acute kidney failure

Summary

Summary: A severe stage of acute renal insufficiency, characterized by the sudden decrease in GLOMERULAR FILTRATION RATE to less than 15 ml per min, sometime to less than 1 to 2 ml per min. It is usually associated with OLIGURIA; EDEMA; and increase in BLOOD UREA NITROGEN and serum CREATININE concentrations.

Top Publications

  1. ncbi Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
    Rinaldo Bellomo
    Department of Intensive Care and Medicine, Austin Health, Melbourne, Australia
    Crit Care 8:R204-12. 2004
  2. ncbi Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury
    Ravindra L Mehta
    Department of Medicine, University of California San Diego Medical Center 8342, 200 W, Arbor Drive, San Diego, CA 92103, USA
    Crit Care 11:R31. 2007
  3. ncbi Acute renal failure in patients with sepsis in a surgical ICU: predictive factors, incidence, comorbidity, and outcome
    Eric A J Hoste
    Intensive Care Unit and Renal Unit, Ghent University Hospital, Gent, Belgium
    J Am Soc Nephrol 14:1022-30. 2003
  4. ncbi Clinical review: RIFLE and AKIN--time for reappraisal
    Dinna N Cruz
    Department of Nephrology, Ospedale San Bortolo, Viale Rodolfi 37, 36100 Vicenza, Italy
    Crit Care 13:211. 2009
  5. ncbi Early hemofiltration improves survival in post-cardiotomy patients with acute renal failure
    Maqsood M Elahi
    Department of Cardiothoracic Surgery, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Eur J Cardiothorac Surg 26:1027-31. 2004
  6. ncbi Urinary neutrophil gelatinase-associated lipocalin (NGAL) as an early marker of acute kidney injury in critically ill multiple trauma patients
    Konstantinos Makris
    Clinical Biochemistry Department, KAT General Hospital, Kiffissia, Athens, Greece
    Clin Chem Lab Med 47:79-82. 2009
  7. ncbi Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock
    Derek S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Crit Care Med 36:1297-303. 2008
  8. ncbi Hemofiltration and peritoneal dialysis in infection-associated acute renal failure in Vietnam
    Nguyen Hoan Phu
    Center for Tropical Diseases, Center for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Vietnam
    N Engl J Med 347:895-902. 2002
  9. ncbi Incidence and outcomes of acute kidney injury in intensive care units: a Veterans Administration study
    Charuhas V Thakar
    Nephrology, Cincinnati VA Medical Center, Cincinnati, OH, USA
    Crit Care Med 37:2552-8. 2009
  10. ncbi Acute kidney injury in intensive care unit patients: a comparison between the RIFLE and the Acute Kidney Injury Network classifications
    José António Lopes
    Department of Nephrology and Renal Transplantation, Hospital de Santa Maria, Av, Prof, Egas Moniz, Lisboa 1649 035, Portugal
    Crit Care 12:R110. 2008

Research Grants

  1. Acute Kidney Failure in a Cancer ICU
    Joshua Samuels; Fiscal Year: 2007
  2. Identification of novel genes regulating metalloproteinase activity
    Andreas Herrlich; Fiscal Year: 2007
  3. Improving Kidney Transplant Outcome with a Novel Complement Inhibitor
    SHELLEY MAVES; Fiscal Year: 2007
  4. Structure Based design of Meprin A Inhibitors for Acute Nephropathy
    Kal Ramnarayan; Fiscal Year: 2007
  5. Epithelial/Dendritic Cell Cross-Talk in Acute Kidney Injury
    William Reeves; Fiscal Year: 2009
  6. Pathogenicity of Shiga Toxin-Producing E. coli
    ALISON O BRIEN; Fiscal Year: 2007
  7. Relative Roles of HSP70 and HSP25 in the Modulation of Renal Injury
    Rajasree Sreedharan; Fiscal Year: 2007
  8. PATHOGENICITY OF SHIGA TOXIN PRODUCING E COLI (STEC)
    ALISON O BRIEN; Fiscal Year: 2002
  9. CYTOPROTECTIVE ROLE OF HSP72 IN RENAL CELL INJURY
    Steven C Borkan; Fiscal Year: 2010
  10. Pathophysiology of sepsis-induced renal injury
    Pierre C Dagher; Fiscal Year: 2010

Detail Information

Publications248 found, 100 shown here

  1. ncbi Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
    Rinaldo Bellomo
    Department of Intensive Care and Medicine, Austin Health, Melbourne, Australia
    Crit Care 8:R204-12. 2004
    ..Accordingly, we sought to review the available evidence, make recommendations and delineate key questions for future studies...
  2. ncbi Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury
    Ravindra L Mehta
    Department of Medicine, University of California San Diego Medical Center 8342, 200 W, Arbor Drive, San Diego, CA 92103, USA
    Crit Care 11:R31. 2007
    ..We describe an initiative to develop uniform standards for defining and classifying AKI and to establish a forum for multidisciplinary interaction to improve care for patients with or at risk for AKI...
  3. ncbi Acute renal failure in patients with sepsis in a surgical ICU: predictive factors, incidence, comorbidity, and outcome
    Eric A J Hoste
    Intensive Care Unit and Renal Unit, Ghent University Hospital, Gent, Belgium
    J Am Soc Nephrol 14:1022-30. 2003
    ..This model allows initiating specific therapeutic measures earlier in the course of sepsis, hopefully resulting in a lower incidence of ARF and needi for RRT, thereby lowering mortality...
  4. ncbi Clinical review: RIFLE and AKIN--time for reappraisal
    Dinna N Cruz
    Department of Nephrology, Ospedale San Bortolo, Viale Rodolfi 37, 36100 Vicenza, Italy
    Crit Care 13:211. 2009
    ..As new data emerge, integration of novel biomarkers into the consensus definition will be a welcome refinement...
  5. ncbi Early hemofiltration improves survival in post-cardiotomy patients with acute renal failure
    Maqsood M Elahi
    Department of Cardiothoracic Surgery, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Eur J Cardiothorac Surg 26:1027-31. 2004
    ..The aim of the present study was to identify how the timing of introduction of hemofiltration affects the morbidity and mortality in patients with ARF after cardiac surgery...
  6. ncbi Urinary neutrophil gelatinase-associated lipocalin (NGAL) as an early marker of acute kidney injury in critically ill multiple trauma patients
    Konstantinos Makris
    Clinical Biochemistry Department, KAT General Hospital, Kiffissia, Athens, Greece
    Clin Chem Lab Med 47:79-82. 2009
    ..The aim of this study was to evaluate urinary NGAL levels as a predictor of early AKI (first 5 days after injury) in multi-trauma patients...
  7. ncbi Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock
    Derek S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Crit Care Med 36:1297-303. 2008
    ..To validate serum neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for acute kidney injury in critically ill children with septic shock...
  8. ncbi Hemofiltration and peritoneal dialysis in infection-associated acute renal failure in Vietnam
    Nguyen Hoan Phu
    Center for Tropical Diseases, Center for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Vietnam
    N Engl J Med 347:895-902. 2002
    ..CONCLUSIONS: Hemofiltration is superior to peritoneal dialysis in the treatment of infection-associated acute renal failure...
  9. ncbi Incidence and outcomes of acute kidney injury in intensive care units: a Veterans Administration study
    Charuhas V Thakar
    Nephrology, Cincinnati VA Medical Center, Cincinnati, OH, USA
    Crit Care Med 37:2552-8. 2009
    ..Acute kidney injury in intensive care unit patients is associated with significant mortality...
  10. ncbi Acute kidney injury in intensive care unit patients: a comparison between the RIFLE and the Acute Kidney Injury Network classifications
    José António Lopes
    Department of Nephrology and Renal Transplantation, Hospital de Santa Maria, Av, Prof, Egas Moniz, Lisboa 1649 035, Portugal
    Crit Care 12:R110. 2008
    ..We evaluated the incidence of acute kidney injury and compared the ability of the maximum RIFLE and of the maximum AKIN within intensive care unit hospitalization in predicting inhospital mortality of critically ill patients...
  11. ncbi Urinary IL-18 is an early predictive biomarker of acute kidney injury after cardiac surgery
    C R Parikh
    Section of Nephrology, Yale University, New Haven, Connecticut 06516, USA
    Kidney Int 70:199-203. 2006
    ..The combination of these two biomarkers may allow for the reliable early diagnosis and prognosis of AKI at all times after CPB, much before the rise in serum creatinine...
  12. ncbi Management of crush-related injuries after disasters
    Mehmet Sukru Sever
    Department of Internal Medicine, Istanbul School of Medicine, Istanbul, Turkey
    N Engl J Med 354:1052-63. 2006
  13. ncbi Acute kidney injury in patients with sepsis: a contemporary analysis
    José António Lopes
    Department of Nephrology and Renal Transplantation, Hospital de Santa Maria, Av Prof Egas Moniz, 1649 035, Lisbon, Portugal
    Int J Infect Dis 13:176-81. 2009
    ....
  14. ncbi Impact of minimal increases in serum creatinine on outcome in patients after cardiothoracic surgery: do we have to revise current definitions of acute renal failure?
    Andrea Lassnigg
    Department of Cardiothoracic and Vascular Anesthesia and Intensive Care Medicine, University Hospital of Vienna, A 1090 Vienna, Austria
    Crit Care Med 36:1129-37. 2008
    ....
  15. ncbi Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury
    Jaya Mishra
    Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA
    J Am Soc Nephrol 14:2534-43. 2003
    ..The results indicate that NGAL may represent an early, sensitive, noninvasive urinary biomarker for ischemic and nephrotoxic renal injury...
  16. ncbi Insulin resistance in critically ill patients with acute renal failure
    Seema Basi
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232-2372, USA
    Am J Physiol Renal Physiol 289:F259-64. 2005
    ..Insulin resistance as defined by hyperglycemia in the setting of higher insulin concentrations may be associated with mortality in critically ill patients with ARF. The IGF-IGFBP axis may play an important role in this process...
  17. ncbi Incidence, classification, and outcomes of acute kidney injury
    Eric A J Hoste
    Intensive Care Unit, Ghent University Hospital, Ghent, Belgium
    Contrib Nephrol 156:32-8. 2007
    ..Recent data emphasized the importance of less severe impairment of kidney function, hence the terminology acute kidney injury (AKI) was introduced...
  18. ncbi The local and systemic inflammatory transcriptome after acute kidney injury
    Dmitry N Grigoryev
    Division of Allergy and Clinical Immunology, 5501 Hopkins Bayview Circle, JHAAC 3A 62, Baltimore, Maryland, 21224, USA
    J Am Soc Nephrol 19:547-58. 2008
    ..Functional genomic analysis identified potential mediators that connect local and systemic inflammation, suggesting that this type of analysis may be a useful discovery tool for novel biomarkers and therapeutic drug development...
  19. ncbi Acute renal failure independently predicts mortality after myeloablative allogeneic hematopoietic cell transplant
    Chirag R Parikh
    Section of Nephrology, Yale University School of Medicine, New Haven, Connecticut 06473, USA
    Kidney Int 67:1999-2005. 2005
    ..Patients undergoing myeloablative allogeneic hematopoietic cell transplantation (HCT) have a high incidence of acute renal failure (ARF). However, it is unclear if ARF is independently associated with mortality after this procedure...
  20. ncbi The Prospective Pediatric Continuous Renal Replacement Therapy (ppCRRT) Registry: design, development and data assessed
    S L Goldstein
    Baylor College of Medicine, Houston, Texas, USA
    Int J Artif Organs 27:9-14. 2004
    ....
  21. ncbi Kidney dysfunction in the postoperative period
    J W Sear
    Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK
    Br J Anaesth 95:20-32. 2005
    ....
  22. ncbi Early renal replacement therapy in patients with postoperative acute liver failure associated with acute renal failure: effect on postoperative outcomes
    Vin Cent Wu
    Department of Internal Medicine, Yun Lin branch, National Taiwan University, Taipei, Taiwan
    J Am Coll Surg 205:266-76. 2007
    ..The optimal time to initiate renal replacement therapy for acute renal failure is controversial because of the poor overall clinical outcomes...
  23. ncbi Spectrum of acute renal failure in the intensive care unit: the PICARD experience
    Ravindra L Mehta
    Division of Nephrology, Department of Medicine, University of California San Diego, San Diego, California, USA
    Kidney Int 66:1613-21. 2004
    ..There is wide variation across institutions in patient characteristics and practice patterns. These differences highlight the need for additional multicenter observational and interventional studies in ARF...
  24. ncbi Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function
    D P Basile
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Renal Physiol 281:F887-99. 2001
    ..We hypothesize that severe ischemic injury results in a permanent alteration of renal capillary density, contributing to a urinary concentrating defect and the predisposition toward the development of renal fibrosis...
  25. ncbi Renal dysfunction and serious infections after open-heart surgery
    Charuhas V Thakar
    Department of Nephrology and Hypertension, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Kidney Int 64:239-46. 2003
    ..The infection rate was higher in patients with postoperative ARF regardless of the baseline renal function. However, preoperative renal dysfunction portended higher risk of infection, independent of the influence of postoperative ARF...
  26. ncbi Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery
    Jaya Mishra
    Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229-3039, USA
    Lancet 365:1231-8. 2005
    ..00, and specificity was 0.98 for a cutoff value of 50 microg/L. INTERPRETATION: Concentrations in urine and serum of NGAL represent sensitive, specific, and highly predictive early biomarkers for acute renal injury after cardiac surgery...
  27. ncbi The changing epidemiology of acute renal failure
    Norbert Lameire
    Ghent University, Ghent, Belgium
    Nat Clin Pract Nephrol 2:364-77. 2006
    ....
  28. ncbi Continuous renal replacement therapy: a worldwide practice survey. The beginning and ending supportive therapy for the kidney (B.E.S.T. kidney) investigators
    Shigehiko Uchino
    Jikei University School of Medicine, Intensive Care Unit, Department of Anesthesiology, Tokyo, Japan
    Intensive Care Med 33:1563-70. 2007
    ..Little information is available regarding current practice in continuous renal replacement therapy (CRRT) for the treatment of acute renal failure (ARF) and the possible clinical effect of practice variation...
  29. ncbi Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study
    Michael Bennett
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, OH 45229 3039, USA
    Clin J Am Soc Nephrol 3:665-73. 2008
    ..In this study, whether an NGAL immunoassay developed for a standardized clinical platform (ARCHITECT analyzer, Abbott Diagnostics Division, Abbott Laboratories, Abbott Park, IL) can predict AKI after CPB was tested...
  30. ncbi Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort study
    Catherine L Dent
    Department of Cardiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, 3333 Burnet Ave, Cincinnati, Ohio 45229, USA
    Crit Care 11:R127. 2007
    ..In this study we tested whether a point-of-care NGAL device can predict AKI after CPB in a larger cohort...
  31. ncbi Identification of persistently altered gene expression in the kidney after functional recovery from ischemic acute renal failure
    David P Basile
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Physiol Renal Physiol 288:F953-63. 2005
    ..In summary, genes with known inflammatory, remodeling, and vasoactive activities were identified in rat kidneys after recovery from ARF, some of which may play a role in altering long-term renal function after recovery from ARF...
  32. ncbi Plasma exchange when myeloma presents as acute renal failure: a randomized, controlled trial
    William F Clark
    University of Western Ontario, London, Ontario, Canada
    Ann Intern Med 143:777-84. 2005
    ..29 mL.s(-2).m(-2) (<30 mL/min per 1.73 m2) at 6 months...
  33. ncbi Acute renal failure
    Norbert Lameire
    Renal Division, Department of Medicine, University Hospital Ghent, De Pintelaan 185, 9000 Ghent, Belgium
    Lancet 365:417-30. 2005
    ..Finally, some information on the influence of gene polymorphisms on the prognosis of acute renal failure is given...
  34. ncbi Rifle classification for predicting in-hospital mortality in critically ill sepsis patients
    Yung Chang Chen
    Departments of Nephrology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    Shock 31:139-45. 2009
    ..In conclusion, these findings are consistent with a role for RIFLE classification in accurately predicting in-hospital mortality and short-term prognosis in ICU sepsis patients...
  35. ncbi Ischemic acute renal failure: an inflammatory disease?
    Joseph V Bonventre
    Medical Services, Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, and Harvard Massachusetts Institute of Technology, Division of Health Sciences and Technology, Charlestown, USA
    Kidney Int 66:480-5. 2004
    ..Understanding the inflammatory response prevalent in ischemic kidney injury will facilitate identification of molecular targets for therapeutic intervention...
  36. ncbi Timing of replacement therapy for acute renal failure after cardiac surgery
    Ufuk Demirkilic
    Cardiovascular Surgery Department, Etlik, Ankara, Turkey
    J Card Surg 19:17-20. 2004
    ..The aim of this study is to compare early and intensive use of continuous veno-venous hemodiafiltration (CVVHDF) with conservative usage of CVVHDF in patients with ARF after cardiac surgery...
  37. ncbi Influence of dialysis membranes on outcomes in acute renal failure: a meta-analysis
    Sanjay Subramanian
    Department of Medicine, Musselshell Medical Center, Roundup, Montana, USA
    Kidney Int 62:1819-23. 2002
    ..Finally, our results suggest that the survival disadvantage for cellulose-based membranes may be limited to unsubstituted cellulose (cuprophane) membranes...
  38. ncbi Global analysis of gene expression in renal ischemia-reperfusion in the mouse
    Takumi Yoshida
    Renal Division, Department of Medicine, Brigham and Women's Hospital, Cambridge, Massachusetts 02139, USA
    Biochem Biophys Res Commun 291:787-94. 2002
    ..Our data identified several novel genes that may be important in renal repair after ischemia...
  39. ncbi Biomarkers for the diagnosis and risk stratification of acute kidney injury: a systematic review
    S G Coca
    Clinical Epidemiology Research Center, Veterans Affairs Medical Center, West Haven, Connecticut 06516, USA
    Kidney Int 73:1008-16. 2008
    ..These biomarkers need validation in larger studies, and the generalizability of biomarkers to different types of AKI as well as the incremental prognostic value over traditional clinical variables needs to be determined...
  40. ncbi Clearance of ceftazidime during continuous venovenous haemofiltration in critically ill patients
    Friederike Traunmüller
    Department of Internal Medicine I, Division of Infectious Diseases, University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    J Antimicrob Chemother 49:129-34. 2002
    ..3 +/- 0.6 h, 32.1 +/- 7.9 mL/min, 36.4 +/- 6.4 L and 74.5 +/- 6.5%, respectively. Based on these pharmacokinetic parameters and that maximal killing is at 4 x MIC we recommend at least ceftazidime 2 g i.v. q8h...
  41. ncbi Phosphatemic control during acute renal failure: intermittent hemodialysis versus continuous hemodiafiltration
    H K Tan
    Department of Intensive Care, Austin and Repatriation Medical Centre, Melbourne, Victoria, Australia
    Int J Artif Organs 24:186-91. 2001
    ..3% vs. 5.6%; P<0.1) during CVVHDF CONCLUSIONS: Abnormal serum phosphate concentrations are frequent in ARF patients before and during renal replacement, however, normalization of phosphatemia is achieved more frequently with CVVHDF...
  42. ncbi A comparison of the RIFLE and AKIN criteria for acute kidney injury in critically ill patients
    Sean M Bagshaw
    Department of Intensive Care, Austin Hospital, Heidelberg, Victoria 3084, Australia
    Nephrol Dial Transplant 23:1569-74. 2008
    ..The Acute Kidney Injury Network (AKIN) group has recently proposed modifications to this system. It is currently unknown whether there are advantages between these criteria...
  43. ncbi Prognosis for long-term survival and renal recovery in critically ill patients with severe acute renal failure: a population-based study
    Sean M Bagshaw
    Department of Critical Care Medicine, Calgary Health Region, University of Calgary, Calgary, Alberta, Canada
    Crit Care 9:R700-9. 2005
    ..Severe acute renal failure (sARF) is associated with considerable morbidity, mortality and use of healthcare resources; however, its precise epidemiology and long-term outcomes have not been well described in a non-specified population...
  44. ncbi Acute renal failure in critically ill patients: a multinational, multicenter study
    Shigehiko Uchino
    Department of Intensive Care, Austin Hospital, Melbourne, Australia
    JAMA 294:813-8. 2005
    ..87; 95% CI, 1.07-3.28; P = .03). CONCLUSION: In this multinational study, the period prevalence of ARF requiring RRT in the ICU was between 5% and 6% and was associated with a high hospital mortality rate...
  45. ncbi Dialytic treatment of rhabdomyolysis-induced acute renal failure: our experience
    G Splendiani
    Surgery Department, Tor Vergata University, Rome, Italy
    Ren Fail 23:183-91. 2001
    ..Nevertheless, the final outcome may be very different between ICU- and NICU-patients, with a higher mortality rate in ICU-patients, suffering from MODS...
  46. ncbi Pathophysiology of septic acute kidney injury: what do we really know?
    Li Wan
    Department of Intensive Care, Austin Hospital, Melbourne, Australia
    Crit Care Med 36:S198-203. 2008
    ..If this were to happen, our therapeutic approaches would also be profoundly altered...
  47. ncbi Derivation and validation of a simplified predictive index for renal replacement therapy after cardiac surgery
    Duminda N Wijeysundera
    Department of Anesthesia, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada
    JAMA 297:1801-9. 2007
    ..A predictive index for renal replacement therapy (RRT; hemodialysis or continuous venovenous hemodiafiltration) after cardiac surgery may improve clinical decision making and research design...
  48. ncbi Elimination of organic anions in response to an early stage of renal ischemia-reperfusion in the rat: role of basolateral plasma membrane transporters and cortical renal blood flow
    Gisela Di Giusto
    Farmacologia, Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de Rosario, CONICET, Rosario, Argentina
    Pharmacology 81:127-36. 2008
    ....
  49. ncbi Urinary biomarkers in the early diagnosis of acute kidney injury
    W K Han
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 73:863-9. 2008
    ..Urinary MMP-9 was not a sensitive marker in the case-control study. Our results suggest that urinary biomarkers allow diagnosis of acute kidney injury earlier than a rise in serum creatinine...
  50. ncbi Diuretics and mortality in acute renal failure
    Shigehiko Uchino
    Department of Intensive Care, Austin and Repatriation Medical Centre, Melbourne, Australia
    Crit Care Med 32:1669-77. 2004
    ..There is full equipoise for a randomized controlled trial of diuretics in critically ill patients with renal dysfunction...
  51. ncbi Dialysis in acute kidney injury--more is not better
    Joseph V Bonventre
    N Engl J Med 359:82-4. 2008
  52. ncbi Mortality after acute renal failure: models for prognostic stratification and risk adjustment
    G M Chertow
    Department of Medicine Research, Division of Nephrology, University of California San Francisco, San Francisco, California, USA
    Kidney Int 70:1120-6. 2006
    ..By incorporating exposures over time, the discriminatory power of predictive models in ARF can be significantly improved...
  53. ncbi Intensive insulin therapy and pentastarch resuscitation in severe sepsis
    Frank M Brunkhorst
    Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University, Jena, Germany
    N Engl J Med 358:125-39. 2008
    ..The role of intensive insulin therapy in patients with severe sepsis is uncertain. Fluid resuscitation improves survival among patients with septic shock, but evidence is lacking to support the choice of either crystalloids or colloids...
  54. ncbi A clinical score to predict acute renal failure after cardiac surgery
    Charuhas V Thakar
    Department of Nephrology and Hypertension, Cleveland Clinic Foundation, Cincinnati, OH, USA
    J Am Soc Nephrol 16:162-8. 2005
    ..82; 95% CI 0.80 to 0.85; P = 0.39). In conclusion, a score is valid and accurate in predicting ARF after open-heart surgery; along with increasing its clinical utility, the score can help in planning future clinical trials of ARF...
  55. ncbi RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis
    Eric A J Hoste
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, Department of Critical Care Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    Crit Care 10:R73. 2006
    ....
  56. ncbi Costs and outcomes of acute kidney injury (AKI) following cardiac surgery
    Joseph F Dasta
    College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    Nephrol Dial Transplant 23:1970-4. 2008
    ..We determined costs, resource use and mortality rate of patients. We used the serum creatinine component of the RIFLE system to classify AKI...
  57. ncbi Survival and quality of life of patients requiring acute renal replacement therapy
    Annika Ahlström
    Intensive Care Unit, Division of Anesthesiology and Intensive Care Medicine, Department of Surgery, Helsinki University Central Hospital, Finland
    Intensive Care Med 31:1222-8. 2005
    ..To assess long-term survival and health-related quality of life in patients with acute renal failure...
  58. ncbi Nutritional management of acute renal failure
    Wilfred Druml
    Medical Department III, Division of Nephrology, Vienna General Hospital, Vienna, Austria
    J Ren Nutr 15:63-70. 2005
    ..Therefore, nutrition therapy must be more closely monitored in patients with ARF than with other diseases...
  59. ncbi Plasma cytokine levels predict mortality in patients with acute renal failure
    Edith M Simmons
    Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Kidney Int 65:1357-65. 2004
    ..Strategies to modulate inflammation must take into account the complex cytokine biology in patients with established ARF...
  60. ncbi Impact of burn size and initial serum albumin level on acute renal failure occurring in major burn
    Gheun Ho Kim
    Department of Internal Medicine, Hallym University College of Medicine, Kangwon Do, South Korea
    Am J Nephrol 23:55-60. 2003
    ..The severity of the burn is largely determined by the burn size, and severe burns are likely to cause enough loss of extracellular fluid and albumin from plasma volume to produce shock and hypoalbuminemia...
  61. ncbi Early detection of acute renal failure by serum cystatin C
    Stefan Herget-Rosenthal
    Department of Nephrology, Thoracic and Cardiovascular Surgery, University Hospital, Essen, Germany
    Kidney Int 66:1115-22. 2004
    ..However, serum creatinine, the standard marker to detect ARF, demonstrates major limitations. We prospectively evaluated whether serum cystatin C detected ARF earlier than serum creatinine...
  62. ncbi Acid-base status of critically ill patients with acute renal failure: analysis based on Stewart-Figge methodology
    Jens Rocktaeschel
    Department of Intensive Care and Department of Medicine, University of Melbourne, Australia
    Crit Care 7:R60. 2003
    ..This acidosis is the result of the balance between the acidifying effect of increased unmeasured anions and hyperphosphatemia and the lesser alkalinizing effect of hypoalbuminemia...
  63. ncbi Haemodialysis for the prevention of contrast-induced nephropathy: outcome of 31 patients with severely impaired renal function, comparison with patients at similar risk and review
    Wolfgang Huber
    Department of Internal Medicine II, Klinikum rechts der Isar, Technical University of Munich, Germany
    Invest Radiol 37:471-81. 2002
    ..To investigate whether haemodialysis prevents contrast-induced nephropathy (definition: increase of serum-creatinine of >or= 0.5 mg/dL within 7 days)...
  64. ncbi Thoracoabdominal aortic aneurysm repair: a prospective cohort study of 121 cases
    Claudio S Cina
    Division of Vascular Surgery, McMaster University, Hamilton, Ontario, Canada
    Ann Vasc Surg 16:631-8. 2002
    ..Long-term survival after elective TAAA repair is excellent...
  65. ncbi Postnatal renal function in preterm newborns: a role of diseases, drugs and therapeutic interventions
    Laura Cuzzolin
    Department of Medicine and Public Health Section of Pharmacology, University of Verona, Policlinico G B Rossi, 37134, Verona, Italy
    Pediatr Nephrol 21:931-8. 2006
    ..Our data confirm a multifactorial origin of acute renal impairment in newborns. It is of note that pharmacological treatment with NSAIDs during pregnancy may negatively influence neonatal renal function...
  66. ncbi Adding a dialysis dose to continuous hemofiltration increases survival in patients with acute renal failure
    P Saudan
    Nephrology Unit, University Hospitals of Geneva, Geneva, Switzerland
    Kidney Int 70:1312-7. 2006
    ..62) was not affected by the type of renal replacement therapy. These results suggest that increasing the dialysis dose especially for low molecular weight solutes confers a better survival in severely ill patients with ARF...
  67. ncbi [Chronic renal failure: when do patients need a nephrologist?]
    T Wieland
    Departement Medizin, Kantonsspital Chur
    Ther Umsch 59:105-9. 2002
    ..We extract some of the relevant data considering own data collected at the University Hospital of Berne (Inselspital), Switzerland...
  68. ncbi Acute renal failure in children: etiology, treatment and outcome
    Ihab Sakr Shaheen
    Children and Young People's Kidney Unit, Nottingham City Hospital, NHS Trust, United Kingdom
    Saudi J Kidney Dis Transpl 17:153-8. 2006
    ..Further prospective studies will be required to analyze the impact of early hemofiltration in such patients...
  69. ncbi Dosing intermittent haemodialysis in the intensive care unit patient with acute renal failure--estimation of urea removal and evidence for the regional blood flow model
    Nigel S Kanagasundaram
    Section of Dialysis and Extracorporeal Therapy, Department of Hypertension Nephrology, OH, USA
    Nephrol Dial Transplant 23:2286-98. 2008
    ..The present study sought to quantify this mass balance error (MBE) and explore potential explanatory factors...
  70. ncbi The DOse REsponse Multicentre International Collaborative Initiative (DO-RE-MI)
    G Monti
    Department of Anesthesiology and Intensive Care, Hospital Niguarda, Milan, Italy, and Anesthesiology Clinic, University of Dusseldorf, Germany
    Contrib Nephrol 156:434-43. 2007
    ..Here, we report the first preliminary descriptive analysis after 1-year recruitment...
  71. ncbi The ins and outs of renal trauma
    Vicky D Cassabaum
    General Hospital Trauma Services, Denver, CO, USA
    Am J Nurs . 2002
    ..Early identification of renal injury can be life saving...
  72. ncbi Fluid and volume monitoring
    M R Pinsky
    Critical Care Medicine, Bioengineering, Cardiovascular Diseases and Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Int J Artif Organs 31:111-26. 2008
    ..Thus, compensated shock with a normal blood pressure is a major cause of AKI or exacerbations of AKI during ultrafiltration...
  73. ncbi The outcome of acute renal failure in the intensive care unit according to RIFLE: model application, sensitivity, and predictability
    Nihal Y Abosaif
    Sheffield Kidney Institute and Intensive Care Unit, Northern General Hospital, University of Sheffield, UK
    Am J Kidney Dis 46:1038-48. 2005
    ....
  74. ncbi Management of acute renal failure
    Eddie Needham
    Emory University School of Medicine, Atlanta, Georgia 30338, USA
    Am Fam Physician 72:1739-46. 2005
    ..13 and the absolute risk reduction was 11.9 percent. Dopamine and diuretics have been shown to be ineffective in ameliorating the course of acute renal failure...
  75. ncbi [Recommendations for prevention of roentgen contrast medium-induced nephropathy]
    M Mockel
    Charité Campus Virchow Klinikum und Campus Berlin Buch Franz Volhard Klinik Medizinische Klinik mit Schwerpunkt Kardiologie Augustenburger Platz 1 13353 Berlin
    Z Kardiol 91:719-26. 2002
  76. ncbi [Treatment of patients with urinary tract obstruction and significant renal impairment]
    Henrikas Ramonas
    Clinic of Nephrourology, Vilnius University, Lithuania
    Medicina (Kaunas) 38:30-5. 2002
    ....
  77. ncbi Effect of hydroxyethylstarch on renal function in cardiac surgery: a large scale retrospective study
    P Wiesen
    General Intensive Care, , Domaine Universitaire du Sart Tilman, , Belgium
    Acta Anaesthesiol Belg 56:257-63. 2005
    ..CONCLUSION: The use of HES 200 kD, 0.5 DS in cardiac surgery does not seem to be associated with a clinically significant deterioration of postoperative renal function...
  78. ncbi Technology Insight: treatment of renal failure in the intensive care unit with extended dialysis
    Danilo Fliser
    Division of Nephrology, Department of Internal Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Nat Clin Pract Nephrol 2:32-9. 2006
    ....
  79. ncbi Acute renal failure in patients with rhabdomyolysis
    Wladyslaw Sułowicz
    Department of Nephrology, Jagiellonian University Hospital, Cracow, Poland
    Med Sci Monit 8:CR24-7. 2002
    ..Rhabdomyolysis is a relatively rare, not always diagnosed cause of acute renal failure (ARF). This fact motivated us to present the results of ARF treatment in the course of this polyetiological clinical syndrome...
  80. ncbi Mathematical estimation of recovery after loss of activity: I. Renal failure
    Merla J Hübler
    Department of Surgery, Washington University, Saint Louis, Missouri, USA
    J Trauma 63:232-8. 2007
  81. ncbi In severe acute kidney injury, a higher serum creatinine is paradoxically associated with better patient survival
    Jorge Cerda
    Deptartment of Medicine, St Peter s Hospital, Albany, New York 12209, USA
    Nephrol Dial Transplant 22:2781-4. 2007
    ..Our findings did not support a role of nutrition or muscle mass for this association. All these possibilities are worthy of thorough investigation, as findings will likely result in important changes in patient outcome...
  82. ncbi [Acute renal failure. Extracorporeal therapy]
    J T Kielstein
    Abteilung Nephrologie OE 6840, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover
    Internist (Berl) 48:786-94. 2007
    ..Therefore, the choice of renal replacement therapy should be based on personal experience, the available resources/infrastructure as well as the needs of the individual patient...
  83. ncbi Renal replacement strategies in the ICU
    Stefan John
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Chest 132:1379-88. 2007
    ....
  84. ncbi Pharmacokinetics and antimicrobial dosing adjustment in critically ill patients during continuous renal replacement therapy
    D Kuang
    Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Vicenza, Italy
    Clin Nephrol 67:267-84. 2007
    ..Meanwhile, monitoring the drug serum concentration is still mandatory whenever clinically feasible...
  85. ncbi [Bleeding complication due to accumulation of low-molecular-weight heparin in a patient with renal insufficiency]
    S Schneiter
    Abteilung für Nephrologie, Kantonsppital Aarau
    Praxis (Bern 1994) 96:733-7. 2007
    ..They are as safe and efficient compared to unfractioned heparin. But due to their renal elimination, they have to be monitored by measuring anti-factor Xa-activity if creatinine-clearance is <30 ml/min...
  86. ncbi Patient and kidney survival by dialysis modality in critically ill patients with acute kidney injury
    S Uchino
    Intensive Care Unit, Department of Anesthesiology, Jikei University School of Medicine, Tokyo Japan
    Int J Artif Organs 30:281-92. 2007
    ..We conclude that worldwide, the choice of CRRT as initial therapy is not a predictor of hospital survival or dialysis-free hospital survival but is an independent predictor of renal recovery among survivors...
  87. ncbi Continuous renal replacement in critical illness
    Claudio Ronco
    Department of Nephrology, San Bortolo Hospital, Vicenza, Italy
    Contrib Nephrol 156:309-19. 2007
    ..This article reviews recent trials comparing CRRT and IHD, and discusses their results and limitations...
  88. ncbi [Renal replacement therapy in the intensive care unit. Current aspects]
    T M Bingold
    Klinik fur Anasthesiologie, Intensivmedizin und Schmerztherapie, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt a M
    Anaesthesist 56:1105-14. 2007
    ....
  89. ncbi A comparison of continuous renal replacement therapy to intermittent dialysis in the management of renal insufficiency in the acutely III surgical patient
    Jimmy Waldrop
    Department of Surgery, UT College of Medicine, Chattanooga, Tennessee, USA
    Am Surg 71:36-9. 2005
    ..Prospective randomized controlled studies and larger sample sizes are needed to further evaluate these modalities...
  90. ncbi [Factors related to renal dysfunction after liver transplantation in patients with normal preoperative function]
    M Koo
    Unidad de Trasplante Hepático del Hospital Universitario de Bellvitge, Barcelona
    Rev Esp Anestesiol Reanim 53:538-44. 2006
    ..To determine perioperative factors related to postoperative renal dysfunction in patients receiving liver transplants who had normal renal function before surgery...
  91. ncbi Continuous venovenous haemofiltration using a citrate buffered substitution fluid
    M Schmitz
    Clinic for Nephrology, University Hospital, Dusseldorf, Germany
    Anaesth Intensive Care 35:529-35. 2007
    ..It is easy to apply and safe. Clearance can be varied as long as a constant ratio between blood and substitution flow is maintained...
  92. ncbi [Acute renal failure in critically ill patients]
    Palle Toft
    Odense Universitetshospital, Anaestesiologisk intensiv afdeling V, Odense C
    Ugeskr Laeger 169:692-5. 2007
    ..Non-dialytic therapy is early volume resuscitation whereas furosemid may worsen ARF. At the present time the dialytic therapy of choice in ICU patients with ARF is continuous renal replacement therapy (CRRT)...
  93. ncbi Efficacy of cellulose triacetate dialyzer and polysulfone synthetic hemofilter for continuous venovenous hemofiltration in acute renal failure
    Warangkana Pichaiwong
    Department of Medicine, Sirindhorn Hospital
    J Med Assoc Thai 89:S65-72. 2006
    ..CONCLUSION: Because of the excellent efficacy and the much cheaper cost, the modified cellulose membrane could be an appropriate alternative to standard synthetic membrane in CRRT...
  94. ncbi Do we know the optimal dose for renal replacement therapy in the intensive care unit?
    R Bellomo
    Department of Intensive Care, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
    Kidney Int 70:1202-4. 2006
    ..The results of these two studies should be available in 2008. Before making any major changes to practice, it seems prudent to wait for the publication of the findings of these two pivotal trials...
  95. ncbi Acute renal failure during pregnancy--an unusual cause
    Shobhana G Nayak
    Department of Nephrology, St John's Medical College Hospital, Sarjapur Road, Bangalore 560 034, India
    Nephrol Dial Transplant 22:264-5. 2007
  96. ncbi Acute renal failure in a patient with paroxysmal nocturnal hemoglobinuria
    M D Jose
    Department of Nephrology, Christchurch Hospital, New Zealand
    Clin Nephrol 56:172-4. 2001
    ..Renal biopsy demonstrated acute tubular necrosis with considerable hemosiderin deposition, but no evidence of vascular thrombosis...
  97. ncbi Use of EPO in critically ill patients with acute renal failure requiring renal replacement therapy
    Jeanie Park
    Division of General Medical Sciences, Department of Internal Medicine, Washington University, St Louis, MO 63110, USA
    Am J Kidney Dis 46:791-8. 2005
    ..A randomized controlled trial is needed to evaluate the potential benefits of EPO use in patients with ARF...
  98. ncbi Continuous renal replacement therapy
    Marcello Tonelli
    Can J Anaesth 52:1001-2; author reply 1002. 2005
  99. ncbi Estimating the impact of renal replacement therapy choice on outcome in severe acute renal failure
    R D Swartz
    Department of Internal Medicine, Division of Nephrology, University of Michigan Health System, Ann Arbor, MI 48109 0364, USA
    Clin Nephrol 63:335-45. 2005
    ..To date, no prospective controlled trial has sufficiently answered this question, and the present prospective outcome study attempts to compare survival with CRRT versus that with IHD...
  100. ncbi Blood purification in the intensive care unit
    Rafael Ponikvar
    Dialysis Center Zaloska, Department of Nephrology, University Medical Center Ljubljana, Slovenia
    Nephrol Dial Transplant 18:v63-7. 2003
    ..The mortality rate of patients with septic shock and fulminant hepatic failure was still very high, and the role of apheresis and dialysis, in spite of some encouraging results, remains controversial...
  101. ncbi Early and vigorous fluid resuscitation prevents acute renal failure in the crush victims of catastrophic earthquakes
    Ali Ihsan Gunal
    Department of Nephrology, Firat University Medical Faculty, Istanbul University, Istanbul, Turkey
    J Am Soc Nephrol 15:1862-7. 2004
    ..Early and vigorous fluid resuscitation followed by mannitol-alkaline diuresis prevents acute renal failure in crush victims, resulting in a more favorable outcome...

Research Grants94

  1. Acute Kidney Failure in a Cancer ICU
    Joshua Samuels; Fiscal Year: 2007
    ..independent clinical investigator, and to gain important knowledge regarding the development and outcome of acute kidney failure (AKF)...
  2. Identification of novel genes regulating metalloproteinase activity
    Andreas Herrlich; Fiscal Year: 2007
    ..As example, acute kidney failure and heart failure still have a very high mortality despite years of clinical and basic research...
  3. Improving Kidney Transplant Outcome with a Novel Complement Inhibitor
    SHELLEY MAVES; Fiscal Year: 2007
    ..Delayed Graft Function (DGF) is a form of acute kidney failure that occurs in up to 50% of transplants and relates directly to graft performance and patient outcome...
  4. Structure Based design of Meprin A Inhibitors for Acute Nephropathy
    Kal Ramnarayan; Fiscal Year: 2007
    ..in cultured cells and live rodents suggest that meprin A activity plays a key role in the etiology of acute kidney failure. This deadly disease affects over 250,000 Americans each year, with a 60% death rate...
  5. Epithelial/Dendritic Cell Cross-Talk in Acute Kidney Injury
    William Reeves; Fiscal Year: 2009
    ....
  6. Pathogenicity of Shiga Toxin-Producing E. coli
    ALISON O BRIEN; Fiscal Year: 2007
    ..the hemolytic uremic syndrome (HUS), a sequela of O 157:H7 infection, is the most frequent basis for acute kidney failure in U.S. children...
  7. Relative Roles of HSP70 and HSP25 in the Modulation of Renal Injury
    Rajasree Sreedharan; Fiscal Year: 2007
    ..The proposed studies will help understand the molecular processes involved in acute kidney failure and recovery...
  8. PATHOGENICITY OF SHIGA TOXIN PRODUCING E COLI (STEC)
    ALISON O BRIEN; Fiscal Year: 2002
    ..the hemolytic uremic syndrome (HUS), as a sequela of 0157:H7 infection, is the most frequent basis for acute kidney failure in U.S. children...
  9. CYTOPROTECTIVE ROLE OF HSP72 IN RENAL CELL INJURY
    Steven C Borkan; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Acute kidney failure is a common and often a life-threatening consequence of reduced blood flow (ischemia) to the organ...
  10. Pathophysiology of sepsis-induced renal injury
    Pierre C Dagher; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Acute kidney failure and sepsis represent a major healthcare burden in the US with a cost exceeding millions of dollars yearly. ..
  11. Protocolized Goal-directed Resuscitation of Septic Shock to Prevent AKI (ProGReSS
    John A Kellum; Fiscal Year: 2010
    ....
  12. Systems Engineering of Pheresis Intervention for Sepsis
    John Kellum; Fiscal Year: 2007
    ..We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.). ..
  13. Biological Markers of Recovery for the Kidney
    John A Kellum; Fiscal Year: 2010
    ..For analyses requiring serial samples and urine samples, we propose to study a subset of trial patients enrolled at 5 sites who consent to additional sample collection (208 patients) ..
  14. Systems Engineering of Pheresis Intervention for Sepsis
    John Kellum; Fiscal Year: 2009
    ..We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.). ..
  15. Biological Markers of Recovery for the Kidney
    John Kellum; Fiscal Year: 2007
    ..For analyses requiring serial samples and urine samples, we propose to study a subset of trial patients enrolled at 5 sites who consent to additional sample collection (208 patients) ..
  16. Endothelial Injury in Endotoxin-Induced Acute Renal Failure
    Patrick N Cunningham; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Acute kidney failure (ARF) is a common complication in hospitalized patients that leads to great morbidity and mortality, and ..
  17. MECHANISMS IN MYOGLOBINURIC ACUTE RENAL FAILURE
    RICHARD ZAGER; Fiscal Year: 1993
    ..By addressing the above, new insights into heme protein/low molecular weight protein nephrotoxicity and shock-induced renal damage will be obtained which should have direct relevance to crush syndrome induced ARF...
  18. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2007
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  19. Acute Renal Failure: Mechanisms and Adaptive Responses
    RICHARD ZAGER; Fiscal Year: 2007
    ....
  20. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  21. ACUTE RENAL FAILURE--MECHANISMS AND ADAPTIVE RESPONSES
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  22. Rho GTPases and Actin Cytoskeletal Function in Renal Ischemia
    Simon J Atkinson; Fiscal Year: 2010
    ..Narrative Ischemia (loss of blood flow) is a major cause of acute kidney failure. Currently there is a poor understanding of the way that kidney cells respond to ischemia, which makes it ..
  23. Rho GTPases and Actin Cytoskeletal Function in Renal Ischemia
    Simon Atkinson; Fiscal Year: 2009
    ..Narrative Ischemia (loss of blood flow) is a major cause of acute kidney failure. Currently there is a poor understanding of the way that kidney cells respond to ischemia, which makes it ..
  24. Rho GTPases and Actin Cytoskeletal Function in Renal Ischemia
    Simon J Atkinson; Fiscal Year: 2010
    ..Narrative Ischemia (loss of blood flow) is a major cause of acute kidney failure. Currently there is a poor understanding of the way that kidney cells respond to ischemia, which makes it ..
  25. Linking acute, chronic and end-stage renal disease
    Chi yuan Hsu; Fiscal Year: 2007
    ..Better understanding of the epidemiology and natural history of chronic renal insufficiency and the impact of acute renal failure will lead to improved patient management and better public health policies. ..
  26. Training Program in the Pathophysiology of Renal Disease
    Sudhir Shah; Fiscal Year: 2007
    ....
  27. Acute Renal Failure Mediated Lung Injury
    Sarah Faubel; Fiscal Year: 2009
    ....
  28. PREDICTING AND IMPROVING OUTCOMES IN ACUTE RENAL FAILURE
    Ravindra Mehta; Fiscal Year: 2001
    ..It is anticipated (by the applicants) that information gained from this study, being largely observational, will be used to rationally design intervention strategies in future years. ..
  29. CYTOPROTECTIVE ROLE OF HSP72 IN RENAL CELL INJURY
    STEVEN BORKAN; Fiscal Year: 2007
    ..These insights can prompt the development of preemptive strategies for preventing renal cell injury during ischemic insults as well as other forms of renal injury in which apoptosis contributes to organ failure. ..
  30. T cell modulation of renal ischemia reperfusion injury.
    Hamid Rabb; Fiscal Year: 2006
    ..The long term goal will be to identify the antigens and molecular pathways that fuel the injury processes in ARF and develop targeted therapies. ..
  31. MECHANISMS OF RENAL TUBULAR EPITHELIAL CELL INJURY
    Sudhir Shah; Fiscal Year: 2005
    ..abstract_text> ..
  32. Heart failure, chronic kidney disease, and renin-angiotensin system inhibition
    Ali Ahmed; Fiscal Year: 2009
    ....
  33. CLINICAL RESEARCH ENHANCEMENT FROM SUPPLEMENTAL TRAINING
    Ravindra Mehta; Fiscal Year: 2007
    ..IOur goal is to ensure that scholars emerging from this program will have the fundamental skills Inecessary for independent clinical research. ..