kidney failure

Summary

Summary: A severe irreversible decline in the ability of kidneys to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal failure, either acute (KIDNEY FAILURE, ACUTE) or chronic (KIDNEY FAILURE, CHRONIC), requires HEMODIALYSIS.

Top Publications

  1. ncbi Serum cystatin C as a new marker for noninvasive estimation of glomerular filtration rate and as a marker for early renal impairment
    E Coll
    Services of Nephrology, Biochemistry, Statistics, and Nuclear Medicine, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, University of Barcelona, Spain
    Am J Kidney Dis 36:29-34. 2000
  2. doi Notch inhibition reverses kidney failure
    Matthias Kretzler
    Nat Med 14:246-7. 2008
  3. ncbi CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin
    Vanja Karamatic Crew
    Bristol Institute for Transfusion Sciences, Southmead Road, Bristol, BS10 5ND, United Kingdom
    Blood 104:2217-23. 2004
  4. ncbi Mechanisms of Disease: erythropoietin resistance in patients with both heart and kidney failure
    Karien van der Putten
    Department of Internal Medicine, Meander Medical Center, Amersfoort, The Netherlands
    Nat Clin Pract Nephrol 4:47-57. 2008
  5. pmc Kidney failure in mice lacking the tetraspanin CD151
    Norman Sachs
    Division of Cell Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands
    J Cell Biol 175:33-9. 2006
  6. ncbi Renal insufficiency in long-term lithium treatment
    Elie Lepkifker
    Lithium Clinic, Psychiatric Division, Chaim Sheba Medical Center, Tel Hashomer, Israel
    J Clin Psychiatry 65:850-6. 2004
  7. ncbi De novo Uroplakin IIIa heterozygous mutations cause human renal adysplasia leading to severe kidney failure
    Dagan Jenkins
    Nephro Urology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1E 1EH, UK
    J Am Soc Nephrol 16:2141-9. 2005
  8. ncbi Cardio-ankle vascular index and ankle pulse wave velocity as a marker of arterial fibrosis in kidney failure treated by hemodialysis
    Atsuhiro Ichihara
    Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Kidney Dis 52:947-55. 2008
  9. ncbi Enoxaparin vs. unfractionated heparin for anticoagulation during continuous veno-venous hemofiltration: a randomized controlled crossover study
    Michael Joannidis
    Medical University Innsbruck, Division of General Internal Medicine, Department of Internal Medicine, Medical Intensive Care Unit, Anichstrasse 35, 6020 Innsbruck, Austria
    Intensive Care Med 33:1571-9. 2007
  10. ncbi [Gadolinium-induced systemic fibrosis in advanced kidney failure]
    A Rodriguez Jornet
    Servicio de Nefrologia, Corporación Sanitaria Parc Taulí, Sabadell
    Nefrologia 29:358-63. 2009

Detail Information

Publications258 found, 100 shown here

  1. ncbi Serum cystatin C as a new marker for noninvasive estimation of glomerular filtration rate and as a marker for early renal impairment
    E Coll
    Services of Nephrology, Biochemistry, Statistics, and Nuclear Medicine, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, University of Barcelona, Spain
    Am J Kidney Dis 36:29-34. 2000
    ....
  2. doi Notch inhibition reverses kidney failure
    Matthias Kretzler
    Nat Med 14:246-7. 2008
  3. ncbi CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin
    Vanja Karamatic Crew
    Bristol Institute for Transfusion Sciences, Southmead Road, Bristol, BS10 5ND, United Kingdom
    Blood 104:2217-23. 2004
    ....
  4. ncbi Mechanisms of Disease: erythropoietin resistance in patients with both heart and kidney failure
    Karien van der Putten
    Department of Internal Medicine, Meander Medical Center, Amersfoort, The Netherlands
    Nat Clin Pract Nephrol 4:47-57. 2008
    ..Furthermore, neocytolysis could have a role. As resistance to exogenous EPO is associated with an increased risk of death, it is important to understand how cardiorenal failure affects EPO production and function...
  5. pmc Kidney failure in mice lacking the tetraspanin CD151
    Norman Sachs
    Division of Cell Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands
    J Cell Biol 175:33-9. 2006
    ..Patients with a nonsense mutation in CD151 display end-stage kidney failure associated with regional skin blistering and sensorineural deafness, and mice lacking the integrin alpha3 ..
  6. ncbi Renal insufficiency in long-term lithium treatment
    Elie Lepkifker
    Lithium Clinic, Psychiatric Division, Chaim Sheba Medical Center, Tel Hashomer, Israel
    J Clin Psychiatry 65:850-6. 2004
    ..To compare long-term lithium patients who developed renal insufficiency (RI) with those who did not, and to examine what characterized these groups...
  7. ncbi De novo Uroplakin IIIa heterozygous mutations cause human renal adysplasia leading to severe kidney failure
    Dagan Jenkins
    Nephro Urology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1E 1EH, UK
    J Am Soc Nephrol 16:2141-9. 2005
    ..De novo heterozygous mutations in Uroplakin IIIa (UPIIIa) are reported in four of 17 children with kidney failure caused by renal adysplasia in the absence of an overt urinary tract obstruction...
  8. ncbi Cardio-ankle vascular index and ankle pulse wave velocity as a marker of arterial fibrosis in kidney failure treated by hemodialysis
    Atsuhiro Ichihara
    Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Kidney Dis 52:947-55. 2008
    Patients with kidney failure treated with hemodialysis have a high incidence of cardiovascular diseases caused by accelerated arteriosclerosis. However, accurate evaluation of the extent of arteriosclerosis is difficult...
  9. ncbi Enoxaparin vs. unfractionated heparin for anticoagulation during continuous veno-venous hemofiltration: a randomized controlled crossover study
    Michael Joannidis
    Medical University Innsbruck, Division of General Internal Medicine, Department of Internal Medicine, Medical Intensive Care Unit, Anichstrasse 35, 6020 Innsbruck, Austria
    Intensive Care Med 33:1571-9. 2007
    ..The purpose of this study was to evaluate the efficacy and safety of the low molecular weight heparin enoxaparin as anticoagulant in continuous veno-venous hemofiltration (CVVH) compared with unfractionated heparin...
  10. ncbi [Gadolinium-induced systemic fibrosis in advanced kidney failure]
    A Rodriguez Jornet
    Servicio de Nefrologia, Corporación Sanitaria Parc Taulí, Sabadell
    Nefrologia 29:358-63. 2009
    ..The patient had repeated exposure to gadodiamide; it increases the possibility of the systemic fibrosis. We review the recent literature of the nephrogenic systemic fibrosis...
  11. ncbi Therapy of anemia in kidney failure, using plasmid encoding erythropoietin
    Peggy Richard-Fiardo
    INSERM, U533, Nantes F 44035, France
    Hum Gene Ther 19:331-42. 2008
    ....
  12. pmc Shiga toxin-producing Escherichia coli-associated kidney failure in a 40-year-old patient and late diagnosis by novel bacteriologic and toxin detection methods
    Louise D Teel
    Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Clin Microbiol 41:3438-40. 2003
    Infection with Shiga toxin-producing Escherichia coli (STEC) is the most common cause of kidney failure in children. High morbidity is also associated with infections in the elderly...
  13. ncbi Octreotide therapy for recurrent refractory hypoglycemia due to sulfonylurea in diabetes-related kidney failure
    Rita R Gonzalez
    New York University School of Medicine, New York 10016, USA
    Endocr Pract 13:417-23. 2007
    ....
  14. ncbi Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure
    R Birkenhäger
    University Children s Hospital, Freiburg University, D 79106 Freiburg, Germany
    Nat Genet 29:310-4. 2001
    ..The gene encodes a hitherto unknown protein with two putative transmembrane alpha-helices and thus might function as a regulator for ion-transport proteins involved in aBS, or else as a new transporter or channel itself...
  15. ncbi Renal insufficiency and subsequent death resulting from cardiovascular disease in the United States
    Paul Muntner
    Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112, USA
    J Am Soc Nephrol 13:745-53. 2002
    ..This study indicates that, in a representative sample of the United States general population, renal insufficiency is independently associated with increased cardiovascular disease-related and all-cause mortality rates...
  16. ncbi Prospective randomized trial to assess caloric and protein needs of critically Ill, anuric, ventilated patients requiring continuous renal replacement therapy
    C D Scheinkestel
    Department of Intensive Care, Alfred Hospital, Melbourne, Australia, Australia
    Nutrition 19:909-16. 2003
    ..We also determined whether these feeding regimes affected patient outcome...
  17. ncbi Impact of increasing parenteral protein loads on amino acid levels and balance in critically ill anuric patients on continuous renal replacement therapy
    C D Scheinkestel
    Alfred Hospital, Melbourne, Australia
    Nutrition 19:733-40. 2003
    ....
  18. ncbi [The start of renal replacement therapy in a Spanish department]
    I Castellano
    Servicio de Nefrologia, Hospital San Pedro de Alcantara, Caceres
    Nefrologia 26:445-51. 2006
    ..The aim of our study was to analyse patient clinical and analytic characteristics at the time of initiating dialysis and to evaluate if morbimortality was affected by planned start...
  19. ncbi Diclofenac residues as the cause of vulture population decline in Pakistan
    J Lindsay Oaks
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, USA
    Nature 427:630-3. 2004
    ..We propose that residues of veterinary diclofenac are responsible for the OWBV decline...
  20. ncbi Renal impact of fluid management with colloids: a comparative review
    I J Davidson
    The University of Texas Southwestern Medical Center at Dallas, Division of Surgical Transplantation, Dallas, Texas 75390, USA
    Eur J Anaesthesiol 23:721-38. 2006
    ..Colloids such as hydroxyethyl starch (HES), gelatin, dextran and albumin are useful for maintaining renal perfusion and function. The comparative renal effects of colloids have not been previously reviewed...
  21. pmc Cystatin C and beta2-microglobulin: markers of glomerular filtration in critically ill children
    José David Herrero-Morín
    Hospital Universitario Central de Asturias, University of Oviedo, Julian Claveria Street, 33006, Oviedo, Spain
    Crit Care 11:R59. 2007
    ..The aim of the present study was to analyse the utility of serum cystatin C and beta2-microglobulin (B2M) in detecting decreased glomerular filtration rate in critically ill children...
  22. ncbi Acute cardio-renal syndrome: progression from congestive heart failure to congestive kidney failure
    Detlef Wencker
    Department of Medicine, Section of Cardiovascular Disease, Yale University School of Medicine, 135 College Street, Suite 301, New Haven, CT 06510, USA
    Curr Heart Fail Rep 4:134-8. 2007
    ....
  23. ncbi The effect of renal insufficiency on workforce participation in the United States: an analysis using National Health and Nutrition Examination Survey III data
    Scott Klarenbach
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Am J Kidney Dis 40:1132-7. 2002
    ..End-stage renal disease is associated with workforce nonparticipation, but no previous study has assessed the impact of renal insufficiency on employment status from a population standpoint...
  24. ncbi Kidney failure following liver resection
    F Saner
    Universitatsklinikum Essen, Klinik fUr Allgemein, Viszeral und Transplantationschirurgie, Essen, Germany
    Transplant Proc 40:1221-4. 2008
    ..Acute kidney failure correlates well with mortality...
  25. ncbi Improvement of kidney failure with fetal kidney precursor cell transplantation
    Sang Soo Kim
    Department of Bioengineering, Hanyang University, Seoul, Korea
    Transplantation 83:1249-58. 2007
    ..Here, we show that the transplantation of fetal kidney precursor cells reconstitutes kidney tissues, reduces uremic symptoms, and provides life-saving metabolic support in kidney failure animal models.
  26. ncbi Carboplatin-based chemotherapy in patients with gynecological malignancies on long-term hemodialysis
    Hitoshi Niikura
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Anticancer Drugs 14:735-8. 2003
    ..Our findings suggest these regimens are feasible, and the combination of paclitaxel and carboplatin is effective chemotherapy when administered to long-term hemodialysis patients with recurrent endometrial carcinoma...
  27. ncbi Evaluation of renal function in intensive care: plasma cystatin C vs. creatinine and derived glomerular filtration rate estimates
    Thierry Le Bricon
    Laboratoire de Biochimie A, Hôpital St Louis AP HP, 1 avenue Claude Vellefaux, 75010 Paris, France
    Clin Chem Lab Med 43:953-7. 2005
    ..In intensive care unit surgical adult patients, CG CrCl provides an easy and cost-effective estimate of GFR. Superior to creatinine, plasma cystatin C can be measured in selected patients where CG CrCl is known to be inaccurate...
  28. ncbi Impact of renal insufficiency on short- and long-term outcomes after cardiac surgery
    Charmaine E Lok
    Institute for Clinical Evaluative Sciences and the University of Toronto, Toronto, Ontario, Canada
    Am Heart J 148:430-8. 2004
    ..This population-based study aimed to determine the risk of nondialysis dependent renal insufficiency (RI) on the long-term outcomes of patients who undergo CABG...
  29. pmc Association of polymorphisms in monocyte chemoattractant protein-1 promoter with diabetic kidney failure in Korean patients with type 2 diabetes mellitus
    Ju Young Moon
    Department of Nephrology, College of Medicine, Kyunghee University, Seoul, Korea
    J Korean Med Sci 22:810-4. 2007
    ..We investigated the association of the -2518 A/G polymorphism in the MCP-1 gene with progressive kidney failure in Korean patients with type 2 diabetes mellitus (DM)...
  30. ncbi The impact of protein intake on renal function decline in women with normal renal function or mild renal insufficiency
    Eric L Knight
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Ann Intern Med 138:460-7. 2003
    ..However, the long-term impact of protein intake on renal function in persons with normal renal function or mild renal insufficiency is unknown...
  31. ncbi Elderly medical patients treated with prophylactic dosages of enoxaparin: influence of renal function on anti-Xa activity level
    Isabelle Mahe
    Internal Medicine Department A, Lariboisiere Hospital, Paris, France
    Drugs Aging 24:63-71. 2007
    ..The safety and optimal use of prophylactic treatment with low-molecular-weight heparins in elderly patients with impaired renal function remain undefined...
  32. ncbi Laparoscopic cyst decortication in autosomal dominant polycystic kidney disease: impact on pain, hypertension, and renal function
    David I Lee
    Department of Surgery, Division of Urologic Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    J Endourol 17:345-54. 2003
    ..We present our 7-year experience with LCD for ADPKD with regard to pain relief, hypertension, and renal function...
  33. ncbi An analysis of the association between preoperative renal dysfunction and outcome in cardiac surgery: estimated creatinine clearance or plasma creatinine level as measures of renal function
    Feng Wang
    Department of Anesthesia, University of Ottawa Heart Institute, Ottawa, ON, Canada
    Chest 124:1852-62. 2003
    ..This study compared creatinine clearance (ClCr), estimated from the Cockroft and Gault formula, and plasma creatinine level as predictors of outcome after cardiac surgery...
  34. ncbi Urinary proteins in multiple myeloma: correlation with clinical parameters and diagnostic implications
    A Corso
    Institute of Hematology, IRCCS Policlinico San Matteo, University of Pavia, 27100, Pavia, Italy
    Ann Hematol 82:487-91. 2003
    ....
  35. ncbi Gender differences in predictors of the decline of renal function in the general population
    Nynke Halbesma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 74:505-12. 2008
    ..These studies show that there are gender differences in the standard predictors of the decline in renal function...
  36. ncbi Renal insufficiency as a predictor of adverse events and mortality after renal artery stent placement
    David J Kennedy
    Department of Medicine, Medical College of Ohio, Toledo, OH 43614 2598, USA
    Am J Kidney Dis 42:926-35. 2003
    ..This relationship is strongest in the presence of renal insufficiency (RI). The goal of this study is to assess the relationship between RI, mortality, and adverse events in the setting of renovascular disease...
  37. ncbi Factors influencing the progression of renal damage in patients with unilateral renal agenesis and remnant kidney
    Ester González
    Department of Nephrology, Hospital Universitario 12 de Octubre, Madrid, Spain
    Kidney Int 68:263-70. 2005
    ....
  38. ncbi Autologous stem cell transplantation in multiple myeloma: outcome in patients with renal failure
    Lene M Knudsen
    Department of Haematology, HS Rigshospitalet, Copenhagen, Denmark
    Eur J Haematol 75:27-33. 2005
    ..Whereas patients with moderate renal insufficiency seem to benefit from this treatment, patients in need for dialysis at the time of transplant must be carefully evaluated before proceeding to high-dose chemotherapy...
  39. pmc The impact of long-term lithium treatment on renal function in an outpatient population
    Sarah M McCann
    Windsor House, Belfast City Hospital Trust Lisburn Road, Belfast, BT9 7AB, UK
    Ulster Med J 77:102-5. 2008
    ..This study aims to compare younger and older populations of lithium-treated patients and to examine the impact of long-term lithium treatment on renal function...
  40. ncbi The CARI guidelines. Evaluation of renal function
    David Johnson
    Nephrology (Carlton) 10:S133-76. 2005
  41. ncbi [Hypertension and the kidney]
    Katharina Hohenstein
    Klinische Abteilung für Nephrologie und Dialyse, Universitätsklinik für Innere Medizin III, Medizinische Universität Wien, Wien, Austria
    Wien Med Wochenschr 158:359-64. 2008
    ..This review summarizes current evidence for the role of hypertension and proteinuria with regard to renal and cardiovascular outcomes and for the importance of intensive antihypertensive and anti-proteinuric measures...
  42. ncbi Uric acid as a risk factor for progression of non-diabetic chronic kidney disease? The Mild to Moderate Kidney Disease (MMKD) Study
    Gisela Sturm
    Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria
    Exp Gerontol 43:347-52. 2008
    ..In summary, our prospective 7 year follow-up study in patients with non-diabetic primary CKD did not support uric acid as an independent predictor for CKD progression...
  43. ncbi Correlation between plasma milrinone concentration and renal function in patients with cardiac disease
    M Hasei
    Intensive Care Unit, Osaka University Hospital, Osaka, Japan
    Acta Anaesthesiol Scand 52:991-6. 2008
    ..The dose of milrinone should be reduced in patients with renal failure. However, there is little data examining the relationship between plasma concentration of milrinone (pCmil) and renal function in intravenous infusion...
  44. ncbi Renal failure in high altitude: renal functions, renal pathology and bone mineralization in rats with ablation nephropathy at 1200 m altitude
    Alper Soylu
    Department of Pediatrics, Medical Faculty, Dokuz Eylul University, Mithatpaşa Cad No 665 4, 35280, Kucukyali, Izmir, Turkey
    Pathol Res Pract 203:795-800. 2007
    ..006). In conclusion, exposure to 1200 m altitude, compared to the sea level, preserved the creatinine clearance better in 5/6 nephrectomized rats. No change was observed in proteinuria, renal histopathology, and bone mineralization...
  45. ncbi Administration of enoxaparin by continuous infusion in a naturalistic setting: analysis of renal function and safety
    S L Kane-Gill
    Cleveland Clinic Foundation, USA
    J Clin Pharm Ther 30:207-13. 2005
    ..To describe the clinical use and safety of continuous infusion (CI) enoxaparin in a naturalistic setting and to evaluate the influence of renal function on enoxaparin elimination...
  46. ncbi Patients receiving maintenance hemodialysis with low vs high levels of nutritional risk have decreased morbidity
    Jerrilynn D Burrowes
    Department of Nutrition, C W Post Campus of Long Island University, Brooksville, NY 11548, USA
    J Am Diet Assoc 105:563-72. 2005
    ..To compare the demographic and clinical characteristics and outcomes (morbidity) of 442 patients receiving maintenance hemodialysis who are at different levels of nutritional risk...
  47. ncbi [Safe drug prescribing for patients with renal failure]
    Akio Tanaka
    Department of Pharmacy, Chubu Rosai Hospital
    Nihon Rinsho 65:58-66. 2007
  48. ncbi Non-dialysis-dependent renal dysfunction and cardiac surgery-an assessment of perioperative risk factors
    Gopal C Kowdley
    Department of Surgery, University of Chicago Hospitals, Chicago, Illinois, USA
    Curr Surg 62:64-70. 2005
    ..We set forth to ascertain preoperative risk factors important for predicting 2 endpoints: (1) dialysis at discharge and (2) hospital death...
  49. ncbi Restless Legs Syndrome in patients after renal transplantation
    Miklos Zsolt Molnar
    Institute of Behavioral Sciences, Semmelweis University, Budapest, Hungary
    Am J Kidney Dis 45:388-96. 2005
    ..They also analyze the impact of declining renal function on this condition in the Tx population. Finally, the prevalence of RLS was compared between waitlisted dialysis patients (WL), and the Tx group...
  50. ncbi Clinical significance of renal function in hypertensive patients at high risk: results from the INSIGHT trial
    Peter W de Leeuw
    Department of Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Arch Intern Med 164:2459-64. 2004
    ..To assess this role of renal function in more detail, we studied the evolution of renal function and the relationship of renal function with mortality and morbidity in the Intervention as a Goal in Hypertension Treatment (INSIGHT) study...
  51. ncbi Antiretroviral drugs and the kidney: dosage adjustment and renal tolerance
    Hassane Izzedine
    Department of Nephrology, Pitie Salpetriere Hospital, Paris, France
    Curr Pharm Des 10:4071-9. 2004
    ..6 to 1%). Therefore, administration of antiretroviral drugs in human immunodeficiency virus (HIV) patients with nephropathy is not uncommon...
  52. ncbi [Drug dosage in renal failure -- traps and aids]
    Christian Aymanns
    Nephrologie, Medizinische Fakultat, Universitat Ulm, Robert Koch Strasse 8, 89070 Ulm, Germany
    Med Klin (Munich) 99:613-24; quiz 625. 2004
  53. ncbi [No detectable nephrotoxic side effect using a dimer, non-ionic contrast media in cerebral perfusion computed tomography in case of suspected brain ischemia]
    M Petrik
    Institut für Diagnostische Radiologie und Neuroradiologie, Greifswald
    Rofo 177:1242-9. 2005
    ..We were interested to find the best parameters for this examination...
  54. ncbi Incidence and management of penetrating renal trauma in patients with multiorgan injury: extended experience at an inner city trauma center
    Bryan T Kansas
    Department of Urology, Temple University School of Medicine, Philadelphia, Pennsylvania 19111, USA
    J Urol 172:1355-60. 2004
    ..Here we review the incidence of associated injuries in patients with penetrating renal trauma and our extended experience treating these patients at a busy inner city trauma center...
  55. ncbi Renovascular injury: an argument for renal preservation
    Katherine A Barsness
    Division of Pediatric Surgery, Department of Surgery, The Children s Hospital, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Trauma 57:310-5. 2004
    ..Renovascular injury is uncommon among children. This study hypothesized that preservation of the severely injured kidney can be achieved safely without renal insufficiency, postinjury hypertension, or the need for hemodialysis...
  56. ncbi [Effect of inorganic nitrates on the morphofunctional condition of the kidney in the rat]
    Abdelwahab Zaki
    Laboratoire de Physiologie Animale, Faculte des Sciences et Techniques, Beni Mellal, Maroc
    Therapie 60:75-9. 2005
    ..The aim of our experimental study was to determine the effect of exogenic nitrates on certain biological parameters in relation to renal insufficiency...
  57. ncbi Determinants of aciclovir-induced nephrotoxicity in children
    Ruth Schreiber
    Division of Clinical Pharmacology Toxicology, Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
    Paediatr Drugs 10:135-9. 2008
    ..Aciclovir is the drug of choice for severe systemic herpes virus infections. Nephrotoxicity is one of the clinically significant adverse effects of this drug, but studies examining nephrotoxicity in children are scarce...
  58. ncbi Creatinine clearance and risk of early mortality in patients undergoing coronary artery bypass grafting
    Martin J Holzmann
    Department of Thoracic Surgery, Karolinska University Hospital, Stockholm, Sweden
    J Thorac Cardiovasc Surg 130:746-52. 2005
    ....
  59. ncbi Preservation of renal function with surgical revascularization in patients with atherosclerotic renovascular disease
    Luke K Marone
    Massachessetts General Hospital, Boston, Massachusetts 02111, USA
    J Vasc Surg 39:322-9. 2004
    ..To clarify decision making in such patients we reviewed a contemporary experience of surgical renal artery revascularization (RAR) performed primarily for preservation of renal function...
  60. ncbi Assessment of tumor-associated trypsin inhibitor (TATI) as a marker of renal function
    Gianfranco Tramonti
    Department of Internal Medicine, Nephrology Unit, University of Pisa, Pisa, Italy
    J Nephrol 16:663-72. 2003
    ..200 d), as a glomerular filtration rate (GFR) marker. The results were compared with those of beta2-microglobulin and of creatinine (Cr)...
  61. ncbi The role of ultrasonography in the assessment of renal function in the elderly
    Nele Van den Noortgate
    Department of Internal Medicine, Division of Geriatric Medicine, Ghent University Hospital, Ghent, Belgium
    J Nephrol 16:658-62. 2003
    ..This study evaluated a possible correlation between renal function and kidney size measured by ultrasonography (US), and whether the latter helps estimate GFR in the elderly...
  62. ncbi Effect of off-pump and on-pump coronary artery bypass grafting on renal function
    Jale Bengi Celik
    Department of Anesthesiology, Meram Medical School of Selcuk University, Konya, Turkey
    Ren Fail 27:183-8. 2005
    ..This study compared off-pump technique with on-pump technique on renal function in patients who underwent CABG...
  63. ncbi [Postoperative renal failure and its risk factors after open heart surgery]
    Erzsébet Feiler
    Zala Megyei Kórház, Szívsebészeti Osztály
    Orv Hetil 144:799-802. 2003
    ..In this retrospective study the authors have investigated the occurrence and the possible risk factors of renal failure following heart surgery on CPB...
  64. ncbi [Nephrogenic systemic fibrosis]
    W Samtleben
    Schwerpunkt Nephrologie, Medizinische Klinik und Poliklinik I, Klinikum Grosshadern der Ludwig Maximilians Universität München, Marchioninistrasse 15, 81377 Munchen, Deutschland
    Radiologe 47:778-84. 2007
    ....
  65. ncbi Serial ten-year follow-up of HLA and MICA antibody production prior to kidney graft failure
    Kazuo Mizutani
    Terasaki Foundation Laboratory, Los Angeles, California, USA
    Am J Transplant 5:2265-72. 2005
    ..These antibodies found in the peripheral circulation, were not necessarily donor-specific, but their association with failure is consistent with a causality hypothesis...
  66. ncbi C1-inhibitor in patients with severe sepsis and septic shock: beneficial effect on renal dysfunction
    Christoph Caliezi
    Central Laboratory of Hematology, University Hospital, Inselspital, Bern, Switzerland
    Crit Care Med 30:1722-8. 2002
    ..To investigate the efficacy and the safety of the parenteral administration of C1-inhibitor to patients with severe sepsis or septic shock...
  67. ncbi Pre-operative renal function predicts development of chronic renal insufficiency after orthotopic heart transplantation
    Mark R Vossler
    Oregon Cardiac Transplant Program, Division of Cardiology, Oregon Health Sciences University, Portland 97201, USA
    J Heart Lung Transplant 21:874-81. 2002
    ..Risk factors for the development of chronic renal insufficiency after solid-organ transplantation remain unclear...
  68. ncbi Hyperkalemia, renal failure, and converting-enzyme inhibition: an overrated connection
    N H Garcia
    IPEM Gambro Healthcare and National University of Cordoba, Cordoba, Argentina
    Hypertension 38:639-44. 2001
    ..We conclude that in hemodynamically stable rats with reduced renal mass and renal dysfunction, the administration of an ACE inhibitor does not cause severe hyperkalemia...
  69. ncbi [The importance to forewarn or to recommend the indications for renal dialysis]
    F Navazio
    Department of Integrative Biology, 5101 VLSB, University of California at Berkeley, CA 94720 3140, USA
    Clin Ter 153:187-8. 2002
  70. ncbi Incidence of radiocontrast nephropathy in patients undergoing acute stroke computed tomography angiography
    Andrea L Krol
    Stroke 38:2364-6. 2007
    ..We investigated the incidence of contrast-induced renal impairment in these populations...
  71. ncbi Aortic clamping during elective operations for infrarenal disease: The influence of clamping time on renal function
    Eric Wahlberg
    Department of Surgery, Division of Vascular Surgery, University of California, San Francisco, USA
    J Vasc Surg 36:13-8. 2002
    ..The aim of the study was to estimate this risk and possibly identify a "safe" duration of renal ischemia...
  72. ncbi Uraemic symptoms, nutritional status and renal function in pre-dialysis end-stage renal failure patients
    F Caravaca
    , Hospital Universitario Infanta Cristina, Badajoz, Spain
    Nephrol Dial Transplant 16:776-82. 2001
    ..In contrast, Kt/V urea may be a less sensitive and specific method for assessing the severity of uraemia in ESRD patients...
  73. ncbi Calculation of the estimated creatinine clearance in avoiding drug dosing errors in the older patient
    K T Hu
    Department of Medicine, University of California Davis, Sacramento, USA
    Am J Med Sci 322:133-6. 2001
    ..Estimation of glomerular filtration rate should be performed routinely on all admitted patients older than 80 and in any patient with low lean body mass...
  74. ncbi Predictors of outcome in Henoch-Schönlein nephritis in children and adults
    Rosanna Coppo
    Nephrology, Dialysis and Transplantation Unit, Regina Margherita Hospital, Turin, Italy
    Am J Kidney Dis 47:993-1003. 2006
    ..Factors predictive of renal outcome were investigated in 219 cases of biopsy-proven Henoch-Schönlein purpura nephritis (HSPN); 83 children and 136 adults enrolled in a national study were followed up for up to 27 years (median, 4.5 years)...
  75. ncbi Renoprotective effect of chronic adrenomedullin infusion in Dahl salt-sensitive rats
    Toshio Nishikimi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Hypertension 39:1077-82. 2002
    ....
  76. ncbi [Risky medication and contrast media-induced nephropathy in patients with diabetes and hypertension]
    D Krusová
    II interní klinika Lékarské fakulty MU a FN u sv Anny, Brno
    Vnitr Lek 52:1014-20. 2006
    ..g. elimination of risky medication and in indicated cases, taking preventive measures...
  77. ncbi Plasma cystatin C as a marker of renal function in patients with liver cirrhosis
    E Randers
    Department of Internal Medicine, Viborg Kjellerup County Hospital, Viborg, Denmark
    Scand J Clin Lab Invest 62:129-34. 2002
    ..03). The results demonstrate that the diagnostic accuracy of plasma cystatin C was better than plasma creatinine in identifying liver cirrhotic patients with reduced glomerular filtration rate...
  78. ncbi A study on the outcome of percutaneous transluminal renal angioplasty in patients with renal failure
    Louis Roussos
    Department of Nephrology and Transplantation, Malmo University Hospital, Malmo, Sweden
    Nephron Clin Pract 104:c132-42. 2006
    ..The aim of this study was to evaluate the outcome of angioplasty and to identify risk factors associated with less successful outcomes in patients with atheromatous renal artery stenosis and renal failure of varying degrees...
  79. ncbi Tamm-Horsfall protein excretion to predict the onset of renal insufficiency
    Maria C Romero
    Departmento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428, Ciudad Autonoma de Buenos Aires, Argentina
    Clin Biochem 35:65-8. 2002
    ..Immunosuppressive therapy after liver transplantation may be a risk for kidney dysfunction. This work was designed to determine whether Tamm-Horsfall Protein (THP) could be considered as a marker for nephrotoxicity...
  80. ncbi Long-term renal function preservation after renal artery stenting in patients with progressive ischemic nephropathy
    Krishna J Rocha-Singh
    Prairie Heart Institute at St John s Hospital and Prairie Education and Research Cooperative, Department of Cardiology, Southern Illinois University School of Medicine, Springfield, Illinois 62794, USA
    Catheter Cardiovasc Interv 57:135-41. 2002
    ..Renal stent revascularization should be considered a valid therapeutic option for the long-term treatment of ischemic nephropathy...
  81. ncbi Relationship between hematocrit and renal function in men and women
    C Y Hsu
    Division of Nephrology, University of California, San Francisco, San Francisco, California 94143-0532, USA
    Kidney Int 59:725-31. 2001
    ..CONCLUSIONS: A decrease in hematocrit is apparent even among patients with mild to moderate renal insufficiency. At any given level of renal function below estimated C(Cr) 60 mL/min, men have a larger decrease in hematocrit than women...
  82. ncbi Nephropathy requiring dialysis after percutaneous coronary intervention and the critical role of an adjusted contrast dose
    Rosario V Freeman
    Division of Cardiology, University of Washington, Seattle, Washington, USA
    Am J Cardiol 90:1068-73. 2002
    ..A risk prediction tool for NRD with guidelines for prevention is presented...
  83. ncbi Pharmacokinetics of pregabalin in subjects with various degrees of renal function
    Edward J Randinitis
    Clinical Sciences Department, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    J Clin Pharmacol 43:277-83. 2003
    ..Supplemental pregabalin doses may be required for patients on chronic hemodialysis treatment after each hemodialysis treatment to maintain steady-state plasma pregabalin concentrations within desired ranges...
  84. ncbi Effects of a diet rich in advanced glycation end products in the rat remnant kidney model
    Katarina Sebekova
    Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic
    Am J Kidney Dis 41:S48-51. 2003
    ..Although bioactivity of orally absorbed MRPs has been shown in both experimental and human studies, its relevance in renal insufficiency still is unclear...
  85. ncbi Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients
    B Bammens
    Department of Medicine, Division of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium
    Kidney Int 69:1081-7. 2006
    ..These findings may encourage nephrologists to widen their field of interest beyond the scope of small water-soluble uremic solutes and middle molecules...
  86. ncbi Acetylcysteine for prevention of acute deterioration of renal function following elective coronary angiography and intervention: a randomized controlled trial
    Jay Kay
    Cardiac Medical Unit, Grantham Hospital, 125 Wong Chuk Hang Rd, Aberdeen, Hong Kong
    JAMA 289:553-8. 2003
    ..The antioxidant acetylcysteine prevents acute contrast nephrotoxicity in patients with impaired renal function who undergo computed tomography scanning. However, its role in coronary angiography is unclear...
  87. ncbi Estimation of benchmark dose as the threshold levels of urinary cadmium, based on excretion of total protein, beta2-microglobulin, and N-acetyl-beta-D-glucosaminidase in cadmium nonpolluted regions in Japan
    Etsuko Kobayashi
    Department of Occupational and Environmental Medicine A2, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuohku, Chiba, 260 8670 Japan
    Environ Res 101:401-6. 2006
    ....
  88. ncbi Peri-operative renal function and outcome after orthotopic heart transplantation
    Jonah Odim
    Department of Surgery, Medicine and Pathology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1741, USA
    J Heart Lung Transplant 25:162-6. 2006
    ..Renal insufficiency is an established risk factor in patients undergoing cardiovascular surgery. We sought to evaluate the relationship between renal function and outcomes after orthotopic heart transplantation (OHT)...
  89. ncbi Unexpectedly high prevalence of posttransplant anemia in pediatric and young adult renal transplant recipients
    Peter D Yorgin
    Section of Pediatric Nephrology, Department of Pediatrics, Lucile Salter Packard Children s Hospital, Stanford University, Stanford, CA 94304, USA
    Am J Kidney Dis 40:1306-18. 2002
    ..Although posttransplant anemia (PTA) is recognized as a common problem in adult renal transplant recipients, few pediatric studies have been published...
  90. ncbi Clinical utility of cardiac troponin I in the diagnosis of acute coronary syndrome in patients with renal failure
    Saravanan Balamuthusamy
    Department of Medicine and Cardiology, Chicago Medical School at Rosalind Franklin University, Chicago, IL, USA
    Am J Ther 14:356-60. 2007
    ..cTnI has a sensitivity of 60% and specificity of 71% in acute coronary syndrome patients with renal insufficiency. In patients on hemodialysis, troponin I has a sensitivity of 73% and specificity of 83% for detection of obstructive CAD...
  91. ncbi Stable patients with atherosclerotic renal artery stenosis should be treated first with medical management
    Stephen C Textor
    Division of Hypertension, Mayo Clinic, Rochester, MN, USA
    Am J Kidney Dis 42:858-63. 2003
  92. ncbi Serum cystatin C as a marker of glomerular filtration rate
    Magdalena Madero
    Division of Nephrology, Tufts New England Medical Center, Boston, Massachusetts, USA
    Curr Opin Nephrol Hypertens 15:610-6. 2006
    ..This review summarizes the currently available glomerular filtration rate estimating equations based on cystatin C and the literature comparing cystatin C and creatinine as filtration markers...
  93. ncbi [Hepatitis C viral in patients with terminal chronic kidney failure. I. Prevalence]
    L Gonzalez-Michaca
    Departamento de Nefrologia y Metabolismo Mineral, Instituto Nacional de la Nutricion Salvador Zubiran
    Rev Invest Clin 52:246-54. 2000
    ..Thus, the major goals of the present study were to determine the prevalence of hepatitis C in our patients on dialysis, and the risk factors associated with it...
  94. pmc A decade of experience with renal transplantation in African-Americans
    Clarence E Foster
    Division of Transplantation, Department of Surgery, School of Medicine, University of Maryland, Baltimore, Maryland 210201, USA
    Ann Surg 236:794-804; discussion 804-805. 2002
    ..Once kidney failure has developed, African-Americans are disadvantaged for the following reasons: this patient cohort has longer ..
  95. ncbi The dental health status of dialysis patients
    Judith T Klassen
    Division of Nephrology, St Paul s Hospital, 1702 20th Street West, Saskatoon, SK, Canada
    J Can Dent Assoc 68:34-8. 2002
    The number of patients with kidney failure who require dialysis is growing by 10% to 15% annually, and the likelihood that dentists will treat such patients is also increasing...
  96. ncbi [Studies on the kidney and the renal circulation, by Josep Trueta i Raspall (1897-1977)]
    Fariña L A Pérez
    Servicio de Urologia, Hospital POVISA, Vigo, Pontevedra
    Actas Urol Esp 32:276-80. 2008
    ..One of the most outstanding fruits of this investigation is the book "Studies on renal circulation", first published in English in 1947 (Oxford), then in Spanish in 1949 (Barcelona)...
  97. ncbi Electrochemistry in diabetes management
    Adam Heller
    Department of Chemical Engineering, University of Texas, Austin, Texas 78712, USA
    Acc Chem Res 43:963-73. 2010
    ..Periods of hyperglycemia (high glucose) cause circulatory disease, stroke, amputations, blindness, kidney failure and nerve degeneration...
  98. ncbi Caspofungin versus amphotericin B for candidemia: a pharmacoeconomic analysis
    John R Wingard
    University of Florida College of Medicine, Gainesville, 32610, USA
    Clin Ther 27:960-9. 2005
    ..7% and 62.8% of patients, respectively) and exhibited a generally better safety profile, particularly with respect to impaired renal function (IRF) (P = 0.02)...
  99. ncbi Italian multicenter study on complications of laparoscopic myomectomy
    Ornella Sizzi
    Villa Valeria Hospital, Rome, Italy
    J Minim Invasive Gynecol 14:453-62. 2007
    ..To study intraoperative and postoperative complications of laparoscopic myomectomy and patients' characteristics influencing this risk...
  100. pmc Human cytomegalovirus: detection of congenital and perinatal infection in Argentina
    Angélica Lidia Distéfano
    Department of Virology, Laboratorio de Virosis Congénitas Perinatales y Transmisión Sexual, Instituto Nacional de Microbiología INEI ANLIS Carlos G, Malbran, Ministerio de Salud de la Nación, Av, CP 1281, Buenos Aires, Argentina
    BMC Pediatr 4:11. 2004
    ..Results were compared with IgM detection...
  101. ncbi [Regeneration capacity of skeletal muscle]
    A Wernig
    Physiologisches Institut, Universitat Bonn
    Ther Umsch 60:383-9. 2003
    ..may decide to change his/her (locomotor) behaviour by severe onset of jogging; it may happen that they suffer kidney failure on Monday due to muscle microdamage and the transfer of myoproteins into the serum over weekend...

Research Grants79

  1. Cardiotrophin-Like Cytokine 1, a Candidate Molecule for the FSGS Factor
    Virginia J Savin; Fiscal Year: 2010
    ..leaks into the urine and, if damage and protein leak continue, further scarring of the entire kidney leads to kidney failure. FSGS a leading cause of kidney failure in children and causes kidney failure in many adults, as well...
  2. Exercise training and blood pressure in hypertension: integrated mechanisms
    Noreen F Rossi; Fiscal Year: 2012
    ..It is the primary risk-factor for development of stroke and heart failure and the second most common cause of kidney failure. Prompt diagnosis and effective treatment are suboptimal with only 60% of Veterans meeting the 7th Joint ..
  3. A Hybrid Katp Channel Opener to Prevent Radiocontrast-Induced Nephropathy
    Kanneganti Murthy; Fiscal Year: 2012
    ..We now propose to test this agent in a clinically-relevant small animal model of radiocontrast-induced kidney failure.
  4. A Thioredoxin Mimetic for Radiocontrast Nephropathy
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..We now propose to test this agent in a clinically-relevant small animal model of radiocontrast-induced kidney failure.
  5. Dietary Lipids and Silica-Accelerated Autoimmunity
    James J Pestka; Fiscal Year: 2013
    ..a prototypical autoimmune disease affecting 300,000 Americans and often associated with glomerulonephritis and kidney failure, is increased by occupational exposure (e.g...
  6. Aldosterone Action In The Brain, Hypertension and Inflammation
    ELISE PEERY GOMEZ-SANCHEZ; Fiscal Year: 2012
    ..extra salt, its plasma and total body aldo production levels are normal, and it is predisposed to heart and kidney failure. In Specific Aim 1 we propose to study the expression of AS in relation to the MR and the regulation of aldo ..
  7. The mechanisms by which alcohol and HIV render the lung susceptible to injury
    DAVID MARSHALL GUIDOT; Fiscal Year: 2013
    ..infected individuals must battle a chronic disease that increases their risk of lung disease, heart disease, kidney failure and malignancies...
  8. Identifying all Meckel-like ciliopathy genes by established total exome capture a
    Friedhelm Hildebrandt; Fiscal Year: 2010
    ..complex (CCC) defined the disease group of "retinal-renal ciliopathies", the most frequent genetic cause of kidney failure in the first 30 years of life...
  9. A multicenter clinical trial of allopurinol to prevent GFR loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2012
    ..GFR decline in T1D subjects, we will have a simple, safe, and inexpensive intervention to prevent or delay kidney failure in T1D that can be applied at the earliest clinically detectable stages of renal injury...
  10. Improving Hmong Health through Community Based Participatory Research
    DIAN LORENE BAKER; Fiscal Year: 2013
    ..to manage diabetes, leads to increased burden of disease such as the disproportionate rates of heart disease, kidney failure, loss of vision, and peripheral neuropathy found among the Hmong...
  11. Novel drug VS-105 for treatment of diabetic nephropathy
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2012
    ..onset) diabetes and up to 40% of those with Type 2 (adult onset) diabetes eventually will suffer from kidney failure. In 2010 39.6% of people with diagnosed and 41.7% with undiagnosed diabetes had CKD...
  12. Metabolic Crosstalk Between Immune Cells and the Liver in Obesity
    BENJAMIN MANTELL; Fiscal Year: 2012
    ..levels of morbidity and mortality;they are leading causes of non-alcoholic fatty liver disease, blindness, kidney failure and non-traumatic amputations, and these patients are also at increased risk for cardiovascular disease...
  13. Novel genetics, pathobiology &therapy of nephronophthisis-related ciliopathies
    Friedhelm Hildebrandt; Fiscal Year: 2013
    ..NPHP) is a monogenic recessive cystic kidney disease that represents the most frequent genetic cause of kidney failure in the first 30 years of life...
  14. Novel Phosphate Binder: Effects on Hyperphosphatemia, Vascular Calcification & Bo
    DEANNA J contact NELSON; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Kidney failure, already a major public health problem in the US, is becoming more common...
  15. Transcriptional regulation of proteinuria
    SUMANT SINGH CHUGH; Fiscal Year: 2011
    b>Kidney failure is a major cause of morbidity and mortality in the United States and worldwide. Transcriptional regulation of podocyte diseases is not as yet well understood...
  16. Design of a Multicenter Clinical Trial of Allopurinol to Prevent GFR Loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2011
    ..GFR decline in T1D subjects, we will have a simple, safe, and inexpensive intervention to prevent or delay kidney failure in T1D that can be applied at the earliest clinically detectable stages of renal injury...
  17. Muscle Wasting in Uremia
    Ralph Rabkin; Fiscal Year: 2012
    ..There is very little information on the impact of disuse on the muscle wasting in the patient with advanced kidney failure, even though hospitalization is frequent...
  18. Mechanisms of tubular atrophy in renal disease
    Jeffrey R Schelling; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Over 500,000 people in the U.S. have kidney failure that requires dialysis or transplantation to stay alive...
  19. MicroRNA-Based Therapeutics for Rare Cystic Kidney Diseases
    Peter Igarashi; Fiscal Year: 2010
    ..These rare genetic disorders are characterized by the formation of cysts in the kidneys and progressive kidney failure. Extrarenal manifestations include congenital hepatic fibrosis (ARPKD), diabetes (RCAD), and blindness (NPHP)...
  20. Quality Dialysis Outcomes and Practice Patterns Study (DOPPS): high-quality care
    Francesca Tentori; Fiscal Year: 2013
    ..is to become an independently funded investigator and to make important contributions in outcomes research in kidney failure by identifying modifiable clinical practices that may improve the quality of care in HD...
  21. Conservative Versus Dialytic Management in Stage V Chronic Kidney Disease
    GLENN MATTHEW CHERTOW; Fiscal Year: 2010
    ..The degree to which poor health status results from kidney failure versus other associated diseases versus imperfections and complications of dialysis is unknown...
  22. Role of Meprin A in Acute Kidney Injury
    GUR PRASAD KAUSHAL; Fiscal Year: 2013
    ..The expenses related with kidney failure are estimated at $10 billion per year...
  23. Investigation of Nephrotic Syndrome
    LIONEL CLAUDIUS CLEMENT; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Nephrotic syndrome is a major cause of kidney failure, and patients with this condition develop large amounts of proteinuria and elevated levels of plasma lipids (triglycerides and cholesterol)...
  24. Mechanisms of cLDL-Induced Endothelial Injury
    Sudhir V Shah; Fiscal Year: 2013
    ..In addition, we have demonstrated that elevated plasma cLDL concentration from either chronic kidney failure or chronic urea consumption results in the development of aortic atherosclerosis in mice...
  25. Multi-center Controlled Clinical Trials in Alport Syndrome-A Feasibility Study
    Clifford E Kashtan; Fiscal Year: 2013
    ..Males with Alport syndrome inevitably develop end-stage kidney failure, with a 50% likelihood of dialysis or kidney transplantation by age 25 years...
  26. PERL: A multicenter clinical trial of allopurinol to prevent GFR loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2013
    ..slow down GFR decline in T1D subjects, we will provide a safe and inexpensive intervention to prevent or delay kidney failure in T1D that can be applied at the earliest clinically detectable stages of renal injury...
  27. Genetic contributors to diabetes and dyslipidemia in African Americans
    Michele M Sale; Fiscal Year: 2010
    ..million African Americans, and leads to a devastating range of complications, including heart attack, stroke, kidney failure, blindness, amputation, and nerve pain...
  28. NITRIC OXIDE AND OXYGENATION IN DIABETIC KIDNEYS
    NILS AXEL FREDRIK PALM; Fiscal Year: 2010
    ..Furthermore, diabetes is the leading cause of kidney failure, accounting for 44% of all new cases in 2002...
  29. MRI Imaging Biomarkers of ARPKD Kidney and Liver Disease
    Christopher A Flask; Fiscal Year: 2013
    ..b>Kidney failure develops in 40-50% of affected children by age 10...
  30. Residual Kidney Function in ESRD: Measurements, Serum Markers and Outcomes
    Tariq Shafi; Fiscal Year: 2013
    ..Kidney function, even after start of dialysis, plays an important role in clearing kidney failure toxins and improves survival...
  31. MURINE TYPHUS: VECTOR BIOLOGY AND TRANSMISSION
    Abdu F Azad; Fiscal Year: 2013
    ..e., seizures, respiratory and kidney failure, and persistent frontal and temporal lobe dysfunction) or death...
  32. Meprin A Metalloproteinase in Acute Kidney Injury
    GUR PRASAD KAUSHAL; Fiscal Year: 2013
    ..patients and 30 % of ICU admissions with a high mortality rate and the expenses related for patients with kidney failure are estimated at $10 billion per year...
  33. Biomolecular Markers of Renal Allograft Status
    Thangamani Muthukumar; Fiscal Year: 2013
    ..Research Project: Renal transplantation is the preferred treatment for irreversible kidney failure. Short term outcomes have improved over the years, nevertheless, almost 50% fail by 10 years...
  34. The exocyst in ciliogenesis and cystogenesis
    Joshua H Lipschutz; Fiscal Year: 2013
    ..people, or 500,000 Americans, is the most common potentially lethal genetic disease and 4th leading cause of kidney failure. Given 25 million veterans and another 45 million family members, there are at least 100,000 veterans or ..
  35. Measurement of Renal Viscoelastic Properties with Ultrasound
    MATTHEW WILLIAM URBAN; Fiscal Year: 2013
    ..5% in American adults aged 20 and over, which is more than 20 million people. CKD can progress to kidney failure or end-stage renal disease (ESRD)...
  36. Angiotensin II, IGF-1 and Skeletal Muscle Atrophy
    Patrice Delafontaine; Fiscal Year: 2013
    ..provided by applicant): Cachexia is a major complication of chronic diseases such as heart failure, kidney failure and cancer. In these conditions the renin-angiotensin system (RAS) is often activated...
  37. OUTER MEMBRANE PROTEINS OF PATHOGENIC LEPTOSPIRA SPECIES
    David A Haake; Fiscal Year: 2013
    ..Leptospiral infection in humans frequently results in fulminate liver dysfunction, kidney failure, and severe pulmonary hemorrhage syndrome with a mortality rate of >10%...
  38. Molecular Mechanisms of Albumin Trafficking in Podocytes
    Judith T Blaine; Fiscal Year: 2013
    ..differentiated cells with low regenerative capacity and podocyte loss is strongly correlated with progressive kidney failure. In addition, this proposal will lay the foundation for an R01 submission...
  39. Immune Dysregulation in Uremia
    Neal B Blatt; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic kidney failure, also known as end-stage renal disease (ESRD), results in the build-up of waste toxins that affect organs and tissues throughout the body, and causes significant mortality...
  40. Ergocalciferol in ESRD Efficacy Safety and Biology
    Ravi Thadhani; Fiscal Year: 2010
    ..RELEVANCE: Infection is the second-leading cause of death in individuals requiring dialysis treatment for kidney failure. New research suggests the high risk of infection may be due in part to low levels of vitamin D, which are ..
  41. TERMINAL DIFFERENTIATION OF THE RENAL EPITHELIUM
    Samir S El-Dahr; Fiscal Year: 2012
    ..e., congenital malformations) account for up to 40% of cases of chronic kidney failure in infants and children requiring dialysis and transplantation...
  42. Histone Deacetylases and Kidney Development
    Samir S El Dahr; Fiscal Year: 2010
    ..HEALTH RELEVANCE: Congenital malformations of the kidney and urinary tract account for up to 40% of chronic kidney failure in children less than 4 years of age...
  43. Novel therapeutics for alcoholic hepatitis - Cleveland Translational Component
    Laura E Nagy; Fiscal Year: 2013
    ..analysis of sensitive biomarkers of kidney function which would allow for early diagnosis and treatment of kidney failure in patients with AH...
  44. Genome-wide fine-mapping of metabolic traits in heterogeneous stock rats
    LEAH CATHERINE SOLBERG WOODS; Fiscal Year: 2013
    ..T2D is a leading cause of kidney failure, blindness and limb amputation and a major risk factor for heart disease and stroke (18)...
  45. Endothelial Injury in Endotoxin-Induced Acute Renal Failure
    Patrick N Cunningham; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Acute kidney failure (ARF) is a common complication in hospitalized patients that leads to great morbidity and mortality, and ..
  46. CFTR inhibitors for therapy of polycystic kidney disease
    Alan S Verkman; Fiscal Year: 2010
    ..HEALTH RELEVANCE: Polycystic kidney disease is one of the most common genetic diseases and a major cause of kidney failure leading to dialysis or kidney transplantation...
  47. Intraspecies Transmission and Infectivity of Insectivore-Borne Hantaviruses
    Richard Yanagihara; Fiscal Year: 2011
    ..One is a type of hemorrhagic fever with associated kidney failure occurring in Europe and Asia and the other is a rapidly progressive, frequently fatal respiratory disease ..
  48. Disparities in Progression to Renal Replacement Therapy
    Stephen F Derose; Fiscal Year: 2011
    ..knowledge about how to eliminate racial/ethnic disparities in end-stage renal disease (ESRD, which includes dialysis and transplantation), particularly among African Americans and Hispanics, who are at the highest risk of kidney failure.
  49. Molecular regulation of renal 125(OH)2D production by Fibroblast Growth Factor23
    Farzana Perwad; Fiscal Year: 2010
    ..Understanding how various factors control vitamin D production will provide new therapeutic strategies to treat bone disease in children with rickets, and in patients suffering from kidney failure.
  50. Three-dimensional Human Kidney Tissue System for Studying Renal Diseases
    Jeannine Coburn; Fiscal Year: 2013
    ..challenges the function of the kidney and can eventually result in renal fibrosis, chronic kidney disease and kidney failure. Current laboratory tools to study the kidney include monolayer cell cultures and animal models...
  51. TGF-beta superfamily in neonatal obstructive nephropathy and recovery
    Robert L Chevalier; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Half of all children with kidney failure are born with birth defects of the urinary tract, and the most common of these are due to obstruction to urine ..
  52. Aldosterone, nitric oxide, myocardial fibrosis, and capillary loss in ESRD
    David M Charytan; Fiscal Year: 2013
    ..Traditional CV risk factors are less important in the setting of advanced kidney failure, and the disappointing results with standard therapies appear to be attributable to important differences in ..
  53. Cardiac and Renal Effects of N-Acetylcysteine
    Markus Meyer; Fiscal Year: 2011
    ..Unfortunately, these contrast agents are toxic to the kidneys and some patients will develop kidney failure. We are investigating if the antioxidant N-Acetylcysteine added to a contrast agent can reduce kidney toxicity ..
  54. Lipoproteins and PEDF in the Vascular Complications of Diabetes
    Timothy J Lyons; Fiscal Year: 2010
    ..Project Narrative Diabetes and its complications (premature heart attacks and strokes, amputations, kidney failure, blindness, and nerve damage) are epidemic in our nation and the world, and effective strategies to predict, ..
  55. Mechanistic insights into cellular metal detoxification
    Jaekwon Lee; Fiscal Year: 2013
    ..For example, cadmium is a highly toxic environmental contaminant and implicated in disorders, including kidney failure, cancer, reproductive defects, and endocrine disruption...
  56. Metabolic Actions of Brain Leptin Receptors Signaling in Type 1 Diabetes
    Roberto Coppari; Fiscal Year: 2012
    ..debilitating, long-lasting and economically challenging conditions as for example heart disease, blindness, kidney failure, neuropathy, and hypertension...
  57. Relative Roles of HSP70 and HSP25 in the Modulation of Renal Injury
    Rajasree Sreedharan; Fiscal Year: 2010
    ..The proposed studies will help understand the molecular processes involved in acute kidney failure and recovery...
  58. Histone Acetyl Transferase HBO1 in kidney epithelial cell cycle
    Maria V Panchenko; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Ischemia and reperfusion is a leading cause of acute kidney failure. Proximal tubular epithelial cells are most sensitive to this stress...
  59. Commercialization of Tissue Lined Stent Graft for Dialysis Access Failure
    DON GUSTAVSON; Fiscal Year: 2013
    ..leading treatment for more than 341,000 patients in the United States with end-stage renal disease (ESRD), or kidney failure, which can be caused by common chronic conditions such as diabetes and hypertension...
  60. Mineral metabolism disturbances and arteriovenous fistula maturation
    Bryan R Kestenbaum; Fiscal Year: 2013
    ..Unfortunately, as many as 50% of AVFs fail to mature within the toxic metabolic environment of kidney failure. Disturbances in mineral metabolism, which are common among ESKD patients, may be novel causes of AVF ..
  61. Mechanisms of Regulation Of NHE-1
    John R Raymond; Fiscal Year: 2012
    ..The work could lead to new therapies for hypertension, congestive heart failure, cardiomyopathies and kidney failure.
  62. APOL1 variants: Understanding the basis of disparities in rates of kidney disease
    Martin R Pollak; Fiscal Year: 2013
    SUMMARY More than 500,000 Americans suffer from end-stage renal disease (ESRD). African Americans develop kidney failure at rates 4-5 fold higher than European Americans...
  63. Hypertension Pharmacogenetics
    Julie Johnson; Fiscal Year: 2006
    ..in the United States, and is a leading cause of stroke, acute myocardial infarction (MI), heart failure and kidney failure. There are numerous effective antihypertensive drug classes, but only about half of patients have a good ..
  64. PREVENTING CONTRAST-INDUCED NEPHROPATHY
    Ali Hassan; Fiscal Year: 2009
    ..agents are toxic to the kidney, and exposure can lead to contrast induced nephropathy (CIN), a form of acute kidney failure, in patients with pre-existing renal insufficiency...
  65. Exercise-Facilitated NeuroRehabilitation in Diabetic Neuropathy
    EVAN STUBBS; Fiscal Year: 2009
    ..SIGNIFICANCE OF PROBLEM: Diabetes mellitus afflicts more than 20 million Americans and is the main cause of kidney failure, new onset blindness, and neuropathy-associated limb amputations in adults...
  66. Glucose monitoring using polarized light
    Gerard L Cote; Fiscal Year: 2010
    ..tighter control, and fewer secondary complications from diabetes mellitus, such as heart disease, blindness, kidney failure, gangrene, and blindness...
  67. Glucocorticoid Receptor Function in Steroid Resistant Childhood Nephrotic Syndrom
    JORGE A INIGUEZ LLUHI; Fiscal Year: 2010
    ..steroid resistant nephrotic syndrome, placing them at significantly increased risk for the development of kidney failure. Despite its clinical importance, the molecular basis of steroid sensitive (SSNS) vs...
  68. Development of a National Incompatible Kidney Transplant Registry
    Robert A Montgomery; Fiscal Year: 2010
    ..Live donor kidney transplantation is the best treatment for kidney failure, doubling life expectancy and significantly improving quality of life...
  69. Pathogenicity of Shiga Toxin-Producing E. coli
    ALISON O BRIEN; Fiscal Year: 2007
    ..the hemolytic uremic syndrome (HUS), a sequela of O 157:H7 infection, is the most frequent basis for acute kidney failure in U.S. children...
  70. S.T.R.A.P Sonos Transportable Renal Application Product
    Martin Roberts; Fiscal Year: 2005
    ..Compliance is low for this intense procedure, and the treatment becomes inadequate with complete kidney failure, requiring a transfer to hemodialysis. Unfortunately, mortality with either technique is over 20% per year...
  71. Gene-engineered dendritic cell therapy for diabetics
    Massimo Trucco; Fiscal Year: 2006
    ..However, these strategies can lead to an array of other problems including kidney failure and a risk of malignancy...
  72. Gene-engineered dendritic cell therapy for diabetics
    Massimo Trucco; Fiscal Year: 2003
    ..However, these strategies can lead to an array of other problems including kidney failure and a risk of malignancy...
  73. The Role of BMP-7 in Chronic Kidney Disease
    Keith Hruska; Fiscal Year: 2005
    ..A second hypothesis to be tested is that replacement of BMP-7 in chronic kidney failure will maintain bone remodeling rates in the absence of secondary hyperparathyroidism...
  74. Prevention of Type I Diabetes Mellitus using a Cell Vac*
    Nick Giannoukakis; Fiscal Year: 2002
    ..and consequently, many patients eventually succumb to debilitating and life-threatening complications such as kidney failure and heart disease...
  75. Cellular Physiology of Podocytes
    Stuart E Dryer; Fiscal Year: 2010
    ..Diabetic nephropathy is the leading cause of kidney failure in the developed world...
  76. Improving Kidney Transplant Outcome with a Novel Complement Inhibitor
    SHELLEY MAVES; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): For the greater than 100,000 Americans who suffer from kidney failure each year, transplantation is their best treatment option...
  77. The Pathogenesis of Sickle Cell Nephropathy
    Antonio Guasch; Fiscal Year: 2010
    ..is a common complication of sickle cell disease that affects both children and adults, and may lead to kidney failure. The mechanisms that cause kidney damage in sickle cell disease are not well understood...
  78. GLYCOSYLATED PROTEINS--DEVELOPING DIABETIC KIDNEY
    Edward Skolnik; Fiscal Year: 1993
    ..While most scientists agree that kidney failure in diabetes results from the abnormal diabetic environment, the mechanisms by which a chronic increase in ..
  79. Regulation of CD32A in neutrophils
    Periasamy Selvaraj; Fiscal Year: 2007
    ..Such a tissue injury also results in glomerulonephritis leading to kidney failure and death in these disease states...