Genomes and Genes
Summary: Inflammation of the kidney. It is a focal or diffuse proliferative or destructive process which may involve the glomerulus, tubule, or interstitial renal tissue. (Dorland, 27th ed)
Publications186 found, 100 shown here
- De novo C1q nephropathy in the renal allograft of a kidney pancreas transplant recipient: BK virus-induced nephropathy?Jorge Isaac
ARUP Laboratories, Department of Anatomical Renal Pathology A513, University of Utah Health Sciences Center, 50 North Medical Drive, Salt Lake City, UT 84132, USA
Nephron 92:431-6. 2002..Interstitial nephritis secondary to BK polyomavirus is a recently recognized complication in kidney transplant recipients...
- Effects of allopurinol treatment on the progression of chronic nephritis in Canine leishmaniosis (Leishmania infantum)K Plevraki
Clinic of Companion Animal Medicine, School of Veterinary Medicine, Aristotle University of Thessaloniki, Greece
J Vet Intern Med 20:228-33. 2006..Mesangioproliferative and tubulointerstitial nephritis were detected even in group A and CA dogs...
- Henoch-Schönlein purpura nephritis in children: risk factors, prevention and treatmentRadovan Bogdanovic
The Institute of Mother and Child Healthcare of Serbia Dr Vukan Cupic, Belgrade, Serbia
Acta Paediatr 98:1882-9. 2009To identify risk factors for a child with Henoch-Schönlein purpura (HSP) either to develop nephritis (HSPN) or to contract progressive course and to obtain the currently available evidence on the efficacy of treatment options in both ..
- Clinical outcome in children with Henoch-Schönlein nephritisSevgi Mir
Faculty of Medicine, Department of Pediatric Nephrology, Ege University, Izmir, Turkey
Pediatr Nephrol 22:64-70. 2007..features of the children with HSP and the prognoses of short- and long-term outcome of patients diagnosed as HSP nephritis (HSN)...
- Human heme oxygenase-1 deficiency presenting with hemolysis, nephritis, and aspleniaNita Radhakrishnan
Department of Pediatrics, Pediatric Hematology Oncology and BMT Unit, Sir Ganga Ram Hospital, New Delhi, India
J Pediatr Hematol Oncol 33:74-8. 2011..report another case of human HO-1 deficiency in a young girl with congenital asplenia, who presented with severe hemolysis, inflammation, nephritis, which was refractory to therapy with corticosteroids, cyclophosphamide, and rituximab.
- 15-Deoxyspergualin and cyclophosphamide, but not mycophenolate mofetil, prolong survival and attenuate renal disease in a murine model of ANCA-associated crescentic nephritisRainer Birck
Fifth Department of Medicine, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, D 68135 Mannheim, Germany
Nephrol Dial Transplant 21:58-63. 2006Here we compare the efficacy of cyclophosphamide (CYC) for treatment of crescentic nephritis (CGN) with the newer immunosuppressants 15-deoxyspergualin (DSG) and mycophenolate mofetil (MMF) in SCG/Kj mice, an inbred mouse strain that ..
- Effects of all-trans retinoic acid on renin-angiotensin system in rats with experimental nephritisC Dechow
Division of Nephrology, University of Heidelberg, D-69115, Germany
Am J Physiol Renal Physiol 281:F909-19. 2001..1 nephritis (Wagner J, Dechow C, Morath C, Lehrke I, Amann K, Floege J, and Ritz E. J Am Soc Nephrol 11: 1479-1489, 2000)...
- Recovery of BK virus large T-antigen-specific cellular immune response correlates with resolution of bk virus nephritisSimon E Prosser
1 Division of Nephrology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Transplantation 85:185-92. 2008..BKV infection progresses to BKV nephritis (BKVN) in approximately 8% of transplants and in half of these cases the graft is lost.
- Effect of early corticosteroid therapy on development of Henoch-Schönlein nephritisUmut S Bayrakci
Department of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey
J Nephrol 20:406-9. 2007..Findings of previous reports addressing the preventive effect of corticosteroid treatment in HSP nephritis have been inconsistent...
- Predictive factors for nephritis, relapse, and significant proteinuria in childhood Henoch-SchÃ¶nlein purpuraJ I Shin
Department of Paediatrics, The Institute of Kidney Disease, Yonsei University, College of Medicine, Seoul, Korea
Scand J Rheumatol 35:56-60. 2006OBJECTIVE: To identify predictive factors for nephritis, relapse, and significant proteinuria in childhood Henoch-SchÃ¶nlein purpura (HSP)...
- Outcome of Henoch-Schönlein purpura nephritis treated with long-term immunosuppressionMohan Shenoy
Department of Paediatric Nephrology, Royal Manchester Children s Hospital, Manchester M27 4HA, UK
Pediatr Nephrol 22:1717-22. 2007This retrospective study investigated the outcome of 27 children (19 male) with Henoch-Schönlein purpura nephritis (HSN) of International Study of Kidney Disease in Children (ISKDC) grade 3b or higher treated with long-term ..
- Ras antagonist farnesylthiosalicylic acid (FTS) reduces glomerular cellular proliferation and macrophage number in rat thy-1 nephritisHelen C Clarke
Renal Medicine, GKT School of Medicine, King's College, London, England
J Am Soc Nephrol 14:848-54. 2003..This article reports the effects of Ras antagonist farnesylthiosalicylic acid (FTS) in rat thy-1 nephritis, a model in which cytokine-driven glomerular cell proliferation and invasion is likely to involve Ras signaling ..
- Henoch-Schönlein purpura nephritis with nephrotic state in children: predictors of poor outcomesHitoshi Wakaki
Department of Pediatrics, Yokohama Municipal Citizen s Hospital, 56 Okazawa cho, Hodogaya ku, Yokohama, 240 0062, Japan
Pediatr Nephrol 26:921-5. 2011b>Nephritis develops in 18-81% of Henoch-Schönlein purpura patients, and the long-term outcomes of this nephritis show great variation. A nephrotic state at disease onset has been proposed as a predictor of poor renal outcomes...
- Henoch-Schönlein nephritis: a nationwide studyO Soylemezoglu
Gazi University, Department of Pediatric Nephrology, Ankara, Turkey
Nephron Clin Pract 112:c199-204. 2009The aim of this retrospective study was to evaluate the presentation, clinical and pathological manifestations and outcome of the Henoch-Schönlein purpura (HSP) nephritis in children.
- High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathyYoko Oyama
Department of Laboratory and Vascular Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Lab Invest 90:853-66. 2010Granulomatous nephritis can be triggered by diverse factors and results in kidney failure. However, despite accumulating data about granulomatous inflammation, pathogenetic mechanisms in nephritis remain unclear...
- Interleukin 8 gene polymorphism is associated with increased risk of nephritis in cutaneous vasculitisMahsa M Amoli
ARC Epidemiology Unit, Manchester University Medical School, Manchester, United Kingdom
J Rheumatol 29:2367-70. 2002....
- Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr miceA M Jevnikar
Robarts Research Institute, University of Western Ontario, London, Canada
J Exp Med 179:1137-43. 1994..Whereas non-MHC linked genes can have a profound effect on the development of nephritis, lymphadenopathy, and anti-DNA antibody production in MRL-lpr mice, the role of MHC molecules has not been ..
- Anti-programmed cell death 1 antibody reduces CD4+PD-1+ T cells and relieves the lupus-like nephritis of NZB/W F1 miceShimpei Kasagi
Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650 0017, Japan
J Immunol 184:2337-47. 2010..In this study, we used NZB/W F1 mice, a model of lupus-like nephritis, to examine the function of PD-1 and its ligands...
- Interleukin-6 promoter polymorphism -174 G/C is associated with nephritis in Portuguese Caucasian systemic lupus erythematosus patientsMaria Jose Santos
Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
Clin Rheumatol 30:409-13. 2011..The IL-6 gene promoter polymorphism at position -174 does not contribute to SLE susceptibility in Portuguese Caucasian patients but may predispose to specific manifestations of the disease...
- Coordinate gene expression of the alpha3, alpha4, and alpha5 chains of collagen type IV. Evidence from a canine model of X-linked nephritis with a COL4A5 gene mutationP S Thorner
Department of Pathology, The Hospital for Sick Children and the University of Toronto, Toronto, Ontario M5G 1X8, Canada
J Biol Chem 271:13821-8. 1996Canine X-linked hereditary nephritis is an animal model for human X-linked hereditary nephritis with a premature stop codon in the alpha5(IV) gene of collagen type IV...
- Resolution of Henoch-Schönlein purpura nephritis after acquired IgA deficiencyMototsugu Tanaka
Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
Pediatr Nephrol 25:2355-8. 2010We report a case of Henoch-Schönlein purpura nephritis (HSPN) with acquired IgA deficiency due to parvovirus B19 infection...
- Protection against autoimmune nephritis in MyD88-deficient MRL/lpr miceAtsushi Sadanaga
Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Arthritis Rheum 56:1618-28. 2007To determine whether innate receptor signals play an important role in the development of autoimmune nephritis in MRL/lpr mice, an experimental model of lupus nephritis.
- IgA nephropathy and Henoch-Schoenlein purpura nephritis: aberrant glycosylation of IgA1, formation of IgA1-containing immune complexes, and activation of mesangial cellsJan Novak
University of Alabama at Birmingham, Department of Microbiology, Birmingham, AL 35294, USA
Contrib Nephrol 157:134-8. 2007..The circulating IgA1 of patients with Henoch-Schoenlein purpura nephritis (HSPN) has a similar defect...
- Clinical and pathological features of children with Henoch-Schoenlein purpura nephritis: risk factors associated with poor prognosisY Kawasaki
Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
Clin Nephrol 60:153-60. 2003To clarify the risk factors related to prognosis in patients with Henoch-Schoenlein purpura nephritis (HSPN), we investigated the cases with HSPN on long-term observation.
- Henoch-SchÃ¶nlein purpura nephritisFernando C Fervenza
Division of Nephrology, Mayo Clinic, Rochester, MN 55905, USA
Int J Dermatol 42:170-7. 2003
- The targets of nephritogenic antibodies in systemic autoimmune disordersP Migliorini
Clinical Immunology Unit, Department of Internal Medicine, University of Pisa, Via Roma 67, 56126 Pisa, Italy
Autoimmun Rev 1:168-73. 2002..Alpha-actinin, an actin-binding protein localized in glomerular podocytes, is the major target of nephritogenic anti-DNA antibodies. Alpha-enolase, a glycolytic enzyme, is a target of nephritogenic anti-DNA and non-anti-DNA antibodies...
- Serum protein oxidation and apolipoprotein CIII levels in people with systemic lupus erythematosus with and without nephritisPhilip E Morgan
Free Radical Group, The Heart Research Institute, Camperdown, Sydeny, Australia
Free Radic Res 41:1301-12. 2007..This study compares serum protein oxidation levels in SLE patients without and with renal involvement (lupus nephritis); the latter have a significantly poorer prognosis...
- Polyomavirus (BK) in pediatric renal transplants: evaluation of viremic patients with and without BK associated nephritisLeonard C Hymes
Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
Pediatr Transplant 10:920-2. 2006..complication in renal transplantation, which may lead to renal dysfunction and graft loss caused by BK nephritis (BKN). We report the management and outcome of 20 children who developed BK viremia...
- Development of nephritis but not sialadenitis in autoimmune-prone BAFF transgenic mice lacking marginal zone B cellsCarrie A Fletcher
Immunology and Inflammation Research Program, The Garvan Institute of Medical Research, Sydney, Australia
Eur J Immunol 36:2504-14. 2006..BAFF transgenic (Tg) mice develop autoimmune disorders characterized by autoantibody production, which leads to nephritis and salivary gland destruction (sialadenitis), features reminiscent of systemic lupus erythematosus and Sjögren'..
- CD134 expression on CD4+ T cells is associated with nephritis and disease activity in patients with systemic lupus erythematosusS Patschan
Department of Nephrology, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany
Clin Exp Immunol 145:235-42. 2006..Eleven patients had biopsy-proven lupus nephritis while 17 patients had no clinical evidence of lupus nephritis...
- Predictors of outcome in Henoch-Schönlein nephritis in children and adultsRosanna Coppo
Nephrology, Dialysis and Transplantation Unit, Regina Margherita Hospital, Turin, Italy
Am J Kidney Dis 47:993-1003. 2006Factors predictive of renal outcome were investigated in 219 cases of biopsy-proven Henoch-Schönlein purpura nephritis (HSPN); 83 children and 136 adults enrolled in a national study were followed up for up to 27 years (median, 4...
- BK virus-specific antibodies and BKV DNA in renal transplant recipients with BKV nephritisSundaram Hariharan
The Division of Nephrology, Medical College of Wisconsin, Milwaukee, WI, USA
Am J Transplant 5:2719-24. 2005We evaluated twenty renal transplant subjects at various stages of BKV nephritis (BKVN) for BKV-specific IgG and IgM antibodies using ELISA technique and BKV-DNA using PCR...
- Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritisEugene T Grygielko
Urogenital Biology, GlaxoSmithKline, King of Prussia, PA 19406, USA
J Pharmacol Exp Ther 313:943-51. 2005..the role of TGF-beta1 in the acute puromycin aminonucleoside (PAN) rat model of renal disease, a model of nephritis-induced renal fibrosis...
- Henoch-SchÃ¶nlein purpura nephritis with nephrotic-range proteinuria: histological regression possibly associated with cyclosporin A and steroid treatmentJ I Shin
Department of Paediatrics, The Institute of Kidney Disease, Yonsei University College of Medicine, Severance Hospital, Seoul, Korea
Scand J Rheumatol 34:392-5. 2005OBJECTIVE: To clarify the therapeutic role of cyclosporin A (CyA) for patients with Henoch-SchÃ¶nlein purpura nephritis (HSPN) showing nephrotic-range proteinuria. METHODS: The clinical and histological findings of eight children (7...
- Prevention and reversal of nephritis in MRL/lpr mice with a single injection of C-reactive proteinWilfredo Rodriguez
University of New Mexico School of Medicine, Albuquerque, NM 87108, USA
Arthritis Rheum 54:325-35. 2006..These mice develop high-titer anti-DNA antibodies and immune complex-mediated nephritis and exhibit progressive lymphadenopathy...
- BK virus nephritis after renal transplantationS Hariharan
Division of Nephrology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Kidney Int 69:655-62. 2006BK viremia and nephritis are increasing problems in renal transplant recipients. The exact cause of the increasing prevalence of this condition remains poorly understood...
- SLEN2 (2q34-35) and SLEN1 (10q22.3) replication in systemic lupus erythematosus stratified by nephritisAna I Quintero-del-Rio
Am J Hum Genet 75:346-8. 2004
- Coincident scrapie infection and nephritis lead to urinary prion excretionHarald Seeger
Institute of Neuropathology, , Schmelzbergstrasse 12, , Switzerland
Science 310:324-6. 2005..Urinary proteins from scrapie-infected mice with lymphocytic nephritis induced scrapie upon inoculation into noninfected indicator mice...
- Streptococcal origin of a case of Henoch-Schoenlein purpura nephritisY Kikuchi
Second Department of Internal Medicine, National Defense Medical College, Namiki, Tokorozawa, Saitama, Japan
Clin Nephrol 65:124-8. 2006..occurring 2 weeks after acute tonsillitis, and admitted to our hospital with suspected Henoch-Schönlein purpura nephritis (HSPN). He had increased anti-streptolysin O (ASO) titer and hypocomplementemia...
- Risk factors for BK polyomavirus nephritis in renal allograft recipientsPaulo N Rocha
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Clin Transplant 18:456-62. 2004..AR) and/or the intense immunosuppression used for their treatment have been proposed as risk factors for BK nephritis (BKN; BK refers to the initials of the first patient from whom this polyomavirus was isolated)...
- Nephritis-associated plasmin receptor and acute poststreptococcal glomerulonephritis: characterization of the antigen and associated immune responseNobuyuki Yoshizawa
Department of Public Health, National Defense Medical College, Saitama, Japan
J Am Soc Nephrol 15:1785-93. 2004The role of nephritis-associated antigen as a virulence factor for acute poststreptococcal glomerulonephritis (APSGN) remains to be fully clarified...
- Pathology and protection in nephrotoxic nephritis is determined by selective engagement of specific Fc receptorsYoshikatsu Kaneko
Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY 10021, USA
J Exp Med 203:789-97. 2006..These results establish the significance of specific IgG subclasses and their cognate FcgammaRs in renal disease...
- Henoch-Schönlein purpura nephritis: course of disease and efficacy of cyclophosphamidePenina Tarshish
Albert Einstein College of Medicine, Bronx, New York 10461, USA
Pediatr Nephrol 19:51-6. 2004b>Nephritis in Henoch-Schönlein purpura (HSP) is the primary cause of morbidity and mortality. Although many therapeutic regimens have been reported to be effective, no therapy has been shown in a controlled trial to be beneficial...
- Possible pathologenic role of interleukin-5 and eosino cationic protein in Henoch-Schönlein purpura nephritisYukihiko Kawasaki
Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan
Pediatr Int 47:512-7. 2005The mechanism for the onset of Henoch-Schönlein purpura nephritis is unknown...
- Prevention of mercuric chloride-induced nephritis in the brown Norway rat by treatment with antibodies against the alpha 4 integrinA Molina
Department of Pathology, , Madrid, Spain
J Immunol 153:2313-20. 1994HgCl2 induces the synthesis of anti-GBM Abs with the development of glomerular and interstitial nephritis, as well as proteinuria, in the Brown Norway rat...
- Nitric oxide inhibition enhances platelet aggregation in experimental anti-Thy-1 nephritisH van Goor
Department of Pathology and Laboratory Medicine, University Hospital Groningen, Groningen, The Netherlands
Nitric Oxide 5:525-33. 2001..Urinary protein excretion was significantly elevated in Thy-1 nephritis at 3 and 7 days...
- The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritisKirsten Neubert
Interdisciplinary Center for Clinical Research, research group N2, Nikolaus Fiebiger Center of Molecular Medicine, University Hospital Erlangen, Glückstrasse 6, 91054 Erlangen, Germany
Nat Med 14:748-55. 2008..Hence, the elimination of autoreactive plasma cells by proteasome inhibitors might represent a new treatment strategy for antibody-mediated diseases...
- Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritisSteven D Crowley
Department of Medicine, Division of Nephrology, Duke University Medical Center, and Durham VA Medical Center, Durham, North Carolina 27705, USA
J Clin Invest 119:943-53. 2009..Since AT1A-deficient lpr mice had low blood pressure, these findings suggest that activation of type 1 angiotensin receptors in the glomerulus is sufficient to accelerate renal injury and inflammation in the absence of hypertension...
- Analysis and classification of B-cell infiltrates in lupus and ANCA-associated nephritisOliver M Steinmetz
III Medizinische Klinik, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
Kidney Int 74:448-57. 2008..Therefore we characterized intrarenal lymphoid clusters of 32 patients diagnosed with lupus nephritis and 16 with ANCA associated nephritis...
- Genome sequence of a Lancefield group C Streptococcus zooepidemicus strain causing epidemic nephritis: new information about an old diseaseStephen B Beres
Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, Texas, USA
PLoS ONE 3:e3026. 2008..zooepidemicus strain MGCS10565, a group C organism that caused a very large and unusually severe epidemic of nephritis in Brazil. The genome is a circular chromosome of 2,024,171 bp...
- Treatment-based literature of Henoch-Schönlein purpura nephritis in childhoodMarco Zaffanello
Department of Mother Child and Biology Genetics, University of Verona, 37134 Verona, Italy
Pediatr Nephrol 24:1901-11. 2009..of identifying an improved therapeutic protocol for use in the treatment of childhood Henoch-Schönlein purpura nephritis, primarily due to the unpredictable success shown to date in improving long-term renal outcome...
- Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosusCarlos Geraldo Moura
Hospital Santo Antonio, Escola Bahiana de Medicina e Saude Publica, Salvador, Brazil
J Clin Lab Anal 23:19-23. 2009Anti-C1q antibodies have been described in systemic lupus erythematosus (SLE) as well as in other connective tissue diseases. They have been considered as a marker for disease activity and presence of nephritis.
- Epidemic nephritis in Nova Serrana, BrazilS Balter
Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Lancet 355:1776-80. 2000Outbreaks of nephritis have been rare since the 1970s. From December, 1997, to July, 1998, 253 cases of acute nephritis were identified in Nova Serrana, Brazil. Seven patients required dialysis, and three patients died...
- Functional relevance of activated beta1 integrins in mercury-induced nephritisE Escudero
Department of Pathology, , , Madrid, Spain
J Am Soc Nephrol 11:1075-84. 2000..synthesis and glomerular deposits of anti-glomerular basement membrane antibodies, proteinuria, and interstitial nephritis. Using the mercury model of nephritis, it was found that the expression of HUTS-21 epitope is induced in vivo in ..
- Complement activation through the lectin pathway in patients with Henoch-Schönlein purpura nephritisM Endo
Second Department of Internal Medicine, Nihon University School of Medicine, Tokyo
Am J Kidney Dis 35:401-7. 2000Henoch-Schönlein purpura nephritis (HSPN) is considered a form of systemic vasculitis of the small blood vessels with immune pathogenesis...
- A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupusO T Chan
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Exp Med 189:1639-48. 1999..These mice developed nephritis, characterized by cellular infiltration within the kidney, indicating that B cells themselves, without soluble ..
- Lack of effect of a single injection of human C-reactive protein on murine lupus or nephrotoxic nephritisFrancesco Carlucci
Imperial College London, London, UK
Arthritis Rheum 62:245-9. 2010..of spontaneous lupus, as well as the rapid-onset immune complex disease induced in the accelerated nephrotoxic nephritis (ANTN) model...
- Renal expression of alpha-smooth muscle actin and c-Met in children with Henoch-Schönlein purpura nephritisYukihiko Kawasaki
Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga oka, Fukushima City, Fukushima 960 1295, Japan
Pediatr Nephrol 23:913-9. 2008..whether alpha-SMA and HGF are associated with the progression of renal injury in Henoch-Schönlein purpura nephritis (HSPN), we evaluated the renal expression of alpha-SMA and c-Met in HSPN patients...
- Noninvasive diagnosis of BK virus nephritis by measurement of messenger RNA for BK virus VP1 in urineRuchuang Ding
Division of Nephrology, Departments of Medicine and Transplantation Medicine, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10021, USA
Transplantation 74:987-94. 2002Polyoma virus type BK (BKV) nephritis has emerged as an important cause of renal allograft dysfunction and graft failure. Its diagnosis is contingent on the invasive procedure of allograft biopsy...
- Chemokine receptor CXCR3 mediates T cell recruitment and tissue injury in nephrotoxic nephritis in miceUlf Panzer
Medizinische Klinik III, Zentrum fur Innere Medizin, University of Hamburg, Martinistrasse 52, Hamburg, Germany
J Am Soc Nephrol 18:2071-84. 2007..testing whether CXCR3 plays a role in renal inflammation, CXCR3-deficient mice were generated and nephrotoxic nephritis was induced in C57BL/6 CXCR3(-/-) and C57BL/6 wild-type mice...
- Association of angiotensin-converting enzyme polymorphisms with systemic lupus erythematosus and nephritis: analysis of 644 SLE familiesA Parsa
Division of Nephrology, Department of Medicine, University of California, San Francisco, CA, USA
Genes Immun 3:S42-6. 2002Angiotensin II is a strong candidate for the perpetuation of autoimmunity, nephritis and visceral damage in systemic lupus erythematosus (SLE)...
- Syndecan-1 deficiency aggravates anti-glomerular basement membrane nephritisA L Rops
Nephrology Research Laboratory, Division of Nephrology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Kidney Int 72:1204-15. 2007During the heterologous phase of experimental anti-glomerular basement membrane (anti-GBM) nephritis, leukocyte influx peaks within hours, whereas albuminuria occurs within 1 day...
- Acute focal bacterial nephritis in 25 childrenTanja Seidel
Universitaetsklinikum Münster, University Children s Hospital, Munster, Germany
Pediatr Nephrol 22:1897-901. 2007Acute focal bacterial nephritis (AFBN), formerly known as lobar nephronia, is a rare form of interstitial bacterial nephritis. Most often described in adults with diabetes, there is only limited knowledge of AFBN in children...
- Low incidence of BK virus nephropathy after simultaneous kidney pancreas transplantationGaurav Gupta
Department of Pediatrics, Children's Hospital of Pittsburgh, PA 15213, USA
Transplantation 82:382-8. 2006..The underlying reasons may include less toxic immunosuppressive protocols, earlier diagnosis and the use of antiviral therapy...
- Lack of association between NPHS2 gene polymorphisms and Henoch-Schönlein purpura nephritisYang Zhang
Department of Epidemiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, PR China
Arch Dermatol Res 299:151-5. 2007..HSP) is one of the most common forms of small-vessel vasculitis in childhood, and renal involvement (HSP nephritis, HSPN) is the main determinant of morbidity after acute phase...
- [Virus, immunosuppression, and the kidney transplant recipient]Josefina Alberu
Departamento de Trasplantes, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Rev Invest Clin 57:582-95. 2005
- Sudden late onset of gross hematuria in a previous renal transplant recipient 3 months after transplant nephrectomyLisa Nanovic
Department of Transplant Surgery, University of Wisconsin, Fitchburg, WI 53713, USA
Am J Kidney Dis 46:e91-4. 2005..We present an interesting and unusual cause of painless gross hematuria in a patient with end-stage renal disease and transplant nephrectomy 3 months before the onset of bleeding...
- [Role of mast cells in the development of renal interstitial fibrosis in children with Henoch-Schonlein purpura nephritis]Gao Ping Zhang
Department of Respiratory, Children s Hospital of Jiangxi Province, Nanchang, China
Zhongguo Dang Dai Er Ke Za Zhi 9:125-8. 2007To investigate the role of mast cells in the development of renal interstitial fibrosis in children with Henoch-Schonlein purpura nephritis (HSPN) and possible mechanisms.
- [Relationship between clinical manifestations and renal pathology in children with Henoch-Schonlein purpura nephritis]Guo Zhen Zhang
Laboratory of Pediatric Nephrology, Second Xiangya Hospital of Central South University, Changsha, China
Zhongguo Dang Dai Er Ke Za Zhi 9:129-32. 2007..investigated the clinical manifestations and renal pathological findings of 95 children with Henoch-Schonlein purpura nephritis (HSPN) in order to explore the relationship between clinical manifestations and renal pathology in HSPN.
- Epizootic occurrence of haemorrhagic nephritis enteritis virus infection of geeseVilmos Palya
CEVA Phylaxia Biologicals Co Ltd Szállás utca 5 H 1107 Budapest
Avian Pathol 33:244-50. 2004Recent outbreaks of haemorrhagic nephritis enteritis in geese flocks of 3 to 10 weeks in age in Hungary were investigated. Mortality varied between 4% and 67%. Affected birds generally died suddenly...
- Renal inflammation is modulated by potassium in chronic kidney disease: possible role of Smad7Wansheng Wang
Dept of Medicine Renal Section, Baylor College of Medicine, Houston, TX 77030, USA
Am J Physiol Renal Physiol 293:F1123-30. 2007..Our results show that potassium supplementation can reduce renal inflammation and hence, could modulate the progression of kidney injury in CKD...
- BK virus nephritis: risk factors, timing, and outcome in renal transplant recipientsBrahm Vasudev
Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Kidney Int 68:1834-9. 2005BACKGROUND: BK virus nephritis (BKVN) has emerged as an important cause of renal transplant failure. Quantified analysis of its timing and clinical course is generally lacking...
- [Evaluation of prednisone treatment in children with IgA nephropathy and SchÃ¶nlein-Henoch nephropathy according to the Waldo protocol with regard to pathomorphologic changes in renal biopsy]H Szymanik-Grzelak
Katedra i Klinika Pediatrii i Nefrologii Akademi Medycznej w Warszawie
Pol Merkur Lekarski 10:259-62. 2001..Nephrol. 1993, 7, 529) in children with IgA nephropathy (IgAN) and SchÃ¶nlein-Henoch nephritis (HSN). Eight pts: 6 with IgAN, mean age 10.1 yrs and 2 with HSN aged 10.3 and 14...
- Successful pregnancy in renal transplant recipient with previous known polyomavirus nephropathyKarsten Midtvedt
Department of Nephrology, Rikshospitalet Radiumhospitalet Medical Centre, Oslo, Norway
Clin Transplant 21:571-3. 2007..v. To our knowledge, this is the first published experience with a successful pregnancy in renal transplant recipients with known history of polyomavirus-associated nephropathy...
- Effects of Bupleurum scorzoneraefolium, Bupleurum falcatum, and saponins on nephrotoxic serum nephritis in miceS M Chen
Department of Clinical Pharmacy, Taipei Medical University, Taipei 110, Taiwan, Republic of China
J Ethnopharmacol 116:397-402. 2008..whether two of these species, Bupleurum scorzoneraefolium and Bupleurum falcatum, or their active ingredients, saikosaponins a, c, and d, could prevent the development of immune-complex nephritis in nephrotoxic serum treated mice.
- [Polyoma virus BK nephropathy in kidney allograft recipients]Bartłomiej Matłosz
Klinika Medycyny Transplantacyjnej i Nefrologii, Instytut Transplantologii Akademii Medycznej w Warszawie
Przegl Epidemiol 60:133-40. 2006Polyomavirus BK (BKV) infection is a fast growing problem in modern transplantation medicine. Interstitial nephritis is the most important pathology caused by the virus leading to graft failure and the need for dialysis treatment...
- Polyomavirus-associated nephropathy: update in diagnosisC B Drachenberg
Department of Pathology, University of Maryland School of Medicine, Baltimore, 21201, USA
Transpl Infect Dis 8:68-75. 2006The histological diagnosis of BK or JC polyomavirus allograft nephritis (PVAN) requires evaluation of a renal biopsy with demonstration of the polyomavirus cytopathic changes and confirmation with an ancillary technique such as ..
- BK virus nephritis after renal transplantationAaron Dall
Division of Nephrology, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
Clin J Am Soc Nephrol 3:S68-75. 2008BK virus nephritis is an increasing problem and is posing a threat to improving renal transplant graft survival. The pathogenesis of this condition remains to be investigated...
- [Purpura Schoenlein-Henoch: results of the Wörlitz 2005 Consensus Conference focusing on diagnosis and therapy]T Hospach
Olgahospital Stuttgart, Pädiatrie 1, Stuttgart, Germany
Klin Padiatr 220:47-52. 2008..Skin, bowel and joints are characteristically involved. Although renal manifestations are common PSH-nephritis is infrequent but characterized by a poor prognosis...
- HGF gene therapy attenuates renal allograft scarring by preventing the profibrotic inflammatory-induced mechanismsI Herrero-Fresneda
Laboratory of Experimental Nephrology, Department of Medicine, IDIBELL Hospital Universitari de Bellvitge, Barcelona, Spain
Kidney Int 70:265-74. 2006..The effectiveness of HGF-gene therapy in the prevention of renal allograft scarring is related with the halt of profibrotic inflammatory-induced mechanisms...
- The natural history, risk factors and outcomes of polyomavirus BK-associated nephropathy after renal transplantationHans H Hirsch
University of Basel, Switzerland
Nat Clin Pract Nephrol 2:240-1. 2006
- [Henoch-Schönlein purpura]Evangeline Pillebout
Service de néphrologie et de transplantation, Hopital Saint Louis, Paris
Rev Prat 58:507-11. 2008..The main clinical features include cutaneous purpura, arthritis and gastrointestinal symptoms. Nephritis may occur, typically a glomerulonephritis with IgA mesangial deposits...
- A case of polyomavirus-associated nephropathy presenting late after transplantationShweta Bansal
University of Colorado at Denver Health Sciences Center, Department of Renal Disease and Hypertension, 1635 North Ursula Street, Mail Stop F749, PO Box 6510, Denver, CO 80045, USA
Nat Clin Pract Nephrol 4:283-7. 2008..Potential etiologies such as acute T-cell-mediated rejection, acute and chronic antibody-mediated rejection, polyomavirus-associated nephropathy, and calcineurin inhibitor nephrotoxicity were considered...
- Rapid and sensitive electrophoresis of urinary protein clearly reveals the pathophysiological feature of renal diseasesMinoru Sakatsume
Division of Clinical Nephrology and Rheumatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
Nephrology (Carlton) 12:191-6. 2007..However, this method has not been used routinely because of its difficulty in obtaining a clear image. This study was performed in order to re-evaluate this method with an improved system...
- Nephritogenic lupus antibodies recognize glomerular basement membrane-associated chromatin fragments released from apoptotic intraglomerular cellsManar Kalaaji
Department of Biochemistry, Institute of Medical Biology, University of Troms, N-9037 Troms, Norway
Am J Pathol 168:1779-92. 2006..Subpopulations of these antibodies are involved in lupus nephritis. No known marker separates nephritogenic from non-nephritogenic anti-dsDNA antibodies...
- Successful treatment of progressive Henoch-SchÃ¶nlein purpura nephritis with tonsillectomy and steroid pulse therapyHitoshi Sugiyama
Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry
Intern Med 44:611-5. 2005..We report here an adult patient with HSP nephritis (HSPN) accompanied by persistent proteinuria and progressive renal dysfunction despite conventional therapy...
- Angiotensin II type 1 receptor blockade attenuates renal fibrogenesis in an immune-mediated nephritic kidney through counter-activation of angiotensin II type 2 receptorHirokazu Okada
Department of Nephrology, Saitama Medical College, Saitama, Japan
Biochem Biophys Res Commun 314:403-8. 2004..roles of angiotensin II (Ang II) type 1 receptor (AT(1)R) and Ang II type 2 receptor (AT(2)R) in immune-mediated nephritis are unknown, and the effect of the blockade of AT(1)R and its indirect counter-activation of AT(2)R relative to ..
- [Renal biopsy: standard procedure of modern nephrology]M Pechula Thut
Abteilung für Nephrologie Hypertonie, Kantonsspital Basel
Ther Umsch 59:110-6. 2002..The procedure is performed ambulatory or during a short hospital stay and the patient can usually be discharged after a monitoring period of eight hours...
- Role of xanthine oxidoreductase in experimental acute renal-allograft rejectionKai Sun
Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany
Transplantation 77:1683-92. 2004..The study was conducted (1). to determine ROS production as well as oxidant and antioxidant enzyme activities in renal grafts and (2). to modulate acute rejection by tungsten administration, a specific inhibitor of XOR...
- Chronic anti-Thy-1 nephritis is aggravated in the nonclipped but not in the clipped kidney of Goldblatt hypertensive ratsUlrich O Wenzel
Division of Nephrology, Department of Medicine, University Hospital Hamburg Eppendorf, Hamburg, Germany
Kidney Int 61:2119-31. 2002We have previously shown that renovascular hypertension does not inhibit healing of the acute Thy-1 nephritis. To test whether a chronic model of the Thy-1 nephritis is more susceptible to high blood pressure, the repetitive hit model ..
- Efficacy of methylprednisolone and urokinase pulse therapy combined with or without cyclophosphamide in severe Henoch-Schoenlein nephritis: a clinical and histopathological studyYukihiko Kawasaki
Fukushima Medical University School of Medicine, 1 Hikariga oka, Fukushima City, Fukushima 960 1295, Japan
Nephrol Dial Transplant 19:858-64. 2004..studies of combined therapy with multiple drugs, including immunosuppressives, for severe Henoch-Schoenlein nephritis (HSPN)...
- Pattern of renal beta 1(alpha 1-alpha 6) integrins distribution in IgA nephropathy and Henoch-Schoenlein nephritisMałgorzata Wagrowska-Danilewicz
Department of Pathomorphology, Nephropathology Division, Medical University, Łódź
Pol J Pathol 53:51-7. 2002..alpha 6 beta 1 on renal biopsy specimens from patients with IgA nephropathy (IgAN, n = 15) and Henoch-Schoenlein nephritis (HSN, n = 10)...
- Cyclooxygenase-2 (COX-2) inhibition limits abnormal COX-2 expression and progressive injury in the remnant kidneyClarice Kazue Fujihara
Renal Division, Department of Clinical Medicine, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
Kidney Int 64:2172-81. 2003..We investigated in the 5/6 nephrectomy model (1) the renal distribution of COX-2; (2) the hemodynamic and cellular mechanisms by which chronic COX-2 inhibition prevents renal injury...
- Monocyte chemoattractant protein-1 (MCP-1) in the kidney: does it more than simply attract monocytes?Christiane Viedt
Nephrol Dial Transplant 17:2043-7. 2002
- Treatment of refractory BK virus-associated nephropathy with cidofovirPradeep V Kadambi
Department of Internal Medicine, Pathology, University of Chicago, Chicago, IL, USA
Am J Transplant 3:186-91. 2003..Prospective, controlled trials are warranted to further define the optimal dose, toxicity and potential role of cidofovir in renal transplant recipients with BK virus nephropathy...
- Macrophages act as effectors of tissue damage in acute renal allograft rejectionMatthew D Jose
Department of Nephrology, Monash Medical Centre, Clayton, Victoria, Australia
Transplantation 76:1015-22. 2003..Macrophages constitute 38% to 60% of infiltrating cells during acute renal allograft rejection. Their contribution to tissue damage during acute rejection was examined by depleting macrophages in a rat model...
- BK polyoma virus allograft nephropathy: ultrastructural features from viral cell entry to lysisCinthia B Drachenberg
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA
Am J Transplant 3:1383-92. 2003..The observed ultrastructural interactions between the BK virions and host cells are remarkably similar to viral cell entry and nuclear targeting described for SV40 virus...
- Polyomavirus in kidney and kidney-pancreas transplant recipientsJ Trofe
Division of Transplantation, Department of Surgery, University of Cincinnati, Cincinnati, OH 45267, USA
Transpl Infect Dis 5:21-8. 2003PURPOSE: To report the incidence and clinical characteristics of polyomavirus (PV) nephritis in kidney (KTX) and kidney-pancreas transplant (KPTX) recipients...
- Efficacy of methylprednisolone and urokinase pulse therapy for severe Henoch-Schönlein nephritisYukihiko Kawasaki
Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
Pediatrics 111:785-9. 2003To evaluate the efficacy of methylprednisolone and urokinase pulse therapy (MUPT) for severe Henoch-Schönlein nephritis, we examined the clinical manifestation and prognosis of patients with MUPT on long-term observation.
- Effects of mycophenolate mofetil in mercury-induced autoimmune nephritisElena Nieto
Department of Pathology, , Universidad de Alcal, Carretera Colmenar km 9.100, Madrid 29034, Spain
J Am Soc Nephrol 13:937-45. 2002..In this study, the effect of MMF in the mercury model of nephritis was examined...
- Polyomavirus nephropathy in renal transplantation: a clinico-pathological studyHyeon Joo Jeong
Department of Pathology, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun Ku, 120 752, Seoul, Korea
Transpl Int 16:671-5. 2003..Further studies will be required to find a better marker for coexisting AR in patients with PV nephropathy and to establish strategies for treatment...
- Clinical ComponentBRIAN KOTZIN; Fiscal Year: 2003..ACE includes groups doing clinical investigation on type 1 diabetes, systemic lupus erythematosus and lupus nephritis, rheumatoid arthritis, systemic sclerosis, multiple sclerosis, autoimmune pulmonary diseases including ..
- ADHESION MOLECULES AND GLOMERULONEPHRITISTANYA MAYADAS NORTON; Fiscal Year: 2000..in murine models of glomerulonephritis developed by our group: acute, passive anti- glomerular basement membrane nephritis, complement dependent acute nephrotoxic serum nephritis and accelerated nephrotoxic serum nephritis associated ..
- PATHOGENIC ROLE OF THE COMPLEMENT SYSTEM IN MURINE LUPUSRichard Quigg; Fiscal Year: 2009..circumstantial and now direct evidence that the complement system is involved in the pathogenesis of lupus nephritis. The work proposed in this application will examine the role of the complement system in renal disease occurring ..
- Molecular pathogenesis of anti-glomerular basement membrane nephritisDorin Bogdan Borza; Fiscal Year: 2009..in health, broken in autoimmune anti-GBM disease, or selectively deficient in alloimmune Alport post-transplant nephritis. The objective of this project is to determine at molecular level how the adaptive immune system is abnormally ..
- Molecular pathogenesis of anti-glomerular basement membrane nephritisDorin Bogdan Borza; Fiscal Year: 2010..in health, broken in autoimmune anti-GBM disease, or selectively deficient in alloimmune Alport post-transplant nephritis. The objective of this project is to determine at molecular level how the adaptive immune system is abnormally ..
- Prediction of Lupus Outcome by Gene Expression PatternsRobert Winchester; Fiscal Year: 2006..parent trial compares administration of CellCept versus IV Cytoxan for initiating control of biopsy-proven lupus nephritis. We have demonstrated the feasibility of studying gene expression profiles by microarray analysis in glomeruli ..
- The Renal Pathogenicity of Anti-DNA AntibodiesChaim Putterman; Fiscal Year: 2009..specific for systemic lupus erythematosus (SLE), but are also directly involved in the pathogenesis of lupus nephritis (LN), a major disease manifestation...
- The Renal Pathogenicity of Anti-DNA AntibodiesChaim Putterman; Fiscal Year: 2010..specific for systemic lupus erythematosus (SLE), but are also directly involved in the pathogenesis of lupus nephritis (LN), a major disease manifestation...
- The Renal Pathogenicity of Anti-DNA AntibodiesChaim Putterman; Fiscal Year: 2009..specific for systemic lupus erythematosus (SLE), but are also directly involved in the pathogenesis of lupus nephritis (LN), a major disease manifestation...
- ROLE OF PPAR GAMMA IN LUPUS NEPHRITISGary Gilkeson; Fiscal Year: 2005..important insight into the role of PPAR gamma and its ligands in controlling the inflammatory response in lupus nephritis. We and others have shown that the inflammatory response in lupus nephritis can be blocked, decreasing ..
- CELL MEDIATED RENAL INJURY IN LUPUSVICKI KELLEY; Fiscal Year: 2004..renal disease regulated by the lpr gene we will investigate the importance of CSF-1 in the pathogenesis of lupus nephritis. We propose to test whether the increase in circulating CSF-1 detected in neonatal MRL-lpr/lpr mice is ..
- CLINICAL CENTERDavid Wofsy; Fiscal Year: 2003..The two proposed clinical trials are: Protocol 1: Treatment of lupus nephritis with CTLA4Ig, a fusion protein that inhibits T cell costimulation via the CD28 pathway...
- Cellular and Genetic Basis of Systemic LupusShu Man Fu; Fiscal Year: 2010..of chronic glomerulonephritis (cGN) respectively in NZM2328, a much studied model for human proliferative lupus nephritis. During the currrent grant period, two informative congenic lines, 290-2 and 507-2 were generated and ..
- Human Autoantibodies in Anti-GBM DiseaseAnne Christensen; Fiscal Year: 2005..The studies proposed here seek to identify how autoantibodies against alpha3(IV) initiate nephritis through binding to the GBM...
- RCT of GnRH-a for ovarian protection during CYC therapy for rheumatic diseaseWILLIAM J contact MC CUNE; Fiscal Year: 2010..according to evidence-based protocols for treatment of severe rheumatic diseases including lupus nephritis, Wegener's granulomatosis, other forms of pauci-immune vasculitis, and severe interstitial lung disease ..
- Biomarkers Based Studies of PolyomavirusesAbhay Vats; Fiscal Year: 2007..In patients with BKV-associated tubulointerstitial nephritis, a significant risk for graft loss was noted in our studies...
- Role of Focal Adhesion Kinase (FAK) in Nephrosis and NephritisShuta Ishibe; Fiscal Year: 2010..The goal of the proposal is to define the mechanisms that are involved during kidney injury and to utilize inhibitors that antagonize against the offending agent(s) responsible for disease progression. ..
- Inhibition of lupus nephritis in IRF-1 deficient miceChristopher Reilly; Fiscal Year: 2002..The specific aims described below investigate the role of IFN-y signaling and define the role of IRF-1 in lupus nephritis in MRL/lpr mice...
- Cellular and Genetic Basis of Systemic LupusShu Man Fu; Fiscal Year: 2004..detected in SLE and the genetic factors important in the generation of ANA and anti-dsDNA antibodies and lupus nephritis. Recently, a new model of SLE NZM2328 has been characterized...
- Tertiary lymphoid neogenesis in human lupus nephritisMarcus R Clark; Fiscal Year: 2010The most frequent severe manifestation of SLE is lupus nephritis (LN)...
- Role of reactive intermediates in lupus nephritisJames C Oates; Fiscal Year: 2010Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is complicated by lupus nephritis (LN) in approximately 50 percent of cases...
- IMMUNOLOGIC MECHANISMS OF LUPUS NEPHRITISMichael Madaio; Fiscal Year: 1993..per se, are critical for and contribute to the observed variations in the phenotypic expression of lupus nephritis, and they emphasize the disease relevance of both the Ag binding regions of pathogenic autoAb and the glomerular ..
- Sociodemographic Disparities in Lupus Nephritis: Healthcare Access and OutcomesKaren Costenbader; Fiscal Year: 2009..S. Systemic lupus erythematosus (lupus), a complex autoimmune disease, can cause nephritis and, in severe cases, end-stage renal disease...
- Membranous Nephritis Antigen Defined by Phage AntibodiesSudesh Makker; Fiscal Year: 2007..when patients first present with full-blown nephrotic syndrome is supported by similar observation in Heymann nephritis, a rat model of MGN...