prostatitis

Summary

Summary: Inflammation of the prostate. (Dorland, 27th ed)

Top Publications

  1. ncbi Prostatic MR imaging. Accuracy in differentiating cancer from other prostatic disorders
    S Ikonen
    Department of Radiology, Helsinki University Central Hospital, and The Finnish Institute of Occupational Health, Helsinki, Finland
    Acta Radiol 42:348-54. 2001
  2. pmc CCL2 and CCL3 are essential mediators of pelvic pain in experimental autoimmune prostatitis
    Marsha L Quick
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Am J Physiol Regul Integr Comp Physiol 303:R580-9. 2012
  3. pmc Prostatitis, sexually transmitted diseases, and prostate cancer: the California Men's Health Study
    Iona Cheng
    Epidemiology Program, Cancer Research Center of Hawai i, University of Hawai i, Honolulu, Hawai i, United States of America
    PLoS ONE 5:e8736. 2010
  4. ncbi The controversial relationship between benign prostatic hyperplasia and prostate cancer: the role of inflammation
    Cosimo De Nunzio
    Department of Urology, Sant Andrea Hospital, University La Sapienza, Rome, Italy
    Eur Urol 60:106-17. 2011
  5. ncbi Seminal plasma cytokines and chemokines in prostate inflammation: interleukin 8 as a predictive biomarker in chronic prostatitis/chronic pelvic pain syndrome and benign prostatic hyperplasia
    Giuseppe Penna
    BioXell, Milan, Italy
    Eur Urol 51:524-33; discussion 533. 2007
  6. ncbi Epidemiologic association between prostatitis and prostate cancer
    Leslie K Dennis
    Department of Epidemiology, University of Iowa College of Public Health, Iowa City, Iowa 52242, USA
    Urology 60:78-83. 2002
  7. ncbi Presence of INFgamma-secreting lymphocytes specific to prostate antigens in a group of chronic prostatitis patients
    Ruben Dario Motrich
    Centro de Investigaciones en Bioquímica Clínica e Inmunología CIBICI CONICET Departamento de Bioquímica Clínica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba 5000, Argentina
    Clin Immunol 116:149-57. 2005
  8. ncbi Chronic prostatitis/chronic pelvic pain syndrome
    Michel A Pontari
    Department of Urology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Urol Clin North Am 35:81-9; vi. 2008
  9. ncbi Validation and comparison of EuroQol and short form 6D in chronic prostatitis patients
    Fei Li Zhao
    University of Newcastle, Callaghan, NSW, Australia
    Value Health 13:649-56. 2010
  10. ncbi PSA is a candidate self-antigen in autoimmune chronic prostatitis/chronic pelvic pain syndrome
    S Ponniah
    Division of Urology, University of Maryland School of Medicine, and Section of Urology, VA Maryland Health Care System, Baltimore, Maryland 21201, USA
    Prostate 44:49-54. 2000

Research Grants

  1. VIRULENCE FACTORS OF CHLAMYDIAE
    PRISCILLA WYRICK; Fiscal Year: 2009
  2. Advanced Nitric Oxide Release Bactericidal Urinary Catheters
    Mark E Meyerhoff; Fiscal Year: 2013
  3. Rho-Modifying Cytotoxic Necrotizing Factor of E. coli
    ALISON DAVIS O'BRIEN; Fiscal Year: 2013
  4. FUNCTION OF THE ENTERIC NERVOUS SYSTEM
    JACKIE WOOD; Fiscal Year: 2013
  5. Cholesterol and Prostate Health
    Michael R Freeman; Fiscal Year: 2013
  6. Development of Nonhuman Primate Models for PSA Biology Studies
    JAMES NKAMBWE MUBIRU; Fiscal Year: 2013
  7. Mapping serotonin receptors in lower urinary tract innervation
    E Michelle Southard-Smith; Fiscal Year: 2013
  8. Multi-Disciplinary Evaluation of Chronic Pelvic Pain Syndrome
    GERALD LOUIS ANDRIOLE; Fiscal Year: 2012
  9. Energy Balance-Related Hormones &Prostate Cancer Incidence &Progression
    Edward Giovannucci; Fiscal Year: 2012
  10. A Novel Surface Sensing Pathway in Proteus mirabilis
    Philip N Rather; Fiscal Year: 2013

Detail Information

Publications249 found, 100 shown here

  1. ncbi Prostatic MR imaging. Accuracy in differentiating cancer from other prostatic disorders
    S Ikonen
    Department of Radiology, Helsinki University Central Hospital, and The Finnish Institute of Occupational Health, Helsinki, Finland
    Acta Radiol 42:348-54. 2001
    ..Twenty patients had prostatic cancer, 20 benign prostatic hyperplasia (BPH), 4 acute bacterial prostatitis, 5 chronic bacterial prostatitis (2 also belonging to the previous category), 19 chronic non-bacterial ..
  2. pmc CCL2 and CCL3 are essential mediators of pelvic pain in experimental autoimmune prostatitis
    Marsha L Quick
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Am J Physiol Regul Integr Comp Physiol 303:R580-9. 2012
    Experimental autoimmune prostatitis (EAP) is a murine model of chronic prostatitis/chronic pelvic pain syndrome (CPPS) in men, a syndrome characterized by chronic pelvic pain...
  3. pmc Prostatitis, sexually transmitted diseases, and prostate cancer: the California Men's Health Study
    Iona Cheng
    Epidemiology Program, Cancer Research Center of Hawai i, University of Hawai i, Honolulu, Hawai i, United States of America
    PLoS ONE 5:e8736. 2010
    b>Prostatitis and sexually transmitted diseases (STDs) have been positively associated with prostate cancer in previous case-control studies. However, results from recent prospective studies have been inconclusive...
  4. ncbi The controversial relationship between benign prostatic hyperplasia and prostate cancer: the role of inflammation
    Cosimo De Nunzio
    Department of Urology, Sant Andrea Hospital, University La Sapienza, Rome, Italy
    Eur Urol 60:106-17. 2011
    ..Recent data suggest that prostatic inflammation is involved in the pathogenesis and progression of both conditions...
  5. ncbi Seminal plasma cytokines and chemokines in prostate inflammation: interleukin 8 as a predictive biomarker in chronic prostatitis/chronic pelvic pain syndrome and benign prostatic hyperplasia
    Giuseppe Penna
    BioXell, Milan, Italy
    Eur Urol 51:524-33; discussion 533. 2007
    This prospective study quantified cytokine and chemokine levels in seminal plasma of patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and benign prostatic hyperplasia (BPH), to evaluate inflammatory mediators as ..
  6. ncbi Epidemiologic association between prostatitis and prostate cancer
    Leslie K Dennis
    Department of Epidemiology, University of Iowa College of Public Health, Iowa City, Iowa 52242, USA
    Urology 60:78-83. 2002
    To quantify the relationship between prostatitis and prostate cancer by pooling previous epidemiologic studies of this association.
  7. ncbi Presence of INFgamma-secreting lymphocytes specific to prostate antigens in a group of chronic prostatitis patients
    Ruben Dario Motrich
    Centro de Investigaciones en Bioquímica Clínica e Inmunología CIBICI CONICET Departamento de Bioquímica Clínica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba 5000, Argentina
    Clin Immunol 116:149-57. 2005
    Acute and chronic infectious prostatitis are the best understood of the prostate syndromes, but they are the least frequent...
  8. ncbi Chronic prostatitis/chronic pelvic pain syndrome
    Michel A Pontari
    Department of Urology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Urol Clin North Am 35:81-9; vi. 2008
    In the 20th century, the term "prostatitis" traditionally referred to inflammation in the prostate, often attributed to infection...
  9. ncbi Validation and comparison of EuroQol and short form 6D in chronic prostatitis patients
    Fei Li Zhao
    University of Newcastle, Callaghan, NSW, Australia
    Value Health 13:649-56. 2010
    ..However, to our knowledge, no such HRQoL instrument has been validated or used in chronic prostatitis. We therefore aimed to assess and compare the psychometric properties of EuroQol (EQ-5D) and Short Form 6D (SF-..
  10. ncbi PSA is a candidate self-antigen in autoimmune chronic prostatitis/chronic pelvic pain syndrome
    S Ponniah
    Division of Urology, University of Maryland School of Medicine, and Section of Urology, VA Maryland Health Care System, Baltimore, Maryland 21201, USA
    Prostate 44:49-54. 2000
    Previous studies demonstrated that recognition of seminal plasma antigens can occur in patients with chronic prostatitis/chronic pelvic pain syndrome. This suggests that an autoimmune component may contribute to symptoms in some men...
  11. pmc Evaluation of prostatitis in autopsied prostates--is chronic inflammation more associated with benign prostatic hyperplasia or cancer?
    Nicolas B Delongchamps
    Department of Urology, State University of New York Upstate Medical University, New York 13210, USA
    J Urol 179:1736-40. 2008
    ..However, the prevalence of chronic inflammation in malignant and benign glands has not been compared. We evaluated the association of inflammation, benign prostatic hyperplasia and cancer in autopsied prostates...
  12. ncbi Clinical phenotyping of patients with chronic prostatitis/chronic pelvic pain syndrome and correlation with symptom severity
    Daniel A Shoskes
    Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Urology 73:538-42; discussion 542-3. 2009
    ..We wished to validate this system in men with chronic pelvic pain syndrome (CPPS). CPPS is a heterogeneous syndrome with a variable treatment response...
  13. ncbi Prostatitis
    Michel A Pontari
    Department of Urology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    J Urol 177:2050-7. 2007
    We quantified the burden of prostatitis in the United States by identifying trends in the use of health care resources and estimating the economic impact of the disease.
  14. ncbi Willingness to pay per quality-adjusted life year: is one threshold enough for decision-making?: results from a study in patients with chronic prostatitis
    Fei Li Zhao
    School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia
    Med Care 49:267-72. 2011
    To estimate the willingness to pay (WTP) per quality-adjusted life year (QALY) ratio with the stated preference data and compare the results obtained between chronic prostatitis (CP) patients and general population (GP).
  15. pmc Inflammation in prostate carcinogenesis
    Angelo M De Marzo
    Johns Hopkins University School of Medicine, Department of Pathology, Baltimore, MD, USA
    Nat Rev Cancer 7:256-69. 2007
    ....
  16. pmc Vinclozolin exposure in utero induces postpubertal prostatitis and reduces sperm production via a reversible hormone-regulated mechanism
    Prue A Cowin
    Monash Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia
    Endocrinology 151:783-92. 2010
    ..We previously reported in utero Vinclozolin exposure-induced prostatitis (prostate inflammation) in postpubertal rats concurrent with down-regulation of AR and increased nuclear factor-..
  17. ncbi Chronic pelvic pain syndrome/chronic prostatitis affect the acrosome reaction in human spermatozoa
    Ralf Henkel
    Department of Medical Biosciences, University of the Western Cape, Private Bag X17, 7535 Bellville, South Africa
    World J Urol 24:39-44. 2006
    ..004) and spontaneous AR increased (P < 0.02). Our data clearly demonstrate a significant influence of the inflammation on acrosomal functionality, which could be mediated by inflammatory mediators like ROS...
  18. ncbi Significance of inflammation on standard semen analysis in chronic prostatitis/chronic pelvic pain syndrome
    M Ludwig
    Klinik und Poliklinik für Urologie und Kinderurologie Institut für Medizinische Informatik, Universitätsklinikum Giessen, Germany
    Andrologia 35:152-6. 2003
    ..Basic spermiogram parameters has been analysed in patients with inflammatory and noninflammatory chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS-NIH IIIA/IIIB) with regard to indicators of inflammation in prostatic ..
  19. ncbi Prostate biopsy culture findings of men with chronic pelvic pain syndrome do not differ from those of healthy controls
    Jay C Lee
    Department of Urology, University of Washington, Seattle, Washington, USA
    J Urol 169:584-7; discussion 587-8. 2003
    ..To examine whether prostatic bacteria are more prevalent among patients with chronic pelvic pain syndrome than among those without pelvic pain, we compared 4-glass urine test and prostate biopsy results...
  20. ncbi Prostatitis: diagnosis and treatment
    Victoria J Sharp
    University of Iowa Health Care, Iowa City, 52242 1089, USA
    Am Fam Physician 82:397-406. 2010
    b>Prostatitis ranges from a straightforward clinical entity in its acute form to a complex, debilitating condition when chronic. It is often a source of frustration for the treating physician and patient...
  21. ncbi Examination of the relationship between symptoms of prostatitis and histological inflammation: baseline data from the REDUCE chemoprevention trial
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Kingston, Ontario, Canada
    J Urol 178:896-900; discussion 900-1. 2007
    Symptoms of abacterial chronic prostatitis/chronic pelvic pain syndrome are considered to be associated with prostate inflammation...
  22. ncbi Health-related quality of life in Chinese patients with chronic prostatitis/chronic pelvic pain syndrome
    Fei Li Zhao
    Discipline of Pharmacy and Experimental Pharmacology, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia
    Qual Life Res 19:1273-83. 2010
    ..the health-related quality of life (HRQoL) and factors associated with HRQoL in Chinese patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) using two generic preference-based HRQoL instruments, EQ-5D (plus EQ-VAS)..
  23. ncbi Epidemiologic risk factors for chronic prostatitis
    Ja Hyeon Ku
    Department of Urology, Seoul Veterans Hospital, Seoul, Korea
    Int J Androl 28:317-27. 2005
    Chronic prostatitis/chronic pelvic pain syndrome is a multifactorial problem, which affects men of all ages and in all demographics...
  24. ncbi The role of the urinary epithelium in the pathogenesis of interstitial cystitis/prostatitis/urethritis
    C Lowell Parsons
    Division of Urology, Department of Surgery, University of California, San Diego Medical Center, University of California, San Diego, San Diego, California 92103 8897, USA
    Urology 69:9-16. 2007
    ..Groups of patients who have been given a diagnosis of IC, chronic prostatitis, and urethritis have been shown to have IC by virtue of their shared potassium sensitivity...
  25. ncbi Leukocytes and bacteria in men with chronic prostatitis/chronic pelvic pain syndrome compared to asymptomatic controls
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, 76 Stuart Street, Kingston, Ontario K7L 2V7, Canada
    J Urol 170:818-22. 2003
    Chronic prostatitis has been traditionally characterized by inflammation and/or infection of the prostate gland, objectively categorized by white blood cells and cultured bacteria in prostate specific specimens...
  26. ncbi Chronic prostatitis and male accessory gland infection--is there an impact on male infertility (diagnosis and therapy)?
    K Everaert
    Department of Urology, Ghent University Hospital, Ghent, Belgium
    Andrologia 35:325-30. 2003
    ..male infertility, extrapolate this hypothesis to male accessory gland infection (MAGI) and relate it to chronic prostatitis and its treatment. Infertility is a multifactorial disease and diagnosis and therapy must be oriented as such...
  27. ncbi A case-control study of risk factors in men with chronic pelvic pain syndrome
    Michel A Pontari
    Temple University School of Medicine, Philadelphia, PA 19140, USA
    BJU Int 96:559-65. 2005
    To compare the demographic, behavioural, clinical and medical history characteristics of men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and asymptomatic controls, to identify characteristics that might be associated ..
  28. ncbi Differentiation of prostatitis and prostate cancer by using diffusion-weighted MR imaging and MR-guided biopsy at 3 T
    Klaas N A Nagel
    Department of Technical Medicine, University of Twente, Enschede, The Netherlands
    Radiology 267:164-72. 2013
    To determine if prostatitis and prostate cancer (PCa) can be distinguished by using apparent diffusion coefficients (ADCs) on magnetic resonance (MR) images, with specimens obtained at MR-guided biopsy as the standard of reference.
  29. pmc The prevalence and overlap of interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome in men: results of the RAND Interstitial Cystitis Epidemiology male study
    Anne M Suskind
    Department of Urology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Urol 189:141-5. 2013
    ..validated case definitions to identify interstitial cystitis/bladder pain syndrome in women and chronic prostatitis/chronic pelvic pain syndrome in men...
  30. ncbi Non-obese diabetic (NOD) mice are genetically susceptible to experimental autoimmune prostatitis (EAP)
    V E Rivero
    Faculty of Chemical Sciences, National University of Cordoba
    J Autoimmun 11:603-10. 1998
    Rodents develop inflammatory, non-infectious, prostatitis upon autoimmuniz-ation with male accessory gland (MAG) extracts in complete Freund's adjuvant (CFA)...
  31. pmc PCR for diagnosis of male Trichomonas vaginalis infection with chronic prostatitis and urethritis
    Jong Jin Lee
    Prime Urology Clinic, Gwangmyeong 423 807, Korea
    Korean J Parasitol 50:157-9. 2012
    ..usefulness of PCR for diagnosis of Trichomonas vaginalis infection among male patients with chronic recurrent prostatitis and urethritis...
  32. ncbi Chronic prostatitis and small intestinal bacterial overgrowth: effect of rifaximin
    Leonard B Weinstock
    Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Can J Urol 18:5826-30. 2011
    This pilot study determined the efficacy of rifaximin, a gut-directed antibiotic, in reducing chronic prostatitis (CP) and gastrointestinal (GI) symptoms in patients with CP type III...
  33. ncbi Reduced semen quality in chronic prostatitis patients that have cellular autoimmune response to prostate antigens
    Ruben Dario Motrich
    Inmunologia, CIBICI CONICET, Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Argentina
    Hum Reprod 20:2567-72. 2005
    The relationship between chronic prostatitis and fertility has been controversial for many years...
  34. pmc Psychometric profiles and hypothalamic-pituitary-adrenal axis function in men with chronic prostatitis/chronic pelvic pain syndrome
    Rodney U Anderson
    Department of Urology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Urol 179:956-60. 2008
    ..Chronic stress may have a role in the disorder of chronic prostatitis/chronic pelvic pain syndrome related to initiation or exacerbation of the syndrome...
  35. ncbi Prevalence of prostatitis-like symptoms in a population based study using the National Institutes of Health chronic prostatitis symptom index
    J C Nickel
    Department of Urology, Queen's University, Kingston, Ontario, Canada
    J Urol 165:842-5. 2001
    PURPOSE: The National Institutes of Health (NIH) chronic prostatitis symptom index was used to determine the prevalence of prostatitis-like symptoms among men (age 20 to 74 years) at risk in a community based study...
  36. ncbi Brain functional and anatomical changes in chronic prostatitis/chronic pelvic pain syndrome
    Melissa A Farmer
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    J Urol 186:117-24. 2011
    Research into the pathophysiology of chronic prostatitis/chronic pelvic pain syndrome has primarily focused on markers of peripheral dysfunction...
  37. ncbi Sexual behavior, sexually transmitted diseases and prostatitis: the risk of prostate cancer in black men
    Aruna V Sarma
    Department of Urology, University of Michigan Health System, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0330, USA
    J Urol 176:1108-13. 2006
    ..In concurrence, population based studies of white men have revealed an increased risk of prostate cancer with history of sexually transmitted diseases and prostatitis.
  38. ncbi Treatment of chronic prostatitis lowers serum prostate specific antigen
    Caleb B Bozeman
    Department of Urology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA
    J Urol 167:1723-6. 2002
    We evaluated men with documented chronic prostatitis and elevated serum prostate specific antigen (PSA) to determine whether treatment with antibiotics and anti-inflammatory drugs lowers serum PSA.
  39. ncbi Chronic bacterial infection and inflammation incite reactive hyperplasia in a mouse model of chronic prostatitis
    Johny E Elkahwaji
    Department of Surgery, Division of Urology, University of Wisconsin School of Medicine and Public Health, 600, Highland Ave, Madison, WI 53792, USA
    Prostate 67:14-21. 2007
    Chronic inflammation is postulated to contribute to prostate carcinogenesis. We developed a mouse model of chronic prostatitis to test whether infection-induced chronic inflammation would incite reactive changes in prostatic epithelium.
  40. ncbi Prevalence of and risk factors for prostatitis: population based assessment using physician assigned diagnoses
    J Quentin Clemens
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Urol 178:1333-7. 2007
    Previous studies to assess risk factors for prostatitis used patient self-reported data and, therefore, they were subject to recall bias...
  41. ncbi Fears, sexual disturbances and personality features in men with prostatitis: a population-based cross-sectional study in Finland
    A Mehik
    Division of Urology, Department of Surgery, Oulu University Hospital, Finland
    BJU Int 88:35-8. 2001
    To determine the occurrence of mental distress related to prostatitis in Finnish men.
  42. ncbi The prevalence of prostatitis-like symptoms in China
    Chao Zhao Liang
    Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
    J Urol 182:558-63. 2009
    We studied the prevalence of prostatitis-like symptoms and identified their associated risk factors in a population based Chinese sample.
  43. ncbi A pollen extract (Cernilton) in patients with inflammatory chronic prostatitis-chronic pelvic pain syndrome: a multicentre, randomised, prospective, double-blind, placebo-controlled phase 3 study
    Florian M E Wagenlehner
    Clinic for Urology, Paediatric Urology and Andrology, Justus Liebig University of Giessen, Giessen, Germany
    Eur Urol 56:544-51. 2009
    National Institutes of Health (NIH) category III prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent condition for which no standardised treatment exists.
  44. ncbi A prospective study of symptoms and quality of life in men with chronic prostatitis/chronic pelvic pain syndrome: the National Institutes of Health Chronic Prostatitis Cohort study
    Kathleen Joy Propert
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    J Urol 175:619-23; discussion 623. 2006
    ..We present the results of 2 years of symptom and quality of life followup of men with CP/CPPS enrolled in the CPC...
  45. ncbi Prevalence of asymptomatic inflammatory (National Institutes of Health Category IV) prostatitis in young men according to semen analysis
    Paul Korrovits
    Andrology Center, Tartu University Hospital, Tartu, Estonia
    Urology 71:1010-5. 2008
    To determine the prevalence of asymptomatic inflammatory (National Institutes of Health category IV) prostatitis in a cross-sectional community sample of young men.
  46. ncbi IgG4-related autoimmune prostatitis: two cases with or without autoimmune pancreatitis
    Isao Nishimori
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku
    Intern Med 46:1983-9. 2007
    ..We report herein two cases with prostatitis. One was seen in a patient with typical AIP, and the other was observed without any clinical manifestation of ..
  47. ncbi Pain sensitization in male chronic pelvic pain syndrome: why are symptoms so difficult to treat?
    Claire C Yang
    Department of Urology, Box 356510, University of Washington, 1959 N E Pacific Street, Seattle, WA 98195 6510, USA
    J Urol 170:823-6; discussion 826-7. 2003
    ..We evaluated men with and without CPPS to determine if there were differences between the 2 groups in their responses to noxious heat stimuli...
  48. ncbi Extracorporeal shock wave therapy for the treatment of chronic pelvic pain syndrome in males: a randomised, double-blind, placebo-controlled study
    Reinhold Zimmermann
    Department of Urology, Elisabethinen Hospital, University Affiliated Hospital, Linz, Austria
    Eur Urol 56:418-24. 2009
    ..There is no sufficiently validated therapy for chronic pelvic pain syndrome (CPPS)...
  49. ncbi Epidemiology of inflammation and prostate cancer
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, The Brady Urological Institute, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland 21205, USA
    J Urol 171:S36-40. 2004
    ....
  50. pmc Mechanisms in prostatitis/chronic pelvic pain syndrome
    Michel A Pontari
    Department of Urology, Temple University School of Medicine, 3401 N Broad Street, Philadelphia, PA 19140, USA
    J Urol 172:839-45. 2004
    We reviewed the current literature on mechanisms involved in the pathogenesis of prostatitis/chronic pelvic pain syndrome (CPPS).
  51. ncbi Immunological alterations in the ejaculate of chronic prostatitis patients: clues for autoimmunity
    H John
    Clinic of Urology, University Hospital and University of Zurich, Zurich, Switzerland
    Andrologia 35:294-9. 2003
    ..Thirty-five patients of a total of 88 patients with chronic prostatitis Cat IIIB were consecutively selected...
  52. ncbi Current challenges in the treatment of complicated urinary tract infections and prostatitis
    F M E Wagenlehner
    Department of Urology, Hospital St Elisabeth, Straubing, Germany
    Clin Microbiol Infect 12:67-80. 2006
    Serious urinary tract infections (UTIs) and acute bacterial prostatitis in adults cause significant morbidity and economic burden...
  53. ncbi Intraprostatic capsaicin injection as a novel model for nonbacterial prostatitis and effects of botulinum toxin A
    Yao Chi Chuang
    Department of Urology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Eur Urol 51:1119-27. 2007
    An animal model for nonbacterial prostatitis in rats was developed with the use of intraprostatic injection of capsaicin, an agent thought to excite C-afferent fibers and cause neurogenic inflammation...
  54. ncbi How does the pre-massage and post-massage 2-glass test compare to the Meares-Stamey 4-glass test in men with chronic prostatitis/chronic pelvic pain syndrome?
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Kingston, Ontario, Canada
    J Urol 176:119-24. 2006
    ..inflammation and the presence of bacteria in the lower urinary tract in men presenting with the chronic prostatitis syndrome...
  55. ncbi Bacteria in the chronic prostatitis-chronic pelvic pain syndrome: molecular approaches to critical research questions
    John N Krieger
    Department of Urology, University of Washington School of Medicine, Seattle, WA, USA
    J Urol 167:2574-83. 2002
    There is a pressing need to determine the causes and consequences of, and optimal therapy for the chronic prostatitis-chronic pelvic pain syndrome.
  56. ncbi Clinical phenotyping in chronic prostatitis/chronic pelvic pain syndrome and interstitial cystitis: a management strategy for urologic chronic pelvic pain syndromes
    D A Shoskes
    Glickman Urological and Kidney Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
    Prostate Cancer Prostatic Dis 12:177-83. 2009
    The urologic chronic pain conditions such as chronic prostatitis/chronic pelvic pain syndrome and interstitial cystitis are syndromes whose evaluation and management are controversial...
  57. ncbi A prospective, randomized, double-blind trial to evaluate the role of a short reducing course of oral corticosteroid therapy in the treatment of chronic prostatitis/chronic pelvic pain syndrome
    Sylvia M Bates
    Department of Genito Urinary Medicine, Royal Hallamshire Hospital, Sheffield, UK
    BJU Int 99:355-9. 2007
    ..To assess the validity of our observational experience that a short course of oral prednisolone therapy might be of value in the management of symptoms of chronic pelvic pain syndrome (CPPS) in men...
  58. ncbi Effect of NIH-IV prostatitis on free and free-to-total PSA
    Igor Stancik
    Urology Department, Kaiser Franz Josef Hospital, Kundratstrasse 3, 1100 Vienna, Austria
    Eur Urol 46:760-4. 2004
    To examine the effect of asymptomatic prostatic inflammation (NIH category IV prostatitis) on total PSA (tPSA), free serum PSA (fPSA) and the ratio of free-to-total prostate specific antigen (%fPSA)...
  59. ncbi Phenotypically directed multimodal therapy for chronic prostatitis/chronic pelvic pain syndrome: a prospective study using UPOINT
    Daniel A Shoskes
    Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Urology 75:1249-53. 2010
    ..In this study, we treated patients with multimodal therapy based on the UPOINT phenotype and measured response after at least 6 months...
  60. pmc Pseudomonas aeruginosa acute prostatitis and urosepsis after sexual relations in a hot tub
    Lori M Dulabon
    Department of Urology, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA
    J Clin Microbiol 47:1607-8. 2009
    We report a case of a previously healthy 38-year-old male with acute prostatitis and concurrent Pseudomonas aeruginosa urosepsis...
  61. ncbi Eradication of Enterococcus faecalis by phage therapy in chronic bacterial prostatitis--case report
    S Letkiewicz
    Urological and Andrological Clinic UROGEN, 42 600, Tarnowskie Góry, Poland
    Folia Microbiol (Praha) 54:457-61. 2009
    The treatment of three patients suffering from chronic bacterial prostatitis who were qualified for an experimental phage therapy protocol managed at the Phage Therapy Unit in Wrocław is described...
  62. ncbi Chlamydia trachomatis occurrence and its impact on sperm quality in chronic prostatitis patients
    Ruben Dario Motrich
    Centro de Investigaciones en Bioquímica Clínica e Inmunología CIBICI CONICET, Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, Cordoba, Argentina
    J Infect 53:175-83. 2006
    The role of Chlamydia trachomatis (CT) in the pathogenesis of chronic prostatitis and its impact on male fertility remain controversial...
  63. ncbi Demographic and clinical characteristics of men with chronic prostatitis: the national institutes of health chronic prostatitis cohort study
    Anthony J Schaeffer
    Department of Urology, Northwestern University, Chicago, Illinois 60611, USA
    J Urol 168:593-8. 2002
    We describe the study design of the National Institutes of Health Chronic Prostatitis Cohort (CPC) study characterizing men with chronic prostatitis/the chronic pelvic pain syndrome.
  64. ncbi Chlamydia trachomatis infection is related to poor semen quality in young prostatitis patients
    Sandra Mazzoli
    Sexually Transmitted Disease Centre, Santa Maria Annunziata Hospital, Florence, Italy
    Eur Urol 57:708-14. 2010
    The impact of chronic prostatitis resulting from Chlamydia trachomatis infection on male fertility is controversial.
  65. ncbi Adverse impact of sexual dysfunction in chronic prostatitis/chronic pelvic pain syndrome
    Shaun Wen Huey Lee
    School of Pharmaceutical Sciences, University of Science Malaysia, Penang, Malaysia
    Urology 71:79-84. 2008
    ..To examine the prevalence, characteristics, and impact of sexual dysfunction in our primary care referral population...
  66. ncbi Autoimmune prostatitis: state of the art
    R D Motrich
    Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Haya de la Torre y Medina Allende, Ciudad Universitaria, Cordoba, Argentina
    Scand J Immunol 66:217-27. 2007
    ..Pathological conditions of the prostate gland range from infections, chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) of a still unknown aetiology to benign hyperplasia and cancer...
  67. ncbi The association between varicocele, premature ejaculation and prostatitis symptoms: possible mechanisms
    Francesco Lotti
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence 50139, Italy
    J Sex Med 6:2878-87. 2009
    ..No study has ever systematically evaluated the impact of varicocele on sexual function...
  68. ncbi Prostatitis/chronic pelvic pain syndrome
    Geoffrey M Habermacher
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Annu Rev Med 57:195-206. 2006
    We review the diagnosis, categorization, and treatment of prostatitis/chronic pelvic pain syndrome based on the National Institutes of Health (NIH) classification. Prostatitis is an extremely common syndrome that afflicts 2%-10% of men...
  69. ncbi Prostatitis as a risk factor for prostate cancer
    Rosebud O Roberts
    Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Epidemiology 15:93-9. 2004
    ..The association of infection or inflammation of the prostate with prostate cancer has been suggested but not established. This study was undertaken to investigate this association...
  70. ncbi The correlation between serum prostate specific antigen levels and asymptomatic inflammatory prostatitis
    Cuneyt Ozden
    Department of Urology, Numune Education and Research Hospital, Cevizlidere Mah 14 Cad, Balgat 12 25, Ankara, 06100, Turkey
    Int Urol Nephrol 39:859-63. 2007
    Asymptomatic inflammatory prostatitis is a common pathological finding in patients with benign prostatic hyperplasia (BPH)...
  71. ncbi Nanobacteria: a possible etiology for type III prostatitis
    Xuecheng Shen
    Urological Research Institute of PLA, Southwest Hospital, Third Military Medical University, Chongqing, People s Republic of China
    J Urol 184:364-9. 2010
    ..We observed pathological changes in nanobacteria infected prostates in Sprague-Dawley(R) rats and investigated the possible etiological relationships of nanobacteria and type III prostatitis.
  72. ncbi Interleukin-8 levels in seminal plasma in chronic prostatitis/chronic pelvic pain syndrome and nonspecific urethritis
    Abbas Khadra
    Department of Clinical Development Sciences Genitourinary Medicine, St George s, University of London, London
    BJU Int 97:1043-6. 2006
    To investigate whether a range of cytokines were detectable in the seminal plasma and urine of men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and nonspecific urethritis (NSU), and whether cytokine levels correlated ..
  73. ncbi Nerve growth factor and chronic prostatitis/chronic pelvic pain syndrome
    Lauri J Miller
    Department of Pathology, University of Connecticut School of Medicine and School of Dental Medicine, Farmington, Connecticut 06030, USA
    Urology 59:603-8. 2002
    To investigate whether the pain experienced by patients with chronic prostatitis/chronic pelvic pain syndrome (CPPS) may be related to the expression of nerve growth factor (NGF), induced by inflammation and tissue injury experienced as ..
  74. ncbi Alfuzosin treatment for chronic prostatitis/chronic pelvic pain syndrome: a prospective, randomized, double-blind, placebo-controlled, pilot study
    Aare Mehik
    Division of Urology, Department of Surgery, Oulu University, Oulu, Finland
    Urology 62:425-9. 2003
    ..examine the long-term efficacy of alfuzosin compared with placebo and standard therapy in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), because alpha-blockers have been suggested for the treatment of CP/CPPS.
  75. ncbi Prevalence of sexual dysfunction in Chinese men with chronic prostatitis
    Chao Zhao Liang
    Department of Urology, First Affiliated Hospital of Anhui Medical University, Anhui, China
    BJU Int 93:568-70. 2004
    To investigate the prevalence and risk factors of sexual dysfunction in Chinese men with chronic prostatitis.
  76. ncbi Long-term results of multimodal therapy for chronic prostatitis/chronic pelvic pain syndrome
    Daniel A Shoskes
    Cleveland Clinic Florida, Weston and Nova Southeastern University, Ft Lauderdale, USA
    J Urol 169:1406-10. 2003
    Chronic prostatitis/chronic pelvic pain syndrome is a prevalent and multifactorial condition. Many patients have the condition for years despite conventional therapies...
  77. ncbi Treatment of chronic prostatitis/chronic pelvic pain syndrome with tamsulosin: a randomized double blind trial
    J Curtis Nickel
    Queen s University, Kingston, Ontario, Canada
    J Urol 171:1594-7. 2004
    We compared the efficacy of tamsulosin with placebo for the treatment of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).
  78. pmc Loss of Nkx3.1 expression in bacterial prostatitis: a potential link between inflammation and neoplasia
    May Khalili
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250, USA
    Am J Pathol 176:2259-68. 2010
    ..To determine the effect of inflammation on Nxk3.1 accumulation, bacterial prostatitis was induced by intraurethral inoculation of a uropathogenic E. coli strain in mice. Nkx3...
  79. ncbi The prevalence of men with National Institutes of Health category IV prostatitis and association with serum prostate specific antigen
    Brett S Carver
    Department of Urology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA
    J Urol 169:589-91. 2003
    We evaluated the prevalence and relationship of serum prostate specific antigen (PSA) levels in a screening population of men diagnosed with National Institutes of Health (NIH) category IV prostatitis.
  80. ncbi Acupuncture versus sham acupuncture for chronic prostatitis/chronic pelvic pain
    Shaun Wen Huey Lee
    School of Pharmaceutical Science, University of Science, Malaysia
    Am J Med 121:79.e1-7. 2008
    Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) afflicts 2%-10% of adult men. Available therapies offer little or no proven benefit...
  81. ncbi Pentosan polysulfate sodium therapy for men with chronic pelvic pain syndrome: a multicenter, randomized, placebo controlled study
    J Curtis Nickel
    Department of Urology, Queens University, Kingston, Ontario, Canada
    J Urol 173:1252-5. 2005
    ..We evaluated the efficacy and tolerability of pentosan polysulfate sodium (PPS) for the treatment of men with chronic pelvic pain syndrome (CPPS), National Institutes of Health (NIH) category III...
  82. ncbi Terazosin therapy for chronic prostatitis/chronic pelvic pain syndrome: a randomized, placebo controlled trial
    Phaik Yeong Cheah
    School of Pharmaceutical Sciences, University of Science Malaysia, Penang, Malaysia
    J Urol 169:592-6. 2003
    We evaluate terazosin therapy for chronic prostatitis/chronic pelvic pain syndrome.
  83. ncbi Acute bacterial prostatitis after transrectal prostate needle biopsy: clinical analysis
    Kazuyoshi Shigehara
    Department of Urology, Ishikawa Prefectural Central Hospital, 2 1 Kuratsukihigashi, Kanazawa, Ishikawa, Japan
    J Infect Chemother 14:40-3. 2008
    We investigated the incidence and characteristics of acute bacterial prostatitis after transrectal prostate biopsy, based on urine and blood cultures, treatment method, and outcome...
  84. ncbi Gonorrhea, syphilis, clinical prostatitis, and the risk of prostate cancer
    Siobhan Sutcliffe
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Room E6138, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 15:2160-6. 2006
    Although previous case-control studies have observed positive associations among gonorrhea, syphilis, clinical prostatitis, and prostate cancer, many may have been susceptible to recall and interviewer biases due to their retrospective ..
  85. ncbi Conventional bacteriology in prostatitis patients: microbiological bias, problems and epidemiology on 1686 microbial isolates
    Sandra Mazzoli
    STDs Center, Santa Maria Annunziata Hospital, Florence, Italy
    Arch Ital Urol Androl 79:71-5. 2007
    b>Prostatitis is one of the most common illnesses in men aged < or = 50 with different clinical presentation such as pelvic pain, Lower Urinary Tract Symptoms or sexual disfunction...
  86. ncbi Studies on antibacterial, anti-inflammatory and antioxidant activity of herbal remedies used in the treatment of benign prostatic hyperplasia and prostatitis
    V Steenkamp
    Department of Urology, Faculty of Health Sciences, University of Pretoria, South Africa
    J Ethnopharmacol 103:71-5. 2006
    ..remedies reported in the literature for traditional treatment of benign prostatic hyperplasia (BPH) and/or prostatitis were investigated for their effect on hydroxyl scavenging activity, antibacterial activity and their ability to ..
  87. ncbi Clinical significance of nontraditional bacterial uropathogens in the management of chronic prostatitis
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston, Ontario, Canada
    J Urol 179:1391-5. 2008
    We compared the clinical benefits of eradicating traditional accepted uropathogens and nontraditional uropathogens (gram-positive bacteria other than enterococci) in prostate specific specimens in men with clinical prostatitis.
  88. pmc High frequency of chronic bacterial and non-inflammatory prostatitis in infertile patients with prostatitis syndrome plus irritable bowel syndrome
    Enzo Vicari
    Section of Endocrinology, Andrology and Internal Medicine, Department of Internal Medicine and Systemic Diseases, University of Catania, Catania, Italy
    PLoS ONE 6:e18647. 2011
    Although prostatitis syndrome (PS) and irritable bowel syndrome (IBS) are common disorders, information on the prevalence of IBS in infertile patients with PS is relatively scanty...
  89. ncbi Epidemiology of prostatitis: new evidence for a world-wide problem
    John N Krieger
    Department of Urology, University of Washington School of Medicine, VAPSHCS 112 GU, 1600 South Columbian Way, Seattle, WA 98108, USA
    World J Urol 21:70-4. 2003
    We review new data on the epidemiology of chronic prostatitis. These population-based studies used reasonable case-definitions to survey various populations from North America, Europe and Asia...
  90. ncbi Serum prostate-specific antigen levels in Middle Eastern men with subclinical prostatitis
    J T Anim
    Department of Pathology, Faculty of Medicine, Kuwait University, Kuwait
    Med Princ Pract 16:53-8. 2007
    To investigate the influence of subclinical or histologically diagnosed prostatitis on serum prostate-specific antigen (PSA) in patients investigated for prostatic disease in Kuwait.
  91. ncbi Quality of life and psychological factors in chronic prostatitis/chronic pelvic pain syndrome
    Ja Hyeon Ku
    Department of Urology, Seoul Veterans Hospital, Seoul, Korea
    Urology 66:693-701. 2005
  92. ncbi A prospective, 1-year trial using saw palmetto versus finasteride in the treatment of category III prostatitis/chronic pelvic pain syndrome
    Steven A Kaplan
    Department of Urology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Urol 171:284-8. 2004
    This study was designed to assess the safety and efficacy of saw palmetto or finasteride in men with category III prostatitis/chronic pelvic pain syndrome (CP/CPPS).
  93. pmc Association between chronic prostatitis/chronic pelvic pain syndrome and anxiety disorder: a population-based study
    Shiu Dong Chung
    Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwan
    PLoS ONE 8:e64630. 2013
    This case-control study utilized a population-based dataset to examine the association of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) with prior anxiety disorder (AD) by comparing the risk of prior AD between subjects with ..
  94. ncbi Recommendations for the evaluation of patients with prostatitis
    J Curtis Nickel
    Department of Urology, Queen s University, Kingston General Hospital, Kingston, ON K7L 2V7, Canada
    World J Urol 21:75-81. 2003
    b>Prostatitis is a prevalent, confusing and frustrating clinical presentation for urologists. Three recent international and North American consensus meetings have drafted suggestions for the evaluation of a man presenting with prostatitis...
  95. pmc Fluoroquinolone-macrolide combination therapy for chronic bacterial prostatitis: retrospective analysis of pathogen eradication rates, inflammatory findings and sexual dysfunction
    Vittorio Magri
    Urology and Sonography Secondary Care Clinic, Azienda Ospedaliera Istituti Clinici di Perfezionamento, Milano 20132, Italy
    Asian J Androl 13:819-27. 2011
    ..the safety and efficacy of fluoroquinolone-macrolide combination therapy in category II chronic bacterial prostatitis (CBP)...
  96. ncbi Prostatein or steroid binding protein (PSBP) induces experimental autoimmune prostatitis (EAP) in NOD mice
    Virginia Rivero
    Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina
    Clin Immunol 105:176-84. 2002
    ..both spontaneous and induced autoimmune lesions, are susceptible to the induction of experimental autoimmune prostatitis (EAP), developing a severe inflammatory reaction in the prostate, accompanied by humoral and T-cell-mediated ..
  97. ncbi Role of mepartricin in category III chronic nonbacterial prostatitis/chronic pelvic pain syndrome: a randomized prospective placebo-controlled trial
    Aldo Franco De Rose
    Luciano Giuliani Urology Department, University of Genoa, Genoa, Italy
    Urology 63:13-6. 2004
    ..efficacy of mepartricin versus placebo with regard to symptom improvement in patients with chronic nonbacterial prostatitis/chronic pelvic pain syndrome (CPPS) and to verify a relation between hormonal levels and clinical improvement ..
  98. ncbi Symptoms and inflammation in chronic prostatitis/chronic pelvic pain syndrome
    John N Krieger
    Department of Urology, School of Medicine, University of Washington, Seattle, Washington, USA
    Urology 60:959-63. 2002
    To evaluate the possibility that patients with inflammatory and noninflammatory chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) might present with different symptoms...
  99. ncbi Prostatitis-like symptoms: one year later
    J C Nickel
    Department of Urology, Queen s University, Kingston, Ontario, Canada
    BJU Int 90:678-81. 2002
    ..as having perineal and/or ejaculatory pain/discomfort severe enough to suggest a clinical diagnosis of chronic prostatitis (using the National Institutes of Health-Chronic Prostatitis Symptom Index, NIH-CPSI), and to compare them with ..
  100. ncbi Prostatitis, interstitial cystitis, chronic pelvic pain, and urethral syndrome share a common pathophysiology: lower urinary dysfunctional epithelium and potassium recycling
    C Lowell Parsons
    Division of Urology, Department of Surgery, University of California, San Diego, Medical Center, 92103 8897, USA
    Urology 62:976-82. 2003
  101. ncbi Quercetin for chronic prostatitis/chronic pelvic pain syndrome
    Daniel A Shoskes
    Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Desk Q10 1, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Urol Clin North Am 38:279-84. 2011
    Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common condition with a heterogeneous origin that responds best to multimodal therapy...

Research Grants63

  1. VIRULENCE FACTORS OF CHLAMYDIAE
    PRISCILLA WYRICK; Fiscal Year: 2009
    ..in the USA and worldwide, of bacterially acquired sexually transmitted diseases and their sequelae, including prostatitis, epididymitis, pelvic inflammatory disease, ectopic pregnancy and sterility...
  2. Advanced Nitric Oxide Release Bactericidal Urinary Catheters
    Mark E Meyerhoff; Fiscal Year: 2013
    ..28 days, 100% long term) leading to complications such as cystitis, pyelonephritis, gram-negative bacteremia, prostatitis, epididymitis, urosepsis, septicemia, orchitis, endocarditis, vertebral osteomyelitis, septic arthritis, ..
  3. Rho-Modifying Cytotoxic Necrotizing Factor of E. coli
    ALISON DAVIS O'BRIEN; Fiscal Year: 2013
    ..e., cystitis or pyelonephritis, or acute prostatitis. In fact, the cnf1 locus and a hly operon are co-transcribed and co-regulated from a prototypic uropathogenic E...
  4. FUNCTION OF THE ENTERIC NERVOUS SYSTEM
    JACKIE WOOD; Fiscal Year: 2013
    ..g., interstitial cystitis, prostatitis, vulvodynia and fibromyalgia)...
  5. Cholesterol and Prostate Health
    Michael R Freeman; Fiscal Year: 2013
    ..applicant): The origin of benign prostatic disease, such as benign prostatic hyperperplasia (BPH) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), is poorly understood...
  6. Development of Nonhuman Primate Models for PSA Biology Studies
    JAMES NKAMBWE MUBIRU; Fiscal Year: 2013
    Common prostatic diseases include prostate cancer, benign prostatic hyperplasia (BPH) and prostatitis. These diseases are a cause of significant mortality and morbidity...
  7. Mapping serotonin receptors in lower urinary tract innervation
    E Michelle Southard-Smith; Fiscal Year: 2013
    ..floor is a defining feature of chronic pelvic pain syndromes including Interstitial Cystitis and Chronic Prostatitis. The causative pathology of these disorders is not known despite efforts to identify disease markers...
  8. Multi-Disciplinary Evaluation of Chronic Pelvic Pain Syndrome
    GERALD LOUIS ANDRIOLE; Fiscal Year: 2012
    ..Our understanding of (UCPPS) such as interstitial cystitis/painful bladder syndrome (IC/PBS) and chronic prostatitis/chronic pelvic pain syndrome, (CP/CPPS) is poor...
  9. Energy Balance-Related Hormones &Prostate Cancer Incidence &Progression
    Edward Giovannucci; Fiscal Year: 2012
    ..to SNS activity that disassociates high energy intake from weight gain and which is associated with chronic prostatitis/chronic pelvic pain syndrome prostatitis are at increased risk of prostate cancer...
  10. A Novel Surface Sensing Pathway in Proteus mirabilis
    Philip N Rather; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Urinary tract infections, including prostatitis and infectious urinary stones, affect a large percentage of our veteran population...
  11. Initiation and Regulation of Chronic Autoimmune Prostate Inflammation
    Timothy L Ratliff; Fiscal Year: 2013
    ..non-bacterial inflammation of the prostate is associated with multiple prostate diseases including chronic prostatitis-chronic pelvic pain syndrome (CP-CPPS), benign prostatic hyperplasia (BPH), and prostate cancer...
  12. Glycoproteins and Glycan-Binding IgGs: Biomarkers for Cancer and Inflammatory Di
    Hyesook Kim; Fiscal Year: 2013
    ..from cancer-free individuals had PSA levels higher than 4 ng/ml (false PSA positives) probably due to BPH or prostatitis. Moreover, ~75% of biopsy samples of individuals with PSA levels between 4 - 10 ng/ml were tumor negative...
  13. Role of Inflammation and Epigenetics in Benign Prostate Pathology
    Charles J Bieberich; Fiscal Year: 2012
    ..provided by applicant): Lower urinary tract symptoms associated with benign prostatic hyperplasia and prostatitis have a profound impact on quality of life...
  14. Auto-antibody plus PSA assay for patients with prostate cancer
    Gang Zeng; Fiscal Year: 2010
    ..Serum sample from 75 subjects in each cohort of healthy donors, BPH patients, patients with prostatitis as well as prostate cancer patients will be available for the proposed study...
  15. Advancing research on the sexually transmitted female 'nuisance' pathogen Trichom
    Jane Carlton; Fiscal Year: 2010
    ..parasite resides in the urogenital tract of both sexes and can cause vaginitis in women and urethritis and prostatitis in men...
  16. Chemokine Mechanisms in Chronic Pelvic Pain
    Praveen Thumbikat; Fiscal Year: 2013
    ..pelvic pain is the hallmark of patients with chronic pelvic pain syndrome (CPPS), a non- bacterial category of prostatitis that is a significant source of morbidity in American men...
  17. PROSAPOSIN, A NOVEL INFLAMMATORY RESPONSE FACTOR FOR PROSTATE CANCER PROGRESSION
    Shahriar Koochekpour; Fiscal Year: 2011
    ..Chronic prostatitis, triggered by an infectious process, has been suggested as a promoter of prostate carcinogenesis and prostate ..
  18. T cells in Chronic Pelvic Pain
    Praveen Thumbikat; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic pelvic pain is the hallmark of patients with Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), a category of prostatitis that is a significant source of morbidity in American men...
  19. Urinary Biomarkers of Lower Urinary Traxct Symptoms (LUTS) in Men
    WADE A BUSHMAN; Fiscal Year: 2013
    ..comparative studies to identify biomarker similarities among human LUTS patients, mice with bacterial prostatitis, and mice with hormone-induced urinary obstruction...
  20. Sensory Sensitivity and Urinary Symptoms in the Female Population
    Barbara D Reed; Fiscal Year: 2011
    ..used to describe these symptoms include interstitial cystitis (IC), painful bladder syndrome (PBS), chronic prostatitis, and overactive bladder (OAB), but there is tremendous overlap between these entities, and the distinction ..
  21. Limited Competition of the MAPP Research Network Data Coordinating Core (U01)
    J Richard Landis; Fiscal Year: 2013
    ..org), 6 including urology co-investigators with extensive expertise in chronic pelvic pain, chronic 7 prostatitis, and interstitial cystitis...
  22. Alternative Therapies for BPH, Multiethnic Variability
    Steven A Kaplan; Fiscal Year: 2010
    ..Erectile and ejaculatory function, ICSmale Incontinence scale, Jenkins Sleep Dysfunction scale and NIH Chronic Prostatitis Symptom Index;and to assess the impact of the assigned treatments on conhplete blood counts and basic blood ..
  23. Prostatitis and Prostate Cancer Development
    Lawrence Fong; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Prostatitis and prostate cancer are extremely common diseases in men, but the relationship between these two diseases is unknown...
  24. Interactive Mechanisms of Pelvic Pain
    David J Klumpp; Fiscal Year: 2012
    ..KEY ABBREVIATIONS SCPP = Syndromes of Chronic Pelvic Pain UCPPS = Urological Chronic Pelvic Pain Syndromes IBS = Irritable Bowel Syndrome CP = Chronic Prostatitis
  25. Role of TRPA1 &TRPV1 in pain and voiding symptoms in a new mouse CP/CPPS model
    Charles J Bieberich; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) affects as many as 16% of men and has enormous quality of life and economic consequences...
  26. Intravesical Drug Delivery Device
    Michael J Cima; Fiscal Year: 2010
    ..diseases such as overactive bladder (OAB), interstitial cystitis/painful bladder syndrome (IC/PBS), chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), and superficial bladder cancer...
  27. Role of Pattern Recognition Receptors in Prostate Epithelial Inflammation
    Praveen Thumbikat; Fiscal Year: 2013
    ..coli. In vitro culture models and a novel in vivo murine bacterial prostatitis model will be used...
  28. Anti-GM1b IgM for Detection of Localized Prostate Cancer
    Mepur Ravindranath; Fiscal Year: 2005
    ..Moreover, benign prostatic hyperplasia (BPH) and prostatitis can falsely elevate serum PSA...
  29. REGULATION OF E-SELECTIN DURING ACUTE INFLAMMATION
    Kevin Billups; Fiscal Year: 1999
    ..Examples of specific disorders include: pyelonephritis, cystitis, epididymitis, orchitis, and prostatitis. In addition to acute infectious etiologies, it is becoming increasingly clear that ischemia/reperfusion injury ..
  30. Interstitial Cystitis Clinical Research Network
    Christopher Payne; Fiscal Year: 2007
    ..group at Stanford will work in parallel with the centers conducting trials for investigation of chronic prostatitis. A simultaneous application for that effort is being submitted. This is a critical juncture for IC research...
  31. CHRONIC PROSTATITIS COLLABORATIVE CLINICAL RESEARCH
    Anthony Schaeffer; Fiscal Year: 1999
    DESCRIPTION (Taken from the applicant's Abstract) Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CPPS) affects men of all ages. Cytokines are important inflammatory mediators...
  32. CHRONIC PROSTATITIS CLINICAL RESEARCH CENTER
    Michel Pontari; Fiscal Year: 1999
    ..to validate survey and laboratory diagnostic tools for clinical study protocols of men with category III prostatitis. This is a proposal to be chosen as one of the clinical centers carrying out these studies...
  33. Healing Chronic Wounds by Controlling Microbial Biofilm
    Philip Stewart; Fiscal Year: 2009
    ..Furthermore, the results of this research may impact the treatment of other biofilm-related diseases, such as osteomyelitis, endocarditis, prostatitis, otitis media, and sinusitis.
  34. MR Based Molecular Imaging of Prostate Cancer
    John Kurhanewicz; Fiscal Year: 2009
    ..increasing Gleason score, prostatic intraepithelial neoplasia (PIN), prostatic inflammatory atrophy (PIA) and prostatitis. (2) The dramatic decreases in prostate citrate levels with prostate cancer evolution, progression, and in ..
  35. ATRAZINE: IMPACT ON ENVIRONMENTAL AND PUBLIC HEALTH
    Tyrone Hayes; Fiscal Year: 2004
    ..Several studies have suggested that atrazine induces mammary tumors, prostate cancer, and prostatitis in rodents in addition to other adverse effects on reproduction...
  36. BIOSTATISTICS SUPPORT CENTER FOR CHRONIC PROSTATITIS
    J Landis; Fiscal Year: 2000
    ..University of Pennsylvania Medical Center to serve as the Biostatistics Support Center (BSC) for the Chronic Prostatitis Clinical Research Group (CPCRG)...
  37. PROGRESSION OF BPH ON MEDICAL THERAPY
    Steven Kaplan; Fiscal Year: 2001
    ..various forms of BPH resulting in different rates of progression and differential response to therapy? and, E) whether concomitant prostate conditions such as cancer or prostatitis are effected by pharmacologic intervention for BPH?
  38. CHRONIC PROSTATITIS COLLABORATIVE CLINICAL RESEARCH STUD
    Mark Litwin; Fiscal Year: 1999
    DESCRIPTION (Taken from the applicant's Abstract) Chronic non-infectious prostatitis or chronic pelvic pain syndrome (CPPS) represents one of the greatest challenges in clinical medicine...
  39. IMMUNOLOGIC THERAPY OF PROSTATE CANCER
    Gurkamal Chatta; Fiscal Year: 2001
    ..Others have shown that immunizing rodents to homogenate prostate tissue can induce T cell mediated autoimmune prostatitis. However, the target antigens are unknown, and the autoimmunity has been observed to be self limited...
  40. MULTISPECTRAL BACTERIAL IDENTIFICATION
    STEVEN ROBLES; Fiscal Year: 2002
    ..Using this integrated identification protocol, bacteria that may be associated with chronic conditions (e.g., prostatitis and vaginosis) will be identified first by analyzing their 16S rDNA sequences and then by visualizing them with ..
  41. ACTIVATION OF PROSTATE SPECIFIC ANTIGEN PRECURSOR
    Thomas Takayama; Fiscal Year: 2000
    ..bradykinin stimulates inflammatory response, there may be a potential role of PSA in the pathogenesis of prostatitis. Our hypothesis therefore, is that PSA, and other serine proteases of the prostate, may be involved in the ..
  42. Effects of Stretch on IC and Normal Urothelia
    Toby Chai; Fiscal Year: 2005
    ..2. Male patients with chronic non-bacterial prostatitis (prostatitis class III or chronic pelvic pain syndrome, CPPS) and NISC have post-hydrodistention glomerulations ..
  43. CHARACTERIZATION & TREATMENT OF CATEGORY III PROSTATITIS
    J Nickel; Fiscal Year: 1999
    DESCRIPTION (Taken from the applicant's Abstract) Characterization and Treatment of Category III Prostatitis Background: Chronic abacterial prostatitis and prostatodynia (NIH Category III), remains a frustrating enigma for North American ..
  44. CHRONIC PROSTATITIS COLLABORATIVE CLINICAL STUDIES
    Richard Alexander; Fiscal Year: 1999
    DESCRIPTION (Taken from the applicant's Abstract) Chronic non-bacterial prostatitis is perhaps the most common diagnosis of men in the United States who seek the care of a urologist, yet almost nothing is known about the etiology of the ..
  45. Interstitial Cystitis Clinical Research Network
    David Burks; Fiscal Year: 2007
    ..The ICCRN will work in collaboration with the Chronic Prostatitis Clinical Research Network to investigate interstitial cystitis as a subset of chronic pelvic pain disorders of ..
  46. Interstitial Cystitis Clinical Research Network (ICCRN)
    Karl Kreder; Fiscal Year: 2007
    ..will participate in the Urologic-Chronic Pelvic Pain Syndromes Collaborative Group to conduct trials in chronic prostatitis. A concept protocol using low dose BCG and interferon-alpha(alpha) is included in this proposal...
  47. Interstitial Cystitis Clinical Research Network (ICCRN)
    Grannum Sant; Fiscal Year: 2003
    ..e) coordinate protocol development and clinical outcomes analyses with the Chronic Prostatitis Clinical Research Network (CPCRN) under the umbrella of the Urological Chronic Pain Syndromes Collaborative ..
  48. BIOFEEDBACK SYSTEM FOR URINARY AND FECAL INCONTINENCE
    EDWARD MC GOWAN; Fiscal Year: 1992
    ..3. Develop other applications, such as : Irritable Bowel Syndrome, Prostatitis, and Sexual Function for this system...
  49. Chronic Prostatitis Collaborative Clinical Trials
    Mary McNaughton Collins; Fiscal Year: 2007
    ..General Hospital (MGH) / Harvard Medical School to become one of the Clinical Centers of the Chronic Prostatitis Collaborative Research Network (CPCRN) to develop and conduct randomized clinical trials for evaluating novel ..
  50. CHARACTERIZATION & TREATMENT OF CATEGORY III PROSTATITIS
    J Nickel; Fiscal Year: 2003
    DESCRIPTION (Taken from the applicant's Abstract) Characterization and Treatment of Category III Prostatitis Background: Chronic abacterial prostatitis and prostatodynia (NIH Category III), remains a frustrating enigma for North American ..
  51. Interstitial Cystitis Clinical Research Network (ICCRN)
    J Nickel; Fiscal Year: 2007
    ..The interstitial cystitis research group is closely affiliated with the Queen's University Prostatitis Research Group (PI Dr. J.C. Nickel) which is collaborating in the NIH CPCRN (including CPCRN RCT#1)...
  52. CHRONIC PROSTATITIS COLLABORATIVE CLINICAL STUDIES
    MICHAEL O LEARY; Fiscal Year: 1999
    ..This proposal describes an integrated, multidisciplinary and collaborative approach to studying chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), a common yet poorly understood condition, in a spectrum of men from ..
  53. Chronic Prostatitis Collaborative Research Network CPCRN
    J Nickel; Fiscal Year: 2007
    ..The Queen's University Prostatitis Research Group was established under the directorship of Dr. J...
  54. Becoming a member of the CPCRN-for prostatitis
    Richard Berger; Fiscal Year: 2005
    ..manner; (3) develop and conduct ancillary studies, which will provide further understanding of chronic prostatitis. Subjects will be recruited from the practice of Dr...
  55. MECHANISMS OF CHRONIC PROSTATITIS
    Don Kreutzer; Fiscal Year: 2000
    ..is known about the existence and role of T lymphocytes, mast cells and their products in non bacterial chronic prostatitis (NBCP)...
  56. Data Coordinating Center for CPCRN and ICCRN
    J Landis; Fiscal Year: 2007
    ..at the University of Pennsylvania Medical Center to serve as the Data Coordinating Center (DCC) for the Chronic Prostatitis Collaborative Research Network (CPCRN) and the Interstitial Cystitis Clinical Research Network (ICCRN)...
  57. Biomarkers for prostate cancer risk assessment
    Srinivasa Nagalla; Fiscal Year: 2006
    ..PSA levels that are due to factors other than prostate cancer, such as benign prostatic hyperplasia (BPH), prostatitis, etc...
  58. REGULATORY MECHANISMS OF PROSTATE TUMOR PROGRESSION
    Warren Heston; Fiscal Year: 2002
    Abnormal conditions or the prostate constitute a major medical problem in the United States. Prostatitis, benign enlargement (BPH), and malignant growth of the prostate (CaP), will effect the lives of most men over the age of 50...
  59. Diagnostic Challenges in IC (and Male CPPS)
    Jordan Dimitrakov; Fiscal Year: 2007
    The etiology and pathogenesis of interstitial cystitis (IC) and its related condition in men, chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) has remained elusive...
  60. Chronic Prostatitis Collaborative Research Network
    Michel Pontari; Fiscal Year: 2007
    ..to develop and conduct randomized clinical trials to evaluate novel therapies in patients with category III prostatitis. The research group will conduct ancillary studies to investigate the etiology and pathogenesis of chronic ..
  61. Urological Studies of Ideopathic Lower Tract Syndrome
    JOHN KRIEGER; Fiscal Year: 2005
    b>Prostatitis syndromes cause major morbidity with a 10 percent prevalence among adult men. This project focuses on the most common category, chromc prostatitis/chronic pelvic pain syndrome (CP/CPPS)...
  62. UW/USM Chronic Prostatitis CRC
    JOHN KRIEGER; Fiscal Year: 2007
    b>Prostatitis is a chronic, disabling condition affecting untold numbers of men of all ages and ethnic origins. We will participate in the Chronic Prostatitis Collaborative Research Network (CPCRN)...
  63. MALE GENITAL TRACT RESERVOIRS AND VIRAL SHEDDING
    JOHN KRIEGER; Fiscal Year: 2004
    ..Thus, controlling one genital tract virus may limit viral-viral interactions, reduce the viral burden in semen, and decrease the sexual transmission of other viruses. ..