jaundice

Summary

Summary: A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA. Clinical jaundice usually is a sign of LIVER dysfunction.

Top Publications

  1. pmc Urine metabolomics analysis for biomarker discovery and detection of jaundice syndrome in patients with liver disease
    Xijun Wang
    National TCM Key Lab of Serum Pharmacochemistry, Heilongjiang University of Chinese Medicine, Key Pharmacometabolomics Platform of Chinese Medicines, Heping Road 24, Harbin 150040, China
    Mol Cell Proteomics 11:370-80. 2012
  2. ncbi Jaundice in malaria
    Anil C Anand
    Department of Medicine, Armed Forces Medical College, Pune, India
    J Gastroenterol Hepatol 20:1322-32. 2005
  3. ncbi Fatal outbreaks of jaundice in pregnancy and the epidemic history of hepatitis E
    C G Teo
    Division of Viral Hepatitis, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    Epidemiol Infect 140:767-87. 2012
  4. pmc Estimating the burden of maternal and neonatal deaths associated with jaundice in Bangladesh: possible role of hepatitis E infection
    Emily S Gurley
    International Centre for Diarrheal Diseases Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    Am J Public Health 102:2248-54. 2012
  5. ncbi Prognostic value of jaundice in patients with gallbladder cancer by the AFC-GBC-2009 study group
    J M Regimbeau
    Department of Digestive Surgery, Amiens North Hospital, University of Picardy Medical Centre, Place Victor Pauchet, Amiens Cedex 01, France
    Eur J Surg Oncol 37:505-12. 2011
  6. pmc Aggressive natural killer-cell leukemia with jaundice and spontaneous splenic rupture: a case report and review of the literature
    Li min Gao
    Department of Pathology, West China Hospital of Sichuan University, Chengdu 610041, China
    Diagn Pathol 8:43. 2013
  7. ncbi Etiology of new-onset jaundice: how often is it caused by idiosyncratic drug-induced liver injury in the United States?
    Raj Vuppalanchi
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Gastroenterol 102:558-62; quiz 693. 2007
  8. ncbi Forced expression of murine IL-17E induces growth retardation, jaundice, a Th2-biased response, and multiorgan inflammation in mice
    G Pan
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, CA 94080, USA
    J Immunol 167:6559-67. 2001
  9. pmc The infective causes of hepatitis and jaundice amongst hospitalised patients in Vientiane, Laos
    Bounkong Syhavong
    Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
    Trans R Soc Trop Med Hyg 104:475-83. 2010
  10. ncbi Ursodeoxycholic acid and artesunate in the treatment of severe falciparum malaria patients with jaundice
    Sombat Treeprasertsuk
    Department of Gastroenterology, Chulalongkorn University, Thailand
    J Gastroenterol Hepatol 25:362-8. 2010

Detail Information

Publications266 found, 100 shown here

  1. pmc Urine metabolomics analysis for biomarker discovery and detection of jaundice syndrome in patients with liver disease
    Xijun Wang
    National TCM Key Lab of Serum Pharmacochemistry, Heilongjiang University of Chinese Medicine, Key Pharmacometabolomics Platform of Chinese Medicines, Heping Road 24, Harbin 150040, China
    Mol Cell Proteomics 11:370-80. 2012
    ..However, current diagnostic methods cannot predict typical Jaundice syndrome (JS) in patients with liver disease and little is known about the global metabolomic alterations that ..
  2. ncbi Jaundice in malaria
    Anil C Anand
    Department of Medicine, Armed Forces Medical College, Pune, India
    J Gastroenterol Hepatol 20:1322-32. 2005
    b>Jaundice is not an unusual accompaniment of malaria. It can occur due to intravascular hemolysis, disseminated intravascular coagulation, and, rarely, 'malarial hepatitis'...
  3. ncbi Fatal outbreaks of jaundice in pregnancy and the epidemic history of hepatitis E
    C G Teo
    Division of Viral Hepatitis, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    Epidemiol Infect 140:767-87. 2012
    Space-time clustering of people who fall acutely ill with jaundice, then slip into coma and death, is an alarming phenomenon, more markedly so when the victims are mostly or exclusively pregnant...
  4. pmc Estimating the burden of maternal and neonatal deaths associated with jaundice in Bangladesh: possible role of hepatitis E infection
    Emily S Gurley
    International Centre for Diarrheal Diseases Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    Am J Public Health 102:2248-54. 2012
    ..We estimated the population-based incidence of maternal and neonatal mortality associated with hepatitis E virus (HEV) in Bangladesh...
  5. ncbi Prognostic value of jaundice in patients with gallbladder cancer by the AFC-GBC-2009 study group
    J M Regimbeau
    Department of Digestive Surgery, Amiens North Hospital, University of Picardy Medical Centre, Place Victor Pauchet, Amiens Cedex 01, France
    Eur J Surg Oncol 37:505-12. 2011
    b>Jaundice is frequent in patients with gallbladder cancer (GBC) and indicates advanced disease and, according to some teams, precludes routine operative exploration...
  6. pmc Aggressive natural killer-cell leukemia with jaundice and spontaneous splenic rupture: a case report and review of the literature
    Li min Gao
    Department of Pathology, West China Hospital of Sichuan University, Chengdu 610041, China
    Diagn Pathol 8:43. 2013
    ..We report an uncommon case of 36-year-old male who showed jaundice and spontaneous splenic rupture. The diagnosis was established by the biopsy of liver and spleen...
  7. ncbi Etiology of new-onset jaundice: how often is it caused by idiosyncratic drug-induced liver injury in the United States?
    Raj Vuppalanchi
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Gastroenterol 102:558-62; quiz 693. 2007
    ..We conducted a study of adults with new-onset jaundice at a nonreferral community hospital to better understand the epidemiology of acute DILI.
  8. ncbi Forced expression of murine IL-17E induces growth retardation, jaundice, a Th2-biased response, and multiorgan inflammation in mice
    G Pan
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, CA 94080, USA
    J Immunol 167:6559-67. 2001
    ..Taken together, these findings suggest that IL-17E is a unique pleiotropic cytokine and may be an important mediator of inflammatory and immune responses...
  9. pmc The infective causes of hepatitis and jaundice amongst hospitalised patients in Vientiane, Laos
    Bounkong Syhavong
    Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
    Trans R Soc Trop Med Hyg 104:475-83. 2010
    There is little information on the diverse infectious causes of jaundice and hepatitis in the Asiatic tropics...
  10. ncbi Ursodeoxycholic acid and artesunate in the treatment of severe falciparum malaria patients with jaundice
    Sombat Treeprasertsuk
    Department of Gastroenterology, Chulalongkorn University, Thailand
    J Gastroenterol Hepatol 25:362-8. 2010
    ..The present study aims to determine the effects of combined UDCA and artesunate compared to placebo and artesunate on the improvement of liver tests in severe PF jaundiced patients...
  11. ncbi Resolution of parenteral nutrition-associated jaundice on changing from a soybean oil emulsion to a complex mixed-lipid emulsion
    Rafeeq Muhammed
    Department of Paediatric Gastroenterology, University of Birmingham, Birmingham, UK
    J Pediatr Gastroenterol Nutr 54:797-802. 2012
    Resolution of parenteral nutrition (PN)-associated jaundice has been reported in children given a reduced dose of intravenous fat using a fish oil-derived lipid emulsion...
  12. ncbi Diagnostic approach to the patient with jaundice following trauma
    K J Labori
    Department of Gastroenterological Surgery and Institute for Experimental Medical Research, Ullevaal University Hospital, Oslo, Norway
    Scand J Surg 93:176-83. 2004
    b>Jaundice in trauma patients may reflect serious underlying pathology. The aim of this review was to determine the appropriate diagnostic approach to the patient with jaundice following trauma.
  13. pmc The anatomic pattern of biliary atresia identified at time of Kasai hepatoportoenterostomy and early postoperative clearance of jaundice are significant predictors of transplant-free survival
    Riccardo Superina
    Children s Memorial Hospital, Chicago, IL, USA
    Ann Surg 254:577-85. 2011
    ..The goals of this study were to describe the clinical and anatomic features of infants undergoing Kasai portoenterostomy (KPE) for biliary atresia (BA) and to examine associations between these parameters and outcomes...
  14. ncbi The role of lamivudine and predictors of mortality in severe flare-up of chronic hepatitis B with jaundice
    H L Y Chan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    J Viral Hepat 9:424-8. 2002
    Patients with chronic hepatitis B (CHB) may develop severe disease exacerbations (flare) with jaundice, and some may progress to fulminant hepatic failure...
  15. ncbi Gilbert-Meulengracht's syndrome and pharmacogenetics: is jaundice just the tip of the iceberg?
    Christian P Strassburg
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    Drug Metab Rev 42:168-81. 2010
    ..The complexity hidden behind this pharmacogenetic abnormality is of profound significance for drug development and therapy...
  16. ncbi Association of hepatomegaly and jaundice with acute renal failure but not with cerebral malaria in severe falciparum malaria in Thailand
    M Nacher
    Unité INSERM 511, Immunobiologie Cellulaire et Moleculaire des Infections Parasitaires, Faculté de Médecine Pitié Salpêtrière, Paris, France
    Am J Trop Med Hyg 65:828-33. 2001
    ..b>Jaundice and hepatomegaly were significantly associated with renal failure (adjusted odds ratio [AOR], 3...
  17. ncbi A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice
    Hans L Tillmann
    Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA
    Gastroenterology 139:1586-92, 1592.e1. 2010
    ..We analyzed the association between IL28B and the clinical presentation of acute hepatitis C virus (HCV) infection in a homogeneous population...
  18. ncbi Trends in hospitalizations for neonatal jaundice and kernicterus in the United States, 1988-2005
    Bryan L Burke
    Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences and Arkansas Children s Hospital, Little Rock, Arkansas, USA
    Pediatrics 123:524-32. 2009
    ..nationally representative hospital discharge data to evaluate trends in the diagnosis and management of neonatal jaundice and the incidence of kernicterus in relation to the American Academy of Pediatrics hyperbilirubinemia clinical ..
  19. pmc The use of the head louse as a remedy for jaundice in Spanish folk medicine: an overview
    José Ramón Vallejo
    Departamento de Terapéutica Médico Quirúrgica, Facultad de Medicina, Universidad de Extremadura, E 06006 Badajoz, Spain
    J Ethnobiol Ethnomed 9:52. 2013
    In Spain, head lice are considered a therapeutic resource for the treatment of jaundice. All folk remedies based on the ingestion of these insects meet in the present document, previously dispersed among a large number of references.
  20. ncbi The treatment of jaundice with medicinal plants in indigenous communities of the Sub-Himalayan region of Uttarakhand, India
    Jyotsana Sharma
    Department of Botany, HNB Garhwal University, Srinagar Garhwal, Uttarakhand 246174, India
    J Ethnopharmacol 143:262-91. 2012
    ..A large number of plants and formulations have been claimed to have hepatoprotective activity. Jaundice is a symptom, indicative of the malfunctioning of the liver...
  21. ncbi Characteristics of Epstein-Barr virus hepatitis among patients with jaundice or acute hepatitis
    L J Vine
    Cornwall Gastrointestinal Unit, Royal Cornwall Hospital Truro, UK
    Aliment Pharmacol Ther 36:16-21. 2012
    ..The demographics, clinical features and outcome of EBV hepatitis are incompletely understood, particularly in the elderly people...
  22. ncbi A comparison of metal and plastic stents for the relief of jaundice in unresectable malignant biliary obstruction in Korea: an emphasis on cost-effectiveness in a country with a low ERCP cost
    Won Jae Yoon
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
    Gastrointest Endosc 70:284-9. 2009
    ..In countries where ERCP costs are low relative to those of metal stents (eg, Korea), initial endoscopic retrograde biliary drainage (ERBD) with a plastic stent is thought to be more economical...
  23. ncbi [Primary research on daily administration times of rhubarb used to treat experimental jaundice in rats]
    Junlan Lv
    302 Military Hospital of China, Beijing 100039, China
    Zhongguo Zhong Yao Za Zhi 36:3506-10. 2011
    To study the rational daily administration times of rhubarb when it is used to treat experimental jaundice in rats, at the same time, validate the accuracy and feasibility of the method which was previously established to research the ..
  24. ncbi Jaundice predicts advanced disease and early mortality in patients with gallbladder cancer
    William G Hawkins
    Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg Oncol 11:310-5. 2004
    In patients with gallbladder cancer, jaundice suggests tumor involvement of the porta hepatis. This study reports on the prevalence, etiology, and clinical significance of jaundice in patients with gallbladder cancer.
  25. ncbi Markedly prolonged jaundice from simultaneous infection with hepatitis E virus and leptospira
    Asuka Suzuki
    Department of Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Kurume Med J 50:155-9. 2003
    ..Leptospirosis appeared to have altered the course of hepatitis E virus infection in this patient, even though infection with Leptospira was cleared with antibiotics by 50 days after the onset of the hepatitis symptoms...
  26. ncbi Jaundice accompanied by giant cell hepatitis and eosinophilia in childhood
    Nanda Kerkar
    Mount Sinai Medical Center, New York, New York 10029 6574, USA
    Semin Liver Dis 24:107-11. 2004
  27. doi Mirizzi syndrome presenting as painless jaundice: a rare entity diagnosed by EUS
    Mario Pelaez-Luna
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Gastrointest Endosc 67:974-5; discussion 975. 2008
  28. ncbi A comparison of ultrasound, computed tomography and endoscopic retrograde cholangiopancreatography in the differential diagnosis of benign and malignant jaundice and cholestasis
    P A Pasanen
    Department of Surgery, Kuopio University Hospital, Finland
    Eur J Surg 159:23-9. 1993
    ..endoscopic retrograde cholangiopancreatography (ERCP) in distinguishing between benign and malignant causes of jaundice and cholestasis without jaundice. DESIGN--Prospective study. SETTING--University Hospital in Finland...
  29. ncbi Considerations on early diagnosis of carcinoma of the pancreas
    Marco Elli
    Università degli Studi di Milano Ospedale Luigi Sacco, Via G B Grassi, 72, 20157 Milano, Italy
    Hepatogastroenterology 50:2205-7. 2003
    ..Pancreas carcinoma is seldom recognized at an early stage. Through an attentive retrospective evaluation of the patient's history a frequent pattern of early presentation is sought...
  30. ncbi Jaundice in falciparum malaria--some prospective observations
    Rachna Mazumder
    Department of Medicine, Medical College, Kolkata
    J Indian Med Assoc 100:312-4. 2002
    ..The present prospective study of slide positive Plasmodium falciparum patients revealed a higher (17%) incidence of jaundice. This is much higher than reported earlier...
  31. ncbi Postoperative jaundice
    Thomas W Faust
    Division of Gastroenterology, Department of Internal Medicine, The University of Pennsylvania School of Medicine, 3 Ravdin, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Clin Liver Dis 8:151-66. 2004
    ..The type of surgery to be performed should also be reviewed. All patients with postoperative jaundice should be evaluated for a history of liver disease...
  32. pmc An unusual cause of jaundice
    P J D Owen
    Centre for Endocrine and Diabetes Sciences, University Hospital of Wales, Cardiff
    BMJ 335:773-4. 2007
  33. doi Four cases of coexistent thyrotoxicosis and jaundice: results of radioiodine treatment and a brief review
    Madhavi Chawla
    All India Institute of Medical Sciences, New Delhi, India
    Thyroid 18:289-92. 2008
  34. ncbi Granulocytic sarcoma of the colon and leukemic infiltration of the liver in a patient presenting with hematochezia and jaundice
    Alper Sevinc
    Department of Medical Oncology, Gaziantep University, School of Medicine Sahinbey Medical Center, Gaziantep TR 27310, Turkey
    Digestion 69:262-5. 2004
    ..rare case of GS of the colon and liver infiltration in a 60-year-old male patient with AML presenting with jaundice and hematochezia and review the literature...
  35. pmc Co-amoxiclav jaundice: clinical and histological features and HLA class II association
    J O'Donohue
    Department of Gastroenterology, Gartnavel General Hospital, Glasgow G12 0YN, UK
    Gut 47:717-20. 2000
    b>Jaundice associated with co-amoxiclav has been increasingly recognised. We aimed to characterise its clinical and histological features and to investigate linkage with human leucocyte antigen class II haplotypes.
  36. pmc Jaundice in African-American and Hispanic patients with AIDS
    Abbasi J Akhtar
    Charles R Drew University of Medicine and Science, Los Angeles, CA, USA
    J Natl Med Assoc 99:1381-5. 2007
    ..in hepatic biochemical tests are common in patients with acquired immunodeficiency syndrome (AIDS), overt jaundice is infrequent...
  37. ncbi Acute hepatitis with or without jaundice: a predominant presentation of acute Q fever in southern Taiwan
    Ko Chang
    Division of Infectious Diseases, Department of Internal Medicine, National Cheng Kung University, University Hospital, 138 Sheng Li Road, Tainan, Taiwan 704, ROC
    J Microbiol Immunol Infect 37:103-8. 2004
    ..Acute febrile illness, hepatitis, and pneumonia are the 3 most common manifestations of this condition, whereas jaundice is rarely reported among patients with acute Q fever...
  38. pmc Castleman disease presenting with jaundice: a case with the multicentric hyaline vascular variant
    Jun Bean Park
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Korean J Intern Med 22:113-7. 2007
    ..A previous healthy 50 year-old man was hospitalized for right upper quadrant (RUQ) abdominal pain. He had jaundice and a 1 cm-sized lymph node in the right supraclavicular area...
  39. ncbi Genetic testing for Gilbert's syndrome: how useful is it in determining the cause of jaundice?
    A S Rudenski
    Department of Clinical Biochemistry, Addenbrooke s Hospital, Cambridge, UK
    Clin Chem 44:1604-9. 1998
    ..Until these values for prevalence and penetrance are known, genetic testing for Gilbert's syndrome cannot be recommended on a routine basis...
  40. ncbi Antibiotic therapy: a major cause of drug-induced jaundice in southwest England
    Syed H Hussaini
    Cornwall Gastrointestinal Unit, Royal Cornwall Hospital Truro, Cornwall, UK
    Eur J Gastroenterol Hepatol 19:15-20. 2007
    To determine the incidence and causes of drug-induced jaundice in a rural community.
  41. ncbi Jaundice in critical illness: promoting factors of a concealed reality
    Nicola Brienza
    Emergency and Organ Transplantation Department, Anaesthesia and Intensive Care Unit, University of Bari, P zza G Cesare 11, 70124, Bari, Italy
    Intensive Care Med 32:267-74. 2006
    ..The aim of this study was to assess risk factors for LD in critically ill patients...
  42. ncbi Biliary drainage, photodynamic therapy and chemotherapy for unresectable cholangiocarcinoma with jaundice
    David Fuks
    Federation of Digestive Diseases, Amiens North Hospital, Jules Verne University of Picardy, Amiens, France
    J Gastroenterol Hepatol 24:1745-52. 2009
    ..The combination of photodynamic therapy and biliary stenting seems to be beneficial in the palliative treatment of unresectable cholangiocarcinoma. We aimed to assess the accuracy of photodynamic therapy in a single centre...
  43. ncbi Preoperative resolution of jaundice following biliary stenting predicts more favourable early survival in resected pancreatic ductal adenocarcinoma
    Richard A Smith
    Division of Surgery and Oncology, School of Cancer Studies, Royal Liverpool University Hospital, 5th Floor UCD Building, Daulby St, Liverpool L69 3GA, UK
    Ann Surg Oncol 15:3138-46. 2008
    ..The objective of this study was to investigate the influence of preoperative biliary stenting and resolution of jaundice on subsequent postoperative survival following resection for pancreatic cancer.
  44. ncbi (TA)n UGT 1A1 promoter polymorphism: a crucial factor in the pathophysiology of jaundice in G-6-PD deficient neonates
    Michael Kaplan
    Department of Neonatology, Shaare Zedek Medical Center, Jerusalem 91031, Israel
    Pediatr Res 61:727-31. 2007
    ..8 +/- 3.4 mg/dL, p = 0.02). In the steady state, similar rates of hemolysis, but increased PTB in the G-6-PD- deficient, (TA)7/(TA)7 homozygotes, imply that (TA)7/(TA)7, homozygosity is central to increased PTB...
  45. ncbi Urinary tract infection in term neonates with prolonged jaundice
    Nader Pashapour
    Department of Pediatrics, Imam Hospital, Urmia University of Medical Sciences, Urmia, Iran
    Urol J 4:91-4; discussion 94. 2007
    The aim of this study was to evaluate the frequency of urinary tract infection (UTI) in neonates with prolonged jaundice.
  46. ncbi Fever, jaundice, altered sensorium, with multiple systemic manifestations
    Kim Vaiphei
    Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh 160 012, India
    Indian J Gastroenterol 26:82-6. 2007
  47. ncbi A randomized controlled trial of ursodeoxycholic acid in patients with alcohol-induced cirrhosis and jaundice
    Gilles Pelletier
    Department of Gastroenterology of Hôpital Bicêtre, Assistance Publique Hôopitaux de Paris, Paris, France
    Hepatology 37:887-92. 2003
    ..assess the efficacy of ursodeoxycholic acid (UDCA) on the survival of patients with alcohol-induced cirrhosis and jaundice. We included patients with histologically proven alcohol-induced cirrhosis and serum bilirubin >50 micromol/L...
  48. ncbi Jaundice as an early diagnostic sign of urinary tract infection in infancy
    Francisco J Garcia
    Division of Emergency and Transport Medicine, Childrens Hospital Los Angeles, Los Angeles, California, USA
    Pediatrics 109:846-51. 2002
    ..Previous studies have noted that jaundice may be one of the first signs of a bacterial infection in infants...
  49. ncbi Successful transcatheter chemoembolization for acute jaundice in a patient with advanced hepatocellular carcinoma and portal vein tumor thrombosis: a case report
    Keisuke Inui
    Division of Cardiology, Hepatology, Geriatrics, and Integrated Medicine, Department of Internal Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 76:217-20. 2009
    ..0 and 20.0 mg/dL), and biliary obstruction by the tumor appeared to have caused this sudden jaundice. To treat the biliary obstruction, selective transcatheter chemoembolization (TACE) was performed via the feeding ..
  50. ncbi Outbreak of jaundice and hemorrhagic fever in the Southeast of Brazil in 2001: detection and molecular characterization of yellow fever virus
    A M B de Filippis
    Laboratório de Flavivirus, Departamento de Virologia, Instituto Oswaldo Cruz, FIOCRUZ, RJ, Brasil
    J Med Virol 68:620-7. 2002
    Between January and March 2001, an outbreak of jaundice and hemorrhagic fever occurred in the state of Minas Gerais, Southeast region of Brazil, in which a mortality rate of 53% was reported...
  51. ncbi [A young man with acute generalised jaundice and intermittent epigastric pain]
    B Walz
    Klinik fur Innere Medizin, Gastroenterologie, Hämato Onkologie und Diabetologie, Ludwigsburg
    Dtsch Med Wochenschr 133:129-32. 2008
    A 24-year-old Iraqi was admitted to our hospital with acute generalised jaundice and intermittent epigastric pain. His family doctor suspected a viral hepatitis...
  52. ncbi Neonatal jaundice
    M Jeffrey Maisels
    Department of Pediatrics, William Beaumont Hospital, Royal Oak, Michigan, USA
    Pediatr Rev 27:443-54. 2006
  53. doi Hepatitis E and jaundice in an HIV-positive pregnant woman
    Jan Thoden
    AIDS 22:909-10. 2008
  54. ncbi Evaluation of the physician's ability to recognize the presence or absence of anemia, fever, and jaundice
    O L Hung
    Department of Emergency Medicine, Bellevue Hospital Center, New York University Medical Center, New York 10016, USA
    Acad Emerg Med 7:146-56. 2000
    ..The objective of this study was to evaluate the ability of the clinician to detect the presence and discriminate the extent of clinical anemia, fever, and jaundice in an ED or hospitalized patient.
  55. ncbi Helminth infections are associated with protection from malaria-related acute renal failure and jaundice in Thailand
    M Nacher
    , , , Paris, France
    Am J Trop Med Hyg 65:834-6. 2001
    ..16 [0.03-0.85], P = 0.03). Helminth-infected controls were less likely to have jaundice (AOR, 0.39 [0.16-0.96], P = 0.04) or to have peripheral mature schizonts (AOR, 0.2 [0.07-0.62], P = 0...
  56. ncbi The significance of serum hepatocyte growth factor levels in planning follow-up of postoperative jaundice-free patients with biliary atresia
    Keiichi Uchida
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu Mie 514 8507, Japan
    J Pediatr Surg 41:1657-62. 2006
    ..to clarify the significance of serum hepatocyte growth factor (HGF), interleukin (IL)-6, and IL-1 receptor antagonist (ra) levels in the evaluation of disease status in jaundice-free survivors with biliary atresia after Kasai operation.
  57. pmc Jaundice due to extrabiliary gallstones
    Scott Stevens
    Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    JSLS 7:277-9. 2003
    ..We present a case in which gallstones spilled during cholecystectomy, causing near circumferential, extraluminal common hepatic duct compression, and clinical jaundice 1 year later.
  58. ncbi The spectrum of surgical jaundice in infancy
    Mark Davenport
    Department of Paediatric Surgery, Kings College Hospital, Denmark Hill, London, England, UK
    J Pediatr Surg 38:1471-9. 2003
    Conjugated jaundice arising during infancy may be caused by a number of different surgical conditions...
  59. ncbi Case records of the Massachusetts General Hospital. Case 3-2006. A 63-year-old woman with jaundice and a pancreatic mass
    Robert H Schapiro
    Gastrointestinal Unit, Massachusetts General Hospital, USA
    N Engl J Med 354:398-406. 2006
  60. pmc Epidemic jaundice: Harvard's 5th General Hospital at Musgrave Park in World War II
    John Hedley-Whyte
    Anaesthesia and Respiratory Therapy, Harvard University, Boston, MA 02132 4927, USA
    Ulster Med J 74:122-5. 2005
  61. ncbi Postoperative jaundice after cardiac surgery
    Aikaterini Mastoraki
    Department of Surgical Intensive Care Unit, Onassis Cardiac Surgery Center, 356 Sygrou Ave, 17674 Athens, Greece
    Hepatobiliary Pancreat Dis Int 6:383-7. 2007
    ..The purpose of this study was to investigate the incidence and nature of postoperative jaundice in patients undergoing cardiac operation, to analyze the determinants, and to identify the clinical significance ..
  62. ncbi A case of a small cell lung carcinoma presenting with jaundice due to pancreatic metastasis
    Aysin Sakar
    Department of Chest Diseases, Faculty of Medicine, Celal Bayar University, Manisa, Turkey
    Tuberk Toraks 53:181-4. 2005
    ..incidence of pancreatic metastasis of lung cancer has been reported in autopsy series, symptomatic cases with jaundice due to that is very rare...
  63. ncbi Clinicopathologic features of ampullary carcinoma without jaundice
    Terumi Kamisawa
    Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Honkomagome, Tokyo, Japan
    J Clin Gastroenterol 40:162-6. 2006
    To evaluate clinicopathological features of ampullary carcinoma without jaundice.
  64. ncbi Postoperative jaundice and total parenteral nutrition-associated hepatic dysfunction
    Chuhan Chung
    Division of Gastroenterology and Hepatology, Northwestern University Medical School, 676 North St Clair Street, Suite 880, Chicago, IL 60611, USA
    Clin Liver Dis 6:1067-84. 2002
    Postoperative jaundice and TPN-induced hepatic abnormalities represent clinical situations that stem from multiple and frequently overlapping insults to the liver...
  65. ncbi Clinical value of serum tumour markers CEA, CA 50 and CA 242 in the distinction between malignant versus benign diseases causing jaundice and cholestasis; results from a prospective study
    P A Pasanen
    Department of Surgery, Kuopio University Hospital, Finland
    Anticancer Res 12:1687-93. 1992
    A prospective study of 113 patients with jaundice and 20 patients with unjaundiced cholestasis was carried out to evaluate the value of serum tumour markers, carcinoembryonic antigen (CEA) and monoclonal antibodies CA 50 and CA 242, in ..
  66. ncbi Reappraising the portoenterostomy procedure according to sound physiologic/anatomic principles enhances postoperative jaundice clearance in biliary atresia
    Hiroki Nakamura
    Department of Pediatric General and Urogenital Surgery, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    Pediatr Surg Int 28:205-9. 2012
    ..Now PE involves an extended lateral dissection and a wide anastomosis (extended PE: EPE). We reappraised KOPE and created our-KOPE (OKOPE) by adhering strictly to its principles and techniques. We compared outcome of EPE and OKOPE...
  67. ncbi Jaundice in falciparum malaria; changing trends in clinical presentation--a need for awareness
    Tasnim Ahsan
    Department of Medicine, Jinnah Poastgraduate Medical Centre, and Postgraduate Training Institute, Karachi, Pakistan
    J Pak Med Assoc 58:616-21. 2008
    To describe the clinical characteristics, laboratory parameters and prognostic factors in patients with falciparum malaria (FM) with jaundice.
  68. pmc A 40-year-old woman who developed jaundice during therapy for thyrotoxicosis
    Chukwuma Ogbonna Ekpebegh
    Department of Medicine, Faculty of Health Sciences, University of Cape Town, Groote Schuur Hospital, Cape Town, South Africa
    PLoS Med 3:e12. 2006
  69. ncbi Infectious aetiology of jaundice among pregnant women in Angola
    Roland T Strand
    Division of International Health IHCAR, Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden
    Scand J Infect Dis 35:401-3. 2003
    The contribution of viral hepatitis, human immunodeficiency virus (HIV) infection and malaria to jaundice among pregnant women in Luanda, Angola, was studied...
  70. pmc Arsphenamine jaundice and the recognition of instrument-borne virus infection
    P P Mortimer
    Hepatitis and Retrovirus Laboratory, Virus Reference Division, London, UK
    Genitourin Med 71:109-19. 1995
    ..Soon after its introduction in 1910, intravenous arsphenamine treatment for syphilis was found to be complicated by jaundice. The underlying cause, unsterile syringes and needles, was eventually recognised in the early 1940s, mainly ..
  71. ncbi Jaundice in the intensive care unit
    Vishal Bansal
    Department of Surgery, University of California at San Diego, San Diego, CA, USA
    Surg Clin North Am 86:1495-502. 2006
    Hyperbilirubinemia, or jaundice, is common in the ICU, with incidence up to 40% among critically ill patients. Unfortunately, it is poorly understood in the critically ill, and too often presents a diagnostic dilemma to the ICU physician...
  72. ncbi Does the presence of jaundice and/or a lump in a patient with gall bladder cancer mean that the lesion is not resectable?
    Vibha Varma
    Gyan Burman Hepatobiliary Unit, Department of Surgical Gastroenterology and Liver Transplantation, Sir Ganga Ram Hospital, New Delhi 110060, India
    Dig Surg 26:306-11. 2009
    The presence of jaundice or an abdominal lump in gall bladder cancer (GBC) is often translated to advanced and unresectable disease. We examined whether this was true.
  73. ncbi Jaundice in the adult patient
    Sean P Roche
    Department of Family and Community Medicine, Albany Medical College, Albany, New York 12208, USA
    Am Fam Physician 69:299-304. 2004
    b>Jaundice in an adult patient can be caused by a wide variety of benign or life-threatening disorders. Organizing the differential diagnosis by prehepatic, intrahepatic, and posthepatic causes may help make the work-up more manageable...
  74. ncbi Infectious haemolytic anaemia causes jaundice outbreaks in seawater-cultured coho salmon, Oncorhynchus kisutch (Walbaum), in Chile
    P A Smith
    Unit of Pathology of Aquatic Animals, Department of Animal Pathology, Faculty of Veterinary Sciences, University of Chile, Santiago de Chile, Chile
    J Fish Dis 29:709-15. 2006
    ..At necropsy, fish from field cases exhibited signs of jaundice accompanied by pale light-brown livers and dark spleens...
  75. ncbi Acute hepatitis E with severe jaundice: report of three cases
    Rami Moucari
    Hepatology Department and INSERM U773, CRB3, University of Paris VII, Beaujon Hospital, Clichy, France
    Eur J Gastroenterol Hepatol 19:1012-5. 2007
    ..Infection is endemic in developing countries. Disease course is benign, and severe jaundice is rarely reported. Three patients presented to our department with symptomatic acute hepatitis...
  76. pmc The "jaundice hotline" for the rapid assessment of patients with jaundice
    Jonathan Mitchell
    Gastrointestinal Unit, Royal Cornwall Hospital, Truro TR1 3LJ
    BMJ 325:213-5. 2002
    Patients with jaundice require rapid diagnosis and treatment, yet such patients are often subject to delay.
  77. ncbi An unusual presentation of acute brucellosis with fever, jaundice and maculopapular rash
    Ayten Kadanali
    Int J Infect Dis 10:409-10. 2006
  78. ncbi Atypical MRI features of a biliary cystadenoma revealed by jaundice
    Guillaume Baudin
    Service d Imagerie Medicale, Centre Hospitalier Régional et Universitaire de Nice, Hopital Archet 2, F 06202 Nice cedex 3, France
    Clin Imaging 30:413-5. 2006
    ..A left hepatectomy finally revealed a mucinous cystadenoma with pseudo-ovarian stroma that had a pedunculated intraductal extension to the biliary convergence...
  79. ncbi Jaundice noted in the first 24 hours after birth in a managed care organization
    Thomas B Newman
    Department of Epidemiology and Biostatistics, The University of California, San Francisco, Campus Box 0560, San Francisco, CA 94143, USA
    Arch Pediatr Adolesc Med 156:1244-50. 2002
    To investigate the significance of jaundice noted in the first 24 hours after birth in a community setting.
  80. ncbi A serological study of leptospirosis among hospitalized jaundice patients in and around Kolkata
    C Debnath
    Indian J Med Microbiol 23:68-9. 2005
  81. ncbi Plant sources for the treatment of jaundice in the tribals of Western Madhya Pradesh of India
    S Samvatsar
    School of Life Sciences, Devi Ahilya Vishwa Vidyalaya, Khandwa Road Campus, 452001, Indore, India
    J Ethnopharmacol 73:313-6. 2000
    A survey of the tribals of Western Madhya Pradesh of India for the treatment of jaundice has yielded 13 plants for this purpose. Part of the plant used, dosage, duration, restriction on intake of food etc. has been reported.
  82. ncbi Glucose-6-phosphate dehydrogenase deficiency and Gilbert syndrome: a gene interaction underlies severe jaundice without severe hemolysis
    P Nicolaidou
    Third Department of Pediatrics, University of Athens, Attikon Hospital, Athens, Greece
    Pediatr Hematol Oncol 22:561-6. 2005
    ..the paradoxical clinical phenotype of an undetected severe hemolysis in parallel with the development of severe jaundice in a 13-year-old male suffering from a confirmed interaction of glucose-6-phosphate dehydrogenase deficiency (..
  83. ncbi Jaundice and hepatocellular damage associated with nevirapine therapy
    M Prakash
    Division of Infectious Diseases, Keck School of Medicine, Los Angeles, California, USA
    Am J Gastroenterol 96:1571-4. 2001
    ..No patient was rechallenged with the drug. CONCLUSION: Nevirapine can be associated with icteric hepatitis, which appears to be reversible after withdrawal of the drug...
  84. ncbi The effect of jaundice on the generation of anti-gastrin antibodies in G17DT immunized patients with advanced pancreatic cancer
    A S Takhar
    Academic Unit of Cancer Studies, D Floor, West Block, Queen s Medical Centre, University Hospital, Nottingham NG7 2UH, UK
    Eur J Surg Oncol 32:197-200. 2006
    ..The aim of this study was to determine the ability of G17DT to generate anti-gastrin antibodies in jaundiced patients with biliary obstruction due to advanced pancreatic cancer...
  85. ncbi Predicting factor of quality of life in long-term jaundice-free survivors after the Kasai operation
    Keiichi Uchida
    Second Department of Surgery, Mie University School of Medicine, Tsu, Mie, Japan
    J Pediatr Surg 39:1040-4. 2004
    The aim of this study was to determine simple predictors for quality of life (QOL) in long-term jaundice-free survivors after the Kasai operation.
  86. ncbi [Differential diagnosis of jaundice]
    B Mullhaupt
    Abteilung für Gastroenterologie und Hepatologie DIM, Universitatsspital Zurich
    Praxis (Bern 1994) 93:898-903. 2004
    b>Jaundice, a common condition with many different causes, is marked by yellow discoloration of the sclerae, mucous membranes and skin...
  87. ncbi Patient with markedly elevated CA 19-9 not associated with malignancy
    Douglas Lowe
    Department of Internal Medicine, Section of Gastroenterology Hepatology, Medical College of Georgia and Veterans Administration Medical Center, Augusta, GA 30912, USA
    South Med J 99:306-8. 2006
    A 66-year-old white male presented with jaundice, pruritus, and a 30-pound weight loss over two months. Physical examination revealed scleral icterus...
  88. ncbi High frequency of cholestasis in generalized pustular psoriasis: Evidence for neutrophilic involvement of the biliary tract
    Manuelle Viguier
    Department of Dermatology 1, Hopital Saint Louis, Assistance Publique Hôpitaux de Paris and Université Paris 7, Paris, France
    Hepatology 40:452-8. 2004
    ..Eleven patients (50%) had pronounced abnormalities: jaundice (4/22), gammaglutamyl transferase higher than 5 times the normal value (10/22), alkaline phosphatase higher than ..
  89. ncbi Serum bilirubin levels and mortality after myeloablative allogeneic hematopoietic cell transplantation
    Ted A Gooley
    Section of Clinical Statistics, Clinical Research Division, Fred Hutchinson Cancer Research Center, and the University of Washington School of Medicine, Seattle, WA 98109 1024, USA
    Hepatology 41:345-52. 2005
    ..of serum bilirubin levels with nonrelapse mortality by day +200, testing the hypothesis that the duration of jaundice up to a given point in time provides more prognostic information than either the maximum bilirubin value or the ..
  90. ncbi Acute viral hepatitis C-induced jaundice in pregnancy
    Tsung Ying Hsieh
    Department of Obstetrics and Gynecology, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan
    Taiwan J Obstet Gynecol 45:180-2. 2006
    Acute viral hepatitis C-induced jaundice in pregnancy is very rare and may be fatal. Here, we report a complicated case with acute hepatitis C-induced jaundice in pregnancy with successful management.
  91. ncbi [A rare cause of a central bile duct stricture]
    S Kersting
    Klinik und Poliklinik für Viszeral, Thorax und Gefasschirurgie, Universitatsklinikum Carl Gustav Carus, Dresden
    Dtsch Med Wochenschr 131:973-6. 2006
    A 55 year old female patient was diagnosed because of painless jaundice and weight loss. She had undergone conventional cholecystectomy 15 years before.
  92. ncbi [Prevention of clogging of biliary stents by administration of levofloxacin and ursodeoxycholic acid]
    Carmelo Sciume
    Sezione di Chirurgia Generale ad Indirizzo Toracico, Universita degli Studi di Palermo, Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone
    Chir Ital 56:831-7. 2004
    ..by placement of a stent during ERCP, but this is often complicated by clogging of the stent with subsequent jaundice and/or cholangitis. Stent clogging may be caused by microbiological adhesion and biliary stasis...
  93. ncbi Calculated in vivo free bilirubin levels in the central nervous system of Gunn rat pups
    Monica J Daood
    Department of Pediatrics, Division of Newborn Medicine, University of Pittsburgh School of Medicine, Magee Womens Research Institute, Pittsburgh, Pennsylvania 15213, USA
    Pediatr Res 60:44-9. 2006
    ....
  94. ncbi The effect of preoperative biliary drainage on postoperative complications after pancreaticoduodenectomy
    M E Sewnath
    Department of Surgery, Academic Medical Center Amsterdam, University of Amsterdam, The Netherlands
    J Am Coll Surg 192:726-34. 2001
    ..had received preoperative internal biliary drainage were divided into three groups corresponding with severity of jaundice according to preoperative plasma bilirubin levels: < 40 microM (n = 177), 40 to 100 microM (n = 32), and > 100 ..
  95. ncbi PLGA-microsphere mediated clearance of bilirubin in temporarily hyperbilirubinemic rats: an alternate strategy for the treatment of experimental jaundice
    N Ahmad
    Inter Disciplinary Biotechnology Unit, Aligarh Muslim University, India
    Biochim Biophys Acta 1760:227-32. 2006
    ..On the basis of results of the present study, we suggest that microsphere-based delivery system may help in development of safe, effective and alternate strategy for the treatment of hyperbilirubinemic conditions in model animals...
  96. ncbi Urinary tract infections in infants: comparison between those with conjugated vs unconjugated hyperbilirubinaemia
    Hung Chang Lee
    Department of Paediatrics, Mackay Memorial Hospital, Taiwan Department of Paediatrics, Taipei Medical Uinversity, Taiwan
    Ann Trop Paediatr 25:277-82. 2005
    ..The aim was to investigate conjugated and unconjugated hyperbilirubinaemia in association with urinary tract infection (UTI) in young infants...
  97. ncbi [Diagnostics for diseases of the gallbladder and biliary tract from the viewpoint of the internist and surgeon. Demands made on radiological diagnostics]
    F M Reimann
    Krankenhaus Salem, Heidelberg
    Radiologe 45:968, 970-5. 2005
    b>Jaundice and colic pain of the right upper quadrant are the main symptoms of biliary diseases. Gallstone-related diseases often lead to hospital admission...
  98. ncbi Using BiliCheck for preterm neonates in a sub-intensive unit: diagnostic usefulness and suitability
    Daniele De Luca
    Division of Neonatology, A Gemelli University Hospital, Catholic University of the Sacred Heart, Rome, Italy
    Early Hum Dev 83:313-7. 2007
    ..is thought to be lacking in the disadvantages of old devices and could be potentially useful for diagnosing jaundice in preterm babies...
  99. ncbi [Jaundice]
    Dominique Charles Valla
    Dominique Charles Valla
    Rev Prat 55:1607-13. 2005
  100. ncbi Niacin toxicity: a rare presentation mimicking malignancy
    Abraham Joseph
    Fairmont Medical Center, 800 Clinic Circle, Fairmont, MN 56031, USA
    Age Ageing 35:448. 2006
  101. ncbi Bilhemia: a fatal complication following percutaneous placement of a transhepatic inferior vena cava catheter in a child
    Sergio Sierre
    Department of Interventional Radiology, Hospital de Pediatria Prof JP Garrahan, Pichincha 1850, Buenos Aires, Argentina
    Pediatr Radiol 37:498-500. 2007
    ..The biloma was percutaneously drained, but a biliary-venous fistula led to a rapidly progressive and fatal bilhemia. We report this case as an infrequent complication of transhepatic catheterization...

Research Grants62

  1. Regulation of Cell Signaling by Human Biliverdin Reductase
    Mahin D Maines; Fiscal Year: 2013
    ..Indeed, a compromised BVR activity causes "green jaundice", which is nearly always fatal...
  2. Predicting Bilirubin-induced Auditory Toxicity in Infants with Severe Jaundice
    Sanjiv B Amin; Fiscal Year: 2010
    Severe jaundice causes chronic post-kernicteric encephalopathy, sensori-neural hearing loss (SNHL), and auditory neuropathy (AN) in infants...
  3. Deriving hepatocytes from disease specific iPS to treat metabolic liver disorders
    Namita Roy-Chowdhury; Fiscal Year: 2013
    ..iPSC) derived from the skin of patients with Crigler-Najjar syndrome type 1 (CN1), who have severe lifelong jaundice due to uridinediphosphoglucuronate glucuronosltransferase-1 (UGT1A1) deficiency can be corrected genetically, and ..
  4. Sterile Hepatic Inflammation
    Wajahat Zafar Mehal; Fiscal Year: 2012
    ..This results in a very high degree of morbidity due to fatigue, jaundice, ankle swelling and pruritis...
  5. Lab-on-a-chip for Neonatal Hyperbilirubinemia Screening
    Vijay Srinivasan; Fiscal Year: 2012
    ..In cases of prolonged jaundice, measurement of total bilirubin alone does not suffice...
  6. Randomized Trial of Antenatal Late Preterm Steroids (ALPS) - Clinical Coordinatin
    Ronald Wapner; Fiscal Year: 2012
    ..Late preterm infants are more likely to suffer complications such as respiratory distress, hypothermia, and jaundice and are readmitted to the hospital more frequently than infants born at term...
  7. Anti HCV Protease Activities of Metalloporphyrins
    Warren N Schmidt; Fiscal Year: 2013
    ..protoporphyrin have already been approved for selective therapeutic actions in humans such as the porphyrias and jaundice of the newborn...
  8. Immunologic dysfunction in biliary atresia
    Jorge A Bezerra; Fiscal Year: 2013
    ..It results from an inflammatory and fibrosing obstruction of extrahepatic bile ducts that presents as neonatal jaundice. Despite prompt diagnosis and surgical treatment, the disease progresses and causes substantial morbidity and ..
  9. Risk factors for encephalopathy in newborns with severe hyperbilirubinemia
    RICHARD PARTRIDGE WENNBERG; Fiscal Year: 2010
    ..early postnatal discharge of infants without adequate monitoring and predisposing population risk factors for jaundice have resulted in a very high prevalence of babies admitted with severe hyperbilirubinemia and a high incidence of ..
  10. DNA methylation in biliary development and disease
    Randolph P Matthews; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Biliary atresia (BA) is the most common cause of obstructive jaundice in infants and is lethal if uncorrected...
  11. Circulating miRNA as a biomarker for biliary atresia
    Joshua R Friedman; Fiscal Year: 2013
    ..in the US The diagnosis is often delayed due to a failure to distinguish the disease from physiologic neonatal jaundice. Conversely, the diagnostic work-up of the jaundiced infant is extensive, including blood tests, ultrasonography, ..
  12. Determining Prevalence of Acute Bilirubin Encephalopathy in Developing Countries
    Tina Marye Slusher; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Section Neonatal jaundice may be the most under-recognized cause of neonatal morbidity and mortality in the developing world...
  13. JAUNDICE NEXT: A diagnostic tool for cholestatic liver disease.
    Frank Zemlan; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Cholestasis (or pathologic jaundice) is the most common sign of liver disease in children and often results from mutations in genes that play a critical role in bile formation and transport...
  14. Late adverse Impact of Getting Hyperbilrubinemia or photo Therapy (LIGHT) study
    Thomas B Newman; Fiscal Year: 2013
    ..or photoTherapy (LIGHT) study will fill two key knowledge gaps that prevent evidence- based treatment of jaundice in newborns: 1) it is not known to what extent high bilirubin levels increase the risks of cerebral palsy and ..
  15. Point-of Care System for Determination of Bilirubin Capacity in Neonates
    GLEN D RAMSAY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Uncontrolled hyperbilirubinemia (jaundice) in neonates has long been known to lead to neurological dysfunction including irreversible athetoid cerebral palsy with speech, ocular and hearing ..
  16. Point-of Care System for Determination of Bilirubin Capacity in Neonates
    GLEN D RAMSAY; Fiscal Year: 2010
    ..binding sites is a key factor in assessing risk for bilirubin associated brain damage, management of neonatal jaundice remains based upon proxies, such as gestational age and birth weight along with the bilirubin level...
  17. Multiplex platform for point of care newborn screening of hyperbilirubinemia
    NICHOLAS TROTTA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Jaundice is the most common condition that requires urgent medical attention in some newborns and is the result of elevation in circulating unconjugated bilirubin...
  18. Detection and Diagnosis of Pancreatic Cancer
    David Gold; Fiscal Year: 2009
    ..The most common symptoms of the disease, jaundice, abdominal pain, and weight loss, together with other presenting factors are nonspecific in nature...
  19. Investigation of the mechanism by which NPC1 dysfunction leads to liver disease
    Laura Liscum; Fiscal Year: 2012
    ..NPC patients suffer from cholestasis, prolonged jaundice, and hepatosplenomegaly. The mechanism by which NPC1 protein dysfunction leads to liver disease is unknown...
  20. Breastfeeding the Late Preterm Infant: A Grounded Theory Study
    Jill Radtke Demirci; Fiscal Year: 2012
    ..these data is that late preterm infants who are breastfed tend to present with diagnoses of failure to thrive, jaundice, and dehydration at much higher rates than those who are not breastfed, a finding largely attributed to ..
  21. Detection and Diagnosis of Pancreatic Carcinoma
    David V Gold; Fiscal Year: 2013
    ..The most common symptoms of the disease, jaundice, abdominal pain, and weight loss, together with other presenting factors are nonspecific in nature...
  22. Peptides surface modification to prevent stent blockage
    Joseph Leung; Fiscal Year: 2006
    ..stent blockage is the major complication of endoscopic stenting for the palliation of malignant obstructive jaundice. Bacteria adhere to the stent surface with their pili and also through the production of glycocalyx to form a ..
  23. Dystonia in an Animal Model of Kernicterus
    Steven Shapiro; Fiscal Year: 2007
    ..continue to be major complications of bilirubin toxicity despite advances in the treatment of hyperbilirubinemia (jaundice) in newborns...
  24. BILIRUBIN TOXICITY IN THE AUDITORY SYSTEM
    Steven Shapiro; Fiscal Year: 2005
    ..continue to be major complications of bilirubin toxicity despite advances in the treatment of hyperbilirubinemia (jaundice) in newborns...
  25. Bilirubin and Photobilirubin: Metabolism & Exretion
    Antony McDonagh; Fiscal Year: 2005
    Long-term objectives of this proposal are to fully elucidate the mechanism and effects of phototherapy of neonatal jaundice, to improve its effectiveness and safety, and to define the molecular mechanisms involved in the transport, ..
  26. THE UNSUSPECTED SMALL STONE STUDY (USSS)
    James DiSario; Fiscal Year: 2000
    ..Secondary endpoints include rates of severe morbidity, mortality, abdominal pain, jaundice, abnormal serum liver tests, abnormal transcutaneous abdominal ultrasound examinations, quality of life indices, ..
  27. Neonatal Phototherapy / Bilirubin Excretion
    DAVID LIGHTNER; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Jaundice is the most common clinical diagnosis in the newborn, with 60% of neonates displaying significant unconjugated hyperbilirubinemia during the first 3 days of life...
  28. Lab-on-a-chip for Neonatal Hyperbilirubinemia Screening
    Vijay Srinivasan; Fiscal Year: 2009
    ..the recommendation to measure total serum bilirubin level or cutaneous bilirubin level of all infants with jaundice in the first 24 hours of life...
  29. FAST PHOTOSENSITIZED REACTIONS OF AROMATIC COMPOUNDS
    LEONARD GROSSWEINER; Fiscal Year: 1992
    ..g., in "PUVA" therapy of psoriasis, light therapy of neonatal jaundice, and photodynamic therapy (PDT) of malignant tumors...
  30. BILIARY ATRESIA IN THE INV MOUSE
    David Perlmutter; Fiscal Year: 2000
    ..a transgenic mouse in which a recessive insertional disruption of the inv locus results in situs inversus and jaundice, is a mouse model of BA associated with situs inversus...
  31. Biosynthesis and Physiology of Vitamin B12 in Prokaryotes
    MICHIKO TAGA; Fiscal Year: 2009
    ..B12 deficiency, which plagues over 20% of elderly individuals, can cause hematological disorders, jaundice, loss of coordination, and dementia...
  32. GENE EXPRESIION WITH ADENOVIRUS-MEDIATED TRANSFER
    Frederick Askari; Fiscal Year: 2001
    ..Crigler-Najjar syndrome type 1, familial non-hemolytic jaundice and kernicterus, is a fatal disease, which can potentially be cured by genetic complementation...
  33. GORDON RESEARCH CONFERENCE ON PYRROLES
    SAMUEL BEALE; Fiscal Year: 1990
    ..P-450), erythropoiesis (heme and hemoglobin synthesis), nutrition (vitamin B12), liver development (neonatal jaundice) and environmental toxicology (chemical-induced defects in pyrrole and pyrrole-dependent drug metabolism)...
  34. IMMUNE RESPONSE TO ADENOVIRAL GENE TRANSFER
    Frederick Askari; Fiscal Year: 2000
    ..Crigler-Najjar syndrome type I, familial non-hemolytic jaundice and kernicterus, is a fatal disease which can potentially be cured by genetic complementation...
  35. CHILDREN AS RESEARCH SUBJECTS: HISTORY AND ETHICS
    PAUL EDELSON; Fiscal Year: 2001
    ..the development of therapy for childhood leukemia (1955-60), the introduction of phototherapy for neonatal jaundice (1970s), the Extracorporeal Membrane Oxygenator (1980s), and the use of Azidothymidine to prevent perinatal HIV ..
  36. PERINATAL FACTORS AND BREAST CANCER
    Dimitrios Trichopoulos; Fiscal Year: 2000
    ..to examine the observed positive association between breast cancer risk and prematurity and neonatal jaundice; and, to study the effect of other indicators of intrauterine environment, such as maternal overweight, parity, ..
  37. UT Southwestern: Clinical Site for the Drug-Induced Liver Injury Network
    William M Lee; Fiscal Year: 2012
    ..3) We propose a therapeutic trial using N-acetylcysteine for DILI cases that meet criteria for severe injury approximating Hy Zimmerman's law, that is, an acute illness with attendant jaundice.
  38. HYPERBILIRUBINEMIA TREATMENT WITH CLONED THERMO-ENZYMES
    Larry Allen; Fiscal Year: 1993
    ..applicant's abstract):ThermoGen proposes the development of bioreactors and injectable drugs for the treatment of jaundice. These will be based on cloned thermophilic bilirubin oxidizing enzyme...
  39. USE OF AN LED ARRAY FOR NEONATAL PHOTOTHERAPY
    DANIELLE ROSEN; Fiscal Year: 2000
    Hyperbilirubinemia (Jaundice) affects many term and most preterm infants. When infants are exposed to blue light (410 to 460 nanometers), a photochemical reaction occurs in the skin...
  40. MAJIC, MAKING ADVANCES AGAINST JAUNDICE IN INFANT CARE
    R Palmer; Fiscal Year: 2002
    ..to the American Academy of Pediatrics clinical practice guideline for the care of the healthy term newborn with jaundice. Two large managed care organizations will partner with the core research team, enlisting specific patient care ..
  41. Human Cellular Immune Responses to Leptospira
    Gary Klimpel; Fiscal Year: 2009
    ..seroconversion to undifferentiated febrile syndrome, with or without aseptic meningitis, to fulminant jaundice, renal failure and hemorrhage with a fatality rate up to approximately 25%...
  42. PATHOGENESIS OF LEPTOSPIROSIS
    Albert Ko; Fiscal Year: 2001
    ..In leptospirosis, multisystem complications can develop which include jaundice, acute renal failure, pulmonary hemorrhage and severe anemia...
  43. HEME AND SULFITE METABOLISM IN AMPHIBIANS
    Antony McDonagh; Fiscal Year: 1993
    ..These studies are related to liver metabolism, liver disease and jaundice in humans and to the toxicological and biochemical effects to sulfite, a common food additive and environmental ..
  44. DEVELOPMENT SUBSEQUENT TO JAUNDICE OF THE NEWBORN
    JEAN JEW; Fiscal Year: 1980
    Following neonatal jaundice, the facts concerning subsequent child development including possible cerebral dysfunction have not been easy to define...
  45. Nanoparticle Coating to Increase Biliary Stent Patency
    ANTHONY GILETTO; Fiscal Year: 2005
    Biliary stenting is a common practice to relieve the symptoms of jaundice due to an obstruction of the bile duct...
  46. Role of Cytokines and Autoimmunity in Murine BA
    Cara Mack; Fiscal Year: 2005
    ..Abrogation or amelioration of the biliary disease after the onset of jaundice will be determined by the use of cytokine or chemokine neutralizing antibodies...
  47. REGULATORY MECHANISMS IN HEPATIC METABOLISM
    Merle Olson; Fiscal Year: 1999
    ..of systemic and hepatic injury such as endotoxic shock, hepatic ischemia/reperfusion injury, and obstructive jaundice. Successful outcomes from the proposed research will provide mechanistic insight into the role and the importance ..
  48. THE ROLE OF NOTCH SIGNALING IN BILE DUCT DEVELOPMENT
    Kathleen Loomes; Fiscal Year: 2004
    ..These mice demonstrate congenital heart defects, renal tubular abnormalities, jaundice and bile duct paucity...
  49. Jaundice Chip: Diagnostic tool for cholestatic liver dis
    Jorge Bezerra; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Cholestasis (or pathologic jaundice) is the most common sign of liver disease in children, and results from genetic defects in genes that play a critical role in bile formation and ..
  50. Regulation of Bilirubin Metabolism by the Receptor CAR
    Wendong Huang; Fiscal Year: 2005
    ..overall goals of this project are to extend this finding to human CAR and begin to explore its role in neonatal jaundice as well as its role in mediating a well-known Chinese medicine in the treatment of jaundice...
  51. GENE THERAPY FOR INHERITED JAUNDICE
    Jayanta Roy Chowdhury; Fiscal Year: 2007
    ..abstract_text> ..
  52. Radioactive Stenting of malignant Biliary Obstructions
    Stephen Bunker; Fiscal Year: 2003
    Luminal obstructive symptoms such as dysphagia, vomitus, jaundice, or ileus are often the first symptoms noticed by patients or physicians and unfortunately, usually indicate an advanced stage of gastrointestinal disease associated with ..
  53. PERINATAL AND ADOLESCENT FACTORS IN BREAST CANCER
    Sherri Stuver; Fiscal Year: 2002
    ..growth; to examine the association between perinatal complications, such as pregnancy pre-eclampsia/eclampsia, jaundice, and prematurity, and indicators of sexual maturity and somatic growth during adolescence...
  54. MANAGEMENT OF HYPERBILIRUBINEMIA IN NEWBORNS
    Attallah Kappas; Fiscal Year: 2000
    ..The follow-on will also determine, in term infants with jaundice from a variety of causes, whether SnMP can control the subsequent rate of increase of plasma bilirubin ..
  55. Biostatic Coatings to Prevent Biliary Stent Occlusions
    RAINER GRUENING; Fiscal Year: 2004
    ..duct obstruction, up to one third of all plastic stents become occluded after about 4 months, resulting in jaundice and requiring stent replacement...
  56. SELECTIVE SENSOR FOR PREDICTION OF NEONATAL JAUNDICE
    William Buttner; Fiscal Year: 1993
    ..This system will be useful for the prediction of neonatal jaundice, since carbon monoxide is generated during heme degradation and exhaled. However...
  57. NEONATAL BILIRUBIN NEUROTOXICITY AND P-GLYCOPROTEIN
    Jon Watchko; Fiscal Year: 2007
    ..and LLC-PK1 cells tranfected with the gene for human or murine Pgp) and the Gunn rat model of neonatal jaundice to characterize the role of Pgp in protecting against bilirubin-induced apoptosis, the apoptotic pathways ..
  58. Therapeutic Use of Heme Analogs: Absorption in Intestine
    David Stevenson; Fiscal Year: 2009
    Neonatal jaundice occurs in 60-70% of all newborn infants. It is due to hyperbilirubinemia caused not only by an overproduction of bilirubin, but also by a transient failure to excrete this metabolite...
  59. Chromium Mesoporphyrin in the Prevention of Neonatal Jaundice
    David K Stevenson; Fiscal Year: 2010
    Neonatal jaundice occurs in 60-70% of all newborn infants. It is caused not only by an overproduction of bilirubin, but also by a transient failure to excrete this metabolite...