23. pmc VirHostNet: a knowledge base for the management and the analysis of proteome-wide virus-host interaction networks
    Vincent Navratil
    Universite de Lyon, INRA, UMR754, Ecole Nationale Veterinaire de Lyon, INSERM, U851, 21 Avenue Tony Garnier, Lyon, F 69007, France
    Nucleic Acids Res 37:D661-8. 2009
    ..Public access to the VirHostNet knowledge-based system is available at
  24. ncbi Comparison of nasopharyngeal flocked swabs and aspirates for rapid diagnosis of respiratory viruses in children
    K H Chan
    Department of Microbiology, The University of Hong Kong and Queen Mary Hospital, Hong Kong SAR, China
    J Clin Virol 42:65-9. 2008
    ..The quality of clinical specimens is a crucial determinant for virological diagnosis...
  25. ncbi Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease?
    J Weiler
    Novartis Institutes for BioMedical Research, Genome and Proteome Sciences, Basel, Switzerland
    Gene Ther 13:496-502. 2006
    ..Approaches to interfere with miRNA function in vitro and in vivo based on synthetic anti-miRNA oligonucleotides (AMOs) are discussed in this review...
  26. ncbi The Xs and Y of immune responses to viral vaccines
    Sabra L Klein
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Lancet Infect Dis 10:338-49. 2010
  27. pmc Evolutionarily conserved function of a viral microRNA
    G J Seo
    Molecular Genetics and Microbiology, The University of Texas at Austin, 1 University Station A5000, Austin, TX 78712 0162, USA
    J Virol 82:9823-8. 2008
    ..Furthermore, we show that these miRNAs are expressed in individuals diagnosed with polyomavirus-associated disease, suggesting their potential as targets for therapeutic intervention...
  28. pmc RNAi therapeutics: principles, prospects and challenges
    Lars Aagaard
    Division of Molecular Biology, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA
    Adv Drug Deliv Rev 59:75-86. 2007
    ..It is anticipated that RNAi will be a major therapeutic modality within the next several years, and clearly warrants intense investigation to fully understand the mechanisms involved...
  29. ncbi Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity
    Mitsutoshi Yoneyama
    Antiviral Innate Immunity Project, Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, Honkomagome, Tokyo, Japan
    J Immunol 175:2851-8. 2005
    ..These results highlight ingenious mechanisms for initiating antiviral innate immune responses and the action of virus-encoded inhibitors...
  30. pmc Comparison of nasopharyngeal and oropharyngeal swabs for the diagnosis of eight respiratory viruses by real-time reverse transcription-PCR assays
    Curi Kim
    U S Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 6:e21610. 2011
    ..Many acute respiratory illness surveillance systems collect and test nasopharyngeal (NP) and/or oropharyngeal (OP) swab specimens, yet there are few studies assessing the relative measures of performance for NP versus OP specimens...
  31. pmc Etiology of acute, non-malaria, febrile illnesses in Jayapura, northeastern Papua, Indonesia
    Narain H Punjabi
    U S Naval Medical Research Unit No 2, Jakarta, Indonesia
    Am J Trop Med Hyg 86:46-51. 2012
    ..There were 17 deaths, 7 (46.7%) were caused by meningitis/encephalitis. Multiple positive serologic results and few confirmed diagnoses indicate the need for improved diagnostics...
  32. pmc Swabbing for respiratory viral infections in older patients: a comparison of rayon and nylon flocked swabs
    S S Hernes
    Department of Geriatrics and Internal Medicine, Sorlandet Hospital Arendal HF, Serviceboks 605, 4809, Arendal, Norway
    Eur J Clin Microbiol Infect Dis 30:159-65. 2011
    ..4-67.4, p < 0.001). When swabbing for respiratory viruses in elderly patients, nasopharyngeal rather than oropharyngeal samples should be obtained. Nylon flocked swabs appear to be more efficient than rayon swabs...
  33. ncbi Molecular monitoring of causative viruses in child acute respiratory infection in endemo-epidemic situations in Shanghai
    Wei Wang
    Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Unit of Emerging Viruses, Shanghai, PR China
    J Clin Virol 49:211-8. 2010
    ..Numerous viruses are responsible for respiratory infections; however, both their distribution and genetic diversity, in a limited area and a population subgroup, have been studied only rarely during a sustained period of time...
  34. ncbi Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity
    Otto Haller
    Department of Virology, Institute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    J Interferon Cytokine Res 31:79-87. 2011
    ..Thus, MxA may form oligomeric rings around tubular nucleocapsid structures, thereby inhibiting their transcriptional and replicative function. Here we briefly review the most salient features of MxA expression and antiviral function...
  35. ncbi Viruses and interferons
    G C Sen
    Department of Molecular Biology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Annu Rev Microbiol 55:255-81. 2001
    ..Thus, in nature interferons and viruses maintain an equilibrium that allows regulated viral replication...
  36. pmc Real-time quantitative PCR assays for detection and monitoring of pathogenic human viruses in immunosuppressed pediatric patients
    F Watzinger
    Division of Molecular Microbiology and Development of Genetic Diagnostics, Children s Cancer Research Institute, Vienna, Austria
    J Clin Microbiol 42:5189-98. 2004
  37. pmc Immune pathways for translating viral infection into chronic airway disease
    Michael J Holtzman
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Adv Immunol 102:245-76. 2009
    ..Together, the findings identify an adaptive immune response that mediates acute disease and an innate immune response that drives chronic inflammatory lung disease in experimental and clinical settings...
  38. pmc Viral and cellular microRNAs as determinants of viral pathogenesis and immunity
    Eva Gottwein
    Department of Molecular Genetics and Microbiology and Center for Virology, Duke University Medical Center, Durham, NC 27710, USA
    Cell Host Microbe 3:375-87. 2008
    ..Here, we discuss what is known about how viral and cellular miRNAs influence viral replication and pathogenic potential through their regulation of viral mRNAs or by reshaping cellular gene expression...
  39. ncbi Does Toll-like receptor 3 play a biological role in virus infections?
    Kurt H Edelmann
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Virology 322:231-8. 2004
  40. ncbi Suspected chronic myocarditis at cardiac MR: diagnostic accuracy and association with immunohistologically detected inflammation and viral persistence
    Matthias Gutberlet
    Department of Diagnostic and Interventional Radiology and Nuclear Medicine, Charite, Campus Virchow Klinikum, Berlin, Germany
    Radiology 246:401-9. 2008
  41. ncbi Avoiding the void: cell-to-cell spread of human viruses
    Quentin Sattentau
    The Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Rev Microbiol 6:815-26. 2008
    ..This Review discusses the various mechanisms by which viruses move directly between cells and the implications of this for viral dissemination and pathogenesis...
  42. ncbi IRF family of transcription factors as regulators of host defense
    T Taniguchi
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Annu Rev Immunol 19:623-55. 2001
    ..Their functional roles, through interactions with their own or other members of the family of transcription factors, are becoming clearer in the regulation of host defense, such as innate and adaptive immune responses and oncogenesis...
  43. ncbi Viruses and interferon: a fight for supremacy
    Michael G Katze
    Department of Microbiology, University of Washington, Seattle, Washington 98195 8070, USA
    Nat Rev Immunol 2:675-87. 2002
    ..This effort must take advantage of the recent developments in functional genomics, bioinformatics and other emerging technologies...
  44. pmc Viruses and bacteria in the etiology of the common cold
    M J Mäkelä
    Department of Pediatrics, University of Turku, Finland
    J Clin Microbiol 36:539-42. 1998
    ..Bacterial infections were rare, supporting the concept that the common cold is almost exclusively a viral disease...
  45. pmc Nasal swab versus nasopharyngeal aspirate for isolation of respiratory viruses
    Terho Heikkinen
    Department of Pediatrics, Turku University Hospital Department of Virology, University of Turku, Turku, Finland
    J Clin Microbiol 40:4337-9. 2002
    ..The sensitivity of nasal swabs was comparable to that of nasopharyngeal aspirates for the detection of all major respiratory viruses except respiratory syncytial virus...
  46. pmc Clinical and financial benefits of rapid detection of respiratory viruses: an outcomes study
    J Barenfanger
    Laboratory Medicine, Memorial Medical Center, Springfield, Illinois 62781, USA
    J Clin Microbiol 38:2824-8. 2000
    ..Summarizing, the cytospin FA markedly decreased turnaround time and was associated with decreased mortality, length of stay, and costs and with better antibiotic stewardship...
  47. pmc Bats: important reservoir hosts of emerging viruses
    Charles H Calisher
    Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Clin Microbiol Rev 19:531-45. 2006
    ..From these summaries, it is clear that we do not know enough about bat biology; we are doing too little in terms of bat conservation; and there remain a multitude of questions regarding the role of bats in disease emergence...
  48. ncbi Mixed respiratory virus infections
    Glaucia Paranhos-Baccala
    Fondation Mérieux, Emerging Pathogens Laboratory, IFR128 Biosciences Lyon Gerland, Lyon, France
    J Clin Virol 43:407-10. 2008
    ..A better understanding of these various interactions would help future decision-making, such as the extent to which searches for co-pathogens should be conducted in severe bronchiolitis patients already infected by RSV...
  49. ncbi Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma
    P A B Wark
    Airways Research Centre, John Hunter Hospital, Newcastle, Australia
    Eur Respir J 19:68-75. 2002
    ..Higher levels of sputum LDH and ECP were associated with a longer hospital stay. Virus infection and acute asthma is associated with neutrophilic inflammation, cell lysis and more severe clinical disease...
  50. ncbi Real-time RT-PCR detection of 12 respiratory viral infections in four triplex reactions
    R N Gunson
    West of Scotland Specialist Virology Centre, Gartnavel General Hospital, Great Western Road, Glasgow G12 OYN, UK
    J Clin Virol 33:341-4. 2005
  51. ncbi Evolution of cell recognition by viruses
    E Baranowski
    , , Cantoblanco, 28049 Madrid, Spain
    Science 292:1102-5. 2001
    ..A capacity to exploit alternative entry pathways may reflect the ancient evolutionary origins of viruses and a possible role as agents of horizontal gene transfers among cells...
  52. ncbi Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response
    Gagik Oganesyan
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, 609 Charles E Young Dr East, Los Angeles, California 90095, USA
    Nature 439:208-11. 2006
    ..Our data demonstrate that TRAF3 is a major regulator of type I IFN production and the innate antiviral response...
  53. ncbi Multiplex real-time PCR for detection of respiratory tract infections
    Robin Brittain-Long
    Department of Infection, The Sahlgrenska Academy, Goteborg University, 416 85 Goteborg, Sweden
    J Clin Virol 41:53-6. 2008
    ..Broad diagnostics of respiratory infection by molecular assays has not yet won acceptance due to technical difficulties and high costs...
  54. ncbi Viral mechanisms of immune evasion
    A Alcami
    Divn of Virology, Dept of Pathology, University of Cambridge, Tennis Court Road, Cambridge, UK CB2 1QP
    Immunol Today 21:447-55. 2000
    ..Our knowledge of viral gene functions must be integrated into virus-host interaction networks to understand viral pathogenesis, and could lead to new anti-viral strategies and the ability to exploit viral functions as tools in medicine...
  55. pmc Comparison of the Luminex xTAG RVP Fast assay and the Idaho Technology FilmArray RP assay for detection of respiratory viruses in pediatric patients at a cancer hospital
    N Esther Babady
    Clinical Microbiology Service, Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Clin Microbiol 50:2282-8. 2012
    ..The sensitivity, simplicity, and random-access platform make FA RVP an excellent choice for laboratory on-demand service with low to medium volume...
  56. ncbi Causes of acute, undifferentiated, febrile illness in rural Thailand: results of a prospective observational study
    C Suttinont
    Department of Medicine, Maharat Nakhon Ratchasima Hospital, Amphur Mueng, Nakhon Ratchasima Province, 30000, Thailand
    Ann Trop Med Parasitol 100:363-70. 2006
    ..Leptospirosis and rickettsioses, especially scrub typhus, were thus found to be major causes of acute, undifferentiated fever in Thai agricultural workers...
  57. ncbi Comparative evaluation of the Seegene Seeplex RV15 and real-time PCR for respiratory virus detection
    David F Bibby
    Department of Virology, Barts and The London NHS Trust, London, UK
    J Med Virol 83:1469-75. 2011
    ..The high throughput capabilities and potential lower technical requirements afforded by the Seeplex® system may offer an alternative to real-time RT-PCR systems...
  58. ncbi Air pollution and respiratory viral infection
    Jonathan Ciencewicki
    Curriculum of Toxicology, University of North Carolina, Chapel Hill, North Carolina, USA
    Inhal Toxicol 19:1135-46. 2007
  59. pmc Rapid identification viruses from nasal pharyngeal aspirates in acute viral respiratory infections by RT-PCR and electrospray ionization mass spectrometry
    Kuan Fu Chen
    Johns Hopkins University, Department of Medicine, Baltimore, MD 21205, USA
    J Virol Methods 173:60-6. 2011
    ..Time to first result of RT-PCR/ESI-MS was 8h. RT-PCR/ESI-MS demonstrated capacity to detect respiratory viruses identifiable and unidentifiable by conventional methods rapidly...
  60. ncbi Emerging viruses: coming in on a wrinkled wing and a prayer
    Kim Halpin
    Australian Animal Health Laboratory, Commonwealth Scientific and Industrial Research Organization Livestock Industries, Geelong, Australia
    Clin Infect Dis 44:711-7. 2007
    ..The public health and trade impacts of several outbreaks are also discussed. Finally, we attempt to predict where, when, and why we may see the emergence of new chiropteran viruses...
  61. pmc Comparison of three multiplex PCR assays for the detection of respiratory viral infections: evaluation of xTAG respiratory virus panel fast assay, RespiFinder 19 assay and RespiFinder SMART 22 assay
    Mareike Dabisch-Ruthe
    Institut fur Laboratoriums und Transfusionsmedizin, Herz und Diabeteszentrum Nordrhein Westfalen, Universitatsklinik der Ruhr Universitat Bochum, Bad Oeynhausen, Germany
    BMC Infect Dis 12:163. 2012
    ..Therefore, the identification of the causative viruses and bacteria is only feasible using multiplex PCR or several monoplex PCR tests in parallel...
  62. pmc Heterologous immunity provides a potent barrier to transplantation tolerance
    Andrew B Adams
    Emory Transplant Center and Department of Surgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Clin Invest 111:1887-95. 2003
    ..These data offer a potential explanation for the difficulty encountered when inducing tolerance in nonhuman primates and human patients and provide insight into the signaling pathways essential for memory T cell activation and function...
  63. ncbi Melatonin in bacterial and viral infections with focus on sepsis: a review
    Venkataramanujam Srinivasan
    Sri Sathya Sai Medical Educational and Research Foundation Prasanthi Nilayam, 40 Kovai Thirunagar, Coimbatore 641014, Tamilnadu, India
    Recent Pat Endocr Metab Immune Drug Discov 6:30-9. 2012
    ..The patents related to melatonin's use for treatment of bacterial infections and its use in clinical disorders are included...
  64. pmc Yield of sputum for viral detection by reverse transcriptase PCR in adults hospitalized with respiratory illness
    Ann R Falsey
    University of Rochestera and Rochester General Hospital, b Rochester, New York, USA
    J Clin Microbiol 50:21-4. 2012
    ..Further studies designed to adapt the use of sputum samples for commercial RT-PCR respiratory virus assays are needed...
  65. ncbi Viral etiology of respiratory infections in children under 5 years old living in tropical rural areas of Senegal: The EVIRA project
    Mbayame Ndiaye Niang
    Unit of Medical Virology, Institut Pasteur of Dakar, Dakar, Senegal
    J Med Virol 82:866-72. 2010
  66. ncbi Broad respiratory virus detection in infants hospitalized for bronchiolitis by use of a multiplex RT-PCR DNA microarray system
    Antoine Huguenin
    Medical and Molecular Virology Unit and EA 484, University Hospital Center and Medical School of Reims, Reims, France
    J Med Virol 84:979-85. 2012
    ..It should improve the clinical management, the epidemiological survey, and the prevention of the nosocomial transmission of respiratory viruses in pediatric wards...
  67. pmc Squalamine as a broad-spectrum systemic antiviral agent with therapeutic potential
    Michael Zasloff
    Transplant Institute, Department of Surgery, Georgetown University Medical Center, Washington, DC 20007, USA
    Proc Natl Acad Sci U S A 108:15978-83. 2011
    ..Because squalamine can be readily synthesized and has a known safety profile in man, we believe its potential as a broad-spectrum human antiviral agent should be explored...
  68. pmc Translating DRiPs: progress in understanding viral and cellular sources of MHC class I peptide ligands
    Brian P Dolan
    Laboratory of Viral Diseases, NIAID, Bethesda, MD 20892, USA
    Cell Mol Life Sci 68:1481-9. 2011
  69. ncbi Evaluation of commercial ResPlex II v2.0, MultiCode-PLx, and xTAG respiratory viral panels for the diagnosis of respiratory viral infections in adults
    Joan Miquel Balada-Llasat
    Clinical Microbiology, Department of Pathology, The Ohio State University Medical Center, 1492 E Broad Street, Columbus, OH 43205, United States
    J Clin Virol 50:42-5. 2011
    ..The MultiCode-PLX assay detects 229E, OC43, and NL63, differentiates parainfluenza 4a, 4b and adenoviruses (B, C, E). The xTAG additionally subtypes influenza A as seasonal H1 and H3...
  70. ncbi Mixed viral infections causing acute gastroenteritis in children in a waterborne outbreak
    S Räsänen
    University of Tampere Medical School, Tampere, Finland
    Epidemiol Infect 138:1227-34. 2010
    ..Bloody diarrhoea occurred only when C. jejuni was present. To conclude, massive exposure to several AGE viruses caused mixed infections and severe AGE regardless of the aetiological agents...
  71. ncbi Respiratory viruses in children admitted to hospital intensive care units: evaluating the CLART® Pneumovir DNA array
    Emilie Frobert
    Laboratoire de Virologie Est, Centre de biologie et pathologie est, Hospices Civils de Lyon, Bron Cedex, Lyon, France
    J Med Virol 83:150-5. 2011
    ..The CLART® Pneumovir DNA array was useful for examining severe viral respiratory infections, when other viruses than those detected by conventional methods could be involved, particularly in an ICU...
  72. pmc RNA-based viral immunity initiated by the Dicer family of host immune receptors
    Roghiyh Aliyari
    Department of Plant Pathology and Microbiology, Institute for Integrative Genome Biology, University of California, Riverside, CA 92521, USA
    Immunol Rev 227:176-88. 2009
    ..We also highlight some of the many unresolved questions...
  73. ncbi A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA
    Ken J Ishii
    Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Nat Immunol 7:40-8. 2006
    ..These results suggest that both TBK1 and IKKi are required for innate immune activation by B-DNA, which might be important in antiviral innate immunity and other DNA-associated immune disorders...
  74. pmc Viruses and asthma
    Daniel E Dulek
    Department of Pediatrics, Division of Pediatric Infectious Diseases, Monroe Carell Jr Children s Hospital at Vanderbilt, Vanderbilt University Medical Center, Nashville, TN 37232 2650, USA
    Biochim Biophys Acta 1810:1080-90. 2011
    ..Over the last 20years much effort has been put into clarifying the role that viral respiratory infections play in the eventual development of asthma...
  75. ncbi Viral evasion and subversion of pattern-recognition receptor signalling
    Andrew G Bowie
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Nat Rev Immunol 8:911-22. 2008
  76. pmc Evidence from multiplex molecular assays for complex multipathogen interactions in acute respiratory infections
    John D Brunstein
    Centre for Translational and Applied Genomics, PHSA Labs, Children s and Women s Health Centre of BC, PHSA, Vancouver, British Columbia, Canada
    J Clin Microbiol 46:97-102. 2008
  77. ncbi Frontiers in nephrology: heterologous immunity, T cell cross-reactivity, and alloreactivity
    Liisa K Selin
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Am Soc Nephrol 18:2268-77. 2007
  78. pmc Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection
    Susan M Kaech
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06437, USA
    Immunity 27:393-405. 2007
    ..Here we discuss recent findings that might help redefine how heterogeneity in antiviral T cell populations gives rise to T cell subsets with short- and long-lived cell fates...
  79. ncbi Development and implementation of a molecular diagnostic platform for daily rapid detection of 15 respiratory viruses
    Annika Tiveljung-Lindell
    Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden
    J Med Virol 81:167-75. 2009
    ..The new platform was introduced in the laboratory in October 2007 and has then fully replaced the standard immunofluorescence assay for rapid detection of viruses and virus isolation...
  80. ncbi Genomic survey of early responses to viruses in Atlantic salmon, Salmo salar L
    Aleksei Krasnov
    Nofima, 1432 As, Norway
    Mol Immunol 49:163-74. 2011
    ..Apparently, a number of genes involved in antiviral responses in salmon have acquired different functional roles in higher vertebrates...
  81. pmc NKT cell immune responses to viral infection
    Marlowe S Tessmer
    Brown University, Department of Molecular Microbiology and Immunology, Providence, USA
    Expert Opin Ther Targets 13:153-62. 2009
    ..The multifaceted methods of activation iNKT cells possess and their ability to produce regulatory cytokines has made them a primary target for studies...
  82. ncbi Strong association between respiratory viral infection early after hematopoietic stem cell transplantation and the development of life-threatening acute and chronic alloimmune lung syndromes
    A Birgitta Versluys
    Department of Pediatric Hematology Immunology and Bone Marrow Transplantation, University Medical Center Utrecht Wilhelmina Children s Hospital, Utrecht, The Netherlands
    Biol Blood Marrow Transplant 16:782-91. 2010
    ..004). We hypothesize that early infection of the respiratory tract with a common cold virus makes the lungs a target for alloimmunity...
  83. pmc Comparison of the Luminex Respiratory Virus Panel fast assay with in-house real-time PCR for respiratory viral infection diagnosis
    Naomi J Gadsby
    Specialist Virology Centre, Department of Laboratory Medicine, Royal Infirmary of Edinburgh, Little France Crescent, Edinburgh, EH16 4SA, United Kingdom
    J Clin Microbiol 48:2213-6. 2010
  84. ncbi Respiratory viruses in hospitalized children with acute lower respiratory tract infections in harbin, China
    Hong Yan Zhang
    Department of Pediatrics, The First Affiliated Hospital of Harbin Medical University, Harbin, China
    Jpn J Infect Dis 62:458-60. 2009
    ..The study results will help determine the etiologic agents of ALRI in children and establish prevention and treatment programs...
  85. pmc Comparison of real-time PCR assays with fluorescent-antibody assays for diagnosis of respiratory virus infections in children
    Jane Kuypers
    Department of Laboratory Medicine, University of Washington, 4800 Sand Point Way NE, Room W8814, Seattle, WA 98105, USA
    J Clin Microbiol 44:2382-8. 2006
    ..Use of real-time PCR to identify viral respiratory pathogens in children will lead to improved diagnosis of respiratory illness...
  86. pmc Etiology and clinical course of febrile neutropenia in children with cancer
    Hana Hakim
    Departments of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Pediatr Hematol Oncol 31:623-9. 2009
    ..The etiology, clinical course, and outcome of fever and neutropenia (FN) in children with cancer using the current FN guidelines and diagnostic resources in the United States have not been well described...
  87. ncbi Epidemiology of viral respiratory tract infections in a prospective cohort of infants and toddlers attending daycare
    Mary P Fairchok
    Department of Pediatrics, Madigan Army Medical Center, Bldg 9040 Fitzsimmons Drive, Tacoma, WA 98431, United States
    J Clin Virol 49:16-20. 2010
    ..The epidemiology of respiratory tract infections (RTIs) in a daycare cohort has not been explored using molecular techniques...
  88. pmc Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity
    Paola M Barral
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA, USA
    Pharmacol Ther 124:219-34. 2009
    ..We also consider the function of these cytoplasmic sensors in apoptosis, development and differentiation, and diabetes...
  89. pmc Respiratory viruses other than influenza virus: impact and therapeutic advances
    W Garrett Nichols
    GlaxoSmithKline, London, United Kingdom
    Clin Microbiol Rev 21:274-90, table of contents. 2008
  90. pmc Detection of multiple respiratory pathogens during primary respiratory infection: nasal swab versus nasopharyngeal aspirate using real-time polymerase chain reaction
    T J Meerhoff
    NIVEL Netherlands Institute for Health Services Research, Utrecht, The Netherlands
    Eur J Clin Microbiol Infect Dis 29:365-71. 2010
  91. ncbi Viral pathogens associated with acute respiratory infections in central vietnamese children
    Lay Myint Yoshida
    Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
    Pediatr Infect Dis J 29:75-7. 2010
    ..5%), parainfluenza virus (5%), and bocavirus (2%). These Vietnamese children had a range of respiratory viruses which underscores the need for enhanced acute respiratory infection surveillance in tropical developing countries...
  92. pmc Viral infections of the lower respiratory tract: old viruses, new viruses, and the role of diagnosis
    Andrew T Pavia
    Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Utah, Salt Lake City, UT 84108, USA
    Clin Infect Dis 52:S284-9. 2011
    ..In addition, rapid identification of viral infections can help control nosocomial transmission...
  93. pmc Genome-virome interactions: examining the role of common viral infections in complex disease
    Ellen F Foxman
    Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut 06520, USA
    Nat Rev Microbiol 9:254-64. 2011
  94. ncbi Respiratory viral infections after bone marrow/peripheral stem-cell transplantation: the Christie hospital experience
    I A Hassan
    Department of Microbiology, Manchester Royal Infirmary, Manchester, UK
    Bone Marrow Transplant 32:73-7. 2003
    ..This study further supports the role played by human respiratory viruses in transplant-associated morbidity and mortality, and particularly highlights the significance of rhinovirus infections...
  95. pmc Frequent detection of respiratory viruses without symptoms: toward defining clinically relevant cutoff values
    Rogier R Jansen
    Department of Medical Microbiology1 and Department of Pediatrics, 2 Academical Medical Centre, University of Amsterdam, Amsterdam, Netherlands
    J Clin Microbiol 49:2631-6. 2011
    ..This suggests that defining cutoff levels should be feasible and represents the next necessary step for diagnosing viral respiratory infections using molecular tests...
  96. pmc Comparison of the FilmArray Respiratory Panel and Prodesse real-time PCR assays for detection of respiratory pathogens
    M J Loeffelholz
    Department of Pathology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0740, USA
    J Clin Microbiol 49:4083-8. 2011
    ..In this population of young children with upper respiratory tract infection, RV/EV accounted for the majority of the additional pathogens detected by FilmArray RP...
  97. ncbi How do viral infections predispose patients to bacterial infections?
    Carol Beadling
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA
    Curr Opin Infect Dis 17:185-91. 2004
    ..Understanding the 'lethal synergism' associated with concomitant infections may point the way toward improved anti-sepsis treatments...
  98. pmc High burden of non-influenza viruses in influenza-like illness in the early weeks of H1N1v epidemic in France
    Nathalie Schnepf
    Universite Paris Diderot, Sorbonne Paris Cité, Microbiology Department, Saint Louis Hospital, APHP, Paris, France
    PLoS ONE 6:e23514. 2011
    ..Clinical observations are of little help to recognise myxovirus infection and implement appropriate prevention measures. The limited use of molecular tools underestimates the role of other common pathogens...
  99. ncbi Evaluation of multiple commercial molecular and conventional diagnostic assays for the detection of respiratory viruses in children
    F Gharabaghi
    Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, ON, Canada
    Clin Microbiol Infect 17:1900-6. 2011
    ..Using 75 positive and 55 negative nasopharyngeal swabs for influenza A by the Astra assay, the sensitivity of Seeplex and Resplex was 95.9% and 91.8%, respectively, with a specificity of 100% for both...
  100. ncbi Epitope discovery and their use in peptide based vaccines
    Nadine L Dudek
    The Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Victoria 3010, Australia
    Curr Pharm Des 16:3149-57. 2010
    ..We discuss the potential of peptide-based vaccines for the treatment of chronic viral diseases and cancer and review recent developments in the field of epitope discovery and peptide-based vaccines...
  101. ncbi Rituximab-related viral infections in lymphoma patients
    Sercan Aksoy
    Department of Medical Oncology, Hacettepe University Institute of Oncology, Ankara, Turkey
    Leuk Lymphoma 48:1307-12. 2007
    ..Close monitoring for viral infection, particularly HBV and CMV, in patients treated with rituximab should be recommended...

Research Grants75

  1. Genomics of Antiviral Responses of Anopheles gambiae Against O'nyong-nyong Virus
    Young S Hong; Fiscal Year: 2010
    ..Considering there exist overlapping immune responses against bacterial and malaria infections in An. gambiae, our findings may also provide information applicable to Plasmodium infection. ..
    DHAN V KALVAKOLANU; Fiscal Year: 2013
    ..Studies proposed in this application will investigate the regulation of an anti-metastatic gene, DAPK1, which is critical for tumor suppression and autophagic responses. ..
  3. Novel DNA-Launched Attenuated Vaccine for VEE Virus
    PETER M PUSHKO; Fiscal Year: 2012
    ..If successful, this technology can potentially transform the field of live attenuated vaccines for many viral diseases. ..
  4. Thirteenth Annual Meeting of the Rocky Mountain Virology Association
    Joel Rovnak; Fiscal Year: 2013
    ..The RMVA has been an outstanding source of communication and collaboration for the Rocky mountain region. ..
  5. Innate Immune Mechanisms of Motor Neuron Injury
    Timothy Vartanian; Fiscal Year: 2010
    ..We have identified a receptor termed TLR3 present on all neurons, that when activated, induces death to only motor neurons. This application pursues research to define the relevance of this finding to diseases of the motor neuron. ..
  6. Diagnostic array for aseptic encephalitis
    Darrell P Chandler; Fiscal Year: 2011
    ..The underlying platform developed herein will likewise find broad application in many areas of infectious disease diagnostics. ..
  7. Virus interference with Toll like Receptor Response on Dendritic Cells
    Elina I Zuniga; Fiscal Year: 2010
    ..This proposal addresses the mechanisms by which DC-TLR responses are altered during viral infections and thus has the potential to provide novel therapeutic strategies to fight-off opportunistic pathogens associated with viral diseases. ..
  8. Biophysics of Drug Interactions with Viral Episomes
    James K Bashkin; Fiscal Year: 2013
  9. Rabies virus maintenance in bat populations
    APRIL DAWN DAVIS; Fiscal Year: 2013
    ..Completion of the studies described in this proposal will provide data integral to infectious disease modeling and improve our knowledge of the public health risks associated with bat rabies. ..
  10. Mechanisms of apoptosis in the central nervous system
    Kenneth Tyler; Fiscal Year: 2009
    ..In addition, the proposed studies will evaluate the role of these genes and pathways as novel therapeutic targets for these diseases. ..
  11. The Mechanisms of IFITM-Mediated Restriction
    I Chueh Huang; Fiscal Year: 2013
    ..I am situated in a highly supportive and intellectually rich environment in which I can pursue my scientific and career development goals. ..
  12. Bioavailable proteasome inhibitors as broad-spectrum antivirals
  13. Development of a Recombinant Subunit Vaccine for CCHF
    David E Clements; Fiscal Year: 2013
    ..The successful development of a CCHF recombinant subunit vaccine based on this platform supports the concept that a single platform can be utilized to produce vaccines against a number of viral priority pathogens. ..
  14. Surrogate endpoints for correlating protective immunity in response to influenza
    Gary Fujii; Fiscal Year: 2010
  15. Ribozymes for studies and treatment of cytomegalovirus infections
    Fenyong Liu; Fiscal Year: 2012
    ..Our study will facilitate the development of novel macromolecules that can be used as research tools and therapeutic agents for studies and treatment of infections of human viruses including HCMV. ..
  16. Role of HCV Sequence Variation in Pathology
    John E Tavis; Fiscal Year: 2010
    ..This will yield insight into the mechanism of pathology by identifying viral genes associated with differences in disease progression. Finally, these studies may identify viral motifs predictive of rapid disease advancement. ..
  17. Antibody immunotherapeutics for biodefense against Lassa virus
    Robert F Garry; Fiscal Year: 2013
    ..This proposed effort will result in a new class of immunotherapeutics for LF. ..
  18. The roles of acidic autophagosomes in production of infectious poliovirus
    William T Jackson; Fiscal Year: 2013
    ..This work is also an important step in understanding the mechanisms of existing and future therapeutic agents against multiple viral diseases. ..
  19. Bacteria Based Agents for Therapy of AIDS Associated Infections
    Sangwei Lu; Fiscal Year: 2010
    ..Our study will facilitate the development of a new method that can be used as a research tool and a therapeutic approach for studies and treatment of infections associated with human viruses such as HCMV. ..
  20. Cellular Determinants of Apoptosis in Virus-Infected Cells
    Ganes C Sen; Fiscal Year: 2012
    ..For this purpose, the different steps of the viral life cycle will be examined. Moreover, the status of the innate immune response in the persistently infected cells will be evaluated. ..
  21. New Alphavirus Expression Systems in Mosquitoes
    Kenneth E Olson; Fiscal Year: 2012
  22. Metabolic approaches to treat severe viral and inflammatory diseases
    Augusto C Ochoa; Fiscal Year: 2013
  23. Functional Dynamics of Mammalian and Viral DNA Repair Polymerases
    W M BUJALOWSKI; Fiscal Year: 2013
  24. Upgrade of Our Thermo LTQ to a LTQ Orbitrap XL ETD Mass Spectrometer
    C Robert Matthews; Fiscal Year: 2010
    ..This unique and powerful insights obtained will increase our understanding of the molecular basis for disease and, thereby, provide a rationale for the development of therapeutic treatments for a spectrum of human pathologies. ..
  25. Therapeutics that target processivity complex proteins of pox and other viruses
    ROBERT PAUL RICCIARDI; Fiscal Year: 2013
    ..The Broad-Spectrum action of certain of these therapeutics will hopefully generate new anti-virals that can be used to prevent current infections that are of medical significance as well as block other important agents of bioterrorism. ..
  26. Viral recognition by plasmacytoid dendritic cell
    Akiko Iwasaki; Fiscal Year: 2013
  27. Control of Viral Pathogenesis by Regulation of 2-5A Levels
    Susan R Weiss; Fiscal Year: 2013
  28. EID - Effects of avian migration & anthropogenic change on the distribution & tra
    Thomas Smith; Fiscal Year: 2009
    ..Finally, we will share our results with public health organizations and the scientific community in a timely fashion in order to maximize the public good. ..
  29. Super-resolution studies of the entry mechanisms of influenza viruses
    Xiaowei Zhuang; Fiscal Year: 2013
    ..Furthermore, the super-resolution imaging approach developed here will have broad applications in many areas of biomedical research. ..
  30. Western Regional Center of Excellence for Biodefense and Emerging Infectious Dise
    David H Walker; Fiscal Year: 2013
    ..abstract_text> ..
  31. Label-free HIV-1 Viral Load Measurement through a Contactless Electrode Microchip
    Hadi Shafiee; Fiscal Year: 2013
    ..This proposal will provide an inexpensive method for HIV-1 viral load measurements at POC that is compatible with mass fabrication technologies with a great promise to be commercialized. ..
  32. A Novel Method of Generating Hepatitis C Virus-Like Particles using Lentivirus
    Boro Dropulic; Fiscal Year: 2009
    ..The technology can be used in multiple formats, and in particular related to this RFA it can be used for rapid production of virus-like particles from human cells. ..
  33. Novel host factors in selective autophagy of viruses
    Rhea M Sumpter; Fiscal Year: 2013
  34. Physical and functional probing of DEAD-box proteins as general RNA chaperones
    Rick Russell; Fiscal Year: 2013
  35. Developing Anti-viral Ribozymes to Suppress Arboviruses in Transgenic Mosquitoes
    Malcolm J Fraser; Fiscal Year: 2013
    ..The ultimate goal is to be able to provide mosquito strains that will be useful in simultaneously eliminating two or more of these viral diseases. ..
    Ganes C Sen; Fiscal Year: 2013
    ..For combating virus infection, the interferon system is the most important component of the mammalian innate immune system and here we propose to study its functions. ..
    Paul D Friesen; Fiscal Year: 2010
    ..Collectively, these studies are expected to provide new and fundamental information on virus-host interactions during apoptosis of animal cells. ..
  38. A molecular basis for control of T cell memory
    Stephen M Hedrick; Fiscal Year: 2013
    ..The results will have direct implications for the progression of long co-evolved viral diseases such as HIV, Herpes, and Hepatitis C virus. ..
  39. Development of a therapy for Smallpox, Vaccinia, and Monkeypox
    Alexander Rich; Fiscal Year: 2010
    ..Due to concerns about bioterrorism, it is important to have such drugs available in case of an attack. ..
  40. Control of influenza virus by sphingolipid metabolism
    Bumsuk Hahm; Fiscal Year: 2013
  41. The Role of Proteasomes in Viral RNA Translation
    Evgeny V Pilipenko; Fiscal Year: 2010
    ..Hence, our research may also aid to the development of new approaches for therapeutic intervention of medically important non-viral human diseases. ..
    Erol Fikrig; Fiscal Year: 2010
    ..Furthermore, anticipating the 24- hour rhythms of innate immune recognition mechanisms of viral infection may be extremely useful for the design and optimization of therapeutic and immunoprophylactic protocols. ..
  43. 2013 Nucleosides, Nucleotides, and Oligonucleotides Gordon Research Conference
    William B Parker; Fiscal Year: 2013
    ..This conference is therefore highly significant regarding its health relatedness, as the discussions among chemists and biologists will generate new knowledge and avenues for development of novel therapeutics. ..
  44. Agonists of the RIG-I Innate Immune Pathway
    SHAWN PATRICK IADONATO; Fiscal Year: 2013
    ..The significance of the program derives from the global burden of viral diseases that may be addressed by these new drug candidates. ..
  45. Developing Transmissible Antivirals by Exploiting Gene-Expression Circuitry
    Leor Weinberger; Fiscal Year: 2009
    ..Clearly, new and more effective antiviral strategies are needed and this proposal presents a multi-pronged approach to identify and develop an innovative new antiviral approach. ..
  46. Development of IFN-lambda3 for the Prevention and Treatment of Virus Infection
    Sergei V Kotenko; Fiscal Year: 2013
    ..The long-term goal of this project is to develop IFN-?-based broad-spectrum antiviral therapeutics and bring them into the clinic. ..
  47. Research Training in Comparative Viral Pathogenesis
    Charles Wood; Fiscal Year: 2013
    ..There is an urgent national need to provide training to individuals with the potential to perform high-quality research in viral pathogenesis and equip them to be productive throughout their careers. ..
  48. Virology of the Central Nervous System
    John H Elder; Fiscal Year: 2010
    ..Academic and investigative performance;2) evidence of commitment to biomedical research, in particular to virus diseases of the CNS;and 3) recommendations from previous mentors...
  49. Identification of novel influenza antivirals
    GREGORY WILLIAM HENKEL; Fiscal Year: 2012
    ..Using this approach we propose to identify inhibitory compounds acting at a novel influenza A target site for the development of new broad-spectrum influenza drug therapies. ..
  50. Akt as a therapeutic target for respiratory syncytial virus
    Michael N Teng; Fiscal Year: 2012
    ..We are proposing to identify and characterize a novel drug target of RSV that can potentially be used both prophylactically and therapeutically in a clinical setting. ..
  51. Emerging Viruses: Disease Models and Strategies for Vaccine Development
    KIMBERLY WEISS SCHUENKE; Fiscal Year: 2012
  52. Molecular, immunological, and clinical dissection of STAT1 hypermorphic mutations
    Steven M Holland; Fiscal Year: 2013
    ..The in-depth and integrated investigation of cells and patients with GOF STAT1 mutations has far- reaching and broad biological and clinical implications, for various physiological and pathological processes. ..
  53. Toll2011 Meeting, Decoding Innate Immunity
    ROBERT WILLIAM FINBERG; Fiscal Year: 2011
    ..The conference will also define the significant remaining scientific questions that need to be answered in order to advance future treatments for viral diseases. ..
  54. Constraints on the evolution of influenza oseltamivir resistance
    Jesse D Bloom; Fiscal Year: 2012
    ..The goal is to understand this escape at a molecular level, and use the resulting insight to anticipate potential future routes of oseltamivir resistance. ..
    David M Knipe; Fiscal Year: 2012
    ..An active and previously successful program by the training faculty and Division of Medical Sciences is described for the recruitment of underrepresented minority trainees. ..
  56. The Evolution of Bacteriophage Life History Traits
    Ing Nang Wang; Fiscal Year: 2013
    ..Because of the fundamental features shared among all viruses, insights and lessons gained from this proposed research should be applicable to all other viral diseases as well. ..
  57. Targeting dengue in the mosquito with small molecules
    MARIANO A GARCIABLANCO; Fiscal Year: 2013
  58. 1,2,3-Triazole nucleobases in antiviral nucleoside analogues
    ERLAND P STEVENS; Fiscal Year: 2010
    ..The drugs of interest resemble nucleic acids, the building blocks of genetic material in organisms. Viral diseases, including AIDS, herpes, and certain types of hepatitis, are often treated with drugs that can imitate nucleic acids. ..
  59. American Society for Virology Meeting
    Dorothea L Sawicki; Fiscal Year: 2013
    ..It is the conviction of the ASV that supporting virology research in this way enhances investigative efforts required to prevent and treat viral diseases and positively impacts U.S. efforts in public health. ..
    Otto O Yang; Fiscal Year: 2013
    ..This addition to the scientific workforce will increase the tempo of discovery of new approaches to combat AIDS and other chronic viral infections such as Hepatitis C. ..
  61. GUIDE: Genomic Uses in Infectious Diseases and Epidemics
    Jeffrey P Kahn; Fiscal Year: 2013
    ..g., HIV, HPV, tuberculosis), and broaden our reach to include additional categories of infectious disease such as insect-borne (e.g., malaria, Dengue fever, Chagas disease) and, perhaps, food-borne infections. ..
  62. Genomic Variability of Cytomegalovirus in a Clinical Setting
    Nicholas Renzette; Fiscal Year: 2010
    ..Hence, it will have direct impact on disease management of CMV and other viral diseases, while also creating technology useful for a new phase of molecular pathogenesis. ..
  63. Aedes anti-dengue immunity
    ..In addition to the basic knowledge generated by the proposed experiments, this project should also provide a variety of tools that can be used for the development of novel antiviral control strategies. ..
  64. Vidarabine Prodrugs as Anti-Pox Virus Agents
    John Hilfinger; Fiscal Year: 2007 collaboration with Dr. John Drach, an expert in the area of antiviral drugs at the University of Michigan. [unreadable] [unreadable] [unreadable]..
    Radhakrishnan Padmanabhan; Fiscal Year: 2003
    ..4. NS3/NS5 interaction is regulated by phosphorylation and subcellular location of NS5. The PI proposes to test the hypothesis that the nuclear NS5 regulates the expression of cellular gene(s) in response to viral infection. ..
    Krishna Murthy; Fiscal Year: 2004
    ..It will also permit a structural definition of alternate targets for inhibition of the protease and their detailed evaluation. ..
    WINIFRED DODDS; Fiscal Year: 1990
    ..Finally, synthesis and release of VWF from cultured endothelial cells will be studied in the presence and absence of thyroid hormones...
  68. Anti-Flavivirus Immunotherapeutics
    EILEEN NAKANO; Fiscal Year: 2001
    ..More than 250,000 annual cases of severe dengue disease are reported each year. ..
    Wayne Anderson; Fiscal Year: 1993
    ..Potential drug candidates which evolve from the proposed studies will be evaluated for water solubility, chemical stability and other properties that must be assessed in new drug development studies. ..
    Michael McChesney; Fiscal Year: 2000
    ..As a non tenure-track faculty member, his salary is not provided by the School and must be generated from research grants and contracts. ..
  71. The Aedes aegypti Genome Project
    David Severson; Fiscal Year: 2003
    ..The long range goal is to promote and foster collaboration between funding agencies to support an effort to sequence the entire A. aegypti genome. ..
  72. B.abortus-based vaccine against viral hemorrhagic fevers
    Ramesh Vemulapalli; Fiscal Year: 2004
    ..abstract_text> ..
  73. Determinants of RNA virus evolution
    ISABEL NOVELLA; Fiscal Year: 2009
    MARCELLA MCCLURE; Fiscal Year: 1999
    ..Strategies and techniques developed for the analysis of highly divergent genomes can also be applied to the study of the wealth of sequence information generated under the auspices of the Human Genome Project. ..
    LAURA POPE; Fiscal Year: 2000
    ..This is particularly true if an effective combination can be delivered as a topical formulation, emphasis of this research. ..