phototoxic dermatitis

Summary

Summary: A nonimmunologic, chemically induced type of photosensitivity producing a sometimes vesiculating dermatitis. It results in hyperpigmentation and desquamation of the light-exposed areas of the skin.

Top Publications

  1. ncbi Phototoxic and photoallergic skin reactions
    Liborija Lugović
    Department of Dermatology and Venereology, University Hospital Sestre Milosrdnice, Zagreb, Croatia
    Coll Antropol 31:63-7. 2007
  2. ncbi Ketoprofen: experimental overview of dermal toxicity
    Byoung Seok Lee
    Preclinical Center, R and D Center, AmorePacific Corporation, 314 1 Boradong, Giheung gu, Yongin si, Gyeonggi Do, 449 729, South Korea
    Arch Toxicol 81:743-8. 2007
  3. ncbi Phototoxicity assessment of drugs and cosmetic products using E. coli
    K Verma
    Photobiology Division, Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Post Box No 80, Lucknow 226001, UP, India
    Toxicol In Vitro 22:249-53. 2008
  4. ncbi Analytical studies on photochemical behavior of phototoxic substances; effect of detergent additives on singlet oxygen generation
    Satomi Onoue
    Analytical Research and Development, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Japan Inc, 5 2 Taketoyo, Aichi, 470 2393, Japan
    Pharm Res 25:861-8. 2008
  5. ncbi Safety studies of topical imiquimod 5% cream on normal skin exposed to ultraviolet radiation
    Kays Kaidbey
    KGL, Inc Ivy Laboratories, University City Science Center, 3401 Market Street, Suite 226 and Suite 232, Philadelphia, PA 19104 3355, USA
    Toxicology 178:175-82. 2002
  6. doi Mitigating photosensitivity of erythropoietic protoporphyria patients by an agonistic analog of alpha-melanocyte stimulating hormone
    Juergen H Harms
    Stadtspital Triemli, Central Laboratory, University Hospital of Zurich, Zurich, Switzerland
    Photochem Photobiol 85:1434-9. 2009
  7. ncbi Phytophotodermatitis in 19 children admitted to hospital and their differential diagnoses: Child abuse and herpes simplex virus infection
    Karen Carlsen
    Department of Dermatology at Bispebjerg Hospital, Copenhagen, Denmark
    J Am Acad Dermatol 57:S88-91. 2007
  8. ncbi Experimental phytophotodermatitis
    N E L Gonçalves
    Catholic University of Pelotas, Pelotas, Brazil
    Photodermatol Photoimmunol Photomed 21:318-21. 2005
  9. ncbi Structure-phototoxicity relationship in Balb/c mice treated with fluoroquinolone derivatives, followed by ultraviolet-A irradiation
    Koichi Yabe
    Drug Safety Research Laboratory, Daiichi Pharmaceutical Co Ltd, 16 13, Kita Kasai 1 Chome, Edogawa ku, Tokyo 134 8630, Japan
    Toxicol Lett 157:203-10. 2005
  10. ncbi Photosensitivity to exogenous agents
    Lela Lankerani
    Department of Dermatology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Cutan Med Surg 8:424-31. 2004

Detail Information

Publications116 found, 100 shown here

  1. ncbi Phototoxic and photoallergic skin reactions
    Liborija Lugović
    Department of Dermatology and Venereology, University Hospital Sestre Milosrdnice, Zagreb, Croatia
    Coll Antropol 31:63-7. 2007
    ..The treatment of these reactions includes identification and avoidance of offending agent and application of anti-inflammatory dressings, ointments and corticosteroids...
  2. ncbi Ketoprofen: experimental overview of dermal toxicity
    Byoung Seok Lee
    Preclinical Center, R and D Center, AmorePacific Corporation, 314 1 Boradong, Giheung gu, Yongin si, Gyeonggi Do, 449 729, South Korea
    Arch Toxicol 81:743-8. 2007
    ..In this animal study, no primary irritation, cumulative irritation, skin sensitization or skin phototoxicity was observed with KP treatment. However, we identified photosensitization as the underlying cause of KP dermal toxicity...
  3. ncbi Phototoxicity assessment of drugs and cosmetic products using E. coli
    K Verma
    Photobiology Division, Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Post Box No 80, Lucknow 226001, UP, India
    Toxicol In Vitro 22:249-53. 2008
    ..coli is introduced as one of the alternate test system for phototoxicity studies in safety evaluation of various chemical ingredients or formulations used in cosmetics and drugs...
  4. ncbi Analytical studies on photochemical behavior of phototoxic substances; effect of detergent additives on singlet oxygen generation
    Satomi Onoue
    Analytical Research and Development, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Japan Inc, 5 2 Taketoyo, Aichi, 470 2393, Japan
    Pharm Res 25:861-8. 2008
    ..The aim of this investigation was to clarify the possible role of biomimetic vehicle systems on the photochemical properties of phototoxic compounds, focusing on the singlet oxygen generation...
  5. ncbi Safety studies of topical imiquimod 5% cream on normal skin exposed to ultraviolet radiation
    Kays Kaidbey
    KGL, Inc Ivy Laboratories, University City Science Center, 3401 Market Street, Suite 226 and Suite 232, Philadelphia, PA 19104 3355, USA
    Toxicology 178:175-82. 2002
    ..Three randomized, open-label or assessor-blinded, placebo-controlled studies were carried out to assess its safety on normal white skin exposed to ultraviolet radiation (UVR)...
  6. doi Mitigating photosensitivity of erythropoietic protoporphyria patients by an agonistic analog of alpha-melanocyte stimulating hormone
    Juergen H Harms
    Stadtspital Triemli, Central Laboratory, University Hospital of Zurich, Zurich, Switzerland
    Photochem Photobiol 85:1434-9. 2009
    ..The findings demonstrate beneficial effects of afamelanotide in patients with EPP. Due to the limited number of patients enrolled and the design being an open-label study, confirmation by a large-scale trial is required...
  7. ncbi Phytophotodermatitis in 19 children admitted to hospital and their differential diagnoses: Child abuse and herpes simplex virus infection
    Karen Carlsen
    Department of Dermatology at Bispebjerg Hospital, Copenhagen, Denmark
    J Am Acad Dermatol 57:S88-91. 2007
    ..Phytophotodermatitis is a non-immunologic cutaneous reaction that can be provoked after contact with plants containing psoralens followed by sun exposure...
  8. ncbi Experimental phytophotodermatitis
    N E L Gonçalves
    Catholic University of Pelotas, Pelotas, Brazil
    Photodermatol Photoimmunol Photomed 21:318-21. 2005
    ....
  9. ncbi Structure-phototoxicity relationship in Balb/c mice treated with fluoroquinolone derivatives, followed by ultraviolet-A irradiation
    Koichi Yabe
    Drug Safety Research Laboratory, Daiichi Pharmaceutical Co Ltd, 16 13, Kita Kasai 1 Chome, Edogawa ku, Tokyo 134 8630, Japan
    Toxicol Lett 157:203-10. 2005
    ..These results demonstrate that phototoxicity induced by quinolones would be related to the property of the eighth position...
  10. ncbi Photosensitivity to exogenous agents
    Lela Lankerani
    Department of Dermatology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Cutan Med Surg 8:424-31. 2004
    ..To better understand cutaneous photosensitivity reactions, a review of its etiologic factors, clinical characteristics, pathogenesis, and treatment modalities was undertaken...
  11. ncbi [Reactions of the skin to solar radiation]
    M Schlaak
    Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum Leipzig
    MMW Fortschr Med 147:32-4, 37. 2005
    ..Moderate exposure to the sun after prior gradual acclimatization is to be recommended. Patients with increased photosensitivity require special photoprotective agents...
  12. ncbi Phototoxicity of bituminous tars-correspondence between results of 3T3 NRU PT, 3D skin model and experimental human data
    D Jirova
    National Reference Center for Cosmetics, National Institute of Public Health, Srobarova 48, 100 42 Prague 10, Czech Republic
    Toxicol In Vitro 19:931-4. 2005
    ..In addition to the results obtained in 3T3 NRU PT, further testing on 3D skin models may better reflect bioavailability of a given chemical in the skin, relevant to the situation in humans...
  13. ncbi Study on the mechanism of photosensitive dermatitis caused by ketoprofen in the guinea pig
    Takashi Nakazawa
    Research Laboratories 2, Fuji Yakuhin Co Ltd, 331 0068, Saitama, Japan
    Arch Toxicol 80:442-8. 2006
    ....
  14. ncbi Thioridazine induces immediate and delayed erythema in photopatch test
    Hirotsugu Takiwaki
    Department of Dermatology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Photochem Photobiol 82:523-6. 2006
    ..Thioridazine-derived oxidants and/or thioridazine radicals generated during UVA irradiation seem to play an important role in this unique phototoxic reaction...
  15. ncbi 5-(3-Phenylpropoxy)psoralen and 5-(4-phenylbutoxy)psoralen: mechanistic studies on phototoxicity
    C W Bode
    Institute of Pharmacy, Department of Pharmaceutical Chemistry, Christian Albrechts University Kiel, Germany
    Pharmazie 60:225-8. 2005
    ....
  16. ncbi [New findings on the structure-phototoxicity relationship and photostability of fluoroquinolones]
    Norihiro Hayashi
    New Lead Pharmacology Laboratory, Institute for Medical Research, Wakunaga Pharmaceutical Co, Ltd, Akitakata City 739 1195, Japan
    Yakugaku Zasshi 125:255-61. 2005
    ..We also discovered a mildly phototoxic 8-chloro quinolone which did not have increased photostability...
  17. ncbi Phototoxicity of exogenous protoporphyrin IX and delta-aminolevulinic acid in the photo hen's egg test
    Norbert J Neumann
    Department of Dermatology, Heinrich Heine University Duesseldorf, Moorenstrasse 5, D 40225 Duesseldorf, Germany
    Photodermatol Photoimmunol Photomed 20:224-9. 2004
    ..PDT should optimally leave peritumoral tissues unaffected, but only few data are reported on the effects and the time course of ALA-induced porphyrins in tumor-free tissues...
  18. ncbi Tobacco smoke is phototoxic
    M Placzek
    Klinik und Poliklinik für Dermatologie and Allergologie, Ludwig Maximilians Universitat Munchen, Frauenlobstrasse 9 11, 80337 Munich, Germany
    Br J Dermatol 150:991-3. 2004
    ..Both cigarette smoke and ultraviolet (UV) radiation are known to cause changes of the skin which can be regarded as premature ageing...
  19. ncbi Photoprotective effects of sulindac against ultraviolet B-induced phototoxicity in the skin of SKH-1 hairless mice
    Mohammad Athar
    Department of Dermatology and Skin Disease Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Toxicol Appl Pharmacol 195:370-8. 2004
    ....
  20. pmc New findings on the structure-phototoxicity relationship and photostability of fluoroquinolones with various substituents at position 1
    Norihiro Hayashi
    Institute for Medical Research, Wakunaga Pharmaceutical Co, Ltd, Hiroshima 739 1195, Japan
    Antimicrob Agents Chemother 48:799-803. 2004
    ..We also discovered a mildly phototoxic 8-chloro quinolone which did not have increased photostability...
  21. ncbi Effect of pH on uptake and photodynamic action of chlorin p6 on human colon and breast adenocarcinoma cell lines
    Mrinalini Sharma
    Biomedical Applications Section, Centre for Advanced Technology, Indore 452 013, India
    Photochem Photobiol Sci 3:231-5. 2004
    ..Additionally, the lower photosensitivity of lysosomes as compared to mitochondria in these cells suggests chlorin p6 is taken up through diffusion rather than endocytosis...
  22. ncbi High throughput screening (HTS) for phototoxicity hazard using the in vitro 3T3 neutral red uptake assay
    P A Jones
    Safety and Environmental Assurance Centre, Unilever Colworth, Sharnbrook, Bedfordshire MK44 1LQ, UK
    Toxicol In Vitro 17:703-8. 2003
    ..Any material selected for further development and inclusion in a formulation may require further confirmatory testing, e.g. using a human skin model assay for phototoxicity...
  23. ncbi Preclinical safety profile of plasma prepared using the INTERCEPT Blood System
    V Ciaravino
    Cerus Corporation, Concord, California 94520, USA
    Vox Sang 85:171-82. 2003
    ..Extensive toxicology studies were performed to characterize the safety of the photochemical treatment process for its intended use with plasma...
  24. ncbi Broad-spectrum sunscreens prevent the secretion of proinflammatory cytokines in human keratinocytes exposed to ultraviolet A and phototoxic lomefloxacin
    P Reinhardt
    Lasers and Electro Optics Division, Consumer and Clinical Radiation Protection Bureau, Product Safety Program, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON K1A 1C1, Canada
    Can J Physiol Pharmacol 84:221-6. 2006
    ..In conclusion, the application of broad-spectrum sunscreen by individuals exposed to UVA radiation may prevent phototoxic reactions initiated by drugs such as LOM...
  25. ncbi UV-B phototoxic effects induced by atorvastatin
    Marie Claude Marguery
    Arch Dermatol 142:1082-4. 2006
  26. doi Reactive oxygen species assay-based risk assessment of drug-induced phototoxicity: classification criteria and application to drug candidates
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    J Pharm Biomed Anal 47:967-72. 2008
    ..These results verify the usefulness of the ROS assay for understanding the phototoxicity risk of pharmaceutical substances, and the ROS assay can be used for screening purposes in the drug discovery stage...
  27. pmc Phototoxicity and cytotoxicity of fullerol in human lens epithelial cells
    Joan E Roberts
    Department of Natural Sciences, Fordham University, 113 West 60th Street, New York City, NY 10023, USA
    Toxicol Appl Pharmacol 228:49-58. 2008
    ..Before fullerols are used to deliver drugs to the eye, they should be tested for photo- and cytotoxicity in vivo...
  28. doi Photocontact allergic and phototoxic studies of chlorproethazine
    Alastair Kerr
    Photobiology Unit, Ninewells Hospital and Medical School, Dundee, UK
    Photodermatol Photoimmunol Photomed 24:11-5. 2008
    ..Its active ingredient is the phenothiazine chlorproethazine (CPE). Before its withdrawal, we investigated the photocontact allergic and phototoxic potential of Neuriplege cream and CPE...
  29. ncbi Topical photodynamic therapy for dermatologic disorders: results and complications
    Kelley Pagliai Redbord
    Laser and Skin Surgery Center of Indiana, St Vincent Hospital, Indianapolis, IN 46032, USA
    J Drugs Dermatol 6:1197-202. 2007
    ..In 1999, the US FDA approved PDT for the treatment of nonhyperkeratotic actinic keratoses (AKs) on the face and scalp...
  30. ncbi An evaluation of the effects of photoactivation of bithionol, amiodarone and chlorpromazine on human keratinocytes in vitro
    Linzi Reid
    FRAME Alternatives Laboratory, School of Biomedical Sciences, University of Nottingham, Nottingham, UK
    Altern Lab Anim 35:471-85. 2007
    ..This type of approach could indicate the likely mechanisms of phototoxicity of chemicals in vitro, with relevance to potential effects in vivo...
  31. ncbi Theoretical study of ibuprofen phototoxicity
    Klefah A K Musa
    Department of Natural Sciences, Orebro University, 701 82 Orebro, Sweden
    J Phys Chem B 111:13345-52. 2007
    ....
  32. ncbi Modeling the photochemistry of the reference phototoxic drug lomefloxacin by steady-state and time-resolved experiments, and DFT and post-HF calculations
    Mauro Freccero
    Department of Organic Chemistry, University of Pavia, Via Taramelli 10, 27100 Pavia, Italy
    Chemistry 14:653-63. 2008
    ..These findings suggest that the mutagenic activity of the DNA-intercalated drug involves attack of the photogenerated cation to the heterocyclic bases...
  33. ncbi Phototoxicity of bergamot oil assessed by in vitro techniques in combination with human patch tests
    K Kejlova
    National Reference Center for Cosmetics, National Institute of Public Health, Srobarova 48, 100 42 Prague 10, Czech Republic
    Toxicol In Vitro 21:1298-303. 2007
    ..Although the study showed the usefulness of the tiered testing strategy, currently, the extrapolation of in vitro results to human situation may be performed only to a limited extent...
  34. ncbi Photodegradation and in vitro phototoxicity of aceclofenac
    F Vargas
    Laboratorio de Fotoquimica, Centro de Quimica, Instituto Venezolano de Investigaciones Cientificas I V I C, Caracas, Venezuela
    Pharmazie 62:337-41. 2007
    ..No photoinduced binding was observed after irradiation of compounds 1 in the presence of human serum albumin...
  35. ncbi In vitro phototoxicity test using artificial skin with melanocytes
    Jong Hee Lee
    Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Aging Research, Clinical Research Institute Seoul, Seoul, Korea
    Photodermatol Photoimmunol Photomed 23:73-80. 2007
    ..Exposure to ultraviolet radiation (UVR) has been shown to induce cutaneous biological changes and phototoxic reactions...
  36. ncbi Water soluble fraction of solar-simulated light-exposed crude oil generates phosphorylation of histone H2AX in human skin cells under UVA exposure
    Yuko Ibuki
    Laboratory of Radiation Biology, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka shi 422 8526, Japan
    Environ Mol Mutagen 48:430-9. 2007
    ..These findings demonstrate that exposure of crude oil to sunlight makes the WSF phototoxic, generating DSBs accompanying the appearance of gamma-H2AX in human skin cells...
  37. ncbi Identification of potential anti-photoageing algal compounds using an in-vitro model of photoageing
    F Debacq-Chainiaux
    Laboratory of Biochemistry and Cellular Biology, Department of Biology, University of Namur FUNDP, Belgium
    J Pharm Pharmacol 58:1577-83. 2006
    ..One algal extract was shown to be particularly protective against UVB-induced SIPS. The results obtained here reinforce the notion that UVB-induced premature senescence of HDFs can be used to screen potential anti-photoageing compounds...
  38. ncbi Scientific problems of photosensitivity
    Ruta Dubakiene
    Republican Center of Allergology, Vilnius University, Antakalnio 124, Vilnius 10200, Lithuania
    Medicina (Kaunas) 42:619-24. 2006
    ....
  39. ncbi [Solar urticaria]
    S Schauder
    Universitäts Hautklinik Göttingen, Goettingen
    Hautarzt 54:952-8. 2003
    ..A list is attached listing the dermatology departments with photodiagnostic units in Germany, Austria, and Switzerland...
  40. ncbi [What is the cause of sunlight-induced rash?]
    Peter Stiefelhagen
    MMW Fortschr Med 145:4-8, 10. 2003
  41. ncbi Isolation and identification of the photodegradation products of the photosensitizing antidepressant drug clomipramine. Phototoxicity studies on erythrocytes
    N Canudas
    Laboratorio de Fotoquímica y Fotobiología, Departamento de Quimica, Universidad Simon Bolivar, Caracas, Venezuela
    Pharmazie 57:405-8. 2002
    ..A mechanism involving singlet oxygen, radicals and photoproducts is suggested for the reported phototoxicity...
  42. ncbi Phototoxic lesions induced by quinolone antibacterial agents in auricular skin and retina of albino mice
    K Shimoda
    Drug Safety Research Center, Daiichi Pharmaceutical Co, Ltd, Tokyo, Japan
    Toxicol Pathol 21:554-61. 1993
    ..Therefore, this method is thought to be useful to examine morphological changes caused by quinolone phototoxicity...
  43. ncbi [Photosensitivity induced skin diseases]
    M Kiec-Swierczynska
    Przychodnia Chorób Zawodowych Instytut Medycyny Pracy, Łódź
    Med Pr 52:383-7. 2001
    ..The cases of occupational eczema in farmers and gardeners induced by the effect of light sensitizing plants have also been reported. In addition, the photoallergy diagnostic methods are discussed...
  44. ncbi Studies on the photostability and phototoxicity of aloe-emodin, emodin and rhein
    F Vargas
    Laboratorio de Fotoquimica, Centro de Quimica, Instituto Venezolano de Insvestigaciones Científicas I V I C Venezuela
    Pharmazie 57:399-404. 2002
    ..In summary, this anthraquinone series is phototoxic in vitro. This behavior can be explained through the involvement of singlet oxygen and stable photoproducts...
  45. ncbi Melanin content of cultured human melanocytes and UV-induced cytotoxicity
    S M De Leeuw
    Department of Dermatology, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The Netherlands
    J Photochem Photobiol B 61:106-13. 2001
    ..Our results suggest a protective effect of melanin for UVB and indicate the importance of the measurements of melanin content and composition when different parameters of UV-induced damage are studied in melanin producing cells...
  46. ncbi In vitro studies on the photobiological properties of aloe emodin and aloin A
    Wayne G Wamer
    Center for Food Safety and Applied Nutrition, U S Food and Drug Administration, College Park, MD 20740, USA
    Free Radic Biol Med 34:233-42. 2003
    ..Therefore, generation of reactive oxygen species and oxidative damage after irradiation of aloin A is unlikely. Although aloin A was not directly photocytotoxic, we found that human skin fibroblasts can metabolize aloin A to aloe emodin...
  47. ncbi Topical rose bengal: pre-clinical evaluation of pharmacokinetics and safety
    Eric Wachter
    Provectus Pharmaceuticals, Inc, Knoxville, Tennessee 37931, USA
    Lasers Surg Med 32:101-10. 2003
    ..Rose bengal (RB) is a potent photosensitizer that has largely been overlooked as a potential photodynamic therapy (PDT) agent. In this study, the feasibility of topical delivery of RB to the epidermis has been evaluated...
  48. ncbi 4-Hydroxymethyl- and 4-methoxymethylfuro[2,3-h]quinolin-2(1H)-ones: synthesis and biological properties
    Adriana Chilin
    Department of Pharmaceutical Sciences, University of Padova, Via Francesco Marzolo 5, I 35131, Padova, Italy
    Bioorg Med Chem 11:1311-8. 2003
    ..For all these features, HOFQ and the other analogues appeared very promising photochemotherapeutic agents, whose mechanism of action will be further investigated...
  49. ncbi Reliability of phototoxic tests of fluoroquinolones in vitro
    Ting Zhang
    State Key Laboratory of Drug Research, Shanghai Institue of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Acta Pharmacol Sin 24:453-9. 2003
    ..To make sure the reliability of phototoxic tests in vitro by comparing the phototoxic potential of 4 fluoroquinolones (FQ)...
  50. ncbi An assessment of the phototoxic hazard of a personal product ingredient using in vitro assays
    P A Jones
    Safety and Environmental Assurance Centre, Unilever Colworth, MK44 1LQ, Sharnbrook, Bedfordshire, UK
    Toxicol In Vitro 17:471-80. 2003
    ..This report illustrates the value in a step-wise strategy of the use of human skin models to help interpret the results of other in vitro phototoxicity assays...
  51. ncbi [Epidemiology of contact dermatitis: prevalence of sensitization to different allergens and associated factors]
    Ma T Bordel-Gómez
    Servicio de Dermatologia, Complejo Asistencial de Zamora, Zamora, Espana
    Actas Dermosifiliogr 101:59-75. 2010
    ..In clinical practice, contact dermatitis is a relatively common skin complaint, whose prevalence has increased in recent years. Study by patch testing is essential for diagnosis of contact sensitization...
  52. ncbi [Histopathology of photodermatoses]
    M Megahed
    Klinik für Dermatologie und Allergologie, Universitätsklinikum der RWTH Aachen, Pauwels Strasse 30, 52057 Aachen, Germany
    Hautarzt 57:1083-8. 2006
    ..hydroa vacciniforme, solar urticaria, actinic prurigo, acute actinic dermatosis, solar dermatosis, phototoxic dermatitis and photoallergic dermatitis...
  53. doi In vitro phototoxic potential and photochemical properties of imidazopyridine derivative: a novel 5-HT4 partial agonist
    Satomi Onoue
    Worldwide Pharmaceutical Sciences, Pfizer Global Research and Development PGRD, Nagoya Laboratories, Pfizer Japan, Inc, 5 2 Taketoyo, Aichi 470 2393, Japan
    J Pharm Sci 97:4307-18. 2008
    ..of fatty acid and genetic damage after DNA-binding, which are considered as causative agents for phototoxic dermatitis. Interestingly, both photodegradation and lipoperoxidation were dramatically attenuated by the addition of ..
  54. ncbi Contact allergy to food
    Ronald R Brancaccio
    Ronald O Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA
    Dermatol Ther 17:302-13. 2004
    ..The causes of each of these are reviewed and an approach to the diagnosis and management of contact allergy to foods, spices, and food additives is formulated...
  55. ncbi Nine case series with phototoxic dermatitis related to Chenopodium album
    H U Ozkol
    Department of Dermatology, Van Research and Training Hospital, Van, Turkey
    Hum Exp Toxicol 31:964-8. 2012
    ..Each was exposed to sunlight after eating selemez (the vernacular name of C. album L. ssp. album). The plant samples analyzed by an expert botanist were described as C. album L. ssp. album belonging to Chenopodiacea family...
  56. ncbi Regarding the 'Phytophotodermatitis caused by contact with a fig tree (Ficus carica)' case report, and response
    Tony E J Fitchett
    N Z Med J 120:U2719; author reply U2719. 2007
  57. doi Photosensitivity: a possible cause for Wells' syndrome?
    Yung Chien Kwah
    National Skin Centre, Singapore
    Photodermatol Photoimmunol Photomed 24:52-4. 2008
    ..Wells' syndrome is a rare inflammatory dermatitis. To date, the cause is unknown but it has been associated with a variety of triggers. We present a case of Wells' syndrome with coexisting photosensitivity...
  58. ncbi Drug-induced photoallergic and phototoxic reactions
    Kevin R Stein
    New York Medical College, Department of Dermatology, Metropolitan Hospital Center, New York, NY 10029, USA
    Expert Opin Drug Saf 6:431-43. 2007
    ..The action spectra for most photoallergens and phototoxins lie in the ultraviolet A range. Subtypes of drug-induced photosensitivity include dyschromia, pseudoporphyria, photo onycholysis, and lichenoid and telangiectatic reactions...
  59. ncbi Photobiological studies of new cyclopentene-psoralens
    L Dalla Via
    Department of Pharmaceutical Sciences, University of Padova, Padua, Italy
    Farmaco 53:638-44. 1998
    ..These differences in behaviour between 4 and 7 are probably due to the molecular curvature resulting from the introduction of the cyclopentane ring...
  60. ncbi The cutaneous porphyrias
    H W Lim
    Department of Dermatology, Henry Ford Health System, Detroit, MI 48202, USA
    Semin Cutan Med Surg 18:285-92. 1999
    ....
  61. ncbi Development of a highly sensitive in vitro phototoxicity assay using the SkinEthic reconstructed human epidermis
    F X Bernard
    BIOalternatives, Gençay, France
    Cell Biol Toxicol 16:391-400. 2000
    ..In such conditions, the phototoxicity assay is much more sensitive, so that the model is expected to be of great interest for the detection not only of strong but also of weak phototoxic compounds...
  62. ncbi Photosensitizing activity of hypericin and hypericin acetate after topical application on normal mouse skin
    A Boiy
    Laboratory for Pharmaceutical Biology, Faculty of Pharmaceutical Sciences, K U Leuven, Herestraat 49 bus 824, B 3000 Leuven, Belgium
    Br J Dermatol 158:360-9. 2008
    ..Previously, we have examined the penetration and distribution of hypericin and its acetate ester in the skin of hairless mice after topical application...
  63. ncbi Photobiological properties of nabumetone (4-[6-methoxy-2-naphthalenyl]-2-butanone), a novel non-steroidal anti-inflammatory and analgesic agent
    N Canudas
    Departamento de Quimica, Universidad Simon Bolivar, Caracas, Venezuela
    Pharmazie 55:282-5. 2000
    ..Histidine and thymine were photodegraded by a photosensitized reaction induced by NB. A mechanism involving singlet oxygen, radicals and photoproducts is suggested for the observed photoxicity...
  64. ncbi New antibiotics for community-acquired lower respiratory tract infections: improved activity at a cost?
    P Ball
    Department of Biomedical Sciences, University of St Andrews, Fife, Scotland, St Andrews, UK
    Int J Antimicrob Agents 16:263-72. 2000
    ..All quinolones so far tested appear to prolong the QTc interval, but only sparfloxacin and grepafloxacin caused clinical effects. Nevertheless, caution is required until this effect is fully investigated...
  65. ncbi Comparison of an in vitro cellular phototoxicity model against controlled clinical trials of fluoroquinolone skin phototoxicity
    N J Traynor
    Photobiology Unit, Ninewells Hospital and Medical School, Dundee, UK
    Toxicol In Vitro 14:275-83. 2000
    ....
  66. doi In vitro phototoxicity of dihydropyridine derivatives: a photochemical and photobiological study
    Satomi Onoue
    Worldwide Pharmaceutical Sciences, Pfizer Global Research and Development PGRD, Nagoya Laboratories, Pfizer Japan Inc, 5 2 Taketoyo, Aichi 470 2393, Japan
    Eur J Pharm Sci 33:262-70. 2008
    ..exposure caused significant photodegradation and even peroxidation of fatty acid, which could lead to phototoxic dermatitis. Interestingly, the addition of radical scavengers, especially GSH, MPG and BHA, could attenuate the lipid ..
  67. ncbi Differences in phototoxic potency should be considered when tetracyclines are prescribed during summer-time. A study on doxycycline and lymecycline in human volunteers, using an objective method for recording erythema
    M Bjellerup
    Department of Dermatology, Lund University, General Hospital, Malmo, Sweden
    Br J Dermatol 130:356-60. 1994
    ..We recommend that therapy with doxycycline is avoided during summer-time, and during holidays in a sunny climate...
  68. ncbi Phytophotodermatitis in Rijeka region, Croatia
    Maja Lenkovic
    Department of Dermatovenereology, University Hospital Center Rijeka, Rijeka, Croatia
    Coll Antropol 32:203-5. 2008
    Contact with plants can cause phototoxic or rarely photoallergic reactions. Phototoxic dermatitis (photophytodermatitis) occurs after contact or ingestion of plants containing furocumarins i.e. psoralens and followed by sun exposure...
  69. doi Fragrance material review on 2-methylbutanol
    D McGinty
    Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA
    Food Chem Toxicol 48:S97-101. 2010
    ..2010 for an overall assessment of the safe use of this material and all other branched chain saturated alcohols in fragrances...
  70. doi Fragrance material review on 3-methyl-1-pentanol
    D McGinty
    Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA
    Food Chem Toxicol 48:S93-6. 2010
    ..2010) for an overall assessment of the safe use of this material and all other branched chain saturated alcohols in fragrances...
  71. doi Fragrance material review on 2-ethyl-1-hexanol
    D McGinty
    Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA
    Food Chem Toxicol 48:S115-29. 2010
    ..2010) for an overall assessment of the safe use of this material and all other branched chain saturated alcohols in fragrances...
  72. doi Photooxidation and Phototoxicity of pi-extended squaraines
    Valentina Rapozzi
    Department of Biomedical Science and Technology, University of Udine, Ple Kolbe 4, I 33100 Udine, Italy
    J Med Chem 53:2188-96. 2010
    ..FACS, caspase-3/7 assays and time-lapse microscopy demonstrate that the designed squaraines cause cell death primarily by necrosis...
  73. doi Fragrance material review on 2-methylundecanol
    D McGinty
    Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA
    Food Chem Toxicol 48:S60-2. 2010
    ..2010) for an overall assessment of the safe use of this material and all other branched chain saturated alcohols in fragrances...
  74. doi Acclimation to ultraviolet irradiation affects UV-B sensitivity of Daphnia magna to several environmental toxicants
    Jungkon Kim
    Department of Environmental Health, School of Public Health, Seoul National University, Seoul 110 799, Republic of Korea
    Chemosphere 77:1600-8. 2009
    ....
  75. pmc Structural basis for phototoxicity of the genetically encoded photosensitizer KillerRed
    Sergei Pletnev
    Synchrotron Radiation Research Section, Macromolecular Crystallography Laboratory, National Cancer Institute SAIC Frederick Inc, Frederick, Maryland 21702, USA
    J Biol Chem 284:32028-39. 2009
    ..In particular, Glu(68) and Ser(119), located adjacent to the chromophore, have been assigned as the primary trigger of the reaction chain...
  76. doi Assessment of the phototoxic potential of cosmetic products
    Rajendra K Hans
    Photobiology Division, Industrial Toxicology Research Centre, MG Marg, Lucknow, UP, India
    Food Chem Toxicol 46:1653-8. 2008
    ..The test lipsticks and creams showed absorption in UV/visible range. The study demonstrated synergistic action of cosmetic products and sunlight. Therefore, sunlight exposure should be avoided after the use of photosensitive cosmetics...
  77. ncbi Phytophotodermatitis due to Ficus carica
    Muhterem Polat
    Ankara Numune Education and Research Hospital, 1st Dermatology Department, Ankara, Turkey
    Dermatol Online J 14:9. 2008
    ..Here, we present a case of phytophotodermatitis after contact with fig fruits and leaves. The vesicular dermatitis was primarily located in areas of vitiligo...
  78. doi Population reference intervals for minimal erythemal doses in monochromator phototesting
    Harry Moseley
    The Photobiology Unit, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    Photodermatol Photoimmunol Photomed 25:8-11. 2009
    ..It relies on access to reliable, up-to-date data on the MED in normal individuals. The purpose of this study was to determine MED in normal subjects at different wavebands and compare these with historical controls...
  79. doi Safety studies of pseudo-ceramide SLE66: acute and short-term toxicity
    Osamu Morita
    Global R and D Safety Science, Kao Corporation, Ichikai machi, Haga gun, Tochigi ken, Japan
    Food Chem Toxicol 47:669-73. 2009
    ..The no-observed-adverse-effect level (NOAEL) for systemic toxicity following oral or dermal administration of SLE66 was 1000 mg/kg/day (the highest level tested)...
  80. ncbi Low risk of postinflammatory hyperpigmentation in skin types 4 and 5 after treatment with fractional CO2 laser device
    Kee Lee Tan
    Rejuvenate Cosmetic and Slimming Clinic, Perth, Australia
    J Drugs Dermatol 7:774-7. 2008
    ..This study assessed the risk of postinflammatory hyperpigmentation (PIH) in subjects with skin types 4 and 5 treated once with a specific protocol of treatment using a fractional CO2 laser...
  81. doi Quantitative determination of the reduction of phototoxicity and photobleaching by controlled light exposure microscopy
    R A Hoebe
    Centre for Microscopy Research CMO, Department of Cell Biology and Histology, Academic Medical Centre, Amsterdam, The Netherlands
    J Microsc 231:9-20. 2008
    ..Here, we introduce the CLEM factor as a quantitative measure of reduction in phototoxicity and photobleaching. Finally, we give a guideline to optimize the effect of CLEM without compromising image quality...
  82. ncbi Contact allergy to 8-methoxypsoralen
    H Korffmacher
    Department of Internal Medicine, Ruhr University Bochum, Germany
    Contact Dermatitis 30:283-5. 1994
    ..PUVA therapy caused acute aggravation of the eczema. Patch testing demonstrated Type IV sensitization to 8-methoxypsoralen in Meladinine solution...
  83. doi Photopatch tests: an Italian multicentre study from 2004 to 2006
    Paolo Daniele Pigatto
    Department of Technology for Health, IRCCS, Galeazzi Dermatological Clinic, University of Milan, Via Galeazzi 4, 20161 Milan, Italy
    Contact Dermatitis 59:103-8. 2008
    ..Evaluation of possible photoallergic contact dermatitis in at-risk populations is often not undertaken, and an agreed methodology for investigation is uncommonly used...
  84. ncbi Intralaboratory validation of alternative endpoints in the murine local lymph node assay for the identification of contact allergic potential: primary ear skin irritation and ear-draining lymph node hyperplasia induced by topical chemicals
    P Ulrich
    PCS Genetic and Experimental Toxicology, Novartis Pharma AG, Basel, Switzerland
    Arch Toxicol 74:733-44. 2001
    ....
  85. ncbi Photosensitivity due to drugs
    James Ferguson
    Photobiology Unit, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland
    Photodermatol Photoimmunol Photomed 18:262-9. 2002
  86. ncbi [Current issues in photodermatitis]
    L Meunier
    Service de Dermatologie, CHU de Montpellier, Hôpital Saint Charles, 300 rue A Broussonet, 34295 Montpellier, France
    Therapie 57:257. 2002
  87. ncbi The human epidermis models EpiSkin, SkinEthic and EpiDerm: an evaluation of morphology and their suitability for testing phototoxicity, irritancy, corrosivity, and substance transport
    Frank Netzlaff
    Saarland University, Saarbrucken, Germany
    Eur J Pharm Biopharm 60:167-78. 2005
    ..Further adaptation of the models to the human epidermis, especially concerning the barrier function, therefore remains an important challenge in this area of research...
  88. ncbi Assessment of the phototoxicity of weathered Alaska North Slope crude oil to juvenile pink salmon
    Mace G Barron
    P E A K Research, 1130 Avon Lane, Longmont, CO 80501, United States
    Chemosphere 60:105-10. 2005
    ..The results of this study suggest that pink salmon may be at less risk from photoenhanced toxicity compared to the translucent early-life stages of several other Alaska species...
  89. ncbi Effects of topical petrolatum and salicylic acid upon skin photoreaction to UVA
    Bahar Birgin
    Department of Dermatology, University of Dokuz Eylul, Faculty of Medicine, 35340 Izmir, Turkey
    Eur J Dermatol 15:156-8. 2005
    ..The application of petrolatum and salicylic acid in petrolatum just before PUVA therapy is not recommended because of their blocking effects...
  90. ncbi Fragrance material review on cinnamaldehyde
    J Cocchiara
    Research Institute for Fragrance Materials, Inc, 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA
    Food Chem Toxicol 43:867-923. 2005
    ..A toxicologic and dermatologic review of cinnamaldehyde when used as a fragrance ingredient is presented...
  91. ncbi Wrinkles - biological and immunological features
    Sophie Bosset
    INSERM U 503, Université Claude Bernard et Hospices Civils de Lyon, France
    Eur J Dermatol 12:XXI-XXII. 2002
  92. ncbi Evaluation of phototoxic and photoallergic potentials of 13 compounds by different in vitro and in vivo methods
    Norbert J Neumann
    Hautklinik, Heinrich Heine Universitat, Moorenstrasse 5, 40225 Dusseldorf, Germany
    J Photochem Photobiol B 79:25-34. 2005
    ..As long as no in vitro model for photoallergy is available, the UV-IMDS should be considered to evaluate photoallergic properties of a supposed photoreactive agent...
  93. ncbi Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.) 1. Berberine
    J J Inbaraj
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Chem Res Toxicol 14:1529-34. 2001
    ..These findings suggest that exposure to sunlight or artificial light sources emitting UVA should be avoided when topical preparations derived from Goldenseal or containing berberine are used...
  94. ncbi Photochemistry and in vitro phototoxicity studies of levomepromazine (methotrimeprazine), a phototoxic neuroleptic drug
    F Vargas
    Laboratorio de Fotoquimica, Centro de Quimica, Instituto Venezolano de Investigaciones Cientificas I V I C, Caracas, Venezuela
    Pharmazie 58:315-9. 2003
    ..1 shows a photohemolytic effect on human erythrocytes and photoinducers lipid peroxidation...
  95. ncbi [Adverse drug effects and interactions. What is the current thinking about the use of St. John's wort?]
    Andreas Johne
    Institut für Klinische Pharmakologie Universitätsklinikum Charité Humboldt Universität zu Berlin Schumannstr, 20 21 D 10098 Berlin
    Pharm Unserer Zeit 32:242-6. 2003
  96. ncbi Optical recording of action potentials with second-harmonic generation microscopy
    Daniel A Dombeck
    School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA
    J Neurosci 24:999-1003. 2004
    ....
  97. ncbi Amiodarone-induced peri-oral photosensitivity
    N Shah
    Department of Oral Surgery, Northwick Park Hospital, Middlesex, UK
    J Oral Pathol Med 33:56-8. 2004
    ..His peri-oral lesions rapidly resolved, and there has been no further recurrence. A brief review on photosensitivity and the underlying mechanisms are discussed...
  98. ncbi Photodegradation pathways and the in vitro phototoxicity of pyrazinamide, a phototoxic antitubercular drug
    Franklin Vargas
    Laboratorio de Fotoquimica, Centro de Quimica, Instituto Venezolano de Investigaciones Cientificas I V I C, Apartado 21827, Caracas 1020 A, Venezuela
    J Photochem Photobiol B 72:87-94. 2003
    ..We have also determined the relative efficiencies for the formation of single strand breaks after the irradiation of pBR322 DNA and pyrazinamide, which was also reduced in the presence of GSH...
  99. ncbi [Phototoxicity studies of pazufloxacin mesilate, a novel parenteral quinolone antimicrobial agent--in vitro and in vivo studies]
    Mineko Nagasawa
    Research Laboratories, Toyama Chemical Co, Ltd, 2 4 1 Shimookui, Toyama 930 8508, Japan
    Jpn J Antibiot 55:259-69. 2002
    ..Therefore, photosensitive potency of PZFX mesilate might be less than that of other quinolones...
  100. ncbi Phototoxic reaction and porphyrin fluorescence in skin after topical application of methyl aminolaevulinate
    E Angell-Petersen
    Department of Surgical Oncology, The Norwegian Radium Hospital, N 0310 Oslo, Norway
    Br J Dermatol 156:301-7. 2007
    ..Photodynamic therapy using topical methyl aminolaevulinate (MAL) is a new treatment modality for skin disorders. MAL is metabolized into endogenous porphyrins, which act as photosensitizers when illuminated...
  101. ncbi Role of flavonoids in controlling the phototoxicity of Hypericum perforatum extracts
    K P Wilhelm
    proDERM Institute for Applied Dermatological Research GmbH, Schenefeld/Hamburg, Germany
    Phytomedicine 8:306-9. 2001
    ..Among the tested flavonoids quercitrin was found to be cytotoxic, while rutin unexpectedly demonstrated phototoxicity whereas quercitrin was effective to control the phototoxic activity of Hypericum perforatum extracts...