acute kidney failure

Summary

Summary: A severe stage of acute renal insufficiency, characterized by the sudden decrease in GLOMERULAR FILTRATION RATE to less than 15 ml per min, sometime to less than 1 to 2 ml per min. It is usually associated with OLIGURIA; EDEMA; and increase in BLOOD UREA NITROGEN and serum CREATININE concentrations.

Top Publications

  1. pmc Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
    Rinaldo Bellomo
    Department of Intensive Care and Medicine, Austin Health, Melbourne, Australia
    Crit Care 8:R204-12. 2004
  2. pmc Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury
    Ravindra L Mehta
    Department of Medicine, University of California San Diego Medical Center 8342, 200 W, Arbor Drive, San Diego, CA 92103, USA
    Crit Care 11:R31. 2007
  3. ncbi Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury
    Jaya Mishra
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Am Soc Nephrol 14:2534-43. 2003
  4. ncbi Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery
    Jaya Mishra
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Lancet 365:1231-8. 2005
  5. ncbi Administered mesenchymal stem cells enhance recovery from ischemia/reperfusion-induced acute renal failure in rats
    Claudia Lange
    Department of Bone Marrow Transplantation, University of Hamburg, Hamburg, Germany
    Kidney Int 68:1613-7. 2005
  6. ncbi Acute kidney injury associated with cardiac surgery
    Mitchell H Rosner
    Division of Nephrology, Department of Internal Medicine, University of Virginia Health System, Box 800133, Charlottesville, VA 22908, USA
    Clin J Am Soc Nephrol 1:19-32. 2006
  7. ncbi Ischemic acute renal failure: an inflammatory disease?
    Joseph V Bonventre
    Medical Services, Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, and Harvard Massachusetts Institute of Technology, Division of Health Sciences and Technology, Charlestown, USA
    Kidney Int 66:480-5. 2004
  8. ncbi Urinary IL-18 is an early predictive biomarker of acute kidney injury after cardiac surgery
    C R Parikh
    Section of Nephrology, Yale University, New Haven, Connecticut 06516, USA
    Kidney Int 70:199-203. 2006
  9. ncbi Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: role of macrophages
    Yuan Ji Day
    Div of Nephrology, Box 133, Univ of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Physiol Renal Physiol 288:F722-31. 2005
  10. ncbi Emerging biomarkers of acute kidney injury
    Prasad Devarajan
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Contrib Nephrol 156:203-12. 2007

Detail Information

Publications294 found, 100 shown here

  1. pmc Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
    Rinaldo Bellomo
    Department of Intensive Care and Medicine, Austin Health, Melbourne, Australia
    Crit Care 8:R204-12. 2004
    ..Accordingly, we sought to review the available evidence, make recommendations and delineate key questions for future studies...
  2. pmc Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury
    Ravindra L Mehta
    Department of Medicine, University of California San Diego Medical Center 8342, 200 W, Arbor Drive, San Diego, CA 92103, USA
    Crit Care 11:R31. 2007
    ..We describe an initiative to develop uniform standards for defining and classifying AKI and to establish a forum for multidisciplinary interaction to improve care for patients with or at risk for AKI...
  3. ncbi Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury
    Jaya Mishra
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Am Soc Nephrol 14:2534-43. 2003
    ..The results indicate that NGAL may represent an early, sensitive, noninvasive urinary biomarker for ischemic and nephrotoxic renal injury...
  4. ncbi Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery
    Jaya Mishra
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Lancet 365:1231-8. 2005
    ..We tested the hypothesis that neutrophil gelatinase-associated lipocalin (NGAL) is an early biomarker for ischaemic renal injury after cardiopulmonary bypass...
  5. ncbi Administered mesenchymal stem cells enhance recovery from ischemia/reperfusion-induced acute renal failure in rats
    Claudia Lange
    Department of Bone Marrow Transplantation, University of Hamburg, Hamburg, Germany
    Kidney Int 68:1613-7. 2005
    ..The aim of this study was, therefore, to evaluate the therapeutic effectiveness of bone marrow-derived mesenchymal stem cells in a rat model of ischemia/reperfusion (I/R) ARF...
  6. ncbi Acute kidney injury associated with cardiac surgery
    Mitchell H Rosner
    Division of Nephrology, Department of Internal Medicine, University of Virginia Health System, Box 800133, Charlottesville, VA 22908, USA
    Clin J Am Soc Nephrol 1:19-32. 2006
    ..Several compounds such as atrial natriuretic peptide and N-acetylcysteine have shown promise, but large-scale trials are needed...
  7. ncbi Ischemic acute renal failure: an inflammatory disease?
    Joseph V Bonventre
    Medical Services, Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, and Harvard Massachusetts Institute of Technology, Division of Health Sciences and Technology, Charlestown, USA
    Kidney Int 66:480-5. 2004
    ..Understanding the inflammatory response prevalent in ischemic kidney injury will facilitate identification of molecular targets for therapeutic intervention...
  8. ncbi Urinary IL-18 is an early predictive biomarker of acute kidney injury after cardiac surgery
    C R Parikh
    Section of Nephrology, Yale University, New Haven, Connecticut 06516, USA
    Kidney Int 70:199-203. 2006
    ..The combination of these two biomarkers may allow for the reliable early diagnosis and prognosis of AKI at all times after CPB, much before the rise in serum creatinine...
  9. ncbi Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: role of macrophages
    Yuan Ji Day
    Div of Nephrology, Box 133, Univ of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Physiol Renal Physiol 288:F722-31. 2005
    ..We conclude that the full extent of IRI requires macrophages and that A(2A) agonist-mediated tissue protection is independent of activation of macrophage A(2A)Rs...
  10. ncbi Emerging biomarkers of acute kidney injury
    Prasad Devarajan
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Contrib Nephrol 156:203-12. 2007
    ..Acute kidney injury (AKI) is a major clinical problem with a rising incidence and high mortality rate. The lack of early biomarkers has resulted in an unacceptable delay in initiating therapies...
  11. ncbi Acute renal failure in critically ill patients: a multinational, multicenter study
    Shigehiko Uchino
    Department of Intensive Care, Austin Hospital, Melbourne, Australia
    JAMA 294:813-8. 2005
    ....
  12. ncbi Declining mortality in patients with acute renal failure, 1988 to 2002
    Sushrut S Waikar
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    J Am Soc Nephrol 17:1143-50. 2006
    ..4% in 1988 to 26.6% in 2002 (P < 0.001). This study provides evidence from an administrative database that the incidence of ARF and ARF-D is rising. Despite an increase in the degree of comorbidity, in-hospital mortality has declined...
  13. doi Epidemiology of acute kidney injury: how big is the problem?
    Eric A J Hoste
    Intensive Care Unit, Ghent University Hospital, Ghent, Belgium
    Crit Care Med 36:S146-51. 2008
    ..Acute kidney injury (AKI) is a complication that occurs frequently in hospitalized patients. In this article, we provide an overview of the literature on the epidemiology of AKI in hospitalized patients...
  14. pmc Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock
    Derek S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Crit Care Med 36:1297-303. 2008
    ..To validate serum neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for acute kidney injury in critically ill children with septic shock...
  15. ncbi Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function
    D P Basile
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Renal Physiol 281:F887-99. 2001
    ..We hypothesize that severe ischemic injury results in a permanent alteration of renal capillary density, contributing to a urinary concentrating defect and the predisposition toward the development of renal fibrosis...
  16. ncbi Apoptotic pathways in ischemic acute renal failure
    Gur P Kaushal
    Department of Medicine, Division of Nephrology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Kidney Int 66:500-6. 2004
    ..It is likely that the cascades that lead to apoptotic or necrotic mode of cell death are activated almost simultaneously and may share some common pathways...
  17. pmc Intensity of renal support in critically ill patients with acute kidney injury
    Paul M Palevsky
    N Engl J Med 359:7-20. 2008
    ..The optimal intensity of renal-replacement therapy in critically ill patients with acute kidney injury is controversial...
  18. ncbi Gene expression in early ischemic renal injury: clues towards pathogenesis, biomarker discovery, and novel therapeutics
    Prasad Devarajan
    Department of Nephrology, Cincinnati Children s Hospital, Medical Center and Research Foundation, 3333 Burnet Avenue, MLC 7022, Cincinnati, OH 45229 3039, USA
    Mol Genet Metab 80:365-76. 2003
    ..The implications of these findings to the ability of the kidney to repair itself and potential strategies for accelerating recovery are briefly discussed...
  19. doi Urinary neutrophil gelatinase-associated lipocalin (NGAL) as an early marker of acute kidney injury in critically ill multiple trauma patients
    Konstantinos Makris
    Clinical Biochemistry Department, KAT General Hospital, Kiffissia, Athens, Greece
    Clin Chem Lab Med 47:79-82. 2009
    ..The aim of this study was to evaluate urinary NGAL levels as a predictor of early AKI (first 5 days after injury) in multi-trauma patients...
  20. ncbi Intra-abdominal hypertension and acute renal failure in critically ill patients
    Lidia Dalfino
    Department of Emergency and Organ Transplantation, Anesthesia and Intensive Care Unit, University of Bari, Piazza G Cesare 11, 70124, Bari, Italy
    Intensive Care Med 34:707-13. 2008
    ..To investigate the relationship between intra-abdominal hypertension (IAH) and acute renal failure (ARF) in critically ill patients...
  21. ncbi Biomarkers for the diagnosis and risk stratification of acute kidney injury: a systematic review
    S G Coca
    Clinical Epidemiology Research Center, Veterans Affairs Medical Center, West Haven, Connecticut 06516, USA
    Kidney Int 73:1008-16. 2008
    ..These biomarkers need validation in larger studies, and the generalizability of biomarkers to different types of AKI as well as the incremental prognostic value over traditional clinical variables needs to be determined...
  22. ncbi Kidney NGAL is a novel early marker of acute injury following transplantation
    Jaya Mishra
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Pediatr Nephrol 21:856-63. 2006
    ..We conclude that NGAL staining intensity in early protocol biopsies represents a novel predictive biomarker of acute kidney injury following transplantation...
  23. ncbi Inflammatory cells in ischemic acute renal failure
    John J Friedewald
    Renal Divisions, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA
    Kidney Int 66:486-91. 2004
    ..New tools to modulate inflammatory cells, particularly mononuclear leukocytes, hold promise for clinical trials in ARF...
  24. pmc Clinical review: RIFLE and AKIN--time for reappraisal
    Dinna N Cruz
    Department of Nephrology, Ospedale San Bortolo, Viale Rodolfi 37, 36100 Vicenza, Italy
    Crit Care 13:211. 2009
    ..As new data emerge, integration of novel biomarkers into the consensus definition will be a welcome refinement...
  25. ncbi Acute renal failure in patients with sepsis in a surgical ICU: predictive factors, incidence, comorbidity, and outcome
    Eric A J Hoste
    Intensive Care Unit and Renal Unit, Ghent University Hospital, Gent, Belgium
    J Am Soc Nephrol 14:1022-30. 2003
    ..This model allows initiating specific therapeutic measures earlier in the course of sepsis, hopefully resulting in a lower incidence of ARF and needi for RRT, thereby lowering mortality...
  26. ncbi Acute renal failure in endotoxemia is caused by TNF acting directly on TNF receptor-1 in kidney
    Patrick N Cunningham
    Section of Nephrology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    J Immunol 168:5817-23. 2002
    ..Therefore, TNF is a key mediator of LPS-induced ARF, acting through its receptor TNFR1 in the kidney...
  27. ncbi Renal dysfunction and serious infections after open-heart surgery
    Charuhas V Thakar
    Department of Nephrology and Hypertension, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Kidney Int 64:239-46. 2003
    ..We studied the influence of preoperative renal function or postoperative acute renal failure (ARF) on the frequency of infections after open-heart surgery...
  28. pmc Serum cystatin C concentration as a marker of acute renal dysfunction in critically ill patients
    Patricia Villa
    Intensive Care Unit, Hospital Universitario La Paz, Madrid, Spain
    Crit Care 9:R139-43. 2005
    ..The aim of the present study was to analyze the utility of serum cystatin C as a marker of renal function in these patients...
  29. pmc Carboxypeptidase G2 rescue in patients with methotrexate intoxication and renal failure
    S Buchen
    Department of Paediatric Haematology Oncology, Children s Medical Hospital, University of Bonn, Bonn, Germany
    Br J Cancer 92:480-7. 2005
    ..In conclusion, administration of CPDG2 is a well-tolerated, safe and a very effective way of MTX elimination in delayed excretion due to renal failure...
  30. ncbi Renal ischemia/reperfusion injury: functional tissue preservation by anti-activated {beta}1 integrin therapy
    Ana Molina
    Hospital Ramon y Cajal, Departamento de Patologia, Carretera de Colmenar, Km 9 1, 28034 Madrid, Spain
    J Am Soc Nephrol 16:374-82. 2005
    ..In conclusion, the data provide evidence that HUTS-21 has a protective effect in renal IRI, preventing tubular epithelial cell detachment by preserving activated beta1 integrins functions...
  31. ncbi Treatment of acute kidney injury: an update on the management of renal replacement therapy
    Helbert Rondon-Berrios
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15240, USA
    Curr Opin Nephrol Hypertens 16:64-70. 2007
    ....
  32. ncbi Endothelial injury and dysfunction: role in the extension phase of acute renal failure
    Bruce A Molitoris
    Division of Nephrology, Department of Medicine, and the Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 66:496-9. 2004
    ..New diagnostic and therapeutic approaches to ischemic ARF must incorporate these finding to devise early recognition strategies and therapeutic approaches...
  33. ncbi Contrast-induced nephropathy
    Peter A McCullough
    Department of Medicine, Division of Cardiology, William Beaumont Hospital, 4949 Coolidge, Royal Oak, MI 48073, USA
    Crit Care Clin 21:261-80. 2005
    ..5 mg/dL) can be predicted by using multivariate tools. Prevention measures include adequate hydration, use of N-acetylcysteine and iso-osmolar contrast, and for patients who are at the highest risk, prophylactic hemofiltration...
  34. ncbi Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat
    P K Chatterjee
    The William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, Charterhouse Square, London, England, United Kingdom
    Kidney Int 58:658-73. 2000
    ....
  35. ncbi Management of crush-related injuries after disasters
    Mehmet Sukru Sever
    Department of Internal Medicine, Istanbul School of Medicine, Istanbul, Turkey
    N Engl J Med 354:1052-63. 2006
  36. ncbi Early hemofiltration improves survival in post-cardiotomy patients with acute renal failure
    Maqsood M Elahi
    Department of Cardiothoracic Surgery, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Eur J Cardiothorac Surg 26:1027-31. 2004
    ..The aim of the present study was to identify how the timing of introduction of hemofiltration affects the morbidity and mortality in patients with ARF after cardiac surgery...
  37. doi Incidence and outcomes of acute kidney injury in intensive care units: a Veterans Administration study
    Charuhas V Thakar
    Nephrology, Cincinnati VA Medical Center, Cincinnati, OH, USA
    Crit Care Med 37:2552-8. 2009
    ..Acute kidney injury in intensive care unit patients is associated with significant mortality...
  38. ncbi Hemofiltration and peritoneal dialysis in infection-associated acute renal failure in Vietnam
    Nguyen Hoan Phu
    Center for Tropical Diseases, Center for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Vietnam
    N Engl J Med 347:895-902. 2002
    ..In resource-rich countries, it has been supplanted in recent years by hemodialysis and, most recently, by hemofiltration and associated techniques. The relative efficacy of peritoneal dialysis and hemofiltration is not known...
  39. pmc Acute kidney injury in intensive care unit patients: a comparison between the RIFLE and the Acute Kidney Injury Network classifications
    José António Lopes
    Department of Nephrology and Renal Transplantation, Hospital de Santa Maria, Av, Prof, Egas Moniz, Lisboa 1649 035, Portugal
    Crit Care 12:R110. 2008
    ..We evaluated the incidence of acute kidney injury and compared the ability of the maximum RIFLE and of the maximum AKIN within intensive care unit hospitalization in predicting inhospital mortality of critically ill patients...
  40. ncbi Pharmacologic treatment of acute kidney injury: why drugs haven't worked and what is on the horizon
    Sang Kyung Jo
    Department of Medicine, University of Virginia, Charlottesville, VA, USA
    Clin J Am Soc Nephrol 2:356-65. 2007
    ..Implementation of previous or novel compounds in well-designed clinical trials provides hope for the successful treatment of this devastating disorder...
  41. ncbi The prognostic importance of a small acute decrement in kidney function in hospitalized patients: a systematic review and meta-analysis
    Steven G Coca
    Clinical Epidemiology Research Center, VA Connecticut Healthcare System, West Haven, USA
    Am J Kidney Dis 50:712-20. 2007
    ..Recently, acute kidney injury defined by small changes in serum creatinine levels was associated with worse short-term outcomes; however, the precision and variability of this association was not fully explored...
  42. ncbi L-arginine deficiency and supplementation in experimental acute renal failure and in human kidney transplantation
    Lothar Schramm
    Department of Medicine, Division of Nephrology, Julius Maximilians University, Wurzburg, Germany
    Kidney Int 61:1423-32. 2002
    ..Thus, we investigated the effects of L-Arg supplementation immediately after kidney transplantation in 54 patients...
  43. doi Osmotic nephrosis: acute kidney injury with accumulation of proximal tubular lysosomes due to administration of exogenous solutes
    Michael Dickenmann
    Clinic for Transplantation Immunology and Nephrology, University Hospital, Basel, Switzerland
    Am J Kidney Dis 51:491-503. 2008
    ..It has a broad clinical spectrum that includes acute kidney injury and chronic kidney failure in rare cases. This article discusses the pathological characteristics, pathogenesis, and various clinical entities of osmotic nephrosis...
  44. doi Furosemide does not improve renal recovery after hemofiltration for acute renal failure in critically ill patients: a double blind randomized controlled trial
    Peter H J van der Voort
    Department of Intensive Care, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
    Crit Care Med 37:533-8. 2009
    ..To study the potential beneficial role of furosemide in resolving renal failure after hemofiltration in mechanically ventilated critically ill patients...
  45. ncbi Preventing renal failure in patients with rhabdomyolysis: do bicarbonate and mannitol make a difference?
    Carlos V R Brown
    Department of Surgery, Division of Trauma and Critical Care, University of Southern California and the Los Angeles County Medical Center, Los Angeles, California, USA
    J Trauma 56:1191-6. 2004
    ..The purpose of this study was to determine whether BIC/ MAN is effective in preventing RF in patients with rhabdomyolysis caused by trauma...
  46. doi Impact of minimal increases in serum creatinine on outcome in patients after cardiothoracic surgery: do we have to revise current definitions of acute renal failure?
    Andrea Lassnigg
    Department of Cardiothoracic and Vascular Anesthesia and Intensive Care Medicine, University Hospital of Vienna, A 1090 Vienna, Austria
    Crit Care Med 36:1129-37. 2008
    ....
  47. ncbi Insulin resistance in critically ill patients with acute renal failure
    Seema Basi
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
    Am J Physiol Renal Physiol 289:F259-64. 2005
    ..Insulin resistance as defined by hyperglycemia in the setting of higher insulin concentrations may be associated with mortality in critically ill patients with ARF. The IGF-IGFBP axis may play an important role in this process...
  48. ncbi Incidence, classification, and outcomes of acute kidney injury
    Eric A J Hoste
    Intensive Care Unit, Ghent University Hospital, Ghent, Belgium
    Contrib Nephrol 156:32-8. 2007
    ..Recent data emphasized the importance of less severe impairment of kidney function, hence the terminology acute kidney injury (AKI) was introduced...
  49. doi Acute kidney injury in patients with sepsis: a contemporary analysis
    José António Lopes
    Department of Nephrology and Renal Transplantation, Hospital de Santa Maria, Av Prof Egas Moniz, 1649 035, Lisbon, Portugal
    Int J Infect Dis 13:176-81. 2009
    ....
  50. ncbi Developing a consensus classification system for acute renal failure
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Curr Opin Crit Care 8:509-14. 2002
    ..Recommendations for validating a classification system are also considered...
  51. ncbi A multi-centre evaluation of the RIFLE criteria for early acute kidney injury in critically ill patients
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta Hospital, 3C1 16 Walter C Mackenzie Centre, 8440 122 Street, Edmonton, Alberta T6G2B7, Canada
    Nephrol Dial Transplant 23:1203-10. 2008
    ..We sought to evaluate the RIFLE criteria on the day of ICU admission in a large heterogenous population of critically ill patients...
  52. ncbi Nitric oxide in acute renal failure: NOS versus NOS
    Michael S Goligorsky
    Department of Medicine, State University of New York, Stony Brook, NY 11794 8152, USA
    Kidney Int 61:855-61. 2002
    ....
  53. ncbi Endotoxemic renal failure in mice: Role of tumor necrosis factor independent of inducible nitric oxide synthase
    M Knotek
    Department of Medicine, Division of Renal Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Kidney Int 59:2243-9. 2001
    ..The present study tested the hypothesis that the role of TNF in endotoxic renal failure is mediated by iNOS-derived NO...
  54. ncbi Spectrum of acute renal failure in the intensive care unit: the PICARD experience
    Ravindra L Mehta
    Division of Nephrology, Department of Medicine, University of California San Diego, San Diego, California, USA
    Kidney Int 66:1613-21. 2004
    ..Understanding the changing spectrum of ARF will be necessary to facilitate quality improvement efforts and to design successful interventional trials...
  55. ncbi Kidney dysfunction in the postoperative period
    J W Sear
    Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK
    Br J Anaesth 95:20-32. 2005
    ....
  56. pmc The local and systemic inflammatory transcriptome after acute kidney injury
    Dmitry N Grigoryev
    Division of Allergy and Clinical Immunology, 5501 Hopkins Bayview Circle, JHAAC 3A 62, Baltimore, Maryland, 21224, USA
    J Am Soc Nephrol 19:547-58. 2008
    ..Functional genomic analysis identified potential mediators that connect local and systemic inflammation, suggesting that this type of analysis may be a useful discovery tool for novel biomarkers and therapeutic drug development...
  57. ncbi Acute renal failure independently predicts mortality after myeloablative allogeneic hematopoietic cell transplant
    Chirag R Parikh
    Section of Nephrology, Yale University School of Medicine, New Haven, Connecticut 06473, USA
    Kidney Int 67:1999-2005. 2005
    ..Patients undergoing myeloablative allogeneic hematopoietic cell transplantation (HCT) have a high incidence of acute renal failure (ARF). However, it is unclear if ARF is independently associated with mortality after this procedure...
  58. ncbi The Prospective Pediatric Continuous Renal Replacement Therapy (ppCRRT) Registry: design, development and data assessed
    S L Goldstein
    Baylor College of Medicine, Houston, Texas, USA
    Int J Artif Organs 27:9-14. 2004
    ....
  59. ncbi Early renal replacement therapy in patients with postoperative acute liver failure associated with acute renal failure: effect on postoperative outcomes
    Vin Cent Wu
    Department of Internal Medicine, Yun Lin branch, National Taiwan University, Taipei, Taiwan
    J Am Coll Surg 205:266-76. 2007
    ..The optimal time to initiate renal replacement therapy for acute renal failure is controversial because of the poor overall clinical outcomes...
  60. ncbi Maladaptive role of IL-6 in ischemic acute renal failure
    Mariusz L Kielar
    Department of Internal Medicine Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Am Soc Nephrol 16:3315-25. 2005
    ..It is concluded that macrophages infiltrate the area of the vascular bundles of the outer medulla, these macrophages produce IL-6, and this IL-6 exacerbates ischemic murine acute renal failure...
  61. ncbi Acute renal failure and sepsis
    Robert W Schrier
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    N Engl J Med 351:159-69. 2004
  62. ncbi Epidemiology of acute renal failure: the tip of the iceberg
    Paul M Palevsky
    Clin J Am Soc Nephrol 1:6-7. 2006
  63. ncbi Mortality after acute renal failure: models for prognostic stratification and risk adjustment
    G M Chertow
    Department of Medicine Research, Division of Nephrology, University of California San Francisco, San Francisco, California, USA
    Kidney Int 70:1120-6. 2006
    ..By incorporating exposures over time, the discriminatory power of predictive models in ARF can be significantly improved...
  64. ncbi Dialysis modality and dosing strategy in acute renal failure
    Paul M Palevsky
    Renal Section, VA Pittsburgh Healthcare System, and University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15240, USA
    Semin Dial 19:165-70. 2006
    ..Similarly, although data suggest that continuous venovenous hemofiltration (CVVH) should be dosed at no less than 35 ml/kg/hr (postdilution), confirmation of this dosing strategy and validation for other modalities of CRRT are required...
  65. pmc TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity
    Ganesan Ramesh
    Division of Nephrology, Penn State College of Medicine, Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    J Clin Invest 110:835-42. 2002
    ..TNF-alpha appears to play a central role in the activation of this cytokine response and also in the pathogenesis of cisplatin renal injury...
  66. ncbi Acute renal failure after bilateral nephrectomy is associated with cytokine-mediated pulmonary injury
    Thomas S Hoke
    Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, CO80262, USA
    J Am Soc Nephrol 18:155-64. 2007
    ....
  67. pmc Bench-to-bedside review: Rhabdomyolysis -- an overview for clinicians
    Ana L Huerta-Alardín
    Universidad Autonoma de Tamaulipas School of Medicine, Tampico, Mexico
    Crit Care 9:158-69. 2005
    ..The most sensitive laboratory finding of muscle injury is an elevated plasma creatine kinase level. The management of patients with rhabdomyolysis includes early vigorous hydration...
  68. ncbi Diuretics, mortality, and nonrecovery of renal function in acute renal failure
    Ravindra L Mehta
    Division of Nephrology, University of California, San Diego, Medical Center, USA
    JAMA 288:2547-53. 2002
    ..Acute renal failure is associated with high mortality and morbidity. Diuretic agents continue to be used in this setting despite a lack of evidence supporting their benefit...
  69. ncbi Incidence and outcomes in acute kidney injury: a comprehensive population-based study
    Tariq Ali
    Departments of Medicine and Therapeutics, University of Aberdeen, Aberdeen, United Kingdom
    J Am Soc Nephrol 18:1292-8. 2007
    ..The RIFLE classification is useful for identifying patients at greatest risk of adverse short-term outcomes...
  70. ncbi Pathophysiology, clinical consequences, and treatment of tumor lysis syndrome
    Michael B Davidson
    Department of General Internal Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Med 116:546-54. 2004
    ..Recombinant urate oxidase (rasburicase), which recently became available in the United States, provides a safe and effective alternative to allopurinol for lowering uric acid levels and preventing uric acid nephropathy...
  71. ncbi Acute kidney failure in neonatal period
    Fakhrossadat Mortazavi
    Department of Pediatric Nephrology, Tabriz University of Medical Sciences, Tabriz, Iran
    Iran J Kidney Dis 3:136-40. 2009
    b>Acute kidney failure (AKF) is a common clinical problem in neonatal intensive care units and is usually associated with a contributing condition such as sepsis, asphyxia, and heart failure...
  72. pmc Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study
    Michael Bennett
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, OH 45229 3039, USA
    Clin J Am Soc Nephrol 3:665-73. 2008
    ..In this study, whether an NGAL immunoassay developed for a standardized clinical platform (ARCHITECT analyzer, Abbott Diagnostics Division, Abbott Laboratories, Abbott Park, IL) can predict AKI after CPB was tested...
  73. pmc Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort study
    Catherine L Dent
    Department of Cardiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, 3333 Burnet Ave, Cincinnati, Ohio 45229, USA
    Crit Care 11:R127. 2007
    ..In this study we tested whether a point-of-care NGAL device can predict AKI after CPB in a larger cohort...
  74. ncbi Plasma exchange when myeloma presents as acute renal failure: a randomized, controlled trial
    William F Clark
    University of Western Ontario, London, Ontario, Canada
    Ann Intern Med 143:777-84. 2005
    ..Two small, randomized trials provide conflicting evidence about the benefits of plasma exchange for patients with acute renal failure at the onset of multiple myeloma...
  75. ncbi The changing epidemiology of acute renal failure
    Norbert Lameire
    Ghent University, Ghent, Belgium
    Nat Clin Pract Nephrol 2:364-77. 2006
    ....
  76. ncbi Continuous renal replacement therapy: a worldwide practice survey. The beginning and ending supportive therapy for the kidney (B.E.S.T. kidney) investigators
    Shigehiko Uchino
    Jikei University School of Medicine, Intensive Care Unit, Department of Anesthesiology, Tokyo, Japan
    Intensive Care Med 33:1563-70. 2007
    ..Little information is available regarding current practice in continuous renal replacement therapy (CRRT) for the treatment of acute renal failure (ARF) and the possible clinical effect of practice variation...
  77. ncbi Identification of persistently altered gene expression in the kidney after functional recovery from ischemic acute renal failure
    David P Basile
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Physiol Renal Physiol 288:F953-63. 2005
    ..In summary, genes with known inflammatory, remodeling, and vasoactive activities were identified in rat kidneys after recovery from ARF, some of which may play a role in altering long-term renal function after recovery from ARF...
  78. ncbi Practice patterns in the management of acute renal failure in the critically ill patient: an international survey
    Zaccaria Ricci
    Department of Intensive Care, Policlinico Umberto I, Universita La Sapienza, Rome, Italy
    Nephrol Dial Transplant 21:690-6. 2006
    ..In this lack of harmony, the epidemiology of ARF has recently displayed an outbreak of cases in the intensive care units and nephrologists and intensivists are now called to work together in the case of such a syndrome...
  79. ncbi The endothelial cell in ischemic acute kidney injury: implications for acute and chronic function
    D P Basile
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 72:151-6. 2007
    ....
  80. ncbi Renal failure in the ICU: comparison of the impact of acute renal failure and end-stage renal disease on ICU outcomes
    Gilles Clermont
    Department of Critical Care Medicine and Renal Electrolyte Division, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Kidney Int 62:986-96. 2002
    ..We sought to determine the impact of renal dysfunction and/or loss of organ function on outcome...
  81. pmc Urinary biomarkers in the early diagnosis of acute kidney injury
    W K Han
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 73:863-9. 2008
    ..Urinary MMP-9 was not a sensitive marker in the case-control study. Our results suggest that urinary biomarkers allow diagnosis of acute kidney injury earlier than a rise in serum creatinine...
  82. ncbi Acute renal failure due to crush syndrome during Marmara earthquake
    Gulcin Kantarci
    Department of Nephrology, Marmara School of Medicine, Istanbul, Turkey
    Am J Kidney Dis 40:682-9. 2002
    ..In a similar disaster in the future, these factors should be taken into consideration for priority in referral to medical centers with dialysis facilities...
  83. ncbi Defining acute renal failure: the RIFLE criteria
    Ramesh Venkataraman
    The CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Intensive Care Med 22:187-93. 2007
    ..Also discussed are many of the challenges and controversies associated with achieving consensus and developing a classification for acute renal dysfunction...
  84. ncbi Nephrology consultation in acute renal failure: does timing matter?
    Ravindra L Mehta
    Division of Nephrology, Department of Medicine, University of California, San Diego, California, USA
    Am J Med 113:456-61. 2002
    ..The goals of this study were to identify correlates of the timing of nephrology consultation in acute renal failure, and to explore the relation between timing of consultation and outcomes...
  85. ncbi Clearance of ceftazidime during continuous venovenous haemofiltration in critically ill patients
    Friederike Traunmüller
    Department of Internal Medicine I, Division of Infectious Diseases, University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    J Antimicrob Chemother 49:129-34. 2002
    ..3 +/- 0.6 h, 32.1 +/- 7.9 mL/min, 36.4 +/- 6.4 L and 74.5 +/- 6.5%, respectively. Based on these pharmacokinetic parameters and that maximal killing is at 4 x MIC we recommend at least ceftazidime 2 g i.v. q8h...
  86. ncbi Timing of replacement therapy for acute renal failure after cardiac surgery
    Ufuk Demirkilic
    Cardiovascular Surgery Department, Etlik, Ankara, Turkey
    J Card Surg 19:17-20. 2004
    ..The aim of this study is to compare early and intensive use of continuous veno-venous hemodiafiltration (CVVHDF) with conservative usage of CVVHDF in patients with ARF after cardiac surgery...
  87. ncbi Dialytic treatment of rhabdomyolysis-induced acute renal failure: our experience
    G Splendiani
    Surgery Department, Tor Vergata University, Rome, Italy
    Ren Fail 23:183-91. 2001
    ..Nevertheless, the final outcome may be very different between ICU- and NICU-patients, with a higher mortality rate in ICU-patients, suffering from MODS...
  88. doi Rifle classification for predicting in-hospital mortality in critically ill sepsis patients
    Yung Chang Chen
    Departments of Nephrology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    Shock 31:139-45. 2009
    ..In conclusion, these findings are consistent with a role for RIFLE classification in accurately predicting in-hospital mortality and short-term prognosis in ICU sepsis patients...
  89. ncbi Acute renal failure
    Norbert Lameire
    Renal Division, Department of Medicine, University Hospital Ghent, De Pintelaan 185, 9000 Ghent, Belgium
    Lancet 365:417-30. 2005
    ..Finally, some information on the influence of gene polymorphisms on the prognosis of acute renal failure is given...
  90. ncbi Global analysis of gene expression in renal ischemia-reperfusion in the mouse
    Takumi Yoshida
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Cambridge, Massachusetts 02139, USA
    Biochem Biophys Res Commun 291:787-94. 2002
    ..Our data identified several novel genes that may be important in renal repair after ischemia...
  91. doi Pathophysiology of septic acute kidney injury: what do we really know?
    Li Wan
    Department of Intensive Care, Austin Hospital, Melbourne, Australia
    Crit Care Med 36:S198-203. 2008
    ..If this were to happen, our therapeutic approaches would also be profoundly altered...
  92. doi A comparison of the RIFLE and AKIN criteria for acute kidney injury in critically ill patients
    Sean M Bagshaw
    Department of Intensive Care, Austin Hospital, Heidelberg, Victoria 3084, Australia
    Nephrol Dial Transplant 23:1569-74. 2008
    ..The Acute Kidney Injury Network (AKIN) group has recently proposed modifications to this system. It is currently unknown whether there are advantages between these criteria...
  93. ncbi Influence of dialysis membranes on outcomes in acute renal failure: a meta-analysis
    Sanjay Subramanian
    Department of Medicine, Musselshell Medical Center, Roundup, Montana, USA
    Kidney Int 62:1819-23. 2002
    ..Thus, we sought to determine whether combining results from all published trials would provide a better estimate of the effect of membrane composition on survival in ARF...
  94. pmc Prognosis for long-term survival and renal recovery in critically ill patients with severe acute renal failure: a population-based study
    Sean M Bagshaw
    Department of Critical Care Medicine, Calgary Health Region, University of Calgary, Calgary, Alberta, Canada
    Crit Care 9:R700-9. 2005
    ..Severe acute renal failure (sARF) is associated with considerable morbidity, mortality and use of healthcare resources; however, its precise epidemiology and long-term outcomes have not been well described in a non-specified population...
  95. ncbi Phosphatemic control during acute renal failure: intermittent hemodialysis versus continuous hemodiafiltration
    H K Tan
    Department of Intensive Care, Austin and Repatriation Medical Centre, Melbourne, Victoria, Australia
    Int J Artif Organs 24:186-91. 2001
    ..3% vs. 5.6%; P<0.1) during CVVHDF CONCLUSIONS: Abnormal serum phosphate concentrations are frequent in ARF patients before and during renal replacement, however, normalization of phosphatemia is achieved more frequently with CVVHDF...
  96. doi Costs and outcomes of acute kidney injury (AKI) following cardiac surgery
    Joseph F Dasta
    College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    Nephrol Dial Transplant 23:1970-4. 2008
    ..We determined costs, resource use and mortality rate of patients. We used the serum creatinine component of the RIFLE system to classify AKI...
  97. ncbi Derivation and validation of a simplified predictive index for renal replacement therapy after cardiac surgery
    Duminda N Wijeysundera
    Department of Anesthesia, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada
    JAMA 297:1801-9. 2007
    ..A predictive index for renal replacement therapy (RRT; hemodialysis or continuous venovenous hemodiafiltration) after cardiac surgery may improve clinical decision making and research design...
  98. ncbi Survival and quality of life of patients requiring acute renal replacement therapy
    Annika Ahlström
    Intensive Care Unit, Division of Anesthesiology and Intensive Care Medicine, Department of Surgery, Helsinki University Central Hospital, Finland
    Intensive Care Med 31:1222-8. 2005
    ..To assess long-term survival and health-related quality of life in patients with acute renal failure...
  99. pmc RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis
    Eric A J Hoste
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    Crit Care 10:R73. 2006
    ..RIFLE, a newly developed international consensus classification for acute kidney injury, defines three grades of severity--risk (class R), injury (class I) and failure (class F)--but has not yet been evaluated in a clinical series...
  100. doi Dialysis in acute kidney injury--more is not better
    Joseph V Bonventre
    N Engl J Med 359:82-4. 2008
  101. doi Intensive insulin therapy and pentastarch resuscitation in severe sepsis
    Frank M Brunkhorst
    Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University, Jena, Germany
    N Engl J Med 358:125-39. 2008
    ..The role of intensive insulin therapy in patients with severe sepsis is uncertain. Fluid resuscitation improves survival among patients with septic shock, but evidence is lacking to support the choice of either crystalloids or colloids...

Research Grants94

  1. Acute Kidney Failure in a Cancer ICU
    Joshua Samuels; Fiscal Year: 2007
    ..independent clinical investigator, and to gain important knowledge regarding the development and outcome of acute kidney failure (AKF)...
  2. Identification of novel genes regulating metalloproteinase activity
    Andreas Herrlich; Fiscal Year: 2007
    ..As example, acute kidney failure and heart failure still have a very high mortality despite years of clinical and basic research...
  3. Improving Kidney Transplant Outcome with a Novel Complement Inhibitor
    SHELLEY MAVES; Fiscal Year: 2007
    ..Delayed Graft Function (DGF) is a form of acute kidney failure that occurs in up to 50% of transplants and relates directly to graft performance and patient outcome...
  4. Structure Based design of Meprin A Inhibitors for Acute Nephropathy
    Kal Ramnarayan; Fiscal Year: 2007
    ..in cultured cells and live rodents suggest that meprin A activity plays a key role in the etiology of acute kidney failure. This deadly disease affects over 250,000 Americans each year, with a 60% death rate...
  5. Epithelial/Dendritic Cell Cross-Talk in Acute Kidney Injury
    William Reeves; Fiscal Year: 2009
    ....
  6. Pathogenicity of Shiga Toxin-Producing E. coli
    ALISON O BRIEN; Fiscal Year: 2007
    ..the hemolytic uremic syndrome (HUS), a sequela of O 157:H7 infection, is the most frequent basis for acute kidney failure in U.S. children...
  7. Relative Roles of HSP70 and HSP25 in the Modulation of Renal Injury
    Rajasree Sreedharan; Fiscal Year: 2007
    ..The proposed studies will help understand the molecular processes involved in acute kidney failure and recovery...
  8. PATHOGENICITY OF SHIGA TOXIN PRODUCING E COLI (STEC)
    ALISON O BRIEN; Fiscal Year: 2002
    ..the hemolytic uremic syndrome (HUS), as a sequela of 0157:H7 infection, is the most frequent basis for acute kidney failure in U.S. children...
  9. CYTOPROTECTIVE ROLE OF HSP72 IN RENAL CELL INJURY
    Steven C Borkan; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Acute kidney failure is a common and often a life-threatening consequence of reduced blood flow (ischemia) to the organ...
  10. Pathophysiology of sepsis-induced renal injury
    Pierre C Dagher; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Acute kidney failure and sepsis represent a major healthcare burden in the US with a cost exceeding millions of dollars yearly. ..
  11. Protocolized Goal-directed Resuscitation of Septic Shock to Prevent AKI (ProGReSS
    John A Kellum; Fiscal Year: 2010
    ....
  12. Systems Engineering of Pheresis Intervention for Sepsis
    John Kellum; Fiscal Year: 2007
    ..We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.). ..
  13. Biological Markers of Recovery for the Kidney
    John A Kellum; Fiscal Year: 2010
    ..For analyses requiring serial samples and urine samples, we propose to study a subset of trial patients enrolled at 5 sites who consent to additional sample collection (208 patients) ..
  14. Systems Engineering of Pheresis Intervention for Sepsis
    John Kellum; Fiscal Year: 2009
    ..We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.). ..
  15. Biological Markers of Recovery for the Kidney
    John Kellum; Fiscal Year: 2007
    ..For analyses requiring serial samples and urine samples, we propose to study a subset of trial patients enrolled at 5 sites who consent to additional sample collection (208 patients) ..
  16. Endothelial Injury in Endotoxin-Induced Acute Renal Failure
    Patrick N Cunningham; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Acute kidney failure (ARF) is a common complication in hospitalized patients that leads to great morbidity and mortality, and ..
  17. MECHANISMS IN MYOGLOBINURIC ACUTE RENAL FAILURE
    RICHARD ZAGER; Fiscal Year: 1993
    ..By addressing the above, new insights into heme protein/low molecular weight protein nephrotoxicity and shock-induced renal damage will be obtained which should have direct relevance to crush syndrome induced ARF...
  18. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2007
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  19. Acute Renal Failure: Mechanisms and Adaptive Responses
    RICHARD ZAGER; Fiscal Year: 2007
    ....
  20. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  21. ACUTE RENAL FAILURE--MECHANISMS AND ADAPTIVE RESPONSES
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  22. Rho GTPases and Actin Cytoskeletal Function in Renal Ischemia
    Simon J Atkinson; Fiscal Year: 2010
    ..Narrative Ischemia (loss of blood flow) is a major cause of acute kidney failure. Currently there is a poor understanding of the way that kidney cells respond to ischemia, which makes it ..
  23. Rho GTPases and Actin Cytoskeletal Function in Renal Ischemia
    Simon Atkinson; Fiscal Year: 2009
    ..Narrative Ischemia (loss of blood flow) is a major cause of acute kidney failure. Currently there is a poor understanding of the way that kidney cells respond to ischemia, which makes it ..
  24. Rho GTPases and Actin Cytoskeletal Function in Renal Ischemia
    Simon J Atkinson; Fiscal Year: 2010
    ..Narrative Ischemia (loss of blood flow) is a major cause of acute kidney failure. Currently there is a poor understanding of the way that kidney cells respond to ischemia, which makes it ..
  25. Linking acute, chronic and end-stage renal disease
    Chi yuan Hsu; Fiscal Year: 2007
    ..Better understanding of the epidemiology and natural history of chronic renal insufficiency and the impact of acute renal failure will lead to improved patient management and better public health policies. ..
  26. Training Program in the Pathophysiology of Renal Disease
    Sudhir Shah; Fiscal Year: 2007
    ....
  27. Acute Renal Failure Mediated Lung Injury
    Sarah Faubel; Fiscal Year: 2009
    ....
  28. PREDICTING AND IMPROVING OUTCOMES IN ACUTE RENAL FAILURE
    Ravindra Mehta; Fiscal Year: 2001
    ..It is anticipated (by the applicants) that information gained from this study, being largely observational, will be used to rationally design intervention strategies in future years. ..
  29. CYTOPROTECTIVE ROLE OF HSP72 IN RENAL CELL INJURY
    STEVEN BORKAN; Fiscal Year: 2007
    ..These insights can prompt the development of preemptive strategies for preventing renal cell injury during ischemic insults as well as other forms of renal injury in which apoptosis contributes to organ failure. ..
  30. T cell modulation of renal ischemia reperfusion injury.
    Hamid Rabb; Fiscal Year: 2006
    ..The long term goal will be to identify the antigens and molecular pathways that fuel the injury processes in ARF and develop targeted therapies. ..
  31. MECHANISMS OF RENAL TUBULAR EPITHELIAL CELL INJURY
    Sudhir Shah; Fiscal Year: 2005
    ..abstract_text> ..
  32. Heart failure, chronic kidney disease, and renin-angiotensin system inhibition
    Ali Ahmed; Fiscal Year: 2009
    ....
  33. CLINICAL RESEARCH ENHANCEMENT FROM SUPPLEMENTAL TRAINING
    Ravindra Mehta; Fiscal Year: 2007
    ..IOur goal is to ensure that scholars emerging from this program will have the fundamental skills Inecessary for independent clinical research. ..