spermatic cord torsion

Summary

Summary: Torsion of the spermatic cord caused usually by incomplete attachment of the epididymis to the testis or by inclusion of the cord within the tunica vaginalis. Faulty development of various anatomical components of the testes is also a cause. It occurs most frequently in childhood and adolescence. (From Current Medical Information & Terminology, 5th ed)

Top Publications

  1. ncbi Protective effects of sildenafil administration on testicular torsion/detorsion damage in rats
    Azadeh Beheshtian
    Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, PO Box 13145 784, Tehran, Iran
    World J Urol 26:197-202. 2008
  2. ncbi Spermatic cord torsion, reactive oxygen and nitrogen species and ischemia-reperfusion injury
    Danilo Wilhelm Filho
    Departamento de Ecologia e Zoologia, Universidade Federal de Santa Catarina, Cidade Universitaria, Catarina, Trindade, 88040 900 Florianopolis, SC, Brazil
    Mol Aspects Med 25:199-210. 2004
  3. ncbi Testicular function after torsion of the spermatic cord
    A J Visser
    Department of Urology, University of Stellenbosch and Tygerberg Hospital, Cape Town, South Africa
    BJU Int 92:200-3. 2003
  4. ncbi Protective effects of Ginkgo biloba (EGb 761) on testicular torsion/detorsion-induced ischemia-reperfusion injury in rats
    Mehmet Kanter
    Department of Histology and Embryology, Faculty of Medicine, University of Trakya, Edirne, Turkey
    Exp Mol Pathol 91:708-13. 2011
  5. ncbi Familial testicular torsion
    Jimena Cubillos
    Divisions of Pediatric Urology, Cohen Children s Medical Center of New York of North Shore Long Island Jewish Health System, New Hyde Park, NY, USA
    J Urol 185:2469-72. 2011
  6. ncbi Molecular pathway of germ cell apoptosis following ischemia/reperfusion of the rat testis
    J J Lysiak
    Departments of Urology and Cell Biology, The University of Virginia Health Science Center, Charlottesville, Virginia 22908, USA
    Biol Reprod 63:1465-72. 2000
  7. ncbi Caspase-9-dependent pathway to murine germ cell apoptosis: mediation by oxidative stress, BAX, and caspase 2
    Jeffrey J Lysiak
    Department of Urology, University of Virginia Health Science System, Charlottesville, VA 22908, USA
    Cell Tissue Res 328:411-9. 2007
  8. ncbi Perinatal testicular torsion: a unique strategy
    José L Cuervo
    Neonatal Unit Sanatorio Otamendi, Buenos Aires 1425, Argentina
    J Pediatr Surg 42:699-703. 2007
  9. ncbi Stimulation of hypoxia-inducible factor-1 alpha (HIF-1alpha) protein in the adult rat testis following ischemic injury occurs without an increase in HIF-1alpha messenger RNA expression
    John D Powell
    Biology Department, Monmouth University, West Long Branch, New Jersey 07764, USA
    Biol Reprod 67:995-1002. 2002
  10. ncbi Fluctuations in rat testicular interstitial oxygen tensions are linked to testicular vasomotion: persistence after repair of torsion
    J J Lysiak
    Departments of Urology and Cell Biology, University of Virginia Health Science Center, Charlottesville, Virginia 22908, USA
    Biol Reprod 63:1383-9. 2000

Research Grants

  1. Testicular Torsion: Mechanisms and Treatment
    Terry Turner; Fiscal Year: 2005
  2. Sertoli Cell Mediated Engulfment of Apoptotic Germ Cells
    Kodi S Ravichandran; Fiscal Year: 2010
  3. Hypoxia and the Role of HIF-1 in the Ischemic Testis
    Michael Palladino; Fiscal Year: 2005

Detail Information

Publications170 found, 100 shown here

  1. ncbi Protective effects of sildenafil administration on testicular torsion/detorsion damage in rats
    Azadeh Beheshtian
    Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, PO Box 13145 784, Tehran, Iran
    World J Urol 26:197-202. 2008
    ..We assessed the effectiveness of sildenafil administration during ischemic period in a rat model of testicular torsion/detorsion (T/D)...
  2. ncbi Spermatic cord torsion, reactive oxygen and nitrogen species and ischemia-reperfusion injury
    Danilo Wilhelm Filho
    Departamento de Ecologia e Zoologia, Universidade Federal de Santa Catarina, Cidade Universitaria, Catarina, Trindade, 88040 900 Florianopolis, SC, Brazil
    Mol Aspects Med 25:199-210. 2004
    ..more investigations on the molecular mechanisms and the antioxidant status in testis are necessary to ascertain the contribution of ROS to the tissue damage produced by spermatic cord torsion in experimental animals and humans.
  3. ncbi Testicular function after torsion of the spermatic cord
    A J Visser
    Department of Urology, University of Stellenbosch and Tygerberg Hospital, Cape Town, South Africa
    BJU Int 92:200-3. 2003
  4. ncbi Protective effects of Ginkgo biloba (EGb 761) on testicular torsion/detorsion-induced ischemia-reperfusion injury in rats
    Mehmet Kanter
    Department of Histology and Embryology, Faculty of Medicine, University of Trakya, Edirne, Turkey
    Exp Mol Pathol 91:708-13. 2011
    ..We believe that further preclinical research into the utility of EGb 761 may indicate its usefulness as a potential treatment on testes injury after I/R in rats...
  5. ncbi Familial testicular torsion
    Jimena Cubillos
    Divisions of Pediatric Urology, Cohen Children s Medical Center of New York of North Shore Long Island Jewish Health System, New Hyde Park, NY, USA
    J Urol 185:2469-72. 2011
    ..We present what is to our knowledge the largest series of familial torsion, including the first 3 generation case and a review of the literature...
  6. ncbi Molecular pathway of germ cell apoptosis following ischemia/reperfusion of the rat testis
    J J Lysiak
    Departments of Urology and Cell Biology, The University of Virginia Health Science Center, Charlottesville, Virginia 22908, USA
    Biol Reprod 63:1465-72. 2000
    ..Results suggest that germ cell apoptosis following ischemia/reperfusion of the rat testis is initiated through the mitochondria-associated molecule Bax as well as Fas-FasL interactions...
  7. ncbi Caspase-9-dependent pathway to murine germ cell apoptosis: mediation by oxidative stress, BAX, and caspase 2
    Jeffrey J Lysiak
    Department of Urology, University of Virginia Health Science System, Charlottesville, VA 22908, USA
    Cell Tissue Res 328:411-9. 2007
    ....
  8. ncbi Perinatal testicular torsion: a unique strategy
    José L Cuervo
    Neonatal Unit Sanatorio Otamendi, Buenos Aires 1425, Argentina
    J Pediatr Surg 42:699-703. 2007
    ..The aim of this study was to evaluate the data obtained from patients with PTT and propose principles of management based on clinical, surgical, and histologic findings...
  9. ncbi Stimulation of hypoxia-inducible factor-1 alpha (HIF-1alpha) protein in the adult rat testis following ischemic injury occurs without an increase in HIF-1alpha messenger RNA expression
    John D Powell
    Biology Department, Monmouth University, West Long Branch, New Jersey 07764, USA
    Biol Reprod 67:995-1002. 2002
    ..HIF-1alpha protein was also elevated by experimental torsion and reperfusion compared with normoxic controls. These results support the hypothesis that HIF-1 may play a role in the cellular response to hypoxia in the ischemic testis...
  10. ncbi Fluctuations in rat testicular interstitial oxygen tensions are linked to testicular vasomotion: persistence after repair of torsion
    J J Lysiak
    Departments of Urology and Cell Biology, University of Virginia Health Science Center, Charlottesville, Virginia 22908, USA
    Biol Reprod 63:1383-9. 2000
    ..These results demonstrate for the first time a correlation between testicular vasomotion and interstitial PO(2) cycling, and this correlation persists after the repair of testicular torsion...
  11. ncbi Experimental testicular torsion: reperfusion blood flow and subsequent testicular venous plasma testosterone concentrations
    Terry T Turner
    Department of Urology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Urology 65:390-4. 2005
    ....
  12. ncbi The effects of N-acetylcysteine on testicular damage in experimental testicular ischemia/reperfusion injury
    Binhan Kagan Aktas
    Department of Urology, Numune Education and Research Hospital, Cevizlidere Mah 14 Cad, Balgat 12 25, 06100 Ankara, Turkey
    Pediatr Surg Int 26:293-8. 2010
    ..The aim of this study to evaluate the effects of N-acetylcysteine (NAC) on testicular damage in a rat testicular ischemia-reperfusion (I/R) injury model...
  13. ncbi Ipsilateral testicular necrosis and atrophy after 1,080-degree torsion of the spermatic cord in rats
    Frederico Ramalho Romero
    UFPR, Curitiba PR, Brazil
    Acta Cir Bras 24:118-23. 2009
    ..To assess the incidence of testicular necrosis/atrophy immediately after 1 to 4 hours of 1,080-degree torsion of the spermatic cord, and 60 days after detorsion of the spermatic cord...
  14. ncbi Nitric oxide promotes germ cell necrosis in the delayed phase after experimental testicular torsion of rat
    K Shiraishi
    Department of Urology, Yamaguchi University School of Medicine, Ube, Yamaguchi 755 8505, Japan
    Biol Reprod 65:514-21. 2001
    ..Inducible NOS inhibition combined with calpain inhibition may improve impaired spermatogenesis after testicular torsion...
  15. ncbi Testicular torsion
    Erika Ringdahl
    Department of Family and Community Medicine, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212, USA
    Am Fam Physician 74:1739-43. 2006
    ..Surgical treatment of torsion of the appendix testis is not mandatory but hastens recovery...
  16. ncbi The morphological evaluation of ipsilateral and contralateral vasa deferentia in a rat model of unilateral spermatic cord torsion
    Arzu Pampal
    Department of Pediatric Surgery, Faculty of Medicine, Ufuk University, Ankara, Turkey
    Pediatr Surg Int 26:287-92. 2010
    b>Spermatic cord torsion is a surgical emergency that requires early intervention to protect the effected testicle...
  17. ncbi The molecular pathology of experimental testicular torsion suggests adjunct therapy to surgical repair
    Terry T Turner
    Departments of Urology and Cell Biology, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    J Urol 172:2574-8. 2004
    ..Evidence from animal models is used to discover pathways that might be amenable to manipulation by therapeutic regimens...
  18. ncbi Spermatic cord torsion with preserved testis perfusion: initial anatomical observations
    Dennis F Bentley
    Department of Urology, Northeastern Ohio Universities College of Medicine, Akron, Ohio, USA
    J Urol 172:2373-6. 2004
    ..We hypothesize that patients with specific anatomical configurations maintain testicular blood flow for prolonged periods, and, therefore, will have flow on ultrasound despite concurrent torsion...
  19. ncbi Glucocorticoid hormone can suppress apoptosis of rat testicular germ cells induced by testicular ischemia
    H Yazawa
    Yamagata University School of Medicine, Yamagata, Japan
    Fertil Steril 75:980-5. 2001
    ..This inhibition was suppressed by intravenous injection of mifepristone, a glucocorticoid-receptor antagonist. CONCLUSION(S): Glucocorticoids can be administered for torsion in addition to conventional torsion repair...
  20. ncbi Original report. Testicular torsion in neonates and infants: sonographic features in 30 patients
    Jeffrey Traubici
    Department of Diagnostic Imaging, The Hospital for Sick Children, University of Toronto, 555 University Ave, Toronto, Ontario M5G 1X8, Canada
    AJR Am J Roentgenol 180:1143-5. 2003
    ..The purpose of this study was to illustrate the spectrum of sonographic findings in testicular torsion in a large series of neonates and infants. These patterns and their evolution have, to our knowledge, not been described previously...
  21. ncbi Protective role of erythropoietin during testicular torsion of the rats
    Nuray Yazihan
    Pathophysiology Department, Faculty of Medicine, Ankara University, Ankara, Turkey
    World J Urol 25:531-6. 2007
    ..We conclude that testicular I/R causes an increase in germ cell apoptosis both in the ipsilateral and contralateral testes. Erythropoietin has antiapoptotic and anti-inflammatory effects following testicular torsion...
  22. ncbi [Effect of allopurinol on rat testicles morphology, submitted to ischaemia for spermatic cord torsion followed by reperfusion]
    Andréia C M Brochado Antoniolli Silva
    Universidade Federal de Sao Paulo, Escola Paulista de Medicina
    Acta Cir Bras 20:468-72. 2005
    ..In this investigation has been studied the effect of the allopurinol on the reperfusion injury phenomenon in testicles of rats...
  23. ncbi Prenatal testicular torsion: diagnosis and natural course. An ultrasonographic study
    Jan Willem van der Sluijs
    Department of Pediatric Radiology, Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Eur Radiol 14:250-5. 2004
    ..In newborns with a scrotal mass, these ultrasonographic findings should suggest this diagnosis and delay in immediate surgery and/or oncological work-up may be appropriate...
  24. ncbi Propofol attenuates reperfusion injury after testicular torsion and detorsion
    Ali Unsal
    Department of Urology, Fatih University, P K 5, Emek 06510, Ankara, Turkey
    World J Urol 22:461-5. 2004
    ..Preference of propofol for anaesthesia during the detorsion procedure may attenuate such reperfusion injury...
  25. ncbi Gradual detorsion of torsioned rat testis attenuates ischemia reperfusion injury
    Bulent Akcora
    Department of Pediatric Surgery, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey
    J Pediatr Surg 43:1879-84. 2008
    ..This study was designed to investigate effect of gradual detorsion on testicular ischemia reperfusion injury...
  26. ncbi Protective effects of immunophilin ligands on testicular torsion/detorsion damage in rats
    Behtash Ghazi Nezami
    Basic Medical Sciences Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Int Urol Nephrol 41:93-9. 2009
    ..The purpose was to investigate the role of immunophilin ligands in ischemia/reperfusion (I/R)-induced germ cell apoptosis in the rat...
  27. ncbi Protective effect of trapidil on long-term histologic damage in a rat model of testicular ischemia-reperfusion injury
    Murat Bozlu
    Department of Urology, University of Mersin School of Medicine, Zeytinlibahce Caddesi, 33079, Mersin, Turkey
    World J Urol 27:117-22. 2009
    ..In recent years, it has been used successfully to decrease ischemia-reperfusion injury in several organ systems. We evaluated the effect of trapidil on the long-term histologic damage in testicular ischemia-reperfusion injury...
  28. ncbi Vardenafil reduces testicular damage following ischemia/reperfusion injury in rats
    Bulent Erol
    Department of Urology, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak, Turkey
    Kaohsiung J Med Sci 25:374-80. 2009
    ..Administration of 1 mg/kg vardenafil during testicular torsion decreased ischemia/reperfusion cellular damage. Our results indicate that the reduction in oxidative stress by vardenafil may play a major role in its cytoprotective effects...
  29. ncbi Is an empty left hemiscrotum and hypertrophied right descended testis predictive of perinatal torsion?
    A Barry Belman
    Division of Pediatric Urology, Children s National Medical Center, and Department of Urology and Pediatrics, George Washington University Medical School, Washington, DC, USA
    J Urol 170:1674-5; discussion 1675-6. 2003
    ..We determine whether the finding of a nonpalpable left testis and hypertrophied(2 cc or greater) right testis is predictive of an atrophic (perinatal torsion) left testis...
  30. ncbi Management of perinatal torsion: today, tomorrow or never?
    Elizabeth B Yerkes
    Department of Urology, Wilford Hall Medical Center, Lackland AFB, Lackland, Texas, USA
    J Urol 174:1579-82; discussion 1582-3. 2005
    ..Risk of general anesthesia must be weighed against the risk of anorchia. We describe our collective experience with bilateral perinatal torsion, solidifying our recommendation for early exploration in all cases of perinatal torsion...
  31. ncbi Early exploration in perinatal torsion of the spermatic cord: a case report
    G Sakellaris
    Department of Pediatric Surgery, University of Crete, Heraklion, Greece
    J Matern Fetal Neonatal Med 15:207-9. 2004
    ..We report a case that was treated by immediate surgical intervention...
  32. ncbi Effect of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on apoptotic changes in contralateral testis following unilateral testicular torsion
    Gokhan Gokce
    Urology, Cumhuriyet University, Sivas, 58140, Turkey
    Int Urol Nephrol 40:989-95. 2008
    ....
  33. ncbi Ethyl pyruvate reduces germ cell-specific apoptosis and oxidative stress in rat model of testicular torsion/detorsion
    Seyedmehdi Payabvash
    Department of Pharmacology, School of Medicine, Medical Sciences Tehran University, Tehran 13145, Iran
    J Pediatr Surg 43:705-12. 2008
    ..We investigated the protective effects of ethyl pyruvate (EP) against testis tissue damage in an experimental model of testicular torsion...
  34. ncbi Hemin induced heme oxygenase-1 over expression involves nuclear factor-E2 related factor-2, nuclear factor-kappaB and extracellular regulated kinase: an experimental study in a testicular torsion-detorsion rodent model
    Stone Yang
    Department of Urology, Mackay Memorial Hospital, Taipei, Taiwan
    J Urol 179:2456-63. 2008
    ..In this study we elucidated which of these enzymes is involved in hemin induced heme oxygenase-1 over expression in testicular tissues after torsion-detorsion injury...
  35. ncbi Perinatal testicular torsion: preoperative radiological findings and the argument for urgent surgical exploration
    Sally J Ahmed
    University of California, San Diego, USA
    J Pediatr Surg 43:1563-5. 2008
    ..These cases illustrate that contralateral perinatal torsion may be present even when physical exam findings suggest unilateral involvement...
  36. ncbi Prenatal testicular torsion: ultrasonographic features, management and histopathological findings
    Francesco Arena
    Department of Medical and Surgical Pediatric Surgery, University of Messina, Italy
    Int J Urol 13:135-41. 2006
    ..To highlight the ultrasonographic features of prenatal torsion of the testis in utero (IUTT) at presentation, the neonatal management and the histological findings postorchiectomy or biopsy...
  37. ncbi Involvement of the bax and bcl-2 system in the induction of germ cell apoptosis is correlated with the time of reperfusion after testicular ischemia in a rat model
    Igor Sukhotnik
    Department of Pediatric Surgery, Bnai Zion Medical Center, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Fertil Steril 92:1466-9. 2009
    ....
  38. ncbi Bilateral torsion of the testicles in a newborn
    E Mouritsen
    Department of Pediatrics, Herning Central Hospital, Denmark
    Arch Gynecol Obstet 266:118. 2002
    ..We describe a case of bilateral torsion of the testes in a full term neonate...
  39. ncbi Spin on perinatal testicular torsion
    Naeem Samnakay
    Department of Paediatric Surgery, Mater Children s Hospital, South Brisbane, Queensland, Australia
    J Paediatr Child Health 42:734-6. 2006
    ..A good understanding of the issues unique to perinatal torsion will facilitate appropriate counseling of parents of affected neonates...
  40. ncbi The protective role of heme oxygenase-1 induction on testicular tissues after testicular torsion and detorsion
    Stone Yang
    Department of Urology, Mackay Memorial Hospital, Mackay Medicine, Management and Nursing College, Taipei, Taiwan, Republic of China
    J Urol 177:1928-33. 2007
    ..Testicular torsion-detorsion has been identified as an ischemia-reperfusion type of injury. We elucidated the protective role of heme oxygenase-1 super induction on testicular torsion-detorsion injury...
  41. ncbi Protective effect of rutin on testicular ischemia-reperfusion injury
    Si Ming Wei
    Department of Surgery, Zhejiang Medical College, Hangzhou City, Zhejiang Province, 310053, China
    J Pediatr Surg 46:1419-24. 2011
    ..This study aimed to investigate the effect of rutin, a well-known antioxidant, on testicular ischemia-reperfusion injury...
  42. pmc Asynchronous bilateral torsion of the spermatic cord in the newborn: a case report
    Sang Don Lee
    Department of Urology, Pusan National University Hospital, Busan, Korea
    J Korean Med Sci 17:712-4. 2002
    ..To our knowledge, the present case is the 6th case of asynchronous bilateral torsion of the spermatic cord in the English literature, and the first case in Korea...
  43. ncbi Prenatal testicular torsion: sonographic appearance in the newborn infant
    P Ricci
    Department of Radiology, Policlinico Umberto I, University of Rome La Sapienza, V le Regina Elena, 324, 00161 Rome, Italy
    Eur Radiol 11:2589-92. 2001
    The prenatal diagnosis of spermatic cord torsion is often really difficult and the diagnosis is usually retrospective. Herein, we report a case of a male newborn baby who presented at delivery with an enlarged, swollen and tender scrotum...
  44. ncbi Peptide and nonpeptide reactive oxygen scavengers provide partial rescue of the testis after torsion
    Jeffrey J Lysiak
    Department of Urology, University of Virginia Health Science System, Charlottesville 22908, USA
    J Androl 23:400-9. 2002
    ..The mechanism by which ROS modulates neutrophil adhesion to venules is presently under investigation, as are additional therapeutic regimens to block oxidative stress...
  45. ncbi [Effects of endothelial progenitor cells on spermatogenic functions in testicular detorsion in rats]
    Pu Cao
    Department of Surgery, School of Medicine, Southeast University, Nanjing 210009, China
    Zhonghua Yi Xue Za Zhi 91:2135-8. 2011
    ..To investigate the effects of transplanted endothelial progenitor cells (EPCs) on the spermatogenic functions in testicular detorsion...
  46. ncbi Is the vanished testis always a scrotal event?
    A B Belman
    Department of Urology, Children s National Medical Center, Washington, DC, USA
    BJU Int 87:480-3. 2001
    ..To determine if perinatal testicular torsion resulting in a vanished testis is an event that primarily occurs in the scrotum...
  47. ncbi Acute testicular ischemia results in germ cell-specific apoptosis in the rat
    T T Turner
    Department of Urology, University of Virginia School of Medicine, Charlottesville 22908, USA
    Biol Reprod 57:1267-74. 1997
    ..These events were contemporaneous with the first appearance of apoptosis and consistent with the hypothesis that post-torsion, germ cell-specific apoptosis is induced by reactive oxygen species...
  48. ncbi Protective effects of trapidil in ischemia-reperfusion injury due to testicular torsion and detorsion: an experimental study
    Salih Somuncu
    Department of Pediatric Surgery, School of Medicine, Kirikkale University, Kirikkale, Turkey
    Int J Urol 13:601-5. 2006
    ..We aimed to detect the preventive effects of trapidil in ischemia-reperfusion (IR) injury due to testicular torsion and detorsion...
  49. ncbi Perinatal extravaginal torsion of the testis in the first month of life is a salvageable event
    Mathew D Sorensen
    Department of Urology, University of Colorado Health Sciences Center, Denver, Colorado 80218, USA
    Urology 62:132-4. 2003
    ..To determine the effectiveness of immediate surgical exploration in salvaging perinatal testicular torsion...
  50. ncbi Neonatal testicular torsion--a lost cause?
    Cheri Mathews John
    Department of Paediatrics, Royal Liverpool Children s Hospital, Liverpool, United Kingdom
    Acta Paediatr 97:502-4. 2008
    ..Sixteen babies had contralateral orchidopexy. Doppler ultrasound scans were reported as normal in 2 of 13 babies who had scans. No testes were salvaged following surgery...
  51. ncbi Neonatal bilateral testicular torsion: a plea for emergency exploration
    Maciej Baglaj
    Department of Paediatric Surgery, Royal Hospital for Sick Children, Glasgow, Scotland
    J Urol 177:2296-9. 2007
    ..We performed a retrospective analysis of our experience in the management of bilateral perinatal torsion as well as a collective review of the medical literature...
  52. ncbi Neonatal torsion: a 14-year experience and proposed algorithm for management
    Jonathan D Kaye
    Division of Pediatric Urology, Schneider Children s Hospital of the North Shore Long Island Jewish Health System, New Hyde Park, New York, USA
    J Urol 179:2377-83. 2008
    ..We reviewed a large series of such cases and stratified neonatal torsion based on time of presentation to determine the potential for testicular salvage. To our knowledge this is the largest series of its kind in the literature...
  53. ncbi The effect of methylene blue on histological damage after spermatic cord torsion in a rat model
    A Greenstein
    Department of Urology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    BJU Int 88:90-2. 2001
    To investigate, in a rat model, whether methylene blue (a free-radical scavenger) is effective in alleviating the histological testicular damage caused by reperfusion after spermatic cord torsion.
  54. ncbi The effect of caffeic acid phenethyl ester (CAPE) on histopathological changes in testicular ischemia-reperfusion injury
    Esin Atik
    Department of Pathology, Mustafa Kemal University, Faculty of Medicine, Antakya, Hatay, Turkey
    Pharmacol Res 54:293-7. 2006
    ..At the same time testis tissue showed a decrease in iNOS activity. Our results suggest that CAPE treatment have a protective role on testicular T/D and this effect may be due to inhibiting the neutrophil mediated cellular injury...
  55. ncbi Electro-orchidogram: a non-invasive diagnostic tool in testicular pathologies
    Ahmed Shafik
    Department of Surgery and Experimental Research, Faculty of Medicine, Cairo University, Cairo, Egypt
    Med Sci Monit 12:MT51-5. 2006
    ..We investigated the hypothesis that the transcutaneous electro-orchidogram (EOG) can act as a diagnostic tool in testicular pathological conditions...
  56. ncbi Acute scrotal pain in children--ten years' experience
    J Varga
    Pediatric Surgery Clinic Novi Sad, Novi Sad, Serbia and Montenegro
    Urol Int 78:73-7. 2007
    ..The aim of this study was to analyze the incidence, symptomatology and results of treatment of acute scrotal pain in children...
  57. ncbi Sonography of the acute scrotum: the four T's of testicular imaging
    Aaron F Wittenberg
    Department of Radiology, MetroHealth Medical Center, Cleveland, OH 44118, USA
    Curr Probl Diagn Radiol 35:12-21. 2006
    ..Images demonstrating the sonographic and color Doppler appearances of each of the "four T's" will be reviewed. The radiographic review will focus on the imaging features, which are the keys to arriving at the correct diagnosis...
  58. ncbi Effect of external scrotal cooling on the viability of the testis with torsion in rats
    M Haj
    Department of Surgery, Western Galilee Hospital, Nahariya, Israel
    Eur Surg Res 39:160-9. 2007
    ..Our aim is to evaluate the effect of external scrotal cooling in preserving testicular viability after spermatic cord torsion in rats.
  59. ncbi The painful scrotum: an ultrasonographical approach to diagnosis
    M Muttarak
    Department of Radiology, Chiang Mai University, 110 Intavaroros Road, Chiang Mai 50200, Thailand
    Singapore Med J 46:352-7; quiz 358. 2005
    ..This pictorial essay is intended to review the causes, US appearances of disease processes causing the painful scrotum, and examination pitfalls of scrotal US...
  60. ncbi [Ultrasound of the scrotum]
    G Stuckmann
    Institut fur Radiologie, Kantonsspital Winterthur
    Praxis (Bern 1994) 95:709-20. 2006
    ..In cases of acute scrotum or of vascular and inflammatory lesions, Doppler ultrasound is mandatory. This article gives a systematical survey of the most frequent scrotal lesions and their appearance in ultrasound...
  61. ncbi Allopurinol provides long-term protection for experimentally induced testicular torsion in a rabbit model
    Elijah O Kehinde
    Department of Pathology, Facukty of Medicine, Kuwait University, Kuwait
    BJU Int 96:175-80. 2005
    ..To assess the effect of five antioxidants on exocrine function of rabbit testes retained in situ for 24 h and 3 months after experimental torsion...
  62. ncbi Beneficial effect of taurine on testicular ischemia-reperfusion injury in rats
    Si Ming Wei
    Department of Urology, Third Affiliated Hospital of Hangzhou City, Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province, China
    Urology 70:1237-42. 2007
    ..To evaluate the effect of taurine, a potent antioxidant, on testicular ischemia-reperfusion injury due to excess reactive oxygen species produced by neutrophils after testicular torsion-detorsion...
  63. ncbi Salutary effects of N-acetylcysteine on apoptotic damage in a rat model of testicular torsion
    Seyedmehdi Payabvash
    Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Urol Int 79:248-54. 2007
    ..We assessed the effectiveness of systemic administration of NAC, at a therapeutic dose, in a rat model of a 1-hour 720-degree testicular torsion/detorsion...
  64. ncbi [Testicular perfusion injury. Cytokines and cell adhesion molecules in humans]
    H Sperling
    Urologische Klinik, Universitatsklinikum, Essen
    Urologe A 46:1033-40. 2007
    ....
  65. ncbi Cystic appendix epididymis: a sonomorphologic study
    Fatih Kantarci
    Department of Radiology, Cerrahpasa Medical Faculty, Istanbul University, 34300 Istanbul, Turkey
    Surg Radiol Anat 27:557-61. 2005
    ..4%). In conclusion, cystic appearance of the appendix epididymis on sonographic examinations is frequent and it should not be mistaken with a torsed testicular appendage...
  66. ncbi Rosiglitazone, an agonist of peroxisome proliferator-activated receptor-gamma, prevents contralateral testicular ischaemia-reperfusion injury in prepubertal rats
    Mustafa Inan
    Department of Pediatric Surgery, Trakya University Faculty of Medicine, Edirne, Turkey
    Clin Exp Pharmacol Physiol 34:457-61. 2007
    ..In group VI, intense eNOS immunoreactivity was seen in the contralateral testes. 4. Rosiglitazone reduces contralateral testicular damage formed after unilateral testicular torsion and alleviates the oxidative events...
  67. ncbi The protective effects of trimetazidine on testicular ischemia and reperfusion injury in rats
    Cetin Pekcetin
    Department of Histology and Embryology, Dokuz Eylul University Medical School, Balcova, Izmi 35340, Turkey
    Pediatr Surg Int 23:1113-8. 2007
    ..The present results show that TMZ has a protective activity in the testicular injury caused by I/R, and provide the first evidence of the role of TMZ for the prevention of I/R-induced testicular injury...
  68. ncbi Dehydroepiandrosterone treatment attenuates reperfusion injury after testicular torsion and detorsion in rats
    Hulya Aksoy
    Department of Biochemistry, School of Medicine, Ataturk University, TR 25240 Erzurum, Turkey
    J Pediatr Surg 42:1740-4. 2007
    ..We aimed to evaluate the effects of dehydroepiandrosterone (DHEA) on antioxidant enzyme activities, lipid peroxidation, and histopathologic changes in both testes after unilateral testicular torsion and detorsion...
  69. ncbi Protective role of natural antioxidant supplementation on testicular tissue after testicular torsion and detorsion
    Ali Unsal
    Department of Urology, Fatih University, Ankara, Turkey
    Scand J Urol Nephrol 40:17-22. 2006
    ....
  70. ncbi Methylene blue increases contralateral testicular ischaemia-reperfusion injury after unilateral testicular torsion
    Mustafa Inan
    Department of Pediatric Surgery, Trakya University Faculty of Medicine, Edirne, Turkey
    Clin Exp Pharmacol Physiol 35:50-4. 2008
    ..Contrary to our hypothesis, methylene blue increased contralateral testicular damage after unilateral testicular torsion and exacerbated oxidative events...
  71. ncbi Effects of gabexate mesilate on ischemia-reperfusion-induced testicular injury in rats
    Ayten Gezici
    Department of Nuclear Medicine, Dicle University, Medical School, Diyarbakir, Turkey
    Pediatr Surg Int 22:435-41. 2006
    ..However, the injuries in the I-R/untreated rats varied between grade-III and grade-IV. The results of this study show that GM may play a role in reducing the injury caused by I-R...
  72. ncbi Protective effect of L-carnitine on testicular ischaemia-reperfusion injury in rats
    Dikmen Dokmeci
    Department of Pharmacology, Faculty of Medicine, Trakya University, Edirne, Turkey
    Cell Biochem Funct 25:611-8. 2007
    ..In conclusion, L-carnitine pretreatment may have a protective effect in experimental testicular torsion-detorsion model in rats by its well-known antioxidant potential...
  73. ncbi Dexpanthenol attenuates lipid peroxidation and testicular damage at experimental ischemia and reperfusion injury
    Barlas Etensel
    Department of Pediatric Surgery, Adnan Menderes University, Aydin, Turkey
    Pediatr Surg Int 23:177-81. 2007
    ..This effect depends on its antioxidant effect with increasingly reduced glutathione, Coenzyme A and ATP. The effect of Dxp on I/R injury has been shown for the first time in the experimental testicular torsion...
  74. ncbi Increased expression of both constitutive and inducible forms of nitric oxide synthase in the delayed phase of acute experimental testicular torsion
    Changjong Moon
    Department of Veterinary Medicine, Cheju National University, Jeju, South Korea
    J Vet Med Sci 67:453-6. 2005
    ..We postulate that increased expression of the three NOS isoforms in the testis after I/R, which might generate nitric oxide, affects delayed germ cell death following I/R via paracrine or autocrine fashion...
  75. ncbi Propofol reduces nitric oxide-induced apoptosis in testicular ischemia-reperfusion injury by downregulating the expression of inducible nitric oxide synthase
    H Yagmurdur
    Clinic of Anesthesiology and Reanimation, The Ministry of Health Ankara Research and Training Hospital, Ankara, Turkey
    Acta Anaesthesiol Scand 52:350-7. 2008
    ..The aim of the present study was to investigate the underlying mechanisms in the preventive effects of intravenous anesthetics on testicular ischemia-reperfusion injury...
  76. ncbi The effect of zinc aspartate pretreatment on ischemia-reperfusion injury and early changes of blood and tissue antioxidant enzyme activities after unilateral testicular torsion-detorsion
    K U Ozkan
    Department of Pediatric Surgery, Kahramanmaraş Sütçümam University, Medical Faculty, Kahramanmaras, Turkey
    J Pediatr Surg 39:91-5. 2004
    ..The aim of this study is to investigate the effect of zinc aspartate (ZA) pretreatment on ischemia-reperfusion (I/R) injury and blood and tissue antioxidant enzyme activity early after unilateral testicular torsion-detorsion (T/D)...
  77. ncbi Change and significance of the expression of c-kit and SCF following recovery from unilateral testicular torsion in rats
    Yi Guan
    Research Center of Urology and Andrology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China
    Clin Invest Med 31:E98-E105. 2008
    ..To investigate the change in expression levels of c-kit and SCF, and the protective effects of FSH on ischemia-reperfusion injury due to testicular torsion-detorsion...
  78. ncbi The effect of prophylactic melatonin administration on reperfusion damage in experimental testis ischemia-reperfusion
    Ahmet Ozturk
    Selcuk University, School of Medicine, Urology Department, Konya, Turkey
    Neuro Endocrinol Lett 24:170-2. 2003
    ..This study aims at investigating the administration of prophylactic melatonin in order to reduce free radical damage that is caused due to reperfusion after experimental testis torsion-detorsion procedure...
  79. ncbi [Scrotal ultrasonography. Part I: common non-cancerous pathologies]
    C Roy
    Service de Radiologie B, Chir A, Hopitaux Universitaires de Strasbourg, Hopital Civil, 1 Place de l Hopital, BP 426, 67091 Strasbourg
    J Radiol 84:581-95. 2003
    ..When a tumoral process is suspected, surgery is required to confirm the diagnosis and provide histology. The role of MR remains under evaluation...
  80. ncbi The significance of measuring the time course of serum malondialdehyde concentration in patients with torsion of the testis
    Elijah O Kehinde
    Department of Surgery Division of Urology, Mubarak Al Kabeer Teaching Hospital, Faculty of Medicine, Kuwait University, Kuwait
    J Urol 169:2177-80. 2003
    ..We determined the time course of malondialdehyde, a measure of free radical damage, in patients undergoing standard surgical treatment for testicular torsion...
  81. ncbi The effect of poly (adenosine diphosphate-ribose) polymerase inhibitors on biochemical changes in testicular ischemia-reperfusion injury
    Murat Bozlu
    Department of Urology, University of Mersin School of Medicine, Zeytinlibahce Caddesi, 33079 Mersin, Turkey
    J Urol 169:1870-3. 2003
    ..We evaluated the efficacy of poly (ADP-ribose) polymerase inhibitors on biochemical changes in testicular ischemia-reperfusion injury...
  82. ncbi Retrospective review of paediatric patients with acute scrotum
    Imran Mushtaq
    Douglas Cohen Department of General Surgery, Children s Hospital at Westmead, Sydney, New South Wales, Australia
    ANZ J Surg 73:55-8. 2003
    ..The purpose of the present study was to evaluate the historical features and physical examination findings in boys presenting with acute scrotum and to determine the reliability of these modalities to make the correct clinical diagnosis...
  83. ncbi The protective role of caffeic acid phenethyl ester (CAPE) on testicular tissue after testicular torsion and detorsion
    Efkan Uz
    Department of Biochemistry, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey
    World J Urol 20:264-70. 2002
    ..Taken together, our results clearly demonstrate that CAPE treatment exerts a protective effect on testicular T/D, and part of this effect may be due to inhibiting the neutrophil-mediated cellular injury...
  84. ncbi Role of UCH-L1/ubiquitin in acute testicular ischemia-reperfusion injury
    Jinhua Sun
    Department of Genetics and Center for Developmental Biology, College of Life Sciences, Wuhan University, Wuhan 430072, PR China
    Biochem Biophys Res Commun 366:539-44. 2008
    ..These results provide evidences of UCH-L1/ubiquitination signaling to the testis IR injury in vivo...
  85. ncbi Pentoxifylline attenuates reperfusion injury in testicular torsion
    C Savas
    Department of Pediatric Surgery, Suleyman Demirel University Medical School, Isparta, Turkey
    Scand J Urol Nephrol 36:65-70. 2002
    ..An experimental study was designed to evaluate the effects of pentoxifylline (Ptx) on lipid peroxidation, and histopathology in both testes after unilateral testicular torsion and detorsion...
  86. ncbi Protective effect of erythropoietin pretreatment in testicular ischemia-reperfusion injury in rats
    Bekir Ugur Ergur
    Department of Histology and Embryology, Dokuz Eylul University Medical School, Balcova, Izmir 35340, Turkey
    J Pediatr Surg 43:722-8. 2008
    ..This study was designed to investigate the effects of recombinant erythropoietin (EPO), a hormone widely used for treatment of uremic anemia, in rats subjected to testicular ischemia and reperfusion (I/R)...
  87. ncbi Protective effect of vasoactive intestinal peptide on testicular torsion-detorsion injury: association with heparin-containing mast cells
    Cavit Can
    Department ofUrology, Osmangazi University Faculty of Medicine, Eskisehir, Turkey
    Urology 63:195-200. 2004
    ..To elucidate the action of vasoactive intestinal peptide (VIP) on detorsion injury and the heterogeneity of mast cells in the testes of rats...
  88. ncbi Testicular torsion revisited
    John R Mernagh
    Department of Radiology, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Curr Probl Diagn Radiol 33:60-73. 2004
    ..Examples of normal and abnormal anatomy will be presented...
  89. ncbi The protective effect of selenium on ipsilateral and contralateral testes in testicular reperfusion injury
    Dincer Avlan
    Department of Pediatric Surgery, School of Medicine, Mersin University, Zeytinlibahçe 33070, Mersin, Turkey
    Pediatr Surg Int 21:274-8. 2005
    ..These results suggest that ischemia-reperfusion injury occurred in both testes after unilateral testicular T/D and that selenium administration before detorsion prevents reperfusion injury in testicular torsion...
  90. ncbi Effect of Lomodex-MgSO(4) in the prevention of reperfusion injury following unilateral testicular torsion: an experimental study in rats
    Prashant K Adivarekar
    Department of Pediatric Surgery, BJ Wadia Hospital for Children, Mumbai, India
    Pediatr Surg Int 21:184-90. 2005
    ..The presence of agglutinating antibodies could not be detected in the present study...
  91. ncbi Early-onset Escherichia coli sepsis presenting as acute scrotum in preterm infant
    Ming Chou Chiang
    Division of Neonatology, Department of Pediatrics, Chang Gung Children s Hospital, Taoyuan, Taiwan
    Urology 65:389. 2005
    ..coli sepsis. We highlight the importance of sampling proper cultures and using suitable antibiotics after excluding testicular torsion in a neonate with an acute scrotum...
  92. ncbi Significance of determining the point of reperfusion failure in experimental torsion of testis
    Elijah O Kehinde
    Department of Surgery, Faculty of Medicine, Kuwait University, Kuwait
    Int J Urol 12:81-9. 2005
    ..The authors studied I/R injury in the rabbit model, to define the point beyond which there is reperfusion failure...
  93. ncbi The effect of sustained and local administration of epidermal growth factor on improving bilateral testicular tissue after torsion
    S Uguralp
    Department of Pediatric Surgery, Inonu University, Turgut Ozal Medical Center, Malatya, Turkey
    Urol Res 32:323-31. 2004
    ..EGF administration may be a new treatment choice for bilaterally injured testis after detorsion without removing the twisted testis...
  94. ncbi Raxofelast, a hydrophilic vitamin E-like antioxidant, reduces testicular ischemia-reperfusion injury
    Carmelo Romeo
    Department of Medical and Pediatric Surgical Sciences, Neonatal Surgery Unit, University of Messina, Via Consolare Valeria Gazzi, 98124 Messina, Italy
    Urol Res 32:367-71. 2004
    ..These data suggest that the hydrophilic vitamin E-like antioxidants are good candidates for designing a novel therapeutic strategy to halt the oxidative stress that follows acute testis torsion...
  95. ncbi Ultrasound appearances of the testicular appendages: pictorial review
    Maria E K Sellars
    Department of Radiology, King s College Hospital, Denmark Hill, London SE5 9RS, UK
    Eur Radiol 13:127-35. 2003
    ..The varying ultrasound appearances of the testicular appendages are described and illustrated. Ultrasound features of appendiceal torsion are also demonstrated...
  96. ncbi [Torsion of the spermatic cord and testicular annexes]
    P Mongiat-Artus
    Service d Urologie, Universite Paris VII, Hopital Saint Louis, 1, avenue Claude Vellefaux, 75475 Paris Cedex 10, France
    Ann Urol (Paris) 38:25-34. 2004
    ..But the most important improvement should come from parental and teenagers educational information so that they urgently visit a practitioner in case of acute scrotal pain...
  97. ncbi The effect of ATP-MgCl(2) on prevention of reperfusion injury after unilateral testicular torsion
    M Abes
    Department of Pediatric Surgery and Biochemistry, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey
    Eur J Pediatr Surg 11:255-8. 2001
    ..It is concluded that if reperfusion injury has occurred in both testes after unilateral testicular torsion, ATP-MgCl(2) administered before or after detorsion may prevent reperfusion injury in testicular torsion...
  98. ncbi The acute, nontraumatic scrotum: assessment, diagnosis, and management
    Frank L Cole
    Division Head of Emergency Care, School of Nursing, University of Texas Health Science Center, Houston, USA
    J Am Acad Nurse Pract 16:50-6. 2004
    ..Primary and emergency care management are presented...
  99. ncbi Testicular ultrasound
    Michael Blaivas
    Section of Emergency Ultrasound, Department of Emergency Medicine, Medical College of Georgia, 1120 15th Street, AF 2039, Augusta, GA 30912 4007, USA
    Emerg Med Clin North Am 22:723-48, ix. 2004
    ....
  100. ncbi [The acute scrotum]
    R H Ringert
    Klinik für Urologie der Georg August Universität Göttingen
    Z Arztl Fortbild Qualitatssich 92:343-8. 1998
    ..There are many conditions which may present with scrotal swelling including spermatic cord torsion, torsion of testicular appendages, epididymitis, orchitis, incarcerated scrotal hernia, hydrocele, ..
  101. ncbi Ultrasonography is unnecessary in evaluating boys with a nonpalpable testis
    Jack S Elder
    Division of Pediatric Urology, Rainbow Babies and Children s Hospital, Department of Urology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Pediatrics 110:748-51. 2002
    ..An inguinal sonogram often is obtained in boys with a nonpalpable testis to "localize" the testis, ie, determine whether the testis is present. The results of ultrasonography in boys with a nonpalpable testis were analyzed...

Research Grants3

  1. Testicular Torsion: Mechanisms and Treatment
    Terry Turner; Fiscal Year: 2005
    ..It is likely that these investigations will be relevant to other forms of oxidative stress inducing testicular dysfunction. ..
  2. Sertoli Cell Mediated Engulfment of Apoptotic Germ Cells
    Kodi S Ravichandran; Fiscal Year: 2010
    ..abstract_text> ..
  3. Hypoxia and the Role of HIF-1 in the Ischemic Testis
    Michael Palladino; Fiscal Year: 2005
    ..abstract_text> ..