cleft lip

Summary

Summary: Congenital defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences. It is thought to be caused by faulty migration of the mesoderm in the head region.

Top Publications

  1. ncbi Epidemiological studies on the frequency of clefts in Europe and world-wide
    Karsten K H Gundlach
    Rostock Interdisciplinary Center for Clefts of Lip, Alveolus and Palate and Craniofacial Anomalies, Rostock, University, Germany
    J Craniomaxillofac Surg 34:1-2. 2006
  2. ncbi Unraveling human cleft lip and palate research
    A R Vieira
    Departments of Oral Biology and Pediatric Dentistry, School of Dental Medicine, University of Pittsburgh, PA 15261, USA
    J Dent Res 87:119-25. 2008
  3. ncbi The prevalence of caries in children with a cleft lip and/or palate in Southern Vietnam
    Sjobbe Besseling
    Department of Oral and Maxillofacial Surgery, Vrije Universiteit, Amsterdam, The Netherlands
    Cleft Palate Craniofac J 41:629-32. 2004
  4. ncbi PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase
    Christoph Loenarz
    Oxford Centre for Integrative Systems Biology, University of Oxford, Oxford, UK
    Hum Mol Genet 19:217-22. 2010
  5. ncbi Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate
    Elisabeth Mangold
    Institute of Human Genetics, Life and Brain Center, University of Bonn, Bonn, Germany
    Nat Genet 42:24-6. 2010
  6. ncbi Expression analyses of human cleft palate tissue suggest a role for osteopontin and immune related factors in palatal development
    Linda P Jakobsen
    Wilhelm Johannsen Centre for Functional Genome Research, Department of Cellular and Molecular Medicine, Panum Institute, Copenhagen, Denmark
    Exp Mol Med 41:77-85. 2009
  7. ncbi A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4
    Terri H Beaty
    Johns Hopkins University, School of Public Health, Baltimore, Maryland, USA
    Nat Genet 42:525-9. 2010
  8. ncbi Risk factors for oral clefts: a population-based case-control study in Shenyang, China
    Wei Wang
    Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China
    Paediatr Perinat Epidemiol 23:310-20. 2009
  9. ncbi Secondary alveolar bone grafting: the dilemma of donor site selection and morbidity
    Ma amon A Rawashdeh
    Department Oral and Maxillofacial Surgery, Jordan University of Science and Technology, Jordan
    Br J Oral Maxillofac Surg 46:665-70. 2008
  10. ncbi Epidemiology of cleft lip and cleft palate in Pakistan
    Mohammed Mehboob Elahi
    Division of Plastic and Reconstructive Surgery, Temple University, 1600 Arch Street, Suite 508, Philadelphia, PA 19103, USA
    Plast Reconstr Surg 113:1548-55. 2004

Research Grants

  1. Quality of Life in Children with Cleft
    Hillary L Broder; Fiscal Year: 2010
  2. Quality of Life in Children with Cleft
    Hillary L Broder; Fiscal Year: 2010
  3. Quality of Life in Children with Cleft
    Hillary Broder; Fiscal Year: 2009
  4. INTERNATIONAL GENETIC EPIDEMIOLOGY OF ORAL CLEFTS
    Terri Beaty; Fiscal Year: 2009
  5. Effects of oral clefts on birth outcomes and cleft risks due to maternal smoking
    GEORGE WEHBY; Fiscal Year: 2007
  6. Health outcomes and improved phenotypic characterization of cleft lip and palate
    GEORGE WEHBY; Fiscal Year: 2007
  7. Health outcomes and improved phenotypic characterization of cleft lip and palate
    GEORGE WEHBY; Fiscal Year: 2009
  8. Effects of Dioxin on Vietnamese Civilians
    David Carpenter; Fiscal Year: 2004
  9. Speech Intelligibility Testing in Children with Repaired Cleft Palate
    David Zajac; Fiscal Year: 2007
  10. Eustachian Tube Form/Function in Cleft Lip and Palate
    Anil Gungor; Fiscal Year: 2004

Detail Information

Publications235 found, 100 shown here

  1. ncbi Epidemiological studies on the frequency of clefts in Europe and world-wide
    Karsten K H Gundlach
    Rostock Interdisciplinary Center for Clefts of Lip, Alveolus and Palate and Craniofacial Anomalies, Rostock, University, Germany
    J Craniomaxillofac Surg 34:1-2. 2006
    ..Most textbooks present data on the various frequencies of clefts in different human "races". This was studied in more detail...
  2. ncbi Unraveling human cleft lip and palate research
    A R Vieira
    Departments of Oral Biology and Pediatric Dentistry, School of Dental Medicine, University of Pittsburgh, PA 15261, USA
    J Dent Res 87:119-25. 2008
    The focus of this work is to highlight the most recent advances in the understanding of cleft lip and palate occurrence...
  3. ncbi The prevalence of caries in children with a cleft lip and/or palate in Southern Vietnam
    Sjobbe Besseling
    Department of Oral and Maxillofacial Surgery, Vrije Universiteit, Amsterdam, The Netherlands
    Cleft Palate Craniofac J 41:629-32. 2004
    ..The aim of this study was to investigate the prevalence of caries in South Vietnamese children with a known oral cleft...
  4. ncbi PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase
    Christoph Loenarz
    Oxford Centre for Integrative Systems Biology, University of Oxford, Oxford, UK
    Hum Mol Genet 19:217-22. 2010
    Mutations of human PHF8 cluster within its JmjC encoding exons and are linked to mental retardation (MR) and a cleft lip/palate phenotype...
  5. ncbi Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate
    Elisabeth Mangold
    Institute of Human Genetics, Life and Brain Center, University of Bonn, Bonn, Germany
    Nat Genet 42:24-6. 2010
    We conducted a genome-wide association study for nonsyndromic cleft lip with or without cleft palate (NSCL/P) in 401 affected individuals and 1,323 controls, with replication in an independent sample of 793 NSCL/P triads...
  6. ncbi Expression analyses of human cleft palate tissue suggest a role for osteopontin and immune related factors in palatal development
    Linda P Jakobsen
    Wilhelm Johannsen Centre for Functional Genome Research, Department of Cellular and Molecular Medicine, Panum Institute, Copenhagen, Denmark
    Exp Mol Med 41:77-85. 2009
    b>Cleft lip and/or palate (CL/P) is a common congenital malformation with a complex etiology which is not fully elucidated yet...
  7. ncbi A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4
    Terri H Beaty
    Johns Hopkins University, School of Public Health, Baltimore, Maryland, USA
    Nat Genet 42:525-9. 2010
    Case-parent trios were used in a genome-wide association study of cleft lip with and without cleft palate...
  8. ncbi Risk factors for oral clefts: a population-based case-control study in Shenyang, China
    Wei Wang
    Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China
    Paediatr Perinat Epidemiol 23:310-20. 2009
    ..76 per 1000. The ratio of cleft lip with or without cleft palate (CL +/- P) : cleft palate only (CP) was 5.60:1...
  9. ncbi Secondary alveolar bone grafting: the dilemma of donor site selection and morbidity
    Ma amon A Rawashdeh
    Department Oral and Maxillofacial Surgery, Jordan University of Science and Technology, Jordan
    Br J Oral Maxillofac Surg 46:665-70. 2008
    ..Much more research and development are necessary to find a suitable carrier for rhBMP-2, and to study the properties of newly formed bone that it has induced before it can be a substitute for autogenous bone...
  10. ncbi Epidemiology of cleft lip and cleft palate in Pakistan
    Mohammed Mehboob Elahi
    Division of Plastic and Reconstructive Surgery, Temple University, 1600 Arch Street, Suite 508, Philadelphia, PA 19103, USA
    Plast Reconstr Surg 113:1548-55. 2004
    ..serve as a means of establishing data important for the diagnosis, treatment, and counseling of patients with cleft lip and cleft palate...
  11. ncbi Mutations in BMP4 are associated with subepithelial, microform, and overt cleft lip
    Satoshi Suzuki
    Division of Research and Treatment for Oral and Maxillofacial Congenital Anomalies, School of Dentistry, Aichi Gakuin University, Chikusa ku, Nagoya, Japan
    Am J Hum Genet 84:406-11. 2009
    b>Cleft lip with or without cleft palate (CL/P) is a complex trait with evidence that the clinical spectrum includes both microform and subepithelial lip defects...
  12. ncbi Ozone and other air pollutants and the risk of oral clefts
    Bing Fang Hwang
    Department of Occupational Safety and Health, College of Public Health, China Medical University, Taichung, Taiwan
    Environ Health Perspect 116:1411-5. 2008
    ..Air pollution influences the development of oral clefts in animals. There are few epidemiologic data on the relation of prenatal air pollution exposure and the risk of oral clefts...
  13. ncbi FOXE1 association with both isolated cleft lip with or without cleft palate, and isolated cleft palate
    Lina M Moreno
    Department of Orthodontics, College of Dentistry, University of Iowa, Iowa City, IA 52242, USA
    Hum Mol Genet 18:4879-96. 2009
    ..A previous genome-wide linkage scan discovered a novel locus for cleft lip with or without cleft palate (CL/P) at 9q22-q33...
  14. ncbi Folate-related gene polymorphisms as risk factors for cleft lip and cleft palate
    James L Mills
    Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Birth Defects Res A Clin Mol Teratol 82:636-43. 2008
    b>Cleft lip with or without cleft palate (CLP) and cleft palate only (CPO) have an inherited component and, many studies suggest, a relationship with folate...
  15. ncbi Cleft lip and palate as a cost-effective health care treatment in the developing world
    William P Magee
    Operation Smile, 6435 Tidewater Drive, Norfolk, Virginia 23509, USA
    World J Surg 34:420-7. 2010
    ..The authors suggest that surgery has an important role in global public health, specifically through international volunteer surgical missions as a vehicle for delivery...
  16. ncbi Cleft lip and palate: the Jos experience
    K S Orkar
    Department of Surgery, Jos University Teaching Hospital, P.M.B. 2076, Jos, Nigeria
    East Afr Med J 79:510-3. 2002
    OBJECTIVE: To determine the pattern of occurrence of cleft lip/palate and the factors that may have influenced treatment outcome. DESIGN: Descriptive Study. SETTING: Jos University Teaching Hospital, Jos, Nigeria...
  17. ncbi Regional anesthesia for cleft lip repair: a preliminary study
    Naveen Eipe
    Department of Anesthesia, Padhar Hospital, Padhar, Betul District, Madhya Pradesh 460005, India
    Cleft Palate Craniofac J 43:138-41. 2006
    To assess whether local anesthetic blockade of the infraorbital nerve may allow for cleft lip repair to be performed under regional anesthesia.
  18. ncbi Oral and nasal malodor in patients with and without cleft lip and palate who had undergone orthodontic therapy
    Cenk Doruk
    Department of Orthodontics, University of Cumhuriyet, Sivas, Turkey
    Cleft Palate Craniofac J 45:481-4. 2008
    To compare oral and nasal malodor in patients with and without cleft lip and palate (CLP) who had undergone orthodontic therapy.
  19. ncbi Incidence and outcome of middle ear disease in cleft lip and/or cleft palate
    Patrick Sheahan
    Department of Otolaryngology, The Children s Hospital, Temple Street, 1, Dublin, Ireland
    Int J Pediatr Otorhinolaryngol 67:785-93. 2003
    ..The purpose of the present study was to examine the incidence, natural history, treatment, and outcome of middle ear disease in children with clefts...
  20. ncbi Oral health of individuals with cleft lip, cleft palate, or both
    Elizabeth Maria Bastos Lages
    Federal University of Minas Gerais, Brazil
    Cleft Palate Craniofac J 41:59-63. 2004
    To evaluate the oral health of children with cleft lip and palate.
  21. ncbi Comparison of dental caries prevalence in patients with cleft lip and/or palate and their sibling controls
    Mahmoud Al-Dajani
    College of Dentistry, International University for Science and Technology, Dara, Syria
    Cleft Palate Craniofac J 46:529-31. 2009
    Objective: To evaluate the prevalence of dental caries in patients with cleft lip and/or palate and their cleft-free sibling controls.Methods: The two subject groups (patient and control) comprised 106 participants...
  22. ncbi Facial cleft and associated anomalies: incidence among infants at a Jordanian medical centre
    H E Aqrabawi
    Neonatal Unit, King Hussein Medical Centre, Amman, Jordan
    East Mediterr Health J 14:356-9. 2008
    To estimate incidence of cleft lip and cleft palate among Jordanian infants and to identify associated anomalies, we carried out a prospective, hospital-based study over a 5-year period, January 2000-January 2005...
  23. ncbi Cleft lip and palate
    Peter A Mossey
    Department of Dental and Oral Health, University of Dundee, Dental Hospital and School, Dundee, UK
    Lancet 374:1773-85. 2009
    Clefts of the lip and palate are generally divided into two groups, isolated cleft palate and cleft lip with or without cleft palate, representing a heterogeneous group of disorders affecting the lips and oral cavity...
  24. ncbi Time trends in oral clefts in Chinese newborns: data from the Chinese National Birth Defects Monitoring Network
    Li Dai
    National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Chengdu, 610041, China
    Birth Defects Res A Clin Mol Teratol 88:41-7. 2010
    ..Although the prevalence of oral clefts in China is among the highest in countries worldwide, little is known about its descriptive epidemiology...
  25. ncbi Pattern of cleft lip and palate in hospital-based population in Saudi Arabia: retrospective study
    Aziza Aljohar
    Dentistry Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Cleft Palate Craniofac J 45:592-6. 2008
    To report the patterns of cleft lip and/or cleft palate in Saudi Arabia from data collected at a tertiary care hospital.
  26. ncbi Oral disease status of a sample of Jordanian people ages 10 to 28 with cleft lip and palate
    Ahed Al-Wahadni
    Department of Restorative Dentistry, Faculty of Dentistry, Jordan University of Science and Technology, Irbid, Jordan
    Cleft Palate Craniofac J 42:304-8. 2005
    To determine the levels of periodontal disease and dental caries in subjects with cleft lip and palate and to compare them with matched noncleft control subjects.
  27. ncbi Maternal antioxidant supplementation does not reduce the incidence of phenytoin-induced cleft lip and related malformations in rats
    Dominique Abela
    Department of Anatomy and Histology, University of Sydney, Sydney, Australia
    Birth Defects Res B Dev Reprod Toxicol 74:201-6. 2005
    ..that the antioxidant diet had a significant protective effect, with far fewer antioxidant-group fetuses showing cleft lip or maxillary hypoplasia compared with the control group...
  28. ncbi A longitudinal study on influence of primary facial deformities on maxillofacial growth in patients with cleft lip and palate
    Norifumi Nakamura
    Division of Maxillofacial Diagnostic and Surgical Sciences, Graduate School of Dental Science, Kyushu University, Maidashi, Fukuoka, Japan
    Cleft Palate Craniofac J 42:633-40. 2005
    ..use three-dimensional (3D) analysis to characterize the primary facial deformities in children with unilateral cleft lip and palate (UCLP) and then serially analyze the relationships between facial deformities and maxillofacial ..
  29. ncbi Cleft lip and/or palate: 10 years experience at a pediatric cleft center in Southern Thailand
    Somchit Jaruratanasirikul
    Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand
    Cleft Palate Craniofac J 45:597-602. 2008
    To study the clinical characteristics, demographic data, and associated congenital anomalies of pediatric patients with cleft lip and/or palate in Southern Thailand.
  30. ncbi Cleft lip and palate in southwestern Iran: an epidemiologic study of live births
    Mohammad Hossain Rajabian
    Shiraz University of Medical Sciences, Department of Plastic Surgery, Shiraz, Iran
    Ann Saudi Med 25:385-8. 2005
    BACKGROUND: Cleft lip with or without cleft palate (CL/P), is the most common congenital anomaly in the head and neck worldwide. We studied the prevalence of cleft lip (CL) and palate (CP) in Shiraz, which is located in southwestern Iran...
  31. ncbi Evaluation of oral and nasal halitosis parameters in patients with repaired cleft lip and/or palate
    Flávio Monteiro-Amado
    Hospital for Rehabilitation of Craniofacial Anomalies, Universidade of São Paulo, and Master of Science in Stomatology by Bauru Dental School, Universidade of São Paulo, Bauru, Brazil
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100:682-7. 2005
    The objective of this study was to investigate the relationship between halitosis parameters in patients with and without cleft lip and/or palate.
  32. ncbi Evaluation of oral and nasal odor in patients with and without cleft lip and palate: preliminary report
    Flávio Monteiro-Amado
    Hospital for Rehabilitation of Craniofacial Anomalies, University of Sao Paulo, Bauru, Brazil
    Cleft Palate Craniofac J 41:661-3. 2004
    ..To evaluate oral and nasal halitosis parameters in patients with and without clefts...
  33. ncbi Factors influencing early childhood caries of cleft lip and/or palate children aged 18 to 36 months in southern Thailand
    Teerapong Mutarai
    Orthodontic Division, Department of Preventive Dentistry, Prince of Songkhla University, Thailand
    Cleft Palate Craniofac J 45:468-72. 2008
    ..To clarify whether oral health care behavior or oral cleft status influences early childhood caries in southern Thailand cleft children...
  34. ncbi Does repairing a cleft lip neonatally have any effect on the longer-term attractiveness of the repair?
    Tim E E Goodacre
    Department of Plastic Surgery, Radcliffe Infirmary, Oxford, United Kingdom
    Cleft Palate Craniofac J 41:603-8. 2004
    To determine whether attractiveness and success of surgical outcome differ according to the timing of cleft lip repair.
  35. ncbi Cleft lip and palate: association with other congenital malformations
    Soraya Beriaghi
    Cleft Palate and Craniofacial Clinic, Division of Pediatric Dentistry School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA
    J Clin Pediatr Dent 33:207-10. 2009
    ..Orofacial clefts are frequently associated with other congenital malformations. Studies vary in incidence and types of anomalies...
  36. ncbi Craniofacial computerized tomography analysis of the midface of patients with repaired complete unilateral cleft lip and palate
    Sunjay Suri
    Discipline of Orthodontics, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
    Am J Orthod Dentofacial Orthop 134:418-29. 2008
    ..the maxillary dentoalveolar and deeper structures in patients with surgically repaired complete unilateral cleft lip and palate (CLP) and to investigate whether significant asymmetry existed in the deeper midfacial structures, ..
  37. ncbi Preferential associations between oral clefts and other major congenital anomalies
    Monica Rittler
    ECLAMC Latin American Collaborative Study of Congenital Malformations at Hospital Materno Infantil Ramón Sardá, Buenos Aires, Argentina
    Cleft Palate Craniofac J 45:525-32. 2008
    To identify preferential associations between oral clefts (CL = cleft lip only, CLP = cleft lip with cleft palate, CP = cleft palate) and nonoral cleft anomalies, to interpret them on clinical grounds, and, based on the patterns of ..
  38. ncbi Wnt9b is the mutated gene involved in multifactorial nonsyndromic cleft lip with or without cleft palate in A/WySn mice, as confirmed by a genetic complementation test
    Diana M Juriloff
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    Birth Defects Res A Clin Mol Teratol 76:574-9. 2006
    Nonsyndromic cleft lip (CL) with or without cleft palate (CLP) is a common human birth defect with complex genetic etiology. One of the unidentified genes maps to chromosome 17q21...
  39. ncbi Epidemiology underpinning research in the aetiology of orofacial clefts
    Peter Mossey
    University of Dundee, Dental Hospital and School, Dundee, Scotland, UK
    Orthod Craniofac Res 10:114-20. 2007
    ..The next steps for IPDTOC are to expand the number of participating registries and to actively collect data on other craniofacial birth defects...
  40. ncbi Dental health indices and caries associated microflora in children with unilateral cleft lip and palate
    V S Lucas
    Department of Oral Medicine, Eastman Dental Institute, University of London, England
    Cleft Palate Craniofac J 37:447-52. 2000
    To investigate the dental health and caries related microflora of children with unilateral cleft lip and palate.
  41. ncbi Evaluation of maxillary alveolar reconstruction using a resorbable collagen sponge with recombinant human bone morphogenetic protein-2 in cleft lip and palate patients
    Nivaldo Alonso
    Division of Plastic Surgery, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Tissue Eng Part C Methods 16:1183-9. 2010
    ..A resorbable collagen matrix with recombinant human bone morphogenetic protein (rhBMP-2) was compared with traditional iliac crest bone graft for the closure of alveolar defects during secondary dental eruption...
  42. ncbi [Caries, gingivitis and dental abnormalities in patients with cleft lip and palate]
    M Budai
    , Szeged
    Fogorv Sz 94:197-9. 2001
    Oral health was studied in 31 children aged 10-12 years with cleft lip and palate and compared to 31 noncleft controls matched for sex and age...
  43. ncbi Caries prevalence in children with cleft lip and palate--a systematic review of case-control studies
    Pamela Hasslöf
    Department of Odontology, Pediatic Dentistry, Faculty of Medicine, Umea University, Umea, Sweden
    Int J Paediatr Dent 17:313-9. 2007
    To conduct a systematic review of literature in order to examine the evidence of an increased prevalence of dental caries in children with cleft lip and palate (CLP).
  44. ncbi MMP gene polymorphisms as contributors for cleft lip/palate: association with MMP3 but not MMP1
    Ariadne Letra
    Department of Biological Sciences, Bauru Dental School, University of Sao Paulo, Brazil
    Arch Oral Biol 52:954-60. 2007
    ..MMPs can be considered a group of candidate proteins for the etiology of cleft lip with or without cleft palate (CL/P) due to their role in craniofacial modelling...
  45. ncbi Expression and association data strongly support JARID2 involvement in nonsyndromic cleft lip with or without cleft palate
    Luca Scapoli
    Department of Histology, Embryology and Applied Biology, Centre of Molecular Genetics, University of Bologna, Via Belmeloro, 8, 40126 Bologna, Italy
    Hum Mutat 31:794-800. 2010
    Nonsyndromic cleft lip with or without cleft palate (CL/P) affects approximately 1 in 1,000 births...
  46. ncbi Cleft lip and palate care in the United Kingdom--the Clinical Standards Advisory Group (CSAG) Study. Part 3: speech outcomes
    D Sell
    Department of Speech and Language Therapy at the Great Ormond Street Hospital for Children, London, England
    Cleft Palate Craniofac J 38:30-7. 2001
    To summarize speech outcomes in children born with unilateral cleft lip and palate (UCLP) throughout the United Kingdom.
  47. ncbi Secondary alveolar bone grafting in cleft lip and palate patients
    L C Newlands
    Northern Ireland Regional Plastic and Maxillofacial Unit, The Ulster Hospital, Dundonald, Belfast, Northern Ireland
    Br J Oral Maxillofac Surg 38:488-91. 2000
    ..Bone levels were assessed on a four-point scale. Of 64 canines fully erupted in 94 clefts, 91% achieved bone levels of Type I or II and only two grafts failed. The outcome was more favourable when the canine was unerupted preoperatively...
  48. ncbi Susceptibility locus for non-syndromic cleft lip with or without cleft palate on chromosome 10q25 confers risk in Estonian patients
    Tiit Nikopensius
    Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
    Eur J Oral Sci 118:317-9. 2010
    Non-syndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common birth defects and has a multifactorial etiology that includes both genetic and environmental factors...
  49. ncbi Cleft deformities in Zimbabwe, Africa: socioeconomic factors, epidemiology, and surgical reconstruction
    Annette M Pham
    Cleft and Craniofacial Program, Facial Plastic and Reconstructive Surgery, Department of Otolaryngology Head and Neck Surgery, University of California, Davis School of Medicine, 2521 Stockton Blvd, Sacramento, CA 95817, USA
    Arch Facial Plast Surg 9:385-91. 2007
    ..Although cleft lip and palate has a lower incidence in Africa (0...
  50. ncbi Dental caries prevalence in children with cleft lip/palate aged between 6 months and 6 years in the West of Scotland
    K F M Britton
    Department of Paediatric Dentistry, Glasgow Dental Hospital and School, 378 Sauchiehall Street, Glasgow, Scotland, G2 3JZ
    Eur Arch Paediatr Dent 11:236-41. 2010
    To compare the prevalence of dental caries in children with cleft lip/palate with national data at the same age.
  51. ncbi Dental and oral hygiene status in Jordanian children with cleft lip and palate: a comparison between unilateral and bilateral clefts
    A M Hazza'a
    Department of Oral Medicine and Oral Surgery, Jordan University of Science and Technology, Irbid, Jordan
    Int J Dent Hyg 9:30-6. 2011
    The purpose of this study was to assess and compare the dental health and oral hygiene status of subjects with unilateral and bilateral cleft lip and palate (BCLP).
  52. ncbi Genetic origins in a South American clefting population
    A R Vieira
    Department of Pediatrics, University of Iowa, Iowa City 52242-1083, USA
    Clin Genet 62:458-63. 2002
    ..The implications of this finding include the possibility of using admixture mapping approaches to this population...
  53. ncbi Human genetic factors in nonsyndromic cleft lip and palate: an update
    Francesco Carinci
    Department of D M C C C, Section of Maxillofacial Surgery, University of Ferrara, Corso, Giovecca 203, 44100 Ferrara, Italy
    Int J Pediatr Otorhinolaryngol 71:1509-19. 2007
    Nonsyndromic cleft lip and/or palate (or orofacial cleft, OFC) is a malformation characterized by an incomplete separation between nasal and oral cavities without any associated anomalies...
  54. ncbi A long-term, controlled-outcome analysis of in utero versus neonatal cleft lip repair using an ovine model
    E J Stelnicki
    Institute of Reconstructive and Plastic Surgery at New York University Medical Center, NY 10016, USA
    Plast Reconstr Surg 104:607-15. 1999
    Successful open repair of a cleft lip in utero has the advantage of scarless wound healing in the fetus. Unfortunately, no long-term outcome studies have been performed to evaluate the efficacy of these repairs...
  55. ncbi The incidence of cleft lip, cleft palate, hydrocephalus and spina bifida at Queen Elizabeth Central Hospital, Blantyre, Malawi
    B C Msamati
    Department of Anatomy, College of Medicine, University of Malawi, Blantyre
    Cent Afr J Med 46:292-6. 2000
    To determine the incidence of cleft lip, cleft palate, spina bifida and hydrocephalus; and to compare these with those of Asian and European subjects.
  56. ncbi Epidemiological and genetic study of 121 cases of oral clefts in Kuwait
    S A al-Bustan
    Department of Biological Sciences, Faculty of Science, Kuwait University, PO Box 5969, Safat 13060, Kuwait
    Orthod Craniofac Res 5:154-60. 2002
    ..study was to ascertain some epidemiological factors such as sex and consanguinity that may be associated with cleft lip with or without cleft palate (CL +/- CP) in Kuwait as well as to conduct genetic segregation analysis of these ..
  57. ncbi Botulinum toxin to improve results in cleft lip repair
    Travis T Tollefson
    Department of Otolaryngology-Head and Neck Surgery, University of California, Davis Medical Center, Sacramento 95817, USA
    Arch Facial Plast Surg 8:221-2. 2006
  58. ncbi Tissue engineering solutions for cleft palates
    Jennifer L Moreau
    Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, MD, USA
    J Oral Maxillofac Surg 65:2503-11. 2007
    ..Clefts of the lip and palate are the most prevalent congenital craniofacial birth defect in humans. The developing field of tissue engineering is considered for the management of clefts of the lip and palate...
  59. ncbi Asymmetry of the craniofacial skeleton in the parents of children with a cleft lip, with or without a cleft palate, or an isolated cleft palate
    G T McIntyre
    Orthodontic Department, University of Dundee Dental Hospital and School, UK
    Eur J Orthod 32:177-85. 2010
    The objective of this study was to evaluate asymmetry of the parental craniofacial skeleton of subjects with a cleft lip, with or without cleft palate [CL(P)], and isolated cleft palate (CP)...
  60. ncbi Prevalence of nonsyndromic oral clefts in a reference hospital in the state of Minas Gerais, Brazil, between 2000-2005
    Hercilio Martelli Junior
    School of Dentistry, State University of Montes Claros, Brazil
    Braz Oral Res 21:314-7. 2007
    ..3. Males were 2.57 times more affected by cleft lip and palate (CLP) than females. CLP with a prevalence of 39...
  61. ncbi Outcome of secondary alveolar bone grafting before and after eruption of the canine in Jordanian patients with cleft lip and palate
    Ma amon A Rawashdeh
    Department of Oral and Maxillofacial Surgery, Jordan University of Science and Technology and King Abdullah University Hospital, Cleft Lip and Palate Centre, Irbid, Jordan
    J Craniofac Surg 18:1331-7. 2007
    This prospective study was carried out at the Cleft Lip and Palate Centre at King Abdullah University Hospital and Maxillofacial Unit at Jordan University of Science and Technology during the period of 2000 to 2006...
  62. ncbi Congenital missing permanent teeth in Korean unilateral cleft lip and alveolus and unilateral cleft lip and palate patients
    Seung Hak Baek
    School of Dentistry, Dental Research Institute, Seoul National University, Department of Orthodontics, Seoul, South Korea
    Angle Orthod 77:88-93. 2007
    ..maxillary lateral incisor [MLI] and maxillary second premolar [MSP]) and sidedness (cleft vs noncleft) between boys and girls in Korean unilateral cleft lip and alveolus (UCLA) and unilateral cleft lip and palate (UCLP) patients.
  63. ncbi Dentocraniofacial morphology of 21 patients with unilateral cleft lip and palate: a cephalometric study
    Miranda Corbo
    Department of Maxillofacial Surgery, Queen Fabiola University Children's Hospital, , Brussels, Belgium
    Cleft Palate Craniofac J 42:618-24. 2005
    OBJECTIVE: To assess the skeletal and dental craniofacial proportions of unilateral cleft lip and palate patients who were operated upon using the Malek technique, and compare them with a normal group to highlight the effect of surgical ..
  64. ncbi Long-term evaluation of bilateral cleft lip and palate patients after early secondary closure and premaxilla repositioning
    C T M Geraedts
    Department of Oral and Maxillofacial Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Oral Maxillofac Surg 36:788-96. 2007
    ..study was to assess the long-term outcome of early secondary closure and premaxilla osteotomy in 40 bilateral cleft lip and palate patients who underwent early secondary osteotomy of the premaxilla and bone grafting at the age of 8-..
  65. ncbi Three-dimensional facial morphology following surgical repair of unilateral cleft lip and palate in patients after nasoalveolar molding
    G D Singh
    Department of Speech and Hearing Sciences, Portland State University, Portland, OR 97207 0751, USA
    Orthod Craniofac Res 10:161-6. 2007
    To evaluate three-dimensional (3D) facial morphology in patients surgically corrected for unilateral cleft lip and palate (UCLP) following pre-surgical nasoalveolar molding (NAM).
  66. ncbi Long-term maxillomandibular skeletal and dental changes in children with cleft lip and palate after maxillary distraction
    Kiyoshi Harada
    Dentistry and Oral Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:292-9. 2006
    Long-term skeletal and dental changes were examined in 8 children with cleft lip and palate who underwent maxillary distraction to allow the maxilla to catch up to their mandibular growth at the treatment point...
  67. ncbi Craniofacial characteristics evidenced in Bartsocas-Papas syndrome from birth to five years. Case report
    Anthony L Maganzini
    Montefiore Medical Center, University Hospital for the Albert Einstein College of Medicine, Bronx, USA
    N Y State Dent J 72:34-7. 2006
    ..However, oral, facial, cranial and dental anomalies are often overlooked. This case focuses on the latter anomalies and the effect they have on the facial growth of a 5-year-old patient...
  68. ncbi An uncommon cleft subtype of unilateral cleft lip and palate
    T Yamanishi
    First Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, Osaka, Japan
    J Dent Res 87:164-8. 2008
    ..the vomer plays a crucial role in maxillary growth suggests that the bilateral cleft configuration of unilateral cleft lip and palate (UCLP), in which the vomer is detached from the non-cleft-side secondary hard palate, negatively ..
  69. ncbi Maxillary and sella turcica morphology in newborns with cleft lip and palate
    Bo Werner Nielsen
    Department of Orthodontics, School of Dentistry, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Cleft Palate Craniofac J 42:610-7. 2005
    ..fields by analyzing bone size parameters within the maxillary bone complex in newborns with unilateral cleft lip (UCL) and unilateral cleft lip and palate (UCLP)...
  70. ncbi Symmetry of the nose after presurgical nasoalveolar molding in infants with unilateral cleft lip and palate: a preliminary study
    Betty Chien-Jung Pai
    Chang Gung Memorial Hospital and Chang Gung University, Taipei, Taiwan
    Cleft Palate Craniofac J 42:658-63. 2005
    OBJECTIVE: To assess nostril symmetry and alveolar cleft width in infants with unilateral cleft lip and palate following presurgical nasoalveolar molding (NAM)...
  71. ncbi Presurgical orthopaedic treatment of newborns with clefts--functional treatment with long-term effects
    Rosemarie Grabowski
    Department of Orthodontics, University of Rostock, Germany
    J Craniomaxillofac Surg 34:34-44. 2006
    ..Presurgical orthopaedic treatment aims at reduction of cleft size by guiding growth and functional rehabilitation. Long-term results of maxillary development and occlusion at young adult age are reported...
  72. ncbi Assessment of arch constriction in patients with bilateral cleft lip and palate and isolated cleft palate: a pilot study
    Catherine Tothill
    Orthodontic Department, Dundee Hospital and School, Scotland, UK
    Eur J Orthod 29:193-7. 2007
    ..of this study was to test the use of the modified Huddart/Bodenham scoring system on patients with a bilateral cleft lip and palate (BCLP) or an isolated cleft palate (CP)...
  73. ncbi Sagittal growth of the facial skeleton of 6-year-old children with a complete unilateral cleft of lip, alveolus and palate treated with two different protocols
    Wolfgang Zemann
    Department of Oral and Maxillofacial Surgery, University Hospital Graz, Austria
    J Craniomaxillofac Surg 35:343-9. 2007
    ..The purpose of the study was to compare sagittal growth of the facial skeleton of 6-year-old children treated in two cleft centres with different surgical protocols...
  74. ncbi Unilateral complete cleft lip and palate repair using lip adhesion combined with a passive intraoral alveolar molding appliance: surgical results and the effect on the maxillary alveolar arch
    Byung Chae Cho
    Department of Plastic and Reconstructive Surgery, Kyungpook National University Hospital, Daegu, Korea
    Plast Reconstr Surg 117:1510-29. 2006
    A number of combined maxillary orthopedic and surgical treatment protocols have been proposed for the initial phase of therapy for infants with a complete cleft lip and palate.
  75. ncbi Infant orthopedics has no effect on maxillary arch dimensions in the deciduous dentition of children with complete unilateral cleft lip and palate (Dutchcleft)
    Catharina A M Bongaarts
    Department of Orthodontics and Oral Biology, Radboud University Nijmegen Medical Center, 309 Tandheelkunde, 6500 HB Nijmegen, The Netherlands
    Cleft Palate Craniofac J 43:665-72. 2006
    ..effect of infant orthopedics on maxillary arch dimensions in the deciduous dentition in patients with unilateral cleft lip and palate...
  76. ncbi Review of the UCL management of patients with cleft lip and palate
    S Castelein
    Cleft lip and palate centre A de Coninck, University Hospital Saint Luc, Brussels, Belgium
    B-ENT 2:51-6. 2006
    ..Since 1987, we have opted for the neonatal repair of the cleft lip and nose, and closure of the cleft palate at three months of age...
  77. ncbi Correction of the alveolar gap and nostril deformity by presurgical passive orthodontia in the unilateral cleft lip
    Marcos Jaeger
    Department of Plastic Surgery, Hospital for Sick Children, Toronto, Canada
    Ann Plast Surg 59:489-94. 2007
    ..NAM constitutes an important adjunct to ameliorate the results of primary definitive lip repair while also improving the surgeon's ability to provide nasal symmetry...
  78. ncbi Assessment of cleft lip and palate patients treated with presurgical orthopedic correction and either primary bone grafts, gingivoperiosteoplasty, or without alveolar grafting procedures
    Thomas M Grisius
    University of Detroit Mercy, Department of Orthodontics, Detroit, Michigan, USA
    J Craniofac Surg 17:468-73. 2006
    ..The present work evaluates and compares facial form at age six years in complete unilateral cleft lip and palate patients treated with presurgical orthopedic correction and primary reconstruction with (1) primary ..
  79. ncbi Long-term follow-up after maxillary distraction osteogenesis in growing children with cleft lip and palate
    Chiung Shing Huang
    Craniofacial Center, Faculty of Dentistry, Chang Gung Memorial Hospital, Taipei, Taiwan
    Cleft Palate Craniofac J 44:274-7. 2007
    To evaluate the changes in maxillary position after maxillary distraction osteogenesis in six growing children with cleft lip and palate.
  80. ncbi Cephalometric evaluation of long-term craniofacial development in unilateral cleft lip and palate patients treated with delayed hard palate closure
    P J P M Nollet
    Department of Orthodontics and Oral Biology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Oral Maxillofac Surg 37:123-30. 2008
    ..cephalometric study aimed to evaluate the craniofacial development of patients with a complete unilateral cleft lip and palate treated with a two-stage palatal closure, including delayed closure of the hard palate...
  81. ncbi Vertical development of the cleft segments in infants with bilateral cleft lip and palate: effect of dentofacial orthopedic and surgical treatment on maxillary morphology from birth to the age of 11 months
    Juliane Dürwald
    Department of Orthodontics, University of Leipzig, Leipzig, Germany
    J Orofac Orthop 68:183-97. 2007
    ..graphically demonstrate the clinically-visible vertical deviation of the premaxilla and lateral segments from a defined reference plane, and to describe the effect of presurgical dentofacial orthopedic treatment and cleft lip operation.
  82. ncbi Effects of lip repair on maxillary growth and facial soft tissue development in patients with a complete unilateral cleft of lip, alveolus and palate
    Yang Li
    Department of Oral and Maxillofacial Surgery, Sichuan University, People's Republic of China
    J Craniomaxillofac Surg 34:355-61. 2006
    ..and photographs (anterior-posterior and profile) were taken for 3 groups of patients: (1) 35 complete unilateral cleft lip, alveolus and palate cases in whom only a labioplasty was performed as infants; (2) 47 cases who had both lip ..
  83. ncbi Changes in nasorespiratory function in association with maxillary distraction osteogenesis in subjects with cleft lip and palate
    Kiyo Saito
    Maxillofacial Orthognathics, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Cleft Palate Craniofac J 43:75-83. 2006
    ..SUBJECTS: Data from 13 subjects with cleft lip and palate were used...
  84. ncbi Maxillary protraction effects on anterior crossbites. Repaired unilateral cleft versus noncleft prepubertal boys
    Haichao Jia
    Department of Orthodonticsm School of Stomatology, Capital Medical University, Beijing, China
    Angle Orthod 78:617-24. 2008
    To test the hypothesis that there is no difference between the effects of maxillary protraction on anterior crossbites in repaired unilateral cleft lip and palate (UCLP) and noncleft prepubertal boys.
  85. ncbi [A functional approach in the primary treatment of labial-alveolar-velopalatine clefts for a minimum of sequels]
    J C Talmant
    Clinique Jules Verne, 2 4, Route de Paris, 44300 Nantes, France
    Rev Stomatol Chir Maxillofac 108:255-63. 2007
    ..In this ambitious and demanding program, the patient comes first; we decrease the burden for him and his family, and give them the benefit of a good social life before school age...
  86. ncbi Presurgical nasoalveolar molding therapy for the treatment of unilateral cleft lip and palate: a preliminary study
    Christopher F Ezzat
    Department of Pediatrics, The University of Texas Health Science Center, Houston, Texas, USA
    Cleft Palate Craniofac J 44:8-12. 2007
    ..To evaluate the outcome of presurgical nasoalveolar molding (PNAM) therapy in the treatment of patients with nonsyndromic unilateral cleft and palate (UCLP)...
  87. ncbi Craniofacial development in children with unilateral cleft lip and palate
    Servet Doğan
    Ege University School of Dentistry, Department of Orthodontics, Bornova, Izmir, Turkey
    Br J Oral Maxillofac Surg 44:28-33. 2006
    Unilateral cleft lip and palate is the most common cleft in humans...
  88. ncbi Hypoplasia and hypodontia in Van der Woude syndrome
    Snehlata Oberoi
    Center for Craniofacial Anomalies, School of Dentistry, University of California, San Francisco, 94143-0640, USA
    Cleft Palate Craniofac J 42:459-66. 2005
    ..AND PARTICIPANTS: The sample consisted of 15 individuals with Van der Woude syndrome and 15 nonsyndromic cleft lip and/or palate controls paired for age, gender, and cleft type in the age range of 5 to 13 years...
  89. ncbi Long-term results in maxillary deficiency using intraoral devices
    A Rachmiel
    Department of Oral and Maxillofacial Surgery, Rambam Medical Center, Haifa, Israel
    Int J Oral Maxillofac Surg 34:473-9. 2005
    b>Cleft lip and palate patients often present maxillary retrusion and class III malocclusion after cleft repair. Maxillary distraction is a technique that can provide simultaneous skeletal advancement and expansion of soft tissue...
  90. ncbi A cephalometric study of facial growth in van der Woude syndrome
    Alex A Kane
    Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taipei, Taiwan
    Cleft Palate Craniofac J 39:219-25. 2002
    ..and lower lip form in patients with van der Woude syndrome (VDW) is different from patients with non-syndromic cleft lip and palate...
  91. ncbi Palate height: another indicator of surgical outcome in unilateral cleft lip and palate?
    Om P Kharbanda
    Division of Orthodontics, Department of Dental Surgery, All India Institute of Medical Sciences New Delhi, India
    Cleft Palate Craniofac J 39:308-11. 2002
    To determine whether palate height and maxillary arch depth are systematically related to the surgical center at which primary repair in unilateral cleft lip and palate (UCLP) was carried out.
  92. ncbi Analysis of nasal and labial deformities in cleft lip, alveolus and palate patients by a new rating scale: preliminary report
    Y Anastassov
    Plastic and Craniofacial Unit, Medical Institute of Plovdiv, Bulgaria
    J Craniomaxillofac Surg 31:299-303. 2003
    In this study the nasal deformities in patients with cleft lip, alveolus and palate (CLAP) were analysed and the relevant role of the perinasal-perioral muscular balance, and the inborn dislocation of the alar cartilages is presented.
  93. ncbi Repair of bilateral cleft lip: review, revisions, and reflections
    John B Mulliken
    Children's Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Craniofac Surg 14:609-20. 2003
    Rarely does the appearance of a child with a repaired bilateral cleft lip compare favorably with that of a child with a repaired unilateral cleft lip...
  94. ncbi Association of nasomaxillary asymmetry in children with unilateral cleft lip and palate and their parents
    Young-Jooh Yoon
    Eastman Department of Dentistry, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14620, USA
    Cleft Palate Craniofac J 40:493-7. 2003
    ..this study was to evaluate the association of transverse craniofacial asymmetry between children with unilateral cleft lip and palate (UCLP) and their parents...
  95. ncbi The effects of active infant orthopedics on occlusal relationships in unilateral complete cleft lip and palate
    Kathleen T Chan
    Department of Growth and Development, Harvard School of Dental Medicine, Boston, MA, USA
    Cleft Palate Craniofac J 40:511-7. 2003
    ..dental arch relationships and determine the effect on maxillary growth in children born with unilateral complete cleft lip and palate (UCCLP)...
  96. ncbi Long-term results of the two-stage palatoplasty/Hotz' plate approach for complete bilateral cleft lip, alveolus and palate patients
    Alcibiades E Silvera Q
    Division of Orthodontics, Department of Oral Biological Science, Course for Oral Life Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata City, Japan
    J Craniomaxillofac Surg 31:215-27. 2003
    ..To investigate the effects of the two-stage palatoplasty combined with the Hotz' plate on craniofacial development in patients with bilateral complete clefts...
  97. ncbi Patterns of maxillary alveolar arch growth changes of infants with unilateral cleft lip and palate: preliminary findings
    Bert Braumann
    Department of Orthodontics, Clinic for Oral and Maxillofacial Surgery, Center for Dentistry, University of Bonn, Bonn, Germany
    Cleft Palate Craniofac J 40:363-72. 2003
    ..Can reaction patterns be extracted from changes in maxillary dimensions of different cleft forms within the first year of life to support this hypothesis?..
  98. ncbi Occlusal relationship in patients with bilateral cleft lip and palate during the mixed dentition stage: does neonatal maxillary arch configuration predetermine outcome?
    Chad A Perlyn
    Cleft Palate and Craniofacial Deformities Institute, St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Cleft Palate Craniofac J 39:317-21. 2002
    To determine whether there is any correlation between initial maxillary arch dysmorphology patterns in complete bilateral cleft lip/palate (BCLP) and the subsequent occlusal relationship in early mixed dentition.
  99. ncbi Effects of cheiloplasty on maxillary dental arch development in infants with unilateral complete cleft lip and palate
    Chiung Shing Huang
    Faculty of Dentistry, Chang Gung Memorial Hospital, Taipei, Taiwan, ROC
    Cleft Palate Craniofac J 39:513-6. 2002
    ..To identify and analyze quantitatively the development of the maxillary dental arch before and after cheiloplasty...
  100. ncbi Analysis of midface asymmetry in patients with cleft lip, alveolus and palate at the age of 3 months using 3D-COSMOS measuring system
    W Zemann
    Department of Oral and Maxillofacial Surgery, University Clinic of Dentistry, Medical School University of Graz, Austria
    J Craniomaxillofac Surg 30:148-52. 2002
    Patients suffering from unilateral cleft lip, alveolus and palate exhibit a varying degree of asymmetry of the midface. Evaluation of this asymmetry can be carried out by means of 3D-CT, or a laser surface scanner.
  101. ncbi Changes in soft tissue thickness after Le Fort I osteotomy in different cleft types
    A Heliövaara
    Cleft Center, Department of Plastic Surgery, Helsinki University Central Hospital, Finland
    Int J Adult Orthodon Orthognath Surg 16:207-13. 2001
    ..5 years); 10 patients with bilateral cleft lip and palate (BCLP, mean age 21.7 years); and 26 patients with unilateral cleft lip and palate (UCLP, mean age 22...

Research Grants79

  1. Quality of Life in Children with Cleft
    Hillary L Broder; Fiscal Year: 2010
    ..This project will enroll children (ages 8-17) with cleft palate only (CPO) and cleft lip and palate and their caregivers who are evaluated at five renown craniofacial centers (two in the southeast and ..
  2. Quality of Life in Children with Cleft
    Hillary L Broder; Fiscal Year: 2010
    ..This project will enroll children (ages 8-17) with cleft palate only (CPO) and cleft lip and palate and their caregivers who are evaluated at five renown craniofacial centers (two in the southeast and ..
  3. Quality of Life in Children with Cleft
    Hillary Broder; Fiscal Year: 2009
    ..This project will enroll children (ages 8-17) with cleft palate only (CPO) and cleft lip and palate and their caregivers who are evaluated at five renown craniofacial centers (two in the southeast and ..
  4. INTERNATIONAL GENETIC EPIDEMIOLOGY OF ORAL CLEFTS
    Terri Beaty; Fiscal Year: 2009
    ..we successfully conducted a multi-center, international study on the genetic etiology of oral clefts (including cleft lip, CL; cleft lip and palate, CLP; and cleft palate, CP) by recruiting cases from 5 sites (Maryland, Singapore, ..
  5. Effects of oral clefts on birth outcomes and cleft risks due to maternal smoking
    GEORGE WEHBY; Fiscal Year: 2007
    b>Cleft lip and/or palate (CL/P) is a common birth defect with a complex ideology and large health burden. The effects of CL/P on birth outcomes such as low birth weight and prematurity have been understudied...
  6. Health outcomes and improved phenotypic characterization of cleft lip and palate
    GEORGE WEHBY; Fiscal Year: 2007
    b>Cleft lip and/or palate (CLP) is a common birth defect occurring in about 1/500 to 1/2500 births...
  7. Health outcomes and improved phenotypic characterization of cleft lip and palate
    GEORGE WEHBY; Fiscal Year: 2009
    b>Cleft lip and/or palate (CLP) is a common birth defect occurring in about 1/500 to 1/2500 births...
  8. Effects of Dioxin on Vietnamese Civilians
    David Carpenter; Fiscal Year: 2004
    ..These hospitals serve maternity patients from all of southern Vietnam. The investigators will study cases of a) cleft lip/cleft palate, b) neural tube defects, including spina bifida, anecephaly and microcephaly, and c) limb ..
  9. Speech Intelligibility Testing in Children with Repaired Cleft Palate
    David Zajac; Fiscal Year: 2007
    ..underlie speech intelligibility in young children with repaired clefts of the secondary palate with or without cleft lip (Aim 1)...
  10. Eustachian Tube Form/Function in Cleft Lip and Palate
    Anil Gungor; Fiscal Year: 2004
    ..If these predictions are valid, an early MRI study of CP infants be prognostic of the severity and longevity of ME disease and may serve to guide the type of palatal reconstruction for individual patients. ..
  11. VELOPHARYNGEAL FUNCTION FOR SPEECH AFTER PALATAL SURGERY
    William Williams; Fiscal Year: 2004
    The incidence of cleft lip/palate is 1/750, making it one of the most common congenital malformations...
  12. Skin Regeneration: Cellular & Molecular Mechanisms
    HERMANN PETER LORENZ; Fiscal Year: 2010
    b>Cleft lip and palate is a major health problem because of the functional defect produced. Furthermore, surgical reconstruction results in lip and palate scarring, which inhibits facial growth and oral function...
  13. Functional Outcomes of Cleft Lip Surgery
    CARROLL TROTMAN; Fiscal Year: 2004
    DESCRIPTION: (from the abstract) The prevalence of cleft lip and palate in the United States is approximately 1 in 1000 live births (range of 0.7 to 1.3)...
  14. Gene-enviornment interactions in facial clefts
    Kaare Christensen; Fiscal Year: 2006
    ..Family and twin studies have clearly indicated a genetic role in the etiology of cleft lip and palate, but environmental components play a major role, as well...
  15. Skin Regeneration: Cellular & Molecular Mechanisms
    HERMANN LORENZ; Fiscal Year: 2009
    b>Cleft lip and palate is a major health problem because of the functional defect produced. Furthermore, surgical reconstruction results in lip and palate scarring, which inhibits facial growth and oral function...
  16. Cleft Lip Genetics: A Multicenter International Consorti
    Andrew Lidral; Fiscal Year: 2004
    b>Cleft lip with or without cleft palate (CL/P) is a common birth defect. Previous studies have indicated that CL/P is a complex trait that is caused by a combination of genetic and environmental factors...
  17. CLONING AND CHARACTERIZATION OF THE VAN DER WOUDE GENE
    Brian Schutte; Fiscal Year: 2007
    b>Cleft lip and palate is a common congenital anomaly with significant lifelong morbidity. The extensive psychological, surgical, speech and dental involvement emphasize the importance of understanding the underlying causes...
  18. MOLECULAR GENETIC EPIDEMIOLOGY OF CLEFT LIP AND PALATE
    Jeffrey Murray; Fiscal Year: 1993
    ..funding cycle of this proposal the investigators applied these techniques to a common sentinel birth defect--cleft lip and palate...
  19. Growth Factor Signaling in Mouse Palatogensis
    YiPing Chen; Fiscal Year: 2010
    Non-syndromic cleft lip and cleft palate, one of the major groups of congenital birth defects in human beings...
  20. MOLECULAR GENETIC EPIDEMIOLOGY OF CLEFT LIP AND PALATE
    Jeffrey Murray; Fiscal Year: 2003
    ..Finally, using an affected pedigree member approach, we have mapped a locus for non-syndromic cleft lip and palate to 6p23...
  21. Growth Factor Signaling in Mouse Palatogensis
    YiPing Chen; Fiscal Year: 2009
    Non-syndromic cleft lip and cleft palate, one of the major groups of congenital birth defects in human beings...