acute kidney failure

Summary

Summary: A severe stage of acute renal insufficiency, characterized by the sudden decrease in GLOMERULAR FILTRATION RATE to less than 15 ml per min, sometime to less than 1 to 2 ml per min. It is usually associated with OLIGURIA; EDEMA; and increase in BLOOD UREA NITROGEN and serum CREATININE concentrations.

Top Publications

  1. pmc Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
    Rinaldo Bellomo
    Department of Intensive Care and Medicine, Austin Health, Melbourne, Australia
    Crit Care 8:R204-12. 2004
  2. pmc Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury
    Ravindra L Mehta
    Department of Medicine, University of California San Diego Medical Center 8342, 200 W, Arbor Drive, San Diego, CA 92103, USA
    Crit Care 11:R31. 2007
  3. ncbi Acute renal failure in critically ill patients: a multinational, multicenter study
    Shigehiko Uchino
    Department of Intensive Care, Austin Hospital, Melbourne, Australia
    JAMA 294:813-8. 2005
  4. ncbi Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery
    Jaya Mishra
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Lancet 365:1231-8. 2005
  5. ncbi Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury
    Jaya Mishra
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Am Soc Nephrol 14:2534-43. 2003
  6. ncbi Administered mesenchymal stem cells enhance recovery from ischemia/reperfusion-induced acute renal failure in rats
    Claudia Lange
    Department of Bone Marrow Transplantation, University of Hamburg, Hamburg, Germany
    Kidney Int 68:1613-7. 2005
  7. ncbi Incidence and mortality of acute renal failure in Medicare beneficiaries, 1992 to 2001
    Jay L Xue
    United States Renal Data System, 914 South 8th Street, Suite D 206, Minneapolis, MN 55404, USA
    J Am Soc Nephrol 17:1135-42. 2006
  8. ncbi Declining mortality in patients with acute renal failure, 1988 to 2002
    Sushrut S Waikar
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    J Am Soc Nephrol 17:1143-50. 2006
  9. ncbi Acute kidney injury associated with cardiac surgery
    Mitchell H Rosner
    Division of Nephrology, Department of Internal Medicine, University of Virginia Health System, Box 800133, Charlottesville, VA 22908, USA
    Clin J Am Soc Nephrol 1:19-32. 2006
  10. pmc Prognosis for long-term survival and renal recovery in critically ill patients with severe acute renal failure: a population-based study
    Sean M Bagshaw
    Department of Critical Care Medicine, Calgary Health Region, University of Calgary, Calgary, Alberta, Canada
    Crit Care 9:R700-9. 2005

Detail Information

Publications327 found, 100 shown here

  1. pmc Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
    Rinaldo Bellomo
    Department of Intensive Care and Medicine, Austin Health, Melbourne, Australia
    Crit Care 8:R204-12. 2004
    ..Accordingly, we sought to review the available evidence, make recommendations and delineate key questions for future studies...
  2. pmc Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury
    Ravindra L Mehta
    Department of Medicine, University of California San Diego Medical Center 8342, 200 W, Arbor Drive, San Diego, CA 92103, USA
    Crit Care 11:R31. 2007
    ..We describe an initiative to develop uniform standards for defining and classifying AKI and to establish a forum for multidisciplinary interaction to improve care for patients with or at risk for AKI...
  3. ncbi Acute renal failure in critically ill patients: a multinational, multicenter study
    Shigehiko Uchino
    Department of Intensive Care, Austin Hospital, Melbourne, Australia
    JAMA 294:813-8. 2005
    ....
  4. ncbi Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery
    Jaya Mishra
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Lancet 365:1231-8. 2005
    ..We tested the hypothesis that neutrophil gelatinase-associated lipocalin (NGAL) is an early biomarker for ischaemic renal injury after cardiopulmonary bypass...
  5. ncbi Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury
    Jaya Mishra
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Am Soc Nephrol 14:2534-43. 2003
    ..The results indicate that NGAL may represent an early, sensitive, noninvasive urinary biomarker for ischemic and nephrotoxic renal injury...
  6. ncbi Administered mesenchymal stem cells enhance recovery from ischemia/reperfusion-induced acute renal failure in rats
    Claudia Lange
    Department of Bone Marrow Transplantation, University of Hamburg, Hamburg, Germany
    Kidney Int 68:1613-7. 2005
    ..The aim of this study was, therefore, to evaluate the therapeutic effectiveness of bone marrow-derived mesenchymal stem cells in a rat model of ischemia/reperfusion (I/R) ARF...
  7. ncbi Incidence and mortality of acute renal failure in Medicare beneficiaries, 1992 to 2001
    Jay L Xue
    United States Renal Data System, 914 South 8th Street, Suite D 206, Minneapolis, MN 55404, USA
    J Am Soc Nephrol 17:1135-42. 2006
    ..Those of older age, male gender, and black race are more likely to have ARF. These data show ARF to be a major contributor to morbidity and mortality in hospitalized patients...
  8. ncbi Declining mortality in patients with acute renal failure, 1988 to 2002
    Sushrut S Waikar
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    J Am Soc Nephrol 17:1143-50. 2006
    ..4% in 1988 to 26.6% in 2002 (P < 0.001). This study provides evidence from an administrative database that the incidence of ARF and ARF-D is rising. Despite an increase in the degree of comorbidity, in-hospital mortality has declined...
  9. ncbi Acute kidney injury associated with cardiac surgery
    Mitchell H Rosner
    Division of Nephrology, Department of Internal Medicine, University of Virginia Health System, Box 800133, Charlottesville, VA 22908, USA
    Clin J Am Soc Nephrol 1:19-32. 2006
    ..Several compounds such as atrial natriuretic peptide and N-acetylcysteine have shown promise, but large-scale trials are needed...
  10. pmc Prognosis for long-term survival and renal recovery in critically ill patients with severe acute renal failure: a population-based study
    Sean M Bagshaw
    Department of Critical Care Medicine, Calgary Health Region, University of Calgary, Calgary, Alberta, Canada
    Crit Care 9:R700-9. 2005
    ..Severe acute renal failure (sARF) is associated with considerable morbidity, mortality and use of healthcare resources; however, its precise epidemiology and long-term outcomes have not been well described in a non-specified population...
  11. ncbi Ischemic acute renal failure: an inflammatory disease?
    Joseph V Bonventre
    Medical Services, Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, and Harvard Massachusetts Institute of Technology, Division of Health Sciences and Technology, Charlestown, USA
    Kidney Int 66:480-5. 2004
    ..Understanding the inflammatory response prevalent in ischemic kidney injury will facilitate identification of molecular targets for therapeutic intervention...
  12. ncbi Urinary IL-18 is an early predictive biomarker of acute kidney injury after cardiac surgery
    C R Parikh
    Section of Nephrology, Yale University, New Haven, Connecticut 06516, USA
    Kidney Int 70:199-203. 2006
    ..The combination of these two biomarkers may allow for the reliable early diagnosis and prognosis of AKI at all times after CPB, much before the rise in serum creatinine...
  13. ncbi Effect of acute renal failure requiring renal replacement therapy on outcome in critically ill patients
    Philipp G H Metnitz
    Department of Reanimation Medicale, Hopital St Louis, University Lariboisière St Louis, Paris, France
    Crit Care Med 30:2051-8. 2002
    ..The aim of this study was to analyze severity of illness and mortality in a group of critically ill patients with acute renal failure requiring renal replacement therapy in a number of Austrian intensive care units...
  14. ncbi Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: role of macrophages
    Yuan Ji Day
    Div of Nephrology, Box 133, Univ of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Physiol Renal Physiol 288:F722-31. 2005
    ..We conclude that the full extent of IRI requires macrophages and that A(2A) agonist-mediated tissue protection is independent of activation of macrophage A(2A)Rs...
  15. ncbi Emerging biomarkers of acute kidney injury
    Prasad Devarajan
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Contrib Nephrol 156:203-12. 2007
    ..Acute kidney injury (AKI) is a major clinical problem with a rising incidence and high mortality rate. The lack of early biomarkers has resulted in an unacceptable delay in initiating therapies...
  16. doi Citrate anticoagulation for continuous venovenous hemofiltration
    Heleen M Oudemans-van Straaten
    Department of Intensive Care Medicine, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
    Crit Care Med 37:545-52. 2009
    ..Heparins used to prevent circuit clotting may cause bleeding. Regional anticoagulation with citrate reduces bleeding, but has metabolic risks. The aim was to compare the safety and efficacy of the two...
  17. ncbi Incidence and outcomes in acute kidney injury: a comprehensive population-based study
    Tariq Ali
    Departments of Medicine and Therapeutics, University of Aberdeen, Aberdeen, United Kingdom
    J Am Soc Nephrol 18:1292-8. 2007
    ..The RIFLE classification is useful for identifying patients at greatest risk of adverse short-term outcomes...
  18. ncbi Inflammatory cells in ischemic acute renal failure
    John J Friedewald
    Renal Divisions, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA
    Kidney Int 66:486-91. 2004
    ..New tools to modulate inflammatory cells, particularly mononuclear leukocytes, hold promise for clinical trials in ARF...
  19. ncbi A multi-centre evaluation of the RIFLE criteria for early acute kidney injury in critically ill patients
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta Hospital, 3C1 16 Walter C Mackenzie Centre, 8440 122 Street, Edmonton, Alberta T6G2B7, Canada
    Nephrol Dial Transplant 23:1203-10. 2008
    ..We sought to evaluate the RIFLE criteria on the day of ICU admission in a large heterogenous population of critically ill patients...
  20. ncbi Developing a consensus classification system for acute renal failure
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Curr Opin Crit Care 8:509-14. 2002
    ..Recommendations for validating a classification system are also considered...
  21. doi Development and validation of an acute kidney injury risk index for patients undergoing general surgery: results from a national data set
    Sachin Kheterpal
    Department of Anesthesiology, University of Michigan Medical School, USA
    Anesthesiology 110:505-15. 2009
    ..The authors sought to identify the incidence, risk factors, and mortality impact of acute kidney injury (AKI) after general surgery using a large and representative national clinical data set...
  22. pmc Urinary biomarkers in the early diagnosis of acute kidney injury
    W K Han
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 73:863-9. 2008
    ..Urinary MMP-9 was not a sensitive marker in the case-control study. Our results suggest that urinary biomarkers allow diagnosis of acute kidney injury earlier than a rise in serum creatinine...
  23. ncbi Mortality after acute renal failure: models for prognostic stratification and risk adjustment
    G M Chertow
    Department of Medicine Research, Division of Nephrology, University of California San Francisco, San Francisco, California, USA
    Kidney Int 70:1120-6. 2006
    ..By incorporating exposures over time, the discriminatory power of predictive models in ARF can be significantly improved...
  24. ncbi The rise of prevalence and the fall of mortality of patients with acute renal failure: what the analysis of two databases does and does not tell us
    Norbert Lameire
    J Am Soc Nephrol 17:923-5. 2006
  25. ncbi Renal blood flow in experimental septic acute renal failure
    C Langenberg
    Department of Nephrology, Charite Campus Mitte, Berlin, Germany
    Kidney Int 69:1996-2002. 2006
    ..05). After 24 h, urine output decreased from 1.4 to 0.3 ml/kg/h (P<0.05). Infusion of E. coli induced hyperdynamic sepsis and ARF. Septic ARF in this setting was associated with a marked increase in RBF and with renal vasodilatation...
  26. ncbi The endothelial cell in ischemic acute kidney injury: implications for acute and chronic function
    D P Basile
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 72:151-6. 2007
    ....
  27. ncbi Phase II, randomized, controlled trial of high-dose N-acetylcysteine in high-risk cardiac surgery patients
    Michael Haase
    Department of Intensive Care, Austin Hospital, University of Melbourne, Australia
    Crit Care Med 35:1324-31. 2007
    ..To assess the effect of high-dose N-acetylcysteine on renal function in cardiac surgery patients at higher risk of postoperative renal failure...
  28. ncbi Acute renal failure and sepsis
    Robert W Schrier
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    N Engl J Med 351:159-69. 2004
  29. doi Epidemiology of acute kidney injury: how big is the problem?
    Eric A J Hoste
    Intensive Care Unit, Ghent University Hospital, Ghent, Belgium
    Crit Care Med 36:S146-51. 2008
    ..Acute kidney injury (AKI) is a complication that occurs frequently in hospitalized patients. In this article, we provide an overview of the literature on the epidemiology of AKI in hospitalized patients...
  30. pmc Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock
    Derek S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Crit Care Med 36:1297-303. 2008
    ..To validate serum neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for acute kidney injury in critically ill children with septic shock...
  31. ncbi Citrate vs. heparin for anticoagulation in continuous venovenous hemofiltration: a prospective randomized study
    Mehran Monchi
    General Intensive Care and Department of Nephrology, University Hospital, 4000 Liege, Belgium
    Intensive Care Med 30:260-5. 2004
    ..To compare the efficacy and safety of adjusted-dose unfractionated heparin with that of regional citrate anticoagulation in intensive care patients treated by continuous venovenous hemofiltration (CVVH)...
  32. ncbi Microvascular endothelial injury and dysfunction during ischemic acute renal failure
    Timothy A Sutton
    Division of Nephrology, Department of Medicine, and the Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Kidney Int 62:1539-49. 2002
    ..This knowledge should provide new diagnostic and therapeutic approaches to ischemic ARF...
  33. ncbi Recent advances in the pathophysiology of ischemic acute renal failure
    Joseph V Bonventre
    Renal Division, Brigham and Women s Hospital, and Department of Medicine, Harvard Medical School, and the Harvard MIT, Division of Health Sciences and Technology, Charlestown, Massachusetts, USA
    J Am Soc Nephrol 14:2199-210. 2003
  34. ncbi Non-specialist management of acute renal failure
    P E Stevens
    Department of Renal Medicine, East Kent Hospitals NHS Trust, Canterbury, UK
    QJM 94:533-40. 2001
    ..A significant proportion of ARF is preventable. Clear guidelines, easily accessible at the point of care, could aid the diagnostic evaluation of the patient with ARF and indicate where referral for a specialist opinion is appropriate...
  35. ncbi Acute renal failure in endotoxemia is caused by TNF acting directly on TNF receptor-1 in kidney
    Patrick N Cunningham
    Section of Nephrology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    J Immunol 168:5817-23. 2002
    ..Therefore, TNF is a key mediator of LPS-induced ARF, acting through its receptor TNFR1 in the kidney...
  36. doi Interleukin-6 mediates lung injury following ischemic acute kidney injury or bilateral nephrectomy
    Christina L Klein
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Kidney Int 74:901-9. 2008
    ..Our study shows that interleukin-6 contributes to lung injury following acute kidney injury...
  37. ncbi Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin (IL)-1beta, IL-18, IL-6, and neutrophil infiltration in the kidney
    Sarah Faubel
    Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, Box C281, 4200 E 9th Ave, Denver, CO 80262, USA
    J Pharmacol Exp Ther 322:8-15. 2007
    ..However, inhibition of IL-1beta, IL-18, and IL-6 or neutrophil infiltration in the kidney is not sufficient to prevent cisplatin-induced ARF...
  38. ncbi Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function
    D P Basile
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Renal Physiol 281:F887-99. 2001
    ..We hypothesize that severe ischemic injury results in a permanent alteration of renal capillary density, contributing to a urinary concentrating defect and the predisposition toward the development of renal fibrosis...
  39. doi Urinary neutrophil gelatinase-associated lipocalin (NGAL) as an early marker of acute kidney injury in critically ill multiple trauma patients
    Konstantinos Makris
    Clinical Biochemistry Department, KAT General Hospital, Kiffissia, Athens, Greece
    Clin Chem Lab Med 47:79-82. 2009
    ..The aim of this study was to evaluate urinary NGAL levels as a predictor of early AKI (first 5 days after injury) in multi-trauma patients...
  40. pmc Intensity of renal support in critically ill patients with acute kidney injury
    Paul M Palevsky
    N Engl J Med 359:7-20. 2008
    ..The optimal intensity of renal-replacement therapy in critically ill patients with acute kidney injury is controversial...
  41. ncbi Gene expression in early ischemic renal injury: clues towards pathogenesis, biomarker discovery, and novel therapeutics
    Prasad Devarajan
    Department of Nephrology, Cincinnati Children s Hospital, Medical Center and Research Foundation, 3333 Burnet Avenue, MLC 7022, Cincinnati, OH 45229 3039, USA
    Mol Genet Metab 80:365-76. 2003
    ..The implications of these findings to the ability of the kidney to repair itself and potential strategies for accelerating recovery are briefly discussed...
  42. ncbi Preventing renal failure in patients with rhabdomyolysis: do bicarbonate and mannitol make a difference?
    Carlos V R Brown
    Department of Surgery, Division of Trauma and Critical Care, University of Southern California and the Los Angeles County Medical Center, Los Angeles, California, USA
    J Trauma 56:1191-6. 2004
    ..The purpose of this study was to determine whether BIC/ MAN is effective in preventing RF in patients with rhabdomyolysis caused by trauma...
  43. doi Costs and outcomes of acute kidney injury (AKI) following cardiac surgery
    Joseph F Dasta
    College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    Nephrol Dial Transplant 23:1970-4. 2008
    ..We determined costs, resource use and mortality rate of patients. We used the serum creatinine component of the RIFLE system to classify AKI...
  44. ncbi Intra-abdominal hypertension and acute renal failure in critically ill patients
    Lidia Dalfino
    Department of Emergency and Organ Transplantation, Anesthesia and Intensive Care Unit, University of Bari, Piazza G Cesare 11, 70124, Bari, Italy
    Intensive Care Med 34:707-13. 2008
    ..To investigate the relationship between intra-abdominal hypertension (IAH) and acute renal failure (ARF) in critically ill patients...
  45. ncbi Biomarkers for the diagnosis and risk stratification of acute kidney injury: a systematic review
    S G Coca
    Clinical Epidemiology Research Center, Veterans Affairs Medical Center, West Haven, Connecticut 06516, USA
    Kidney Int 73:1008-16. 2008
    ..These biomarkers need validation in larger studies, and the generalizability of biomarkers to different types of AKI as well as the incremental prognostic value over traditional clinical variables needs to be determined...
  46. ncbi Kidney NGAL is a novel early marker of acute injury following transplantation
    Jaya Mishra
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Pediatr Nephrol 21:856-63. 2006
    ..We conclude that NGAL staining intensity in early protocol biopsies represents a novel predictive biomarker of acute kidney injury following transplantation...
  47. pmc Clinical review: RIFLE and AKIN--time for reappraisal
    Dinna N Cruz
    Department of Nephrology, Ospedale San Bortolo, Viale Rodolfi 37, 36100 Vicenza, Italy
    Crit Care 13:211. 2009
    ..As new data emerge, integration of novel biomarkers into the consensus definition will be a welcome refinement...
  48. ncbi Acute renal failure in patients with sepsis in a surgical ICU: predictive factors, incidence, comorbidity, and outcome
    Eric A J Hoste
    Intensive Care Unit and Renal Unit, Ghent University Hospital, Gent, Belgium
    J Am Soc Nephrol 14:1022-30. 2003
    ..This model allows initiating specific therapeutic measures earlier in the course of sepsis, hopefully resulting in a lower incidence of ARF and needi for RRT, thereby lowering mortality...
  49. ncbi Pharmacokinetics of clarithromycin in rats with acute renal failure induced by uranyl nitrate
    Ae K Lee
    College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, San 56 1, Shinlim Dong, Kwanak gu, Seoul 151 742, Republic of Korea
    Biopharm Drug Dispos 25:273-82. 2004
    ..This could explain the comparable AUC, Cl and Cl(nr) values of clarithromycin between the two groups of rats...
  50. pmc Case mix, outcome and activity for patients with severe acute kidney injury during the first 24 hours after admission to an adult, general critical care unit: application of predictive models from a secondary analysis of the ICNARC Case Mix Programme data
    Nitin V Kolhe
    Derby City Hospital, Uttoxeter Road, Derby DE22 3NE, UK
    Crit Care 12:S2. 2008
    ....
  51. ncbi Wasp envenomation-induced acute renal failure: a report of three cases
    Sanjay Vikrant
    Department of Nephrology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India
    Nephrology (Carlton) 10:548-52. 2005
    ....
  52. ncbi Association between increases in urinary neutrophil gelatinase-associated lipocalin and acute renal dysfunction after adult cardiac surgery
    Gebhard Wagener
    Department of Anesthesiology, Columbia University, NY 10032 3784, USA
    Anesthesiology 105:485-91. 2006
    ..The authors hypothesized that postoperative urinary NGAL concentrations are increased in adult patients developing ARD after cardiac surgery compared with patients without ARD...
  53. ncbi Downregulation of organic anion transporters in rat kidney under ischemia/reperfusion-induced acute [corrected] renal failure
    T Matsuzaki
    Department of Pharmacy, Kumamoto University Hospital, Kumamoto, Japan
    Kidney Int 71:539-47. 2007
    ..Cobalt treatment has a significant protective effect on ischemia-induced ARF, being accompanied by the restoration of rOAT3 and/or Na(+)/K(+)-ATPase function...
  54. doi Osmotic nephrosis: acute kidney injury with accumulation of proximal tubular lysosomes due to administration of exogenous solutes
    Michael Dickenmann
    Clinic for Transplantation Immunology and Nephrology, University Hospital, Basel, Switzerland
    Am J Kidney Dis 51:491-503. 2008
    ..It has a broad clinical spectrum that includes acute kidney injury and chronic kidney failure in rare cases. This article discusses the pathological characteristics, pathogenesis, and various clinical entities of osmotic nephrosis...
  55. ncbi Pre-renal azotemia: a flawed paradigm in critically ill septic patients?
    Rinaldo Bellomo
    Department of Intensive Care, Austin Hospital, Melbourne, Vic, Australia
    Contrib Nephrol 156:1-9. 2007
    ....
  56. ncbi Apoptotic pathways in ischemic acute renal failure
    Gur P Kaushal
    Department of Medicine, Division of Nephrology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Kidney Int 66:500-6. 2004
    ..It is likely that the cascades that lead to apoptotic or necrotic mode of cell death are activated almost simultaneously and may share some common pathways...
  57. ncbi Epidemiology of acute renal failure: the tip of the iceberg
    Paul M Palevsky
    Clin J Am Soc Nephrol 1:6-7. 2006
  58. ncbi Mortality risk factors and validation of severity scoring systems in critically ill patients with acute renal failure
    Emerson Quintino Lima
    Division of Nephrology, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Ren Fail 27:547-56. 2005
    ..Risk stratification and prediction of outcome in acute renal failure patients in the intensive care unit are important determinants for improvement of patient care and design of clinical trials...
  59. ncbi Outcome in severe acute renal failure associated with malaria
    Rubina Naqvi
    Sindh Institute of Urology and Transplantation, Dow Medical College and Civil Hospital, Karachi, Pakistan
    Nephrol Dial Transplant 18:1820-3. 2003
    ..Malaria, a common health problem in certain parts of the world, has a considerable morbidity and mortality. This study reports its occurrence with a serious complication, acute renal failure (ARF), at a Third World tertiary care centre...
  60. ncbi Renal failure in the ICU: comparison of the impact of acute renal failure and end-stage renal disease on ICU outcomes
    Gilles Clermont
    Department of Critical Care Medicine and Renal Electrolyte Division, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Kidney Int 62:986-96. 2002
    ..We sought to determine the impact of renal dysfunction and/or loss of organ function on outcome...
  61. ncbi Treatment of acute kidney injury: an update on the management of renal replacement therapy
    Helbert Rondon-Berrios
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15240, USA
    Curr Opin Nephrol Hypertens 16:64-70. 2007
    ....
  62. pmc Serum cystatin C concentration as a marker of acute renal dysfunction in critically ill patients
    Patricia Villa
    Intensive Care Unit, Hospital Universitario La Paz, Madrid, Spain
    Crit Care 9:R139-43. 2005
    ..The aim of the present study was to analyze the utility of serum cystatin C as a marker of renal function in these patients...
  63. ncbi Renal dysfunction and serious infections after open-heart surgery
    Charuhas V Thakar
    Department of Nephrology and Hypertension, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Kidney Int 64:239-46. 2003
    ..We studied the influence of preoperative renal function or postoperative acute renal failure (ARF) on the frequency of infections after open-heart surgery...
  64. ncbi Endothelial injury and dysfunction: role in the extension phase of acute renal failure
    Bruce A Molitoris
    Division of Nephrology, Department of Medicine, and the Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 66:496-9. 2004
    ..New diagnostic and therapeutic approaches to ischemic ARF must incorporate these finding to devise early recognition strategies and therapeutic approaches...
  65. pmc Carboxypeptidase G2 rescue in patients with methotrexate intoxication and renal failure
    S Buchen
    Department of Paediatric Haematology Oncology, Children s Medical Hospital, University of Bonn, Bonn, Germany
    Br J Cancer 92:480-7. 2005
    ..In conclusion, administration of CPDG2 is a well-tolerated, safe and a very effective way of MTX elimination in delayed excretion due to renal failure...
  66. ncbi Renal ischemia/reperfusion injury: functional tissue preservation by anti-activated {beta}1 integrin therapy
    Ana Molina
    Hospital Ramon y Cajal, Departamento de Patologia, Carretera de Colmenar, Km 9 1, 28034 Madrid, Spain
    J Am Soc Nephrol 16:374-82. 2005
    ..In conclusion, the data provide evidence that HUTS-21 has a protective effect in renal IRI, preventing tubular epithelial cell detachment by preserving activated beta1 integrins functions...
  67. ncbi Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat
    P K Chatterjee
    The William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, Charterhouse Square, London, England, United Kingdom
    Kidney Int 58:658-73. 2000
    ....
  68. doi Incidence and outcomes of acute kidney injury in intensive care units: a Veterans Administration study
    Charuhas V Thakar
    Nephrology, Cincinnati VA Medical Center, Cincinnati, OH, USA
    Crit Care Med 37:2552-8. 2009
    ..Acute kidney injury in intensive care unit patients is associated with significant mortality...
  69. pmc Acute kidney injury in intensive care unit patients: a comparison between the RIFLE and the Acute Kidney Injury Network classifications
    José António Lopes
    Department of Nephrology and Renal Transplantation, Hospital de Santa Maria, Av, Prof, Egas Moniz, Lisboa 1649 035, Portugal
    Crit Care 12:R110. 2008
    ..We evaluated the incidence of acute kidney injury and compared the ability of the maximum RIFLE and of the maximum AKIN within intensive care unit hospitalization in predicting inhospital mortality of critically ill patients...
  70. ncbi Early hemofiltration improves survival in post-cardiotomy patients with acute renal failure
    Maqsood M Elahi
    Department of Cardiothoracic Surgery, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Eur J Cardiothorac Surg 26:1027-31. 2004
    ..The aim of the present study was to identify how the timing of introduction of hemofiltration affects the morbidity and mortality in patients with ARF after cardiac surgery...
  71. ncbi Hemofiltration and peritoneal dialysis in infection-associated acute renal failure in Vietnam
    Nguyen Hoan Phu
    Center for Tropical Diseases, Center for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Vietnam
    N Engl J Med 347:895-902. 2002
    ..In resource-rich countries, it has been supplanted in recent years by hemodialysis and, most recently, by hemofiltration and associated techniques. The relative efficacy of peritoneal dialysis and hemofiltration is not known...
  72. ncbi Management of crush-related injuries after disasters
    Mehmet Sukru Sever
    Department of Internal Medicine, Istanbul School of Medicine, Istanbul, Turkey
    N Engl J Med 354:1052-63. 2006
  73. ncbi Acute kidney failure: a pediatric experience over 20 years
    Debra M Williams
    Department of Pediatrics, Virginia Commonwealth University, Richmond, USA
    Arch Pediatr Adolesc Med 156:893-900. 2002
    b>Acute kidney failure in children is a catastrophic, life-threatening event.
  74. ncbi Multicenter clinical trial of recombinant human insulin-like growth factor I in patients with acute renal failure
    R Hirschberg
    Harbor UCLA Medical Center, Torrance, California, USA
    Kidney Int 55:2423-32. 1999
    ..Several studies indicate that in rats with ARF caused by ischemia or certain nephrotoxins, insulin-like growth factor-I (IGF-I) enhances the recovery of renal function and suppresses protein catabolism...
  75. ncbi Perioperative renal protection
    Dean R Jones
    Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Best Pract Res Clin Anaesthesiol 22:193-208. 2008
    ..This review will address the definition and diagnosis of AKI, identify patients at risk of AKI, and critically appraise management options for perioperative renal protection...
  76. pmc Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure
    V Y Melnikov
    Department of Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    J Clin Invest 107:1145-52. 2001
    ..Finally, we confirmed histologically that caspase-1(-/-) mice show decreased neutrophil infiltration, indicating that the deleterious role of IL-18 in ischemic ARF may be due to increased neutrophil infiltration...
  77. doi Definition and classification of acute kidney injury
    John A Kellum
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Nephron Clin Pract 109:c182-7. 2008
    ..The RIFLE criteria provide a uniform definition of AKI and have now been validated in numerous studies...
  78. ncbi Acute renal failure in Nigerian children: Port Harcourt experience
    Ifeoma C Anochie
    University of Port Harcourt, PMB 5160, Port Harcourt, Rivers State, Nigeria
    Pediatr Nephrol 20:1610-4. 2005
    ..ARF is a significant cause of mortality in Nigerian children. The patients are not adequately managed because of poverty and lack of facilities for dialysis. The causes of ARF in our environment are preventable, and should be expected...
  79. ncbi Nephrology consultation in acute renal failure: does timing matter?
    Ravindra L Mehta
    Division of Nephrology, Department of Medicine, University of California, San Diego, California, USA
    Am J Med 113:456-61. 2002
    ..The goals of this study were to identify correlates of the timing of nephrology consultation in acute renal failure, and to explore the relation between timing of consultation and outcomes...
  80. ncbi L-arginine deficiency and supplementation in experimental acute renal failure and in human kidney transplantation
    Lothar Schramm
    Department of Medicine, Division of Nephrology, Julius Maximilians University, Wurzburg, Germany
    Kidney Int 61:1423-32. 2002
    ..Thus, we investigated the effects of L-Arg supplementation immediately after kidney transplantation in 54 patients...
  81. ncbi The prognostic importance of a small acute decrement in kidney function in hospitalized patients: a systematic review and meta-analysis
    Steven G Coca
    Clinical Epidemiology Research Center, VA Connecticut Healthcare System, West Haven, USA
    Am J Kidney Dis 50:712-20. 2007
    ..Recently, acute kidney injury defined by small changes in serum creatinine levels was associated with worse short-term outcomes; however, the precision and variability of this association was not fully explored...
  82. ncbi Pharmacologic treatment of acute kidney injury: why drugs haven't worked and what is on the horizon
    Sang Kyung Jo
    Department of Medicine, University of Virginia, Charlottesville, VA, USA
    Clin J Am Soc Nephrol 2:356-65. 2007
    ..Implementation of previous or novel compounds in well-designed clinical trials provides hope for the successful treatment of this devastating disorder...
  83. doi Furosemide does not improve renal recovery after hemofiltration for acute renal failure in critically ill patients: a double blind randomized controlled trial
    Peter H J van der Voort
    Department of Intensive Care, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
    Crit Care Med 37:533-8. 2009
    ..To study the potential beneficial role of furosemide in resolving renal failure after hemofiltration in mechanically ventilated critically ill patients...
  84. doi Impact of minimal increases in serum creatinine on outcome in patients after cardiothoracic surgery: do we have to revise current definitions of acute renal failure?
    Andrea Lassnigg
    Department of Cardiothoracic and Vascular Anesthesia and Intensive Care Medicine, University Hospital of Vienna, A 1090 Vienna, Austria
    Crit Care Med 36:1129-37. 2008
    ....
  85. doi Acute kidney injury in patients with sepsis: a contemporary analysis
    José António Lopes
    Department of Nephrology and Renal Transplantation, Hospital de Santa Maria, Av Prof Egas Moniz, 1649 035, Lisbon, Portugal
    Int J Infect Dis 13:176-81. 2009
    ....
  86. ncbi Insulin resistance in critically ill patients with acute renal failure
    Seema Basi
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
    Am J Physiol Renal Physiol 289:F259-64. 2005
    ..Insulin resistance as defined by hyperglycemia in the setting of higher insulin concentrations may be associated with mortality in critically ill patients with ARF. The IGF-IGFBP axis may play an important role in this process...
  87. ncbi Incidence, classification, and outcomes of acute kidney injury
    Eric A J Hoste
    Intensive Care Unit, Ghent University Hospital, Ghent, Belgium
    Contrib Nephrol 156:32-8. 2007
    ..Recent data emphasized the importance of less severe impairment of kidney function, hence the terminology acute kidney injury (AKI) was introduced...
  88. ncbi Acute kidney injury prediction following elective cardiac surgery: AKICS Score
    H Palomba
    Nephrology Division, Acute Renal Failure Group, Heart Institute, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    Kidney Int 72:624-31. 2007
    ..The AKICS system that we developed, which incorporates five risk categories, accurately predicts AKI following cardiac surgery...
  89. ncbi Early detection of acute renal failure by serum cystatin C
    Stefan Herget-Rosenthal
    Department of Nephrology, Thoracic and Cardiovascular Surgery, University Hospital, Essen, Germany
    Kidney Int 66:1115-22. 2004
    ..However, serum creatinine, the standard marker to detect ARF, demonstrates major limitations. We prospectively evaluated whether serum cystatin C detected ARF earlier than serum creatinine...
  90. ncbi The outcome of acute renal failure in the intensive care unit according to RIFLE: model application, sensitivity, and predictability
    Nihal Y Abosaif
    Sheffield Kidney Institute and Intensive Care Unit, Northern General Hospital, University of Sheffield, UK
    Am J Kidney Dis 46:1038-48. 2005
    ....
  91. doi Urinary NGAL in premature infants
    Adrian P Lavery
    Division of Neonatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Pediatr Res 64:423-8. 2008
    ..We conclude that urine NGAL is easily obtained in premature infants and that it correlates significantly with both BW and gestational age. The use of urinary NGAL as a biomarker of AKI in premature infants warrants further investigation...
  92. ncbi Contrast-induced nephropathy
    Peter A McCullough
    Department of Medicine, Division of Cardiology, William Beaumont Hospital, 4949 Coolidge, Royal Oak, MI 48073, USA
    Crit Care Clin 21:261-80. 2005
    ..5 mg/dL) can be predicted by using multivariate tools. Prevention measures include adequate hydration, use of N-acetylcysteine and iso-osmolar contrast, and for patients who are at the highest risk, prophylactic hemofiltration...
  93. ncbi Biomarkers of acute renal injury and renal failure
    Ronald J Trof
    Department of Intensive Care, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Shock 26:245-53. 2006
    ..Large prospective studies in human are needed to demonstrate an improved outcome of biomarker-driven management of the patient at risk for ARF...
  94. ncbi Platelet loss across the hemofilter during continuous hemofiltration
    J Mulder
    Department of Intensive Care, Austin Hospital, Melbourne, Australia
    Int J Artif Organs 26:906-12. 2003
    ..Thrombocytopenia is a common finding in patients in the intensive care unit receiving continuous renal replacement therapy (CRRT). It is unknown if the hemofilter itself contributes to the platelet loss...
  95. ncbi The changing epidemiology of acute renal failure
    Norbert Lameire
    Ghent University, Ghent, Belgium
    Nat Clin Pract Nephrol 2:364-77. 2006
    ....
  96. ncbi Nitric oxide in acute renal failure: NOS versus NOS
    Michael S Goligorsky
    Department of Medicine, State University of New York, Stony Brook, NY 11794 8152, USA
    Kidney Int 61:855-61. 2002
    ....
  97. ncbi Endotoxemic renal failure in mice: Role of tumor necrosis factor independent of inducible nitric oxide synthase
    M Knotek
    Department of Medicine, Division of Renal Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Kidney Int 59:2243-9. 2001
    ..The present study tested the hypothesis that the role of TNF in endotoxic renal failure is mediated by iNOS-derived NO...
  98. ncbi Kidney dysfunction in the postoperative period
    J W Sear
    Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK
    Br J Anaesth 95:20-32. 2005
    ....
  99. pmc The local and systemic inflammatory transcriptome after acute kidney injury
    Dmitry N Grigoryev
    Division of Allergy and Clinical Immunology, 5501 Hopkins Bayview Circle, JHAAC 3A 62, Baltimore, Maryland, 21224, USA
    J Am Soc Nephrol 19:547-58. 2008
    ..Functional genomic analysis identified potential mediators that connect local and systemic inflammation, suggesting that this type of analysis may be a useful discovery tool for novel biomarkers and therapeutic drug development...
  100. ncbi The Prospective Pediatric Continuous Renal Replacement Therapy (ppCRRT) Registry: design, development and data assessed
    S L Goldstein
    Baylor College of Medicine, Houston, Texas, USA
    Int J Artif Organs 27:9-14. 2004
    ....
  101. ncbi Early renal replacement therapy in patients with postoperative acute liver failure associated with acute renal failure: effect on postoperative outcomes
    Vin Cent Wu
    Department of Internal Medicine, Yun Lin branch, National Taiwan University, Taipei, Taiwan
    J Am Coll Surg 205:266-76. 2007
    ..The optimal time to initiate renal replacement therapy for acute renal failure is controversial because of the poor overall clinical outcomes...

Research Grants63

  1. Improving Kidney Transplant Outcome with a Novel Complement Inhibitor
    SHELLEY MAVES; Fiscal Year: 2007
    ..Delayed Graft Function (DGF) is a form of acute kidney failure that occurs in up to 50% of transplants and relates directly to graft performance and patient outcome...
  2. Structure Based design of Meprin A Inhibitors for Acute Nephropathy
    Kal Ramnarayan; Fiscal Year: 2007
    ..in cultured cells and live rodents suggest that meprin A activity plays a key role in the etiology of acute kidney failure. This deadly disease affects over 250,000 Americans each year, with a 60% death rate...
  3. Endothelial Injury in Endotoxin-Induced Acute Renal Failure
    Patrick N Cunningham; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Acute kidney failure (ARF) is a common complication in hospitalized patients that leads to great morbidity and mortality, and ..
  4. Relative Roles of HSP70 and HSP25 in the Modulation of Renal Injury
    Rajasree Sreedharan; Fiscal Year: 2010
    ..The proposed studies will help understand the molecular processes involved in acute kidney failure and recovery...
  5. Histone Acetyl Transferase HBO1 in kidney epithelial cell cycle
    Maria V Panchenko; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Ischemia and reperfusion is a leading cause of acute kidney failure. Proximal tubular epithelial cells are most sensitive to this stress...
  6. Pathogenicity of Shiga Toxin Producing E.coli
    ALISON DAVIS O'BRIEN; Fiscal Year: 2013
    ..Moreover, the hemolytic uremic syndrome (HUS), a sequela of STEC infection, is the most frequent basis for acute kidney failure in U.S. children...
  7. A Transdisciplinary Approach to Engage Specialty Investigators in Aging Research
    Kevin P High; Fiscal Year: 2013
    ..Professors (ASP) has previously held five similar conferences (on topics such as HIV and aging and acute kidney failure in elderly patients) and aims to extend this series with NIH funding supplemented and leveraged by private ..
  8. Acute Kidney Failure in a Cancer ICU
    Joshua A Samuels; Fiscal Year: 2010
    ..independent clinical investigator, and to gain important knowledge regarding the development and outcome of acute kidney failure (AKF)...
  9. Localization of cisplatin and cisplatin-binding proteins in the inner ear
    Peter S Steyger; Fiscal Year: 2010
    ..However, it is ototoxic, neurotoxic and nephrotoxic, causing permanent deafness and acute kidney failure in patients treated with these drugs...
  10. Identification of novel genes regulating metalloproteinase activity
    Andreas Herrlich; Fiscal Year: 2009
    ..As example, acute kidney failure and heart failure still have a very high mortality despite years of clinical and basic research...
  11. Pathophysiology of sepsis-induced renal injury
    Pierre C Dagher; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Acute kidney failure and sepsis represent a major healthcare burden in the US with a cost exceeding millions of dollars yearly.
  12. Rho GTPases and Actin Cytoskeletal Function in Renal Ischemia
    Simon J Atkinson; Fiscal Year: 2012
    ..Narrative Ischemia (loss of blood flow) is a major cause of acute kidney failure. Currently there is a poor understanding of the way that kidney cells respond to ischemia, which makes it ..
  13. PREVENTING CONTRAST-INDUCED NEPHROPATHY
    Ali Hassan; Fiscal Year: 2009
    ..agents are toxic to the kidney, and exposure can lead to contrast induced nephropathy (CIN), a form of acute kidney failure, in patients with pre-existing renal insufficiency...
  14. Pathogenicity of Shiga Toxin-Producing E. coli
    ALISON O BRIEN; Fiscal Year: 2007
    ..the hemolytic uremic syndrome (HUS), a sequela of O 157:H7 infection, is the most frequent basis for acute kidney failure in U.S. children...
  15. Biological Markers of Recovery for the Kidney
    John A Kellum; Fiscal Year: 2010
    ..For analyses requiring serial samples and urine samples, we propose to study a subset of trial patients enrolled at 5 sites who consent to additional sample collection (208 patients) ..
  16. Systems Engineering of Pheresis Intervention for Sepsis
    John Kellum; Fiscal Year: 2009
    ..We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.). ..
  17. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  18. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  19. TWO NOVEL CPLA2 BINDING PROTEINS AND CELL DEATH
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2010
    ..Given the large number of patients that are initiated on dialysis each year, this addresses a critical public health problem. ..
  20. PREDICTING AND IMPROVING OUTCOMES IN ACUTE RENAL FAILURE
    Ravindra Mehta; Fiscal Year: 2001
    ..It is anticipated (by the applicants) that information gained from this study, being largely observational, will be used to rationally design intervention strategies in future years. ..
  21. Non-Invasive Optical Determination of GFR
    Bruce Molitoris; Fiscal Year: 2008
    ..This has limited the ability to effectively test potential new therapies. PharmacoPhotonics, LLC is developing a non-invasive optical technique to meet this need. [unreadable] [unreadable] [unreadable]..
  22. Linking acute, chronic and end-stage renal disease
    Chi yuan Hsu; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  23. Ischemia-induced Actin Cytoskeletal Alterations
    Bruce Molitoris; Fiscal Year: 2008
    ..abstract_text> ..
  24. RAB5 AND PI-3-KINASE AND GENTAMICIN TOXICITY
    Bruce Molitoris; Fiscal Year: 2002
    ..By performing these studies, it is hoped that formulation of specific therapies to delay and/or inhibit this toxicity will become possible. ..
  25. TGF BETA EXPRESSION FOLLOWING ISCHEMIC ACUTE RENAL FAIL
    DAVID BASILE; Fiscal Year: 2002
    ..abstract_text> ..
  26. CRIC-Plus: Study of Advanced Chronic Renal Insufficiency
    Chi yuan Hsu; Fiscal Year: 2010
    ..Aim #4: To study the effect of chronic renal insufficiency management, including the timing of dialysis initiation, on clinical outcomes after onset of end-stage renal disease. ..
  27. Consequences of Chronic Renal Insufficiency
    Chi yuan Hsu; Fiscal Year: 2006
    ..These will contribute greatly to my development into an independent investigator. ..
  28. Center for Advanced Renal Microscopic Analysis
    Bruce Molitoris; Fiscal Year: 2006
    ..The research development and support activities of the imaging facility are expected to provide numerous opportunities to impact the understanding of renal disease processes and therapeutic interventions. ..
  29. Continuation of Dialysis Access Consortium Clinical Trials
    Jonathan Himmelfarb; Fiscal Year: 2007
    ..The health care cost o maintaining adequate vascular access should also decrease from its current rate of over one billion dollars per year. ..
  30. Kim-1 in Renal Epithelial Cell Motility and Adhesion
    BENJAMIN HUMPHREYS; Fiscal Year: 2005
    ..The proposed studies will have great relevance in understanding the molecular mechanisms of renal regeneration and renal cell cancer invasion and metastasis. ..
  31. Role of Myosin II in Ischemic Acute Renal Failure
    Timothy Sutton; Fiscal Year: 2006
    ..Mutant forms of MLCK and ROCK proteins will be co-expressed in MDCK cells to alter cellular signaling. ..
  32. PREVENTION OF VASCULOPATHY AND NEPHROPATHY IN METABOLIC SYNDROME
    Michael S Goligorsky; Fiscal Year: 2010
    ..abstract_text> ..
  33. INTEGRINS IN ACUTE RENAL FAILURE
    MICHAEL GOLIGORSKY; Fiscal Year: 2002
    ....
  34. Hospital and Community Acquired Acute Renal Failure
    Glenn Chertow; Fiscal Year: 2006
    ..This study will efficiently inform the Nephrology community by providing a foundation of fundamental information (ARF definitions, incidence, consequences and costs) upon which a clinical trials network can be built. ..
  35. The Role of IL-18 in Ischemic Acute Renal Failure
    Sarah Faubel; Fiscal Year: 2007
    ..The results of these experiments will contribute to the understanding of the pathogenesis of ischemic ARF, as well as ischemia in other organs. ..
  36. Endothelial dysfunction in acute renal ischemia
    MICHAEL GOLIGORSKY; Fiscal Year: 2007
    ..Number of publicationsand manuscriptsacceptedfor publication (not to exceed 10) 10 Other items (list): 1. Color illustrations from the grant application 2. Movies - intravital videomicroscopy supplement ..
  37. Effects of Vasoactive Drugs on Perfusion in Septic Shock
    Patrick Murray; Fiscal Year: 2005
    ..focusing on prevention and management of septic acute renal failure, as a surrogate endpoint to optimize systemic perfusion in hyperdynamic states. ..
  38. Renal Injury After Hematopoietic Stem Cell Transplant
    Sangeeta Hingorani; Fiscal Year: 2007
    ..host disease and cyclopsorine use using Cox regression modeling. ..
  39. Novel epoxide hydrolase inhibitor for stroke prevention
    JOHN IMIG; Fiscal Year: 2005
    ..In the Phase II work, Arete Therapeutics will use the collected information to progress toward clinical trials in the area of stroke and possible new therapeutic avenues. ..
  40. RAE 1 and renal injury
    Christopher Lu; Fiscal Year: 2004
    ..The "RAE 1 - NKG2D vicious cycle" proposed here would be a novel insight into progressive renal injury. New therapy might be directed at interdicting this vicious cycle. ..
  41. MMP-9-Dependent Vessel Wall Remodeling is NO-Dependent
    Gilbert Upchurch; Fiscal Year: 2005
    ....
  42. TLR4 and murine ischemic acute renal failure
    Christopher Y Lu; Fiscal Year: 2010
    ..Altogether, this is a novel approach to ischemic ARF and may yield new insights and therapies of a disease that continues, despite modern therapy, to have a high mortality. ..
  43. Maximize RAS Blockade in Diabetic Nephropathy
    Timothy Meyer; Fiscal Year: 2003
    ..But the number of such trials which can be performed is limited. Short term trials, such as those described in this proposal, are urgently required to help identify treatment regimens which merit further, longer term study. ..
  44. Pheresis Treatment of Bioterrorism-Induced Sepsis
    Stephen Ash; Fiscal Year: 2005
    ..The safety systems of the existing PF system will be modified to meet the needs of the stand-alone system. Finally, an animal model of sepsis will be used to check efficacy and safety of the entire system. ..
  45. Brief Intervention to Reduce Alcohol Use in ED patients
    William Fernandez; Fiscal Year: 2004
    ..e. routine care). ..
  46. Functional Studies of VHL by Conditional Gene Targeting
    Volker Haase; Fiscal Year: 2003
    ..Volker H. Haase, who is an Assistant Professor of Medicine in the University of Pennsylvania's Renal Division. Dr. Michael Madaio, Professor of Medicine, will function as Dr. Haase's mentor for this grant. ..
  47. MOLECULAR REGULATION OF ENDOTHELIAL NA K 2CL COTRANSPORT
    W O NEILL; Fiscal Year: 2002
    ..abstract_text> ..
  48. Intervention to Increase Safety Belt Use in ED Patients
    William Fernandez; Fiscal Year: 2005
    ..e. the "teachable moment"). ..
  49. Bone Health in Pediatric Crohn Disease: A Low Magnitude Mechanical Stimulus Trial
    MARY BETH LEONARD; Fiscal Year: 2010
    ..The NIH Osteoporosis Consensus Statement called for studies to identify interventions that promote bone health in children at risk. LMMS may provide a safe and effective treatment for myriad chronic pediatric diseases. ..
  50. STRUCTURAL EFFECTS OF RENAL OSTEODYSTROPHY DURING GROWTH
    Mary Leonard; Fiscal Year: 2006
    ....
  51. Removal of Protein-Bound Solutes by Dialysis
    Timothy Meyer; Fiscal Year: 2007
    ..The proposed ancillary study to the FHN will provide a unique opportunity to relate protein-bound solute levels to other chemical parameters and indices of well-being in a large group of hemodialysis patients. ..
  52. Complement Activation and Renal Ischemia/Reperfusion Injury
    JOSHUA THURMAN; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  53. Low Magnitude Mechanical Stimuli Effects on Bone Structu
    Mary Leonard; Fiscal Year: 2006
    ..Consistent with the Program Announcement, it is anticipated that this innovative study will lead to a full-scale clinical trial of LMMS as an anabolic bone therapy for ROD in dialysis patients. ..
  54. Acute renal failure after whole body ischemia
    Hamid Rabb; Fiscal Year: 2008
    ..Our long-term goals are to develop a clinically relevant experimental model which can be used to develop novel therapies for ARF. [unreadable] [unreadable] [unreadable]..
  55. Role of Inter-alpha Inhibitors in Anthrax Intoxication
    Steven Opal; Fiscal Year: 2007
    ..Our research is focused on the development of a new and safe treatment based on the ability of inter-alpha proteins to prevent the fatal consequences of anthrax infection. [unreadable] [unreadable] [unreadable] [unreadable]..
  56. T cell modulation of renal ischemia reperfusion injury.
    Hamid Rabb; Fiscal Year: 2009
    ..The long term goal will be to identify the antigens and molecular pathways that fuel the injury processes in renal IRI, and develop targeted immune therapies for ARF. ..
  57. Vitamin D Deficiency, Physical Performance and Cardiovascular Outcomes in CRIC
    Mary Leonard; Fiscal Year: 2009
    ..Delineation of the relations between 25(OH)D and 1,25(OH)2D and clinical outcomes is necessary in order to develop anticipated randomized trials of vitamin D supplementation in CRI. ..
  58. Endonuclease dificiency in breast cancer progression
    Alexei Basnakian; Fiscal Year: 2006
    ..The next specific aim will be focused on functional studies to determine the role of EndoG in dedifferentiation and invasiveness of breast cancer cells in vitro (Specific Aim 2). ..
  59. Pyrophosphate in vascular calcification of renal failure
    W CHARLES O apos NEILL; Fiscal Year: 2010
    ..The results will establish a new paradigm for vascular calcification in renal failure and form the basis for important clinical trials in humans. ..
  60. Quantifying Left Ventricular Ejection Effectiveness
    Michael Pinsky; Fiscal Year: 2007
    ..The ultimate goal of this proposal is to develop and validate an echocardiographic-based algorithm that quantifies LV ejection effectiveness by merging both power and synchrony of contraction into a common metric. ..
  61. Tumor necrosis factor in cisplatin nephrotoxicity
    William Reeves; Fiscal Year: 2008
    ..Finally, these results are expected to have significance not only to cisplatin nephrotoxicity, but also to other forms of acute and chronic kidney disease. ..
  62. MECHANISMS OF RENAL TUBULAR EPITHELIAL CELL INJURY
    Sudhir Shah; Fiscal Year: 2005
    ..abstract_text> ..