pulpitis

Summary

Summary: Inflammation of the DENTAL PULP, usually due to bacterial infection in dental caries, tooth fracture, or other conditions causing exposure of the pulp to bacterial invasion. Chemical irritants, thermal factors, hyperemic changes, and other factors may also cause pulpitis.

Top Publications

  1. ncbi Histological analysis of rat dental pulp tissue capped with propolis
    Ardo Sabir
    Department of Conservative Dentistry, Faculty of Dentistry, Hasanuddin University, Makassar 90245, Indonesia
    J Oral Sci 47:135-8. 2005
  2. ncbi The effect of pulpotomy using a calcium-enriched mixture cement versus one-visit root canal therapy on postoperative pain relief in irreversible pulpitis: a randomized clinical trial
    Saeed Asgary
    Iranian Center for Endodontic Research, Dental Research Center, Dental School, Shahid Beheshti Medical University, Evin, Tehran, 1983963113, Iran
    Odontology 98:126-33. 2010
  3. doi MTA pulpotomy of human permanent molars with irreversible pulpitis
    Mohammad Jafar Eghbal
    Department of Endodontics, Iranian Center for Endodontic Research, Dental Research Center, Shahid Beheshti University M C, Tehran, Iran
    Aust Endod J 35:4-8. 2009
  4. ncbi Articaine for supplemental intraosseous anesthesia in patients with irreversible pulpitis
    Jason Bigby
    Section of Endodontics, College of Dentistry, The Ohio State University, Columbus, Ohio 43218, USA
    J Endod 32:1044-7. 2006
  5. ncbi Anesthetic efficacy of articaine for inferior alveolar nerve blocks in patients with irreversible pulpitis
    Elizabeth Claffey
    Department of Oral Surgery, Oral Pathology, and Anesthesiology, The Ohio State University, Columbus, OH 43218, USA
    J Endod 30:568-71. 2004
  6. ncbi Anesthetic efficacy of the supplemental X-tip intraosseous injection in patients with irreversible pulpitis
    John Nusstein
    Department of Oral Biology, The Ohio State University, Columbus 43218, USA
    J Endod 29:724-8. 2003
  7. ncbi The significance of needle deflection in success of the inferior alveolar nerve block in patients with irreversible pulpitis
    Shawn Kennedy
    US Army, Fort Stewart, GA, USA
    J Endod 29:630-3. 2003
  8. doi Efficacy of combining a buccal infiltration with an inferior alveolar nerve block for mandibular molars with irreversible pulpitis
    Masoud Parirokh
    Neuroscience Research Center, Oral and Dental Research Center, Kerman University of Medical Sciences, Kerman, Iran
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:468-73. 2010
  9. doi Comparison of anesthetic efficacy of 4% articaine and 2% lidocaine for maxillary buccal infiltration in patients with irreversible pulpitis
    Narasimhan Srinivasan
    Department of Conservative Dentistry, Tamilnadu Government Dental College and Hospital, Chennai 3, India
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107:133-6. 2009
  10. ncbi Articaine for supplemental buccal mandibular infiltration anesthesia in patients with irreversible pulpitis when the inferior alveolar nerve block fails
    Rachel Matthews
    Division of Endodontics, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA
    J Endod 35:343-6. 2009

Research Grants

  1. FACIAL BEHAVIOR RELATED TO ACUTE DENTAL PAIN
    Linda LeResche; Fiscal Year: 1990
  2. BioPulp: Bioengineeering approaches for dental pulp regeneration
    SUSAN FU; Fiscal Year: 2009
  3. DISTRIBUTION AND ULTRASTRUCTURE OF DENTAL INNERVATION
    MARGARET BYERS; Fiscal Year: 1993
  4. DISTRIBUTION AND ULTRASTRUCTURE OF DENTAL INNERVATION
    MARGARET BYERS; Fiscal Year: 1992
  5. DISTRIBUTION AND ULTRASTRUCTURE OF DENTAL INNERVATION
    MARGARET BYERS; Fiscal Year: 1991
  6. DISTRIBUTION AND ULTRASTRUCTURE OF DENTAL INNERVATION
    MARGARET BYERS; Fiscal Year: 1990
  7. Sodium Channel Expression in Human Teeth
    Michael Henry; Fiscal Year: 2005
  8. Sodium Channel Expression in Human Teeth
    Michael Henry; Fiscal Year: 2006
  9. Sodium Channel Expression in Human Teeth
    Michael Henry; Fiscal Year: 2007
  10. Sodium Channel Expression in Human Teeth
    Michael Henry; Fiscal Year: 2009

Detail Information

Publications214 found, 100 shown here

  1. ncbi Histological analysis of rat dental pulp tissue capped with propolis
    Ardo Sabir
    Department of Conservative Dentistry, Faculty of Dentistry, Hasanuddin University, Makassar 90245, Indonesia
    J Oral Sci 47:135-8. 2005
    ..Partial dentinal bridge formation was seen in group II at week 4. Therefore, the present results suggest that direct pulp capping with propolis flavonoids in rats may delay dental pulp inflammation and stimulate reparative dentin...
  2. ncbi The effect of pulpotomy using a calcium-enriched mixture cement versus one-visit root canal therapy on postoperative pain relief in irreversible pulpitis: a randomized clinical trial
    Saeed Asgary
    Iranian Center for Endodontic Research, Dental Research Center, Dental School, Shahid Beheshti Medical University, Evin, Tehran, 1983963113, Iran
    Odontology 98:126-33. 2010
    ..with a new endodontic calcium-enriched mixture cement (PCEM) in human permanent molars with irreversible pulpitis. A total of 407 selected patients were randomly allocated into the ORCT group (n = 202) or the PCEM group (n = ..
  3. doi MTA pulpotomy of human permanent molars with irreversible pulpitis
    Mohammad Jafar Eghbal
    Department of Endodontics, Iranian Center for Endodontic Research, Dental Research Center, Shahid Beheshti University M C, Tehran, Iran
    Aust Endod J 35:4-8. 2009
    The histological success of mineral trioxide aggregate (MTA) pulpotomy for treatment of irreversible pulpitis in human teeth as an alternative treatment was investigated in this study...
  4. ncbi Articaine for supplemental intraosseous anesthesia in patients with irreversible pulpitis
    Jason Bigby
    Section of Endodontics, College of Dentistry, The Ohio State University, Columbus, Ohio 43218, USA
    J Endod 32:1044-7. 2006
    ..epinephrine for supplemental intraosseous injection in mandibular posterior teeth diagnosed with irreversible pulpitis. Thirty-seven emergency patients, diagnosed with irreversible pulpitis of a mandibular posterior tooth, received ..
  5. ncbi Anesthetic efficacy of articaine for inferior alveolar nerve blocks in patients with irreversible pulpitis
    Elizabeth Claffey
    Department of Oral Surgery, Oral Pathology, and Anesthesiology, The Ohio State University, Columbus, OH 43218, USA
    J Endod 30:568-71. 2004
    ..2% lidocaine with 1:100,000 epinephrine for inferior alveolar nerve blocks in patients experiencing irreversible pulpitis in mandibular posterior teeth...
  6. ncbi Anesthetic efficacy of the supplemental X-tip intraosseous injection in patients with irreversible pulpitis
    John Nusstein
    Department of Oral Biology, The Ohio State University, Columbus 43218, USA
    J Endod 29:724-8. 2003
    ..using the X-tip system in an apical location, in mandibular posterior teeth diagnosed with irreversible pulpitis when the conventional inferior alveolar nerve block failed...
  7. ncbi The significance of needle deflection in success of the inferior alveolar nerve block in patients with irreversible pulpitis
    Shawn Kennedy
    US Army, Fort Stewart, GA, USA
    J Endod 29:630-3. 2003
    ..administered using the computer-assisted Wand II anesthesia system, in patients diagnosed with irreversible pulpitis. Sixty-four emergency patients diagnosed with irreversible pulpitis of a mandibular posterior tooth randomly ..
  8. doi Efficacy of combining a buccal infiltration with an inferior alveolar nerve block for mandibular molars with irreversible pulpitis
    Masoud Parirokh
    Neuroscience Research Center, Oral and Dental Research Center, Kerman University of Medical Sciences, Kerman, Iran
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:468-73. 2010
    The aim of this study was to assess the efficacy of inferior alveolar nerve (IAN) block combined with buccal infiltration for mandibular molars with irreversible pulpitis.
  9. doi Comparison of anesthetic efficacy of 4% articaine and 2% lidocaine for maxillary buccal infiltration in patients with irreversible pulpitis
    Narasimhan Srinivasan
    Department of Conservative Dentistry, Tamilnadu Government Dental College and Hospital, Chennai 3, India
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107:133-6. 2009
    ..randomized, double-blind study was to compare the anesthetic efficacy of 4% articaine and 2% lidocaine (both with 1:100,000 epinephrine) for buccal infiltration in patients experiencing irreversible pulpitis in maxillary posterior teeth.
  10. ncbi Articaine for supplemental buccal mandibular infiltration anesthesia in patients with irreversible pulpitis when the inferior alveolar nerve block fails
    Rachel Matthews
    Division of Endodontics, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA
    J Endod 35:343-6. 2009
    ..a cartridge of 4% articaine with 1:100,000 epinephrine in mandibular posterior teeth diagnosed with irreversible pulpitis when the conventional inferior alveolar nerve (IAN) block failed...
  11. ncbi The effect of preoperative acetaminophen or a combination of acetaminophen and Ibuprofen on the success of inferior alveolar nerve block for teeth with irreversible pulpitis
    Staci R Ianiro
    Department of Endodontics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Endod 33:11-4. 2007
    ..There were 40 patients with irreversible pulpitis randomly assigned to a drug or placebo group...
  12. ncbi A six year evaluation of cracked teeth diagnosed with reversible pulpitis: treatment and prognosis
    Keith V Krell
    Department of Endodontics, College of Dentistry, University of Iowa, Iowa City, Iowa, USA
    J Endod 33:1405-7. 2007
    ..The purpose of this investigation was to report on the clinical outcomes of cracked teeth diagnosed with reversible pulpitis (RP)...
  13. doi Effect of sublingual triazolam on the success of inferior alveolar nerve block in patients with irreversible pulpitis
    Matthew Lindemann
    Private Practice Limited to Endodontics, Flint, Michigan, USA
    J Endod 34:1167-70. 2008
    ..triazolam on the success of the inferior alveolar nerve (IAN) block in patients experiencing irreversible pulpitis. Fifty-eight emergency patients diagnosed with irreversible pulpitis of a mandibular posterior tooth randomly ..
  14. ncbi Measurement of mechanical allodynia and local anesthetic efficacy in patients with irreversible pulpitis and acute periradicular periodontitis
    Asma A Khan
    Department of Endodontics, University of Texas Health Science Center, San Antonio, Texas, USA
    J Endod 33:796-9. 2007
    ..Mechanical pain thresholds were measured in patients (n = 30) with irreversible pulpitis (IP) and APP and compared with their contralateral teeth...
  15. ncbi Anesthetic efficacy of lidocaine/meperidine for inferior alveolar nerve blocks in patients with irreversible pulpitis
    Jason Bigby
    Department of Endodontics, College of Dentistry, The Ohio State University, Columbus, Ohio, USA
    J Endod 33:7-10. 2007
    ..for inferior alveolar nerve blocks (IAN) in patients with mandibular posterior teeth experiencing irreversible pulpitis. Forty-eight emergency patients diagnosed with irreversible pulpitis of a mandibular posterior tooth randomly ..
  16. ncbi Innate immune responses of the dental pulp to caries
    Chin Lo Hahn
    Department of Endodontics, School of Dentistry, Virginia Commonwealth University, 520 North 12th Street, Richmond, Virginia 3298 0566, USA
    J Endod 33:643-51. 2007
    ..Summaries of innate immune cells as well as their cytokines and chemokines in healthy and reversible pulpitis tissues are presented.
  17. ncbi The incidence of mechanical allodynia in patients with irreversible pulpitis
    Christopher B Owatz
    Department of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Endod 33:552-6. 2007
    The mechanisms of odontogenic pain are complex and incompletely understood. Cases of irreversible pulpitis are thought to represent a localized inflammatory response to bacterial challenge in dental pulp tissue...
  18. doi The prevalence of secondary dentinal lesions in cheek teeth from horses with clinical signs of pulpitis compared to controls
    M B Casey
    Equine Diagnostic Centre, University of Bristol, Langford House, Langford, Bristol BS40 5DU, UK
    Equine Vet J 42:30-6. 2010
    ..More information regarding the association of secondary dentinal defects with apical dental disease would improve the sensitivity of oral examination as a diagnostic aid for pulpitis.
  19. doi Delayed partial pulpotomy in a midroot and complicated crown-root-fractured permanent incisor with hyperplastic pulpitis: a case report
    Mehmet Kemal Calişkan
    Department of Endodontics, Ege University, Izmir, Turkey
    J Endod 36:1250-3. 2010
    ..The occurrence of multiple injuries of the same tooth is extremely rare. This case report describes the treatment in a midroot and complicated crown-root-fractured permanent incisor that remained untreated for 4 years after the accident...
  20. ncbi A real time quantitative PCR analysis and correlation of COX-1 and COX-2 enzymes in inflamed dental pulps following administration of three different NSAIDs
    Claudia I Holt
    Department of Endodontics and Periodontics, University of Texas Dental, Branch at Houston, Houston, Texas, USA
    J Endod 31:799-804. 2005
    ..However, Vioxx and Advil significantly reduced COX-2 expression levels compared to inflamed (positive control) pulps (p < 0.05)...
  21. doi A comparison of the anesthetic efficacy of articaine and lidocaine in patients with irreversible pulpitis
    Isabel Peixoto Tortamano
    Department of Stomatology, School of Dentistry, Federal University of São Paulo USP, Sao Paulo, SP, Brazil
    J Endod 35:165-8. 2009
    ..epinephrine with that of 2% lidocaine with 1:100,000 epinephrine during pulpectomy in patients with irreversible pulpitis in mandibular posterior teeth...
  22. ncbi [Padma 28 in the treatment of chronic dental pulpitis: an observational case study in 49 patients]
    Fritz Füllemann
    Private Praxis, Kronbühl, Schweiz
    Forsch Komplementmed 13:28-30. 2006
    In the case of pulpitis the dentist has to differentiate between a reversible and therefore treatable pulpal inflammation and an irreversible damage of the pulpa, accord-ing to the clinical symptoms...
  23. pmc Lipopolysaccharide-induced pulpitis up-regulates TRPV1 in trigeminal ganglia
    M K Chung
    University of Maryland Baltimore School of Dentistry, Program in Neuroscience, Department of Neural and Pain Sciences, 650 W Baltimore Street, Baltimore, MD 21201, USA
    J Dent Res 90:1103-7. 2011
    Tooth pain often accompanies pulpitis. Accumulation of lipopolysaccharides (LPS), a product of Gram-negative bacteria, is associated with painful clinical symptoms...
  24. doi Pattern-recognition receptors in pulp defense
    M J Staquet
    Odontoblastes et Régénération des Tissus Dentaires, Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, CNRS, INRA, Ecole Normale Superieure de Lyon, France
    Adv Dent Res 23:296-301. 2011
    ....
  25. ncbi Anesthetic effectiveness of the supplemental intraligamentary injection, administered with a computer-controlled local anesthetic delivery system, in patients with irreversible pulpitis
    John Nusstein
    Department of Endodontics, The Ohio State University, Columbus, Ohio 43218, USA
    J Endod 31:354-8. 2005
    ..a computer-controlled local anesthetic delivery system, in mandibular posterior teeth diagnosed with irreversible pulpitis when the conventional inferior alveolar nerve block failed...
  26. ncbi Histology of Irreversible pulpitis premolars treated with mineral trioxide aggregate pulpotomy
    Ling Huey Chueh
    Elite Dental Clinic, Taipei, Taiwan
    Oper Dent 35:370-4. 2010
    ..In this case report, a 19-year-old female patient with a second premolar with irreversible pulpitis and symptomatic apical periodontitis was treated with MTA pulpotomy...
  27. doi Effect of combination of preoperative ibuprofen/acetaminophen on the success of the inferior alveolar nerve block in patients with symptomatic irreversible pulpitis
    Michael Simpson
    The Ohio State University, Columbus, OH, USA
    J Endod 37:593-7. 2011
    ..study was to determine the effect of the administration of the combination of preoperative ibuprofen/acetaminophen on the success of the inferior alveolar nerve (IAN) block in patients with symptomatic irreversible pulpitis.
  28. ncbi Anesthetic efficacy of supplemental buccal and lingual infiltrations of articaine and lidocaine after an inferior alveolar nerve block in patients with irreversible pulpitis
    Vivek Aggarwal
    Department of Dental Surgery, Safdarjung Hospital, New Delhi, India
    J Endod 35:925-9. 2009
    The success rate of inferior alveolar nerve block (IANB) decreases in patients with irreversible pulpitis. It was hypothesized that supplemental infiltration of lidocaine and articaine may improve the success rates.
  29. doi Anesthetic efficacy of the Gow-Gates injection and maxillary infiltration with articaine and lidocaine for irreversible pulpitis
    Michael G Sherman
    Department of Endodontics, Nova Southeastern University, Fort Lauderdale, Florida 33328, USA
    J Endod 34:656-9. 2008
    ..1:100,000 epinephrine (LE) for Gow-Gates blocks and maxillary infiltrations in patients experiencing irreversible pulpitis in mandibular and maxillary posterior teeth...
  30. doi The effect of premedication with ibuprofen and indomethacin on the success of inferior alveolar nerve block for teeth with irreversible pulpitis
    Masoud Parirokh
    Oral and Dental Research Center, Kerman University of Medical Sciences, Kerman, Iran
    J Endod 36:1450-4. 2010
    Achieving pulp anesthesia with irreversible pulpitis is difficult. This study evaluated whether nonsteroidal anti-inflammatory drugs assist local anesthesia.
  31. doi Pulpitis increases the proportion of atypical nodes of Ranvier in human dental pulp axons without a change in Nav1.6 sodium channel expression
    S Luo
    Department of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Neuroscience 169:1881-7. 2010
    ..The resultant heterogeneous population of isoforms may produce unique axonal excitability properties that could contribute to spontaneous pain sensations that are common in toothache...
  32. ncbi Tissue levels of immunoreactive substance P are increased in patients with irreversible pulpitis
    Walter R Bowles
    Division of Endodontics, University of Minnesota School of Dentistry, Minneapolis 55455, USA
    J Endod 29:265-7. 2003
    ..In this study, we tested the hypothesis that irreversible pulpitis is associated with increased activity of peptidergic neurons, as measured by increased pulpal levels of ..
  33. doi Predictable management of cracked teeth with reversible pulpitis
    P Abbott
    School of Dentistry, Oral Health Centre of WA, The University of Western Australia, Nedlands WA
    Aust Dent J 54:306-15. 2009
    ..The aims of this study were to assess symptoms and signs caused by cracks in teeth and to assess a conservative management protocol...
  34. ncbi Effects of an inducible nitric oxide synthase inhibitor on experimentally induced rat pulpitis
    Hiromi Nakano Kawanishi
    Pulp Biology and Endodontics, Department of Restorative Sciences, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Eur J Oral Sci 112:332-7. 2004
    ..of an iNOS-specific inhibitor, N-(3-(aminomethyl)benzyl)acetamidine (1400W), on experimentally induced rat pulpitis in the upper incisors of 6-wk-old male Wistar rats...
  35. ncbi Irreversible but not reversible pulpitis is associated with up-regulation of tumour necrosis factor-alpha gene expression in human pulp
    A B Kokkas
    Department of Endodontology, School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Int Endod J 40:198-203. 2007
    ....
  36. ncbi Transforming growth factor-beta 1 (TGF-beta 1) expression in normal healthy pulps and in those with irreversible pulpitis
    A Piattelli
    Dental School, University of Chieti, Chieti, Italy
    Int Endod J 37:114-9. 2004
    To evaluate the Transforming Growth Factor-beta 1 (TGF-beta 1) expression in normal healthy pulps and in those with irreversible pulpitis.
  37. ncbi Evaluation of the effect of locally administered amitriptyline gel as adjunct to local anesthetics in irreversible pulpitis pain
    A A Moghadamnia
    Department of Pharmacology, Babol University of Medical Sciences, Babol, Iran
    Indian J Dent Res 20:3-6. 2009
    ..This study was designed to assess the additional analgesic effects of 2% Amitriptyline local gel administration in irreversible pulpitis pain of the molars.
  38. pmc Quantitative microbiological study of human carious dentine by culture and real-time PCR: association of anaerobes with histopathological changes in chronic pulpitis
    F Elizabeth Martin
    Institute of Dental Research, Westmead Centre for Oral Health, Westmead Hospital, P O Box 533, Wentworthville NSW 2145, Australia
    J Clin Microbiol 40:1698-704. 2002
    ..with the tissue response of the dental pulps of 65 teeth extracted from patients with advanced caries and pulpitis. Standardized homogenates of carious dentine were plated onto selective and nonselective media under anaerobic ..
  39. ncbi Success of an alternative for interim management of irreversible pulpitis
    Roger A McDougal
    Department of Endodontics, University of North Carolina at Chapel Hill School of Dentistry, USA
    J Am Dent Assoc 135:1707-12. 2004
    Extraction and endodontic therapy are treatment options for irreversible pulpitis. Extraction often is chosen for financial reasons. The authors conducted a study to investigate an alternative interim therapy.
  40. pmc TRPM8 Axonal expression is decreased in painful human teeth with irreversible pulpitis and cold hyperalgesia
    Lisa T Alvarado
    Department of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Endod 33:1167-71. 2007
    b>Pulpitis pain might be triggered by a cold stimulus, yet the cellular mechanisms responsible for this phenomenon are largely unknown. One possible mechanism involves the direct activation of cold-responsive thermoreceptors...
  41. ncbi Relationships between caries bacteria, host responses, and clinical signs and symptoms of pulpitis
    Chin Lo Hahn
    Department of Endodontics, School of Dentistry, Virginia Commonwealth University, Richmond, VA 23298 0566, USA
    J Endod 33:213-9. 2007
    ..inflammatory responses they elicit in the dental pulp is prerequisite to our understanding of the pathogenesis of pulpitis. Recent advances in immunology and neurophysiology can now explain some of the clinical manifestations of ..
  42. doi Herpesviruses in endodontic pathoses: association of Epstein-Barr virus with irreversible pulpitis and apical periodontitis
    Hong Li
    Department of Endodontology, Oregon Health and Science University, School of Dentistry, Portland, Oregon 97239, USA
    J Endod 35:23-9. 2009
    Irreversible pulpitis and apical periodontitis are inflammatory diseases caused by opportunistic bacteria with possible co-infection with latent herpesviruses...
  43. ncbi Long-term follow-up of composite resin restorations with self-etching adhesives
    Masako Unemori
    Department of Endodontology and Operative Dentistry, Faculty of Dental Science, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Dent 35:535-40. 2007
    ..To test the hypothesis, derived from a previous short-term (7-day) assessment, that the absence of conventional pulp protection is not responsible for long-term pulp complications of composite resin restorations with self-etching adhesives...
  44. ncbi Diagnosis dilemmas in vital pulp therapy: treatment for the toothache is changing, especially in young, immature teeth
    Joe H Camp
    Department of Endodontics, University of North Carolina, School of Dentistry, Chapel Hill, NC, USA
    Pediatr Dent 30:197-205. 2008
    ..The apical barrier with mineral trioxide aggregate followed by root strengthening with bonded composite is reviewed...
  45. ncbi Effects of hemostatic agents on the histomorphologic response of human dental pulp capped with calcium hydroxide
    Maria de Lourdes Rodrigues Accorinte
    Department of Dental Materials, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil
    Quintessence Int 38:843-52. 2007
    ..To evaluate the response of human pulps capped with a calcium hydroxide [Ca(OH)2] cement after bleeding control with 2 hemostatic agents...
  46. ncbi Clinical and histological evaluation of white ProRoot MTA in direct pulp capping
    Claudio E Iwamoto
    Department of Advanced Education in General Dentistry, Baltimore College of Dental Surgery, University of Maryland, USA
    Am J Dent 19:85-90. 2006
    ..To evaluate the clinical, radiographical and histological findings in human third molars in which mechanical pulp exposures were capped with white ProRoot mineral trioxide aggregate (WMTA)...
  47. ncbi Regenerative potential of dental pulp
    Martin Trope
    Department of Endodontics, University of North Carolina, School of Dentistry, Chapel Hill, NC, USA
    Pediatr Dent 30:206-10. 2008
    ..This article explores our knowledge in this regard and the future potential of saving or even regenerating the pulp as a routine dental procedure...
  48. ncbi Mineral trioxide aggregate pulpotomies: a case series outcomes assessment
    David E Witherspoon
    North Texas Endodontic Associates, Plano 75023, USA
    J Am Dent Assoc 137:610-8. 2006
    ..The authors describe the clinical and radiographic outcome of a series of cases involving the use of MTA in pulpotomy procedures...
  49. pmc The expression and role of stromal cell-derived factor-1alpha-CXCR4 axis in human dental pulp
    Long Jiang
    Department of General Dentistry, Ninth People s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Research Institute of Stomatology, Shanghai, China
    J Endod 34:939-44. 2008
    ..Taken together, these results imply that the SDF-1alpha-CXCR4 axis may play a role in the recruitment of CXCR4-positive DPCs toward the damaged sites...
  50. ncbi Modulation of dental inflammation by the sympathetic nervous system
    S R Haug
    Department of Biomedicine, Section for Physiology, Faculty of Medicine, University of Bergen, Jonas Lies vei 91, N 5009, Bergen, Norway
    J Dent Res 85:488-95. 2006
    ..In conclusion, this article presents evidence in support of interactions between the sympathetic nervous system and dental inflammation...
  51. ncbi Human pulpal response to mineral trioxide aggregate (MTA): a histologic study
    Varghese Chacko
    Department of Pedodontics and Preventive Dentistry, Government Dental College
    J Clin Pediatr Dent 30:203-9. 2006
    ..The pulpal inflammation was also less in the MTA group as compared to the calcium hydroxide group at the end of 4 and 8 weeks...
  52. ncbi Immunocytochemical investigation of immune cells within human primary and permanent tooth pulp
    H D Rodd
    Department of Oral Health and Development, School of Clinical Dentistry, University of Sheffield, Claremont Crescent, Sheffield S10 2TA, UK
    Int J Paediatr Dent 16:2-9. 2006
    ..The aim of this study was to determine whether there are any differences in the number and distribution of immune cells within human primary and permanent tooth pulp, both in health and disease...
  53. ncbi Regenerative potential of dental pulp
    Martin Trope
    J Endod 34:S13-7. 2008
    ..This article explores our knowledge in this regard and the future potential of saving or even regenerating the pulp as a routine dental procedure...
  54. doi Pulpal responses to bacterial contamination following dentin bridging beneath hard-setting calcium hydroxide and self-etching adhesive resin system
    Yuichi Kitasako
    Cariology and Operative Dentistry, Department of Restorative Sciences, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Dent Traumatol 24:201-6. 2008
    ..05). Bonding agent is supposed to seal the exposure site, and the remaining bonding agent on the cavities was effective as the barrier in the dentin bridges after bacterial challenges...
  55. ncbi Use of the cold test as a measure of pulpal anesthesia during endodontic therapy: a randomized, blinded, placebo-controlled clinical trial
    Grace W Hsiao-Wu
    Division of Endodontics, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, USA
    J Endod 33:406-10. 2007
    ..20 (p = .01). Subjects who achieved a negative response to the cold test were approximately 80% less likely to experience pain during RCT compared to subjects with soft tissue signs of anesthesia alone...
  56. ncbi A clinical classification of the status of the pulp and the root canal system
    P V Abbott
    School of Dentistry, The University of Western Australia, Nedlands
    Aust Dent J 52:S17-31. 2007
    ..With a comprehensive knowledge of the pathophysiology of pain and inflammation in the pulp tissues, clinicians may accomplish this task with confidence...
  57. ncbi Comparison of human pulp response to total-etch and self-etch bonding agents
    Seema Nayyar
    Department of Operative Dentistry and Endodontics, Government Dental College, PGIMS, Rohtak, Haryana, India
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104:e45-52. 2007
    ....
  58. ncbi Histologic evaluation of pulpotomy performed with ethyl-cyanoacrylate and calcium hydroxide
    Diana Santana de Albuquerque
    Department of Endodontics, School of Dentistry, Univesity of Pernambuco
    Braz Oral Res 20:226-30. 2006
    ....
  59. ncbi Pulpal response to a newly developed MMA based resin cement for bonding tooth-colored indirect restorations
    Yuichi Seki
    Cariology and Operative Dentistry, Department of Restorative Sciences, Graduate School, Tokyo Medical and Dental University, Japan
    Am J Dent 19:297-302. 2006
    ....
  60. ncbi Equivalency study of histological responses to complete or partial pulpotomies in inflamed baboon immature first permanent molars
    P Cleaton-Jones
    University of the Witwatersrand, Dental Research Institute, Johannesburg, South Africa
    SADJ 62:062-5. 2007
    ..Clinical studies in humans suggest that this may also be an acceptable technique for carious exposed pulps in molar teeth, but objective histological evidence to support this perception is lacking...
  61. ncbi Update on the adaptive immune responses of the dental pulp
    Chin Lo Hahn
    Department of Endodontics, School of Dentistry, Virginia Commonwealth University, 520 North 12th Street, Richmond, Virginia 23298 0566, USA
    J Endod 33:773-81. 2007
    ..The immunopathology of abscess formation and the mechanisms for painless pulpitis are also discussed.
  62. ncbi Histological, ultrastructural and quantitative investigations on the response of healthy human pulps to experimental capping with mineral trioxide aggregate: a randomized controlled trial
    P N R Nair
    Institute of Oral Biology, Section of Oral Structures and Development, Centre of Dental and Oral Medicine, University of Zurich, Zurich, Switzerland
    Int Endod J 41:128-50. 2008
    ..To investigate the pulpal response to direct pulp capping in healthy human teeth with mineral trioxide aggregate (MTA) as against calcium hydroxide cement (Dycal) as control...
  63. ncbi Histologic evaluation of direct pulp capping with a self-etching adhesive and calcium hydroxide in beagles
    Yu Lu
    Endodontic Department, West China College of Stomatology, Sichuan University, Chengdu, Sichuan, China
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:e78-84. 2006
    ..To evaluate the pulpal response of beagles following direct pulp capping with Clearfil SE Bond (SB), a self-etching adhesive...
  64. ncbi Response of human pulps capped with different self-etch adhesive systems
    M L R Accorinte
    Department of Dental Material, School of Dentistry, University of Brás Cubas, Sao Paulo, SP, Brazil
    Clin Oral Investig 12:119-27. 2008
    ..Calcium hydroxide should be used as the material of choice for pulp capping, and the use of two-step self-etch adhesives for human pulp capping is contraindicated...
  65. doi Clinical management and subsequent healing of teeth with horizontal root fractures
    Marco Aurélio Versiani
    Department of Endodontics, Brazilian Association of Dentistry, Uberlandia, Minas Gerais, Brazil
    Dent Traumatol 24:136-9. 2008
    ..In case 1, the pulp tissue was vital and no treatment was necessary. In case 2, a root canal treatment of the cervical fragment was necessary and in case 3, pulpal necrosis was verified and an apical surgery was performed...
  66. ncbi Electronic root canal length measurement before and after experimentally induced pulpitis and apical periodontitis in dogs
    Maja Kovacevic
    Department of Dental Pathology, Medical Faculty, Brace Branchetta 20, Rijeka, 51000, Croatia
    Med Biol Eng Comput 44:695-701. 2006
    ..b>Pulpitis and apical periodontitis were induced by pulp exposure and contamination by the oral flora in the premolar teeth ..
  67. ncbi The incidence of pulp healing defects with direct capping materials
    Peter E Murray
    Department of Endodontics, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, FL 33328, USA
    Am J Dent 19:171-7. 2006
    ....
  68. doi Immunohistochemical localization of LIM mineralization protein 1 in pulp-dentin complex of human teeth with normal and pathologic conditions
    Xiaoying Wang
    Key Laboratory of Oral Biomedical Engineering of Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China
    J Endod 34:143-7. 2008
    ..by immunohistochemistry in all of the samples including 12 healthy teeth, 10 teeth with caries, 12 teeth with pulpitis, and 4 teeth with pulp calcification...
  69. ncbi Recent advances and future directives in pulp biology
    Jianing He
    Department of Endodontics, Baylor College of Dentistry, Dallas, TX, USA
    Pract Proced Aesthet Dent 18:49-50, 52. 2006
  70. ncbi Histopathologic study on pulp response to single-bottle and self-etching adhesive systems
    Vicente O Medina
    Department of Clinical Dental Health Sciences, College of Dentistry, University of the Philippines Manila
    Oper Dent 27:330-42. 2002
    ..However, calcium hydroxide capping resulted in a higher incidence and faster rate of reparative dentin formation...
  71. ncbi Pulpal response to different pulp capping methods after pulp exposure by air abrasion
    Lina Maria Cardenas-Duque
    Department of Pediatric Dentistry, Nagasaki University, School of Dentistry, Japan
    J Clin Pediatr Dent 26:269-73. 2002
    ..However, the formation is delayed especially when Liner Bond II is used as capping agent...
  72. ncbi Saving pulps--a biological basis. An overview
    Peter E Murray
    School of Dentistry, University of Birmingham, UK
    Prim Dent Care 9:21-6. 2002
    ..The purpose of this paper is to determine the importance of cavity preparation and restoration variables, by ranking them according to their effect on pulp injury (odontoblast survival) and pulp repair (reactionary dentine secretion)...
  73. ncbi Influence of age on the behavior of dental pulp of dog teeth after capping with an adhesive system or calcium hydroxide
    Sandra R Mestrener
    Department of Operative Dentistry, School of Dentistry, the São Paulo State University, UNESP, Sao Paulo, Brazil
    Dent Traumatol 19:255-61. 2003
    ..In conclusion, the chronological age of the pulp influenced the comparative results only for the adhesive system (P = 0.1), and the total results were better with calcium hydroxide than with the All Bond 2 system (P = 0.01)...
  74. ncbi Direct capping of human pulps with a dentin bonding system or with calcium hydroxide cement
    Preben Hörsted-Bindslev
    Department of Dental Pathology, Operative Dentistry and Endodontics, Royal Dental College, Faculty of Health Sciences, University of Aarhus, Denmark
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96:591-600. 2003
    ..To study human pulp reactions to direct cappings with a dentin adhesive compared with a calcium hydroxide cement, especially with respect to formation of hard tissue in the exposure site...
  75. ncbi Local application of IGF1 on dental pulp mechanically exposed; in vivo study on rabbit
    M Haddad
    Department of Oral Pathology, St Joseph University, Faculty of Dental Medicine, Beirut, Lebanon
    Bull Group Int Rech Sci Stomatol Odontol 45:12-7. 2003
    ..The results were conclusive in indicating the IGF1 as an efficient dental pulp capping product...
  76. ncbi Prostaglandin E2 and treatment outcome in pulp therapy of primary molars with carious exposures
    P J Waterhouse
    The Department of Child Dental Health, The Dental School, University of Newcastle upon Tyne, UK
    Int J Paediatr Dent 12:116-23. 2002
    Prostaglandin E2 (PGE2) has been suggested as an indicator of irreversible pulpitis in permanent teeth [1]. There is scant information on the role of chemical mediators in primary molar pulp inflammation...
  77. ncbi Histological and scanning electron microscopy assessment of various vital pulp-therapy materials
    Mercedes S Dominguez
    Department of Restorative Sciences, Graduate Endodontics, Baylor College of Dentistry, Dallas TX 75246, USA
    J Endod 29:324-33. 2003
    ..357) or 150 days (p = 0.198). Moreover, histologically mineral trioxide aggregate was a considerably better material than calcium hydroxide or acid-etched dentin bonding in maintaining the integrity of the pulp...
  78. ncbi Comparison of pulp responses to resin composites
    P E Murray
    College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, FL, USA
    Oper Dent 28:242-50. 2003
    ..These observations suggest that adhesive systems provide acceptable biocompatibility, however, there is strong potential for improvement...
  79. ncbi Preserving the vital pulp in operative dentistry: 2. Guidelines for successful restoration of unexposed dentinal lesions
    Peter E Murray
    School of Dentistry, University of Birmingham
    Dent Update 29:127-34. 2002
    ..Odontoblast survival, pulp inflammation, and tertiary dentine area are used as measures of pulp injury and repair...
  80. ncbi Pulpal responses to caries and dental repair
    A J Smith
    Oral Biology School of Dentistry, University of Birmingham, UK
    Caries Res 36:223-32. 2002
    ..This review examines the interplay between these events and the opportunities for tissue regeneration following caries...
  81. ncbi Analysis of pulpal reactions to restorative procedures, materials, pulp capping, and future therapies
    Peter E Murray
    Department of Oral Biology, Indiana University School of Dentistry, 1121 West Michigan Street, Indianapolis, IN 46202 5186, USA
    Crit Rev Oral Biol Med 13:509-20. 2002
    ..However, until these therapies can be introduced clinically, the avoidance of post-operative complications with conventional therapies requires attention to numerous aspects of treatment highlighted in this review...
  82. ncbi Matrix metalloproteinase-8 (MMP-8) in pulpal and periapical inflammation and periapical root-canal exudates
    J Wahlgren
    Faculty of Medicine and Biomedicum, Oral Pathology Unit Laboratory Diagnostics, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    Int Endod J 35:897-904. 2002
    ..To study the presence, levels and molecular forms of matrix metalloproteinase (MMP) -8 (collage-nase-2) in pulpal and periapical inflammation, and the changes in MMP-8 levels in root-canal exudates during root-canal treatment...
  83. ncbi Comparison of pulp responses following restoration of exposed and non-exposed cavities
    P E Murray
    Oral Biology, Indiana University School of Dentistry, Room 271, 1121 West Michigan Street, Indianapolis, IN 46202 5186, USA
    J Dent 30:213-22. 2002
    ....
  84. ncbi The mechanism of pulpal wound healing
    Leo Tjäderhane
    Department of Endodontics, Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ontario, M5G 1G6, Canada
    Aust Endod J 28:68-74. 2002
    ..In this review, some of the aspects considered to be important in pulpal wound healing are discussed...
  85. ncbi Pulpal response to a fluoride-releasing all-in-one resin bonding system
    Hidekazu Sonoda
    Tokyo Medical and Dental University, Graduate School, Department of Restorative Sciences, Cariology and Operative Dentistry, Japan
    Oper Dent 27:271-7. 2002
    ..The pulpal response of the Reactmer group was minimally different from that of the control group. Consequently, the Reactmer system was determined as being biologically compatible with vital pulps...
  86. ncbi Histomorphometric analysis of dentinal bridge formation and pulpal inflammation
    Yuichi Kitasako
    Department of Restorative Sciences, Graduate School, Tokyo Medical and Dental University, Japan
    Quintessence Int 33:600-8. 2002
    ..The importance and effects of individual pulp capping variables are not well understood; consequently histomorphometric analysis was used to analyze these variables...
  87. ncbi Effect of methotrexate-induced neutropenia on pulpal inflammation in rats
    Koki Nakamura
    Department of Endodontics, School of Dentistry, Aichi Gakuin University, Nagoya, Japan
    J Endod 28:287-90. 2002
    ..Immunohistochemically, the neutropenia resulted in inhibition of the infiltration by neutrophils. These results suggest that the neutrophil plays an important role in the defense against bacteria in pulpal tissue...
  88. ncbi Mental nerve paresthesia associated with an adhesive resin restoration: a case report
    Osvaldo Zmener
    Department of Adult Dental Care Section of Endodontics, Faculty of Odontology, University of Buenos Aires, Argentina
    J Endod 30:117-9. 2004
    ..The restoration was removed, and the paresthesia had completely resolved after nonsurgical endodontic therapy. Epicutaneous patch testing response indicated a possible causal relationship between the filling material and paresthesia...
  89. ncbi Pulp-dentin biology in restorative dentistry. Part 7: The exposed pulp
    Ivar A Mjor
    Department of Operative Dentistry, University of Florida, College of Dentistry, PO Box 100415, Gainesville, Florida 32610, USA
    Quintessence Int 33:113-35. 2002
    ..If an exposure is expected through a caries lesion, stepwise excavation of the carious dentin should be considered to allow healing of the dentin and pulp prior to the final excavation of the carious dentin...
  90. ncbi Pulp-dentin biology in restorative dentistry. Part 4: Dental caries--characteristics of lesions and pulpal reactions
    L Bjørndal
    Department of Cariology and Endodontics, School of Dentistry, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Quintessence Int 32:717-36. 2001
    ..Optimal assessment of the prevailing clinical conditions can only be made on the basis of thorough knowledge of the biology of the pulp-dentin organ...
  91. ncbi Quantitation of catecholamines in inflamed human dental pulp by high-performance liquid chromatography
    C Nup
    Department of Endodontics, New York University College of Dentistry, New York 10010, USA
    J Endod 27:73-5. 2001
    ..Catecholamine levels found to be present in the pulp during inflammation were greater than the baseline level established in uninflamed pulp tissue...
  92. ncbi Response of human pulps following acid conditioning and application of a bonding agent in deep cavities
    Carlos Alberto de Souza Costa
    Department of Physiology and Pathology, University of Sao Paulo State Unesp, Araraquara School of Dentistry, Rua Humaita 1680, CEP 14801 903, Araraquara, Sao Paulo, Brazil
    Dent Mater 18:543-51. 2002
    ..The aim of this in vivo study was to evaluate the human dental pulp response when a one-bottle adhesive system was applied on etched or unetched deep dentine...
  93. ncbi Adverse effects of human pulps after direct pulp capping with the different components from a total-etch, three-step adhesive system
    Maria de Lourdes Rodrigues Accorinte
    Department of Dental Materials, School of Dentistry, University of Sao Paulo, SP, Brazil
    Dent Mater 21:599-607. 2005
    ..The objective was to evaluate the response of human pulps capped with different components from a total-etch three-step adhesive system...
  94. ncbi Response of human pulp capped with a bonding agent after bleeding control with hemostatic agents
    Maria de Lourdes Rodrigues Accorinte
    Department of Dental Materials, School of Dentistry, University of Sao Paulo, Sao Paulo, SP, Brazil
    Oper Dent 30:147-55. 2005
    ..This study evaluated the response of human pulps capped with a bonding agent after bleeding control with different hemostatic agents...
  95. ncbi Pulp tissue reactions to a dentin bonding agent as a direct capping agent
    Rustem Kemal Subay
    Department of Endodontics, School of Dentistry, Istanbul University, Istanbul, Turkey
    J Endod 31:201-4. 2005
    ..Direct capping with Dycal with subsequent sealing with SMPP may show favorable results in pulp tissue. SMPP may cause inflammatory changes when applied directly to exposed pulp tissue...
  96. ncbi Pulpal responses following direct pulp capping of healthy dog teeth with dentine adhesive systems
    E Koliniotou-Koumpia
    Department of Operative Dentistry, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
    J Dent 33:639-47. 2005
    ..The aim of the present study was to evaluate the pulpal responses following direct pulp capping of mechanically exposed teeth with new dentine adhesive systems, in the preclinical model of dog teeth...
  97. ncbi Which mechanical and physical testing methods are relevant for predicting the clinical performance of ceramic-based dental prostheses?
    K J Anusavice
    College of Dentistry, University of Florida, Gainesville, FL, USA
    Clin Oral Implants Res 18:218-31. 2007
    ..These conditions include secondary caries, irreversible pulpitis, excessive wear of opposing tooth surfaces, excessive erosion and roughening of the ceramic surface, ditching of ..
  98. ncbi Monoamine oxidase and semicarbazide sensitive amine oxidase activities in normal and inflamed human dental pulp
    Tatyana Vavilova
    Moscow Medical Dental University, Moscow, Russia
    Med Sci Monit 15:BR289-292. 2009
    ..In other tissues SSAO is involved in oxidative stress and inflammation, but the role of MAO and SSAO in human pulp and changes of their activities in reversible pulpitis still remains poorly understood.
  99. ncbi Defence reaction in dental pulp after pulp capping and partial pulpectomy in dogs
    Z Pavlica
    Small Animal Clinic, Forensic and Administrative Veterinary Medicine, Veterinary Faculty, Univesity of Ljubljana, Gerbiceva 60, 1000 Ljubljana, Slovenia
    Acta Vet Hung 48:23-34. 2000
    ..Histological sections were prepared and examined for degree and type of pulp inflammation (hyperaemia, pulpitis, necrosis or gangrene)...
  100. ncbi Postoperative complaints following impacted mandibular third molar surgery in Ile-Ife, Nigeria
    F O Oginni
    Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Obafemi Awolowo University, Ile Ife, Osun State, Nigeria
    SADJ 57:264-8. 2002
    ..One hundred and twenty seven records were retrieved. Pericoronitis (71.2%), pulpitis (17.6%) and periodontitis (11.2%) were the reasons for surgery...
  101. ncbi Lipopolysaccharide stimulates histamine-forming enzyme (histidine decarboxylase) activity in murine dental pulp and gingiva
    Noriaki Shoji
    Department of Oral Diagnosis, Graduate School of Dentistry, Tohoku University, Seiryo machi, Aoba ku Sendai 980 8575, Japan
    Arch Oral Biol 51:856-60. 2006
    ..produced in oral tissues in response to bacterial agents such as LPS could be involved in development of pulpitis or gingivitis (periodontitis), the most common diseases in the dental clinic, and that efforts to inhibit HDC ..

Research Grants72

  1. FACIAL BEHAVIOR RELATED TO ACUTE DENTAL PAIN
    Linda LeResche; Fiscal Year: 1990
    ..of pain and emotion in these TMD patients with those of a) normal, pain-free controls, b) patients with acute pulpitis pain, and c) patients with initial episode and recurrent depression. 3...
  2. BioPulp: Bioengineeering approaches for dental pulp regeneration
    SUSAN FU; Fiscal Year: 2009
    ..When caries or trauma involves dental pulp, endodontic therapies are indicated. In irreversible pulpitis, the dentist or endodontist extirpates dental pulp, and obturates the instrumented root canal with bioinert ..
  3. DISTRIBUTION AND ULTRASTRUCTURE OF DENTAL INNERVATION
    MARGARET BYERS; Fiscal Year: 1993
    ..three types of injury to rat molars will be done: shallow cavities; small pulp exposures causing limited pulpitis; and large occlusal exposures causing irreversible pulpitis...
  4. DISTRIBUTION AND ULTRASTRUCTURE OF DENTAL INNERVATION
    MARGARET BYERS; Fiscal Year: 1992
    ..three types of injury to rat molars will be done: shallow cavities; small pulp exposures causing limited pulpitis; and large occlusal exposures causing irreversible pulpitis...
  5. DISTRIBUTION AND ULTRASTRUCTURE OF DENTAL INNERVATION
    MARGARET BYERS; Fiscal Year: 1991
    ..three types of injury to rat molars will be done: shallow cavities; small pulp exposures causing limited pulpitis; and large occlusal exposures causing irreversible pulpitis...
  6. DISTRIBUTION AND ULTRASTRUCTURE OF DENTAL INNERVATION
    MARGARET BYERS; Fiscal Year: 1990
    ..three types of injury to rat molars will be done: shallow cavities; small pulp exposures causing limited pulpitis; and large occlusal exposures causing irreversible pulpitis...
  7. Sodium Channel Expression in Human Teeth
    Michael Henry; Fiscal Year: 2005
    ..Normal wisdom teeth and diseased teeth with a diagnosis of irreversible pulpitis and known pain levels are commonly extracted, providing an ample supply of tissues for analysis...
  8. Sodium Channel Expression in Human Teeth
    Michael Henry; Fiscal Year: 2006
    ..Normal wisdom teeth and diseased teeth with a diagnosis of irreversible pulpitis and known pain levels are commonly extracted, providing an ample supply of tissues for analysis...
  9. Sodium Channel Expression in Human Teeth
    Michael Henry; Fiscal Year: 2007
    ..Normal wisdom teeth and diseased teeth with a diagnosis of irreversible pulpitis and known pain levels are commonly extracted, providing an ample supply of tissues for analysis...
  10. Sodium Channel Expression in Human Teeth
    Michael Henry; Fiscal Year: 2009
    ..Normal wisdom teeth and diseased teeth with a diagnosis of irreversible pulpitis and known pain levels are commonly extracted, providing an ample supply of tissues for analysis...
  11. Sodium Channel Expression in Human Teeth
    Michael Henry; Fiscal Year: 2005
    ..Normal wisdom teeth and diseased teeth with a diagnosis of irreversible pulpitis and known pain levels are commonly extracted, providing an ample supply of tissues for analysis...
  12. Dental Biologics for Underserved Populations
    SUSAN FU; Fiscal Year: 2010
    ..When caries or trauma involves dental pulp, endodontic therapies are indicated. In irreversible pulpitis, the dentist or endodontist extirpates dental pulp, and obturates the instrumented root canal with bioinert ..
  13. Dental Biologics for Underserved Populations
    SUSAN FU; Fiscal Year: 2009
    ..When caries or trauma involves dental pulp, endodontic therapies are indicated. In irreversible pulpitis, the dentist or endodontist extirpates dental pulp, and obturates the instrumented root canal with bioinert ..
  14. Mechanisms and Treatment of Dental Pain
    Michael Gold; Fiscal Year: 2009
    ..have been proposed, none are able to account for the nature and extent of LA failure observed in the presence of pulpitis. In the present application, we propose to test a novel hypothesis concerning the basis of LA failure in the ..
  15. Mechanisms and Treatment of Dental Pain
    Michael Gold; Fiscal Year: 2009
    ..have been proposed, none are able to account for the nature and extent of LA failure observed in the presence of pulpitis. In the present application, we propose to test a novel hypothesis concerning the basis of LA failure in the ..
  16. Mechanisms and Treatment of Dental Pain
    Michael S Gold; Fiscal Year: 2010
    ..have been proposed, none are able to account for the nature and extent of LA failure observed in the presence of pulpitis. In the present application, we propose to test a novel hypothesis concerning the basis of LA failure in the ..
  17. DISTRIBUTION OF LYMPHATICS IN THE DENTAL PULP
    Mark Bishop; Fiscal Year: 1990
    ..In addition it may provide insight into the remarkably variable symptoms and progress of pulpitis. Looking further ahead the retrograde perfusion method could be applied to scanning and transmission electron ..
  18. Prevention and Treatment of Oral Biofilms and Related Oral Disease by Soluble Chi
    SHENDA BAKER; Fiscal Year: 2009
    ..to prevent and treat dental disease encompassing broad treatment applications including caries, periodontitis and pulpitis. Our novel agents interfere with microbial colonization and growth and are the basis of this proposal...
  19. Biomimetics for Dentin Regeneration
    R Rutherford; Fiscal Year: 2003
    ..These experiments will employ our published model of reversible pulpitis induced in adult ferret teeth...
  20. Role of TRP channels in pulpitis-induced thermal hyperalgesia
    Man Kyo Chung; Fiscal Year: 2010
    ..The objective of the research project is to investigate the role of TRP channels in pulpitis-induced thermal hyperalgesia...
  21. Role of TRP channels in pulpitis-induced thermal hyperalgesia
    Man Kyo Chung; Fiscal Year: 2009
    ..The objective of the research project is to investigate the role of TRP channels in pulpitis-induced thermal hyperalgesia...
  22. Molecular Regulation of Human Dental Stem Cell Property
    Cun Yu Wang; Fiscal Year: 2005
    ..stem cells offer an attractive regenerative therapy for dental and periodontal defects caused by dental decay/pulpitis and periodontitis...
  23. Molecular Regulation of Human Dental Stem Cell Property
    Cun Yu Wang; Fiscal Year: 2006
    ..stem cells offer an attractive regenerative therapy for dental and periodontal defects caused by dental decay/pulpitis and periodontitis...
  24. Individual Differences in Pain Modulation as Predictors of Post-Surgical Pain
    Robert Edwards; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  25. Cytokine Regulation of Periradicular Pain in Humans
    Asma Khan; Fiscal Year: 2007
    ..Dr Kenneth Kornman of IL Genetics will serve as a consultant on this project and will oversee the genotyping and genetic analysis. Statistical consultation will be provided by Dr. Brad Pollock. ..
  26. Ceramic Prosthesis Survival Based on Cares/Life Analysis
    Kenneth Anusavice; Fiscal Year: 2007
    ..This study should yield clinically-relevant fatigue data and an improved method for assessing the time-dependent survival probability of ceramic prostheses. ..
  27. Xylitol Adult Caries Trial (X-ACT)--Study Chair application
    James Bader; Fiscal Year: 2008
    ..Little research has been done on methods to prevent tooth decay in adults. This study would test how well a lozenge to be taken several times a day works to prevent tooth decay in adults who are prone to tooth decay. ..
  28. Xylitol Adult Caries Trial (X-ACT)--Study Chair application
    James Bader; Fiscal Year: 2007
    ..Little research has been done on methods to prevent tooth decay in adults. This study would test how well a lozenge to be taken several times a day works to prevent tooth decay in adults who are prone to tooth decay. ..
  29. Community Oral Health Interventions Program
    Amid Ismail; Fiscal Year: 2008
    ..COHIP is collaborating with FQHC operational experts and has the support of HRSA regional office, University of Michigan ($1 Million grant), and the NNHOA. ..
  30. RESIN-BASED REMINERALIZING CEMENTS AND COMPOSITES
    SABINE DICKENS; Fiscal Year: 2009
    ..Completion of this research will lead to Ca- PO4 cements and composites with improved adhesion to dentin and improved strength for ART and the treatment of root caries. ..
  31. Translational Basic-Clinical Analysis of Implant-Borne Ceramic Bridge Survival
    KENNETH JOHN ANUSAVICE; Fiscal Year: 2010
    ..The comparative evaluation of results from the two studies will provide critically important validation of a cost-effective in vitro model for systematically evaluating new ceramic materials. ..
  32. Ceramic Prosthesis Survival Based on Cares/Life Analysis
    Kenneth Anusavice; Fiscal Year: 2008
    ..This study should yield clinically-relevant fatigue data and an improved method for assessing the time-dependent survival probability of ceramic prostheses. ..
  33. OPTIMIZATION OF RESTORATION DESIGN
    Kenneth Anusavice; Fiscal Year: 1992
    ..The results of these studies should serve as the basis for optimizing the design and thermal processing conditions which can enhance the long-term performance of ceramic-based restorations...
  34. Osteopontin and Molecular Mechanisms of Bone Metastasis
    Susan Rittling; Fiscal Year: 2005
    ..Together, these experiments will provide important data to establish the mechanism of bone metastasis by a novel cell line and define the role of host OPN and TGF-beta as potential therapeutic targets. ..
  35. Osteopontin and Molecular Mechanisms of Bone Metastasis
    Susan Rittling; Fiscal Year: 2004
    ..Together, these experiments will provide important data to establish the mechanism of bone metastasis by a novel cell line and define the role of host OPN and TGF-beta as potential therapeutic targets. ..
  36. Michigan Oral Cancer Prevention Network
    Amid Ismail; Fiscal Year: 2003
    ..By the end of the 3rd year, or earlier, the MOPCN would be ready to plan and implement community-based intervention studies...
  37. Oral Streptococci, Cytokines, PAF-r in EC Coagulation
    Chin Lo Hahn; Fiscal Year: 2003
    ..We also hope to provide an insight regarding streptococcal invasion into EC and offer an alternative model for the initial formation of vegetation. ..
  38. ORAL HEALTH OF OLDER TYPE 1 DIABETIC PATIENTS
    Paul Moore; Fiscal Year: 2003
    ..This overall plan will permit us to understand the etiology of these complications and to define specific subpopulations and risk factors appropriate for future prospective oral health prevention and intervention trials. ..
  39. Microbiology/Immunology of Periodontal Disease in T1DM
    Paul Moore; Fiscal Year: 2002
    ..An integrated multidisciplinary effort provides significant data collection capabilities essential for understanding the complex multifactorial etiology of periodontal disease in Type 1 diabetes. ..
  40. CONTROLLED-RELEASE SEALANT TO PREVENT SECONDARY CARIES
    Kenneth Anusavice; Fiscal Year: 2002
    ..mutans, site specific levels of S. mutans at the margins of amalgam and composite restorations, and the width of marginal crevices adjacent to amalgam and composite restorations). ..
  41. Planning Grant for Xylitol Trial in Caries-Active Adults
    James Bader; Fiscal Year: 2005
    ....
  42. International Caries Detection and Assessement System
    Amid Ismail; Fiscal Year: 2005
    ..Finding of the workshop will be used in a second workshop, to be organized by Dr. George Stookey, which will focus on the design of caries clinical trials and new diagnostic technology. ..
  43. OPTIMIZATION OF RESTORATION DESIGN
    Kenneth Anusavice; Fiscal Year: 1993
    ..The results of these studies should serve as the basis for optimizing the design and thermal processing conditions which can enhance the long-term performance of ceramic-based restorations...
  44. Ceramic Prosthesis Survival Based on Cares/Life Analysis
    Kenneth Anusavice; Fiscal Year: 2006
    ..This study should yield clinically-relevant fatigue data and an improved method for assessing the time-dependent survival probability of ceramic prostheses. ..
  45. REMINERALIZING PULP-CAPPING CEMENTS & BONDING AGENTS
    SABINE DICKENS; Fiscal Year: 2002
    ..The proposed studies will also provide a valuable comparison of in vivo test results to pulp cell response in vitro. ..
  46. ORAL HEALTH OF OLDER TYPE 1 DIABETIC PATIENTS
    Paul Moore; Fiscal Year: 2002
    ..This overall plan will permit us to understand the etiology of these complications and to define specific subpopulations and risk factors appropriate for future prospective oral health prevention and intervention trials. ..
  47. IMPROVED PREVENTIVE/RESTORATIVE RESINS AND COMPOSITES
    SABINE DICKENS; Fiscal Year: 2006
    ..The data gathered in these experiments will serve to support a larger R01 grant application with the long-term objectives of developing improved durable materials for adhesives and adhesive composites. [unreadable] [unreadable]..
  48. RESIN-BASED REMINERALIZING CEMENTS AND COMPOSITES
    SABINE DICKENS; Fiscal Year: 2006
    ..Completion of this research will lead to Ca- PO4 cements and composites with improved adhesion to dentin and improved strength for ART and the treatment of root caries. ..
  49. ORAL HEALTH OF OLDER TYPE 1 DIABETIC PATIENTS
    Paul Moore; Fiscal Year: 2001
    ..This overall plan will permit us to understand the etiology of these complications and to define specific subpopulations and risk factors appropriate for future prospective oral health prevention and intervention trials. ..
  50. Osteopontin and Molecular Mechanisms of Bone Metastasis
    Susan Rittling; Fiscal Year: 2003
    ..Together, these experiments will provide important data to establish the mechanism of bone metastasis by a novel cell line and define the role of host OPN and TGF-beta as potential therapeutic targets. ..
  51. REMINERALIZING PULP-CAPPING CEMENTS & BONDING AGENTS
    SABINE DICKENS; Fiscal Year: 2003
    ..The proposed studies will also provide a valuable comparison of in vivo test results to pulp cell response in vitro. ..
  52. Research Program and Administrative Center
    Amid Ismail; Fiscal Year: 2008
    ..The COHIP team brings a wealth of expertise and knowledge to develop and implement programs to significantly reduce or eliminate the burden of oral health inequalities. ..
  53. Osteopontin and Molecular Mechanisms of Bone Metastasis
    Susan Rittling; Fiscal Year: 2006
    ..Together, these experiments will provide important data to establish the mechanism of bone metastasis by a novel cell line and define the role of host OPN and TGF-beta as potential therapeutic targets. ..
  54. RESIN-BASED REMINERALIZING CEMENTS AND COMPOSITES
    SABINE DICKENS; Fiscal Year: 2005
    ..Completion of this research will lead to Ca- PO4 cements and composites with improved adhesion to dentin and improved strength for ART and the treatment of root caries. ..
  55. Catastrophizing and Pain in Rheumatoid Arthritis
    Robert Edwards; Fiscal Year: 2008
    ..abstract_text> ..
  56. RESIN-BASED REMINERALIZING CEMENTS AND COMPOSITES
    SABINE DICKENS; Fiscal Year: 2008
    ..Completion of this research will lead to Ca- PO4 cements and composites with improved adhesion to dentin and improved strength for ART and the treatment of root caries. ..
  57. Catastrophizing and Pain in Rheumatoid Arthritis
    Robert Edwards; Fiscal Year: 2007
    ..abstract_text> ..
  58. RESIN-BASED REMINERALIZING CEMENTS AND COMPOSITES
    SABINE DICKENS; Fiscal Year: 2007
    ..Completion of this research will lead to Ca- PO4 cements and composites with improved adhesion to dentin and improved strength for ART and the treatment of root caries. ..
  59. Individual Differences in Pain Modulation as Predictors of Post-Surgical Pain
    Robert Edwards; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  60. REMINERALIZING PULP-CAPPING CEMENTS & BONDING AGENTS
    SABINE DICKENS; Fiscal Year: 2001
    ..The proposed studies will also provide a valuable comparison of in vivo test results to pulp cell response in vitro. ..