cryptorchidism

Summary

Summary: A developmental defect in which a TESTIS or both TESTES failed to descend from high in the ABDOMEN to the bottom of the SCROTUM. Testicular descent is essential to normal SPERMATOGENESIS which requires temperature lower than the BODY TEMPERATURE. Cryptorchidism can be subclassified by the location of the maldescended testis.

Top Publications

  1. pmc Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism
    Michelle Welsh
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Clin Invest 118:1479-90. 2008
  2. ncbi Cryptorchidism and hypospadias as a sign of testicular dysgenesis syndrome (TDS): environmental connection
    Jorma Toppari
    Departments of Physiology and Pediatrics, University of Turku, Kiinamyllynkatu 10, Turku, Finland
    Birth Defects Res A Clin Mol Teratol 88:910-9. 2010
  3. ncbi Spermatogenesis in cryptorchidism
    Alexander I Agoulnik
    Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA
    Methods Mol Biol 825:127-47. 2012
  4. ncbi Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects
    N E Skakkebaek
    Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark
    Hum Reprod 16:972-8. 2001
  5. ncbi Insulin-like 3 signalling in testicular descent
    Ibrahim M Adham
    Institute of Human Genetics, University of Gottingen, Gottingen, Germany
    Int J Androl 27:257-65. 2004
  6. pmc Cryptorchidism and maternal alcohol consumption during pregnancy
    Ida N Damgaard
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Environ Health Perspect 115:272-7. 2007
  7. ncbi An oligonucleotide microarray study on gene expression profile in mouse testis of experimental cryptorchidism
    Yin Chuan Li
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, P R China
    Front Biosci 11:2465-82. 2006
  8. ncbi Insulin-like 3 signaling is important for testicular descent but dispensable for spermatogenesis and germ cell survival in adult mice
    Zaohua Huang
    Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, USA
    Biol Reprod 87:143. 2012
  9. ncbi Intrauterine exposure to mild analgesics during pregnancy and the occurrence of cryptorchidism and hypospadia in the offspring: the Generation R Study
    Claudia A Snijder
    The Generation R Study Group, Erasmus University Medical Centre, Dr Molewaterplein 50 60, 3015 GE Rotterdam, The Netherlands
    Hum Reprod 27:1191-201. 2012
  10. pmc Associations between congenital cryptorchidism in newborn boys and levels of dioxins and PCBs in placenta
    H E Virtanen
    Departments of Physiology and Paediatrics, University of Turku, Turku, Finland
    Int J Androl 35:283-93. 2012

Detail Information

Publications268 found, 100 shown here

  1. pmc Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism
    Michelle Welsh
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Clin Invest 118:1479-90. 2008
    ..Disorders of fetal masculinization, resulting in hypospadias or cryptorchidism, are common, but their cause remains unclear...
  2. ncbi Cryptorchidism and hypospadias as a sign of testicular dysgenesis syndrome (TDS): environmental connection
    Jorma Toppari
    Departments of Physiology and Pediatrics, University of Turku, Kiinamyllynkatu 10, Turku, Finland
    Birth Defects Res A Clin Mol Teratol 88:910-9. 2010
    b>Cryptorchidism and hypospadias are common genital birth defects that affect 2-9% and 0.2-1% of male newborns, respectively...
  3. ncbi Spermatogenesis in cryptorchidism
    Alexander I Agoulnik
    Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA
    Methods Mol Biol 825:127-47. 2012
    b>Cryptorchidism or undescended testis is the most frequent congenital abnormality in newborn boys. The process of testicular descent to the scrotum is controlled by hormones produced in Leydig cells, insulin-like3, and androgens...
  4. ncbi Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects
    N E Skakkebaek
    Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark
    Hum Reprod 16:972-8. 2001
    ..Otherwise, important biological information may be lost...
  5. ncbi Insulin-like 3 signalling in testicular descent
    Ibrahim M Adham
    Institute of Human Genetics, University of Gottingen, Gottingen, Germany
    Int J Androl 27:257-65. 2004
    Undescended testis is one of the most common congenital defects in the newborn boys and the common cause of cryptorchidism. If left untreated, this condition is strongly associated with infertility and drastically increased risk of ..
  6. pmc Cryptorchidism and maternal alcohol consumption during pregnancy
    Ida N Damgaard
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Environ Health Perspect 115:272-7. 2007
    Prenatal exposure to alcohol can adversely affect the fetus. We investigated the association between maternal alcohol consumption during pregnancy and cryptorchidism (undescended testis) among newborn boys.
  7. ncbi An oligonucleotide microarray study on gene expression profile in mouse testis of experimental cryptorchidism
    Yin Chuan Li
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, P R China
    Front Biosci 11:2465-82. 2006
    ..patterns on day 1, day 4, day 7, day 14, day 28 and normal control adult mouse testis after experimental cryptorchidism (EC) using Affymetrix MOE430A microarray...
  8. ncbi Insulin-like 3 signaling is important for testicular descent but dispensable for spermatogenesis and germ cell survival in adult mice
    Zaohua Huang
    Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, USA
    Biol Reprod 87:143. 2012
    ..Deletion of Insl3 or Rxfp2 genes in mice caused cryptorchidism resulting from a failure of gubernaculum development...
  9. ncbi Intrauterine exposure to mild analgesics during pregnancy and the occurrence of cryptorchidism and hypospadia in the offspring: the Generation R Study
    Claudia A Snijder
    The Generation R Study Group, Erasmus University Medical Centre, Dr Molewaterplein 50 60, 3015 GE Rotterdam, The Netherlands
    Hum Reprod 27:1191-201. 2012
    ..We examined the influence of maternal exposure to mild analgesics during pregnancy on the occurrence of cryptorchidism and hypospadia in their offspring.
  10. pmc Associations between congenital cryptorchidism in newborn boys and levels of dioxins and PCBs in placenta
    H E Virtanen
    Departments of Physiology and Paediatrics, University of Turku, Turku, Finland
    Int J Androl 35:283-93. 2012
    ..In addition, one previous case-control study has reported an association between congenital cryptorchidism and colostrum PCB levels...
  11. ncbi Cryptorchidism-induced CFTR down-regulation results in disruption of testicular tight junctions through up-regulation of NF-κB/COX-2/PGE2
    Jing Chen
    Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Hum Reprod 27:2585-97. 2012
    ..conductance regulator (CFTR) down-regulation in Sertoli cells in cryptorchid testis disrupt testicular tight junctions (TJs) through the nuclear factor kappa B (NF-κB)/cyclooxygenase-2 (COX-2)/prostaglandin E(2) (PGE(2)) pathway?..
  12. ncbi INSL3/LGR8 role in testicular descent and cryptorchidism
    N V Bogatcheva
    Department of Obstetrics and Gynecology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Reprod Biomed Online 10:49-54. 2005
    b>Cryptorchidism, generally referred to a failure of testicular descent into the scrotum, is the most frequent (up to 3-4% at birth) congenital anomaly in newborn boys...
  13. ncbi Maternal use of acetaminophen, ibuprofen, and acetylsalicylic acid during pregnancy and risk of cryptorchidism
    Morten Søndergaard Jensen
    Perinatal Epidemiology Research Unit, Departments of Obstetrics and Pediatrics, Aarhus University Hospital, Skejby, Denmark
    Epidemiology 21:779-85. 2010
    ..We examined whether prenatal exposure to acetaminophen, ibuprofen, and acetylsalicylic acid was associated with increased occurrence of cryptorchidism.
  14. ncbi Cryptorchidism
    John M Hutson
    Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia
    Semin Pediatr Surg 19:215-24. 2010
    b>Cryptorchidism is a very common anomaly of the male genitalia, affecting 2%-4% of male infants and is more common in premature infants. There are two separate stages of testicular descent...
  15. ncbi The descriptive epidemiology of congenital and acquired cryptorchidism in a UK infant cohort
    C L Acerini
    Department of Paediatrics, University of Cambridge, Cambridge, UK
    Arch Dis Child 94:868-72. 2009
    Recent studies in other European countries suggest that the prevalence of congenital cryptorchidism continues to increase. This study aimed to explore the prevalence and natural history of congenital cryptorchidism in a UK centre.
  16. ncbi Epidemiology and pathogenesis of cryptorchidism
    H E Virtanen
    Department of Physiology, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Hum Reprod Update 14:49-58. 2008
    Prospective clinical studies have shown that the prevalence of cryptorchidism among boys with birth weight > or =2500 g has increased in UK from 2.7 to 4.1% between the 1950s and the 1980s and in Denmark from 1.8 to 8...
  17. pmc Maternal smoking, alcohol consumption, and caffeine consumption during pregnancy in relation to a son's risk of persistent cryptorchidism: a prospective study in the Child Health and Development Studies cohort, 1959-1967
    Morgana L Mongraw-Chaffin
    Child Health and Development Studies, Center for Research on Women s and Children s Health, Public Health Institute, Berkeley 94709, CA
    Am J Epidemiol 167:257-61. 2008
    ..Other maternal and perinatal risk factors were not significantly associated with persistent cryptorchidism and did not confound the association with caffeine.
  18. ncbi Impaired Leydig cell function in infertile men: a study of 357 idiopathic infertile men and 318 proven fertile controls
    A M Andersson
    Department of Growth and Reproduction, Copenhagen University Hospital, Section GR 5064, Blegdamsvej 9, DK 2100 Copenhagen OE, Denmark
    J Clin Endocrinol Metab 89:3161-7. 2004
    ..On the other hand, the parallel impairment of spermatogenesis and Leydig cells may reflect a congenital dysfunction of both compartments caused by a testicular dysgenesis during fetal/infant development...
  19. ncbi Cryptorchidism in mice mutant for Insl3
    S Nef
    Center for Developmental Biology, University of Texas Southwestern Medical Center, Dallas 75235 9133, USA
    Nat Genet 22:295-9. 1999
    Impaired testicular descent (cryptorchidism) is one of the most frequent congenital abnormalities in humans, involving 2% of male births. Cryptorchidism can result in infertility and increases risk for development of germ-cell tumours...
  20. ncbi The possible role of endocrine disrupting chemicals in the aetiology of cryptorchidism and hypospadias: a population-based case-control study in rural Sicily
    P Carbone
    Department of Animal and Human Biology, University of Rome La Sapienza, Rome, Italy
    Int J Androl 30:3-13. 2007
    ..and domestic exposures to potential endocrine disrupting chemicals (EDC) assessed by questionnaire and cryptorchidism and hypospadias in their offspring in the agricultural area of Ragusa...
  21. ncbi Estrogen receptor alpha is a major contributor to estrogen-mediated fetal testis dysgenesis and cryptorchidism
    Christopher R Cederroth
    Department of Genetic Medicine and Development University of Geneva Medical School 1, rue Michel Servet, CH 1211, Geneva 4, Switzerland
    Endocrinology 148:5507-19. 2007
    Failure of the testes to descend into the scrotum (cryptorchidism) is one of the most common birth defects in humans...
  22. ncbi Insulin-like factor 3 gene mutations in testicular dysgenesis syndrome: clinical and functional characterization
    A Ferlin
    Department of Histology, Microbiology and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy
    Mol Hum Reprod 12:401-6. 2006
    ..or its G protein-coupled receptor, leucine-rich repeat-containing G-protein-coupled receptor (Lgr8), causes cryptorchidism in mice...
  23. ncbi 13 Years' experience with the combined hormonal therapy of cryptorchidism
    M F Giannopoulos
    Clinic of Pediatric Surgery, University Hospital Heraklion, University of Crete, Heraklion, Crete, Greece
    Horm Res 55:33-7. 2001
    ..hormone releasing hormone (LH-RH) and human chorionic gonadotropin (HCG) of a large series of patients with cryptorchidism. MATERIALS AND METHODS: Between 1987 and 1999 and after strict differentiation between cryptorchid, retractile ..
  24. ncbi Importance of early postnatal germ cell maturation for fertility of cryptorchid males
    F Hadziselimovic
    Kindertagesklinik, Liestal, Switzerland
    Horm Res 55:6-10. 2001
    ..This underscores the importance of a testicular biopsy at orchidopexy in order to identify those who could benefit from early LH-RH treatment after orchidopexy...
  25. ncbi The CAG repeat within the androgen receptor gene and its relationship to cryptorchidism
    M Silva-Ramos
    Department of Urology, Santo Antonio General Hospital, Porto, Portugal
    Int Braz J Urol 32:330-4; discussion 335. 2006
    We examined the significance of the CAG repeat polymorphism in the pathogenesis of cryptorchidism.
  26. ncbi Prenatal alcohol exposure and cryptorchidism
    M S Jensen
    Department of Occupational Medicine, University Hospital of Aarhus, Aarhus, Denmark
    Acta Paediatr 96:1681-5. 2007
    A recently published study reported markedly increased risk of cryptorchidism among boys whose mothers had an average gestational alcohol intake of five or more drinks per week...
  27. ncbi Insulin-like factor 3 levels in cord blood and serum from children: effects of age, postnatal hypothalamic-pituitary-gonadal axis activation, and cryptorchidism
    Katrine Bay
    University Department of Growth and Reproduction, Rigshospitalet, GR 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 92:4020-7. 2007
    The Leydig cell hormone insulin-like factor 3 (INSL3) is important for testicular descent. Currently INSL3 levels in cord blood, in serum throughout childhood, and in relation to congenital cryptorchidism are unknown.
  28. pmc Differential gene expression in the testes of different murine strains under normal and hyperthermic conditions
    Ying Li
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA
    J Androl 30:325-37. 2009
    b>Cryptorchidism and scrotal heating result in abnormal spermatogenesis, but the mechanism(s) prescribing this temperature sensitivity are unknown...
  29. ncbi A transgenic insertion causing cryptorchidism in mice
    P A Overbeek
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    Genesis 30:26-35. 2001
    ..Failure in this process results in cryptorchidism, a frequent congenital birth defect in humans...
  30. ncbi Attenuation of spermatogonial stem cell activity in cryptorchid testes
    Hideyuki Kamisawa
    Department of Nephro urology, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan
    J Urol 187:1047-52. 2012
    To elucidate the mechanism of infertility caused by cryptorchidism we focused on early stage spermatogenesis and spermatogonial stem cell activity in undifferentiated spermatogonia in cryptorchid testes.
  31. ncbi Inadvertent exposure to xenoestrogens in children
    N Olea
    Laboratory of Medical Investigations, School of Medicine, University of Granada, Spain
    Toxicol Ind Health 15:151-8. 1999
    ..with a hypothetical association between exposure to hormone-disruptive chemicals and the induction of cryptorchidism. Several methodological limitations in the study design make it necessary to evaluate the results with caution...
  32. ncbi Association between chemical pattern in breast milk and congenital cryptorchidism: modelling of complex human exposures
    K Krysiak-Baltyn
    Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark
    Int J Androl 35:294-302. 2012
    ..To study the association between complex chemical exposures of humans and congenital cryptorchidism, the most common malformation of the male genitalia, we measured 121 environmental chemicals with suspected or ..
  33. ncbi Cryopreservation of intact testicular tissue from boys with cryptorchidism
    K Kvist
    Laboratory of Reproductive Biology, Section 5712, Department of Paediatric Surgery, Section 4072, University Hospital of Copenhagen, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Hum Reprod 21:484-91. 2006
    Boys with cryptorchidism often face fertility problems in adult life despite having orchiopexy performed at a very young age...
  34. ncbi Hormonal changes in 3-month-old cryptorchid boys
    Anne Maarit Suomi
    Department of Physiology and Pediatrics, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    J Clin Endocrinol Metab 91:953-8. 2006
    Hormonal dysregulation has been suggested to be one of many etiological factors of cryptorchidism.
  35. ncbi The incidence of bilateral cryptorchidism is increased and the fertility potential is reduced in sons born to mothers who have smoked during pregnancy
    J Thorup
    Department of Pediatric Surgery, Rigshospitalet, University of Copenhagen, Denmark
    J Urol 176:734-7. 2006
    Recent studies have demonstrated a high prevalence of cryptorchidism, decreasing semen quality and increasing incidence of testicular cancer...
  36. ncbi The importance of mini-puberty for fertility in cryptorchidism
    Faruk Hadziselimovic
    Department of Pediatrics, Kindertagesklinik, Oristalstrasse, Liestal, Switzerland
    J Urol 174:1536-9; discussion 1538-9. 2005
    ..It induces the development and transformation of gonocytes into Ad spermatogonia, which is impaired in many cryptorchid testes. We examine the role of testosterone in the transformation and development of Ad spermatogonia...
  37. pmc Cryptorchidism in mice with an androgen receptor ablation in gubernaculum testis
    Elena M Kaftanovskaya
    Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8th Street, Miami, Florida 33199, USA
    Mol Endocrinol 26:598-607. 2012
    ..The GU-ARKO males had normal testosterone levels but developed cryptorchidism with the testes located in a suprascrotal position...
  38. ncbi Absence of mutations involving the INSL3 gene in human idiopathic cryptorchidism
    C Krausz
    Immunogenetique Humaine, INSERM U276, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Mol Hum Reprod 6:298-302. 2000
    The aetiology of cryptorchidism is for the most part unknown and appears to be multifactorial...
  39. ncbi The anatomy of the cremaster muscle during inguinoscrotal testicular descent in the rat
    Efrant J Harnaen
    F Douglas Stephens Surgical Research Laboratory, Murdoch Childrens Research Institute, Melbourne, Australia
    J Pediatr Surg 42:1982-7. 2007
    ..This study investigated cremaster muscle anatomy and ontogeny in both normal and cryptorchid rat models...
  40. ncbi Retractile testis--is it really a normal variant?
    Piyush K Agarwal
    Division of Pediatric Urology, Rainbow Babies and Children s Hospital, Cleveland, Ohio, USA
    J Urol 175:1496-9. 2006
    ..Retractile testes are thought to represent a normal variant of descended testes in prepubertal boys. We studied retractile testes to determine their natural history...
  41. ncbi Maternal diet and the risk of hypospadias and cryptorchidism in the offspring
    Felice Giordano
    Department of Animal and Human Biology, University of Rome La Sapienza, Rome, Italy
    Paediatr Perinat Epidemiol 22:249-60. 2008
    ..The purpose of this study was to explore the association between hypospadias and cryptorchidism, and the dietary habits of an agricultural population in Italy...
  42. ncbi Cryptorchidism in common eutherian mammals
    R P Amann
    Animal Reproduction and Biotechnology Laboratory, Colorado State University, Fort Collins, Colorado 80523 1683, USA
    Reproduction 133:541-61. 2007
    b>Cryptorchidism is failure of one or both testes to descend into the scrotum. Primary fault lies in the testis. We provide a unifying cross-species interpretation of testis descent and urge the use of precise terminology...
  43. ncbi Morphometric study of the gubernaculum in male estrogen receptor mutant mice
    K M Donaldson
    F Douglas Stephens Surgical Research Laboratory, Royal Children s Hospital Research Foundation, Melbourne, Australia
    J Androl 17:91-5. 1996
    ..This study demonstrates that estrogen has a previously unknown role in masculine sexual development of the gubernaculum and the structures derived from it, such as the cremaster muscle...
  44. ncbi Altered expression of muscle- and cytoskeleton-related genes in a rat strain with inherited cryptorchidism
    Julia S Barthold
    Nemours Biomedical Research and Division of Urology, A I duPont Hospital for Children, Wilmington, Delaware 19803, USA
    J Androl 29:352-66. 2008
    ..These data suggest that the orl mutation results in a primary gubernacular defect that affects muscle development and cytoskeletal function and might alter androgen-regulated pathways...
  45. ncbi Hormonal cryptorchidism therapy: systematic review with metanalysis of randomized clinical trials
    Márcia Riromi Henna
    Pediatr Surg Int 20:357-9. 2004
    The importance of cryptorchidism treatment concerns the possibility of diminishing risk of malignant degeneration and improving fertility...
  46. ncbi Mutations of the GREAT gene cause cryptorchidism
    Ivan P Gorlov
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 11:2309-18. 2002
    In humans, failure of testicular descent (cryptorchidism) is one of the most frequent congenital malformations, affecting 1-3% of newborn boys...
  47. ncbi Cryptorchidism: an indicator of testicular dysgenesis?
    Marko Kaleva
    Department of Physiology, University of Turku, 20520 Turku, Finland
    Cell Tissue Res 322:167-72. 2005
    b>Cryptorchidism is a common ailment of new-born boys, affecting 1-9% of full term boys at birth. Cryptorchidism has been associated with an increased risk of testicular cancer and reduced fertility...
  48. ncbi Accuracy of ultrasonography and magnetic resonance imaging in the diagnosis of non-palpable testis
    Kazuhiro Kanemoto
    Department of Nephro urology and Quantum Radiology, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan
    Int J Urol 12:668-72. 2005
    ..Studies were needed to evaluate the accuracy of ultrasonography (US) and magnetic resonance imaging (MRI) for diagnosing non-palpable testis, and to study the clinical usefulness of US and MRI before surgical exploration...
  49. ncbi Prepubertal orchiopexy for cryptorchidism may be associated with lower risk of testicular cancer
    Thomas J Walsh
    Department of Urology, University of California San Francisco, San Francisco, California 94143 1695, USA
    J Urol 178:1440-6; discussion 1446. 2007
    ..We hypothesize that early orchiopexy is protective against subsequent development of testicular germ cell cancer...
  50. ncbi The insulin-3 gene: lack of a genetic basis for human cryptorchidism
    Linda A Baker
    John W Duckett, M D Laboratory in Pediatric Urology, Department of Urology and Center for Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    J Urol 167:2534-7. 2002
    The etiology of cryptorchidism appears to be multifactorial and related to hormonal and mechanical factors. Recently, the insulin-3 gene (INSL3) was noted to have a role in mouse gubernacular development and testicular descent...
  51. ncbi Cryptorchidism: aspects of fertility and neoplasms. A study including data of 1,335 consecutive boys who underwent testicular biopsy simultaneously with surgery for cryptorchidism
    D Cortes
    Department of Pediatric Surgery, Rigshospitalet, Denmark
    Horm Res 55:21-7. 2001
    PURPOSE: An attempt to make a rational strategy for treatment of cryptorchidism. MATERIALS AND METHODS: 1,335 cryptorchid boys with biopsy at surgery (1,638 specimens)...
  52. ncbi Association of variants in genes involved in environmental chemical metabolism and risk of cryptorchidism and hypospadias
    Xian Yang Qin
    Research Center for Environmental Risk, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    J Hum Genet 57:434-41. 2012
    ..ARNT, ARNT2, NR1I2, RXRA, RXRB, RXRG, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP3A4, CYP17A1 and CYP19A1) and risk of cryptorchidism (CO) and hypospadias (HS) in 334 Japanese (JPN) males (141 controls, 95 CO and 98 HS) and 187 Italian (ITA) ..
  53. ncbi A critical appraisal of the evidence for improved fertility indices in undescended testes after gonadotrophin-releasing hormone therapy and orchidopexy
    S M Biers
    Department of Paediatric Urology, Southampton General Hospital, Division of Women and Children, Care Group Child Health MP43, G Level East Wing, Tremona Road, Southampton, Hampshire SO16 6YD, UK
    J Pediatr Urol 6:239-46. 2010
    ..We suggest that the evidence is sufficiently strong to recommend a change in clinical practice...
  54. ncbi Fertility after bilateral cryptorchidism. Evaluation by paternity, hormone, and semen data
    P A Lee
    Graduate School of Public Health, University of Pittsburgh, PA, USA
    Horm Res 55:28-32. 2001
    ..Evaluation of the fertility of a cohort of formerly bilaterally cryptorchid men in comparison with a group of formerly unilaterally cryptorchid men, and a group of control men...
  55. pmc Diagnostic performance of ultrasound in nonpalpable cryptorchidism: a systematic review and meta-analysis
    Gregory E Tasian
    Department of Urology, University of California, San Francisco, CA 94143 0738, USA
    Pediatrics 127:119-28. 2011
    ..Ultrasound is frequently obtained during the presurgical evaluation of boys with nonpalpable undescended testes, but its clinical utility is uncertain...
  56. ncbi Management of cryptorchidism in children: guidelines
    Christophe Gapany
    Service of Pediatric Surgery, Centre Hospitalier Universitaire Vaudois, and University of Lausanne, Lausanne, Switzerland
    Swiss Med Wkly 138:492-8. 2008
    To develop clinical guidelines for the management of cryptorchidism in pre-pubertal boys, from early diagnosis through therapy to long-term follow-up and prognosis.
  57. ncbi Testicular histology related to fertility outcome and postpubertal hormone status in cryptorchidism
    F Hadziselimovic
    Kindertagesklinik Liestal, Liestal, Switzerland
    Klin Padiatr 220:302-7. 2008
    ..However, in boys with cryptorchidism early successful surgery cannot prevent infertility if they lack Ad spermatogonia...
  58. ncbi Testicular descent and cryptorchidism: the state of the art in 2004
    John M Hutson
    F Douglas Stephens Surgical Research Laboratory, Murdoch Children s Research Institute, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    J Pediatr Surg 40:297-302. 2005
    ..Recent advances include the recognition of acquired cryptorchidism of critical early postnatal germ cell development and the recommendation for surgery at 6 months of age...
  59. pmc Maternal pregnancy levels of polychlorinated biphenyls and risk of hypospadias and cryptorchidism in male offspring
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, 6120 Executive Blvd, Rockville, MD 20852 7234, USA
    Environ Health Perspect 117:1472-6. 2009
    The etiologies of the male urogenital anomalies cryptorchidism and hypospadias are poorly understood. It has been suggested, however, that in utero hormone levels may be related to risk...
  60. ncbi Serum concentrations of Anti-Müllerian Hormone (AMH) in 95 patients with Klinefelter syndrome with or without cryptorchidism
    Lise Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Acta Paediatr 100:839-45. 2011
    ..AMH is a testis-specific marker of diagnostic value in infants with ambiguous genitalia or with bilateral cryptorchidism. However, little is known about AMH in boys and adult men with normal or abnormal gonadal function...
  61. ncbi Surgical treatment of unilaterally undescended testes: testicular growth after randomization to orchiopexy at age 9 months or 3 years
    Claude Kollin
    Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden
    J Urol 178:1589-93; discussion 1593. 2007
    ..We compared the growth of congenital, unilaterally undescended testes following orchiopexy at age 9 months or 3 years...
  62. ncbi Advances in molecular genetics of cryptorchidism
    Yoshiyuki Kojima
    Department of Nephro urology, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    Urology 74:571-8. 2009
    b>Cryptorchidism is the most common congenital disorder in boys; one major complication of this disorder is male infertility...
  63. ncbi Age at surgery for undescended testis and risk of testicular cancer
    Andreas Pettersson
    Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    N Engl J Med 356:1835-41. 2007
    ..We studied the relation between the age at treatment for undescended testis and the risk of testicular cancer...
  64. ncbi Cryptorchidism: classification, prevalence and long-term consequences
    Helena E Virtanen
    Department of Physiology, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
    Acta Paediatr 96:611-6. 2007
    ..There are unexplained geographical differences and temporal trends in its prevalence. Cryptorchidism, especially bilateral, is associated with impaired spermatogenesis and endocrine function and increases the ..
  65. ncbi Androgen receptor gene CAG and GGC repeat lengths in cryptorchidism
    Alberto Ferlin
    University of Padova, Department of Histology, Microbiology, and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, 35121 Padova, Italy
    Eur J Endocrinol 152:419-25. 2005
    b>Cryptorchidism is the most common congenital birth defect in male children, and accumulating evidence suggests that genetic abnormalities may be associated with it...
  66. ncbi Acquired cryptorchidism is frequent in infancy and childhood
    Christine Wohlfahrt-Veje
    University Department of Growth and Reproduction, GR 5064 Rigshospitalet, Copenhagen, Denmark
    Int J Androl 32:423-8. 2009
    Accurate prevalence data for acquired cryptorchidism are currently sparse and systematic prospective studies have not yet been reported. Our aim was to determine the prevalence of testicular ascent in childhood...
  67. ncbi Cryptorchidism concordance in monozygotic and dizygotic twin brothers, full brothers, and half-brothers
    Morten Søndergaard Jensen
    Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark
    Fertil Steril 93:124-9. 2010
    To study concordance rates of cryptorchidism (undescended testis) in pairs of boys with varying family structure, to evaluate the risk contribution from the intrauterine environment and genetic factors.
  68. ncbi Associations among hypospadias, cryptorchidism, anogenital distance, and endocrine disruption
    Michael H Hsieh
    Scott Department of Urology, Texas Children s Hospital, Clinical Care Center, Baylor College of Medicine, Suite 660, 6621 Fannin Street, Houston, TX 77030, USA
    Curr Urol Rep 9:137-42. 2008
    ..disruptors, such as environmental compounds with endocrine-altering properties, may cause hypospadias and cryptorchidism in several species, including humans...
  69. ncbi Abnormal germ cell development in cryptorchidism
    D S Huff
    Department of Pathology and Division of Pediatric Urology, Childrens Hospital of Philadelphia, PA 19104, USA
    Horm Res 55:11-7. 2001
    ..The purpose of this study is to confirm the previous findings of defective germ cell maturation in a large series of boys with unilateral undescended testes...
  70. ncbi Targeted disruption of the Insl3 gene causes bilateral cryptorchidism
    S Zimmermann
    Institut für Humangenetik der Universität Göttingen, Germany
    Mol Endocrinol 13:681-91. 1999
    ..Here we show that male mice homozygous for a targeted deletion of the Insl3 locus exhibit bilateral cryptorchidism with free moving testes and genital ducts...
  71. ncbi Functional analysis of spermatogonial stem cells in Steel and cryptorchid infertile mouse models
    T Shinohara
    Department of Animal Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Dev Biol 220:401-11. 2000
    ..Thus, cryptorchid testes provide an important approach for purification and characterization of spermatogonial stem cells...
  72. ncbi Anti-Müllerian hormone levels in serum from human foetuses and children: pattern and clinical interest
    J Guibourdenche
    Department of Biochemistry, Hopital Robert Debre, 48 Boulevard Serurier, 75019 Paris, France
    Mol Cell Endocrinol 211:55-63. 2003
    ..When testes cannot be palpated, a single determination of serum AMH levels can distinguish between anorchia and cryptorchidism.
  73. ncbi Cryptorchidism and testicular cancer: separating fact from fiction
    Hadley M Wood
    Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 48202, USA
    J Urol 181:452-61. 2009
    We dissected prevailing assumptions about cryptorchidism and reviewed data that support and reject these assumptions.
  74. ncbi Reproductive dysgenesis in wildlife: a comparative view
    Thea M Edwards
    Department of Zoology, University of Florida, Gainesville, 32611, USA
    Int J Androl 29:109-21. 2006
    ..TDS is also described as demasculinization or feminization of the male phenotype. The suite includes cryptorchidism, in situ germ cell carcinoma of the testis and overt testicular cancer, reduced semen quality, and hypospadias...
  75. ncbi Development and descent of the testis in relation to cryptorchidism
    Helena E Virtanen
    Department of Physiology, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Acta Paediatr 96:622-7. 2007
    ..In general, the cause of cryptorchidism is unknown and the aetiology is possibly multifactorial...
  76. pmc Suppression of insulin-like3 receptor reveals the role of β-catenin and Notch signaling in gubernaculum development
    Elena M Kaftanovskaya
    Department of Human Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA
    Mol Endocrinol 25:170-83. 2011
    ..Deletion of Insl3 or its receptor, Rxfp2, in mice causes cryptorchidism. We produced Cre/loxP regulated shRNA transgenic mice targeting RXFP2 expression...
  77. ncbi Testicular sperm extraction with intracytoplasmic sperm injection is successful for the treatment of nonobstructive azoospermia associated with cryptorchidism
    Jay D Raman
    James Buchanan Brady Urology Foundation, Department of Urology, Center for Male Reproductive Medicine and Microsurgery, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, New York, USA
    J Urol 170:1287-90. 2003
    We evaluated the results of testicular sperm extraction (TESE) with intracytoplasmic sperm injection (ICSI) in men with nonobstructive azoospermia (NOA) associated with cryptorchidism.
  78. pmc The undescended testis: diagnosis, treatment and long-term consequences
    Michael J Mathers
    Urologische Gemeinschaftspraxis Remscheid, Kooperationspraxis der Klinik für Urologie und Kinderurologie, Klinikum Wuppertal, Universitat Witten Herdecke
    Dtsch Arztebl Int 106:527-32. 2009
    ..Reduced fertility is the main risk of primary cryptorchidism even after timely treatment, as histopathological changes (Leydig cell hypoplasia) already become apparent in ..
  79. ncbi Results of orchiopexy for the undescended testis
    Irina Taran
    Division of Pediatric Urology, Rainbow Babies and Children s Hospital, Department of Urology, Case School of Medicine, Cleveland, OH 44106, USA
    World J Urol 24:231-9. 2006
    ..The risk of testicular carcinoma is increased by a factor of 3.7 to 7.5 times. Tumor type is most commonly seminoma if the testis is undescended, whereas tumors that occur following orchiopexy are much more likely to be nonseminomatous...
  80. ncbi Higher than expected prevalence of congenital cryptorchidism in Lithuania: a study of 1204 boys at birth and 1 year follow-up
    R T Preiksa
    Institute of Endocrinology, Kaunas University of Medicine, LT 50009 Kaunas, Lithuania
    Hum Reprod 20:1928-32. 2005
    b>Cryptorchidism at birth is one of the symptoms of testicular dysgenesis syndrome (TDS). The aim of the study was to detect prevalence of cryptorchidism in Lithuanian newborn boys.
  81. ncbi Parental and neonatal risk factors for cryptorchidism
    Norie Kurahashi
    Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Med Sci Monit 11:CR274-283. 2005
    b>Cryptorchidism is one of the most common congenital malformations in males...
  82. ncbi What is new in cryptorchidism and hypospadias--a critical review on the testicular dysgenesis hypothesis
    Jorgen Thorup
    Department of Pediatric Surgery, Faculty of Health Science, University of Copenhagen, Rigshospitalet, DK 2100 Copenhagen, Denmark
    J Pediatr Surg 45:2074-86. 2010
    ..In more than 95% of the cases, hypospadias is not associated with cryptorchidism, suggesting major differences in pathogenesis...
  83. pmc INSL3/RXFP2 signaling in testicular descent
    Shu Feng
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
    Ann N Y Acad Sci 1160:197-204. 2009
    Mutations of the insulin-like peptide 3 (INSL3) hormone or its receptor, RXFP2, cause intraabdominal cryptorchidism in male mice. Specific RXFP2 expression in mouse gubernacula was detected at embryonic day 14...
  84. ncbi Management of cryptorchism and risk of testicular cancer
    Lisa J Herrinton
    Division of Research, Kaiser Permanente, Oakland, CA 94612, USA
    Am J Epidemiol 157:602-5. 2003
    ..In contrast, all four of the early orchiopexies performed on the controls were successful. Boys with failed orchiopexy should be considered for reoperative orchiopexy or orchiectomy to prevent testicular cancer...
  85. ncbi Lack of LGR8 gene mutation in Finnish patients with a family history of cryptorchidism
    Jaesook Roh
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Reprod Biomed Online 7:400-6. 2003
    b>Cryptorchidism is the most frequent congenital anomaly of the urogenital tract in the male. Although in Western countries 1-2% of males at the age of 3 months are diagnosed with this condition, its aetiology is still unknown...
  86. pmc Germ cell apoptosis after treatment of cryptorchidism with human chorionic gonadotropin is associated with impaired reproductive function in the adult
    L Dunkel
    Children s Hospital, University of Helsinki, Finland
    J Clin Invest 100:2341-6. 1997
    b>Cryptorchidism results in impaired fertility. Reduced numbers of testicular germ cells can be shown histologically during the first years of life...
  87. ncbi Fertility after cryptorchidism: epidemiology and other outcome studies
    Peter A Lee
    Department of Pediatrics, Pennsylvania State College of Medicine, The Milton S Hershey Medical Center, Hershey, Pennsylvania, USA
    Urology 66:427-31. 2005
  88. ncbi Preliminary data suggest that mutations in the CgRP pathway are not involved in human sporadic cryptorchidism
    D Zuccarello
    Department of Molecular Medicine and Pathology, University La Sapienza, Rome, Italy
    J Endocrinol Invest 27:760-4. 2004
    In testicular descent to the scrotum, a multistep process, many anatomical and hormonal factors play a role. Cryptorchidism occurs in about 1-2% of males and may cause secondary degeneration of the testes...
  89. ncbi Hormonal treatment for unilateral inguinal testis: comparison of four different treatments
    S Bertelloni
    Endocrine Unit, Division of Paediatrics, Santa Chiara Hospital, University of Pisa, Italy
    Horm Res 55:236-9. 2001
    Hormonal treatment of cryptorchidism has been used since the 30s, but controversies persist on its efficacy. It is also unclear whether there are differences with the use of different hormonal trials.
  90. ncbi Age at orchiopexy and testis palpability predict germ and Leydig cell loss: clinical predictors of adverse histological features of cryptorchidism
    Gregory E Tasian
    Department of Urology, University of California San Francisco, San Francisco, California 94143 0738, USA
    J Urol 182:704-9. 2009
    We determined the relationship between clinical variables and testicular histopathological changes associated with decreased fertility potential in children with cryptorchidism.
  91. ncbi A missense mutation in LRR8 of RXFP2 is associated with cryptorchidism
    Rebecca M Harris
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Arthur J Rubloff Building, 420 E Superior St, Suite 12 109, Chicago, IL 60611, USA
    Mamm Genome 21:442-9. 2010
    Using genome-wide mutagenesis with N-ethyl-N-nitrosourea (ENU), a mouse mutant with cryptorchidism was identified...
  92. ncbi ESR1 promoter polymorphism is not associated with nonsyndromic cryptorchidism
    Deborah Lo Giacco
    Andrology Service, Molecular Biology Laboratory, Fundacio Puigvert, Universitat Autonoma de Barcelona, Barcelona, Spain
    Fertil Steril 95:369-71, 371.e1-2. 2011
    ..In a case-control study, we were unable to demonstrate any association between (TA)n and nonsyndromic cryptorchidism in Italian and Spanish study populations.
  93. pmc Risk factors for cryptorchism among populations at differing risks of testicular cancer
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA
    Int J Epidemiol 35:787-95. 2006
    ..However, while TGCT incidence varies greatly between white and black men, little variability has been reported between the two groups in cryptorchism prevalence. This may suggest that cryptorchism risk factors differ by ethnicity...
  94. ncbi Sperm count of young men surgically treated for cryptorchidism in the first and second year of life: fertility is better in children treated at a younger age
    F Canavese
    Department of Pediatric Surgery, Regina Margherita Children s Hospital, Piazza Polonia 94, Turin, Italy
    Eur J Pediatr Surg 19:388-91. 2009
    ..In this study, we evaluated testicular function in young men operated on for cryptorchidism in the first year of life. To our knowledge, this is the first report on the effects of such an early treatment...
  95. pmc Trends in the incidence of cryptorchidism and hypospadias of registry-based data in Korea: a comparison between industrialized areas of petrochemical estates and a non-industrialized area
    Sae Chul Kim
    Department of Urology, Chung Ang University College of Medicine, Seoul 156 756, Korea
    Asian J Androl 13:715-8. 2011
    This study aimed to represent the recent trends in the nationwide incidence of cryptorchidism and hypospadias in Korea, and to determine whether there is evidence of spatial heterogeneity in the incidence...
  96. ncbi Cryptorchidism: pathogenesis, diagnosis, treatment and prognosis
    Richard A Ashley
    Nemours Alfred I duPont Hospital for Children, Division of Pediatric Urology, Wilmington, DE 19803 3607, USA
    Urol Clin North Am 37:183-93. 2010
    b>Cryptorchidism is a common genital anomaly diagnosed at birth or during childhood...
  97. ncbi Nordic consensus on treatment of undescended testes
    E Martin Ritzen
    Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden
    Acta Paediatr 96:638-43. 2007
    ..To reach consensus among specialists from the Nordic countries on the present state-of-the-art in treatment of undescended testicles...
  98. ncbi Prospective study on the prevalence and associated risk factors of cryptorchidism in 6246 newborn boys from Nice area, France
    K Wagner-Mahler
    Pediatrics Department, CHU Nice, Nice, France Conseil Général Des Alpes Maritimes, Nice, France
    Int J Androl 34:e499-510. 2011
    To assess the incidence and risk factors of cryptorchidism in Nice area. A 3-year prospective study was conducted at two maternity wards involving neonatal screening of boys born ≥34weeks of amenorrhoea...
  99. ncbi Unilateral cryptorchidism in mice mutant for Ptgds
    Pascal Philibert
    Département d Hormonologie, Hopital Lapeyronie, CHU de Montpellier et Université Montpellier 1, Montpellier, France
    Hum Mutat 34:278-82. 2013
    The pathophysiology of cryptorchidism, abnormal testicular descent, remains poorly understood...
  100. ncbi Clinical, cytogenetic and molecular evaluation in a dog with bilateral cryptorchidism and hypospadias
    R Cassata
    Physiopathology and Reproduction, Faculty of Veterinary Medicine, University Federico II, Naples, Italy
    Cytogenet Genome Res 120:140-3. 2008
    The aim of this study was to estimate prognostic factors in a Dalmatian dog with bilateral cryptorchidism and hypospadias...
  101. ncbi Homeobox HOXA10 gene analysis in cryptorchidism
    Veronica Bertini
    Cytogenetic and Molecular Biology Unit, Santa Chiara Hospital, Pisa, Italy
    J Pediatr Endocrinol Metab 17:41-5. 2004
    In male mice, targeted disruption of the homeobox gene hoxa10 causes cryptorchidism and infertility. Genetic alterations in exon 1 of HOXA10 have been found in a high number of boys with cryptorchidism.

Research Grants54

  1. ORGANOCHLORINE PESTICIDES AND MALE GENITAL ANOMALIES
    Rajiv Bhatia; Fiscal Year: 2002
    ..The Investigators propose a nested case-control study of cryptorchidism and hypospadias and in utero exposure to DDT within the Child Health and Development Studies (CHDS) cohort...
  2. The Mechanism of Cryptorchidism in LH Receptor Knockout Animals
    Zhenmin Lei; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Cryptorchidism is by far the most common defect of sexual differentiation in humans. Testicular descent can be anatomically divided into two stages, i.e., transabdominal and inguinoscrotal phases...
  3. Phthalate Exposure and Pregnancy Outcome
    T Peter Stein; Fiscal Year: 2010
    ..duration together with the incidence of birth defects, particularly male urogenital defects including cryptorchidism and hypospadias...
  4. Epidemiology of testicular cancer in the Utah population
    Mia Hashibe; Fiscal Year: 2012
    ..The well-established testicular cancer risk factors include age, contralateral testicular cancer, cryptorchidism, race/ethnicity and family history of testicular cancer...
  5. Three-generation Human Study of Reproductive Effects of Marine Food Contaminants
    PHILIPPE ADAM GRANDJEAN; Fiscal Year: 2010
    ..The incidence of testicular cancer has increased and semen quality has decreased, and the incidences of cryptorchidism and hypospadias appear to have increased in certain regions...
  6. Phthalates in Drugs and Male Genital Malformation
    Allen A Mitchell; Fiscal Year: 2012
    ..Prenatal exposure of male rats to DBP and DEHP has been shown to produce cryptorchidism and hypospadias, presumably due to their anti-androgenic activity...
  7. Genetics and the Environment Associated with Male Reproduction (GEAR)
    Sheela Sathyanarayana; Fiscal Year: 2012
    ..provided by applicant): In specific areas of industrialized nations, the rising incidence of hypospadias and cryptorchidism from 1950- 2000 parallels the production and use of some phthalates, anti-androgenic synthetic chemicals used ..
  8. Disorders of Sex Development: Platform for Basic and Translational Research
    ERIC J VILAIN; Fiscal Year: 2013
    ..sex development (DSD) are phenotypically heterogeneous, ranging from minor genital malformations (hypospadias, cryptorchidism, hypertrophy of the clitoris) to genital ambiguity...
  9. Translational control during fetal male germ cell development
    CHRIS BENNETT GEYER; Fiscal Year: 2012
    ..dysgenesis syndrome, a spectrum of male reproductive disorders such as carcinoma in situ, testicular cancer, cryptorchidism, and hypospadia that originate during this fetal period of germ cell development...
  10. Molecular Mechanism of Human Fetal Testis Susceptibility to Endocrine Disruption
    Kim Boekelheide; Fiscal Year: 2013
    ..the observed abnormalities-including malformed external genitalia (hypospadias), undescended testis (cryptorchidism), spermatogenic defects, and testis germ cell cancer-result from alterations in the in utero and perinatal ..
  11. A Genetic Linkage Study of Testicular Cancer
    Victoria Cortessis; Fiscal Year: 2009
    ..risk factors are family history of testis cancer (relative risk of 10 for brothers) and a personal history of cryptorchidism or congenitally undescended testicles (relative risk 2.5-18)...
  12. Genetic Basis of Cryptorchidism
    Julia Spencer Barthold; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Cryptorchidism is a common congenital anomaly with evidence for multilocus genetic contribution...
  13. Gene Networks in Peri-pubertal Sertoli Cell Injury
    Mary L Hixon; Fiscal Year: 2010
    ..registry surveys demonstrate that altered intrauterine growth increases the risks of congenital hypospadias, cryptorchidism and testicular cancer approximately 2- to 3-fold...
  14. EPIDEMIOLOGY OF MALE INFERTILITY: CRYPTORCHIDISM
    Peter Lee; Fiscal Year: 1999
    b>Cryptorchidism is a major, but poorly studied, cause of male infertility...
  15. INFECTIOUS ETIOLOGY TESTICULAR CANCER
    Loren Lipworth; Fiscal Year: 2000
    The trend of increasing testicular cancer incidence is unlikely to be explained by known risk factors such as cryptorchidism. An infectious etiology of testicular cancer has been proposed, based on similarities between the age-specific ..
  16. REGULATION OF TESTICULAR BLOOD FLOW
    Claude Desjardins; Fiscal Year: 1993
    ..reproductive health because it provides a framework for investigating the unknown etiology of testicular vascular disorders (varicocele, orchitis, and cryptorchidism), the most prominent source of testicular dysfunction and infertility.
  17. Murine Atlas of Genitourinary Smooth Muscle Development
    JAMES LESSARD; Fiscal Year: 2009
    ..e. hypospadias and cryptorchidism) are increasing...
  18. PHTHALATE-INDUCED MURINE TESTICULAR DYSGENESIS AND P53
    Kim Boekelheide; Fiscal Year: 2007
    ..the observed abnormalities-including malformed external genitalia (hypospadias), undesecended testis (cryptorchidism), spermatogenic defects, and testis germ cell cancer- result from the alterations in the in utero and ..
  19. Insulin-3 in Human Testicular Disease and as a Therapeutic Agent
    Linda Baker; Fiscal Year: 2009
    ..This is likely due to abnormal testicular development. In addition, cryptorchidism, the absence of the testicle from the scrotum, is the most common genital anomaly of male infants affecting 3% ..
  20. PREVALENCE & EPIDEMIOLOGY OF CRYPTORCHIDISM
    Gertrud Berkowitz; Fiscal Year: 1991
    The overall objectives of this proposal are to determine the prevalence rate of true cryptorchidism during early infancy and to assess the role of maternal and gestational factors in the epidemiology of cryptorchidism...
  21. Molecular Mechanisms of Wnt4 Action in Developing Gonad
    Alice Fleming; Fiscal Year: 2006
    ..Male patients with duplications in Wnt4 exhibit sexual phenotypes ranging from cryptorchidism to XY sex reversal...
  22. DIETHYLSTILBESTROL AND TESTICULAR CANCER IN CONNECTICUT
    John Lewis; Fiscal Year: 1980
    ..Drug histories will be obtained from hospital records and from prenatal records of mothers. Other factors to be evaluated include exposure to other exogenous estrogens in utero, cryptorchidism, and hypoplastic testes.
  23. Biological Role of a Novel Testis Insulin-Like Protein
    Ram Menon; Fiscal Year: 2004
    ..Furthermore, the recent discovery of the cognate receptor (LGR8) for Insl3 and the elucidation of cryptorchidism as one of components of the LGR8 null phenotype underscore the exciting advances made in this field...
  24. MOLECULAR EPIDEMIOLOGY OF TESTICULAR CARCINOMA
    Stephen Schwartz; Fiscal Year: 2009
    ..The findings from this study will add new information regarding the epidemiology and etiology of TGCC, and will serve as a resource for future investigations of the interplay of genetic and non-genetic factors in these malignancies. ..
  25. PREVENTIVE ONCOLOGY ACADEMIC AWARDS
    Lisa Herrinton; Fiscal Year: 2000
    ..Does surgical correction of cryptorchidism (orchidopexy) at a relatively young age reduce the risk of germ-cell testicular cancer to a greater extent ..
  26. Fetal Basis of Sexual Dysfunction: Brain Differentiation
    D N Rao Veeramachaneni; Fiscal Year: 2007
    ..By using a relevant and yet practical animal model the proposed studies will advance the knowledge base in pollutant-induced sexual/erectile dysfunction, an area pivotal to reproductive health/success in humans. [unreadable] [unreadable]..
  27. Mechanisms Causing Cryptorchidism and Fetal Transformation of Testicular Cells
    D N Rao Veeramachaneni; Fiscal Year: 2007
    ..Our long-term goal is to delineate molecular mechanisms underlying cryptorchidism and transformation of testicular cells into precancerous cells...
  28. Mechanisms of Growth Factor-Estrogen Receptor Crosstalk
    Stephen Safe; Fiscal Year: 2006
    ..abstract_text> ..
  29. ALKYL PCDFS--INHIBITION OF MAMMARY CANCER
    Stephen Safe; Fiscal Year: 2001
    ..Thus the proposed studies will define a new mechanism-based class of antiestrogens that can be used alone or in combination with tamoxifen for treatment of breast and endometrial cancer. ..
  30. Colon Cancer Inhibition by a Class of PPARgamma Agonists
    Stephen Safe; Fiscal Year: 2009
    ..The proposed studies will provide mechanistic insights on PPARy-dependent inhibition of colon cancer and identify compounds for future clinical studies. ..
  31. ESTROGEN INDUCED RESPONSES VIA ER/SPL COMPLEXES
    Stephen Safe; Fiscal Year: 2002
    ..These results will ultimately facilitate design of chemotherapeutic approaches which target specific genes. ..
  32. Coactivation of Estrogen Receptor alpha/Sp1
    Stephen Safe; Fiscal Year: 2006
    ..abstract_text> ..
  33. TOXICOLOGY OF ENVIRONMENT CONTAMINANTS
    Stephen Safe; Fiscal Year: 2007
    ..The proposed training program will continue to provide trainees with a challenging academic and research environment that will prepare them for future careers in academic, industry and government. ..
  34. Inhibition of Pancreatic Cancer by New PPARgamma Agonis*
    Stephen Safe; Fiscal Year: 2008
    ..PPAR? -active C-substituted DIMs that inhibit pancreatic cancer cell growth in vitro and in vivo, and these will serve as lead compounds for development of new drugs for clinical treatment of this devastating disease ..
  35. AUTOSOMAL MECHANISMS OF TESTIS INDUCTION
    VICKI MEYERS WALLEN; Fiscal Year: 2005
    ..At the end of this grant period, we will have identified the gene causing this disorder and the step in the testis pathway that is altered by the mutation in timing, quantity, or location of gene expression. ..
  36. 2,3,7,8,--TCDD Effects on the Estrogenic Responses
    Stephen Safe; Fiscal Year: 2006
    ..The proposed Aims will address important mechanistic considerations on IDRE-independent inhibitory AhR-ERa crosstalk and pathways critical for inhibition of mammary tumor growth by SAhRMs. ..
  37. Immunity to brain Ma proteins: A remote effect of cancer
    Josep Dalmau; Fiscal Year: 2007
    ..abstract_text> ..
  38. Comparative Effectiveness of Treatments for Localized Prostate Cancer
    David F Penson; Fiscal Year: 2010
    ..By figuring out what treatments "work best, in which patients and in whose hands", we will help men with prostate cancer make better decisions regarding their care. ..
  39. A Preclinical Model of Adolescent Toluene Abuse in Rats
    Scott Bowen; Fiscal Year: 2005
    ..The model also has the potential to assist in devising effective treatments and prevention strategies for adolescent inhalant abuse. ..
  40. Self-administration of abused inhalants in mice
    Scott Bowen; Fiscal Year: 2004
    ....
  41. Testicular Torsion: Mechanisms and Treatment
    Terry Turner; Fiscal Year: 2005
    ..It is likely that these investigations will be relevant to other forms of oxidative stress inducing testicular dysfunction. ..
  42. RELAXIN-LIKE FACTOR IN MALE GONADAL DEVELOPMENT
    Christian Schwabe; Fiscal Year: 2005
    ..the role RLF is playing in these processes and will significantly improve the prospects for a drug to treat cryptorchidism. We intend to use specially designed synthetic RLF derivatives and anti-RLF antibodies to study the process of ..
  43. Modulation of Insulin Action by Testosterone in Men
    Nelly Pitteloud; Fiscal Year: 2010
    ..Therefore, if low T levels are shown to play a role in the pathogenesis of insulin resistance, T may well represent an important therapeutic modality for both preventing and treating the metabolic syndrome and type 2 diabetes in men. ..
  44. Aging and Function of Stem Leyding Cells
    Ren Shan Ge; Fiscal Year: 2010
    ....
  45. Dietary Glycemic Load, Obesity, and Birth Defect Risks
    Martha Werler; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  46. The Role of Hormone Polymorphisms in Menstrual Function and Fertility
    CHANLEY SMALL; Fiscal Year: 2008
    ..The proposed pilot study is an efficient use of existing data and biological specimens to explore these relationships among a subset of important genes in reproductive function. [unreadable] [unreadable] [unreadable]..
  47. Race, Comorbidity & Long Term Prostate Cancer Outcomes
    David Penson; Fiscal Year: 2009
    ..Specifically, it will help newly-diagnosed patients make more informed decisions regarding treatment and will help researchers design novel interventions to improve the quality of life of prostate cancer survivors. ..
  48. New York State Angler Cohort Follow-up Study
    Matthew Bonner; Fiscal Year: 2009
    ..abstract_text> ..
  49. Targeting Relaxin Signaling in Prostate Cancer
    Alexander Agoulnik; Fiscal Year: 2008
    ..Demonstartion of the anti- tumor activity of RLN signaling supression may provide a novel target for therapeutical intervention in this deadly disease. ..
  50. Paraneoplastic Disorders of CNS: Autoantigen Profiling
    Josep Dalmau; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  51. Longterm Quality of Life of Prostate Cancer Survivors
    David Penson; Fiscal Year: 2006
    ..This, in turn, will aid in clinical decision making and assist in designing interventions to improve outcomes in prostate cancer survivors. ..
  52. Maternal Vasoactive Exposures and Risk of Clubfoot
    Martha M Werler; Fiscal Year: 2010
    ..Buccal cell swabs will be collected from cases, controls, and their mothers. DNA will be extracted and stored for the purpose of studying genetic risk factors in future studies. ..
  53. Behavioral Effects of Gestational Inhalant Abuse in Rats
    Scott Bowen; Fiscal Year: 2006
    ..Finally, this research has the potential to assist in the design of effective treatments for inhalant abuse. [unreadable] [unreadable]..
  54. Calorie Restriction Effects on Chromosomal Aberrations
    CHARLEEN MOORE; Fiscal Year: 2003
    ..The results will be essential in identifying potential mechanisms by which CR acts in cancer prevention and delay of the aging process in long-lived species such as the rhesus monkey and humans. ..