urinary incontinence

Summary

Summary: Inability to control the passage of URINE.

Top Publications

  1. ncbi Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study
    Debra E Irwin
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, United States
    Eur Urol 50:1306-14; discussion 1314-5. 2006
  2. ncbi The impact of overactive bladder, incontinence and other lower urinary tract symptoms on quality of life, work productivity, sexuality and emotional well-being in men and women: results from the EPIC study
    Karin S Coyne
    United BioSource Corporation, Bethesda, MD 20814, USA
    BJU Int 101:1388-95. 2008
  3. ncbi Urinary incontinence and its relationship to mental health and health-related quality of life in men and women in Sweden, the United Kingdom, and the United States
    Karin S Coyne
    United BioSource Corporation, Bethesda, MD 20814, USA
    Eur Urol 61:88-95. 2012
  4. ncbi Worldwide prevalence estimates of lower urinary tract symptoms, overactive bladder, urinary incontinence and bladder outlet obstruction
    Debra E Irwin
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA
    BJU Int 108:1132-8. 2011
  5. ncbi An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction
    Bernard T Haylen
    University of New South Wales, Sydney, New South Wales, Australia
    Neurourol Urodyn 29:4-20. 2010
  6. ncbi Efficacy and safety of onabotulinumtoxinA in patients with urinary incontinence due to neurogenic detrusor overactivity: a randomised, double-blind, placebo-controlled trial
    Francisco Cruz
    Department of Urology and IBMC, Hospital São João and Universidade Do Porto, Porto, Portugal
    Eur Urol 60:742-50. 2011
  7. ncbi ICIQ: a brief and robust measure for evaluating the symptoms and impact of urinary incontinence
    Kerry Avery
    Bristol Urological Institute, Southmead Hospital, Bristol, United Kingdom
    Neurourol Urodyn 23:322-30. 2004
  8. ncbi Preoperative pelvic floor muscle exercise for early continence after radical prostatectomy: a randomised controlled study
    Antonia Centemero
    Department of Urology, Vita Salute University, San Raffaele Turro Hospital, Milan, Italy
    Eur Urol 57:1039-43. 2010
  9. ncbi Pelvic organ prolapse and incontinence in developing countries: review of prevalence and risk factors
    Godfrey J A Walker
    Cochrane Pregnancy and Childbirth Group, School of Reproductive and Developmental Medicine, Division of Perinatal and Reproductive Medicine, University of Liverpool, Liverpool, UK
    Int Urogynecol J 22:127-35. 2011
  10. ncbi Phase 3 efficacy and tolerability study of onabotulinumtoxinA for urinary incontinence from neurogenic detrusor overactivity
    David Ginsberg
    Department of Urology, University of Southern California, Los Angeles, Norris Cancer Center, Los Angeles, CA 90033, USA
    J Urol 187:2131-9. 2012

Detail Information

Publications372 found, 100 shown here

  1. ncbi Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study
    Debra E Irwin
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, United States
    Eur Urol 50:1306-14; discussion 1314-5. 2006
    Estimate the prevalence of urinary incontinence (UI), overactive bladder (OAB), and other lower urinary tract symptoms (LUTS) among men and women in five countries using the 2002 International Continence Society (ICS) definitions.
  2. ncbi The impact of overactive bladder, incontinence and other lower urinary tract symptoms on quality of life, work productivity, sexuality and emotional well-being in men and women: results from the EPIC study
    Karin S Coyne
    United BioSource Corporation, Bethesda, MD 20814, USA
    BJU Int 101:1388-95. 2008
    ..To examine the effect overactive bladder (OAB) and other lower urinary tract symptoms (LUTS) on health-related quality of life (HRQoL) in a population sample, as OAB often occurs in conjunction with many other LUTS...
  3. ncbi Urinary incontinence and its relationship to mental health and health-related quality of life in men and women in Sweden, the United Kingdom, and the United States
    Karin S Coyne
    United BioSource Corporation, Bethesda, MD 20814, USA
    Eur Urol 61:88-95. 2012
    Differences in health burden associated with urinary incontinence (UI) subtypes have been previously described, but the majority of studies are in women...
  4. ncbi Worldwide prevalence estimates of lower urinary tract symptoms, overactive bladder, urinary incontinence and bladder outlet obstruction
    Debra E Irwin
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA
    BJU Int 108:1132-8. 2011
    ..predict worldwide and regional prevalence of lower urinary tract symptoms (LUTS), overactive bladder (OAB), urinary incontinence (UI) and LUTS suggestive of bladder outlet obstruction (LUTS/BOO) in 2008, 2013 and 2018 based on current ..
  5. ncbi An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction
    Bernard T Haylen
    University of New South Wales, Sydney, New South Wales, Australia
    Neurourol Urodyn 29:4-20. 2010
    ..Next to existing terminology of the lower urinary tract, due to its increasing complexity, the terminology for pelvic floor dysfunction in women may be better updated by a female-specific approach and clinically based consensus report...
  6. ncbi Efficacy and safety of onabotulinumtoxinA in patients with urinary incontinence due to neurogenic detrusor overactivity: a randomised, double-blind, placebo-controlled trial
    Francisco Cruz
    Department of Urology and IBMC, Hospital São João and Universidade Do Porto, Porto, Portugal
    Eur Urol 60:742-50. 2011
    Neurogenic detrusor overactivity (NDO) frequently results in urinary incontinence (UI) which impairs quality of life (QOL) and puts the upper urinary tract at risk.
  7. ncbi ICIQ: a brief and robust measure for evaluating the symptoms and impact of urinary incontinence
    Kerry Avery
    Bristol Urological Institute, Southmead Hospital, Bristol, United Kingdom
    Neurourol Urodyn 23:322-30. 2004
    To develop and evaluate the International Consultation on Incontinence Questionnaire (ICIQ), a new questionnaire to assess urinary incontinence and its impact on quality of life (QoL).
  8. ncbi Preoperative pelvic floor muscle exercise for early continence after radical prostatectomy: a randomised controlled study
    Antonia Centemero
    Department of Urology, Vita Salute University, San Raffaele Turro Hospital, Milan, Italy
    Eur Urol 57:1039-43. 2010
    Despite improvements in surgical techniques, urinary incontinence (UI) is not uncommon after radical prostatectomy (RP), and it may dramatically worsen quality of life (QoL).
  9. ncbi Pelvic organ prolapse and incontinence in developing countries: review of prevalence and risk factors
    Godfrey J A Walker
    Cochrane Pregnancy and Childbirth Group, School of Reproductive and Developmental Medicine, Division of Perinatal and Reproductive Medicine, University of Liverpool, Liverpool, UK
    Int Urogynecol J 22:127-35. 2011
    ..Information on the prevalence, risk factors and social consequences of pelvic floor dysfunction (PFD) affecting women in 16 low-income and lower middle-income countries is reviewed...
  10. ncbi Phase 3 efficacy and tolerability study of onabotulinumtoxinA for urinary incontinence from neurogenic detrusor overactivity
    David Ginsberg
    Department of Urology, University of Southern California, Los Angeles, Norris Cancer Center, Los Angeles, CA 90033, USA
    J Urol 187:2131-9. 2012
    ..We assessed the efficacy, safety and effects on quality of life of onabotulinumtoxinA in patients with neurogenic detrusor overactivity...
  11. pmc Prevalence and trends of urinary incontinence in adults in the United States, 2001 to 2008
    Alayne D Markland
    Birmingham Atlanta Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, University of Alabama at Birmingham, Birmingham, Alabama 35249 7333, USA
    J Urol 186:589-93. 2011
    We estimate trends in the prevalence of urinary incontinence in the adult population of the United States from 2001 through 2008 before and after adjusting for other potential associated factors.
  12. ncbi Urinary incontinence in women: variation in prevalence estimates and risk factors
    Vatche A Minassian
    Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Geisinger Medical Center, Danville, Pennsylvania 17822, USA
    Obstet Gynecol 111:324-31. 2008
    To understand variation in prevalence of urinary incontinence (UI) and risk factors, given different definitions.
  13. ncbi Urinary and sexual function after radical prostatectomy for clinically localized prostate cancer: the Prostate Cancer Outcomes Study
    J L Stanford
    Fred Hutchinson Cancer Research Center, Department of Epidemiology, University of Washington, Seattle 98109 1024, USA
    JAMA 283:354-60. 2000
    ..Patients with prostate cancer and their physicians need knowledge of treatment options and their potential complications, but limited data on complications are available in unselected population-based cohorts of patients...
  14. ncbi Systematic review and evaluation of methods of assessing urinary incontinence
    J L Martin
    Department of Health Sciences, University of Leicester, UK
    Health Technol Assess 10:1-132, iii-iv. 2006
    To identify and synthesise studies of diagnostic processes of urinary incontinence and to construct an economic model to examine the cost-effectiveness of simple, commonly used primary care tests.
  15. ncbi Botulinum toxin type a is a safe and effective treatment for neurogenic urinary incontinence: results of a single treatment, randomized, placebo controlled 6-month study
    Brigitte Schurch
    Spinal Cord Injury Centre, University Hospital Balgrist, Zurich, Switzerland
    J Urol 174:196-200. 2005
    ..the safety and efficacy of each of 2 doses of botulinum toxin type A (BTX-A) (200 or 300 U BOTOX) injected into the detrusor for urinary incontinence caused by neurogenic detrusor overactivity of predominantly spinal cord origin.
  16. ncbi Prevalence and burden of overactive bladder in the United States
    W F Stewart
    Department of Epidemiology, Johns Hopkins University, 615 North Wolfe Street, Room 6039E, Baltimore, MD 21205, USA
    World J Urol 20:327-36. 2003
    ..the National Overactive BLadder Evaluation (NOBLE) Program was initiated to better understand the prevalence and burden of overactive bladder in a broad spectrum of the United States population...
  17. ncbi Prevalence of overactive bladder, urinary incontinence, and lower urinary tract symptoms: results of Korean EPIC study
    Young Suk Lee
    Department of Urology, Sungkyunkwan University School of Medicine, Irwon Dong 50, Gangnam Gu, Seoul, 135 710, Korea
    World J Urol 29:185-90. 2011
    Despite growing interest in overactive bladder (OAB), urinary incontinence (UI), and lower urinary tract symptoms (LUTS), there is no epidemiologic study on the prevalence in general population of Korea...
  18. pmc Quality of life three years after diagnosis of localised prostate cancer: population based cohort study
    David P Smith
    Cancer Council, Kings Cross, New South Wales 1340, Australia
    BMJ 339:b4817. 2009
    ..To quantify the risk and severity of negative effects of treatment for localised prostate cancer on long term quality of life...
  19. ncbi Long-term effect of early postoperative pelvic floor biofeedback on continence in men undergoing radical prostatectomy: a prospective, randomized, controlled trial
    Lúcia Helena S Ribeiro
    Division of Urology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    J Urol 184:1034-9. 2010
    ..We tested the effectiveness of biofeedback-pelvic floor muscle training in improving urinary incontinence in the 12 months following radical prostatectomy.
  20. ncbi Pelvic floor exercise for urinary incontinence: a systematic literature review
    Natalia Price
    Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford, UK
    Maturitas 67:309-15. 2010
    b>Urinary incontinence is a common problem among adults and conservative management is recommended as the first-line treatment. Physical therapies, particularly pelvic floor muscle exercise, are the mainstay of such conservative management...
  21. ncbi Mirabegron, a β₃-adrenoceptor agonist for the potential treatment of urinary frequency, urinary incontinence or urgency associated with overactive bladder
    Pradeep Tyagi
    William Beaumont Hospital, Department of Urology, 3811 West 13 Mile Road, Royal Oak, MI 48073, USA
    IDrugs 13:713-22. 2010
    ....
  22. ncbi Urinary incontinence after radical prostatectomy: incidence by definition, risk factors and temporal trend in a large series with a long-term follow-up
    Emilio Sacco
    Department of Urology, University of Padova, Italy
    BJU Int 97:1234-41. 2006
    To investigate the incidence of urinary incontinence and its development over time, to compare the effects of alternative definitions on the incontinence rate and to explore risk factors for incontinence after radical retropubic ..
  23. ncbi Efficacy of an assisted low-intensity programme of perioperative pelvic floor muscle training in improving the recovery of continence after radical prostatectomy: a randomized controlled trial
    Daniele Tienforti
    Department of Urology, Agostino Gemelli Hospital, Catholic University Medical School, Rome, Italy
    BJU Int 110:1004-10. 2012
    ..known on the subject? and What does the study add? Peri-operative pelvic floor muscle training reduces urinary incontinence for men undergoing radical prostatectomy (RP)...
  24. ncbi Comparisons of approaches to pelvic floor muscle training for urinary incontinence in women
    E Jean C Hay-Smith
    Rehabilitation Teaching and Research Unit, Department of Medicine, University of Otago, Wellington, New Zealand
    Cochrane Database Syst Rev 12:CD009508. 2011
    ..floor muscle training is the most commonly recommended physical therapy treatment for women with stress urinary incontinence. It is also sometimes recommended for mixed and, less commonly, urge urinary incontinence...
  25. ncbi Association between the Geriatric Giants of urinary incontinence and falls in older people using data from the Leicestershire MRC Incontinence Study
    Anne L Foley
    Department of Medicine for the Elderly, Aintree University Hospitals NHS Foundation Trust, Longmoor Lane, Liverpool L9 7AL, UK
    Age Ageing 41:35-40. 2012
    To determine whether urinary incontinence per se and different types of urinary incontinence individually are associated with an increased risk of falls in those aged 70 years and over...
  26. ncbi Urinary incontinence in men after formal one-to-one pelvic-floor muscle training following radical prostatectomy or transurethral resection of the prostate (MAPS): two parallel randomised controlled trials
    Cathryn Glazener
    Health Services Research Unit, University of Aberdeen, Foresterhill, Aberdeen, UK
    Lancet 378:328-37. 2011
    b>Urinary incontinence is common immediately after prostate surgery. Men are often advised to do pelvic-floor exercises, but evidence to support this is inconclusive...
  27. ncbi Efficacy of botulinum toxin A injection for neurogenic detrusor overactivity and urinary incontinence: a randomized, double-blind trial
    Sender Herschorn
    Division of Urology, University of Toronto, Sunnybrook Health Sciences Centre, Room A309, 2075 Bayview Ave, Toronto, Ontario M4N 3M5, Canada
    J Urol 185:2229-35. 2011
    ..We determined the efficacy of onabotulinumtoxinA for neurogenic detrusor overactivity secondary to spinal cord injury or multiple sclerosis...
  28. ncbi Artificial urinary sphincter for post-radical prostatectomy urinary incontinence: long-term subjective results
    A E Gousse
    Urology Department, University of Miami, Jackson's Memorial Hospital, Miami, Florida, USA
    J Urol 166:1755-8. 2001
    ..A standard definition of treatment success and studies of homogenous groups of patients with an artificial urinary sphincter would enable better understanding and patient education in the future...
  29. ncbi Early outcomes from three prospective trials of image-guided proton therapy for prostate cancer
    Nancy P Mendenhall
    University of Florida Proton Therapy Institute, Jacksonville, FL 32206, USA
    Int J Radiat Oncol Biol Phys 82:213-21. 2012
    ..To report early outcomes with image-guided proton therapy for prostate cancer...
  30. ncbi How widespread are the symptoms of an overactive bladder and how are they managed? A population-based prevalence study
    I Milsom
    Department of Obstetrics and Gynaecology, Sahlgrenska University Hospital, Goteborg, Sweden, Bristol Urological Institute, Southmead Hospital, Bristol, UK
    BJU Int 87:760-6. 2001
    ....
  31. ncbi A prospective study evaluating the efficacy of the artificial sphincter AMS 800 for the treatment of postradical prostatectomy urinary incontinence and the correlation between preoperative urodynamic and surgical outcomes
    Flavio Trigo Rocha
    Division of Urology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    Urology 71:85-9. 2008
    ..efficacy of the artificial urinary sphincter (AUS) AMS 800 for the treatment postradical prostatectomy urinary incontinence (PRPUI) patients...
  32. ncbi Prioritizing research: Patients, carers, and clinicians working together to identify and prioritize important clinical uncertainties in urinary incontinence
    Brian S Buckley
    Department of General Practice, National University of Ireland, Galway, Ireland
    Neurourol Urodyn 29:708-14. 2010
    ..This partnership of patients and clinicians aimed to identify and prioritize "clinical uncertainties" relating to treatment of urinary incontinence (UI).
  33. ncbi Two-stage transperineal management of posterior urethral strictures or bladder neck contractures associated with urinary incontinence after prostate surgery and endoscopic treatment failures
    Alchiede Simonato
    Luciano Giuliani Department of Urology, University of Genoa, Genoa, Italy
    Eur Urol 52:1499-504. 2007
    The treatment of posterior urethral strictures or bladder neck contracture associated with severe urinary incontinence after prostate surgery and failure of endoscopic treatments is controversial...
  34. ncbi Impact of functional results on quality of life after rectal cancer surgery
    Jaana H Vironen
    Helsinki University Central Hospital, Jorvi Hospital, Espoo, Finland
    Dis Colon Rectum 49:568-78. 2006
    ..Quality of life is an important outcome measure that has to be considered when deciding treatment strategy for rectal cancer. The aim of this study was to find out the impact of surgery-related adverse effects on quality of life...
  35. ncbi Effect of childhood dysfunctional voiding on urinary incontinence in adult women
    Vatche A Minassian
    Division of Urogynecology, Department of Obstetrics and Gynecology, Geisinger Health System, Danville, Pennsylvania 17822, USA
    Obstet Gynecol 107:1247-51. 2006
    To determine whether a history of childhood dysfunctional voiding is associated with urinary incontinence in adulthood.
  36. ncbi Impact of vaginal surgery on sexuality and quality of life in women with urinary incontinence or genital descensus
    Lotti Helström
    Department of Women and Child Health, Karolinska Hospital, Stockholm, Sweden
    Acta Obstet Gynecol Scand 84:79-84. 2005
    To study the effect of vaginal surgery for urinary incontinence and genital descensus on sexual function and quality of life.
  37. ncbi Transurethral ultrasonography-guided injection of adult autologous stem cells versus transurethral endoscopic injection of collagen in treatment of urinary incontinence
    H Strasser
    Department of Urology, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    World J Urol 25:385-92. 2007
    ..The present clinical results demonstrate that, in contrast to injections of collagen, urinary incontinence can be treated effectively with ultrasonography-guided injections of autologous myo- and fibroblasts.
  38. ncbi Factors influencing the outcome of mid urethral sling procedures for female urinary incontinence
    Jae Seung Paick
    Department of Urology, Seoul National University Hospital, Seoul, Korea
    J Urol 178:985-9; discussion 989. 2007
    We evaluated the outcome at least 6 months after the tension-free vaginal tape or transobturator tape procedure in women with urinary incontinence, and identified factors predicting persistent stress urinary incontinence.
  39. ncbi Preoperative biofeedback assisted behavioral training to decrease post-prostatectomy incontinence: a randomized, controlled trial
    Kathryn L Burgio
    Birmingham Atlanta Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Birmingham, Alabama, USA
    J Urol 175:196-201; discussion 201. 2006
    ..We tested the effectiveness of preoperative biofeedback assisted behavioral training for decreasing the duration and severity of incontinence, and improving quality of life in the 6 months following radical prostatectomy...
  40. ncbi Falls in outpatients with Parkinson's disease: frequency, impact and identifying factors
    Y Balash
    Movement Disorders Unit, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv 64239, Israel
    J Neurol 252:1310-5. 2005
    ..by the Hoehn and Yahr Scale (H&Y), co-morbidities, the presence of depressive symptoms, the presence of urinary incontinence, use of anti-parkinsonian medications, and two performance-based tests of balance and gait (tandem standing ..
  41. ncbi An epidemiological survey of overactive bladder symptoms in Japan
    Yukio Homma
    Department of Urology, Japan Red Cross Medical Center, Tokyo, Japan
    BJU Int 96:1314-8. 2005
    ....
  42. ncbi Restoration of posterior aspect of rhabdosphincter shortens continence time after radical retropubic prostatectomy
    F Rocco
    Clinica Urologica I, Universita degli Studi, Fondazione Ospedale Maggiore Policlinico, Mangiagalli Regina Elena Ricovero e Cura a Carattere Scientifico, Milano, Italy
    J Urol 175:2201-6. 2006
    ..nonnerve sparing surgery and postoperative sphincter insufficiency can cause temporary or definitive urinary incontinence. We believe that sphincter deficiency is the main cause of early incontinence...
  43. pmc Localization of brain white matter hyperintensities and urinary incontinence in community-dwelling older adults
    George A Kuchel
    UConn Center on Aging, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 5215, USA
    J Gerontol A Biol Sci Med Sci 64:902-9. 2009
    ..WMHs) on magnetic resonance imaging (MRI) may be linked to geriatric syndromes involving mobility, cognition, and affect, we postulated that involvement of areas critical to bladder control could influence urinary incontinence (UI).
  44. ncbi Myoblast and fibroblast therapy for post-prostatectomy urinary incontinence: 1-year followup of 63 patients
    Michael Mitterberger
    Department of Urology, Innsbruck Medical University, Innsbruck, Austria
    J Urol 179:226-31. 2008
    We assessed the efficacy and safety of the application of autologous fibroblasts and myoblasts for treatment in post-prostatectomy urinary incontinence after a minimal followup of 1 year.
  45. ncbi Functional incidental training: a randomized, controlled, crossover trial in Veterans Affairs nursing homes
    Joseph G Ouslander
    Division of Geriatric Medicine and Gerontology, Department of Medicine, and the Center for Health in Aging, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    J Am Geriatr Soc 53:1091-100. 2005
    ..To test the effects of a rehabilitative intervention directed at continence, mobility, endurance, and strength (Functional Incidental Training (FIT)) in older patients in Department of Veterans Affairs (VA) nursing homes...
  46. ncbi Transobturator sling suspension for male urinary incontinence including post-radical prostatectomy
    Peter Rehder
    Department of Urology, Medical University Innsbruck, Austria
    Eur Urol 52:860-6. 2007
    To study the anatomical effects of placing a transobturator tape (TOT) in cadavers as well as determining the clinical outcome in men with urinary incontinence.
  47. ncbi Pessary test to predict postoperative urinary incontinence in women undergoing hysterectomy for prolapse
    Ching Chung Liang
    Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center, 5 Fu Shin Street, Kweishan, Taoyuan, Taiwan, ROC 333
    Obstet Gynecol 104:795-800. 2004
    We sought to demonstrate that a positive pessary test could predict postsurgical stress urinary incontinence in women with severe pelvic organ prolapse and that performing tension-free vaginal taping (TVT) could effectively prevent its ..
  48. ncbi Evaluation of parturition and other reproductive variables as risk factors for urinary incontinence in later life
    D H Thom
    Department of Medicine, Stanford University School of Medicine, Palo Alto, California, USA
    Obstet Gynecol 90:983-9. 1997
    To assess specific parturition and reproductive variables as potential risk factors for urinary incontinence in later life.
  49. ncbi 5-year urinary and sexual outcomes after radical prostatectomy: results from the prostate cancer outcomes study
    David F Penson
    Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    J Urol 173:1701-5. 2005
    ..In this study we assessed temporal changes in urinary and sexual function up to 5 years following radical prostatectomy in a population based cohort...
  50. pmc Refractory idiopathic urge urinary incontinence and botulinum A injection
    Linda Brubaker
    Department of Obstetrics and Gynecology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Urol 180:217-22. 2008
    ..We compared 200 U intradetrusor botulinum toxin A vs placebo in women with refractory idiopathic urge incontinence...
  51. ncbi Comprehensive comparison of health-related quality of life after contemporary therapies for localized prostate cancer
    John T Wei
    Veterans Affairs Center for Practice Management and Outcomes Research, Ann Arbor Veterans Affairs Medical Center, USA
    J Clin Oncol 20:557-66. 2002
    ..HRQOL effects of hormonal adjuvants and of cancer control after therapy also lack prior characterization...
  52. ncbi Influence of modified posterior reconstruction of the rhabdosphincter on early recovery of continence and anastomotic leakage rates after robot-assisted radical prostatectomy
    Rafael F Coelho
    Global Robotics Institute, Florida Hospital Celebration Health, Celebration, FL, USA
    Eur Urol 59:72-80. 2011
    ..This technique has also been applied during robot-assisted radical prostatectomy (RARP); however, contradictory results have been reported...
  53. ncbi Factors determining functional outcomes after radical prostatectomy: robot-assisted versus retropubic
    Seong Cheol Kim
    Department of Urology, Inje University, Haeundae Paik Hospital, Busan, Korea
    Eur Urol 60:413-9. 2011
    ..Early studies reported comparative results of functional outcomes between robot-assisted (RARP) and retropubic radical prostatectomy (RRP). However, well-controlled single-surgeon prospective studies comparing the outcomes are rare...
  54. ncbi Natural history and effects on 2-year outcomes of urinary incontinence after stroke
    M Patel
    Department of Public Health Medicine, Guy s, Kings, and St Thomas School of Medicine, King s College, London, England
    Stroke 32:122-7. 2001
    ..We sought to describe the natural history of poststroke incontinence and estimate its effect on survival and 2-year outcomes in stroke survivors...
  55. ncbi Indwelling urethral catheter and mortality in frail elderly women living in community
    Francesco Landi
    Department of Gerontology Geriatric and Physiatric, Catholic University of Sacred Heart, Rome, Italy
    Neurourol Urodyn 23:697-701. 2004
    b>Urinary incontinence is one of the most common, disruptive and often disabling conditions affecting frail older people living in community...
  56. ncbi A study of quality of life in primigravidae with urinary incontinence
    Lucia M Dolan
    Urogynaecology Subspecialty Trainee, Directorate of Women s Services, Royal Victoria Infirmary, NE1 4LP, Newcastle upon Tyne, UK
    Int Urogynecol J Pelvic Floor Dysfunct 15:160-4. 2004
    This study aimed to establish the prevalence and effect of urinary incontinence on quality of life during pregnancy and after parturition. A prospective cohort of primigravidae was recruited...
  57. ncbi The epidemiology of urinary incontinence and it's influence on quality of life in Taiwanese middle-aged women
    Shiow Shiun Horng
    Department of Public Health, National Yang Ming University, Taipei, Taiwan
    Neurourol Urodyn 32:371-6. 2013
    To evaluate the prevalence and risk factors of urinary incontinence (UI) and its effects on quality of life in women aged between 35 and 64 years.
  58. pmc Quantifying the natural history of post-radical prostatectomy incontinence using objective pad test data
    Anna R Smither
    Louisiana Urology, LLC, Baton Rouge, LA, USA
    BMC Urol 7:2. 2007
    b>Urinary incontinence (UI) following radical prostatectomy is a well-recognized risk of the surgery. In most patients post-operative UI improves over time...
  59. ncbi EAU guidelines on assessment and nonsurgical management of urinary incontinence
    Malcolm G Lucas
    Department of Urology, Morriston Hospital, Swansea, UK
    Eur Urol 62:1130-42. 2012
    The previous European Association of Urology (EAU) guidelines on urinary incontinence comprised a summary of sections of the 2009 International Consultation on Incontinence...
  60. ncbi Urinary incontinence in the elderly: attitudes and experiences of general practitioners. A focus group study
    Doreth Teunissen
    Department of General Practice, Radboud University Nijmegen Medical Centre, The Netherlands
    Scand J Prim Health Care 24:56-61. 2006
    To assess general practitioners' (GPs') attitudes to urinary incontinence in elderly patients and their experiences in the application of the Dutch College of General Practitioners' guideline in daily practice.
  61. pmc The sensitivity and specificity of a simple test to distinguish between urge and stress urinary incontinence
    Jeanette S Brown
    University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, San Francisco, California 94115, USA
    Ann Intern Med 144:715-23. 2006
    b>Urinary incontinence is common in women. Because treatments differ, urge incontinence should be distinguished from stress incontinence...
  62. ncbi Post stroke urinary loss, incontinence and life satisfaction: when does post-stroke urinary loss become incontinence?
    Dorothy F Edwards
    Program in Occupational Therapy, Washington University, St Louis, Missouri 63108, USA
    Neurourol Urodyn 25:39-45. 2006
    While urinary incontinence (UI) has been extensively studied after stroke, the threshold for when it becomes a social problem by affecting life satisfaction or social participation has not been established...
  63. pmc Antihypertensive drug class use and differential risk of urinary incontinence in community-dwelling older women
    Emily P Peron
    Department of Pharmacotherapy and Outcomes Science, School of Pharmacy, Virginia Commonwealth University, 410 North 12th Street, P O Box 980533, Richmond, VA 23298, USA
    J Gerontol A Biol Sci Med Sci 67:1373-8. 2012
    Medication use is a potentially reversible cause of urinary incontinence (UI)...
  64. ncbi Functional impairment as a risk factor for urinary incontinence among older Americans
    Kristi Rahrig Jenkins
    University of Michigan, Institute for Social Research, Ann Arbor, Michigan 48106, USA
    Neurourol Urodyn 24:51-5. 2005
    Using a large nationally representative sample of older Americans we investigate four domains of functional impairment as possible risk factors for the subsequent development of urinary incontinence (UI) symptoms.
  65. ncbi The effects of antimuscarinic treatments in overactive bladder: a systematic review and meta-analysis
    Christopher Chapple
    Sheffield Teaching Hospitals NHS Trust, Royal Hallamshire Hospital, Urology Research, J Floor Office, Glossop Road, Sheffield, S102JF, UK
    Eur Urol 48:5-26. 2005
    ..To evaluate the tolerability, safety and efficacy of antimuscarinic drugs used to treat overactive bladder and to identify any differences between individual antimuscarinics...
  66. ncbi Persistence with overactive bladder pharmacotherapy in a Medicaid population
    Fadia T Shaya
    Center on Drugs and Public Policy, University of Maryland School of Pharmacy, Baltimore, USA
    Am J Manag Care 11:S121-9. 2005
    ....
  67. ncbi Long-term functional and oncological results after retroperitoneal laparoscopic prostatectomy according to a prospective evaluation of 550 patients
    L Goeman
    Department of Urology, Henri Mondor Hospital, 51 Avenue du Ml de Lattre de Tassigny, 94010, Creteil, France
    World J Urol 24:281-8. 2006
    ..6% when the patients were younger than 60 years. LRP is now a standardised procedure. An extraperitoneal approach combines the advantages of a laparoscopic procedure with those of an extraperitoneal approach...
  68. ncbi Adherence to professional guidelines for patients with urinary incontinence by general practitioners: a cross-sectional study
    Pytha Albers-Heitner
    Integrated Care Unit, University Hospital Maastricht, Maastricht, The Netherlands
    J Eval Clin Pract 14:807-11. 2008
    b>Urinary incontinence is a common problem, affecting quality of life and leading to high costs. There is doubt about the use of clinical practice guidelines on urinary incontinence in primary care.
  69. pmc Caffeine and urinary incontinence in US women
    Jonathan L Gleason
    Department of Obstetrics and Gynecology, Division of Urogynecology and Pelvic Reconstructive Surgery, University of Alabama at Birmingham, 1700 6th Avenue South, Suite 10382, Birmingham, AL 35233, USA
    Int Urogynecol J 24:295-302. 2013
    The goal of this study was to characterize associations between caffeine consumption and severity of urinary incontinence (UI) in US women...
  70. ncbi The standardisation of terminology in lower urinary tract function: report from the standardisation sub-committee of the International Continence Society
    Paul Abrams
    Bristol Urological Institute, Bristol, United Kingdom
    Urology 61:37-49. 2003
  71. pmc Weight loss prevents urinary incontinence in women with type 2 diabetes: results from the Look AHEAD trial
    Suzanne Phelan
    Kinesiology Department, California Polytechnic State University, San Luis Obispo, California 93407 0386, USA
    J Urol 187:939-44. 2012
    ..determined the effect of weight loss on the prevalence, incidence and resolution of weekly or more frequent urinary incontinence in overweight/obese women with type 2 diabetes after 1 year of intervention in the Look AHEAD (Action for ..
  72. ncbi Impact of urinary incontinence after stroke: results from a prospective population-based stroke register
    Peter L Kolominsky-Rabas
    Department of Neurology, University of Erlangen Nuremberg, Erlangen, Germany
    Neurourol Urodyn 22:322-7. 2003
    The purpose of this study was to investigate, in a community-based population, the frequency of stroke-related urinary incontinence (UI) and to analyse the long-term impact of UI on prognosis and institutional care.
  73. ncbi Single-incision mini-slings versus standard midurethral slings in surgical management of female stress urinary incontinence: a meta-analysis of effectiveness and complications
    Mohamed Abdel-Fattah
    Division of Applied Health Sciences, University of Aberdeen, Aberdeen, UK
    Eur Urol 60:468-80. 2011
    Single-incision mini-slings (SIMS) have been introduced for the treatment of female stress urinary incontinence (SUI); however, concerns have been raised regarding their efficacy...
  74. ncbi Urinary incontinence, overactive bladder, and other lower urinary tract symptoms: a longitudinal population-based survey in men aged 45-103 years
    Ulf G H Malmsten
    Department of Geriatric Medicine, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden
    Eur Urol 58:149-56. 2010
    Lower urinary tract symptoms (LUTS) such as urinary incontinence (UI) and overactive bladder (OAB) are highly prevalent conditions, but there are few studies describing progression and remission of LUTS in men, especially over the long ..
  75. ncbi Continence definition after radical prostatectomy using urinary quality of life: evaluation of patient reported validated questionnaires
    Michael A Liss
    Department of Urology and Medicine, University of California Irvine, Orange, California, USA
    J Urol 183:1464-8. 2010
    ..We evaluated the association of pad status and urinary quality of life to determine whether security and 1 pad status differ from pad-free status to better define 0 pads as the post-prostatectomy standard...
  76. ncbi Prevalence and risk factors of urinary incontinence in young and middle-aged women
    L Peyrat
    Department of Urology, CHU Tenon, France
    BJU Int 89:61-6. 2002
    Objective To assess the prevalence of and risk factors for urinary incontinence (UI) in young and middle-aged women...
  77. ncbi Epidemiology and healthcare utilization of neurogenic bladder patients in a US claims database
    Aubrey Manack
    Allergan, Inc, Irvine, California, USA
    Neurourol Urodyn 30:395-401. 2011
    ..To characterize the patient profile, medication utilization, and healthcare encounters of patients with neurogenic bladder dysfunction related to incontinence...
  78. pmc Urinary incontinence in Canada. National survey of family physicians' knowledge, attitudes, and practices
    J Graham Swanson
    Department of Family Medicine, McMaster University, Hamilton, Ont
    Can Fam Physician 48:86-92. 2002
    To determine current knowledge, attitudes, and management of urinary incontinence among family physicians in Canada.
  79. ncbi Prostate cancer and urinary incontinence
    Brian A Parsons
    Department of Urology, Bristol Royal Infirmary, Bristol, United Kingdom
    Maturitas 63:323-8. 2009
    ..b>Urinary incontinence is uncommon in healthy men, but may develop as a result of curative treatment for prostate cancer...
  80. ncbi An easy prediction of urinary incontinence duration after retropubic radical prostatectomy based on urine loss the first day after catheter withdrawal
    M van Kampen
    Department of Rehabilitation Science Faculty of Kinesiology and Rehabilitation Science, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    J Urol 181:2641-6. 2009
    We sought to predict the duration of urinary incontinence after radical prostatectomy based on potential risk factors.
  81. ncbi A longitudinal population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in women
    Anna Lena Wennberg
    Department of Obstetrics and Gynaecology, Sahlgrenska Academy at Gothenburg University and Sahlgrenska University Hospital, Gothenburg, Sweden
    Eur Urol 55:783-91. 2009
    Female urinary incontinence (UI), overactive bladder (OAB), and other lower urinary tract symptoms (LUTS) are highly prevalent conditions with a profound influence on well-being and quality of life...
  82. pmc The burden of urinary incontinence and urinary bother among elderly prostate cancer survivors
    Ryan P Kopp
    Division of Urologic Oncology, UC San Diego Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093 0987, USA
    Eur Urol 64:672-9. 2013
    ..Data describing urinary health in elderly, community-dwelling prostate cancer (PCa) survivors are limited...
  83. ncbi Quality-of-life impact of primary treatments for localized prostate cancer in patients without hormonal treatment
    Yolanda Pardo
    Institut Municipal d Investigacions Mèdiques Hospital del Mar, Barcelona, Bellaterra, Spain
    J Clin Oncol 28:4687-96. 2010
    ..Our objective was to compare the QoL impact of the three most common primary treatments on patients who were not receiving adjuvant hormonal treatment...
  84. ncbi Sphincter lesions after radical prostatectomy-evaluation and classification
    Holger Gerullis
    Department of Urology, Lukas Hospital, Neuss, Germany
    J Endourol 25:1075-80. 2011
    ..The aim of this study was to analyze the sphincteric/perisphincteric lesions and modifications in incontinent patients with iatrogenic damage to the external urethral sphincter after radical prostatectomy (RP)...
  85. ncbi Prevalence of postpartum urinary incontinence: a systematic review
    David H Thom
    Department of Family and Community Medicine, University of California, San Francisco, USA
    Acta Obstet Gynecol Scand 89:1511-22. 2010
    to investigate the prevalence of urinary incontinence within the first year postpartum.
  86. ncbi Urinary incontinence following surgery for BPH: the role of aging on the incidence of bladder dysfunction
    Homero Bruschini
    Division of Urology, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Int Braz J Urol 37:380-6; discussion 387. 2011
    The reported incidence of urinary incontinence (UI) due to bladder dysfunction following surgery of BPH is variable...
  87. ncbi The prevalence and factors associated with previous surgery for pelvic organ prolapse and/or urinary incontinence in a cross-sectional study in The Netherlands
    T A de Boer
    Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, The Netherlands
    Eur J Obstet Gynecol Reprod Biol 158:343-9. 2011
    ..To estimate the prevalence and identify the factors associated with previous pelvic organ prolapse (POP) and/or incontinence surgery...
  88. ncbi Treatment of post-prostate surgery urinary incontinence with the periurethral constrictor: a retrospective analysis
    João Luiz Schiavini
    Department of Urology, Pedro Ernesto University Hospital HUPE, Rio de Janeiro State University, Rio de Janeiro, Brazil
    Urology 75:1488-92. 2010
    ..we present safety and efficacy data for a surgical alternative for the treatment of postprostate surgery urinary incontinence, based on the use of the periurethral constrictor, a two-part device--constrictor cuff and self-sealing ..
  89. ncbi The prevalence of urinary incontinence among community dwelling men: results from the National Health and Nutrition Examination survey
    Jennifer T Anger
    Department of Urology, David Geffen School of Medicine and School of Public Health, University of California, Los Angeles, Los Angeles 90095 1738, USA
    J Urol 176:2103-8; discussion 2108. 2006
    To measure the prevalence of urinary incontinence in community dwelling men in the United States, we analyzed data from respondents to the National Health and Nutrition Examination Survey.
  90. ncbi Prevalence, treatment and known risk factors of urinary incontinence and overactive bladder in the non-institutionalized Portuguese population
    Sofia Correia
    Department of Hygiene and Epidemiology, University of Porto Medical School, Porto, Portugal
    Int Urogynecol J Pelvic Floor Dysfunct 20:1481-9. 2009
    To quantify the prevalence (previous month) of urinary incontinence (UI) and overactive bladder (OAB), to assess its relation with known risk factors and to characterize UI awareness and treatment.
  91. ncbi Quality of life and continence in patients with spina bifida
    J L Lemelle
    Service de Chirurgie Infantile, Hôpital d Enfants, CHU de Nancy, Vandoeuvre les Nancy, France
    Qual Life Res 15:1481-92. 2006
    ..This study attempts to determine the relationships between urinary/faecal incontinence, methods of management, and Health Related Quality of Life (HRQoL) in people with SB...
  92. ncbi Treatment of neurogenic male urinary incontinence related to intrinsic sphincter insufficiency with an artificial urinary sphincter: a French retrospective multicentre study
    Emmanuel Chartier Kastler
    Service d Urologie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Paris VI, Paris, France
    BJU Int 107:426-32. 2011
    ..To assess results and morbidity of the periprostatic insertion of an artificial urinary sphincter (AUS) in adult male patients with a neurogenic bladder...
  93. ncbi Relationship of urinary incontinence and late-life disability: implications for clinical work and research in geriatrics
    Laura Coll-Planas
    Institute on Aging of the Universitat Autònoma de Barcelona UAB C, Sant Antoni Maria Claret, 171, 08041, Barcelona, Spain
    Z Gerontol Geriatr 41:283-90. 2008
    The role of urinary incontinence (UI) in the disablement process model has been mainly defined according to its impact on quality of life, global wellbeing, life satisfaction, institutionalization and death, which are global outcomes of ..
  94. pmc Measuring the barriers against seeking consultation for urinary incontinence among Middle Eastern women
    Ahmed S El-Azab
    Department of Urology, Section of Female Urology and Neurourology Assiut University Hospital, Assiut University, Assiut, Egypt
    BMC Womens Health 10:3. 2010
    Existing questionnaires to assess barriers against consultation for urinary incontinence (UI) are not appropriate for use in the Middle East culture...
  95. ncbi Safety and tolerability of extended-release oxybutynin once daily in urinary incontinence: combined results from two phase 4 controlled clinical trials
    Robert B Armstrong
    Ortho McNeil Neurologics, Inc, 1125 Trenton Harbourton Road, Titusville, NJ 08560 0200, USA
    Int Urol Nephrol 39:1069-77. 2007
    ..In total, 1.2, 1.0, and 1.6% of patients in the extended-release oxybutynin, extended-release tolterodine, and immediate-release tolterodine groups, respectively, discontinued study medication due to dry mouth...
  96. ncbi Fecal and urinary incontinence in primiparous women
    Diane Borello-France
    Duquesne University, Department of Physical Therapy, Pittsburgh, Pennsylvania 15282, USA
    Obstet Gynecol 108:863-72. 2006
    To prospectively investigate the relationship between anal sphincter tears and postpartum fecal and urinary incontinence.
  97. ncbi Pelvic floor muscle training during pregnancy to prevent urinary incontinence: a single-blind randomized controlled trial
    Siv Mørkved
    Department of Community Medicine and General Practice, Norwegian University of Science and Technology, Trondheim, Norway
    Obstet Gynecol 101:313-9. 2003
    b>Urinary incontinence is a chronic health complaint that severely reduces quality of life. Pregnancy and vaginal delivery are main risk factors in the development of urinary incontinence...
  98. ncbi Pentafecta: a new concept for reporting outcomes of robot-assisted laparoscopic radical prostatectomy
    Vipul R Patel
    Global Robotics Institute, Florida Hospital Celebration Health, University of Central Florida School of Medicine, Orlando, FL 34747, USA
    Eur Urol 59:702-7. 2011
    ..Their demands and expectations of surgical intervention are much higher and cannot be adequately addressed with the classic trifecta outcome measures...
  99. ncbi Predictors of institutionalization in elderly people living at home: the impact of incontinence and commode use in rural Japan
    Masatoshi Matsumoto
    Division of Community and Family Medicine, Centre for Community Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    J Cross Cult Gerontol 22:421-32. 2007
    ..In conclusion, incontinence is a predictor for institutionalization in elderly men. Use of a commode, however, does not appear to have a preventive effect with respect to institutionalization in elderly men...
  100. ncbi European experience of 200 cases treated with botulinum-A toxin injections into the detrusor muscle for urinary incontinence due to neurogenic detrusor overactivity
    Andre Reitz
    Neuro Urology, Swiss Paraplegic Center, Balgrist University Hospital, Forchstrasse 340, 8008, Zurich, Switzerland
    Eur Urol 45:510-5. 2004
    ..To present a comprehensive experience with botulinum-A toxin (BTA) injected into the detrusor muscle in patients with spinal cord injuries/diseases causing neurogenic incontinence...
  101. ncbi Urinary incontinence in women
    Donna Y Deng
    Department of Urology, University of California San Francisco, 400 Parnassus Avenue A633, Box 0738, San Francisco, CA 94143 0738, USA
    Med Clin North Am 95:101-9. 2011
    b>Urinary incontinence is a common and vexing problem that affects millions of adults. The main types of incontinence in women are stress, urge, and mixed...

Research Grants79

  1. Iowa Pelvic Floor Disorders Clinical Trials Network
    Karl Kreder; Fiscal Year: 2005
    Urge and mixed urinary incontinence are common conditions, affecting 10-20% of American women. While several treatment modalities exist, pharmacotherapy remains the mainstay of treatment...
  2. Targeted siRNA nanotechnology for intravesical treatment of urologicaldiseases
    Robert M Weiss; Fiscal Year: 2010
    ..Our first test of these nanoparticles will use a mouse model of bladder cancer. Thus, we can determine the therapeutic potential of siRNA for treatment of urologic diseases. ..
  3. Mechanism of Bladder Overactivity in Pelvic Ischemia
    Kazem M Azadzoi; Fiscal Year: 2013
    ..abstract_text> ..
  4. Stem Cell Homing for Treatment of Female Pelvic Floor Disorders
    Margot S Damaser; Fiscal Year: 2013
    ..S. experience female pelvic floor disorders (FPFD): stress urinary incontinence (SUI), fecal incontinence, and pelvic organ prolapse (POP)...
  5. Chronic Electrical Stimulation to Reduce Bladder Hyperreflexia after SCI
    Kenneth J Gustafson; Fiscal Year: 2012
    ..Neurogenic bladder can result in reflex bladder activity that can result in urinary incontinence, renal damage and autonomic dysreflexia...
  6. Effects of spinal cord injury on vagal afferents from the rat bladder and colon.
    April N Herrity; Fiscal Year: 2013
    ..Complications include overactivity of th detrusor muscle, leading to urinary incontinence, sustained high pressure within the bladder tissue walls and sphincter-detrusor dyssynergia, resulting in a ..
  7. Roles of RhoA/Rho-kinase Signaling in Cavernous Neurons Following Axonal Injury
    TRINITY JUDE BIVALACQUA; Fiscal Year: 2013
    ..b>Urinary incontinence following radical prostatectomy (RP) has been greatly reduced;however, neurogenic-ED following "nerve-..
  8. Robot-Assisted MRI-Guided Prostate Biopsy
    Dan Stoianovici; Fiscal Year: 2010
    ..Yet treatment is not a general solution because of adverse effects such as urinary incontinence and erectile dysfunction, and of potentially having a staggering impact on our healthcare system...
  9. Geriatric Conditions and Disablement in the Older Adult Population
    Christine T Cigolle; Fiscal Year: 2013
    ..The research will examine five geriatric conditions: dementia, falls, urinary incontinence, poor nutrition, and multisensory impairment...
  10. Implantation of physiologically functional bioengineered innervated IAS construct
    Khalil N Bitar; Fiscal Year: 2010
    ..Furthermore it would have positive implications for research focusing on people suffering from urinary incontinence. PUBLIC HEALTH RELEVANCE: This grant proposal represents an innovative approach that could result in ..
  11. Function and regulation of elemental Ca2+ signaling in urethral smooth muscle
    Ronghua Zhuge; Fiscal Year: 2013
    ..urethral myogenic and neurogenic tone, and their malfunction may result in urethral dysfunction and urinary incontinence. To test this central hypothesis we will employ an integrated approach using high-speed Ca2+ imaging with ..
  12. Role of Integrins in Bladder Urothelium
    Warren G Hill; Fiscal Year: 2013
    ..This project will provide new knowledge of the mechanisms by which the bladder senses filling and responds and in so doing may suggest new therapeutic options for bladder disease. ..
  13. Tissue recovery in the pathophysiology of stress urinary incontinence
    Adonis K Hijaz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Stress urinary incontinence (SUI) affects approximately 35% of women over the age of 40 and carries a large social, medical and personal burden...
  14. Visualization of Pelvic Floor Reflexes
    CHRISTOS EURIPIDES CONSTANTINOU; Fiscal Year: 2010
    Female urinary incontinence has been recently termed a "silent epidemic", requiring systematic attention and a multidisciplinary approach towards economically ameliorating its impact...
  15. Regenerative Adjuvant Therapy for Stress Urinary Incontinence
    Margot S Damaser; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Stress urinary incontinence (SUI) is the involuntary urine leakage on effort or exertion and is the most common form of urinary incontinence...
  16. Molecular mechanism of regulation of mI(CAT) in intestinal smooth muscle cells
    Michael X Zhu; Fiscal Year: 2012
    ..This will shed light on the pathogenesis and new treatment of a wide range of human diseases caused by smooth muscle dysfunctions, such as inflammatory bowel disease, irritable bowel syndrome, and urge incontinence. ..
  17. Stem cells for novel gene delivery of nitric oxide in the gut
    Hiroshi Mashimo; Fiscal Year: 2013
    ..range pathologies prevalent in our aging Veteran population such as spinal cord injuries, male impotence, urinary incontinence in which nitric oxide play a major role, and in a wide range of neuropathies resulting from diabetes and ..
  18. Pharmacology of Intravesical Antisense Based Therapy for Over Active Bladder
    Naoki Yoshimura; Fiscal Year: 2013
    ..The long-term objectives of the research program are to establish new and effective therapeutic targets and/or interventions strategies for the treatment of OAB. ..
  19. Mechanism of Type I and II Caused Diabetic Bladder Dysfunction
    Firouz Daneshgari; Fiscal Year: 2013
    ..and mechanisms of DBD, a range of abnormalities characterized mainly by poor emptying of the bladder and urinary incontinence, has been inadequate for development of effective treatments...
  20. Wireless Implantable Monitor for Improved Neuromodulation
    Margot S Damaser; Fiscal Year: 2012
    ..to be overcome for application of the pressure monitor to provide closed-loop control for prevention of urinary incontinence, including assessment of feasibility of implantation, optimization of the pressure monitor for chronic ..
  21. Determinants of Quality of Life in Elderly Adults with Diabetes
    Neda Laiteerapong; Fiscal Year: 2011
    ..the care of elderly diabetes patients should include screening and managing geriatric syndromes like falls, urinary incontinence, dementia, depression, chronic pain, and frailty...
  22. Mid Career Award in Patient Oriented Pelvic Floor Research
    Holly E Richter; Fiscal Year: 2013
    ..therapy and a randomized trial studying the utility of urodynamics in women undergoing surgery for stress urinary incontinence (funded through NICHD and NIDDK, U01 awards)...
  23. Risk Factors for Urinary Incontinence in Women
    Francine Grodstein; Fiscal Year: 2010
    ..provided by applicant): This is the final resubmission of a competing renewal to examine risk factors for urinary incontinence. Estimates in middle-aged and older women indicate that 30-40% have urinary incontinence (UI);in those over ..
  24. Improving Urinary Continence and Quality of Life in Prostate Cancer Patients
    Amy Y Zhang; Fiscal Year: 2012
    ..10-year survival in patients with prostate cancer - the most common cancer diagnosis in men - incidence of urinary incontinence (UI) resulting from radical prostatectomy is reported to be as high as 87%...
  25. Behavioral therapy to treat urinary symptoms in Parkinson's disease
    ELIZABETH CAMILLE VAUGHAN; Fiscal Year: 2012
    ..disease (PD) patients suffer from lower urinary tract symptoms (LUTS) including more than 25% who have urinary incontinence (UI)...
  26. NFAT and MEF-2 Choreograph Bladder Wall Remodeling Following Partial Outlet Obstr
    STEPHEN ANTHONY ZDERIC; Fiscal Year: 2010
    ..of this proposed work to human disease is apparent when one considers the socially devastating sequelae of urinary incontinence and renal failure that may result from untreated bladder wall hypertrophy...
  27. Molecular Dissection of Retinoic Acid Function in Leiomyoma Development
    WILLIAM HENRY CATHERINO; Fiscal Year: 2010
    ..a significant role in miscarriage, infertility, preterm labor, heavy menstrual periods, pelvic pain, and urinary incontinence. Despite such dramatic symptoms, the etiology of uterine leiomyomas is marginally understood...
  28. Pelvic Floor Disorders Network - Duke University Clinical Site
    Anthony G Visco; Fiscal Year: 2013
    ..investigators is fellowship-trained with expertise in both surgical and non-surgical management of urinary incontinence (Ul), pelvic organ prolapse (POP), fecal incontinence, and defecatory dysfunction...
  29. Multi-disciplinary Training in Benign Urology
    Hunter Wessells; Fiscal Year: 2013
    ..Collectively, congenital genitourinary anomalies, kidney stones, urinary incontinence, erectile dysfunction, lower urinary tract symptoms, benign prostatic hyperplasia, pelvic pain and urethral ..
  30. Nutritional Epidemiology of Lower Urinary Tract Symptoms
    Nancy Nairi Maserejian; Fiscal Year: 2010
    ..zinc, and LUTS, voiding symptoms, post micturition symptoms, and storage symptoms, including urgency and urinary incontinence, separately in men and women...
  31. Regeneration of the Lower Urinary Tract in Nonhuman Primates
    James Koudy Williams; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Urinary incontinence affects more than 200 million patients worldwide, and is associated with significant reduction in quality of life Current treatment options have limitations and options are needed...
  32. Mechanisms of Neurogenic Bladder Dysfunction in EAE Mice
    Firouz Daneshgari; Fiscal Year: 2010
    Neurogenic Urinary Incontinence (NUI) is the most bothersome manifestation of Neurogenic Bladder Dysfunction (NBD). NBD refers collectively to bladder dysfunctions that are caused by neurological problems such as multiple sclerosis (MS)...
  33. Architectural Design of the Pelvic Floor Skeletal Muscles
    Marianna Alperin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pelvic floor disorders (PFD) include pelvic organ prolapse (POP), urinary incontinence, and fecal incontinence...
  34. Dietary and serum phytoestrogens and women's health conditions in midlife
    Gail A Greendale; Fiscal Year: 2012
    ..and phytoestrogen metabolites and 4 outcomes: bone mineral density (BMD), vasomotor symptoms (VMS), urinary incontinence (UI) and cognitive performance...
  35. Roles for Serotonin in Autonomic Innervation of the Lower Urinary Tract
    KAREN ELAINE RITTER; Fiscal Year: 2013
    ..form of the 5-HT3A receptor gene, Htr3a vs/vs, display a hypertrophic bladder phenotype in conjunction with urinary incontinence. Finally, intriguing clinical data has shown profound success in treating stress and urge urinary ..
  36. Mechanism and Prevention of Female Stress Urinary Incontinence
    Tom F Lue; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Stress urinary incontinence affects millions of women in the United States and has substantial negative effects on quality of life...
  37. Fabrication and validation of implantable MRI markers for prostate cancer treatme
    Andrew Bright; Fiscal Year: 2010
    ..As a result, approximately 8-10% of men experience leakage of urine and urinary incontinence at 2 years after PB...
  38. Development of a Novel High-Throughput Screening Platform for BK Channel Modulato
    Frank T Horrigan; Fiscal Year: 2013
    ..paralysis, asthma, COPD, angina, arterial hypertension, ischemic heart disease, erectile dysfunction, urinary incontinence, gastric hypermotility, irritable bowel syndrome, pancreatitis, cancer (brain, bone, and prostate), ..
  39. Purinergic Regulation of Bladder Interstitial Cells of Cajal
    Weiqun Yu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Urinary incontinence, overactive bladder (OAB) and neurogenic bladder often arise from inappropriate bladder smooth muscle (BSM) motility and the underlying mechanisms are poorly understood...
  40. Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN)
    Karl J Kreder; Fiscal Year: 2013
    ..and urodynamically-defined LUTD, including detrusor overactivity with or without urge incontinence, stress urinary incontinence and obstruction...
  41. Children's Hospital Boston George O'Brien Urology Research Center
    Rosalyn M Adam; Fiscal Year: 2012
    ..in office-based settings there were 1,781,506 visits to pediatricians and family practitioners for which urinary incontinence was coded as any diagnosis for 1992-2000, a rate of 2,548 per 100,000 children...
  42. Bladder drug delivery using intravesical liposomes to treat overactive bladder
    JONATHAN H KAUFMAN; Fiscal Year: 2012
    ..With the support of the NIH, Lipella can become a sustainable tax paying company that improves the health care of Americans and supports the local and national economy. ..
  43. Ca2+ Sparks and Urinary Bladder Smooth Muscle Excitability
    Mark T Nelson; Fiscal Year: 2013
    A number of diseases and pathologies are associated with both urinary incontinence and erectile dysfunction (ED), including diabetes, benign prostate hyperplasia, hypertension, and hyperlipidemia...
  44. Patient-Reported Outcomes in Functioning for Female Pelvic Floor Disorders
    Vivian W Sung; Fiscal Year: 2013
    ..TOPIC: Female PFDs, including urinary incontinence, pelvic organ prolapse and fecal incontinence, are chronic conditions with a significant impact on multiple ..
  45. Longitudinal Impact of Antihypertensive Polypharmacy on Geriatric Syndromes
    Joseph T Hanlon; Fiscal Year: 2010
    ..Geriatric syndromes such as cognitive impairment, urinary incontinence and mobility problems/falls are also common, morbid and costly for older adults...
  46. Diabetic Uropathy Pathobiology Site
    Firouz Daneshgari; Fiscal Year: 2010
    ..Diabetic Uropathy is a term for a range of debilitating urologic complications such as bladder dysfunction, urinary incontinence, urinary tract infection and sexual dysfunction, that are among the most common and costly, yet ..
  47. Extra / Intra-cellular Signaling in Novel 3-Dimensional Human Leiomyoma Cultures
    WILLIAM HENRY CATHERINO; Fiscal Year: 2013
    ..leiomyoma play a significant role in miscarriage, infertility, preterm labor, menorrhagia, pelvic pain, and urinary incontinence. Despite such dramatic symptoms, the etiology of uterine leiomyomas is marginally understood...
  48. Molecular and Functional Mechanisms of Purinergic Relaxation in Detrusor Muscle
    Sang Don Koh; Fiscal Year: 2013
    ..This information will open up important novel areas of investigation in urodynamics physiology and expand new venue of treatment of bladder over activity. ..
  49. Decision Making For Active Surveillance in Prostate Cancer Patients and Spouses
    Christian J Nelson; Fiscal Year: 2013
    ..Given the potential for significant side-effects (e.g., erectile dysfunction, urinary incontinence, and bowl irritation) associated with treatment, AS is an important and viable alternative for patients ..
  50. Elastic Fiber Homeostasis in the Vaginal Wall
    Hiromi Yanagisawa; Fiscal Year: 2013
    ..Up to 11% of women have surgery for pelvic organ prolapse or urinary incontinence in their lifetime and more than 225,000 inpatient surgical procedures for pelvic organ prolapse are ..
  51. Regeneration of the Pelvic and Urethral Supports by Muscle Derived Stem Cells
    Matthew Ho; Fiscal Year: 2009
    ..pelvic muscles, such as levator ani, urethral supports and urethral sphincter, are responsible for stress urinary incontinence (SUI) in women...
  52. Core-Shell Fiber Mesh for the Treatment of UI and PFD in Elderly Women
    MICHAEL P H LAU; Fiscal Year: 2011
    ..PFDs including urinary incontinence (UI) affect one in three US women;left untreated they are a major trigger of fractures in the elderly and a ..
  53. Translating Unique Learning for Incontinence Prevention: The TULIP Project
    Janis M Miller; Fiscal Year: 2013
    ..More than one in three US women suffer from the distressing, embarrassing, and often unreported problem of urinary incontinence (UI)...
  54. Physical Activity and Pelvic Floor Disorders
    Ingrid E Nygaard; Fiscal Year: 2012
    ..how physical activity impacts pelvic floor disorders is important: half of American women have urinary incontinence or pelvic organ prolapse and one in nine undergoes surgery for these conditions...
  55. Licit Abused Drugs
    Roland R Griffiths; Fiscal Year: 2013
    ..by applicant): Caffeine use may cause or exacerbate anxiety, insomnia, panic attacks, hypertension, urinary incontinence, gastrointestinal disturbance, and problems in pregnancy...
  56. Smooth muscle plasticity: A COBRE
    Kenton M Sanders; Fiscal Year: 2013
    ..Kenton Sanders and Christine Cremo as PI and Co-PI, respectively. The PI and Co-PI are highly qualified, with many years of administrative and scientific experience in the thematic focus of the COBRE. ..
  57. QUALITY-OF-CARE INDICATORS FOR OVERACTIVE BLADDER SYMPTOMS
    Jennifer Tash Anger; Fiscal Year: 2011
    ..bladder (OAB) is defined by the International Continence Society as urinary urgency, with or without urge urinary incontinence, usually with frequency and nocturia...
  58. Developmental plasticity of micturation reflexes
    MARGARET ANN VIZZARD; Fiscal Year: 2012
    ..It is anticipated that these studies will provide insights into potential targets and therapeutic interventions for childhood and adult voiding dysfunctions. ..
  59. Brown/WIH Pelvic Floor Disorders Network Site
    Vivian W Sung; Fiscal Year: 2013
    ..a 3-stage, randomized trial of a combined non-surgical and surgical approach to treatment of mixed urinary incontinence (MUl) in women who have failed conservative therapy and/or elect surgical treatment...
  60. Effects of Practice Redesign on Falls Health Outcomes and Costs
    David B Reuben; Fiscal Year: 2012
    ..the ACOVE-2 Intervention to improve the quality of care that primary care physicians provide for falls and urinary incontinence. The ACOVE-2 practice redesign intervention includes 5 components: 1) case finding;2) efficient collection ..
  61. Is acupuncture a viable alternative to medication in overactive bladder for an el
    Ilana Addis; Fiscal Year: 2013
    ....
  62. Neural Crest Contributions to the Lower Urinary Tract
    E Michelle Southard-Smith; Fiscal Year: 2012
    ..are highly significant for understanding the etiology and potential treatments for neurogenic bladder and urinary incontinence. Spina bifida and spinal dysraphism are the most common causes of pediatric neurogenic bladder dysfunction...
  63. Cesarean and vaginal birth: cohort study of the impact on pelvic floor disorders
    VICTORIA LYNN HANDA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Despite the very high prevalence of female pelvic floor disorders (urinary incontinence, fecal incontinence, and pelvic organ prolapse), the biological mechanisms underlying these disorders are ..
  64. MOLECULAR AND BIOCHEMICAL STUDY OF COLLAGEN IN PROLAPSE
    Anthony Visco; Fiscal Year: 2002
    DESCRIPTION (Adapted from Applicant's Description): Pelvic floor dysfunction including urinary incontinence and pelvic organ prolapse is a major health issue for women resulting in an 11 percent lifetime risk of requiring surgery...
  65. Injectable, biocompatible poly (vinyl alcohol) hydrogels for tissue bulking
    Gavin Braithwaite; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Stress urinary incontinence (SUI) affects 13 million people in the United States per year [2], and some studies have suggested that at least 2% of healthcare costs result from urinary incontinence [3]...
  66. PRIDE: Program to Reduce Incontinence by Diet & Exercise
    Deborah Grady; Fiscal Year: 2007
    b>Urinary incontinence Is a commonproblem among women that causesdistress, diminished quality of life and dramatic limitations in daily functioning...
  67. NOVEL DRUGS TO TREAT URINARY INCONTINENCE
    JAN CHEN; Fiscal Year: 2009
    ..The new drug will greatly increase the quality of life of persons with OAB. ..
  68. NEUROPLASTICITY OF THE AGING BLADDER
    Toby Chai; Fiscal Year: 2000
    Voiding dysfunction in the elderly ranges from urinary incontinence to retention and causes significant morbidity. Even so, the current literature contains few data on the changes inflicted by age on the bladder and its function...
  69. Mechanisms of Female Urinary Incontinence in Diabetes
    Margot Damaser; Fiscal Year: 2006
    ..debilitating and devastating complications, including these of the lower urinary tract (LUT), such as urinary incontinence. Women with DM have a higher prevalence of LUT complications, contributing to the high prevalence of ..
  70. WHAT DAMAGE DOES VAGINAL BIRTH CAUSE
    John DeLancey; Fiscal Year: 2000
    ..of the pelvic floor that occurs at the time of birth is one of, if not the most important cause of stress urinary incontinence (SUI). Incontinent women have an odds ratio of 11...
  71. A 30-DAY INJECTION FOR TREATMENT OF URINARY INCONTINENCE
    ELIE NUWAYSER; Fiscal Year: 2001
    ..From a commercial standpoint, even a small penetration of this market would by itself represent an impressive business opportunity and ample return on investment. ..
  72. MUSCLE CELLS MEDIATED GENE THERAPY FOR INCONTINENCE
    Michael Chancellor; Fiscal Year: 2005
    b>Urinary incontinence is a major health care problem in the United States and an area of high priority for NIDDK...
  73. URINE LOSS AND PROLAPSE IN NUNS AND THEIR PAROUS SISTERS
    GUNHILDE BUCHSBAUM; Fiscal Year: 2003
    ..b>Urinary incontinence (UT) and pelvic organ prolapse (POP) are common health problems in older women, for which the etiologies ..
  74. A SYSTEM FOR MEASURING PELVIC MUSCLE STRENGTH IN WOMEN
    Neil Cole; Fiscal Year: 2000
    When stress urinary incontinence begins at a young age, often after giving vaginal birth, it initiates a lifelong problem...
  75. Novel Applications of Sarcomere Length to Improve Anal Continence
    RAVINDER MITTAL; Fiscal Year: 2009
    ..constitutes the fastest growing segment of VA health care users and pelvic floor disorders (fecal and urinary incontinence, pelvic organ prolapse) are extremely common in this patient population...
  76. Urinary Incontinence in Older Men Post Prostatectomy
    Joanne Robinson; Fiscal Year: 2006
    ..productive clinical investigator whose work focuses on design and testing of behavioral interventions for urinary incontinence (UI) in older men. Mentors for this award are Dr. Ruth McCorkle (Yale University School of Nursing) and Dr...
  77. ROLE OF BIOFEEDBACK IN TREATMENT OF URINARY INCONTINENCE
    Kathryn Burgio; Fiscal Year: 1999
    DESCRIPTION (adapted from the applicants abstract): Urinary incontinence in the elderly is a major problem with significant medical, psychological, and social consequences...
  78. Urinary Incontinence in Breast Cancer Survivors: A Controlled Comparsion
    KRISTINE ANNE DONOVAN; Fiscal Year: 2010
    ..b>Urinary incontinence (UI), or the involuntary leakage of urine, is a genitourinary symptom commonly associated with the ..
  79. URINARY INCONTINENCE--REPRODUCTIVE/HORMONAL RISK FACTORS
    David Thom; Fiscal Year: 2001
    ..determine the association between specific childbirth (parturition) events, hysterectomy, hormone use and urinary incontinence (UI) in later life...