lichen planus

Summary

Summary: An inflammatory, pruritic disease of the skin and mucous membranes, which can be either generalized or localized. It is characterized by distinctive purplish, flat-topped papules having a predilection for the trunk and flexor surfaces. The lesions may be discrete or coalesce to form plaques. Histologically, there is a "saw-tooth" pattern of epidermal hyperplasia and vacuolar alteration of the basal layer of the epidermis along with an intense upper dermal inflammatory infiltrate composed predominantly of T-cells. Etiology is unknown.

Top Publications

  1. ncbi Mucosal vulval lichen planus: outcome, clinical and laboratory features
    G Kirtschig
    Department of Dermatology, University Hospital Vrije Universiteit, De Boelelaan 1117, Amsterdam, The Netherlands
    J Eur Acad Dermatol Venereol 19:301-7. 2005
  2. ncbi Prevalence of vulval lichen planus in a cohort of women with oral lichen planus: an interdisciplinary study
    P Belfiore
    Mother and Child Department, Gynaecology and Obstetrics Institute, Palermo, Italy
    Br J Dermatol 155:994-8. 2006
  3. ncbi Lichen planus patients and stressful events
    L Manolache
    Cetatea Histria Polyclinic, Bucharest, Romania
    J Eur Acad Dermatol Venereol 22:437-41. 2008
  4. pmc The incidence of molluscum contagiosum, scabies and lichen planus
    R S Pannell
    Birmingham Research Unit of the Royal College of General Practitioners, Birmingham, UK
    Epidemiol Infect 133:985-91. 2005
  5. ncbi Vulval lichen sclerosus and lichen planus
    Tess McPherson
    Department of Dermatology, Churchill Hospital, Oxford, UK
    Dermatol Ther 23:523-32. 2010
  6. ncbi Status of free-radical oxidation and proliferation processes in patients with atopic dermatitis and lichen planus
    S G Sapuntsova
    Department of Dermatology, Central Research Laboratory, Far Eastern State Medical University, Ministry of Health Care and Social Development of the Russian Federation, Khabarovsk, Russia
    Bull Exp Biol Med 150:690-2. 2011
  7. ncbi Childhood lichen planus pemphigoides: a case report and review of the literature
    Daniela M Cohen
    Pediatric Dermatology Unit, Schneider Children s Medical Center, Petah Tiqva, Israel
    Pediatr Dermatol 26:569-74. 2009
  8. ncbi Lichen planus-like eruptions: an emerging side effect of tumor necrosis factor-alpha antagonists
    Adam Asarch
    Department of Dermatology, Tufts Medical Center, 800 Washington St 114, Boston, MA 02111, USA
    J Am Acad Dermatol 61:104-11. 2009
  9. ncbi Detection of human papillomavirus in oral squamous cell carcinoma, leukoplakia and lichen planus in Thai patients
    Siribang on P Khovidhunkit
    Department of Hospital Dentistry, Faculty of Dentistry, Mahidol University, Bangkok, Thailand
    Asian Pac J Cancer Prev 9:771-5. 2008
  10. ncbi Lichen planus and dyslipidaemia: a case-control study
    J Dreiher
    Hospitals Division, Clalit Health Services, Tel Aviv, Israel
    Br J Dermatol 161:626-9. 2009

Detail Information

Publications266 found, 100 shown here

  1. ncbi Mucosal vulval lichen planus: outcome, clinical and laboratory features
    G Kirtschig
    Department of Dermatology, University Hospital Vrije Universiteit, De Boelelaan 1117, Amsterdam, The Netherlands
    J Eur Acad Dermatol Venereol 19:301-7. 2005
    Mucosal lichen planus of the vulva is a rare but increasingly recognized condition. It has potentially severe complications such as fusion of the labia and vagina; the risk of developing squamous cell carcinoma (SCC) may be increased...
  2. ncbi Prevalence of vulval lichen planus in a cohort of women with oral lichen planus: an interdisciplinary study
    P Belfiore
    Mother and Child Department, Gynaecology and Obstetrics Institute, Palermo, Italy
    Br J Dermatol 155:994-8. 2006
    b>Lichen planus (LP) is a mucocutaneous inflammatory dermatosis that frequently involves the oral and genital mucosae...
  3. ncbi Lichen planus patients and stressful events
    L Manolache
    Cetatea Histria Polyclinic, Bucharest, Romania
    J Eur Acad Dermatol Venereol 22:437-41. 2008
    To evaluate the possible role of stress before the onset/extension of lichen planus.
  4. pmc The incidence of molluscum contagiosum, scabies and lichen planus
    R S Pannell
    Birmingham Research Unit of the Royal College of General Practitioners, Birmingham, UK
    Epidemiol Infect 133:985-91. 2005
    We aimed to describe the incidence of new episodes of molluscum contagiosum, scabies and lichen planus presenting to general practitioners in England and Wales...
  5. ncbi Vulval lichen sclerosus and lichen planus
    Tess McPherson
    Department of Dermatology, Churchill Hospital, Oxford, UK
    Dermatol Ther 23:523-32. 2010
    Lichen sclerosus (LS) and lichen planus (LP) are both immunologically mediated diseases with a preference for the genitalia...
  6. ncbi Status of free-radical oxidation and proliferation processes in patients with atopic dermatitis and lichen planus
    S G Sapuntsova
    Department of Dermatology, Central Research Laboratory, Far Eastern State Medical University, Ministry of Health Care and Social Development of the Russian Federation, Khabarovsk, Russia
    Bull Exp Biol Med 150:690-2. 2011
    ..free radicals (by chemiluminescence method) in skin biopsy specimens from patients with atopic dermatitis and lichen planus. The index of Ki-67-positive nuclei significantly (p<0.05) increased to 28.40±2...
  7. ncbi Childhood lichen planus pemphigoides: a case report and review of the literature
    Daniela M Cohen
    Pediatric Dermatology Unit, Schneider Children s Medical Center, Petah Tiqva, Israel
    Pediatr Dermatol 26:569-74. 2009
    b>Lichen planus pemphigoides is a rare autoimmune blistering disease that is characterized by evolution of vesico-bullous skin lesions in patients with active lichen planus...
  8. ncbi Lichen planus-like eruptions: an emerging side effect of tumor necrosis factor-alpha antagonists
    Adam Asarch
    Department of Dermatology, Tufts Medical Center, 800 Washington St 114, Boston, MA 02111, USA
    J Am Acad Dermatol 61:104-11. 2009
    ..We present two cases of lichen planus-like eruptions after infliximab and adalimumab therapy for psoriasis, and review the literature on this ..
  9. ncbi Detection of human papillomavirus in oral squamous cell carcinoma, leukoplakia and lichen planus in Thai patients
    Siribang on P Khovidhunkit
    Department of Hospital Dentistry, Faculty of Dentistry, Mahidol University, Bangkok, Thailand
    Asian Pac J Cancer Prev 9:771-5. 2008
    ..was to investigate the presence of HPV in Thai patients with oral squamous cell carcinoma, leukoplakia and lichen planus using the polymerase chain reaction (PCR)...
  10. ncbi Lichen planus and dyslipidaemia: a case-control study
    J Dreiher
    Hospitals Division, Clalit Health Services, Tel Aviv, Israel
    Br J Dermatol 161:626-9. 2009
    ..Previous reports have demonstrated an association between psoriasis and dyslipidaemia...
  11. ncbi Development of lichen planus and psoriasis on lesions of vitiligo vulgaris
    H Ujiie
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Clin Exp Dermatol 31:375-7. 2006
    This paper reports a unique case of coexistence of vitiligo vulgaris, lichen planus and psoriasis vulgaris in a 53-year-old man. Five years after the onset of vitiligo, lichen planus developed on his lower lip...
  12. pmc Diagnostic criteria for erosive lichen planus affecting the vulva: an international electronic-Delphi consensus exercise
    R C Simpson
    Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, NG7 2NR, UK
    Br J Dermatol 169:337-43. 2013
    There is no defined set of criteria for diagnosing erosive lichen planus affecting the vulva (ELPV) and there is geographical variation in management.
  13. ncbi Psychological health in patients with genital and oral erosive lichen planus
    E N Lundqvist
    Department of Dermatology and Venereology, University Hospital, Umea, Sweden
    J Eur Acad Dermatol Venereol 20:661-6. 2006
    Erosive lichen planus is a severe, recurrent and recalcitrant disease that affects several mucosal areas, mostly the genital area and the mouth, but also, for example, the oesophagus and perianal area...
  14. ncbi A study on the association with hepatitis B and hepatitis C in 1557 patients with lichen planus
    S Birkenfeld
    Clalit Health Services Siaal Research Center for Family Medicine and Primary Care Department of Epidemiology and Health Services Evaluation, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Eur Acad Dermatol Venereol 25:436-40. 2011
    Previous reports have demonstrated contradicting results on the association between lichen planus and hepatitis.
  15. ncbi Lipid levels in patients with lichen planus: a case-control study
    S Arias-Santiago
    Dermatology Department, San Cecilio University Hospital, School of Medicine, Granada University, Granada, Spain
    J Eur Acad Dermatol Venereol 25:1398-401. 2011
    ..Recently, a case-control study found that lichen planus (LP) was associated with dyslipidaemia in a large series of patients...
  16. ncbi An autoimmune phenotype in vulvar lichen sclerosus and lichen planus: a Th1 response and high levels of microRNA-155
    Annelinde Terlou
    Department of Obstetrics and Gynecology, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Invest Dermatol 132:658-66. 2012
    Vulvar lichen sclerosus and lichen planus are T-cell-mediated chronic skin disorders. Although autoimmunity has been suggested, the exact pathogenesis of these disorders is still unknown...
  17. ncbi Cardiovascular risk factors in patients with lichen planus
    Salvador Arias-Santiago
    Department of Dermatology, San Cecilio University Hospital, Granada, Spain
    Am J Med 124:543-8. 2011
    ..Recently a case-control study found that lichen planus was associated with dyslipidemia in a large series of patients...
  18. ncbi Real-life experience of managing vulval erosive lichen planus: a case-based review and U.K. multicentre case note audit
    R C Simpson
    Centre of Evidence Based Dermatology, University of Nottingham, King s Meadow Campus, Lenton Lane, Nottingham NG7 2NR, UK
    Br J Dermatol 167:85-91. 2012
    There is a lack of published evidence for treatment and outcome measures for vulval erosive lichen planus (ELPV).
  19. ncbi Lichen planus pemphigoides: a case report and review of the literature
    Mandy S Harting
    Department of Dermatology, Baylor College of Medicine, Houston, Texas, USA
    Dermatol Online J 12:10. 2006
  20. ncbi Erosive oral lichen planus with genital lesions: the vulvovaginal-gingival syndrome and the peno-gingival syndrome
    Roy S Rogers
    Department of Dermatology, Mayo Clinic, 200 First Street SW Rochester, MN 55905 0001, USA
    Dermatol Clin 21:91-8, vi-vii. 2003
    b>Lichen planus is an inflammatory mucocutaneous disorder that may involve mucosal surfaces, such as the oral, genital, and other mucosae, and the skin including the scalp and the nails...
  21. ncbi Laugier-Hunziker syndrome associated with actinic lichen planus
    S Aytekin
    J Eur Acad Dermatol Venereol 18:221-3. 2004
  22. ncbi Lipid peroxidation and antioxidant status in lichen planus
    E Sezer
    Department of Dermatology, Gaziosmanpasa University School of Medicine, Tokat, Turkey
    Clin Exp Dermatol 32:430-4. 2007
    b>Lichen planus (LP) is an inflammatory skin disease of unknown aetiology. Recently, increased oxidative stress has been implicated in the pathogenesis of various skin diseases such as atopic dermatitis, psoriasis vulgaris and vitiligo.
  23. ncbi A case of paraneoplastic pemphigus associated with Castleman's disease presenting as erosive lichen planus
    H L Tey
    National Skin Centre, Singapore
    Clin Exp Dermatol 34:e754-6. 2009
    ..We present a patient who had been diagnosed and treated for recalcitrant erosive mucocutaneous lichen planus for 3 years with little success...
  24. ncbi Lichen planus in the lines of Blaschko
    Christina Kabbash
    Department of Dermatology, St Luke s Roosevelt Hospital Center, New York, New York 10025, USA
    Pediatr Dermatol 19:541-5. 2002
    ..A biopsy specimen demonstrated the typical histology of lichen planus (LP). There have been fewer than 20 reported cases of childhood linear LP...
  25. ncbi Lichen planus pigmentosus-inversus
    L Pock
    Department of Dermatology and Venerology, Charles University 2nd Medical School, Motol University Hospital, Prague, Czech Republic
    J Eur Acad Dermatol Venereol 15:452-4. 2001
    We examined seven patients with lichen planus pigmentosus (LPP) clinically and microscopically. Clinically, all patients had a striking predominance of lesions in an intertriginous location, with most of them in the axillae...
  26. ncbi Hepatitis C virus infection and lichen planus: a systematic review with meta-analysis
    G Lodi
    Unita di Medicina e Patologia Orale, Dipartimento di Medicina, Chirurgia e Odontoiatria, Universita degli Studi di Milano, Italy
    Oral Dis 16:601-12. 2010
    ..manifestations including mixed cryoglubulinemia, non-Hodgkin lymphoma, diabetes, porphyria cutanea tarda and lichen planus. The aims of this study were to conduct a systematic review and a meta-analysis on the prevalence of HCV in ..
  27. ncbi HLA-DRB1*0101 is associated with the genetic susceptibility to develop lichen planus in the Mexican Mestizo population
    P Luis-Montoya
    Department of Dermatology, Hospital General Dr Manuel Gea Gonzalez, Mexico D F, Mexico
    Arch Dermatol Res 299:405-7. 2007
    The etiology of lichen planus (LP) is still unknown and previous studies have found an association between LP and HLA-DR1, DR2, DR3, DR9 and DR10 in different populations...
  28. ncbi A study of 124 Indian patients with lichen planus pigmentosus
    A J Kanwar
    Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Clin Exp Dermatol 28:481-5. 2003
    b>Lichen planus pigmentosus is a fairly common disorder of pigmentation in Indians, but reports comprising a sizeable number of patients are lacking in the literature...
  29. ncbi Ulcerative lichen planus associated with Sjögren's syndrome
    Hiromi Tsuboi
    Department of Dermatology, Kitasato University School of Medicine, Sagamihara, Japan
    J Dermatol 34:131-4. 2007
    Ulcerative lichen planus is a rare variant of lichen planus that is characterized by ulcerations of the feet and toes that are accompanied by toenail loss...
  30. ncbi Plaque psoriasis vs. atopic dermatitis and lichen planus: a comparison for lesional T-cell subsets, epidermal proliferation and differentiation
    H J Bovenschen
    Department of Dermatology, University Medical Center St Radboud, Nijmegen, René Descartes dreef 1, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Br J Dermatol 153:72-8. 2005
    ..Interestingly, comparative analyses of the disease-specific composition of the lesional T-cell infiltrate in plaque psoriasis and other inflammatory dermatoses have only sparsely been performed...
  31. ncbi Lichen planus and cicatrizing conjunctivitis: characterization of five cases
    Jennifer E Thorne
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Ophthalmol 136:239-43. 2003
    To report the clinical and immunopathologic features and the response to therapy in a series of six patients with cicatrizing conjunctivitis due to lichen planus.
  32. ncbi Two cases of palmoplantar lichen planus with various clinical features
    Min Ji Kim
    Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea
    J Dermatol 37:985-9. 2010
    Two cases of palmoplantar lichen planus with various clinical features. Palmoplantar lichen planus is a rare, localized variant of lichen planus...
  33. ncbi Lichen planus associated with etanercept
    M Battistella
    Br J Dermatol 158:188-90. 2008
  34. ncbi A case of vulvovaginal gingival lichen planus in association with Good's syndrome
    Karwan A Moutasim
    King s College London Dental Institute at Guy s, King s and St Thomas Hospitals, London, UK
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105:e57-60. 2008
    Vulvovaginal gingival lichen planus (VVG LP) is a distinct variant of LP frequently associated with mucocutaneous scarring and vaginal stricture formation...
  35. ncbi Colocalization of lichen planus and vitiligo associated with selective IgA deficiency
    Ulker Gul
    Second Dermatology Clinic, Ankara Numune Education and Research Hospital, Ankara, Turkey
    Skinmed 6:202-3. 2007
    ..Melanocytes were decreased in number, and in some areas they were absent at the basal layer of epidermis. Clinical and histopathologic diagnosis were consistent with lichen planus and vitiligo (Figure 2).
  36. ncbi Lacrimal canalicular duct scarring in patients with lichen planus
    Naomi K Webber
    St John s Institute of Dermatology, Guy s and St Thomas National Health Service Foundation Trust, Westminster Bridge Road, London SE1 7EH, England
    Arch Dermatol 148:224-7. 2012
    b>Lichen planus (LP) is a mucocutaneous inflammatory disease that affects multiple sites, including the skin, oral cavity, vulva, and vagina and can result in scarring and stricture formation...
  37. ncbi Diagnosis of vulval inflammatory dermatoses: a pathological study with clinical correlation
    Leonard Niamh
    Department of Pathology, 5th Floor Duncan Building, Royal Liverpool University Hospital, L7 8XP, England
    Int J Gynecol Pathol 28:554-8. 2009
    ..recent publications to determine whether these could help to distinguish between lichen sclerosus (LS) and lichen planus (LP)...
  38. ncbi Lichen planus of the larynx
    C E Rennie
    Department of Otolaryngology, St Mary s Hospital, London, UK
    J Laryngol Otol 125:432-5. 2011
    We report an extremely rare case of laryngeal lichen planus.
  39. ncbi HLA antigens in Arabs with lichen planus
    A G White
    Department of Organ Transplantation, Kuwait University
    Clin Exp Dermatol 19:236-7. 1994
    We have HLA typed 50 Arab patients with cutaneous lichen planus who were resident in Kuwait and then compared the antigen incidence with 100 normal controls...
  40. ncbi Lichen planus and lichenoid drug-induced eruption: a histological and immunohistochemical study
    Denise Lage
    Department of Pathology Dermatology, Medical School, UNICAMP, Brazil
    Int J Dermatol 51:1199-205. 2012
    Lichenoid drug eruption (LDE) shares similar features with lichen planus (LP), that could reflect the same pathogenesis. In LP, an autoimmune attack is accepted and cytotoxic T-lymphocytes (CD8+) predominate, especially in late lesions...
  41. ncbi Childhood lichen planus: a report of 23 cases
    A Nanda
    Asad Al Hamad, Dermatology Centre, Al Sabah Hospital, Kuwait
    Pediatr Dermatol 18:1-4. 2001
    b>Lichen planus (LP) in children is a rare entity. We report 23 cases of childhood LP seen over a period of 7 years. Ninety-six percent of the children were of Arab ancestry. There were 52% boys and 48% girls...
  42. ncbi Hepatitis C virus and lichen planus
    Yumiko Nagao
    Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    J Gastroenterol Hepatol 19:1101-13. 2004
    ..Sjögren's syndrome, autoimmune thyroiditis, malignant lymphoma, porphyria cutanea tarda and lichen planus. Although the mechanisms of extrahepatic manifestations remain unclear, it is known that interferon (IFN) ..
  43. ncbi [Blood coagulation parameters in patients with lichen planus]
    Anna Wankiewicz
    Katedra i Klinika Dermatologii AM w Bydgoszczy
    Pol Merkur Lekarski 17:55-7. 2004
    ..study was to evaluate some blood parameters of coagulation process in blood plasma of patients suffering from lichen planus. The study group consisted of 23 patients--14 women and 9 men, aged 33-75 years...
  44. ncbi Variations in presentations of esophageal involvement in lichen planus
    David A Katzka
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 8:777-82. 2010
    b>Lichen planus is a relatively uncommon, presumed autoimmune disease that affects middle-aged patients and is manifested in the skin, nails, and mucous membranes...
  45. ncbi Childhood lichen planus: demographics of a U.S. population
    Kara E Walton
    St Luke s Medical Center, Department of Medicine, Milwaukee, Wisconsin, USA
    Pediatr Dermatol 27:34-8. 2010
    b>Lichen planus is an inflammatory dermatosis of unknown origin that is relatively uncommon in children...
  46. ncbi Lichen planus in childhood: report of 100 cases
    A J Kanwar
    Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Clin Exp Dermatol 35:257-62. 2010
    b>Lichen planus (LP) is uncommon in children, and there have been few large studies on LP in this patient group. Most of the literature on childhood LP has appeared as case reports or isolated case series.
  47. ncbi TT virus detection in oral lichen planus lesions
    E Rodriguez-Inigo
    Fundacion para el Estudio de las Hepatitis Virales, C Guzmán el Bueno, 72, 28015 Madrid, Spain
    J Med Virol 64:183-9. 2001
    Epidemiological studies have demonstrated a correlation between oral lichen planus and different liver diseases...
  48. ncbi Antigen mimicry followed by epitope spreading: a pathogenetic trigger for the clinical morphology of lichen planus and its transition to Graham Lassueur Piccardi Little Syndrome and keratosis lichenoides chronica - Medical hypotheses or reality?
    Georgi Tchernev
    Department of Dermatology, Venereology and Dermatosurgery, MVZ, Kirchheim, Germany
    An Bras Dermatol 84:682-8. 2009
    Literature data analysis, providing an exact explanation of the lichen planus pathogenesis, as well as its transition into other rare forms such as Keratosis lichenoides chronica or Graham Lassueur Piccardi Little Syndrome are scant, or ..
  49. ncbi Nail lichen planus in children: clinical features, response to treatment, and long-term follow-up
    A Tosti
    Department of Dermatology, University of Bologna, Via Massarenti 1, 40138 Bologna, Italy
    Arch Dermatol 137:1027-32. 2001
    To report clinical features, response to treatment, and long-term follow-up of nail lichen planus in children.
  50. ncbi Annular atrophic lichen planus
    Ana Morales-Callaghan
    Department of Dermatology, Clinical Hospital of Valladolid, Valladolid, Spain
    J Am Acad Dermatol 52:906-8. 2005
    We describe a new case of annular atrophic lichen planus. Annular atrophic lichen planus is a rare variant of lichen planus that is clinically characterized by violaceous plaques of annular morphology with central atrophy and ..
  51. ncbi Lichen planus and hepatitis virus infections: causal association?
    Katharina Rübsam
    Clinic and Polyclinic for Dermatology and Allergology, Ludwig Maximilian University of Munich, Germany
    J Dtsch Dermatol Ges 9:464-8. 2011
    The causal association between hepatitis virus infections and lichen planus (LP) remains a matter of controversy. Reliable figures for German patients are still lacking.
  52. ncbi Bilateral keratoconjunctivitis associated with lichen planus
    Michelle K Rhee
    Eye and Ear Institute of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA
    Cornea 23:100-5. 2004
    To describe a case of bilateral keratoconjunctivitis in a patient with lichen planus.
  53. pmc Isolated lichen planus of the conjunctiva
    M Pakravan
    Br J Ophthalmol 90:1325-6. 2006
  54. ncbi Lichen planus-like keratosis of the face: a simulator of melanoma in situ
    Gina Raptoulis
    Skin and Cancer Associates, Plantation, Florida, USA
    Dermatol Surg 33:854-6. 2007
  55. ncbi Recognition and management of vulvar dermatologic conditions: lichen sclerosus, lichen planus, and lichen simplex chronicus
    Katrina Alef Thorstensen
    Dartmouth Hitchcock Medical Center, Department of Obstetrics and Gynecology, 1 Medical Center Drive, Lebanon, NH 03756, USA
    J Midwifery Womens Health 57:260-75. 2012
    Lichen sclerosus, lichen planus, and lichen simplex chronicus are dermatologic conditions that can affect the vulva...
  56. ncbi An open-label pilot study of apremilast for the treatment of moderate to severe lichen planus: a case series
    Joan Paul
    Virginia Clinical Research Inc, Norfolk, Virginia 23507, USA
    J Am Acad Dermatol 68:255-61. 2013
    Current treatments for chronic lichen planus (LP) are often ineffective and may have significant adverse side effects. An alternative safe and effective treatment for recalcitrant LP is needed.
  57. ncbi Potential human papillomavirus reactivation following topical corticosteroid therapy of genital lichen sclerosus and erosive lichen planus
    G von Krogh
    Department of Dermatovenereology, Karolinska Hospital, Stockholm, Sweden
    J Eur Acad Dermatol Venereol 16:130-3. 2002
    ..repeatedly with topical mild-moderate potent corticosteroids at intervals of up to 10 weeks for penile erosive lichen planus, followed by nine clinical outbreaks of typical condylomas that consistently showed the presence of low-risk ..
  58. ncbi Association of oral lichen planus with thyroid disease in a Finnish population: a retrospective case-control study
    Maria Siponen
    Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, and Oulu University Hospital, Oulu, Finland
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 110:319-24. 2010
    The objective of this study was to estimate the association between the history of thyroid disease and the prevalence of oral lichen planus (OLP)/oral lichenoid lesions (OLL).
  59. ncbi Lichen planus in 24 children with review of the literature
    Pilar Luis-Montoya
    Dermatology Department, General Hospital Dr Manuel Gea Gonzalez, Tlalpan, Mexico
    Pediatr Dermatol 22:295-8. 2005
    b>Lichen planus is a disease generally considered uncommon in children...
  60. ncbi Exacerbation of oral erosive lichen planus by combination of interferon and ribavirin therapy for chronic hepatitis C
    Yumiko Nagao
    Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Kurume 830 0011, Japan
    Int J Mol Med 15:237-41. 2005
    Hepatitis C virus (HCV) induces extrahepatic manifestations such as oral lichen planus (OLP) as well as chronic liver diseases...
  61. ncbi Childhood lichen planus: a study of 87 cases
    Sanjeev Handa
    Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India
    Int J Dermatol 41:423-7. 2002
    We undertook this study to analyze the clinical profile of childhood lichen planus (LP) prevailing in north India, and to highlight differences from and similarities with adult LP.
  62. ncbi Expression of RANTES and CCR1 in oral lichen planus and association with mast cell migration
    Z Z Zhao
    School of Dentistry, The University of Queensland, Brisbane, Australia
    J Oral Pathol Med 31:158-62. 2002
    T lymphocytes and mast cells infiltrate the lamina propria in oral lichen planus (OLP). Chemokines and their receptors are involved in T cell and mast cell migration and accumulation during the inflammatory process.
  63. ncbi Secondary syphilis presenting as a lichen planus-like rash
    M B Y Tang
    National Skin Centre, 1 Mandalay Road, Singapore 308205, Singapore
    J Eur Acad Dermatol Venereol 18:185-7. 2004
    We describe a case of secondary syphilis in a 29-year-old man who presented with a severely pruritic lichen planus-like eruption that mimicked a lichenoid drug eruption histologically...
  64. ncbi High prevalence of glucose metabolism disturbance in patients with lichen planus
    Muammer Seyhan
    Inonu University, Medical Faculty, Department of Dermatology, 44069 Malatya, Turkey
    Diabetes Res Clin Pract 77:198-202. 2007
    To establish the prevalence of diabetes mellitus (DM) and insulin resistance in patients with lichen planus (LP), and to examine whether diabetic status showed any relation with the type of LP.
  65. ncbi Hepatitis C virus and lichen planus: a reciprocal association determined by a meta-analysis
    Liu Shengyuan
    Department of Epidemiology and Statistics, School of Public Health, No 157 Xuefu Rd, Harbin 150081, China
    Arch Dermatol 145:1040-7. 2009
    To explore the association between hepatitis C virus (HCV) and lichen planus (LP) by performing a meta-analysis of observational studies of the association...
  66. ncbi Reflectance confocal microscopy criteria of lichen planus-like keratosis
    S Bassoli
    Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy
    J Eur Acad Dermatol Venereol 26:578-90. 2012
    b>Lichen planus-like keratosis (LPLK) may be difficult to differentiate from melanoma and other skin cancers on sun-damaged skin based on clinical and dermoscopic examination...
  67. ncbi Lichen planus in childhood: a report of 17 patients
    A J Kanwar
    Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Pediatr Dermatol 8:288-91. 1991
    b>Lichen planus is a dermatosis of unknown origin with a very limited frequency in children. Over a period of one and a half years we observed 17 cases of childhood lichen planus...
  68. pmc Lichen planus and Hepatitis C: a case-control study
    S Zahra Ghodsi
    Department of Dermatology, Tehran University of Medical Sciences Razi Hospital, Vahdat Islami Square, 11996 Tehran, Iran
    BMC Dermatol 4:6. 2004
    The association of lichen planus with hepatitis C (HCV) has been widely reported in the literature. However, there are wide geographical variations in the reported prevalence of HCV infection in patients with lichen planus...
  69. ncbi Paraneoplastic pemphigus in association with a retroperitoneal Castleman's disease presenting with a lichen planus pemphigoides-like eruption. A case report and review of literature
    C J Hsiao
    Department of Dermatology, National Cheng-Kung University Hospital, 138 Sheng-Li Road, Tainan, Taiwan 704
    Br J Dermatol 144:372-6. 2001
    A 50-year-old man presented with severe mucosal erosions of the lips, oral cavity and perianal area, a lichen planus-like eruption on the trunk and extremities and scaly plaques of the palms and soles...
  70. ncbi Childhood lichen planus: a report of fifty cases
    R Sharma
    Bishen Skin Centre, Aligarh, India
    Pediatr Dermatol 16:345-8. 1999
    b>Lichen planus is an uncommonly encountered dermatosis in children. In the present study of 50 children the limbs were the most common site of involvement (70.0%). A majority of the children (60...
  71. ncbi Oral lesions in patients with lichen planus
    Sanja Persić
    School of Dental Medicine, University of Zagreb, Croatia
    Acta Clin Croat 47:91-6. 2008
    Forty patients with lichen planus admitted to University Department of Dermatology and Venereology, Sestre milosrdnice University Hospital in Zagreb during the 2004-2006 period were assigned to this retrospective study...
  72. ncbi Pathomechanisms of lichen planus autoimmunity elicited by cross-reactive T cells
    Tetsuo Shiohara
    Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan
    Curr Dir Autoimmun 10:206-26. 2008
    b>Lichen planus (LP) is an idiopathic inflammatory disease of the skin and mucous membranes, characterized by an autoimmune attack on the epidermis by skin-infiltrating T cells...
  73. ncbi Efficacy of sulfasalazine in the treatment of generalized lichen planus: randomized double-blinded clinical trial on 52 patients
    M Omidian
    Department of Dermatology, Imam Khomeini Hospital, Jondishapur University of Medical Sciences, Ahvaz, Iran
    J Eur Acad Dermatol Venereol 24:1051-4. 2010
    Oral sulfasalazine has been reported to be effective in patients with idiopathic cutaneous lichen planus (LP).
  74. ncbi Gene expression profiling of lichen planus reflects CXCL9+-mediated inflammation and distinguishes this disease from atopic dermatitis and psoriasis
    Joerg Wenzel
    Department of Dermatology, University of Bonn, Bonn, Germany
    J Invest Dermatol 128:67-78. 2008
    ..On the basis of these results, a new skin pathology-oriented PIQOR microarray was designed. Lichen planus (LP) was chosen as a model disease to evaluate this system...
  75. ncbi Involvement of granzyme B and granulysin in the cytotoxic response in lichen planus
    M Ammar
    Laboratoire d Immunologie, de Génétique et de Pathologie Humaine, Faculte des Sciences, Tunis, Tunisie
    J Cutan Pathol 35:630-4. 2008
    b>Lichen planus is an inflammatory dermatosis involving either skin and/or mucosal epithelial surfaces. A cell-mediated cytotoxicity response is the main suspected mechanism of this dermatosis...
  76. ncbi The association of lichen sclerosus and erosive lichen planus of the vulva with autoimmune disease: a case-control study
    Susan M Cooper
    Department of Dermatology, Churchill Hospital, Oxford, England
    Arch Dermatol 144:1432-5. 2008
    To investigate the prevalence of autoimmune disease and circulating autoantibodies in women with lichen sclerosus (LS) and erosive lichen planus (LP) of the vulva and to compare these with a control population.
  77. ncbi Lichen planus in children: a possible complication of hepatitis B vaccines
    Catherine Limas
    Department of Dermatopathology, Andreas Sygros Hospital, Athens, Greece
    Pediatr Dermatol 19:204-9. 2002
    b>Lichen planus (LP) has been reported as a complication of hepatitis B vaccination in both adults and children. According to published observations, an autoimmune reaction may be triggered by the viral S epitope...
  78. ncbi Lichen planus and hepatitis C virus infection
    R Gimenez-Garcia
    Dermatology Section, Internal Medicine Service, Hospital del Rio Hortega, Valladolid, Spain
    J Eur Acad Dermatol Venereol 17:291-5. 2003
    The association of lichen planus (LP) with liver diseases is well established. The reported prevalence rates of hepatitis C virus (HCV) antibodies in patients with LP tend to appear quite variable.
  79. ncbi Bicanalicular obstruction in lichen planus: a characteristic pattern of disease
    Omar M Durrani
    Moorfields Eye Hospital, London, United Kingdom
    Ophthalmology 115:386-9. 2008
    b>Lichen planus, an idiopathic mucocutaneous inflammatory disease, has only once been reported to cause lacrimal drainage obstruction...
  80. ncbi Oro-genital lichen planus: report of two cases
    Eliana M Minicucci
    Department of Dermatology and Radiotherapy, Botucatu Medical School, Sao Paulo State University, UNESP, SP, Brazil
    Maturitas 59:201-5. 2008
    b>Lichen planus is a common mucocutaneous disease. However, lichen planus with concomitant oral and genital involvement is a rare condition that requires multidisciplinary intervention for appropriate diagnosis...
  81. ncbi Vaginal involvement in genital erosive lichen planus
    Anne Lise Ording Helgesen
    The National Resource Centre for Women s Health, Oslo University Hospital, Norway
    Acta Obstet Gynecol Scand 89:966-70. 2010
    ..Fifty-eight women referred to the clinic in 2003-2009 were diagnosed with genital erosive lichen planus. All patients filled out a questionnaire...
  82. ncbi Adalimumab in the management of cutaneous and oral lichen planus
    Tomas J Chao
    Gardner Dermatology, 2550 Windy Hill Rd, Ste 220, Marietta, GA 30067, USA
    Cutis 84:325-8. 2009
    b>Lichen planus (LP) is a common, chronic, inflammatory dermatosis that may involve the skin as well as oral and genital mucosa...
  83. ncbi Oro-vaginal-vulvar lichen planus: report of two new cases
    Massimo Petruzzi
    Department of Odontostomatology and Surgery, University of Bari, Via Zara 1, 74100 Taranto, Italy
    Maturitas 50:140-50. 2005
    Atrophic-erosive lichen planus with oral and genital involvement is a rare condition and is often difficult to diagnose...
  84. ncbi The vulvovaginal gingival syndrome: a severe subgroup of lichen planus with characteristic clinical features and a novel association with the class II HLA DQB1*0201 allele
    Jane F Setterfield
    St John s Institute of Dermatology, St Thomas Hospital, London SE1 7EH, UK
    J Am Acad Dermatol 55:98-113. 2006
    The vulvovaginal gingival syndrome is an uncommon and severe variant of lichen planus characterized by erosions or desquamation of vulval, vaginal, and gingival mucosae with a predilection for scarring and stricture formation.
  85. ncbi Influence of treatment of erosive lichen planus of the vulva on its prognosis
    Susan M Cooper
    Department of Dermatology, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, England
    Arch Dermatol 142:289-94. 2006
    To record the clinical features, symptomatic response to treatment, and resolution of clinical signs in a large cohort of women with erosive lichen planus of the vulva.
  86. ncbi Expression of matrix metalloproteinases (MMP-2, MMP-3, and MMP-9) and fibronectin in lichen planus
    Kamer Gunduz
    Department of Dermatology, Celal Bayar University
    J Cutan Pathol 33:545-50. 2006
    Keratinocyte damage and lichenoid-interface reaction are the two major pathologic findings in lichen planus (LP)...
  87. ncbi Lichen planus and the vulvovaginal-gingival syndrome
    M A Ramer
    Department of Pathology, The Mount Sinai School of Medicine, New York, NY 10029, USA
    J Periodontol 74:1385-93. 2003
    b>Lichen planus is a dermatologic disease that affects both skin and mucosa. Here we report five cases of lichen planus that presented as the oral component of the vulvovaginal-gingival syndrome...
  88. ncbi Dermoscopic features of plaque psoriasis and lichen planus: new observations
    Francisco Vázquez-López
    Department of Dermatology, Central University Hospital, University of Oviedo, Oviedo, Spain
    Dermatology 207:151-6. 2003
    ..Dermoscopic features of common inflammatory dermatoses are not well studied and previous reports on this topic are limited to the search of vascular features (capillaroscopy)...
  89. ncbi NF-kappaB expression in oral and cutaneous lichen planus
    Amerigo Santoro
    Department of Odontostomatology, University of Brescia, Spedali Civili Brescia, Brescia, Italy
    J Pathol 201:466-72. 2003
    b>Lichen planus (LP) is a chronic inflammatory disorder involving cutaneous and mucosal surfaces, characterized by a T-cell-mediated immune response against epithelial cells, with persistent accumulation of T lymphocytes and epithelial ..
  90. ncbi Analysis of hepatitis C virus (HCV) RNA in the lesions of lichen planus in patients with chronic hepatitis C: detection of anti-genomic- as well as genomic-strand HCV RNAs in lichen planus lesions
    Motoki Kurokawa
    Department of Dermatology, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    J Dermatol Sci 32:65-70. 2003
    Hepatitis C virus (HCV) is a single-strand RNA virus. The association of lichen planus with chronic HCV infection has been reported, as has been cryoglobulinemic purpura, psoriasis, urticaria, and porphyria cutanea tarda...
  91. ncbi Cutaneous lichen planus and squamous cell carcinoma
    G K Patel
    J Eur Acad Dermatol Venereol 17:98-100. 2003
  92. ncbi Heat shock proteins 60 and 70 expression of cutaneous lichen planus: comparison with normal skin and psoriasis vulgaris
    Dilek Bayramgurler
    Department of Dermatology, Kocaeli University, School of Medicine, Izmit, Turkey
    J Cutan Pathol 31:586-94. 2004
    ..b>Lichen planus (LP) is a relatively common papulosquamous dermatosis, and cell-mediated immunity plays an important role in ..
  93. ncbi Treatment of severe lichen planus with mycophenolate mofetil
    Uta Frieling
    Department of Dermatology, University of Munster, Von Esmarch Strasse 58, D 48149 Munster, Germany
    J Am Acad Dermatol 49:1063-6. 2003
    b>Lichen planus (LP) is an inflammatory skin disorder with a wide range of clinical appearances. The treatment of disseminated and especially erosive forms of LP is often difficult and disappointing...
  94. ncbi Narrowband UVB therapy in the treatment of lichen planus
    Hayriye Saricaoglu
    Department of Dermatology, Medical Faculty, University of Uludag, Gorukle, Bursa, Turkey
    Photodermatol Photoimmunol Photomed 19:265-7. 2003
    ..Narrowband UVB (NBUVB) radiation causes less erythema and carcinogenicity with lower cumulative doses than PUVA, while the treatment response remains high. Lichen planus (LP) is a cell-mediated immune response of unknown origin.
  95. ncbi Evaluation of angiogenesis in normal and lichen planus skin by CD34 protein immunohistochemistry: preliminary findings
    Mahmoud R Hussein
    Departments of Pathology, Assuit University Hospitals and Faculty of Medicine, Assuit University, Assuit, Egypt
    Cell Biol Int 31:1292-5. 2007
    ..chronic inflammatory disorders, but whether angiogenesis also occurs in inflammatory skin diseases (such as lichen planus) has yet to be established...
  96. ncbi Two case reports of cutaneous adverse reactions following hepatitis B vaccine: lichen planus and granuloma annulare
    P R Criado
    Dermatology Unit, Allergy Unit, Estadual de Sao Paulo, Brazil
    J Eur Acad Dermatol Venereol 18:603-6. 2004
    ..occurred 3 weeks after the first dose of hepatitis B vaccine in a 16-year-old white girl with the onset of lichen planus lesions on her thighs and abdomen. After the second dose a disseminated lichen planus developed within 2 weeks...
  97. ncbi Lupus erythematosus/lichen planus overlap syndrome with scarring alopecia
    H S Inaloz
    Department of Dermatology, University of Wales College of Medicine, Cardiff, South Wales, UK
    J Eur Acad Dermatol Venereol 15:171-4. 2001
    Lupus erythematosus (LE) and lichen planus (LP) may occur as an overlap syndrome (LE/LP)...
  98. ncbi Lichen planus in hepatitis C virus infection: an early marker that may save lives
    Mojca Maticic
    Clinic of Infectious Diseases and Febrile Illnesses, Ljubljana, University Medical Center, Japljeva 2, 1000 Ljubljana, Slovenia
    Acta Dermatovenerol Alp Pannonica Adriat 16:3-6. 2007
    ..some cutaneous ones such as mixed cryoglobulinemia, porphyria cutanea tarda, leukocytoclastic vasculitis, lichen planus (LP), sicca syndrome, and others...
  99. ncbi Lupus erythematosus and lichen planus overlap syndrome
    Hanna Kim
    Boston University Department of Dermatology, 609 Albany Street, Boston MA 02118, USA
    J Drugs Dermatol 3:311-2. 2004
    A case of lupus erythematosus (LE) and lichen planus (LP) overlap syndrome in a 71-year-old woman is presented. This disease displays characteristics of both LE and LP...
  100. ncbi Congenital becker nevus with lichen planus
    Suruchi Puri
    Department of Dermatology and S T D and Pathology, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India
    Pediatr Dermatol 22:328-30. 2005
    We report an interesting and rare association of congenital Becker nevus with lichen planus occurring in an 11-year-old boy. Both conditions were confirmed histopathologically.
  101. ncbi A case of lichen planus-lupus erythematosus overlap syndrome with eyelid involvement
    U Tursen
    Department of Dermatology, Faculty of Medicine, Mersin University, Turkey
    Eur J Ophthalmol 12:244-6. 2002
    To report a case of lichen planus-lupus erythematosus overlap syndrome with eyelid involvement. Lichen planus and lupus erythematosus infrequently coexist in the same patients. Ocular involvement has rarely been reported for both diseases.

Research Grants20

  1. Short Wavelength UV Sources for Treatment of Psoriasis
    JOSEPH SMART; Fiscal Year: 2006
    ..for psoriasis and possibly other skin diseases including acne vularis, atopic dermatitis, vitiligo, pruritus, lichen planus, pityriasis rosea and early cutaneous T-cell lymphoma...
  2. Inhibitors of Toll-like receptors 7 & 9 for treatment of skin inflammation
    FRANCK BARRAT; Fiscal Year: 2010
    ..dendritic cells in cutaneous lupus and in a series of related cutaneous autoimmune diseases, including lichen planus dermatomyositis, lichen sclerosus and cutaneous GVHD...
  3. Salivary Biomarkers for Oral Cancer in Lichen Planus Patients
    Yi Shing Lisa Cheng; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Lichen Planus (LP) is a chronic, inflammatory--and, so far, incurable--disease of unknown etiology, affecting skin and mucosa of approximately 2% of the population...
  4. STRUCTURE AND REGULATION OF THE CD1 MULTIGENE FAMILY
    PAUL BLEICHER; Fiscal Year: 1992
    ..to the pathogenesis of a large number of inflammatory and malignant diseases such as lupus erythematosus, lichen planus, cutaneous T cell lymphoma, and Histiocytosis X...
  5. Trials to Enhance Elders' Teeth/Oral Health (TEETH)
    Asuman Kiyak; Fiscal Year: 2004
    ..Mortality rates in both groups are similar, and the most common oral lesion - lichen planus - has a similar prevalence in both groups...
  6. T-CELL MECHANISMS OF PATHOLOGY IN DTH & DRUG ERUPTIONS
    Richard Kalish; Fiscal Year: 1992
    ..It is hoped that these studies will lay the groundwork for future study of T-lymphocyte mediated conditions in which the inciting antigen is not known, such as sarcoidosis, lichen planus, and scleroderma.
  7. CHARACTERIZATION AND CULTURE OF HUMAN LANGERHANS CELLS
    Vera Morhenn; Fiscal Year: 1991
    ..Moreover, although their numbers are altered in a variety of skin diseases, e.g. lichen planus, mycosis fungoides, AID, their role (if any) in these disorders is totally obscure...
  8. World Workshop in Oral Medicine IV
    Peter Lockhart; Fiscal Year: 2005
    ..concerning: Group 1: oral infections, (fungal and viral); Group 2: orai mucosal lesions (dysplasia and lichen planus); Group 3: oral, facial pain (neuropathic pain and burning mouth syndrome); Group 4: medically complex ..
  9. MECHANISMS OF CUTANEOUS INJURY IN LUPUS ERYTHEMATOSUS
    Richard Sontheimer; Fiscal Year: 1991
    ..These studies might also yield insight into the pathogenesis of other related inflammatory skin diseases such as lichen planus, dermatomyositis and lichenoid drug eruptions.
  10. Vulvar Disease and Bladder and Bowel Symptoms
    Colleen Kennedy; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  11. MECHANISMS OF CUTANEOUS INJURY IN LUPUS ERYTHEMATOSUS
    Richard Sontheimer; Fiscal Year: 2001
    ....
  12. Surveillance for Hepatocellular Carcinoma among HCV-infected Veterans
    Hashem El Serag; Fiscal Year: 2009
    ..Evaluating the extent and patterns of HCC surveillance is crucial in understanding diffusion (and obstacles) of this practice and in designing interventions to improve the implementation of HCC surveillance. ..
  13. Candida-endothelial interactions under conditions of flow
    Martin Thornhill; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  14. Role of Cystatins in Oral Cancer Metastasis
    Nadarajah Vigneswaran; Fiscal Year: 2007
    ..Insights gained from these studies will be used to design therapeutic strategies for restoring immune competence of OSCC patients to prevent and eradicate OSCC metastasis. [unreadable] [unreadable] [unreadable]..
  15. Tonsil Model of Oral HIV-1 Infection via Breastfeeding
    Diane Shugars; Fiscal Year: 2003
    ....
  16. Gene Expression in Barrett's Esophagus
    Hashem El Serag; Fiscal Year: 2006
    ..We present preliminary data on microarray and RT-PCRanalyses on 5 patients with BE that suggest an overactive Wnt pathway: we have also assembled the essential components of a successful study using microarrays. ..
  17. CD80 binding peptides as therapeutic agents in arthritis
    Mythily Srinivasan; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  18. Oramelts with DGL: Treatment of Minor RAU
    Michael Martin; Fiscal Year: 2004
    ..If these claims are verified in clinical trials, Orahealth Corporation will take the product to market, providing health benefits to the 20% of people who suffer from minor recurrent aphthous ulcers. ..
  19. Visual outcomes & quality of life in CMV retinitis
    Jennifer Thorne; Fiscal Year: 2006
    ..abstract_text> ..