Genomes and Genes
Summary: Congenital defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences. It is thought to be caused by faulty migration of the mesoderm in the head region.
Publications292 found, 100 shown here
- The prevalence of caries in children with a cleft lip and/or palate in Southern VietnamSjobbe Besseling
Department of Oral and Maxillofacial Surgery, Vrije Universiteit, Amsterdam, The Netherlands
Cleft Palate Craniofac J 41:629-32. 2004..The aim of this study was to investigate the prevalence of caries in South Vietnamese children with a known oral cleft...
- Cleft lip and palatePeter A Mossey
Department of Dental and Oral Health, University of Dundee, Dental Hospital and School, Dundee, UK
Lancet 374:1773-85. 2009Clefts of the lip and palate are generally divided into two groups, isolated cleft palate and cleft lip with or without cleft palate, representing a heterogeneous group of disorders affecting the lips and oral cavity...
- Disruption of an AP-2alpha binding site in an IRF6 enhancer is associated with cleft lipFedik Rahimov
Department of Pediatrics, University of Iowa, 2182 ML, S Grand Ave, Iowa City, Iowa 52242, USA
Nat Genet 40:1341-7. 2008Previously we have shown that nonsyndromic cleft lip with or without cleft palate (NSCL/P) is strongly associated with SNPs in IRF6 (interferon regulatory factor 6)...
- Cleft lip and palate: understanding genetic and environmental influencesMichael J Dixon
Faculty of Medical and Human Sciences, Manchester Academic Health Sciences Centre, Michael Smith Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
Nat Rev Genet 12:167-78. 2011..These findings have advanced our understanding of developmental biology and created new opportunities for clinical translational research...
- MSX1 and TGFB3 contribute to clefting in South AmericaA R Vieira
Departments of Pediatrics, 2613 JCP, University of Iowa, Iowa City, 52242 1083, USA
J Dent Res 82:289-92. 2003..With transmission disequilibrium test analysis, cleft lip with/without cleft palate, cleft lip with palate plus cleft palate only, and all datasets combined showed ..
- A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4Terri H Beaty
Johns Hopkins University, School of Public Health, Baltimore, Maryland, USA
Nat Genet 42:525-9. 2010Case-parent trios were used in a genome-wide association study of cleft lip with and without cleft palate...
- Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palateElisabeth Mangold
Institute of Human Genetics, Life and Brain Center, University of Bonn, Bonn, Germany
Nat Genet 42:24-6. 2010We conducted a genome-wide association study for nonsyndromic cleft lip with or without cleft palate (NSCL/P) in 401 affected individuals and 1,323 controls, with replication in an independent sample of 793 NSCL/P triads...
- Gene/environment causes of cleft lip and/or palateJ C Murray
Department of Pediatrics, University of Iowa, Iowa City 52242, USA
Clin Genet 61:248-56. 2002Craniofacial anomalies, and in particular cleft lip and palate, are major human birth defects with a worldwide frequency of 1 in 700 and substantial clinical impact...
- Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palateTheresa M Zucchero
University of Iowa, Iowa City 52242, USA
N Engl J Med 351:769-80. 2004b>Cleft lip or palate (or the two in combination) is a common birth defect that results from a mixture of genetic and environmental factors...
- Humanitarian missions in the third world: a polite dissentChristian C Dupuis
Plast Reconstr Surg 113:433-5. 2004
- Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24Stefanie Birnbaum
Institute of Human Genetics, University of Bonn, Bonn, Germany
Nat Genet 41:473-7. 2009..involving 224 cases and 383 controls of Central European origin to identify susceptibility loci for nonsyndromic cleft lip with or without cleft palate (NSCL/P). A 640-kb region at chromosome 8q24...
- Association of MSX1 and TGFB3 with nonsyndromic clefting in humansA C Lidral
Department of Orthodontics, Ohio State University, Columbus, USA
Am J Hum Genet 63:557-68. 1998Nonsyndromic cleft lip with or without cleft palate (CL/P) and nonsyndromic cleft palate only (CPO) are common congenital anomalies with significant medical, psychological, social, and economic ramifications...
- p63-associated disordersTuula Rinne
Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Cell Cycle 6:262-8. 2007..of these features are seen in five different syndromes, of which ectrodactyly, ectodermal dysplasia and cleft lip/palate syndrome (EEC) is the most common one...
- Genetic analysis of candidate loci in non-syndromic cleft lip families from Antioquia-Colombia and OhioLina M Moreno
Dows Institute for Dental Research, University of Iowa, Iowa City, Iowa 52242, USA
Am J Med Genet A 125:135-44. 2004Non-syndromic cleft lip with or without cleft palate (CL/P) is a genetically complex birth defect, with a prevalence from 1/500 to 1/1,000 live births...
- A cohort study of recurrence patterns among more than 54,000 relatives of oral cleft cases in Denmark: support for the multifactorial threshold model of inheritanceDorthe Grosen
Research Centre for the prevention of Infant Mortality and Congenital Illnesses, Institute of Public Health, University of Southern Denmark, JB Winsløws Vej 9, DK 5000 Odense, Denmark
J Med Genet 47:162-8. 2010..To determine if the anatomical severity of oral clefting affects familial recurrence in a large population based sample. To provide reliable recurrence risk estimates for oral cleft for first, second, and third degree relatives...
- Variants of developmental genes (TGFA, TGFB3, and MSX1) and their associations with orofacial clefts: a case-parent triad analysisAstanand Jugessur
Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
Genet Epidemiol 24:230-9. 2003..One hundred seventy-four triads of cleft lip cases (CL+/-P) and 88 triads of cleft palate only cases (CPO) were analyzed...
- Distinct functions for Bmp signaling in lip and palate fusion in miceWei Liu
Alkek Institute of Biosciences and Technology, Texas A and M System Health Science Center, 2121 Holcombe Boulevard, Houston, TX 77030, USA
Development 132:1453-61. 2005Previous work suggested that cleft lip with or without cleft palate (CL/P) is genetically distinct from isolated cleft secondary palate (CP)...
- Orofacial clefting: recent insights into a complex traitAstanand Jugessur
Department of Paediatrics, University of Iowa, Iowa City, IA 52242, USA
Curr Opin Genet Dev 15:270-8. 2005..Together, these complementary strategies are providing researchers with new clues as to what mechanisms underlie orofacial clefting...
- IRF6 gene variants in Central European patients with non-syndromic cleft lip with or without cleft palateStefanie Birnbaum
Institute of Human Genetics, University of Bonn, Bonn, Germany
Eur J Oral Sci 117:766-9. 2009Variants in the interferon regulatory factor 6 (IRF6) gene have repeatedly been associated with non-syndromic cleft lip with or without cleft palate (NSCL/P)...
- A genome-wide association study identifies a locus for nonsyndromic cleft lip with or without cleft palate on 8q24Struan F A Grant
Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
J Pediatr 155:909-13. 2009To identify, in a non-hypothesis manner, novel genetic factors associated with nonsyndromic cleft lip with or without cleft palate (NSCL/P).
- Folic acid and orofacial clefts: a review of the evidenceG L Wehby
Department of Health Management and Policy, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
Oral Dis 16:11-9. 2010..The role of folic acid in the prevention of neural tube defects is also briefly summarized and discussed as a reference model for orofacial clefts...
- Evidence that TGFA influences risk to cleft lip with/without cleft palate through unconventional genetic mechanismsJae Woong Sull
Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea
Hum Genet 126:385-94. 2009..examined the association between markers in transforming growth factor alpha (TGFA) and isolated, non-syndromic cleft lip with/without palate (CL/P) using a case-parent trio design, considering parent-of-origin effects...
- Risk of oral clefts in twinsDorthe Grosen
Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Epidemiology 22:313-9. 2011..Small studies have indicated that twinning increases the risk of oral cleft...
- Maternal MTHFR genotype contributes to the risk of non-syndromic cleft lip and palateN J Prescott
J Med Genet 39:368-9. 2002
- Birth prevalence of cleft lip and palate in Northern Ireland (1981 to 2000)T A Gregg
Royal Belfast Hospital for Sick Children, 180 Falls Road, Belfast, Ireland
Cleft Palate Craniofac J 45:141-7. 2008The prevalence of cleft lip and/or palate (CL/P) in Northern Ireland (NI) was last reported for 1980 through 1990...
- Targeted scan of fifteen regions for nonsyndromic cleft lip and palate in Filipino familiesR E Schultz
Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
Am J Med Genet A 125:17-22. 2004b>Cleft lip with or without cleft palate (CL/P) is a congenital anomaly with variable birth prevalence based on geographic origins, with the highest rates commonly found in Asian populations...
- Epidemiological studies on the frequency of clefts in Europe and world-wideKarsten K H Gundlach
Rostock Interdisciplinary Center for Clefts of Lip, Alveolus and Palate and Craniofacial Anomalies, Rostock, University, Germany
J Craniomaxillofac Surg 34:1-2. 2006..Most textbooks present data on the various frequencies of clefts in different human "races". This was studied in more detail...
- The impact of orofacial clefts on quality of life and healthcare use and costsG L Wehby
Department of Health Management and Policy, College of Public Health, University of Iowa, Iowa City, IA, USA
Oral Dis 16:3-10. 2010..A summary of the primary limitations of the studies in this area is presented, along with recommendations and directions for future research...
- Progress toward discerning the genetics of cleft lipAndrew C Lidral
Department of Orthodontics, University of Iowa, Iowa City, Iowa 52242, USA
Curr Opin Pediatr 17:731-9. 2005..orofacial clefts are nonsyndromic, isolated defects, which can be separated into two different phenotypes: (1) cleft lip with or without cleft palate and (2) cleft palate only...
- Associations of folate and choline metabolism gene polymorphisms with orofacial cleftsAdrianna Mostowska
Department of Biochemistry and Molecular Biology, University of Medical Sciences, Poznan, Poland
J Med Genet 47:809-15. 2010Non-syndromic isolated cleft lip with or without cleft palate (NCL/P) is a common congenital anomaly in humans, the aetiology of which is complex and associated with both genetic and environmental factors...
- Genetic determinants of facial clefting: analysis of 357 candidate genes using two national cleft studies from ScandinaviaAstanand Jugessur
Craniofacial Development, Musculoskeletal Disorders, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Australia
PLoS ONE 4:e5385. 2009....
- Significant association between IRF6 820G->A and non-syndromic cleft lip with or without cleft palate in the Thai populationC Srichomthong
Division of Medical Genetics and Metabolism, Department of Paediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
J Med Genet 42:e46. 2005Previous data have shown an association between DNA sequence variants in the IRF6 gene and an increased risk of non-syndromic cleft lip with or without cleft palate (CL/P) in some populations.
- PAX9 and TGFB3 are linked to susceptibility to nonsyndromic cleft lip with or without cleft palate in the Japanese: population-based and family-based candidate gene analysesEisaburo Ichikawa
Department of Oral and Maxillofacial Surgery, Tokyo Dental College, Chiba, Japan
J Hum Genet 51:38-46. 2006The prevalence of nonsyndromic cleft lip with or without cleft palate (CL/P) and cleft palate only (CPO) are believed to be higher in the Japanese than in Americans, Europeans or Africans...
- Multiplex relative risk and estimation of the number of loci underlying an inherited diseasePaul Schliekelman
Department of Integrative Biology, University of California, Berkeley, USA
Am J Hum Genet 71:1369-85. 2002..point by showing that the maximum-likelihood estimate for L produced by the method of Farrall and Holder for cleft lip/cleft palate data is not consistent with the prevalence under the multiplicative model...
- First trimester exposure to corticosteroids and oral cleftsPierre Pradat
Institut Europeen des Genomutations, Lyon, France
Birth Defects Res A Clin Mol Teratol 67:968-70. 2003..The aim of this study was to test this association by a case-control analysis using the large multicentric MADRE database...
- Quality of life in adults with repaired complete cleft lip and palateA Marcusson
Department of Dentofacial Orthopedics, University Hospital, SE 581 85 Linkoping, Sweden
Cleft Palate Craniofac J 38:379-85. 2001This study evaluated the quality of life in adult Swedish subjects with repaired complete cleft lip and palate (CLP).
- Cleft lip and palate in family members of cancer survivorsE Taioli
Department of Epidemiology, SUNY Downstate Medical Center, Brooklyn, New York, USA
Cancer Invest 28:958-62. 2010The presence of cleft lip with or without cleft palate (CL/P) in family members of cancer patients was investigated...
- Soft tissue profile changes of the midface in patients with cleft lip and palate following maxillary distraction osteogenesis: a preliminary studyKiyoshi Harada
Branch of Oral Surgery, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, Yushima, Japan
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94:673-7. 2002..The purpose of this study was to examine preoperative to postoperative changes of soft tissue profiles in the midface of cleft patients who underwent maxillary distraction...
- Parent-of-origin effects for MSX1 in a Chilean population with nonsyndromic cleft lip/palateJosé Suazo
Programa de Genética Humana, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
Am J Med Genet A 152:2011-6. 2010..postulated muscle segment homeobox 1 (MSX1) as a strong candidate gene involved in the causation of nonsyndromic cleft lip with or without cleft palate (NSCLP)...
- Global oral health inequalities: challenges in the prevention and management of orofacial clefts and potential solutionsP A Mossey
University of Dundee Dental Hospital and School, Scotland, UK
Adv Dent Res 23:247-58. 2011..The future research agenda also requires engagement with implementation science to get research findings into practice...
- Infant orthopedics and facial growth in complete unilateral cleft lip and palate until six years of age (Dutchcleft)Catharina A M Bongaarts
Department of Orthodontics and Oral Biology, Radbound University Nijmegen Medical Center, The Netherlands
Cleft Palate Craniofac J 46:654-63. 2009To evaluate longitudinally the effect of infant orthopedics (IO) on dentofacial cephalometric variables in unilateral cleft lip and palate (UCLP) patients from 4 to 6 years of age.
- Early craniofacial morphology and growth in children with bilateral complete cleft lip and palateN V Hermann
Department of Pediatric Dentistry and Clinical Genetics, School of Dentistry, Copenhagen University Hospital, Denmark
Cleft Palate Craniofac J 41:424-38. 2004Analysis of craniofacial morphology and growth in children with bilateral complete cleft lip and palate (BCCLP), compared with a control group with unilateral incomplete cleft lip (UICL), before any treatment as well as 20 months after ..
- SUMO1 polymorphisms are associated with non-syndromic cleft lip with or without cleft palateTao Song
Department of Oral Maxillofacial Surgery, School of Stomatology, Harbin Medical University, Harbin, China
Biochem Biophys Res Commun 377:1265-8. 2008Small ubiquitin-like modifier 1 (SUMO1) haploinsufficiency results in cleft lip and palate in animal models. However, no studies have linked SUMO1 to non-syndromic cleft lip with or without cleft palate (NSCLP) in humans...
- Cancer risk in persons with oral cleft--a population-based study of 8,093 casesCamilla Bille
Center for the Prevention of Congenital Malformations, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Am J Epidemiol 161:1047-55. 2005..revealed only a few significant associations: an increased occurrence of breast cancer among females born with cleft lip and/or cleft palate (standardized incidence ratio (SIR) = 1.52, 95% CI: 1.05, 2...
- The multidisciplinary evaluation and management of cleft lip and palateNathaniel H Robin
Department of Genetics, University of Alabama at Birmingham, Birmingham AL 35294, USA
South Med J 99:1111-20. 2006b>Cleft lip with or without a cleft palate (CLP) and cleft palate alone (CPA) are common birth defects, with a combined birth prevalence of about 1 to 2/1,000...
- IRF6 is a risk factor for nonsyndromic cleft lip in the Brazilian populationLuciano A Brito
Human Genome Research Center, Department of Genetics, Institute de Biosciences, University of Sao Paulo, Sao Paulo, Brazil
Am J Med Genet A 158:2170-5. 2012Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a complex disorder with a worldwide incidence estimated at 1:700. Among the putative susceptibility loci, the IRF6 gene and a region at 8q24...
- Differential parental transmission of markers in RUNX2 among cleft case-parent trios from four populationsJae Woong Sull
Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA
Genet Epidemiol 32:505-12. 2008Isolated cleft lip with or without cleft palate (CL/P) is among the most common human birth defects, with a prevalence around 1 in 700 live births...
- Distraction osteogenesis in the management of severe maxillary hypoplasia in cleft lip and palate patientsPaolo Scolozzi
Division of Oral and Maxillofacial Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Geneva, Switzerland
J Craniofac Surg 19:1199-214. 2008..We used cleft lip and palate and distraction osteogenesis as key words...
- Rectangular mucosal flap with artificial dermis grafting for vermilion deformity in cleft lipsS Wakami
Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Osaka City University, Asahi 1 4 3, Abeno, Osaka 545 8585, Japan
J Plast Reconstr Aesthet Surg 63:22-7. 2010The treatment of whistling deformity in patients with cleft lip remains controversial. Previous reconstruction methods of whistling deformity have been limited in volume due to the necessity for primary closure of the donor site...
- Cleft lip with cleft palate, ankyloglossia, and hypodontia are associated with TBX22 mutationsP N Kantaputra
Department of Orthodontics and Paediatric Dentistry, and Craniofacial Genetics Laboratory, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand
J Dent Res 90:450-5. 2011..Several individuals in these families were also found to have micro/hypodontia. This study has expanded the phenotypic spectrum of TBX22-related mutations to include dental anomalies and cleft lip.
- MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palateTriin Jagomagi
Department of Stomatology, Faculty of Medicine, University of Tartu, Tartu, Estonia
Eur J Oral Sci 118:213-20. 2010..The most significant associations with nonsyndromic cleft lip with or without cleft palate (CL/P) were found for SNPs in MSX1, MTHFR, and PVRL2, including several common ..
- Association between genetic variants of reported candidate genes or regions and risk of cleft lip with or without cleft palate in the polish populationAdrianna Mostowska
Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poland
Birth Defects Res A Clin Mol Teratol 88:538-45. 2010b>Cleft lip with or without cleft palate (CL/P) is one of the most common craniofacial malformations, with a complex and multifactorial etiology...
- Dentocraniofacial morphology in parents of children with cleft lip and/or palateA Suzuki
Department of Orthodontics, Faculty of Dentistry, Kyushu University, Fukuoka, Japan
Cleft Palate Craniofac J 36:131-8. 1999The purpose of this study was to compare the dentocraniofacial morphology of parents of children with cleft lip and/or palate (CL/P) with that of parents of children without CL/P and to use the results for genetic counseling.
- TP63 gene mutations in Chinese P63 syndrome patientsW Yin
Key Laboratory for Oral Biomedical Engineering of the Ministry of Education, Hospital and School of Stomatology, Wuhan University, Luoyu Road 237, Wuhan 430079, P R China
J Dent Res 89:813-7. 2010..gene for these phenotypes in Chinese, we recruited two Chinese Ectrodactyly-Ectodermal-dysplasia-Cleft lip/palate syndrome (EEC) cases and a Limb-Mammary-Syndrome (LMS) patient to carry out TP63 gene sequencing...
- Cleft lip and palate incidence among the live births in the Republic of KoreaSukwha Kim
Department of Reconstructive Plastic Surgery, College of Medicine, Seoul National University, Seoul, Korea
J Korean Med Sci 17:49-52. 2002We present an epidemiologic study of cleft lip and palate in the Republic of Korea from January 1, 1993 through December 31, 1993. In 1993, the number of total live births was 715,817...
- Transforming growth factor-alpha (TGFA): genomic structure, boundary sequences, and mutation analysis in nonsyndromic cleft lip/palate and cleft palate onlyJ Machida
Department of Pediatrics, University of Iowa, Iowa City, Iowa, 52242, USA
Genomics 61:237-42. 1999Transforming growth factor-alpha (TGFA) has been proposed as a candidate gene in the etiology of nonsyndromic cleft lip with or without cleft palate (NS-CL/P) and of nonsyndromic cleft palate only (NS-CPO)...
- Prevalence of nonsyndromic oral clefts in Texas: 1995-1999Syed Shahrukh Hashmi
University of Texas Health Sciences Center, Houston School of Public Health, Houston, Texas, USA
Am J Med Genet A 134:368-72. 2005Nonsyndromic cleft lip with/without cleft palate (NSCLP) and nonsyndromic cleft palate only (NSCPO) are common complex birth defects affecting 4,000 newborns annually...
- Lip height and lip width after extended Mohler unilateral cleft lip repairCourt B Cutting
Institute of Reconstructive Plastic Surgery, New York University Medical Center, New York, NY 10016, USA
Plast Reconstr Surg 111:17-23; discussion 24-6. 2003..purpose of this study was to evaluate the symmetry in lip height and lip width after extended Mohler unilateral cleft lip repair, with long-term follow-up monitoring...
- Contribution of MSX1 variants to the risk of non-syndromic cleft lip and palate in a Malay populationIman Salahshourifar
Human Genome Center, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
J Hum Genet 56:755-8. 2011..Furthermore, the G110G variant displayed a significant association between patients with non-syndromic cleft lip, with or without cleft palate, and normal controls (P=0.001, odds ratio=2.241, 95% confidence interval, 1.357-3...
- The effect of cleft lip on adults' responses to faces: cross-species findingsChristine E Parsons
Department of Psychiatry, University of Oxford, Oxford, United Kingdom
PLoS ONE 6:e25897. 2011b>Cleft lip and palate is the most common of the congenital conditions affecting the face and cranial bones and is associated with a raised risk of difficulties in infant-caregiver interaction; the reasons for such difficulties are not ..
- Parental craniofacial morphology in cleft lip with or without cleft palate as determined by cephalometry: a meta-analysisS M Weinberg
Center for Craniofacial and Dental Genetics, Division of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
Orthod Craniofac Res 9:18-30. 2006To integrate findings from previous cephalometric studies comparing the craniofacial complex of unaffected parents with cleft lip with or without cleft palate (CL/P) children to controls with no history of the disease.
- Coping strategies and social support in the family impact of cleft lip and palate and parents' adjustment and psychological distressSarah R Baker
Department of Oral Health and Development, School of Clinical Dentistry, University of Sheffield, UK
Cleft Palate Craniofac J 46:229-36. 2009To examine the role of parents' coping strategies and social support in the family impact of cleft lip and palate (CLP) and levels of adjustment and psychological distress and to investigate whether a child's age, type of cleft, or other ..
- Potential economic benefit of cleft lip and palate repair in sub-Saharan AfricaBlake Alkire
Department of Plastic and Oral Surgery, Children s Hospital Boston, and Department of Global Health and Social Medicine, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
World J Surg 35:1194-201. 2011..The present study aimed to establish a methodology for valuing the potential economic benefit of surgical intervention using cleft lip and palate (CLP) in sub-Saharan Africa (SSA) as a model.
- Two novel TP63 mutations associated with the ankyloblepharon, ectodermal defects, and cleft lip and palate syndrome: a skin fragility phenotypeAimee S Payne
Department of Dermatology, University of Pennsylvania, 220 Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104, USA
Arch Dermatol 141:1567-73. 2005Ankyloblepharon, ectodermal defects, and cleft lip and palate (AEC) syndrome is a rare autosomal dominant disorder caused by mutations in the sterile alpha motif region of TP63, a homologue of the tumor suppressor TP53...
- Epidemiology of cleft lip and cleft palate in PakistanMohammed Mehboob Elahi
Division of Plastic and Reconstructive Surgery, Temple University, 1600 Arch Street, Suite 508, Philadelphia, PA 19103, USA
Plast Reconstr Surg 113:1548-55. 2004..serve as a means of establishing data important for the diagnosis, treatment, and counseling of patients with cleft lip and cleft palate...
- Unraveling human cleft lip and palate researchA R Vieira
Departments of Oral Biology and Pediatric Dentistry, School of Dental Medicine, University of Pittsburgh, PA 15261, USA
J Dent Res 87:119-25. 2008The focus of this work is to highlight the most recent advances in the understanding of cleft lip and palate occurrence...
- Secondary alveolar bone grafting: the dilemma of donor site selection and morbidityMa amon A Rawashdeh
Department Oral and Maxillofacial Surgery, Jordan University of Science and Technology, Jordan
Br J Oral Maxillofac Surg 46:665-70. 2008..Much more research and development are necessary to find a suitable carrier for rhBMP-2, and to study the properties of newly formed bone that it has induced before it can be a substitute for autogenous bone...
- Expression analyses of human cleft palate tissue suggest a role for osteopontin and immune related factors in palatal developmentLinda P Jakobsen
Wilhelm Johannsen Centre for Functional Genome Research, Department of Cellular and Molecular Medicine, Panum Institute, Copenhagen, Denmark
Exp Mol Med 41:77-85. 2009b>Cleft lip and/or palate (CL/P) is a common congenital malformation with a complex etiology which is not fully elucidated yet...
- Risk factors for oral clefts: a population-based case-control study in Shenyang, ChinaWei Wang
Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China
Paediatr Perinat Epidemiol 23:310-20. 2009..76 per 1000. The ratio of cleft lip with or without cleft palate (CL +/- P) : cleft palate only (CP) was 5.60:1...
- PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylaseChristoph Loenarz
Oxford Centre for Integrative Systems Biology, University of Oxford, Oxford, UK
Hum Mol Genet 19:217-22. 2010Mutations of human PHF8 cluster within its JmjC encoding exons and are linked to mental retardation (MR) and a cleft lip/palate phenotype...
- Mutations in BMP4 are associated with subepithelial, microform, and overt cleft lipSatoshi Suzuki
Division of Research and Treatment for Oral and Maxillofacial Congenital Anomalies, School of Dentistry, Aichi Gakuin University, Chikusa ku, Nagoya, Japan
Am J Hum Genet 84:406-11. 2009b>Cleft lip with or without cleft palate (CL/P) is a complex trait with evidence that the clinical spectrum includes both microform and subepithelial lip defects...
- Ozone and other air pollutants and the risk of oral cleftsBing Fang Hwang
Department of Occupational Safety and Health, College of Public Health, China Medical University, Taichung, Taiwan
Environ Health Perspect 116:1411-5. 2008..Air pollution influences the development of oral clefts in animals. There are few epidemiologic data on the relation of prenatal air pollution exposure and the risk of oral clefts...
- FOXE1 association with both isolated cleft lip with or without cleft palate, and isolated cleft palateLina M Moreno
Department of Orthodontics, College of Dentistry, University of Iowa, Iowa City, IA 52242, USA
Hum Mol Genet 18:4879-96. 2009..A previous genome-wide linkage scan discovered a novel locus for cleft lip with or without cleft palate (CL/P) at 9q22-q33...
- Regional anesthesia for cleft lip repair: a preliminary studyNaveen Eipe
Department of Anesthesia, Padhar Hospital, Padhar, Betul District, Madhya Pradesh 460005, India
Cleft Palate Craniofac J 43:138-41. 2006To assess whether local anesthetic blockade of the infraorbital nerve may allow for cleft lip repair to be performed under regional anesthesia.
- Cleft deformities in Zimbabwe, Africa: socioeconomic factors, epidemiology, and surgical reconstructionAnnette M Pham
Cleft and Craniofacial Program, Facial Plastic and Reconstructive Surgery, Department of Otolaryngology Head and Neck Surgery, University of California, Davis School of Medicine, 2521 Stockton Blvd, Sacramento, CA 95817, USA
Arch Facial Plast Surg 9:385-91. 2007..Although cleft lip and palate has a lower incidence in Africa (0...
- Evaluation of oral and nasal halitosis parameters in patients with repaired cleft lip and/or palateFlávio Monteiro-Amado
Hospital for Rehabilitation of Craniofacial Anomalies, Universidade of São Paulo, and Master of Science in Stomatology by Bauru Dental School, Universidade of São Paulo, Bauru, Brazil
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100:682-7. 2005The objective of this study was to investigate the relationship between halitosis parameters in patients with and without cleft lip and/or palate.
- Botulinum toxin to improve results in cleft lip repairTravis T Tollefson
Department of Otolaryngology Head and Neck Surgery, University of California, Davis Medical Center, Sacramento 95817, USA
Arch Facial Plast Surg 8:221-2. 2006
- Dental caries prevalence in children with cleft lip/palate aged between 6 months and 6 years in the West of ScotlandK F M Britton
Department of Paediatric Dentistry, Glasgow Dental Hospital and School, 378 Sauchiehall Street, Glasgow, Scotland, G2 3JZ
Eur Arch Paediatr Dent 11:236-41. 2010To compare the prevalence of dental caries in children with cleft lip/palate with national data at the same age.
- Dental and oral hygiene status in Jordanian children with cleft lip and palate: a comparison between unilateral and bilateral cleftsA M Hazza'a
Department of Oral Medicine and Oral Surgery, Jordan University of Science and Technology, Irbid, Jordan
Int J Dent Hyg 9:30-6. 2011The purpose of this study was to assess and compare the dental health and oral hygiene status of subjects with unilateral and bilateral cleft lip and palate (BCLP).
- Congenital missing permanent teeth in Korean unilateral cleft lip and alveolus and unilateral cleft lip and palate patientsSeung Hak Baek
School of Dentistry, Dental Research Institute, Seoul National University, Department of Orthodontics, Seoul, South Korea
Angle Orthod 77:88-93. 2007..maxillary lateral incisor [MLI] and maxillary second premolar [MSP]) and sidedness (cleft vs noncleft) between boys and girls in Korean unilateral cleft lip and alveolus (UCLA) and unilateral cleft lip and palate (UCLP) patients.
- Wnt9b is the mutated gene involved in multifactorial nonsyndromic cleft lip with or without cleft palate in A/WySn mice, as confirmed by a genetic complementation testDiana M Juriloff
Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
Birth Defects Res A Clin Mol Teratol 76:574-9. 2006Nonsyndromic cleft lip (CL) with or without cleft palate (CLP) is a common human birth defect with complex genetic etiology. One of the unidentified genes maps to chromosome 17q21...
- Cleft lip and palate in southwestern Iran: an epidemiologic study of live birthsMohammad Hossain Rajabian
Shiraz University of Medical Sciences, Department of Plastic Surgery, Shiraz, Iran
Ann Saudi Med 25:385-8. 2005b>Cleft lip with or without cleft palate (CL/P), is the most common congenital anomaly in the head and neck worldwide. We studied the prevalence of cleft lip (CL) and palate (CP) in Shiraz, which is located in southwestern Iran.
- A longitudinal study on influence of primary facial deformities on maxillofacial growth in patients with cleft lip and palateNorifumi Nakamura
Division of Maxillofacial Diagnostic and Surgical Sciences, Graduate School of Dental Science, Kyushu University, Maidashi, Fukuoka, Japan
Cleft Palate Craniofac J 42:633-40. 2005..use three-dimensional (3D) analysis to characterize the primary facial deformities in children with unilateral cleft lip and palate (UCLP) and then serially analyze the relationships between facial deformities and maxillofacial ..
- Susceptibility locus for non-syndromic cleft lip with or without cleft palate on chromosome 10q25 confers risk in Estonian patientsTiit Nikopensius
Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
Eur J Oral Sci 118:317-9. 2010Non-syndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common birth defects and has a multifactorial etiology that includes both genetic and environmental factors...
- MMP gene polymorphisms as contributors for cleft lip/palate: association with MMP3 but not MMP1Ariadne Letra
Department of Biological Sciences, Bauru Dental School, University of Sao Paulo, Brazil
Arch Oral Biol 52:954-60. 2007..MMPs can be considered a group of candidate proteins for the etiology of cleft lip with or without cleft palate (CL/P) due to their role in craniofacial modelling...
- Human genetic factors in nonsyndromic cleft lip and palate: an updateFrancesco Carinci
Department of D M C C C, Section of Maxillofacial Surgery, University of Ferrara, Corso, Giovecca 203, 44100 Ferrara, Italy
Int J Pediatr Otorhinolaryngol 71:1509-19. 2007Nonsyndromic cleft lip and/or palate (or orofacial cleft, OFC) is a malformation characterized by an incomplete separation between nasal and oral cavities without any associated anomalies...
- Folate-related gene polymorphisms as risk factors for cleft lip and cleft palateJames L Mills
Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Birth Defects Res A Clin Mol Teratol 82:636-43. 2008b>Cleft lip with or without cleft palate (CLP) and cleft palate only (CPO) have an inherited component and, many studies suggest, a relationship with folate...
- Craniofacial computerized tomography analysis of the midface of patients with repaired complete unilateral cleft lip and palateSunjay Suri
Discipline of Orthodontics, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
Am J Orthod Dentofacial Orthop 134:418-29. 2008..the maxillary dentoalveolar and deeper structures in patients with surgically repaired complete unilateral cleft lip and palate (CLP) and to investigate whether significant asymmetry existed in the deeper midfacial structures, ..
- Preferential associations between oral clefts and other major congenital anomaliesMonica Rittler
ECLAMC Latin American Collaborative Study of Congenital Malformations at Hospital Materno Infantil Ramón Sardá, Buenos Aires, Argentina
Cleft Palate Craniofac J 45:525-32. 2008To identify preferential associations between oral clefts (CL = cleft lip only, CLP = cleft lip with cleft palate, CP = cleft palate) and nonoral cleft anomalies, to interpret them on clinical grounds, and, based on the patterns of ..
- Factors influencing early childhood caries of cleft lip and/or palate children aged 18 to 36 months in southern ThailandTeerapong Mutarai
Orthodontic Division, Department of Preventive Dentistry, Prince of Songkhla University, Thailand
Cleft Palate Craniofac J 45:468-72. 2008..To clarify whether oral health care behavior or oral cleft status influences early childhood caries in southern Thailand cleft children...
- Oral and nasal malodor in patients with and without cleft lip and palate who had undergone orthodontic therapyCenk Doruk
Department of Orthodontics, University of Cumhuriyet, Sivas, Turkey
Cleft Palate Craniofac J 45:481-4. 2008To compare oral and nasal malodor in patients with and without cleft lip and palate (CLP) who had undergone orthodontic therapy.
- Pattern of cleft lip and palate in hospital-based population in Saudi Arabia: retrospective studyAziza Aljohar
Dentistry Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
Cleft Palate Craniofac J 45:592-6. 2008To report the patterns of cleft lip and/or cleft palate in Saudi Arabia from data collected at a tertiary care hospital.
- Cleft lip and/or palate: 10 years experience at a pediatric cleft center in Southern ThailandSomchit Jaruratanasirikul
Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand
Cleft Palate Craniofac J 45:597-602. 2008To study the clinical characteristics, demographic data, and associated congenital anomalies of pediatric patients with cleft lip and/or palate in Southern Thailand.
- Time trends in oral clefts in Chinese newborns: data from the Chinese National Birth Defects Monitoring NetworkLi Dai
National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Chengdu, 610041, China
Birth Defects Res A Clin Mol Teratol 88:41-7. 2010..Although the prevalence of oral clefts in China is among the highest in countries worldwide, little is known about its descriptive epidemiology...
- Facial cleft and associated anomalies: incidence among infants at a Jordanian medical centreH E Aqrabawi
Neonatal Unit, King Hussein Medical Centre, Amman, Jordan
East Mediterr Health J 14:356-9. 2008To estimate incidence of cleft lip and cleft palate among Jordanian infants and to identify associated anomalies, we carried out a prospective, hospital-based study over a 5-year period, January 2000-January 2005...
- Comparison of dental caries prevalence in patients with cleft lip and/or palate and their sibling controlsMahmoud Al-Dajani
College of Dentistry, International University for Science and Technology, Dara, Syria
Cleft Palate Craniofac J 46:529-31. 2009Objective: To evaluate the prevalence of dental caries in patients with cleft lip and/or palate and their cleft-free sibling controls.Methods: The two subject groups (patient and control) comprised 106 participants...
- Cleft lip and palate as a cost-effective health care treatment in the developing worldWilliam P Magee
Operation Smile, 6435 Tidewater Drive, Norfolk, Virginia 23509, USA
World J Surg 34:420-7. 2010..The authors suggest that surgery has an important role in global public health, specifically through international volunteer surgical missions as a vehicle for delivery...
- Epidemiology underpinning research in the aetiology of orofacial cleftsPeter Mossey
University of Dundee, Dental Hospital and School, Dundee, Scotland, UK
Orthod Craniofac Res 10:114-20. 2007....
- Caries prevalence in children with cleft lip and palate--a systematic review of case-control studiesPamela Hasslöf
Department of Odontology, Pediatic Dentistry, Faculty of Medicine, Umea University, Umea, Sweden
Int J Paediatr Dent 17:313-9. 2007To conduct a systematic review of literature in order to examine the evidence of an increased prevalence of dental caries in children with cleft lip and palate (CLP).
- Outcome of secondary alveolar bone grafting before and after eruption of the canine in Jordanian patients with cleft lip and palateMa amon A Rawashdeh
Department of Oral and Maxillofacial Surgery, Jordan University of Science and Technology and King Abdullah University Hospital, Cleft Lip and Palate Centre, Irbid, Jordan
J Craniofac Surg 18:1331-7. 2007This prospective study was carried out at the Cleft Lip and Palate Centre at King Abdullah University Hospital and Maxillofacial Unit at Jordan University of Science and Technology during the period of 2000 to 2006...
- Tissue engineering solutions for cleft palatesJennifer L Moreau
Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, MD, USA
J Oral Maxillofac Surg 65:2503-11. 2007..Clefts of the lip and palate are the most prevalent congenital craniofacial birth defect in humans. The developing field of tissue engineering is considered for the management of clefts of the lip and palate...
- Quality of Life in Children with CleftHillary Broder; Fiscal Year: 2009..This project will enroll children (ages 8-17) with cleft palate only (CPO) and cleft lip and palate and their caregivers who are evaluated at five renown craniofacial centers (two in the southeast and ..
- Quality of Life in Children with CleftHillary L Broder; Fiscal Year: 2010..This project will enroll children (ages 8-17) with cleft palate only (CPO) and cleft lip and palate and their caregivers who are evaluated at five renown craniofacial centers (two in the southeast and ..
- Quality of Life in Children with CleftHillary L Broder; Fiscal Year: 2010..This project will enroll children (ages 8-17) with cleft palate only (CPO) and cleft lip and palate and their caregivers who are evaluated at five renown craniofacial centers (two in the southeast and ..
- INTERNATIONAL GENETIC EPIDEMIOLOGY OF ORAL CLEFTSTerri Beaty; Fiscal Year: 2009..we successfully conducted a multi-center, international study on the genetic etiology of oral clefts (including cleft lip, CL; cleft lip and palate, CLP; and cleft palate, CP) by recruiting cases from 5 sites (Maryland, Singapore, ..
- Effects of oral clefts on birth outcomes and cleft risks due to maternal smokingGEORGE WEHBY; Fiscal Year: 2007b>Cleft lip and/or palate (CL/P) is a common birth defect with a complex ideology and large health burden. The effects of CL/P on birth outcomes such as low birth weight and prematurity have been understudied...
- Health outcomes and improved phenotypic characterization of cleft lip and palateGEORGE WEHBY; Fiscal Year: 2007b>Cleft lip and/or palate (CLP) is a common birth defect occurring in about 1/500 to 1/2500 births...
- Health outcomes and improved phenotypic characterization of cleft lip and palateGEORGE WEHBY; Fiscal Year: 2009b>Cleft lip and/or palate (CLP) is a common birth defect occurring in about 1/500 to 1/2500 births...
- Effects of Dioxin on Vietnamese CiviliansDavid Carpenter; Fiscal Year: 2004..These hospitals serve maternity patients from all of southern Vietnam. The investigators will study cases of a) cleft lip/cleft palate, b) neural tube defects, including spina bifida, anecephaly and microcephaly, and c) limb ..
- Speech Intelligibility Testing in Children with Repaired Cleft PalateDavid Zajac; Fiscal Year: 2007..underlie speech intelligibility in young children with repaired clefts of the secondary palate with or without cleft lip (Aim 1)...
- Eustachian Tube Form/Function in Cleft Lip and PalateAnil Gungor; Fiscal Year: 2004..If these predictions are valid, an early MRI study of CP infants be prognostic of the severity and longevity of ME disease and may serve to guide the type of palatal reconstruction for individual patients. ..
- VELOPHARYNGEAL FUNCTION FOR SPEECH AFTER PALATAL SURGERYWilliam Williams; Fiscal Year: 2004The incidence of cleft lip/palate is 1/750, making it one of the most common congenital malformations...
- Skin Regeneration: Cellular & Molecular MechanismsHERMANN PETER LORENZ; Fiscal Year: 2010b>Cleft lip and palate is a major health problem because of the functional defect produced. Furthermore, surgical reconstruction results in lip and palate scarring, which inhibits facial growth and oral function...
- Functional Outcomes of Cleft Lip SurgeryCARROLL TROTMAN; Fiscal Year: 2004DESCRIPTION: (from the abstract) The prevalence of cleft lip and palate in the United States is approximately 1 in 1000 live births (range of 0.7 to 1.3)...
- Gene-enviornment interactions in facial cleftsKaare Christensen; Fiscal Year: 2006..Family and twin studies have clearly indicated a genetic role in the etiology of cleft lip and palate, but environmental components play a major role, as well...
- Skin Regeneration: Cellular & Molecular MechanismsHERMANN LORENZ; Fiscal Year: 2009b>Cleft lip and palate is a major health problem because of the functional defect produced. Furthermore, surgical reconstruction results in lip and palate scarring, which inhibits facial growth and oral function...
- Cleft Lip Genetics: A Multicenter International ConsortiAndrew Lidral; Fiscal Year: 2004b>Cleft lip with or without cleft palate (CL/P) is a common birth defect. Previous studies have indicated that CL/P is a complex trait that is caused by a combination of genetic and environmental factors...
- CLONING AND CHARACTERIZATION OF THE VAN DER WOUDE GENEBrian Schutte; Fiscal Year: 2007b>Cleft lip and palate is a common congenital anomaly with significant lifelong morbidity. The extensive psychological, surgical, speech and dental involvement emphasize the importance of understanding the underlying causes...
- MOLECULAR GENETIC EPIDEMIOLOGY OF CLEFT LIP AND PALATEJeffrey Murray; Fiscal Year: 1993..funding cycle of this proposal the investigators applied these techniques to a common sentinel birth defect--cleft lip and palate...
- MOLECULAR GENETIC EPIDEMIOLOGY OF CLEFT LIP AND PALATEJeffrey Murray; Fiscal Year: 2003..Finally, using an affected pedigree member approach, we have mapped a locus for non-syndromic cleft lip and palate to 6p23...
- Growth Factor Signaling in Mouse PalatogensisYiPing Chen; Fiscal Year: 2010Non-syndromic cleft lip and cleft palate, one of the major groups of congenital birth defects in human beings...
- Growth Factor Signaling in Mouse PalatogensisYiPing Chen; Fiscal Year: 2009Non-syndromic cleft lip and cleft palate, one of the major groups of congenital birth defects in human beings...