cleft lip

Summary

Summary: Congenital defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences. It is thought to be caused by faulty migration of the mesoderm in the head region.

Top Publications

  1. ncbi The prevalence of caries in children with a cleft lip and/or palate in Southern Vietnam
    Sjobbe Besseling
    Department of Oral and Maxillofacial Surgery, Vrije Universiteit, Amsterdam, The Netherlands
    Cleft Palate Craniofac J 41:629-32. 2004
  2. ncbi Cleft lip and palate
    Peter A Mossey
    Department of Dental and Oral Health, University of Dundee, Dental Hospital and School, Dundee, UK
    Lancet 374:1773-85. 2009
  3. pmc Disruption of an AP-2alpha binding site in an IRF6 enhancer is associated with cleft lip
    Fedik Rahimov
    Department of Pediatrics, University of Iowa, 2182 ML, S Grand Ave, Iowa City, Iowa 52242, USA
    Nat Genet 40:1341-7. 2008
  4. pmc Cleft lip and palate: understanding genetic and environmental influences
    Michael J Dixon
    Faculty of Medical and Human Sciences, Manchester Academic Health Sciences Centre, Michael Smith Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Nat Rev Genet 12:167-78. 2011
  5. ncbi MSX1 and TGFB3 contribute to clefting in South America
    A R Vieira
    Departments of Pediatrics, 2613 JCP, University of Iowa, Iowa City, 52242 1083, USA
    J Dent Res 82:289-92. 2003
  6. pmc A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4
    Terri H Beaty
    Johns Hopkins University, School of Public Health, Baltimore, Maryland, USA
    Nat Genet 42:525-9. 2010
  7. doi Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate
    Elisabeth Mangold
    Institute of Human Genetics, Life and Brain Center, University of Bonn, Bonn, Germany
    Nat Genet 42:24-6. 2010
  8. ncbi Gene/environment causes of cleft lip and/or palate
    J C Murray
    Department of Pediatrics, University of Iowa, Iowa City 52242, USA
    Clin Genet 61:248-56. 2002
  9. ncbi Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate
    Theresa M Zucchero
    University of Iowa, Iowa City 52242, USA
    N Engl J Med 351:769-80. 2004
  10. ncbi Humanitarian missions in the third world: a polite dissent
    Christian C Dupuis
    Plast Reconstr Surg 113:433-5. 2004

Research Grants

  1. Eph/ephrin signaling in craniofacial development and disease
    JEFFREY OHMANN BUSH; Fiscal Year: 2010
  2. Furlow Palatoplasty with Tensor Tenopexy for Otitis Media
    Joseph E Losee; Fiscal Year: 2011
  3. Quality of Life in Children with Cleft
    Hillary Broder; Fiscal Year: 2009
  4. Quality of Life in Children with Cleft
    Hillary L Broder; Fiscal Year: 2010
  5. Quality of Life in Children with Cleft
    Hillary L Broder; Fiscal Year: 2010
  6. INTERNATIONAL GENETIC EPIDEMIOLOGY OF ORAL CLEFTS
    Terri Beaty; Fiscal Year: 2009
  7. PREVENTION OF X-RAY INDUCED MALFORMATIONS
    MARVIN SODICOFF; Fiscal Year: 1990
  8. Effects of oral clefts on birth outcomes and cleft risks due to maternal smoking
    GEORGE WEHBY; Fiscal Year: 2007
  9. Quality of Life in Children with Cleft
    Hillary L Broder; Fiscal Year: 2011
  10. CLEFT LIP AND PALATE IN LOS ANGELES HISPANICS
    M Spence; Fiscal Year: 1990

Detail Information

Publications292 found, 100 shown here

  1. ncbi The prevalence of caries in children with a cleft lip and/or palate in Southern Vietnam
    Sjobbe Besseling
    Department of Oral and Maxillofacial Surgery, Vrije Universiteit, Amsterdam, The Netherlands
    Cleft Palate Craniofac J 41:629-32. 2004
    ..The aim of this study was to investigate the prevalence of caries in South Vietnamese children with a known oral cleft...
  2. ncbi Cleft lip and palate
    Peter A Mossey
    Department of Dental and Oral Health, University of Dundee, Dental Hospital and School, Dundee, UK
    Lancet 374:1773-85. 2009
    Clefts of the lip and palate are generally divided into two groups, isolated cleft palate and cleft lip with or without cleft palate, representing a heterogeneous group of disorders affecting the lips and oral cavity...
  3. pmc Disruption of an AP-2alpha binding site in an IRF6 enhancer is associated with cleft lip
    Fedik Rahimov
    Department of Pediatrics, University of Iowa, 2182 ML, S Grand Ave, Iowa City, Iowa 52242, USA
    Nat Genet 40:1341-7. 2008
    Previously we have shown that nonsyndromic cleft lip with or without cleft palate (NSCL/P) is strongly associated with SNPs in IRF6 (interferon regulatory factor 6)...
  4. pmc Cleft lip and palate: understanding genetic and environmental influences
    Michael J Dixon
    Faculty of Medical and Human Sciences, Manchester Academic Health Sciences Centre, Michael Smith Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Nat Rev Genet 12:167-78. 2011
    ..These findings have advanced our understanding of developmental biology and created new opportunities for clinical translational research...
  5. ncbi MSX1 and TGFB3 contribute to clefting in South America
    A R Vieira
    Departments of Pediatrics, 2613 JCP, University of Iowa, Iowa City, 52242 1083, USA
    J Dent Res 82:289-92. 2003
    ..With transmission disequilibrium test analysis, cleft lip with/without cleft palate, cleft lip with palate plus cleft palate only, and all datasets combined showed ..
  6. pmc A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4
    Terri H Beaty
    Johns Hopkins University, School of Public Health, Baltimore, Maryland, USA
    Nat Genet 42:525-9. 2010
    Case-parent trios were used in a genome-wide association study of cleft lip with and without cleft palate...
  7. doi Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate
    Elisabeth Mangold
    Institute of Human Genetics, Life and Brain Center, University of Bonn, Bonn, Germany
    Nat Genet 42:24-6. 2010
    We conducted a genome-wide association study for nonsyndromic cleft lip with or without cleft palate (NSCL/P) in 401 affected individuals and 1,323 controls, with replication in an independent sample of 793 NSCL/P triads...
  8. ncbi Gene/environment causes of cleft lip and/or palate
    J C Murray
    Department of Pediatrics, University of Iowa, Iowa City 52242, USA
    Clin Genet 61:248-56. 2002
    Craniofacial anomalies, and in particular cleft lip and palate, are major human birth defects with a worldwide frequency of 1 in 700 and substantial clinical impact...
  9. ncbi Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate
    Theresa M Zucchero
    University of Iowa, Iowa City 52242, USA
    N Engl J Med 351:769-80. 2004
    b>Cleft lip or palate (or the two in combination) is a common birth defect that results from a mixture of genetic and environmental factors...
  10. ncbi Humanitarian missions in the third world: a polite dissent
    Christian C Dupuis
    Plast Reconstr Surg 113:433-5. 2004
  11. doi Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24
    Stefanie Birnbaum
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Nat Genet 41:473-7. 2009
    ..involving 224 cases and 383 controls of Central European origin to identify susceptibility loci for nonsyndromic cleft lip with or without cleft palate (NSCL/P). A 640-kb region at chromosome 8q24...
  12. pmc Association of MSX1 and TGFB3 with nonsyndromic clefting in humans
    A C Lidral
    Department of Orthodontics, Ohio State University, Columbus, USA
    Am J Hum Genet 63:557-68. 1998
    Nonsyndromic cleft lip with or without cleft palate (CL/P) and nonsyndromic cleft palate only (CPO) are common congenital anomalies with significant medical, psychological, social, and economic ramifications...
  13. ncbi p63-associated disorders
    Tuula Rinne
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cell Cycle 6:262-8. 2007
    ..of these features are seen in five different syndromes, of which ectrodactyly, ectodermal dysplasia and cleft lip/palate syndrome (EEC) is the most common one...
  14. ncbi Genetic analysis of candidate loci in non-syndromic cleft lip families from Antioquia-Colombia and Ohio
    Lina M Moreno
    Dows Institute for Dental Research, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Med Genet A 125:135-44. 2004
    Non-syndromic cleft lip with or without cleft palate (CL/P) is a genetically complex birth defect, with a prevalence from 1/500 to 1/1,000 live births...
  15. pmc A cohort study of recurrence patterns among more than 54,000 relatives of oral cleft cases in Denmark: support for the multifactorial threshold model of inheritance
    Dorthe Grosen
    Research Centre for the prevention of Infant Mortality and Congenital Illnesses, Institute of Public Health, University of Southern Denmark, JB Winsløws Vej 9, DK 5000 Odense, Denmark
    J Med Genet 47:162-8. 2010
    ..To determine if the anatomical severity of oral clefting affects familial recurrence in a large population based sample. To provide reliable recurrence risk estimates for oral cleft for first, second, and third degree relatives...
  16. ncbi Variants of developmental genes (TGFA, TGFB3, and MSX1) and their associations with orofacial clefts: a case-parent triad analysis
    Astanand Jugessur
    Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
    Genet Epidemiol 24:230-9. 2003
    ..One hundred seventy-four triads of cleft lip cases (CL+/-P) and 88 triads of cleft palate only cases (CPO) were analyzed...
  17. ncbi Distinct functions for Bmp signaling in lip and palate fusion in mice
    Wei Liu
    Alkek Institute of Biosciences and Technology, Texas A and M System Health Science Center, 2121 Holcombe Boulevard, Houston, TX 77030, USA
    Development 132:1453-61. 2005
    Previous work suggested that cleft lip with or without cleft palate (CL/P) is genetically distinct from isolated cleft secondary palate (CP)...
  18. pmc Orofacial clefting: recent insights into a complex trait
    Astanand Jugessur
    Department of Paediatrics, University of Iowa, Iowa City, IA 52242, USA
    Curr Opin Genet Dev 15:270-8. 2005
    ..Together, these complementary strategies are providing researchers with new clues as to what mechanisms underlie orofacial clefting...
  19. doi IRF6 gene variants in Central European patients with non-syndromic cleft lip with or without cleft palate
    Stefanie Birnbaum
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Eur J Oral Sci 117:766-9. 2009
    Variants in the interferon regulatory factor 6 (IRF6) gene have repeatedly been associated with non-syndromic cleft lip with or without cleft palate (NSCL/P)...
  20. doi A genome-wide association study identifies a locus for nonsyndromic cleft lip with or without cleft palate on 8q24
    Struan F A Grant
    Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    J Pediatr 155:909-13. 2009
    To identify, in a non-hypothesis manner, novel genetic factors associated with nonsyndromic cleft lip with or without cleft palate (NSCL/P).
  21. pmc Folic acid and orofacial clefts: a review of the evidence
    G L Wehby
    Department of Health Management and Policy, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
    Oral Dis 16:11-9. 2010
    ..The role of folic acid in the prevention of neural tube defects is also briefly summarized and discussed as a reference model for orofacial clefts...
  22. pmc Evidence that TGFA influences risk to cleft lip with/without cleft palate through unconventional genetic mechanisms
    Jae Woong Sull
    Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea
    Hum Genet 126:385-94. 2009
    ..examined the association between markers in transforming growth factor alpha (TGFA) and isolated, non-syndromic cleft lip with/without palate (CL/P) using a case-parent trio design, considering parent-of-origin effects...
  23. pmc Risk of oral clefts in twins
    Dorthe Grosen
    Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Epidemiology 22:313-9. 2011
    ..Small studies have indicated that twinning increases the risk of oral cleft...
  24. pmc Maternal MTHFR genotype contributes to the risk of non-syndromic cleft lip and palate
    N J Prescott
    J Med Genet 39:368-9. 2002
  25. doi Birth prevalence of cleft lip and palate in Northern Ireland (1981 to 2000)
    T A Gregg
    Royal Belfast Hospital for Sick Children, 180 Falls Road, Belfast, Ireland
    Cleft Palate Craniofac J 45:141-7. 2008
    The prevalence of cleft lip and/or palate (CL/P) in Northern Ireland (NI) was last reported for 1980 through 1990...
  26. ncbi Targeted scan of fifteen regions for nonsyndromic cleft lip and palate in Filipino families
    R E Schultz
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Med Genet A 125:17-22. 2004
    b>Cleft lip with or without cleft palate (CL/P) is a congenital anomaly with variable birth prevalence based on geographic origins, with the highest rates commonly found in Asian populations...
  27. ncbi Epidemiological studies on the frequency of clefts in Europe and world-wide
    Karsten K H Gundlach
    Rostock Interdisciplinary Center for Clefts of Lip, Alveolus and Palate and Craniofacial Anomalies, Rostock, University, Germany
    J Craniomaxillofac Surg 34:1-2. 2006
    ..Most textbooks present data on the various frequencies of clefts in different human "races". This was studied in more detail...
  28. pmc The impact of orofacial clefts on quality of life and healthcare use and costs
    G L Wehby
    Department of Health Management and Policy, College of Public Health, University of Iowa, Iowa City, IA, USA
    Oral Dis 16:3-10. 2010
    ..A summary of the primary limitations of the studies in this area is presented, along with recommendations and directions for future research...
  29. pmc Progress toward discerning the genetics of cleft lip
    Andrew C Lidral
    Department of Orthodontics, University of Iowa, Iowa City, Iowa 52242, USA
    Curr Opin Pediatr 17:731-9. 2005
    ..orofacial clefts are nonsyndromic, isolated defects, which can be separated into two different phenotypes: (1) cleft lip with or without cleft palate and (2) cleft palate only...
  30. ncbi Associations of folate and choline metabolism gene polymorphisms with orofacial clefts
    Adrianna Mostowska
    Department of Biochemistry and Molecular Biology, University of Medical Sciences, Poznan, Poland
    J Med Genet 47:809-15. 2010
    Non-syndromic isolated cleft lip with or without cleft palate (NCL/P) is a common congenital anomaly in humans, the aetiology of which is complex and associated with both genetic and environmental factors...
  31. pmc Genetic determinants of facial clefting: analysis of 357 candidate genes using two national cleft studies from Scandinavia
    Astanand Jugessur
    Craniofacial Development, Musculoskeletal Disorders, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Australia
    PLoS ONE 4:e5385. 2009
    ....
  32. pmc Significant association between IRF6 820G->A and non-syndromic cleft lip with or without cleft palate in the Thai population
    C Srichomthong
    Division of Medical Genetics and Metabolism, Department of Paediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    J Med Genet 42:e46. 2005
    Previous data have shown an association between DNA sequence variants in the IRF6 gene and an increased risk of non-syndromic cleft lip with or without cleft palate (CL/P) in some populations.
  33. ncbi PAX9 and TGFB3 are linked to susceptibility to nonsyndromic cleft lip with or without cleft palate in the Japanese: population-based and family-based candidate gene analyses
    Eisaburo Ichikawa
    Department of Oral and Maxillofacial Surgery, Tokyo Dental College, Chiba, Japan
    J Hum Genet 51:38-46. 2006
    The prevalence of nonsyndromic cleft lip with or without cleft palate (CL/P) and cleft palate only (CPO) are believed to be higher in the Japanese than in Americans, Europeans or Africans...
  34. pmc Multiplex relative risk and estimation of the number of loci underlying an inherited disease
    Paul Schliekelman
    Department of Integrative Biology, University of California, Berkeley, USA
    Am J Hum Genet 71:1369-85. 2002
    ..point by showing that the maximum-likelihood estimate for L produced by the method of Farrall and Holder for cleft lip/cleft palate data is not consistent with the prevalence under the multiplicative model...
  35. ncbi First trimester exposure to corticosteroids and oral clefts
    Pierre Pradat
    Institut Europeen des Genomutations, Lyon, France
    Birth Defects Res A Clin Mol Teratol 67:968-70. 2003
    ..The aim of this study was to test this association by a case-control analysis using the large multicentric MADRE database...
  36. ncbi Quality of life in adults with repaired complete cleft lip and palate
    A Marcusson
    Department of Dentofacial Orthopedics, University Hospital, SE 581 85 Linkoping, Sweden
    Cleft Palate Craniofac J 38:379-85. 2001
    This study evaluated the quality of life in adult Swedish subjects with repaired complete cleft lip and palate (CLP).
  37. doi Cleft lip and palate in family members of cancer survivors
    E Taioli
    Department of Epidemiology, SUNY Downstate Medical Center, Brooklyn, New York, USA
    Cancer Invest 28:958-62. 2010
    The presence of cleft lip with or without cleft palate (CL/P) in family members of cancer patients was investigated...
  38. ncbi Soft tissue profile changes of the midface in patients with cleft lip and palate following maxillary distraction osteogenesis: a preliminary study
    Kiyoshi Harada
    Branch of Oral Surgery, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, Yushima, Japan
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94:673-7. 2002
    ..The purpose of this study was to examine preoperative to postoperative changes of soft tissue profiles in the midface of cleft patients who underwent maxillary distraction...
  39. ncbi Parent-of-origin effects for MSX1 in a Chilean population with nonsyndromic cleft lip/palate
    José Suazo
    Programa de Genética Humana, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Am J Med Genet A 152:2011-6. 2010
    ..postulated muscle segment homeobox 1 (MSX1) as a strong candidate gene involved in the causation of nonsyndromic cleft lip with or without cleft palate (NSCLP)...
  40. doi Global oral health inequalities: challenges in the prevention and management of orofacial clefts and potential solutions
    P A Mossey
    University of Dundee Dental Hospital and School, Scotland, UK
    Adv Dent Res 23:247-58. 2011
    ..The future research agenda also requires engagement with implementation science to get research findings into practice...
  41. ncbi Infant orthopedics and facial growth in complete unilateral cleft lip and palate until six years of age (Dutchcleft)
    Catharina A M Bongaarts
    Department of Orthodontics and Oral Biology, Radbound University Nijmegen Medical Center, The Netherlands
    Cleft Palate Craniofac J 46:654-63. 2009
    To evaluate longitudinally the effect of infant orthopedics (IO) on dentofacial cephalometric variables in unilateral cleft lip and palate (UCLP) patients from 4 to 6 years of age.
  42. ncbi Early craniofacial morphology and growth in children with bilateral complete cleft lip and palate
    N V Hermann
    Department of Pediatric Dentistry and Clinical Genetics, School of Dentistry, Copenhagen University Hospital, Denmark
    Cleft Palate Craniofac J 41:424-38. 2004
    Analysis of craniofacial morphology and growth in children with bilateral complete cleft lip and palate (BCCLP), compared with a control group with unilateral incomplete cleft lip (UICL), before any treatment as well as 20 months after ..
  43. doi SUMO1 polymorphisms are associated with non-syndromic cleft lip with or without cleft palate
    Tao Song
    Department of Oral Maxillofacial Surgery, School of Stomatology, Harbin Medical University, Harbin, China
    Biochem Biophys Res Commun 377:1265-8. 2008
    Small ubiquitin-like modifier 1 (SUMO1) haploinsufficiency results in cleft lip and palate in animal models. However, no studies have linked SUMO1 to non-syndromic cleft lip with or without cleft palate (NSCLP) in humans...
  44. pmc Cancer risk in persons with oral cleft--a population-based study of 8,093 cases
    Camilla Bille
    Center for the Prevention of Congenital Malformations, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Am J Epidemiol 161:1047-55. 2005
    ..revealed only a few significant associations: an increased occurrence of breast cancer among females born with cleft lip and/or cleft palate (standardized incidence ratio (SIR) = 1.52, 95% CI: 1.05, 2...
  45. ncbi The multidisciplinary evaluation and management of cleft lip and palate
    Nathaniel H Robin
    Department of Genetics, University of Alabama at Birmingham, Birmingham AL 35294, USA
    South Med J 99:1111-20. 2006
    b>Cleft lip with or without a cleft palate (CLP) and cleft palate alone (CPA) are common birth defects, with a combined birth prevalence of about 1 to 2/1,000...
  46. ncbi IRF6 is a risk factor for nonsyndromic cleft lip in the Brazilian population
    Luciano A Brito
    Human Genome Research Center, Department of Genetics, Institute de Biosciences, University of Sao Paulo, Sao Paulo, Brazil
    Am J Med Genet A 158:2170-5. 2012
    Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a complex disorder with a worldwide incidence estimated at 1:700. Among the putative susceptibility loci, the IRF6 gene and a region at 8q24...
  47. pmc Differential parental transmission of markers in RUNX2 among cleft case-parent trios from four populations
    Jae Woong Sull
    Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Genet Epidemiol 32:505-12. 2008
    Isolated cleft lip with or without cleft palate (CL/P) is among the most common human birth defects, with a prevalence around 1 in 700 live births...
  48. doi Distraction osteogenesis in the management of severe maxillary hypoplasia in cleft lip and palate patients
    Paolo Scolozzi
    Division of Oral and Maxillofacial Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Geneva, Switzerland
    J Craniofac Surg 19:1199-214. 2008
    ..We used cleft lip and palate and distraction osteogenesis as key words...
  49. doi Rectangular mucosal flap with artificial dermis grafting for vermilion deformity in cleft lips
    S Wakami
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Osaka City University, Asahi 1 4 3, Abeno, Osaka 545 8585, Japan
    J Plast Reconstr Aesthet Surg 63:22-7. 2010
    The treatment of whistling deformity in patients with cleft lip remains controversial. Previous reconstruction methods of whistling deformity have been limited in volume due to the necessity for primary closure of the donor site...
  50. doi Cleft lip with cleft palate, ankyloglossia, and hypodontia are associated with TBX22 mutations
    P N Kantaputra
    Department of Orthodontics and Paediatric Dentistry, and Craniofacial Genetics Laboratory, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand
    J Dent Res 90:450-5. 2011
    ..Several individuals in these families were also found to have micro/hypodontia. This study has expanded the phenotypic spectrum of TBX22-related mutations to include dental anomalies and cleft lip.
  51. doi MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate
    Triin Jagomagi
    Department of Stomatology, Faculty of Medicine, University of Tartu, Tartu, Estonia
    Eur J Oral Sci 118:213-20. 2010
    ..The most significant associations with nonsyndromic cleft lip with or without cleft palate (CL/P) were found for SNPs in MSX1, MTHFR, and PVRL2, including several common ..
  52. doi Association between genetic variants of reported candidate genes or regions and risk of cleft lip with or without cleft palate in the polish population
    Adrianna Mostowska
    Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poland
    Birth Defects Res A Clin Mol Teratol 88:538-45. 2010
    b>Cleft lip with or without cleft palate (CL/P) is one of the most common craniofacial malformations, with a complex and multifactorial etiology...
  53. ncbi Dentocraniofacial morphology in parents of children with cleft lip and/or palate
    A Suzuki
    Department of Orthodontics, Faculty of Dentistry, Kyushu University, Fukuoka, Japan
    Cleft Palate Craniofac J 36:131-8. 1999
    The purpose of this study was to compare the dentocraniofacial morphology of parents of children with cleft lip and/or palate (CL/P) with that of parents of children without CL/P and to use the results for genetic counseling.
  54. ncbi TP63 gene mutations in Chinese P63 syndrome patients
    W Yin
    Key Laboratory for Oral Biomedical Engineering of the Ministry of Education, Hospital and School of Stomatology, Wuhan University, Luoyu Road 237, Wuhan 430079, P R China
    J Dent Res 89:813-7. 2010
    ..gene for these phenotypes in Chinese, we recruited two Chinese Ectrodactyly-Ectodermal-dysplasia-Cleft lip/palate syndrome (EEC) cases and a Limb-Mammary-Syndrome (LMS) patient to carry out TP63 gene sequencing...
  55. pmc Cleft lip and palate incidence among the live births in the Republic of Korea
    Sukwha Kim
    Department of Reconstructive Plastic Surgery, College of Medicine, Seoul National University, Seoul, Korea
    J Korean Med Sci 17:49-52. 2002
    We present an epidemiologic study of cleft lip and palate in the Republic of Korea from January 1, 1993 through December 31, 1993. In 1993, the number of total live births was 715,817...
  56. ncbi Transforming growth factor-alpha (TGFA): genomic structure, boundary sequences, and mutation analysis in nonsyndromic cleft lip/palate and cleft palate only
    J Machida
    Department of Pediatrics, University of Iowa, Iowa City, Iowa, 52242, USA
    Genomics 61:237-42. 1999
    Transforming growth factor-alpha (TGFA) has been proposed as a candidate gene in the etiology of nonsyndromic cleft lip with or without cleft palate (NS-CL/P) and of nonsyndromic cleft palate only (NS-CPO)...
  57. ncbi Prevalence of nonsyndromic oral clefts in Texas: 1995-1999
    Syed Shahrukh Hashmi
    University of Texas Health Sciences Center, Houston School of Public Health, Houston, Texas, USA
    Am J Med Genet A 134:368-72. 2005
    Nonsyndromic cleft lip with/without cleft palate (NSCLP) and nonsyndromic cleft palate only (NSCPO) are common complex birth defects affecting 4,000 newborns annually...
  58. ncbi Lip height and lip width after extended Mohler unilateral cleft lip repair
    Court B Cutting
    Institute of Reconstructive Plastic Surgery, New York University Medical Center, New York, NY 10016, USA
    Plast Reconstr Surg 111:17-23; discussion 24-6. 2003
    ..purpose of this study was to evaluate the symmetry in lip height and lip width after extended Mohler unilateral cleft lip repair, with long-term follow-up monitoring...
  59. doi Contribution of MSX1 variants to the risk of non-syndromic cleft lip and palate in a Malay population
    Iman Salahshourifar
    Human Genome Center, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
    J Hum Genet 56:755-8. 2011
    ..Furthermore, the G110G variant displayed a significant association between patients with non-syndromic cleft lip, with or without cleft palate, and normal controls (P=0.001, odds ratio=2.241, 95% confidence interval, 1.357-3...
  60. pmc The effect of cleft lip on adults' responses to faces: cross-species findings
    Christine E Parsons
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom
    PLoS ONE 6:e25897. 2011
    b>Cleft lip and palate is the most common of the congenital conditions affecting the face and cranial bones and is associated with a raised risk of difficulties in infant-caregiver interaction; the reasons for such difficulties are not ..
  61. ncbi Parental craniofacial morphology in cleft lip with or without cleft palate as determined by cephalometry: a meta-analysis
    S M Weinberg
    Center for Craniofacial and Dental Genetics, Division of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Orthod Craniofac Res 9:18-30. 2006
    To integrate findings from previous cephalometric studies comparing the craniofacial complex of unaffected parents with cleft lip with or without cleft palate (CL/P) children to controls with no history of the disease.
  62. ncbi Coping strategies and social support in the family impact of cleft lip and palate and parents' adjustment and psychological distress
    Sarah R Baker
    Department of Oral Health and Development, School of Clinical Dentistry, University of Sheffield, UK
    Cleft Palate Craniofac J 46:229-36. 2009
    To examine the role of parents' coping strategies and social support in the family impact of cleft lip and palate (CLP) and levels of adjustment and psychological distress and to investigate whether a child's age, type of cleft, or other ..
  63. doi Potential economic benefit of cleft lip and palate repair in sub-Saharan Africa
    Blake Alkire
    Department of Plastic and Oral Surgery, Children s Hospital Boston, and Department of Global Health and Social Medicine, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    World J Surg 35:1194-201. 2011
    ..The present study aimed to establish a methodology for valuing the potential economic benefit of surgical intervention using cleft lip and palate (CLP) in sub-Saharan Africa (SSA) as a model.
  64. ncbi Two novel TP63 mutations associated with the ankyloblepharon, ectodermal defects, and cleft lip and palate syndrome: a skin fragility phenotype
    Aimee S Payne
    Department of Dermatology, University of Pennsylvania, 220 Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Arch Dermatol 141:1567-73. 2005
    Ankyloblepharon, ectodermal defects, and cleft lip and palate (AEC) syndrome is a rare autosomal dominant disorder caused by mutations in the sterile alpha motif region of TP63, a homologue of the tumor suppressor TP53...
  65. ncbi Epidemiology of cleft lip and cleft palate in Pakistan
    Mohammed Mehboob Elahi
    Division of Plastic and Reconstructive Surgery, Temple University, 1600 Arch Street, Suite 508, Philadelphia, PA 19103, USA
    Plast Reconstr Surg 113:1548-55. 2004
    ..serve as a means of establishing data important for the diagnosis, treatment, and counseling of patients with cleft lip and cleft palate...
  66. ncbi Unraveling human cleft lip and palate research
    A R Vieira
    Departments of Oral Biology and Pediatric Dentistry, School of Dental Medicine, University of Pittsburgh, PA 15261, USA
    J Dent Res 87:119-25. 2008
    The focus of this work is to highlight the most recent advances in the understanding of cleft lip and palate occurrence...
  67. doi Secondary alveolar bone grafting: the dilemma of donor site selection and morbidity
    Ma amon A Rawashdeh
    Department Oral and Maxillofacial Surgery, Jordan University of Science and Technology, Jordan
    Br J Oral Maxillofac Surg 46:665-70. 2008
    ..Much more research and development are necessary to find a suitable carrier for rhBMP-2, and to study the properties of newly formed bone that it has induced before it can be a substitute for autogenous bone...
  68. pmc Expression analyses of human cleft palate tissue suggest a role for osteopontin and immune related factors in palatal development
    Linda P Jakobsen
    Wilhelm Johannsen Centre for Functional Genome Research, Department of Cellular and Molecular Medicine, Panum Institute, Copenhagen, Denmark
    Exp Mol Med 41:77-85. 2009
    b>Cleft lip and/or palate (CL/P) is a common congenital malformation with a complex etiology which is not fully elucidated yet...
  69. doi Risk factors for oral clefts: a population-based case-control study in Shenyang, China
    Wei Wang
    Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China
    Paediatr Perinat Epidemiol 23:310-20. 2009
    ..76 per 1000. The ratio of cleft lip with or without cleft palate (CL +/- P) : cleft palate only (CP) was 5.60:1...
  70. doi PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase
    Christoph Loenarz
    Oxford Centre for Integrative Systems Biology, University of Oxford, Oxford, UK
    Hum Mol Genet 19:217-22. 2010
    Mutations of human PHF8 cluster within its JmjC encoding exons and are linked to mental retardation (MR) and a cleft lip/palate phenotype...
  71. pmc Mutations in BMP4 are associated with subepithelial, microform, and overt cleft lip
    Satoshi Suzuki
    Division of Research and Treatment for Oral and Maxillofacial Congenital Anomalies, School of Dentistry, Aichi Gakuin University, Chikusa ku, Nagoya, Japan
    Am J Hum Genet 84:406-11. 2009
    b>Cleft lip with or without cleft palate (CL/P) is a complex trait with evidence that the clinical spectrum includes both microform and subepithelial lip defects...
  72. pmc Ozone and other air pollutants and the risk of oral clefts
    Bing Fang Hwang
    Department of Occupational Safety and Health, College of Public Health, China Medical University, Taichung, Taiwan
    Environ Health Perspect 116:1411-5. 2008
    ..Air pollution influences the development of oral clefts in animals. There are few epidemiologic data on the relation of prenatal air pollution exposure and the risk of oral clefts...
  73. pmc FOXE1 association with both isolated cleft lip with or without cleft palate, and isolated cleft palate
    Lina M Moreno
    Department of Orthodontics, College of Dentistry, University of Iowa, Iowa City, IA 52242, USA
    Hum Mol Genet 18:4879-96. 2009
    ..A previous genome-wide linkage scan discovered a novel locus for cleft lip with or without cleft palate (CL/P) at 9q22-q33...
  74. ncbi Regional anesthesia for cleft lip repair: a preliminary study
    Naveen Eipe
    Department of Anesthesia, Padhar Hospital, Padhar, Betul District, Madhya Pradesh 460005, India
    Cleft Palate Craniofac J 43:138-41. 2006
    To assess whether local anesthetic blockade of the infraorbital nerve may allow for cleft lip repair to be performed under regional anesthesia.
  75. ncbi Cleft deformities in Zimbabwe, Africa: socioeconomic factors, epidemiology, and surgical reconstruction
    Annette M Pham
    Cleft and Craniofacial Program, Facial Plastic and Reconstructive Surgery, Department of Otolaryngology Head and Neck Surgery, University of California, Davis School of Medicine, 2521 Stockton Blvd, Sacramento, CA 95817, USA
    Arch Facial Plast Surg 9:385-91. 2007
    ..Although cleft lip and palate has a lower incidence in Africa (0...
  76. ncbi Evaluation of oral and nasal halitosis parameters in patients with repaired cleft lip and/or palate
    Flávio Monteiro-Amado
    Hospital for Rehabilitation of Craniofacial Anomalies, Universidade of São Paulo, and Master of Science in Stomatology by Bauru Dental School, Universidade of São Paulo, Bauru, Brazil
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100:682-7. 2005
    The objective of this study was to investigate the relationship between halitosis parameters in patients with and without cleft lip and/or palate.
  77. ncbi Botulinum toxin to improve results in cleft lip repair
    Travis T Tollefson
    Department of Otolaryngology Head and Neck Surgery, University of California, Davis Medical Center, Sacramento 95817, USA
    Arch Facial Plast Surg 8:221-2. 2006
  78. ncbi Dental caries prevalence in children with cleft lip/palate aged between 6 months and 6 years in the West of Scotland
    K F M Britton
    Department of Paediatric Dentistry, Glasgow Dental Hospital and School, 378 Sauchiehall Street, Glasgow, Scotland, G2 3JZ
    Eur Arch Paediatr Dent 11:236-41. 2010
    To compare the prevalence of dental caries in children with cleft lip/palate with national data at the same age.
  79. doi Dental and oral hygiene status in Jordanian children with cleft lip and palate: a comparison between unilateral and bilateral clefts
    A M Hazza'a
    Department of Oral Medicine and Oral Surgery, Jordan University of Science and Technology, Irbid, Jordan
    Int J Dent Hyg 9:30-6. 2011
    The purpose of this study was to assess and compare the dental health and oral hygiene status of subjects with unilateral and bilateral cleft lip and palate (BCLP).
  80. ncbi Congenital missing permanent teeth in Korean unilateral cleft lip and alveolus and unilateral cleft lip and palate patients
    Seung Hak Baek
    School of Dentistry, Dental Research Institute, Seoul National University, Department of Orthodontics, Seoul, South Korea
    Angle Orthod 77:88-93. 2007
    ..maxillary lateral incisor [MLI] and maxillary second premolar [MSP]) and sidedness (cleft vs noncleft) between boys and girls in Korean unilateral cleft lip and alveolus (UCLA) and unilateral cleft lip and palate (UCLP) patients.
  81. ncbi Wnt9b is the mutated gene involved in multifactorial nonsyndromic cleft lip with or without cleft palate in A/WySn mice, as confirmed by a genetic complementation test
    Diana M Juriloff
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    Birth Defects Res A Clin Mol Teratol 76:574-9. 2006
    Nonsyndromic cleft lip (CL) with or without cleft palate (CLP) is a common human birth defect with complex genetic etiology. One of the unidentified genes maps to chromosome 17q21...
  82. ncbi Cleft lip and palate in southwestern Iran: an epidemiologic study of live births
    Mohammad Hossain Rajabian
    Shiraz University of Medical Sciences, Department of Plastic Surgery, Shiraz, Iran
    Ann Saudi Med 25:385-8. 2005
    b>Cleft lip with or without cleft palate (CL/P), is the most common congenital anomaly in the head and neck worldwide. We studied the prevalence of cleft lip (CL) and palate (CP) in Shiraz, which is located in southwestern Iran.
  83. ncbi A longitudinal study on influence of primary facial deformities on maxillofacial growth in patients with cleft lip and palate
    Norifumi Nakamura
    Division of Maxillofacial Diagnostic and Surgical Sciences, Graduate School of Dental Science, Kyushu University, Maidashi, Fukuoka, Japan
    Cleft Palate Craniofac J 42:633-40. 2005
    ..use three-dimensional (3D) analysis to characterize the primary facial deformities in children with unilateral cleft lip and palate (UCLP) and then serially analyze the relationships between facial deformities and maxillofacial ..
  84. doi Susceptibility locus for non-syndromic cleft lip with or without cleft palate on chromosome 10q25 confers risk in Estonian patients
    Tiit Nikopensius
    Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
    Eur J Oral Sci 118:317-9. 2010
    Non-syndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common birth defects and has a multifactorial etiology that includes both genetic and environmental factors...
  85. ncbi MMP gene polymorphisms as contributors for cleft lip/palate: association with MMP3 but not MMP1
    Ariadne Letra
    Department of Biological Sciences, Bauru Dental School, University of Sao Paulo, Brazil
    Arch Oral Biol 52:954-60. 2007
    ..MMPs can be considered a group of candidate proteins for the etiology of cleft lip with or without cleft palate (CL/P) due to their role in craniofacial modelling...
  86. ncbi Human genetic factors in nonsyndromic cleft lip and palate: an update
    Francesco Carinci
    Department of D M C C C, Section of Maxillofacial Surgery, University of Ferrara, Corso, Giovecca 203, 44100 Ferrara, Italy
    Int J Pediatr Otorhinolaryngol 71:1509-19. 2007
    Nonsyndromic cleft lip and/or palate (or orofacial cleft, OFC) is a malformation characterized by an incomplete separation between nasal and oral cavities without any associated anomalies...
  87. pmc Folate-related gene polymorphisms as risk factors for cleft lip and cleft palate
    James L Mills
    Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Birth Defects Res A Clin Mol Teratol 82:636-43. 2008
    b>Cleft lip with or without cleft palate (CLP) and cleft palate only (CPO) have an inherited component and, many studies suggest, a relationship with folate...
  88. ncbi Craniofacial computerized tomography analysis of the midface of patients with repaired complete unilateral cleft lip and palate
    Sunjay Suri
    Discipline of Orthodontics, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
    Am J Orthod Dentofacial Orthop 134:418-29. 2008
    ..the maxillary dentoalveolar and deeper structures in patients with surgically repaired complete unilateral cleft lip and palate (CLP) and to investigate whether significant asymmetry existed in the deeper midfacial structures, ..
  89. doi Preferential associations between oral clefts and other major congenital anomalies
    Monica Rittler
    ECLAMC Latin American Collaborative Study of Congenital Malformations at Hospital Materno Infantil Ramón Sardá, Buenos Aires, Argentina
    Cleft Palate Craniofac J 45:525-32. 2008
    To identify preferential associations between oral clefts (CL = cleft lip only, CLP = cleft lip with cleft palate, CP = cleft palate) and nonoral cleft anomalies, to interpret them on clinical grounds, and, based on the patterns of ..
  90. doi Factors influencing early childhood caries of cleft lip and/or palate children aged 18 to 36 months in southern Thailand
    Teerapong Mutarai
    Orthodontic Division, Department of Preventive Dentistry, Prince of Songkhla University, Thailand
    Cleft Palate Craniofac J 45:468-72. 2008
    ..To clarify whether oral health care behavior or oral cleft status influences early childhood caries in southern Thailand cleft children...
  91. ncbi Oral and nasal malodor in patients with and without cleft lip and palate who had undergone orthodontic therapy
    Cenk Doruk
    Department of Orthodontics, University of Cumhuriyet, Sivas, Turkey
    Cleft Palate Craniofac J 45:481-4. 2008
    To compare oral and nasal malodor in patients with and without cleft lip and palate (CLP) who had undergone orthodontic therapy.
  92. ncbi Pattern of cleft lip and palate in hospital-based population in Saudi Arabia: retrospective study
    Aziza Aljohar
    Dentistry Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Cleft Palate Craniofac J 45:592-6. 2008
    To report the patterns of cleft lip and/or cleft palate in Saudi Arabia from data collected at a tertiary care hospital.
  93. ncbi Cleft lip and/or palate: 10 years experience at a pediatric cleft center in Southern Thailand
    Somchit Jaruratanasirikul
    Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand
    Cleft Palate Craniofac J 45:597-602. 2008
    To study the clinical characteristics, demographic data, and associated congenital anomalies of pediatric patients with cleft lip and/or palate in Southern Thailand.
  94. pmc Time trends in oral clefts in Chinese newborns: data from the Chinese National Birth Defects Monitoring Network
    Li Dai
    National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Chengdu, 610041, China
    Birth Defects Res A Clin Mol Teratol 88:41-7. 2010
    ..Although the prevalence of oral clefts in China is among the highest in countries worldwide, little is known about its descriptive epidemiology...
  95. ncbi Facial cleft and associated anomalies: incidence among infants at a Jordanian medical centre
    H E Aqrabawi
    Neonatal Unit, King Hussein Medical Centre, Amman, Jordan
    East Mediterr Health J 14:356-9. 2008
    To estimate incidence of cleft lip and cleft palate among Jordanian infants and to identify associated anomalies, we carried out a prospective, hospital-based study over a 5-year period, January 2000-January 2005...
  96. ncbi Comparison of dental caries prevalence in patients with cleft lip and/or palate and their sibling controls
    Mahmoud Al-Dajani
    College of Dentistry, International University for Science and Technology, Dara, Syria
    Cleft Palate Craniofac J 46:529-31. 2009
    To evaluate the prevalence of dental caries in patients with cleft lip and/or palate and their cleft-free sibling controls.
  97. doi Cleft lip and palate as a cost-effective health care treatment in the developing world
    William P Magee
    Operation Smile, 6435 Tidewater Drive, Norfolk, Virginia 23509, USA
    World J Surg 34:420-7. 2010
    ..The authors suggest that surgery has an important role in global public health, specifically through international volunteer surgical missions as a vehicle for delivery...
  98. ncbi Epidemiology underpinning research in the aetiology of orofacial clefts
    Peter Mossey
    University of Dundee, Dental Hospital and School, Dundee, Scotland, UK
    Orthod Craniofac Res 10:114-20. 2007
    ....
  99. ncbi Caries prevalence in children with cleft lip and palate--a systematic review of case-control studies
    Pamela Hasslöf
    Department of Odontology, Pediatic Dentistry, Faculty of Medicine, Umea University, Umea, Sweden
    Int J Paediatr Dent 17:313-9. 2007
    To conduct a systematic review of literature in order to examine the evidence of an increased prevalence of dental caries in children with cleft lip and palate (CLP).
  100. ncbi Outcome of secondary alveolar bone grafting before and after eruption of the canine in Jordanian patients with cleft lip and palate
    Ma amon A Rawashdeh
    Department of Oral and Maxillofacial Surgery, Jordan University of Science and Technology and King Abdullah University Hospital, Cleft Lip and Palate Centre, Irbid, Jordan
    J Craniofac Surg 18:1331-7. 2007
    This prospective study was carried out at the Cleft Lip and Palate Centre at King Abdullah University Hospital and Maxillofacial Unit at Jordan University of Science and Technology during the period of 2000 to 2006...
  101. ncbi Tissue engineering solutions for cleft palates
    Jennifer L Moreau
    Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, MD, USA
    J Oral Maxillofac Surg 65:2503-11. 2007
    ..Clefts of the lip and palate are the most prevalent congenital craniofacial birth defect in humans. The developing field of tissue engineering is considered for the management of clefts of the lip and palate...

Research Grants85

  1. Eph/ephrin signaling in craniofacial development and disease
    JEFFREY OHMANN BUSH; Fiscal Year: 2010
    ..Bush is a postdoctoral fellow who received his Ph.D. at the University of Rochester for work in understanding cleft lip and palate in the spontaneously-occurring Dancer mutant mouse...
  2. Furlow Palatoplasty with Tensor Tenopexy for Otitis Media
    Joseph E Losee; Fiscal Year: 2011
    ..The surgical procedures will include cleft lip repair (if present) at 3-6 months of age, bilateral placement of a ventilation tube (VT) at 3-6 months of age, ..
  3. Quality of Life in Children with Cleft
    Hillary Broder; Fiscal Year: 2009
    ..This project will enroll children (ages 8-17) with cleft palate only (CPO) and cleft lip and palate and their caregivers who are evaluated at five renown craniofacial centers (two in the southeast and ..
  4. Quality of Life in Children with Cleft
    Hillary L Broder; Fiscal Year: 2010
    ..This project will enroll children (ages 8-17) with cleft palate only (CPO) and cleft lip and palate and their caregivers who are evaluated at five renown craniofacial centers (two in the southeast and ..
  5. Quality of Life in Children with Cleft
    Hillary L Broder; Fiscal Year: 2010
    ..This project will enroll children (ages 8-17) with cleft palate only (CPO) and cleft lip and palate and their caregivers who are evaluated at five renown craniofacial centers (two in the southeast and ..
  6. INTERNATIONAL GENETIC EPIDEMIOLOGY OF ORAL CLEFTS
    Terri Beaty; Fiscal Year: 2009
    ..we successfully conducted a multi-center, international study on the genetic etiology of oral clefts (including cleft lip, CL;cleft lip and palate, CLP;and cleft palate, CP) by recruiting cases from 5 sites (Maryland, Singapore, ..
  7. PREVENTION OF X-RAY INDUCED MALFORMATIONS
    MARVIN SODICOFF; Fiscal Year: 1990
    ..g., shape, shortening of the mandible and maxilla, cleft lip, palate, and face with defects of eye and ear development. Gross malformations of the CNS e.g...
  8. Effects of oral clefts on birth outcomes and cleft risks due to maternal smoking
    GEORGE WEHBY; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Cleft lip and/or palate (CL/P) is a common birth defect with a complex ideology and large health burden...
  9. Quality of Life in Children with Cleft
    Hillary L Broder; Fiscal Year: 2011
    ..This project will enroll children (ages 8-17) with cleft palate only (CPO) and cleft lip and palate and their caregivers who are evaluated at five renown craniofacial centers (two in the southeast and ..
  10. CLEFT LIP AND PALATE IN LOS ANGELES HISPANICS
    M Spence; Fiscal Year: 1990
    ..by determining if referral bias or some other irrelevant factor accounts for the increases frequency of cleft lip with cleft palate in our sample. The sex ratio and bilateral vs...
  11. Health outcomes and improved phenotypic characterization of cleft lip and palate
    GEORGE WEHBY; Fiscal Year: 2007
    b>Cleft lip and/or palate (CLP) is a common birth defect occurring in about 1/500 to 1/2500 births...
  12. Health outcomes and improved phenotypic characterization of cleft lip and palate
    GEORGE WEHBY; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Cleft lip and/or palate (CLP) is a common birth defect occurring in about 1/500 to 1/2500 births...
  13. Effects of Dioxin on Vietnamese Civilians
    David Carpenter; Fiscal Year: 2004
    ..These hospitals serve maternity patients from all of southern Vietnam. The investigators will study cases of a) cleft lip/cleft palate, b) neural tube defects, including spina bifida, anecephaly and microcephaly, and c) limb ..
  14. Speech Intelligibility Testing in Children with Repaired Cleft Palate
    David Zajac; Fiscal Year: 2007
    ..underlie speech intelligibility in young children with repaired clefts of the secondary palate with or without cleft lip (Aim 1)...
  15. DGAP: Developmental Genome Anatomy Project
    Cynthia Morton; Fiscal Year: 2009
    ..These anomalies can include isolated defects ranging from cleft lip/palate, abdominal wall defects, limb defects, cardiac abnormalities or mental retardation, or they can occur as ..
  16. Eustachian Tube Form/Function in Cleft Lip and Palate
    Anil Gungor; Fiscal Year: 2003
    ..If these predictions are valid, an early MRI study of CP infants be prognostic of the severity and longevity of ME disease and may serve to guide the type of palatal reconstruction for individual patients. ..
  17. Eustachian Tube Form/Function in Cleft Lip and Palate
    Anil Gungor; Fiscal Year: 2004
    ..If these predictions are valid, an early MRI study of CP infants be prognostic of the severity and longevity of ME disease and may serve to guide the type of palatal reconstruction for individual patients. ..
  18. WOUND HEALING AFTER FETAL CLEFT LIP REPAIR
    Leonard Kaban; Fiscal Year: 1990
    Although excellent esthetic and functional results can be achieved with post-natal cleft lip and palate repair, consecutive surgical procedures lead to scar formation and secondary midface growth retardation...
  19. NASAL AIRWAY AND RESPIRATORY MODE IN CLEFT PALATE
    DONALD WARREN; Fiscal Year: 1990
    The broad long-term objectives of this project are to: 1) determine how cleft lip/palate and its management affect nasal airway patency and breathing behaviors and 2) assess the biological, morphological and behavioral consequences of ..
  20. DNA LINKAGE STUDY OF CLEFT LIP AND PALATE
    Jacqueline Hecht; Fiscal Year: 1991
    The overall aim of this project is to delineate the molecular mechanisms of heritable nonsyndromic cleft lip with or without cleft palate (CLP)...
  21. VELOPHARYNGEAL FUNCTION FOR SPEECH AFTER PALATAL SURGERY
    William Williams; Fiscal Year: 2004
    The incidence of cleft lip/palate is 1/750, making it one of the most common congenital malformations...
  22. VELOPHARYNGEAL FUNCTION FOR SPEECH AFTER PALATAL SURGERY
    William Williams; Fiscal Year: 2002
    The incidence of cleft lip/palate is 1/750, making it one of the most common congenital malformations...
  23. VELOPHARYNGEAL FUNCTION FOR SPEECH AFTER PALATAL SURGERY
    William Williams; Fiscal Year: 2000
    The incidence of cleft lip/palate is 1/750, making it one of the most common congenital malformations...
  24. VELOPHARYNGEAL FUNCTION FOR SPEECH AFTER PALATAL SURGERY
    William Williams; Fiscal Year: 2003
    The incidence of cleft lip/palate is 1/750, making it one of the most common congenital malformations...
  25. VELOPHARYNGEAL FUNCTION FOR SPEECH AFTER PALATAL SURGERY
    William Williams; Fiscal Year: 2001
    The incidence of cleft lip/palate is 1/750, making it one of the most common congenital malformations...
  26. MOLECULAR GENETIC EPIDEMIOLOGY OF CLEFT LIP AND PALATE
    Jeffrey C Murray; Fiscal Year: 2012
    ..We hope we have established an environment in which students can explore paths to careers in dental/craniofacial research. ..
  27. Functional Outcomes of Cleft Lip Surgery
    CARROLL TROTMAN; Fiscal Year: 2003
    DESCRIPTION: (from the abstract) The prevalence of cleft lip and palate in the United States is approximately 1 in 1000 live births (range of 0.7 to 1.3)...
  28. Skin Regeneration: Cellular & Molecular Mechanisms
    HERMANN PETER LORENZ; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cleft lip and palate is a major health problem because of the functional defect produced...
  29. Functional Outcomes of Cleft Lip Surgery
    CARROLL TROTMAN; Fiscal Year: 2001
    DESCRIPTION: (from the abstract) The prevalence of cleft lip and palate in the United States is approximately 1 in 1000 live births (range of 0.7 to 1.3)...
  30. Functional Outcomes of Cleft Lip Surgery
    CARROLL TROTMAN; Fiscal Year: 2004
    DESCRIPTION: (from the abstract) The prevalence of cleft lip and palate in the United States is approximately 1 in 1000 live births (range of 0.7 to 1.3)...
  31. Functional Outcomes of Cleft Lip Surgery
    CARROLL TROTMAN; Fiscal Year: 2002
    DESCRIPTION: (from the abstract) The prevalence of cleft lip and palate in the United States is approximately 1 in 1000 live births (range of 0.7 to 1.3)...
  32. Gene-enviornment interactions in facial clefts
    Kaare Christensen; Fiscal Year: 2006
    ..Family and twin studies have clearly indicated a genetic role in the etiology of cleft lip and palate, but environmental components play a major role, as well...
  33. Gene-enviornment interactions in facial clefts
    Kaare Christensen; Fiscal Year: 2003
    ..Family and twin studies have clearly indicated a genetic role in the etiology of cleft lip and palate, but environmental components play a major role, as well...
  34. Gene-enviornment interactions in facial clefts
    Kaare Christensen; Fiscal Year: 2004
    ..Family and twin studies have clearly indicated a genetic role in the etiology of cleft lip and palate, but environmental components play a major role, as well...
  35. Gene-enviornment interactions in facial clefts
    Kaare Christensen; Fiscal Year: 2005
    ..Family and twin studies have clearly indicated a genetic role in the etiology of cleft lip and palate, but environmental components play a major role, as well...
  36. ORAL-FACIAL CLEFTS IN CHINA
    Michael Melnick; Fiscal Year: 1990
    b>Cleft lip with or without cleft palate (CL+-P) is a major health problem, afflicting 1 in every 500-1000 newborn babies world wide; the etiology remains unclear. For CL+-P, Orientals are at higher risk than Caucasians or Blacks...
  37. Skin Regeneration: Cellular & Molecular Mechanisms
    HERMANN LORENZ; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Cleft lip and palate is a major health problem because of the functional defect produced...
  38. GENE-ENVIRONMENT INTERACTION IN FACIAL CLEFTS
    Kaare Christensen; Fiscal Year: 2000
    ..advances in epidemiologic approaches and reprotoxicology demonstrate that several common disorders such as cleft lip and/or palate (CLP), neural tube defects and congenital heart defects have a significant proportion of their ..
  39. BIRTH DEFECTS TREATMENT AND PREVENTION PROGRAM
    Jeffrey Murray; Fiscal Year: 2005
    DESCRIPTION (Provided by applicant): Cleft lip and cleft palate can serve as a sentinel for birth defects in general for the impact that they have on fetal and maternal health...
  40. BIRTH DEFECTS TREATMENT AND PREVENTION PROGRAM
    Jeffrey Murray; Fiscal Year: 2004
    DESCRIPTION (Provided by applicant): Cleft lip and cleft palate can serve as a sentinel for birth defects in general for the impact that they have on fetal and maternal health...
  41. An Exploratory Model of Early Speech Intervention for Children with Cleft Palate
    Nancy Scherer; Fiscal Year: 2009
    Young children with cleft lip and/or palate are at risk for speech and language delays associated with structural deficits despite early surgical repair...
  42. BIRTH DEFECTS TREATMENT AND PREVENTION PROGRAM
    Jeffrey Murray; Fiscal Year: 2006
    DESCRIPTION (Provided by applicant): Cleft lip and cleft palate can serve as a sentinel for birth defects in general for the impact that they have on fetal and maternal health...
  43. An Exploratory Model of Early Speech Intervention for Children with Cleft Palate
    Nancy J Scherer; Fiscal Year: 2010
    Young children with cleft lip and/or palate are at risk for speech and language delays associated with structural deficits despite early surgical repair...
  44. BIRTH DEFECTS TREATMENT AND PREVENTION PROGRAM
    Jeffrey Murray; Fiscal Year: 2003
    DESCRIPTION (Provided by applicant): Cleft lip and cleft palate can serve as a sentinel for birth defects in general for the impact that they have on fetal and maternal health...
  45. BIRTH DEFECTS TREATMENT AND PREVENTION PROGRAM
    Jeffrey Murray; Fiscal Year: 2002
    DESCRIPTION (Provided by applicant): Cleft lip and cleft palate can serve as a sentinel for birth defects in general for the impact that they have on fetal and maternal health...
  46. GENE-ENVIRONMENT INTERACTION IN FACIAL CLEFTS
    Kaare Christensen; Fiscal Year: 1999
    ..advances in epidemiologic approaches and reprotoxicology demonstrate that several common disorders such as cleft lip and/or palate (CLP), neural tube defects and congenital heart defects have a significant proportion of their ..
  47. BIRTH DEFECTS TREATMENT AND PREVENTION PROGRAM
    Jeffrey Murray; Fiscal Year: 2005
    DESCRIPTION (Provided by applicant): Cleft lip and cleft palate can serve as a sentinel for birth defects in general for the impact that they have on fetal and maternal health...
  48. BIRTH DEFECTS TREATMENT AND PREVENTION PROGRAM
    Jeffrey Murray; Fiscal Year: 2001
    DESCRIPTION (Provided by applicant): Cleft lip and cleft palate can serve as a sentinel for birth defects in general for the impact that they have on fetal and maternal health...
  49. Cleft Lip Genetics: A Multicenter International Consorti
    Andrew Lidral; Fiscal Year: 2001
    b>Cleft lip with or without cleft palate (CL/P) is a common birth defect. Previous studies have indicated that CL/P is a complex trait that is caused by a combination of genetic and environmental factors...
  50. Cleft Lip Genetics: A Multicenter International Consorti
    Andrew Lidral; Fiscal Year: 2004
    b>Cleft lip with or without cleft palate (CL/P) is a common birth defect. Previous studies have indicated that CL/P is a complex trait that is caused by a combination of genetic and environmental factors...
  51. Cleft Lip Genetics: A Multicenter International Consorti
    Andrew Lidral; Fiscal Year: 2002
    b>Cleft lip with or without cleft palate (CL/P) is a common birth defect. Previous studies have indicated that CL/P is a complex trait that is caused by a combination of genetic and environmental factors...
  52. Cleft Lip Genetics: A Multicenter International Consorti
    Andrew Lidral; Fiscal Year: 2003
    b>Cleft lip with or without cleft palate (CL/P) is a common birth defect. Previous studies have indicated that CL/P is a complex trait that is caused by a combination of genetic and environmental factors...
  53. IDENTICAL BY DESCENT MAPPING OF CRANIOFACIAL ANOMALIES
    Andrew Lidral; Fiscal Year: 1999
    ..Most orofacial clefts are non-syndromic, isolated defects, which can be separated into two different phenotypes: cleft lip with or without cleft palate (CL/P) and cleft palate only (CPO)...
  54. CLONING AND CHARACTERIZATION OF THE VAN DER WOUDE GENE
    Brian Schutte; Fiscal Year: 2007
    b>Cleft lip and palate is a common congenital anomaly with significant lifelong morbidity. The extensive psychological, surgical, speech and dental involvement emphasize the importance of understanding the underlying causes...
  55. HOMOZYGOSITY MAPPING OF ORAL-FACIAL CLEFTS IN TURKEY
    Mary Marazita; Fiscal Year: 1999
    Oral-facial clefts, particularly cleft lip with or without cleft palate (CL/P) are a major public health problem, affecting one in every 500-1000 births worldwide...
  56. HOMOZYGOSITY MAPPING OF ORAL-FACIAL CLEFTS IN TURKEY
    Mary Marazita; Fiscal Year: 2000
    Oral-facial clefts, particularly cleft lip with or without cleft palate (CL/P) are a major public health problem, affecting one in every 500-1000 births worldwide...
  57. MOLECULAR GENETIC EPIDEMIOLOGY OF CLEFT LIP AND PALATE
    Jeffrey Murray; Fiscal Year: 1993
    ..funding cycle of this proposal the investigators applied these techniques to a common sentinel birth defect--cleft lip and palate...
  58. FATE OF AVIAN NEURAL CREST-DERIVED NEUROGENIC PRECURSORS
    James Weston; Fiscal Year: 1993
    ..neoplasias, such as gliomas, neuroblastomas, and pheochromocytomas; and (d) congenital defects such as cleft lip/palate, and craniofacial defects associated with heart malformation, such as Pierre Robin syndrome...
  59. FATE OF AVIAN NEURAL CREST-DERIVED NEUROGENIC PRECURSORS
    KATHLEEN MORRISON GRAHAM; Fiscal Year: 1991
    ..neoplasias, such as gliomas, neuroblastomas, and pheochromocytomas; and (d) congenital defects such as cleft lip/palate, and craniofacial defects associated with heart malformation, such as Pierre Robin syndrome...
  60. CPAP THERAPY FOR HYPERNASALITY IN CLEFT PALATE SUBJECTS
    David Kuehn; Fiscal Year: 1992
    ..of continuous positive airway pressure (CPAP) therapy for reduction of hypernasality in nonsyndromic unilateral cleft lip and palate subjects between six and twenty-five years old, and of either sex...
  61. MOLECULAR GENETIC EPIDEMIOLOGY OF CLEFT LIP AND PALATE
    Jeffrey Murray; Fiscal Year: 2003
    ..Finally, using an affected pedigree member approach, we have mapped a locus for non-syndromic cleft lip and palate to 6p23...
  62. Growth Factor Signaling in Mouse Palatogensis
    YiPing Chen; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Non-syndromic cleft lip and cleft palate, one of the major groups of congenital birth defects in human beings...
  63. MOLECULAR GENETIC EPIDEMIOLOGY OF CLEFT LIP AND PALATE
    Jeffrey Murray; Fiscal Year: 2001
    ..Finally, using an affected pedigree member approach, we have mapped a locus for non-syndromic cleft lip and palate to 6p23...
  64. MOLECULAR GENETIC EPIDEMIOLOGY OF CLEFT LIP AND PALATE
    Jeffrey Murray; Fiscal Year: 2002
    ..Finally, using an affected pedigree member approach, we have mapped a locus for non-syndromic cleft lip and palate to 6p23...
  65. MOLECULAR GENETIC EPIDEMIOLOGY OF CLEFT LIP AND PALATE
    Jeffrey Murray; Fiscal Year: 2000
    ..Finally, using an affected pedigree member approach, we have mapped a locus for non-syndromic cleft lip and palate to 6p23...
  66. Growth Factor Signaling in Mouse Palatogensis
    YiPing Chen; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Non-syndromic cleft lip and cleft palate, one of the major groups of congenital birth defects in human beings...
  67. INTERNATIONAL GENETIC EPIDEMIOLOGY OF ORAL CLEFTS
    Terri Beaty; Fiscal Year: 2000
    Oral clefts (including cleft lip, CL; cleft palate, CP; and cleft lip and palate, CLP) represent a complex and heterogeneous group of crainofacial defects that constitute a major public health burden due to their high prevalence...
  68. INTERNATIONAL GENETIC EPIDEMIOLOGY OF ORAL CLEFTS
    Terri Beaty; Fiscal Year: 2001
    Oral clefts (including cleft lip, CL; cleft palate, CP; and cleft lip and palate, CLP) represent a complex and heterogeneous group of crainofacial defects that constitute a major public health burden due to their high prevalence...
  69. GENETIC ETIOLOGY OF NONSYNOMIC CLEFT PALATE
    Andrew Lidral; Fiscal Year: 2000
    b>Cleft lip and cleft palate are common birth defects affecting 1-2/1000 live births. It is apparent that genetic factors contribute significantly to their etiology...
  70. GENETIC ETIOLOGY OF NONSYNOMIC CLEFT PALATE
    Andrew Lidral; Fiscal Year: 2001
    b>Cleft lip and cleft palate are common birth defects affecting 1-2/1000 live births. It is apparent that genetic factors contribute significantly to their etiology...
  71. The Role of IRF6 During Craniofacial Development
    Steven Goudy; Fiscal Year: 2009
    Isolated cleft lip and palate is a common congenital problem with a complex etiology. The objective of this research is to identify the function of genes critical to palatal formation...
  72. GENETIC ETIOLOGY OF NONSYNOMIC CLEFT PALATE
    Andrew Lidral; Fiscal Year: 2000
    b>Cleft lip and cleft palate are common birth defects affecting 1-2/1000 live births. It is apparent that genetic factors contribute significantly to their etiology...
  73. The Brain Morphology of Children with Cleft Lip and/or Palate
    MADELEINE BLAIR CHOLLET; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cleft lip and/or palate (CL/P) is a congenital anomaly that is characterized by improper fusion of the upper lip and/or palate...
  74. The Role of IRF6 During Craniofacial Development
    Steven L Goudy; Fiscal Year: 2010
    Isolated cleft lip and palate is a common congenital problem with a complex etiology. The objective of this research is to identify the function of genes critical to palatal formation...
  75. GENETIC ETIOLOGY OF NONSYNOMIC CLEFT PALATE
    Andrew Lidral; Fiscal Year: 2002
    b>Cleft lip and cleft palate are common birth defects affecting 1-2/1000 live births. It is apparent that genetic factors contribute significantly to their etiology...
  76. GENETIC ETIOLOGY OF NONSYNOMIC CLEFT PALATE
    Andrew Lidral; Fiscal Year: 2002
    b>Cleft lip and cleft palate are common birth defects affecting 1-2/1000 live births. It is apparent that genetic factors contribute significantly to their etiology...
  77. DGAP: Developmental Genome Anatomy Project
    CYNTHIA CASSON MORTON; Fiscal Year: 2010
    ..These anomalies can include isolated defects ranging from cleft lip/palate, abdominal wall defects, limb defects, cardiac abnormalities or mental retardation, or they can occur as ..
  78. Oral cleft prevention program
    Jeffrey C Murray; Fiscal Year: 2010
    ..CLP is the most prevalent birth defect in the United States, with about 6,800 new cases which includes cleft lip and/or palate, isolated and non-isolated born each year...