nephritis

Summary

Summary: Inflammation of the kidney. It is a focal or diffuse proliferative or destructive process which may involve the glomerulus, tubule, or interstitial renal tissue. (Dorland, 27th ed)

Top Publications

  1. doi The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis
    Kirsten Neubert
    Interdisciplinary Center for Clinical Research, research group N2, Nikolaus Fiebiger Center of Molecular Medicine, University Hospital Erlangen, Glückstrasse 6, 91054 Erlangen, Germany
    Nat Med 14:748-55. 2008
  2. ncbi Opposite regulation of type II and III receptors for immunoglobulin G in mouse glomerular mesangial cells and in the induction of anti-glomerular basement membrane (GBM) nephritis
    Heinfried H Radeke
    Department of Clinical Immunology and Institute of Pharmacology, Medical School of Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Biol Chem 277:27535-44. 2002
  3. pmc Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis
    Vadim Pedchenko
    Center for Matrix Biology, Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    N Engl J Med 363:343-54. 2010
  4. pmc Paricalcitol inhibits renal inflammation by promoting vitamin D receptor-mediated sequestration of NF-kappaB signaling
    Xiaoyue Tan
    Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Am Soc Nephrol 19:1741-52. 2008
  5. ncbi BK virus nephritis after renal transplantation
    S Hariharan
    Division of Nephrology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Kidney Int 69:655-62. 2006
  6. ncbi Protection against autoimmune nephritis in MyD88-deficient MRL/lpr mice
    Atsushi Sadanaga
    Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Arthritis Rheum 56:1618-28. 2007
  7. pmc Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice
    A M Jevnikar
    Robarts Research Institute, University of Western Ontario, London, Canada
    J Exp Med 179:1137-43. 1994
  8. pmc OX40/OX40L in systemic lupus erythematosus: association with disease activity and lupus nephritis
    Mohamed N Farres
    Department of Internal Medicine, Allergy and Clinical Immunology, Ain Shams University, Cairo, Egypt
    Ann Saudi Med 31:29-34. 2011
  9. ncbi Henoch-Schönlein purpura nephritis complicated by reversible posterior leukoencephalopathy syndrome
    Daimei Sasayama
    Third Department of Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Clin Rheumatol 26:1761-3. 2007
  10. doi Henoch-Schonlein purpura nephritis: pathophysiology, treatment, and future strategy
    Jean Claude Davin
    Department of Pediatric Nephrology, Emma Children s Hospital Academic Medical Center, Amsterdam, The Netherlands
    Clin J Am Soc Nephrol 6:679-89. 2011

Research Grants

Detail Information

Publications223 found, 100 shown here

  1. doi The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis
    Kirsten Neubert
    Interdisciplinary Center for Clinical Research, research group N2, Nikolaus Fiebiger Center of Molecular Medicine, University Hospital Erlangen, Glückstrasse 6, 91054 Erlangen, Germany
    Nat Med 14:748-55. 2008
    ..Hence, the elimination of autoreactive plasma cells by proteasome inhibitors might represent a new treatment strategy for antibody-mediated diseases...
  2. ncbi Opposite regulation of type II and III receptors for immunoglobulin G in mouse glomerular mesangial cells and in the induction of anti-glomerular basement membrane (GBM) nephritis
    Heinfried H Radeke
    Department of Clinical Immunology and Institute of Pharmacology, Medical School of Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Biol Chem 277:27535-44. 2002
    ..In a passive model of acute anti-glomerular basement membrane (GBM) nephritis, induction of FcgammaRIII and suppression of FcgammaRII occurred in kidney tissues...
  3. pmc Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis
    Vadim Pedchenko
    Center for Matrix Biology, Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    N Engl J Med 363:343-54. 2010
    ..Alport's post-transplantation nephritis, which is mediated by alloantibodies against the GBM, occurs after kidney transplantation in some patients with ..
  4. pmc Paricalcitol inhibits renal inflammation by promoting vitamin D receptor-mediated sequestration of NF-kappaB signaling
    Xiaoyue Tan
    Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Am Soc Nephrol 19:1741-52. 2008
    ..These results suggest that paricalcitol inhibits renal inflammatory infiltration and RANTES expression by promoting VDR-mediated sequestration of NF-kappaB signaling...
  5. ncbi BK virus nephritis after renal transplantation
    S Hariharan
    Division of Nephrology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Kidney Int 69:655-62. 2006
    BK viremia and nephritis are increasing problems in renal transplant recipients. The exact cause of the increasing prevalence of this condition remains poorly understood...
  6. ncbi Protection against autoimmune nephritis in MyD88-deficient MRL/lpr mice
    Atsushi Sadanaga
    Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Arthritis Rheum 56:1618-28. 2007
    To determine whether innate receptor signals play an important role in the development of autoimmune nephritis in MRL/lpr mice, an experimental model of lupus nephritis.
  7. pmc Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice
    A M Jevnikar
    Robarts Research Institute, University of Western Ontario, London, Canada
    J Exp Med 179:1137-43. 1994
    ..Whereas non-MHC linked genes can have a profound effect on the development of nephritis, lymphadenopathy, and anti-DNA antibody production in MRL-lpr mice, the role of MHC molecules has not been ..
  8. pmc OX40/OX40L in systemic lupus erythematosus: association with disease activity and lupus nephritis
    Mohamed N Farres
    Department of Internal Medicine, Allergy and Clinical Immunology, Ain Shams University, Cairo, Egypt
    Ann Saudi Med 31:29-34. 2011
    OX40-OX40L interaction is implicated in the pathogenesis of systemic lupus erythematosus (SLE). We evaluated the role of OX40/OX40L as markers of disease activity and nephritis in SLE patients.
  9. ncbi Henoch-Schönlein purpura nephritis complicated by reversible posterior leukoencephalopathy syndrome
    Daimei Sasayama
    Third Department of Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Clin Rheumatol 26:1761-3. 2007
    We report a young female patient with Henoch-Schönlein purpura (HSP) nephritis complicated by reversible posterior leukoencephalopathy syndrome (RPLS)...
  10. doi Henoch-Schonlein purpura nephritis: pathophysiology, treatment, and future strategy
    Jean Claude Davin
    Department of Pediatric Nephrology, Emma Children s Hospital Academic Medical Center, Amsterdam, The Netherlands
    Clin J Am Soc Nephrol 6:679-89. 2011
    Henoch-Schönlein purpura nephritis is a rare kidney disease leading to chronic kidney disease in a non-negligible percentage of patients...
  11. ncbi Induction of nephrotoxic serum nephritis in inbred mice and suppressive effect of colchicine on the development of this nephritis
    Shih Ming Chen
    Department of Drug Information and Communication, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba shi, Japan
    Pharmacol Res 45:319-24. 2002
    Accelerated nephrotoxic serum (NTS) nephritis is successfully produced in C57BL/6 mice, using anti-murine glomerular basement membrane (GBM) rabbit antiserum...
  12. ncbi Involvement of mesangial cells expressing alpha-smooth muscle actin during restorative glomerular remodeling in Thy-1.1 nephritis
    Koichiro Ichimura
    Department of Anatomy, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Histochem Cytochem 54:1291-301. 2006
    ..In addition, an actin-binding protein, drebrin, was localized in all MC processes extending toward various directions throughout the course of nephritis, suggesting that drebrin is involved in the formation of MC processes.
  13. ncbi Effects of allopurinol treatment on the progression of chronic nephritis in Canine leishmaniosis (Leishmania infantum)
    K Plevraki
    Clinic of Companion Animal Medicine, School of Veterinary Medicine, Aristotle University of Thessaloniki, Greece
    J Vet Intern Med 20:228-33. 2006
    ..Mesangioproliferative and tubulointerstitial nephritis were detected even in group A and CA dogs...
  14. ncbi Effective duration of antimicrobial therapy for the treatment of acute lobar nephronia
    Chi Hui Cheng
    Division of Pediatric Nephrology, Department of Pediatrics, Chang Gung Children s Hospital, Taoyuan, Taiwan
    Pediatrics 117:e84-9. 2006
    ..The goal of this prospective study was to compare the treatment efficacy for pediatric patients who had ALN with a 3- vs 2-week intravenous plus oral antimicrobial-therapy regimen...
  15. pmc Inhibition of macrophage nuclear factor-kappaB leads to a dominant anti-inflammatory phenotype that attenuates glomerular inflammation in vivo
    Heather M Wilson
    Department of Medicine and Therapeutics, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, Scotland, AB25 2ZD, UK
    Am J Pathol 167:27-37. 2005
    ..nitric oxide synthase and MHC class II expression when activated naturally in glomeruli of rats with nephrotoxic nephritis. Furthermore, although they only comprised 15% of glomerular macrophages, their presence significantly reduced ..
  16. doi Henoch-Schönlein purpura nephritis in children: risk factors, prevention and treatment
    Radovan Bogdanovic
    The Institute of Mother and Child Healthcare of Serbia Dr Vukan Cupic, Belgrade, Serbia
    Acta Paediatr 98:1882-9. 2009
    To identify risk factors for a child with Henoch-Schönlein purpura (HSP) either to develop nephritis (HSPN) or to contract progressive course and to obtain the currently available evidence on the efficacy of treatment options in both ..
  17. ncbi Mechanisms underlying the ameliorative property of lisinopril in progressive mesangioproliferative nephritis
    Toshihiro Shinosaki
    Shionogi Discovery Research Laboratories, Shionogi and Co, Toyonaka City, Osaka, Japan
    Nephron 91:719-29. 2002
    ..These results indicated that proteinuria in Thy-1.1 antibody-induced chronic nephritis is associated with a decrease in anionic charge sites on GBM, and that the antiproteinuric effect of lisinopril ..
  18. doi A case of IgG4-related sclerosing disease with retroperitoneal fibrosis, autoimmune pancreatitis and bilateral focal nephritis
    Wouter Van Moerkercke
    Department of Gastroenterology and Hepatology, University Hospitals Leuven, Herestraat, Belgium
    Pancreas 38:825-32. 2009
    ..IgG4-related sclerosing disease with involvement of the pancreas, retroperitoneal fibrosis, and bilateral focal nephritis. To our knowledge, this is the first report on these 3 clinical entities occurring in the same patient...
  19. ncbi Comparison of extended virulence genotypes for bacteria isolated from pediatric patients with urosepsis, acute pyelonephritis, and acute lobar nephronia
    Chi Hui Cheng
    Department of Pediatrics, Division of Pediatric Nephrology, Chang Gung Children s Hospital, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Pediatr Infect Dis J 29:736-40. 2010
    ..This study was conducted to explore and differentiate bacterial virulence factors associated with urosepsis and 2 other severe parenchymal infections, acute pyelonephritis (APN) and acute lobar nephronia (ALN), in pediatric patients...
  20. pmc The effects of PTK787/ZK222584, an inhibitor of VEGFR and PDGFRβ pathways, on intussusceptive angiogenesis and glomerular recovery from Thy1.1 nephritis
    Monika Wnuk
    Department of Nephrology and Hypertension, Inselspital, University of Bern Medical School, Bern, Switzerland
    Am J Pathol 178:1899-912. 2011
    ..Glomerular healing by intussusception was examined in a particular setting of Thy1.1 nephritis, where the lysis of mesangial cells results in an initial collapse and successive rebuilding of glomerular ..
  21. pmc Serial non-invasive monitoring of renal disease following immune-mediated injury using near-infrared optical imaging
    Yong Du
    Internal Medicine Rheumatology, University of Texas, Southwestern Medical Center, Dallas, Texas, USA
    PLoS ONE 7:e43941. 2012
    ..The LI-COR IRDye® 800CW RGD optical probe (RGD probe) is a NIR fluorophore, that can target integrin alpha v beta 3 (α(v)β(3)) in tissues...
  22. ncbi Comparison of urovirulence factors and genotypes for bacteria causing acute lobar nephronia and acute pyelonephritis
    Chi Hui Cheng
    Division of Pediatric Nephrology, Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Pediatr Infect Dis J 26:228-32. 2007
    ..This prospective study was conducted to elucidate and distinguish the bacterial virulence factors associated with ALN and acute pyelonephritis (APN) in pediatric patients...
  23. doi Clinical outcomes, when matched at presentation, do not vary between adult-onset Henöch-Schönlein purpura nephritis and IgA nephropathy
    Hyung Jung Oh
    Divison of Nephrology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    Kidney Int 82:1304-12. 2012
    Henöch-Schönlein purpura nephritis (HSPN) is considered a systemic form of immunoglobulin A nephropathy (IgAN)...
  24. ncbi Vasodilator-stimulated phosphoprotein-deficient mice demonstrate increased platelet activation but improved renal endothelial preservation and regeneration in passive nephrotoxic nephritis
    Bernd Hohenstein
    Division of Nephrology, University Erlangen Nuremberg, Loschgestrasse 8, Erlangen 91054, Germany
    J Am Soc Nephrol 16:986-96. 2005
    ..Passive nephrotoxic nephritis was induced in 28 VASP -/- and 28 wt mice; kidneys were harvested; and tissues were analyzed by morphometric, ..
  25. doi Sublytic C5b-9 complexes induce proliferative changes of glomerular mesangial cells in rat Thy-1 nephritis through TRAF6-mediated PI3K-dependent Akt1 activation
    Wen Qiu
    Department of Immunology and Lab of Immunopathology, Nanjing Medical University, People s Republic of China
    J Pathol 226:619-32. 2012
    The proliferation of glomerular mesangial cells (GMCs) and secretion of extracellular matrix (ECM) in rat Thy-1 nephritis (Thy-1N), resembling human mesangioproliferative glomerulonephritis (MsPGN), have been studied for many years, but ..
  26. doi The pathogenesis and treatment of pediatric Henoch-Schönlein purpura nephritis
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga oka, Fukushima, Fukushima 960 1295, Japan
    Clin Exp Nephrol 15:648-57. 2011
    ..Thus, it is important to clarify the onset mechanism of Henoch-Schönlein purpura nephritis (HSPN) and to identify the most appropriate treatment. We herein review the pathogenesis and treatment of HSPN...
  27. ncbi Characterization of an avian infectious bronchitis virus isolated in China from chickens with nephritis
    J Y Zhou
    Institute of Preventive Veterinary Medicine, Zhejiang University, 268 Kaixuan Road, Hangzhou 310029, China
    J Vet Med B Infect Dis Vet Public Health 51:147-52. 2004
    ..These results indicated that IBV isolate SC021202 was a new variant IBV isolate and responsible for field outbreak of nephritis.
  28. pmc Three genes for lupus nephritis in NZB x NZW mice
    J G Knight
    J Exp Med 147:1653-60. 1978
    The occurrence of early severe lupus nephritis in (NZB x NZW)F1 mice must depend on the action of at least two dominant or codominant genes (at least one gene from each parent) as neither of the inbred parental strains shows the disorder...
  29. ncbi Nephritis-associated streptococcal antigens: where are we now?
    Bernardo Rodriguez-Iturbe
    J Am Soc Nephrol 15:1961-2. 2004
  30. ncbi Excreted urinary mediators in an animal model of experimental immune nephritis with potential pathogenic significance
    Tianfu Wu
    University of Texas Southwestern Medical School at Dallas, New York 75390, USA
    Arthritis Rheum 56:949-59. 2007
    Currently, proteinuria is viewed as the earliest indicator of renal disease in immune-mediated nephritis. The objective of this study was to determine whether additional mediators may be excreted in the urine during immune-mediated ..
  31. ncbi Rapamycin attenuates the severity of established nephritis in lupus-prone NZB/W F1 mice
    Sing Leung Lui
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, People s Republic of China
    Nephrol Dial Transplant 23:2768-76. 2008
    ..The aim of this study was to determine the effect of rapamycin on the severity of established nephritis in lupus-prone New Zealand Black/White F(1) (NZB/W F(1)) mice.
  32. ncbi Use of urine samples from healthy humans, nephritis patients or other animals as an alternative to foetal calf serum in the culture of Leishmania (L.) donovani in vitro
    S M Shamsuzzaman
    Department of Parasitology, Faculty of Medicine, Kochi Medical School, Japan
    Ann Trop Med Parasitol 93:613-20. 1999
    ..The urine samples used were collected from healthy human donors, patients with nephrotic syndrome, diabetic nephritis (DN) or diabetes mellitus, a dog and a cow...
  33. pmc Tim3 is upregulated and protective in nephrotoxic serum nephritis
    Andrea Schroll
    Department of Internal Medicine I, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Am J Pathol 176:1716-24. 2010
    ..diseases, we investigated whether Tim3 is involved in the pathogenesis of the T(H)-1-dependent nephrotoxic nephritis (NTS)...
  34. pmc Antibodies to endothelial cells in systemic lupus erythematosus: a potential marker for nephritis and vasculitis
    D P D'Cruz
    Lupus Arthritis Research Unit, Rayne Institute, Department of Immunology, St Thomas Hospital, London, England
    Clin Exp Immunol 85:254-61. 1991
    ..obtained at the time of renal biopsy in 46 out of 57 patients (81%) with systemic lupus erythematosus (SLE) and nephritis (mean binding index (BI) = 84% +/- 52...
  35. ncbi The medical response to trench nephritis in World War One
    R L Atenstaedt
    National Public Health Service for Wales and Institute of Medical and Social Care Research IMSCaR, University of Wales, Bangor, UK
    Kidney Int 70:635-40. 2006
    ..effort that went into responding to the new diseases, which appeared during the First World War, such as trench nephritis. This condition arose among soldiers in spring 1915, characterized by breathlessness, swelling of the face or ..
  36. doi A new fluorescent imaging of renal inflammation with RCP
    Kentaro Nakamura
    Life Science Research Laboratories, FUJIFILM Corporation, 577 Ushijima, Kaisei Machi, Ashigarakami gun, Kanagawa 258 8577, Japan
    J Control Release 148:351-8. 2010
    ..After intravenous administration of R-Gel labeled by Cy7 of a fluorescent dye to three animal models of nephritis mousse, interstitial nephritis (by using UUO model mice), glomerulonephritis (HIGA mice), and ischemia-..
  37. ncbi Granulomatous nephritis in psittacines associated with parasitism by the trematode Paratanaisia spp
    Marcela M Luppi
    Fundação Zoo Botânica de Belo Horizonte, Av Otacílio Negrão de Lima, 8000 31365 450 Belo Horizonte, MG, Brazil
    Vet Parasitol 146:363-6. 2007
    ..infiltrate with some epithelioid macrophages, and a few heterophils, characterizing a granulomatous nephritis. Adult worms and eggs were observed within dilated tubules and in the renal pelvis...
  38. doi Economic outcomes in patients diagnosed with systemic lupus erythematosus with versus without nephritis: results from an analysis of data from a US claims database
    Elise M Pelletier
    Health Economics and Outcomes Research, IMS Health Inc, Watertown, Massachusetts 02472, USA
    Clin Ther 31:2653-64. 2009
    Based on a literature search, there are limited data on the economic burden of systemic lupus erythematosus (SLE), particularly in patients with lupus nephritis.
  39. doi Oral administration of different forms of a tolerogenic peptide to define the preparations and doses that delay anti-DNA antibody production and nephritis and prolong survival in SLE-prone mice
    B J Skaggs
    University of California, Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA
    Lupus 20:912-20. 2011
    ..Induction of oral tolerance using modified pCons peptides could lead to a novel targeted therapy for human SLE...
  40. ncbi Glomerular monocyte-macrophage features in ANCA-positive renal vasculitis and cryoglobulinemic nephritis
    M P Rastaldi
    Renal Immunopathology Center, San Carlo Borromeo Hospital, Milan, Italy
    J Am Soc Nephrol 11:2036-43. 2000
    ..Moreover, acute activation and cytokine production seem to be present in a greater number of macrophages in ANCA + RV, giving this disease a stronger severity that could be taken into account for therapeutic strategies...
  41. ncbi Resolution of Henoch-Schönlein purpura nephritis after acquired IgA deficiency
    Mototsugu Tanaka
    Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    Pediatr Nephrol 25:2355-8. 2010
    We report a case of Henoch-Schönlein purpura nephritis (HSPN) with acquired IgA deficiency due to parvovirus B19 infection...
  42. ncbi Ras antagonist farnesylthiosalicylic acid (FTS) reduces glomerular cellular proliferation and macrophage number in rat thy-1 nephritis
    Helen C Clarke
    Renal Medicine, GKT School of Medicine, King s College, London, England
    J Am Soc Nephrol 14:848-54. 2003
    ..This article reports the effects of Ras antagonist farnesylthiosalicylic acid (FTS) in rat thy-1 nephritis, a model in which cytokine-driven glomerular cell proliferation and invasion is likely to involve Ras signaling ..
  43. ncbi Effects of all-trans retinoic acid on renin-angiotensin system in rats with experimental nephritis
    C Dechow
    Division of Nephrology, University of Heidelberg, D-69115, Germany
    Am J Physiol Renal Physiol 281:F909-19. 2001
    ..1 nephritis (Wagner J, Dechow C, Morath C, Lehrke I, Amann K, Floege J, and Ritz E. J Am Soc Nephrol 11: 1479-1489, 2000)...
  44. doi Interleukin-6 promoter polymorphism -174 G/C is associated with nephritis in Portuguese Caucasian systemic lupus erythematosus patients
    Maria Jose Santos
    Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
    Clin Rheumatol 30:409-13. 2011
    ..The IL-6 gene promoter polymorphism at position -174 does not contribute to SLE susceptibility in Portuguese Caucasian patients but may predispose to specific manifestations of the disease...
  45. doi Recovery of BK virus large T-antigen-specific cellular immune response correlates with resolution of bk virus nephritis
    Simon E Prosser
    1 Division of Nephrology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Transplantation 85:185-92. 2008
    ..BKV infection progresses to BKV nephritis (BKVN) in approximately 8% of transplants and in half of these cases the graft is lost.
  46. doi Henoch-Schönlein purpura nephritis with nephrotic state in children: predictors of poor outcomes
    Hitoshi Wakaki
    Department of Pediatrics, Yokohama Municipal Citizen s Hospital, 56 Okazawa cho, Hodogaya ku, Yokohama, 240 0062, Japan
    Pediatr Nephrol 26:921-5. 2011
    b>Nephritis develops in 18-81% of Henoch-Schönlein purpura patients, and the long-term outcomes of this nephritis show great variation. A nephrotic state at disease onset has been proposed as a predictor of poor renal outcomes...
  47. ncbi Interleukin 8 gene polymorphism is associated with increased risk of nephritis in cutaneous vasculitis
    Mahsa M Amoli
    ARC Epidemiology Unit, Manchester University Medical School, Manchester, United Kingdom
    J Rheumatol 29:2367-70. 2002
    ....
  48. ncbi Effect of early corticosteroid therapy on development of Henoch-Schönlein nephritis
    Umut S Bayrakci
    Department of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    J Nephrol 20:406-9. 2007
    ..Findings of previous reports addressing the preventive effect of corticosteroid treatment in HSP nephritis have been inconsistent...
  49. ncbi Henoch-Schönlein nephritis: a nationwide study
    O Soylemezoglu
    Gazi University, Department of Pediatric Nephrology, Ankara, Turkey
    Nephron Clin Pract 112:c199-204. 2009
    The aim of this retrospective study was to evaluate the presentation, clinical and pathological manifestations and outcome of the Henoch-Schönlein purpura (HSP) nephritis in children.
  50. ncbi Outcome of Henoch-Schönlein purpura nephritis treated with long-term immunosuppression
    Mohan Shenoy
    Department of Paediatric Nephrology, Royal Manchester Children s Hospital, Manchester M27 4HA, UK
    Pediatr Nephrol 22:1717-22. 2007
    This retrospective study investigated the outcome of 27 children (19 male) with Henoch-Schönlein purpura nephritis (HSN) of International Study of Kidney Disease in Children (ISKDC) grade 3b or higher treated with long-term ..
  51. doi Anti-programmed cell death 1 antibody reduces CD4+PD-1+ T cells and relieves the lupus-like nephritis of NZB/W F1 mice
    Shimpei Kasagi
    Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650 0017, Japan
    J Immunol 184:2337-47. 2010
    ..In this study, we used NZB/W F1 mice, a model of lupus-like nephritis, to examine the function of PD-1 and its ligands...
  52. ncbi Predictive factors for nephritis, relapse, and significant proteinuria in childhood Henoch-Schönlein purpura
    J I Shin
    Department of Paediatrics, The Institute of Kidney Disease, Yonsei University, College of Medicine, Seoul, Korea
    Scand J Rheumatol 35:56-60. 2006
    To identify predictive factors for nephritis, relapse, and significant proteinuria in childhood Henoch-Schönlein purpura (HSP).
  53. ncbi Coordinate gene expression of the alpha3, alpha4, and alpha5 chains of collagen type IV. Evidence from a canine model of X-linked nephritis with a COL4A5 gene mutation
    P S Thorner
    Department of Pathology, The Hospital for Sick Children and the University of Toronto, Toronto, Ontario M5G 1X8, Canada
    J Biol Chem 271:13821-8. 1996
    Canine X-linked hereditary nephritis is an animal model for human X-linked hereditary nephritis with a premature stop codon in the alpha5(IV) gene of collagen type IV...
  54. ncbi Urinary excretion of interleukin-6 correlates with proteinuria in acute Puumala hantavirus-induced nephritis
    Satu Makela
    Medical School, University of Tampere and Tampere University Hospital, Tampere, Finland
    Am J Kidney Dis 43:809-16. 2004
    ..Cytokines are thought to have an important role in the pathogenesis of NE. The aim of this study is to evaluate whether cytokines contribute to renal involvement in NE...
  55. ncbi Analysis and classification of B-cell infiltrates in lupus and ANCA-associated nephritis
    Oliver M Steinmetz
    III Medizinische Klinik, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Kidney Int 74:448-57. 2008
    ..Therefore we characterized intrarenal lymphoid clusters of 32 patients diagnosed with lupus nephritis and 16 with ANCA associated nephritis...
  56. pmc A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus
    O T Chan
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Exp Med 189:1639-48. 1999
    ..These mice developed nephritis, characterized by cellular infiltration within the kidney, indicating that B cells themselves, without soluble ..
  57. ncbi Clinical outcome in children with Henoch-Schönlein nephritis
    Sevgi Mir
    Faculty of Medicine, Department of Pediatric Nephrology, Ege University, Izmir, Turkey
    Pediatr Nephrol 22:64-70. 2007
    ..features of the children with HSP and the prognoses of short- and long-term outcome of patients diagnosed as HSP nephritis (HSN)...
  58. ncbi 15-Deoxyspergualin and cyclophosphamide, but not mycophenolate mofetil, prolong survival and attenuate renal disease in a murine model of ANCA-associated crescentic nephritis
    Rainer Birck
    Fifth Department of Medicine, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, D 68135 Mannheim, Germany
    Nephrol Dial Transplant 21:58-63. 2006
    Here we compare the efficacy of cyclophosphamide (CYC) for treatment of crescentic nephritis (CGN) with the newer immunosuppressants 15-deoxyspergualin (DSG) and mycophenolate mofetil (MMF) in SCG/Kj mice, an inbred mouse strain that ..
  59. doi Human heme oxygenase-1 deficiency presenting with hemolysis, nephritis, and asplenia
    Nita Radhakrishnan
    Department of Pediatrics, Pediatric Hematology Oncology and BMT Unit, Sir Ganga Ram Hospital, New Delhi, India
    J Pediatr Hematol Oncol 33:74-8. 2011
    ..report another case of human HO-1 deficiency in a young girl with congenital asplenia, who presented with severe hemolysis, inflammation, nephritis, which was refractory to therapy with corticosteroids, cyclophosphamide, and rituximab.
  60. ncbi Gene expression profile and overexpression of apoptosis-related genes (NGFI-B and Gadd 45 gamma) in early phase of Thy-1 nephritis model
    Jing Hua Xu
    Department of Immunology, Nanjing Medical University, Nanjing Hanzhong Road 140, Jiangsu Province, 210029, People s Republic of China
    Cell Tissue Res 326:159-68. 2006
    Mesangioproliferative glomerulonephritis (MPGN) is a disease of high incidence in humans. Rat Thy-1 nephritis (Thy-1 N), namely, anti-thymocyte serum (ATS)-induced nephritis, is considered to be an animal model for studying MPGN...
  61. ncbi Efficacy of methylprednisolone and urokinase pulse therapy for severe Henoch-Schönlein nephritis
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
    Pediatrics 111:785-9. 2003
    To evaluate the efficacy of methylprednisolone and urokinase pulse therapy (MUPT) for severe Henoch-Schönlein nephritis, we examined the clinical manifestation and prognosis of patients with MUPT on long-term observation.
  62. doi Apoptosis of glomerular mesangial cells induced by sublytic C5b-9 complexes in rats with Thy-1 nephritis is dependent on Gadd45 gamma upregulation
    Wen Qiu
    Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, Jiangsu, PR China
    Eur J Immunol 39:3251-66. 2009
    ..cell apoptosis, but the mechanism of sublytic C5b-9-mediated glomerular mesangial cell (GMC) apoptosis in Thy-1 nephritis (Thy-1N) remains largely unclear...
  63. pmc BK virus nephritis after renal transplantation
    Aaron Dall
    Division of Nephrology, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    Clin J Am Soc Nephrol 3:S68-75. 2008
    BK virus nephritis is an increasing problem and is posing a threat to improving renal transplant graft survival. The pathogenesis of this condition remains to be investigated...
  64. pmc High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy
    Yoko Oyama
    Department of Laboratory and Vascular Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Lab Invest 90:853-66. 2010
    Granulomatous nephritis can be triggered by diverse factors and results in kidney failure. However, despite accumulating data about granulomatous inflammation, pathogenetic mechanisms in nephritis remain unclear...
  65. ncbi Plasmapheresis as the sole therapy for rapidly progressive Henoch-Schönlein purpura nephritis in children
    M Hattori
    Department of Pediatric Nephrology, Tokyo Women s Medical University, School of Medicine, Japan
    Am J Kidney Dis 33:427-33. 1999
    To clarify the therapeutic role of plasmapheresis (PP) for patients with Henoch-Schönlein purpura (HSP) nephritis, the clinical courses of nine children with a rapidly progressive type of HSP nephritis, who were treated with PP as the ..
  66. ncbi Successful treatment of progressive Henoch-Schönlein purpura nephritis with tonsillectomy and steroid pulse therapy
    Hitoshi Sugiyama
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry
    Intern Med 44:611-5. 2005
    ..We report here an adult patient with HSP nephritis (HSPN) accompanied by persistent proteinuria and progressive renal dysfunction despite conventional therapy...
  67. ncbi BK virus-specific antibodies and BKV DNA in renal transplant recipients with BKV nephritis
    Sundaram Hariharan
    The Division of Nephrology, Medical College of Wisconsin, Milwaukee, WI, USA
    Am J Transplant 5:2719-24. 2005
    We evaluated twenty renal transplant subjects at various stages of BKV nephritis (BKVN) for BKV-specific IgG and IgM antibodies using ELISA technique and BKV-DNA using PCR...
  68. ncbi Predictors of outcome in Henoch-Schönlein nephritis in children and adults
    Rosanna Coppo
    Nephrology, Dialysis and Transplantation Unit, Regina Margherita Hospital, Turin, Italy
    Am J Kidney Dis 47:993-1003. 2006
    Factors predictive of renal outcome were investigated in 219 cases of biopsy-proven Henoch-Schönlein purpura nephritis (HSPN); 83 children and 136 adults enrolled in a national study were followed up for up to 27 years (median, 4...
  69. ncbi Possible pathologenic role of interleukin-5 and eosino cationic protein in Henoch-Schönlein purpura nephritis
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan
    Pediatr Int 47:512-7. 2005
    The mechanism for the onset of Henoch-Schönlein purpura nephritis is unknown...
  70. ncbi Streptococcal origin of a case of Henoch-Schoenlein purpura nephritis
    Y Kikuchi
    Second Department of Internal Medicine, National Defense Medical College, Namiki, Tokorozawa, Saitama, Japan
    Clin Nephrol 65:124-8. 2006
    ..occurring 2 weeks after acute tonsillitis, and admitted to our hospital with suspected Henoch-Schönlein purpura nephritis (HSPN). He had increased anti-streptolysin O (ASO) titer and hypocomplementemia...
  71. pmc SLEN2 (2q34-35) and SLEN1 (10q22.3) replication in systemic lupus erythematosus stratified by nephritis
    Ana I Quintero-del-Rio
    Am J Hum Genet 75:346-8. 2004
  72. ncbi Prevention and reversal of nephritis in MRL/lpr mice with a single injection of C-reactive protein
    Wilfredo Rodriguez
    University of New Mexico School of Medicine, Albuquerque, NM 87108, USA
    Arthritis Rheum 54:325-35. 2006
    ..These mice develop high-titer anti-DNA antibodies and immune complex-mediated nephritis and exhibit progressive lymphadenopathy...
  73. pmc Pathology and protection in nephrotoxic nephritis is determined by selective engagement of specific Fc receptors
    Yoshikatsu Kaneko
    Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 203:789-97. 2006
    ..These results establish the significance of specific IgG subclasses and their cognate FcgammaRs in renal disease...
  74. ncbi Development of nephritis but not sialadenitis in autoimmune-prone BAFF transgenic mice lacking marginal zone B cells
    Carrie A Fletcher
    Immunology and Inflammation Research Program, The Garvan Institute of Medical Research, Sydney, Australia
    Eur J Immunol 36:2504-14. 2006
    ..BAFF transgenic (Tg) mice develop autoimmune disorders characterized by autoantibody production, which leads to nephritis and salivary gland destruction (sialadenitis), features reminiscent of systemic lupus erythematosus and Sjögren'..
  75. ncbi Henoch-Schönlein purpura nephritis with nephrotic-range proteinuria: histological regression possibly associated with cyclosporin A and steroid treatment
    J I Shin
    Department of Paediatrics, The Institute of Kidney Disease, Yonsei University College of Medicine, Severance Hospital, Seoul, Korea
    Scand J Rheumatol 34:392-5. 2005
    To clarify the therapeutic role of cyclosporin A (CyA) for patients with Henoch-Schönlein purpura nephritis (HSPN) showing nephrotic-range proteinuria.
  76. ncbi Coincident scrapie infection and nephritis lead to urinary prion excretion
    Harald Seeger
    Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Science 310:324-6. 2005
    ..Urinary proteins from scrapie-infected mice with lymphocytic nephritis induced scrapie upon inoculation into noninfected indicator mice...
  77. ncbi Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritis
    Eugene T Grygielko
    Urogenital Biology, GlaxoSmithKline, King of Prussia, PA 19406, USA
    J Pharmacol Exp Ther 313:943-51. 2005
    ..the role of TGF-beta1 in the acute puromycin aminonucleoside (PAN) rat model of renal disease, a model of nephritis-induced renal fibrosis...
  78. ncbi Polyomavirus (BK) in pediatric renal transplants: evaluation of viremic patients with and without BK associated nephritis
    Leonard C Hymes
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Pediatr Transplant 10:920-2. 2006
    ..complication in renal transplantation, which may lead to renal dysfunction and graft loss caused by BK nephritis (BKN). We report the management and outcome of 20 children who developed BK viremia...
  79. pmc CD134 expression on CD4+ T cells is associated with nephritis and disease activity in patients with systemic lupus erythematosus
    S Patschan
    Department of Nephrology, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Clin Exp Immunol 145:235-42. 2006
    ..Eleven patients had biopsy-proven lupus nephritis while 17 patients had no clinical evidence of lupus nephritis...
  80. ncbi IgA nephropathy and Henoch-Schoenlein purpura nephritis: aberrant glycosylation of IgA1, formation of IgA1-containing immune complexes, and activation of mesangial cells
    Jan Novak
    University of Alabama at Birmingham, Department of Microbiology, Birmingham, AL 35294, USA
    Contrib Nephrol 157:134-8. 2007
    ..The circulating IgA1 of patients with Henoch-Schoenlein purpura nephritis (HSPN) has a similar defect...
  81. ncbi Risk factors for BK polyomavirus nephritis in renal allograft recipients
    Paulo N Rocha
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Clin Transplant 18:456-62. 2004
    ..AR) and/or the intense immunosuppression used for their treatment have been proposed as risk factors for BK nephritis (BKN; BK refers to the initials of the first patient from whom this polyomavirus was isolated)...
  82. ncbi Clinical and pathological features of children with Henoch-Schoenlein purpura nephritis: risk factors associated with poor prognosis
    Y Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
    Clin Nephrol 60:153-60. 2003
    To clarify the risk factors related to prognosis in patients with Henoch-Schoenlein purpura nephritis (HSPN), we investigated the cases with HSPN on long-term observation.
  83. ncbi The targets of nephritogenic antibodies in systemic autoimmune disorders
    P Migliorini
    Clinical Immunology Unit, Department of Internal Medicine, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    Autoimmun Rev 1:168-73. 2002
    ..Alpha-actinin, an actin-binding protein localized in glomerular podocytes, is the major target of nephritogenic anti-DNA antibodies. Alpha-enolase, a glycolytic enzyme, is a target of nephritogenic anti-DNA and non-anti-DNA antibodies...
  84. ncbi Nephritis-associated plasmin receptor and acute poststreptococcal glomerulonephritis: characterization of the antigen and associated immune response
    Nobuyuki Yoshizawa
    Department of Public Health, National Defense Medical College, Saitama, Japan
    J Am Soc Nephrol 15:1785-93. 2004
    The role of nephritis-associated antigen as a virulence factor for acute poststreptococcal glomerulonephritis (APSGN) remains to be fully clarified...
  85. doi Renal expression of alpha-smooth muscle actin and c-Met in children with Henoch-Schönlein purpura nephritis
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga oka, Fukushima City, Fukushima 960 1295, Japan
    Pediatr Nephrol 23:913-9. 2008
    ..whether alpha-SMA and HGF are associated with the progression of renal injury in Henoch-Schönlein purpura nephritis (HSPN), we evaluated the renal expression of alpha-SMA and c-Met in HSPN patients...
  86. ncbi Henoch-Schönlein purpura nephritis
    Fernando C Fervenza
    Division of Nephrology, Mayo Clinic, Rochester, MN 55905, USA
    Int J Dermatol 42:170-7. 2003
  87. pmc Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis
    Steven D Crowley
    Department of Medicine, Division of Nephrology, Duke University Medical Center, and Durham VA Medical Center, Durham, North Carolina 27705, USA
    J Clin Invest 119:943-53. 2009
    ..Since AT1A-deficient lpr mice had low blood pressure, these findings suggest that activation of type 1 angiotensin receptors in the glomerulus is sufficient to accelerate renal injury and inflammation in the absence of hypertension...
  88. doi Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus
    Carlos Geraldo Moura
    Hospital Santo Antonio, Escola Bahiana de Medicina e Saude Publica, Salvador, Brazil
    J Clin Lab Anal 23:19-23. 2009
    Anti-C1q antibodies have been described in systemic lupus erythematosus (SLE) as well as in other connective tissue diseases. They have been considered as a marker for disease activity and presence of nephritis.
  89. pmc Genome sequence of a Lancefield group C Streptococcus zooepidemicus strain causing epidemic nephritis: new information about an old disease
    Stephen B Beres
    Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, Texas, USA
    PLoS ONE 3:e3026. 2008
    ..zooepidemicus strain MGCS10565, a group C organism that caused a very large and unusually severe epidemic of nephritis in Brazil. The genome is a circular chromosome of 2,024,171 bp...
  90. ncbi Noninvasive diagnosis of BK virus nephritis by measurement of messenger RNA for BK virus VP1 in urine
    Ruchuang Ding
    Division of Nephrology, Departments of Medicine and Transplantation Medicine, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10021, USA
    Transplantation 74:987-94. 2002
    Polyoma virus type BK (BKV) nephritis has emerged as an important cause of renal allograft dysfunction and graft failure. Its diagnosis is contingent on the invasive procedure of allograft biopsy...
  91. ncbi Treatment-based literature of Henoch-Schönlein purpura nephritis in childhood
    Marco Zaffanello
    Department of Mother Child and Biology Genetics, University of Verona, 37134 Verona, Italy
    Pediatr Nephrol 24:1901-11. 2009
    ..of identifying an improved therapeutic protocol for use in the treatment of childhood Henoch-Schönlein purpura nephritis, primarily due to the unpredictable success shown to date in improving long-term renal outcome...
  92. ncbi Association of angiotensin-converting enzyme polymorphisms with systemic lupus erythematosus and nephritis: analysis of 644 SLE families
    A Parsa
    Division of Nephrology, Department of Medicine, University of California, San Francisco, CA, USA
    Genes Immun 3:S42-6. 2002
    Angiotensin II is a strong candidate for the perpetuation of autoimmunity, nephritis and visceral damage in systemic lupus erythematosus (SLE)...
  93. ncbi Serum protein oxidation and apolipoprotein CIII levels in people with systemic lupus erythematosus with and without nephritis
    Philip E Morgan
    Free Radical Group, The Heart Research Institute, Camperdown, Sydeny, Australia
    Free Radic Res 41:1301-12. 2007
    ..This study compares serum protein oxidation levels in SLE patients without and with renal involvement (lupus nephritis); the latter have a significantly poorer prognosis...
  94. ncbi Acute focal bacterial nephritis in 25 children
    Tanja Seidel
    Universitaetsklinikum Münster, University Children s Hospital, Munster, Germany
    Pediatr Nephrol 22:1897-901. 2007
    Acute focal bacterial nephritis (AFBN), formerly known as lobar nephronia, is a rare form of interstitial bacterial nephritis. Most often described in adults with diabetes, there is only limited knowledge of AFBN in children...
  95. ncbi Prevention of mercuric chloride-induced nephritis in the brown Norway rat by treatment with antibodies against the alpha 4 integrin
    A Molina
    Department of Pathology, , Madrid, Spain
    J Immunol 153:2313-20. 1994
    HgCl2 induces the synthesis of anti-GBM Abs with the development of glomerular and interstitial nephritis, as well as proteinuria, in the Brown Norway rat...
  96. ncbi Chemokine receptor CXCR3 mediates T cell recruitment and tissue injury in nephrotoxic nephritis in mice
    Ulf Panzer
    Medizinische Klinik III, Zentrum fur Innere Medizin, University of Hamburg, Martinistrasse 52, Hamburg, Germany
    J Am Soc Nephrol 18:2071-84. 2007
    ..testing whether CXCR3 plays a role in renal inflammation, CXCR3-deficient mice were generated and nephrotoxic nephritis was induced in C57BL/6 CXCR3(-/-) and C57BL/6 wild-type mice...
  97. ncbi Complement activation through the lectin pathway in patients with Henoch-Schönlein purpura nephritis
    M Endo
    Second Department of Internal Medicine, Nihon University School of Medicine, Tokyo
    Am J Kidney Dis 35:401-7. 2000
    Henoch-Schönlein purpura nephritis (HSPN) is considered a form of systemic vasculitis of the small blood vessels with immune pathogenesis...
  98. ncbi Functional relevance of activated beta1 integrins in mercury-induced nephritis
    E Escudero
    Department of Pathology, , , Madrid, Spain
    J Am Soc Nephrol 11:1075-84. 2000
    ..synthesis and glomerular deposits of anti-glomerular basement membrane antibodies, proteinuria, and interstitial nephritis. Using the mercury model of nephritis, it was found that the expression of HUTS-21 epitope is induced in vivo in ..
  99. ncbi Epidemic nephritis in Nova Serrana, Brazil
    S Balter
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Lancet 355:1776-80. 2000
    Outbreaks of nephritis have been rare since the 1970s. From December, 1997, to July, 1998, 253 cases of acute nephritis were identified in Nova Serrana, Brazil. Seven patients required dialysis, and three patients died...
  100. ncbi Nitric oxide inhibition enhances platelet aggregation in experimental anti-Thy-1 nephritis
    H van Goor
    Department of Pathology and Laboratory Medicine, University Hospital Groningen, Groningen, The Netherlands
    Nitric Oxide 5:525-33. 2001
    ..Urinary protein excretion was significantly elevated in Thy-1 nephritis at 3 and 7 days...
  101. ncbi Henoch-Schönlein purpura nephritis: course of disease and efficacy of cyclophosphamide
    Penina Tarshish
    Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Pediatr Nephrol 19:51-6. 2004
    b>Nephritis in Henoch-Schönlein purpura (HSP) is the primary cause of morbidity and mortality. Although many therapeutic regimens have been reported to be effective, no therapy has been shown in a controlled trial to be beneficial...

Research Grants79

  1. INTERACTIONS OF PEPTIDES W/ CLASS II MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULES
    Hugh McDevitt; Fiscal Year: 2002
    ..to test the hypothesis that the MHC linked genetic factor contributed by the NZW strain to the NZB x NZW lupus nephritis model is the I-Au molecule. 2) Expression of phosphoinositol (P.I...
  2. INTERACTIONS OF PEPTIDES W/ CLASS II MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULES
    Hugh McDevitt; Fiscal Year: 2000
    ..to test the hypothesis that the MHC linked genetic factor contributed by the NZW strain to the NZB x NZW lupus nephritis model is the I-Au molecule. 2) Expression of phosphoinositol (P.I...
  3. INTERACTIONS OF PEPTIDES W/ CLASS II MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULES
    Hugh McDevitt; Fiscal Year: 2001
    ..to test the hypothesis that the MHC linked genetic factor contributed by the NZW strain to the NZB x NZW lupus nephritis model is the I-Au molecule. 2) Expression of phosphoinositol (P.I...
  4. MECHANISMS OF STREPTOCOCCAL/HOST INTERACTION
    JOHN ZABRISKIE; Fiscal Year: 2001
    ..All nephritogenic strains produce a protein called nephritis plasmin binding protein (NPBP) which was isolated, sequenced and found to be identical with streptococcal ..
  5. MECHANISMS OF STREPTOCOCCAL/HOST INTERACTION
    JOHN ZABRISKIE; Fiscal Year: 2000
    ..All nephritogenic strains produce a protein called nephritis plasmin binding protein (NPBP) which was isolated, sequenced and found to be identical with streptococcal ..
  6. MECHANISMS OF STREPTOCOCCAL/HOST INTERACTION
    JOHN ZABRISKIE; Fiscal Year: 2002
    ..All nephritogenic strains produce a protein called nephritis plasmin binding protein (NPBP) which was isolated, sequenced and found to be identical with streptococcal ..
  7. MECHANISMS OF STREPTOCOCCAL/HOST INTERACTION
    JOHN ZABRISKIE; Fiscal Year: 1999
    ..All nephritogenic strains produce a protein called nephritis plasmin binding protein (NPBP) which was isolated, sequenced and found to be identical with streptococcal ..
  8. Clinical Component
    BRIAN KOTZIN; Fiscal Year: 2003
    ..ACE includes groups doing clinical investigation on type 1 diabetes, systemic lupus erythematosus and lupus nephritis, rheumatoid arthritis, systemic sclerosis, multiple sclerosis, autoimmune pulmonary diseases including ..
  9. AUTOIMMUNITY CENTER OF EXCELLENCE
    David Wofsy; Fiscal Year: 2009
    ..a phase Ib/lla trial of anti-CD20 plus cyclophosphamide (IVC) as induction therapy in patients with active lupus nephritis. It will test the hypothesis that the use of IVC in conjunction with anti-CD20 will promote emergence of Tregs ..
  10. AUTOIMMUNITY CENTER OF EXCELLENCE
    David Wofsy; Fiscal Year: 2010
    ..a phase Ib/lla trial of anti-CD20 plus cyclophosphamide (IVC) as induction therapy in patients with active lupus nephritis. It will test the hypothesis that the use of IVC in conjunction with anti-CD20 will promote emergence of Tregs ..
  11. OXIDANT MECHANISMS IN MEMBRANOUS NEPHROPATHY
    Sudhir Shah; Fiscal Year: 1990
    ..Passive Heymann nephritis (PHN), induced by a injection of anti-Fx1A, is a complement-dependent and neutrophil-independent model of ..
  12. Urine biomarkers of lupus nephritis pathology and response to therapy
    James C Oates; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Lupus nephritis (LN) results in renal failure in up to 42% of patients after five years...
  13. ADHESION MOLECULES AND GLOMERULONEPHRITIS
    TANYA MAYADAS NORTON; Fiscal Year: 1999
    ..in murine models of glomerulonephritis developed by our group: acute, passive anti- glomerular basement membrane nephritis, complement dependent acute nephrotoxic serum nephritis and accelerated nephrotoxic serum nephritis associated ..
  14. ADHESION MOLECULES AND GLOMERULONEPHRITIS
    TANYA MAYADAS NORTON; Fiscal Year: 2000
    ..in murine models of glomerulonephritis developed by our group: acute, passive anti- glomerular basement membrane nephritis, complement dependent acute nephrotoxic serum nephritis and accelerated nephrotoxic serum nephritis associated ..
  15. Towards Measures of Lupus Nephritis Activity & Damage for Children
    Hermine I Brunner; Fiscal Year: 2010
    ..e. lupus nephritis (LN)...
  16. The Effects of C-Reactive Protein on Autoimmunity
    TERRY DU CLOS; Fiscal Year: 2009
    ..Low levels of CRP expression are associated with increased risk of developing SLE and lupus nephritis. Our studies demonstrated that CRP suppresses disease in mouse models of SLE and other immune complex (IC) ..
  17. CHEMOKINES AND IMMUNE DISEASES
    Lili Feng; Fiscal Year: 1999
    ..coli. dramatically decreased the influx on monocyte/macrophages in experimental tubulointerstitial nephritis (TIN) in rats...
  18. CHEMOKINES AND IMMUNE DISEASES
    Lili Feng; Fiscal Year: 2000
    ..coli. dramatically decreased the influx on monocyte/macrophages in experimental tubulointerstitial nephritis (TIN) in rats...
  19. Role of Estrogen Receptors in Lupus-Modulators of the Inflammatory Response
    Gary Gilkeson; Fiscal Year: 2009
    ..These findings led us to postulate that the primary impact of ER1 deficiency in lupus nephritis was on the response of the kidney to inflammation...
  20. PATHOGENIC ROLE OF THE COMPLEMENT SYSTEM IN MURINE LUPUS
    Richard Quigg; Fiscal Year: 2006
    ..circumstantial and now direct evidence that the complement system is involved in the pathogenesis of lupus nephritis. The work proposed in this application will examine the role of the complement system in renal disease occurring ..
  21. PATHOGENIC ROLE OF THE COMPLEMENT SYSTEM IN MURINE LUPUS
    Richard Quigg; Fiscal Year: 2009
    ..circumstantial and now direct evidence that the complement system is involved in the pathogenesis of lupus nephritis. The work proposed in this application will examine the role of the complement system in renal disease occurring ..
  22. PATHOGENIC ROLE OF THE COMPLEMENT SYSTEM IN MURINE LUPUS
    Richard Quigg; Fiscal Year: 2005
    ..circumstantial and now direct evidence that the complement system is involved in the pathogenesis of lupus nephritis. The work proposed in this application will examine the role of the complement system in renal disease occurring ..
  23. PATHOGENIC ROLE OF THE COMPLEMENT SYSTEM IN MURINE LUPUS
    Richard Quigg; Fiscal Year: 2007
    ..circumstantial and now direct evidence that the complement system is involved in the pathogenesis of lupus nephritis. The work proposed in this application will examine the role of the complement system in renal disease occurring ..
  24. Molecular pathogenesis of anti-glomerular basement membrane nephritis
    Dorin Bogdan Borza; Fiscal Year: 2010
    ..in health, broken in autoimmune anti-GBM disease, or selectively deficient in alloimmune Alport post-transplant nephritis. The objective of this project is to determine at molecular level how the adaptive immune system is abnormally ..
  25. Molecular pathogenesis of anti-glomerular basement membrane nephritis
    Dorin Bogdan Borza; Fiscal Year: 2009
    ..in health, broken in autoimmune anti-GBM disease, or selectively deficient in alloimmune Alport post-transplant nephritis. The objective of this project is to determine at molecular level how the adaptive immune system is abnormally ..
  26. Prediction of Lupus Outcome by Gene Expression Patterns
    Robert Winchester; Fiscal Year: 2006
    ..parent trial compares administration of CellCept versus IV Cytoxan for initiating control of biopsy-proven lupus nephritis. We have demonstrated the feasibility of studying gene expression profiles by microarray analysis in glomeruli ..
  27. Prediction of Lupus Outcome by Gene Expression Patterns
    Robert Winchester; Fiscal Year: 2003
    ..parent trial compares administration of CellCept versus IV Cytoxan for initiating control of biopsy-proven lupus nephritis. We have demonstrated the feasibility of studying gene expression profiles by microarray analysis in glomeruli ..
  28. The Renal Pathogenicity of Anti-DNA Antibodies
    Chaim Putterman; Fiscal Year: 2010
    ..specific for systemic lupus erythematosus (SLE), but are also directly involved in the pathogenesis of lupus nephritis (LN), a major disease manifestation...
  29. The Renal Pathogenicity of Anti-DNA Antibodies
    Chaim Putterman; Fiscal Year: 2009
    ..specific for systemic lupus erythematosus (SLE), but are also directly involved in the pathogenesis of lupus nephritis (LN), a major disease manifestation...
  30. The Renal Pathogenicity of Anti-DNA Antibodies
    Chaim Putterman; Fiscal Year: 2009
    ..specific for systemic lupus erythematosus (SLE), but are also directly involved in the pathogenesis of lupus nephritis (LN), a major disease manifestation...
  31. ROLE OF PPAR GAMMA IN LUPUS NEPHRITIS
    Gary Gilkeson; Fiscal Year: 2004
    ..important insight into the role of PPAR gamma and its ligands in controlling the inflammatory response in lupus nephritis. We and others have shown that the inflammatory response in lupus nephritis can be blocked, decreasing ..
  32. ROLE OF PPAR GAMMA IN LUPUS NEPHRITIS
    Gary Gilkeson; Fiscal Year: 2003
    ..important insight into the role of PPAR gamma and its ligands in controlling the inflammatory response in lupus nephritis. We and others have shown that the inflammatory response in lupus nephritis can be blocked, decreasing ..
  33. ROLE OF PPAR GAMMA IN LUPUS NEPHRITIS
    Gary Gilkeson; Fiscal Year: 2002
    ..important insight into the role of PPAR gamma and its ligands in controlling the inflammatory response in lupus nephritis. We and others have shown that the inflammatory response in lupus nephritis can be blocked, decreasing ..
  34. ROLE OF PPAR GAMMA IN LUPUS NEPHRITIS
    Gary Gilkeson; Fiscal Year: 2005
    ..important insight into the role of PPAR gamma and its ligands in controlling the inflammatory response in lupus nephritis. We and others have shown that the inflammatory response in lupus nephritis can be blocked, decreasing ..
  35. ROLE OF PPAR GAMMA IN LUPUS NEPHRITIS
    Gary Gilkeson; Fiscal Year: 2001
    ..important insight into the role of PPAR gamma and its ligands in controlling the inflammatory response in lupus nephritis. We and others have shown that the inflammatory response in lupus nephritis can be blocked, decreasing ..
  36. CELL MEDIATED RENAL INJURY IN LUPUS
    VICKI KELLEY; Fiscal Year: 2004
    ..renal disease regulated by the lpr gene we will investigate the importance of CSF-1 in the pathogenesis of lupus nephritis. We propose to test whether the increase in circulating CSF-1 detected in neonatal MRL-lpr/lpr mice is ..
  37. CELL MEDIATED RENAL INJURY IN LUPUS
    VICKI KELLEY; Fiscal Year: 2001
    ..renal disease regulated by the lpr gene we will investigate the importance of CSF-1 in the pathogenesis of lupus nephritis. We propose to test whether the increase in circulating CSF-1 detected in neonatal MRL-lpr/lpr mice is ..
  38. CELL MEDIATED RENAL INJURY IN LUPUS
    VICKI KELLEY; Fiscal Year: 2002
    ..renal disease regulated by the lpr gene we will investigate the importance of CSF-1 in the pathogenesis of lupus nephritis. We propose to test whether the increase in circulating CSF-1 detected in neonatal MRL-lpr/lpr mice is ..
  39. CELL MEDIATED RENAL INJURY IN LUPUS
    VICKI KELLEY; Fiscal Year: 1999
    ..renal disease regulated by the lpr gene we will investigate the importance of CSF-1 in the pathogenesis of lupus nephritis. We propose to test whether the increase in circulating CSF-1 detected in neonatal MRL-lpr/lpr mice is ..
  40. CELL MEDIATED RENAL INJURY IN LUPUS
    VICKI KELLEY; Fiscal Year: 2000
    ..renal disease regulated by the lpr gene we will investigate the importance of CSF-1 in the pathogenesis of lupus nephritis. We propose to test whether the increase in circulating CSF-1 detected in neonatal MRL-lpr/lpr mice is ..
  41. CELL MEDIATED RENAL INJURY IN LUPUS
    VICKI KELLEY; Fiscal Year: 2002
    ..renal disease regulated by the lpr gene we will investigate the importance of CSF-1 in the pathogenesis of lupus nephritis. We propose to test whether the increase in circulating CSF-1 detected in neonatal MRL-lpr/lpr mice is ..
  42. CELL MEDIATED RENAL INJURY IN LUPUS
    VICKI KELLEY; Fiscal Year: 2001
    ..renal disease regulated by the lpr gene we will investigate the importance of CSF-1 in the pathogenesis of lupus nephritis. We propose to test whether the increase in circulating CSF-1 detected in neonatal MRL-lpr/lpr mice is ..
  43. CLINICAL CENTER
    David Wofsy; Fiscal Year: 2003
    ..The two proposed clinical trials are: Protocol 1: Treatment of lupus nephritis with CTLA4Ig, a fusion protein that inhibits T cell costimulation via the CD28 pathway...
  44. Cellular and Genetic Basis of Systemic Lupus
    Shu Man Fu; Fiscal Year: 2010
    ..of chronic glomerulonephritis (cGN) respectively in NZM2328, a much studied model for human proliferative lupus nephritis. During the currrent grant period, two informative congenic lines, 290-2 and 507-2 were generated and ..
  45. Human Autoantibodies in Anti-GBM Disease
    Anne Christensen; Fiscal Year: 2004
    ..The studies proposed here seek to identify how autoantibodies against alpha3(IV) initiate nephritis through binding to the GBM...
  46. RCT of GnRH-a for ovarian protection during CYC therapy for rheumatic disease
    WILLIAM J contact MC CUNE; Fiscal Year: 2010
    ..according to evidence-based protocols for treatment of severe rheumatic diseases including lupus nephritis, Wegener's granulomatosis, other forms of pauci-immune vasculitis, and severe interstitial lung disease ..
  47. Biomarkers Based Studies of Polymaviruses
    Abhay Vats; Fiscal Year: 2006
    ..In patients with BKV-associated tubulointerstitial nephritis, a significant risk for graft loss was noted in our studies...
  48. Biomarkers Based Studies of Polyomaviruses
    Abhay Vats; Fiscal Year: 2004
    ..In patients with BKV-associated tubulointerstitial nephritis, a significant risk for graft loss was noted in our studies...
  49. Biomarkers Based Studies of Polymaviruses
    Abhay Vats; Fiscal Year: 2005
    ..In patients with BKV-associated tubulointerstitial nephritis, a significant risk for graft loss was noted in our studies...
  50. Biomarkers Based Studies of Polyomaviruses
    Abhay Vats; Fiscal Year: 2007
    ..In patients with BKV-associated tubulointerstitial nephritis, a significant risk for graft loss was noted in our studies...
  51. Role of Focal Adhesion Kinase (FAK) in Nephrosis and Nephritis
    Shuta Ishibe; Fiscal Year: 2010
    ..The goal of the proposal is to define the mechanisms that are involved during kidney injury and to utilize inhibitors that antagonize against the offending agent(s) responsible for disease progression. ..
  52. Tissue Kallikrein In Immune Mediated Nephritis
    Quan Zhen Li; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): PROJECT SUMMARY/ABSTRACT Immune-mediated nephritis is an important pathogenic determinant in spontaneous lupus and Goodpasture's syndrome (anti-GBM disease), both in mice and in humans...
  53. Tissue Kallikrein In Immune Mediated Nephritis
    Quan Zhen Li; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): PROJECT SUMMARY/ABSTRACT Immune-mediated nephritis is an important pathogenic determinant in spontaneous lupus and Goodpasture's syndrome (anti-GBM disease), both in mice and in humans...
  54. Inhibition of lupus nephritis in IRF-1 deficient mice
    Christopher Reilly; Fiscal Year: 2002
    ..The specific aims described below investigate the role of IFN-y signaling and define the role of IRF-1 in lupus nephritis in MRL/lpr mice...
  55. Inhibition of lupus nephritis in IRF-1 deficient mice
    Christopher Reilly; Fiscal Year: 2003
    ..The specific aims described below investigate the role of IFN-y signaling and define the role of IRF-1 in lupus nephritis in MRL/lpr mice...
  56. Cellular and Genetic Basis of Systemic Lupus
    Shu Man Fu; Fiscal Year: 2003
    ..detected in SLE and the genetic factors important in the generation of ANA and anti-dsDNA antibodies and lupus nephritis. Recently, a new model of SLE NZM2328 has been characterized...
  57. Cellular and Genetic Basis of Systemic Lupus
    Shu Man Fu; Fiscal Year: 2002
    ..detected in SLE and the genetic factors important in the generation of ANA and anti-dsDNA antibodies and lupus nephritis. Recently, a new model of SLE NZM2328 has been characterized...
  58. Cellular and Genetic Basis of Systemic Lupus
    Shu Man Fu; Fiscal Year: 2001
    ..detected in SLE and the genetic factors important in the generation of ANA and anti-dsDNA antibodies and lupus nephritis. Recently, a new model of SLE NZM2328 has been characterized...
  59. Cellular and Genetic Basis of Systemic Lupus
    Shu Man Fu; Fiscal Year: 2004
    ..detected in SLE and the genetic factors important in the generation of ANA and anti-dsDNA antibodies and lupus nephritis. Recently, a new model of SLE NZM2328 has been characterized...
  60. Tertiary lymphoid neogenesis in human lupus nephritis
    Marcus R Clark; Fiscal Year: 2012
    The most frequent severe manifestation of SLE is lupus nephritis (LN)...
  61. Tertiary lymphoid neogenesis in human lupus nephritis
    MARCUS CLARK; Fiscal Year: 2009
    The most frequent severe manifestation of SLE is lupus nephritis (LN)...
  62. Role of reactive intermediates in lupus nephritis
    JAMES C contact OATES; Fiscal Year: 2011
    Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is complicated by lupus nephritis (LN) in approximately 50 percent of cases...
  63. Tertiary lymphoid neogenesis in human lupus nephritis
    Marcus R Clark; Fiscal Year: 2010
    The most frequent severe manifestation of SLE is lupus nephritis (LN)...
  64. Role of reactive intermediates in lupus nephritis
    Gary Gilkeson; Fiscal Year: 2009
    Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is complicated by lupus nephritis (LN) in approximately 50 percent of cases...
  65. Role of reactive intermediates in lupus nephritis
    James C Oates; Fiscal Year: 2010
    Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is complicated by lupus nephritis (LN) in approximately 50 percent of cases...
  66. IMMUNOGENETICS OF ANTIBODY INDUCED NEPHRITIS
    Chandra Mohan; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Experimental Autoantibody Induced Glomerulo Nephritis (AIGN) elicited by the adoptive transfer of anti-GBM (or anti-glomerular) Abs is a good model of human anti- GBM/Goodpasture's disease...
  67. Human Autoantibodies in Anti-GBM Disease
    Anne Christensen; Fiscal Year: 2005
    ..The studies proposed here seek to identify how autoantibodies against alpha3(IV) initiate nephritis through binding to the GBM...
  68. Human Autoantibodies in Anti-GBM Disease
    Anne Christensen; Fiscal Year: 2003
    ..The studies proposed here seek to identify how autoantibodies against alpha3(IV) initiate nephritis through binding to the GBM...
  69. ACE INHIBITORS IN LUPUS NEPHRITIS--TGFB AND AUTOANTIBODY PRODUCTION
    Ram Singh; Fiscal Year: 2001
    ..will explore potential therapeutic and damaging effects of ACEIs in SLE, inflammatory component of lupus nephritis, its continued presence enhances renal matrix deposition and fibrosis...
  70. IMMUNOLOGIC MECHANISMS OF LUPUS NEPHRITIS
    Michael Madaio; Fiscal Year: 1993
    ..per se, are critical for and contribute to the observed variations in the phenotypic expression of lupus nephritis, and they emphasize the disease relevance of both the Ag binding regions of pathogenic autoAb and the glomerular ..
  71. Sociodemographic Disparities in Lupus Nephritis: Healthcare Access and Outcomes
    Karen Costenbader; Fiscal Year: 2009
    ..S. Systemic lupus erythematosus (lupus), a complex autoimmune disease, can cause nephritis and, in severe cases, end-stage renal disease...
  72. Membranous Nephritis Antigen Defined by Phage Antibodies
    Sudesh Makker; Fiscal Year: 2007
    ..when patients first present with full-blown nephrotic syndrome is supported by similar observation in Heymann nephritis, a rat model of MGN...
  73. PHOSPHATE TOXICITY IN END-STAGE KIDNEY FAILURE
    ALLEN ALFREY; Fiscal Year: 1980
    ..established in two types of experimental renal disease in rats, the remnant kidney model and nephrotoxic serum nephritis models, that phosphorus restriction prevents renal functional deterioration and histological damage...
  74. Membranous Nephritis Antigen Defined by Phage Antibodies
    Sudesh Makker; Fiscal Year: 2006
    ..when patients first present with full-blown nephrotic syndrome is supported by similar observation in Heymann nephritis, a rat model of MGN...
  75. ROLE OF COMPLEMENT FACTOR B IN THE PATHOGENESIS OF SLE
    Gary Gilkeson; Fiscal Year: 2001
    ..cascade plays an important role in the pathogenesis of immune complex mediated diseases, including lupus nephritis. The alternative complement pathway is activated in lupus nephritis, though its role in the pathogenesis of ..
  76. ROLE OF COMPLEMENT FACTOR B IN THE PATHOGENESIS OF SLE
    Gary Gilkeson; Fiscal Year: 2003
    ..cascade plays an important role in the pathogenesis of immune complex mediated diseases, including lupus nephritis. The alternative complement pathway is activated in lupus nephritis, though its role in the pathogenesis of ..