mastocytosis

Summary

Summary: A heterogenous group of disorders characterized by the abnormal increase of MAST CELLS in only the skin (MASTOCYTOSIS, CUTANEOUS), in extracutaneous tissues involving multiple organs (MASTOCYTOSIS, SYSTEMIC), or in solid tumors (MASTOCYTOMAS).

Top Publications

  1. ncbi [Systemic mast cell disease with gastrointestinal symptoms--a diagnostic questionnaire]
    G J Molderings
    Institut fur Pharmakologie und Toxikologie, Universitatsklinikum Bonn
    Dtsch Med Wochenschr 131:2095-100. 2006
  2. ncbi The mast cell in interstitial cystitis: role in pathophysiology and pathogenesis
    Grannum R Sant
    Department of Urology, Tufts University School of Medicine, Boston, Massachusetts, USA
    Urology 69:34-40. 2007
  3. doi Mastocytosis and insect venom allergy: diagnosis, safety and efficacy of venom immunotherapy
    M Niedoszytko
    Department of Allergology, Medical University of Gdansk, Poland
    Allergy 64:1237-45. 2009
  4. pmc Mast cells and mastocytosis
    Dean D Metcalfe
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1881, USA
    Blood 112:946-56. 2008
  5. pmc Apoptosis, mastocytosis, and diminished adipocytokine gene expression accompany reduced epididymal fat mass in long-standing diet-induced obese mice
    Mehmet M Altintas
    Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA
    Lipids Health Dis 10:198. 2011
  6. pmc Mast cells are required for experimental oral allergen-induced diarrhea
    Eric B Brandt
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    J Clin Invest 112:1666-77. 2003
  7. ncbi KIT mutation in mast cells and other bone marrow hematopoietic cell lineages in systemic mast cell disorders: a prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients
    Andres C Garcia-Montero
    Centro de Investigacion del Cancer, Campus Miguel de Unamuno, 37007 Salamanca, Spain
    Blood 108:2366-72. 2006
  8. pmc Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsia
    M M Walker
    Department of Histopathology, Faculty of Medicine, St Mary s Campus, Imperial College, London, UK
    Aliment Pharmacol Ther 29:765-73. 2009
  9. ncbi Mastocytosis: pathology, genetics, and current options for therapy
    Peter Valent
    Department of Internal Medicine I, Medical Univeristy of Vienna, Austria
    Leuk Lymphoma 46:35-48. 2005
  10. ncbi The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations
    Yongsheng Ma
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Blood 99:1741-4. 2002

Research Grants

  1. Oncogenic Kit receptor signaling in vivo
    Peter Besmer; Fiscal Year: 2009
  2. Oncogenic Kit receptor signaling in vivo
    Peter Besmer; Fiscal Year: 2010
  3. A Mouse Model for Human Gastrointestinal Stromal Tumor
    Peter Besmer; Fiscal Year: 2010
  4. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2003
  5. System for Rapid Generation of Aptamers for Transplant Therapies
    KAREN QIAN; Fiscal Year: 2010
  6. GROWTH AND DIFFERENTIATION OF HUMAN MAST CELLS
    ROBERT BRESSLER; Fiscal Year: 1990
  7. Role of Vav and Rac in KIT oncogenesis
    Reuben Kapur; Fiscal Year: 2010
  8. Role of Vav and Rac in KIT oncogenesis
    Reuben Kapur; Fiscal Year: 2009
  9. Role of Vav and Rac in KIT oncogenesis
    Reuben Kapur; Fiscal Year: 2011
  10. HUMAN STRONGYLOIDIASIS: DEVELOPMENT OF A CANINE MODEL
    Gerhard Schad; Fiscal Year: 1991

Detail Information

Publications215 found, 100 shown here

  1. ncbi [Systemic mast cell disease with gastrointestinal symptoms--a diagnostic questionnaire]
    G J Molderings
    Institut fur Pharmakologie und Toxikologie, Universitatsklinikum Bonn
    Dtsch Med Wochenschr 131:2095-100. 2006
    ..This report describes how the diagnosis systemic mast cell disease can be established with a diagnostic questionnaire based on a synopsis of clinical findings relevant to a mast cell mediator activation syndrome...
  2. ncbi The mast cell in interstitial cystitis: role in pathophysiology and pathogenesis
    Grannum R Sant
    Department of Urology, Tufts University School of Medicine, Boston, Massachusetts, USA
    Urology 69:34-40. 2007
    ....
  3. doi Mastocytosis and insect venom allergy: diagnosis, safety and efficacy of venom immunotherapy
    M Niedoszytko
    Department of Allergology, Medical University of Gdansk, Poland
    Allergy 64:1237-45. 2009
    The most important causative factor for anaphylaxis in mastocytosis are insect stings...
  4. pmc Mast cells and mastocytosis
    Dean D Metcalfe
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1881, USA
    Blood 112:946-56. 2008
    ..In hematology, the clinical disease of mastocytosis is characterized by a pathologic increase of mast cells in tissues, often associated with mutations in KIT, the ..
  5. pmc Apoptosis, mastocytosis, and diminished adipocytokine gene expression accompany reduced epididymal fat mass in long-standing diet-induced obese mice
    Mehmet M Altintas
    Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA
    Lipids Health Dis 10:198. 2011
    ..Moreover, gene and/or protein expression of several adipocytokines (leptin, adiponectin, TNF-α, IL-10, IL-6, MCP-1), F4/80, mMCP6, cleaved caspase-3 were determined...
  6. pmc Mast cells are required for experimental oral allergen-induced diarrhea
    Eric B Brandt
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    J Clin Invest 112:1666-77. 2003
    ..restricted, dose-dependent, acute diarrhea associated with increased intestinal permeability, eosinophilia, and mastocytosis. Mice developed limited systemic manifestations of anaphylaxis, even though they developed marked intestinal ..
  7. ncbi KIT mutation in mast cells and other bone marrow hematopoietic cell lineages in systemic mast cell disorders: a prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients
    Andres C Garcia-Montero
    Centro de Investigacion del Cancer, Campus Miguel de Unamuno, 37007 Salamanca, Spain
    Blood 108:2366-72. 2006
    ..of KIT mutations in different compartments of bone marrow (BM) hematopoietic cells of individuals with systemic mastocytosis (SM), and its different diagnostic categories, remains unknown...
  8. pmc Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsia
    M M Walker
    Department of Histopathology, Faculty of Medicine, St Mary s Campus, Imperial College, London, UK
    Aliment Pharmacol Ther 29:765-73. 2009
    ..Irritable bowel syndrome (IBS) and functional dyspepsia (FD) are common functional disorders without defined pathology. Mast cells and eosinophils interact with T lymphocytes and may alter enteric nerve and smooth muscle function...
  9. ncbi Mastocytosis: pathology, genetics, and current options for therapy
    Peter Valent
    Department of Internal Medicine I, Medical Univeristy of Vienna, Austria
    Leuk Lymphoma 46:35-48. 2005
    ..Symptoms in mastocytosis result from MC-derived mediators and, less frequently, from destructive infiltration of MCs...
  10. ncbi The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations
    Yongsheng Ma
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Blood 99:1741-4. 2002
    ..of c-KIT causing spontaneous activation of the KIT receptor kinase are associated with sporadic adult human mastocytosis (SAHM) and with human gastrointestinal stromal tumors...
  11. pmc Phenotypic and genotypic characteristics of mastocytosis according to the age of onset
    Fanny Lanternier
    Universite Paris V, Service de Maladies Infectieuses et Tropicales, centre de référence des mastocytoses, Hopital Necker Enfants Malades, Centre d Infectiologie Necker Pasteur, Paris, France
    PLoS ONE 3:e1906. 2008
    Adult's mastocytosis is usually associated with persistent systemic involvement and c-kit 816 mutation, while pediatrics disease is mostly limited to the skin and often resolves spontaneously...
  12. ncbi CD203c is overexpressed on neoplastic mast cells in systemic mastocytosis and is upregulated upon IgE receptor cross-linking
    A W Hauswirth
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria
    Int J Immunopathol Pharmacol 21:797-806. 2008
    ..expression of CD203c on normal mast cells (MC)and bone marrow (bm) MC derived from 85 patients with systemic mastocytosis (SM), including cases with indolent SM (ISM, n=72), SM with associated clonal hematologic non-MC-lineage ..
  13. ncbi Classes of c-KIT activating mutations: proposed mechanisms of action and implications for disease classification and therapy
    B J Longley
    Department of Dermatology and Pathology, Columbia University, 630 West 168th Street, VC-15-202, New York, NY 10031, USA
    Leuk Res 25:571-6. 2001
    Mutations causing constitutive activation of KIT have been shown to be causative in some forms of mastocytosis, and several types of mutations have been associated with myeloproliferative disorders (MPDs), acute myelogenous leukemia (AML),..
  14. ncbi Standards and standardization in mastocytosis: consensus statements on diagnostics, treatment recommendations and response criteria
    P Valent
    Department of Internal Medicine I, Division of Haematology and Haemostaseology, Medical University of Vienna, Vienna, Austria
    Eur J Clin Invest 37:435-53. 2007
    Although a classification for mastocytosis and diagnostic criteria are available, there remains a need to define standards for the application of diagnostic tests, clinical evaluations, and treatment responses...
  15. ncbi Mastocytosis: molecular mechanisms and clinical disease heterogeneity
    D D Metcalfe
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg. 10, Rm. 11C205, 10 Center Drive MSC 1881, Bethesda, MD 20892-1881, USA
    Leuk Res 25:577-82. 2001
    Systemic mastocytosis has one unifying feature: an unexplained and pathologic increase in mast cells in specific tissues...
  16. ncbi Enhanced protection against Heligmosomoides polygyrus in IL-2 receptor β-chain overexpressed transgenic mice with intestinal mastocytosis
    Masahiro Morimoto
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Japan
    J Vet Med Sci 73:849-51. 2011
    ..These mice also exhibit intestinal mastocytosis. Helminth infection induces various immune responses, such as mast cells, goblet cells, eosinophils and IgE, ..
  17. ncbi Pathogenesis, classification and treatment of mastocytosis: state of the art in 2010 and future perspectives
    Michel Arock
    Laboratoire de Biologie et Pharmacologie Appliquée, CNRS UMR 8113, Ecole Normale Superieure de Cachan, 61, Ave du Président Wilson, 94235 Cachan Cedex, France
    Expert Rev Hematol 3:497-516. 2010
    b>Mastocytosis is a myeloid neoplasm characterized by abnormal accumulation and frequent activation of mast cells (MCs) in various organs. Organ systems typically involved are the bone marrow, skin, liver and gastrointestinal tract...
  18. doi Mastocytosis: an unusual clonal disorder of bone marrow-derived hematopoietic progenitor cells
    Hans Peter Horny
    Institute of Pathology, D 91522 Ansbach, Germany
    Am J Clin Pathol 132:438-47. 2009
    b>Mastocytosis, an unusual disorder of bone marrow-derived, clonally transformed hematopoietic progenitor cells, exhibits a broad spectrum of clinical and morphologic features ranging from a self-limiting benign disorder (ie, juvenile ..
  19. ncbi Mastocytosis: current concepts in diagnosis and treatment
    L Escribano
    Hospital Ramon y Cajal, Unidad de Mastocitosis, Carretera de Colmenar Km 9 1, Madrid 28034, Spain
    Ann Hematol 81:677-90. 2002
    b>Mastocytosis consists of a group of disorders characterized by a pathologic increase in mast cells in tissues including skin, bone marrow, liver, spleen, and lymph nodes. Mastocytosis is a rare disease...
  20. pmc Pulmonary mastocytosis and enhanced lung inflammation in mice heterozygous null for the Foxf1 gene
    Tanya V Kalin
    Division of Pulmonary Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 39:390-9. 2008
    ..Foxf1 haploinsufficiency caused pulmonary mastocytosis and enhanced pulmonary inflammation after chemically induced or allergen-mediated lung injury, indicating an ..
  21. ncbi Localized eosinophilic ileitis with mastocytosis successfully treated with oral budesonide
    C Lombardi
    Allergy and Respiratory Diseases, Department of Internal Medicine, Genoa, Italy
    Allergy 62:1343-5. 2007
  22. ncbi Ichthyosis congenita type IV: a new case resembling diffuse cutaneous mastocytosis
    A Brusasco
    Centre for Inherited Cutaneous Diseases, IRCCS, Ospedale Maggiore, University of Milan, Italy
    Br J Dermatol 136:377-9. 1997
    ..was further complicated by hypereosinophilia and a strongly positive Darier's sign suggesting diffuse cutaneous mastocytosis. The diagnosis was provided only by electron microscopy, which showed the pathognomonic markers of ichthyosis ..
  23. pmc The alpha form of human tryptase is the predominant type present in blood at baseline in normal subjects and is elevated in those with systemic mastocytosis
    L B Schwartz
    Department of Medicine, Virginia Commonwealth University, Richmond 23298, USA
    J Clin Invest 96:2702-10. 1995
    Tryptase, a protease produced by all mast cells, was evaluated as a clinical marker of systemic mastocytosis. Two sandwich immunoassays were evaluated, one which used the mAb G5 for capture, the other which used B12 for capture...
  24. ncbi E3 ligase-defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease
    Srinivasa Rao Bandi
    Department of Medicine, Hematology and Oncology and the Interdisciplinary Center for Clinical Research, University Hospital Muenster, Muenster, Germany
    Blood 114:4197-208. 2009
    ..murine bone marrow retrovirally transduced with c-Cbl mutants and transplanted into mice led to a generalized mastocytosis, a myeloproliferative disease, and myeloid leukemia...
  25. doi Gain-of-function mutations in the extracellular domain of KIT are common in canine mast cell tumors
    Sébastien Letard
    Institut National de la Sante et de la Recherche Medicale, U891, Centre de Recherche en Cancerologie de Marseille, Molecular and Functional Hematopoiesis, Marseille F 13009, France
    Mol Cancer Res 6:1137-45. 2008
    ..These results also show that Ba/F3 cells can be used for the direct characterization of canine KIT mutants, eliminating the need to make equivalent mutations in the mouse or human genes...
  26. ncbi Determination of 1-methylhistamine and 1-methylimidazoleacetic acid in human urine as a tool for the diagnosis of mastocytosis
    J Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University Magdeburg, Germany
    J Chromatogr B Biomed Sci Appl 721:135-40. 1999
    ..MHIS) and 1-methylimidazoleacetic acid (MIIA), in human urine is a useful tool for the diagnosis of mastocytosis. MHIS was extracted under basic conditions with chloroform and derivatized with trifluoroacetic acid anhydride, ..
  27. ncbi Class III receptor tyrosine kinases: role in leukaemogenesis
    John T Reilly
    Molecular Haematology Unit, Division of Molecular and Genetic Medicine, Royal Hallamshire Hospital, Sheffield, UK
    Br J Haematol 116:744-57. 2002
  28. ncbi Clinical and histopathological aspects of cutaneous mastocytosis
    K Wolff
    Department of Dermatology, Division of General Dermatology, University of Vienna, Vienna General Hospital, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Leuk Res 25:519-28. 2001
    The organ most frequently involved in mastocytosis is the skin. Cutaneous mastocytosis (CM) is classified according to clinical presentation and is further defined by onset of disease...
  29. ncbi Treatment of cutaneous mastocytosis
    Klaus Wolff
    Department of Dermatology, University of Vienna, Austria
    Int Arch Allergy Immunol 127:156-9. 2002
    Therapy of cutaneous mastocytosis is directed towards skin and systemic symptoms due to mediator release and targeted on skin lesions...
  30. pmc Depression in patients with mastocytosis: prevalence, features and effects of masitinib therapy
    Daniela Silva Moura
    Universite Paris Descartes, Sorbonne, Paris Cité, Service d Hematologie, centre de référence des mastocytoses, Hopital Necker Enfants Malades, Paris, France
    PLoS ONE 6:e26375. 2011
    Depression in patients with mastocytosis is often reported but its prevalence and characteristics are not precisely described...
  31. ncbi Complex karyotype and absence of mutation in the c-kit receptor in aggressive mastocytosis presenting with pelvic osteolysis, eosinophilia and brain damage
    E Jost
    Department of Hematology, Universite Catholique de Louvain, Bruxelles, Belgium
    Ann Hematol 80:302-7. 2001
    Aggressive mastocytosis is a form of systemic mast cell disease (SMCD) characterized by organ infiltration, bone lesions. eosinophilia and lymphadenopathies...
  32. ncbi Effect of granulocyte macrophage colony-stimulating factor in a patient with benign systemic mastocytosis
    T Zuberbier
    Department of Dermatology and Allergy, Charite, Humboldt University, 13344 Berlin, Germany
    Br J Dermatol 145:661-6. 2001
    ..a known inhibitor of in vitro mast cell differentiation, in a patient with benign, adult-onset systemic mastocytosis. In vitro effects of GM-CSF on bone marrow cultures before the start of treatment showed a marked inhibition of ..
  33. ncbi Evidence for altered mast cell proliferation and apoptosis in cutaneous mastocytosis
    K Hartmann
    Departments of Dermatology, University of Cologne, Joseph Stelzmann Str 9, 50931 Cologne, Germany
    Br J Dermatol 149:554-9. 2003
    b>Mastocytosis presents as a focal or generalized increase of mast cells, particularly in the skin, but also in other organs...
  34. doi Mast cells and mastocytosis
    Johan D Soderholm
    Colorectal Surgery Unit, Department of Surgery, University Hospital, Linkoping, Sweden
    Dig Dis 27:129-36. 2009
    ..the tyrosine kinase- receptor for stem cell factor, are associated with the rare disease entity, systemic mastocytosis. These patients present symptoms arising from MC mediator release or infiltration...
  35. ncbi Bullous mastocytosis: a fatal outcome
    M Murphy
    Department of Dermatology, Our Lady's Hospital for Sick Children, Crumlin, Dublin, Ireland
    Pediatr Dermatol 16:452-5. 1999
    A 6-week-old boy was referred with a generalized bullous rash since birth. Examination revealed bullous mastocytosis with initially no evidence of systemic involvement...
  36. pmc Paediatric mastocytosis
    M C Carter
    NIAID NIH, Bethesda, MD 20892 1881, USA
    Arch Dis Child 86:315-9. 2002
  37. ncbi Clinical scoring of cutaneous mastocytosis
    R Heide
    Department of Dermato-Venereology, University Hospital Rotterdam, The Netherlands
    Acta Derm Venereol 81:273-6. 2001
    There are still many controversies in defining and evaluating mastocytosis. One of the aspects that is missing is a system for clinical evaluation of mastocytosis of the skin...
  38. pmc PTEN deficiency in mast cells causes a mastocytosis-like proliferative disease that heightens allergic responses and vascular permeability
    Yasuko Furumoto
    Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    Blood 118:5466-75. 2011
    ..The activating D816V mutation of Kit, seen in the majority of mastocytosis patients, causes a robust activation of PI3K signals...
  39. ncbi Cutaneous mastocytosis -- clinical heterogeneity
    Karin Hartmann
    Department of Dermatology, University Hospital, Cologne, Germany
    Int Arch Allergy Immunol 127:143-6. 2002
    Cutaneous mastocytosis (CM) encompasses several distinct patterns of disease which can be distinguished by the type of skin lesions, age of onset, familial occurrence, noncutaneous involvement, associated c-kit mutations, and prognosis...
  40. ncbi Diffuse cutaneous mastocytosis with bone marrow infiltration in a child: a case report
    L M Waxtein
    Department of Dermatology, , Mexico City, Mexico
    Pediatr Dermatol 17:198-201. 2000
    b>Mastocytosis encompasses a range of disorders characterized by overproliferation and accumulation of tissue mast cells...
  41. ncbi Immunophenotypic analysis of mast cells in mastocytosis: When and how to do it. Proposals of the Spanish Network on Mastocytosis (REMA)
    Luis Escribano
    Unidad de Mastocitosis, Servicio de Hematología and Laboratorio K Frank Austen, Hospital Ramon y Cajal, Madrid, Spain
    Cytometry B Clin Cytom 58:1-8. 2004
    b>Mastocytosis is a term used for a heterogeneous group of disorders characterized by an abnormal proliferation and accumulation of mast cells (MCs) in one or multiple tissues including skin, bone marrow, liver, spleen, and lymph nodes, ..
  42. ncbi Presentation of cutaneous mastocytosis in 173 children
    R Hannaford
    New Children s Hospital, Sydney, New South Wales, Australia
    Australas J Dermatol 42:15-21. 2001
    ..is a retrospective review of the case files and clinical photographs of 173 children diagnosed with cutaneous mastocytosis by a dermatologist in an exclusively paediatric practice...
  43. doi Allergen specific immunotherapy is safe and effective in patients with systemic mastocytosis and Hymenoptera allergy
    Patrizia Bonadonna
    J Allergy Clin Immunol 121:256-7. 2008
  44. doi How much specific is the association between hymenoptera venom allergy and mastocytosis?
    P Bonadonna
    Verona General Hospital, Italy
    Allergy 64:1379-82. 2009
    The preferential association of mastocytosis with hymenoptera sting reactions is well known, but there is no data on the prevalence of clonal mast cell disorders in subjects with severe systemic reactions due to foods or drugs.
  45. ncbi Mastocytosis: mediator-related signs and symptoms
    Mariana Castells
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int Arch Allergy Immunol 127:147-52. 2002
    Patients with systemic mastocytosis present symptoms related to the tissue response to the release of mediators from mast cells and to the local mast cell burden...
  46. ncbi Mastocytosis and allergy
    Matthew Greenhawt
    Division of Allergy and Immunology, Department of Internal Medicine, University of Michigan, School of Medicine, Ann Arbor, Michigan 48109, USA
    Curr Opin Allergy Clin Immunol 7:387-92. 2007
    To illustrate features of allergy in mastocytosis.
  47. ncbi Mastocytosis: recent advances in defining the disease
    K Hartmann
    Department of Dermatology, University of Cologne, Joseph-Stelzmann-Str. 9, 50931 Cologne, Germany
    Br J Dermatol 144:682-95. 2001
    b>Mastocytosis is a rare disease characterized by a primary pathological increase in mast cells in different tissues, which may present in a variety of clinical patterns...
  48. doi Neuropeptide blood levels correlate with mast cell load in patients with mastocytosis
    L Maintz
    Department of Dermatology and Allergy, University of Bonn, Bonn, Germany
    Allergy 66:862-9. 2011
    b>Mastocytosis is characterized by abnormal growth and accumulation of mast cells (MCs) in different organs. MCs have been shown to express receptors for neuropeptides...
  49. pmc Raised tryptase without anaphylaxis or mastocytosis: heterophilic antibody interference in the serum tryptase assay
    R Sargur
    Department of Immunology, Northern General Hospital, Sheffield, UK
    Clin Exp Immunol 163:339-45. 2011
    Mast cell tryptase (MCT) is a key diagnostic test for mastocytosis and anaphylaxis...
  50. ncbi [Systemic mastocytosis--definition of an internal disease]
    Jürgen Homann
    Abteilung fur Innere Medizin, Evangelisches Waldkrankenhaus, Bonn, Germany
    Med Klin (Munich) 105:544-53. 2010
    Systemic mastocytosis comprises disorders characterized by an accumulation of genetically altered mast cells in all organs and tissues due to an increased proliferation rate and reduced apoptosis of those pathologic mast cells...
  51. ncbi Comparative analysis of mutation of tyrosine kinase kit in mast cells from patients with systemic mast cell activation syndrome and healthy subjects
    Gerhard J Molderings
    Institute of Human Genetics, University Hospital of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Immunogenetics 62:721-7. 2010
    ..The present findings support the idea that the systemic mast cell activation syndrome is a clonal disease most commonly associated with variable activating mutations in the tyrosine kinase kit...
  52. doi KIT and mastocytosis
    Ken Hong Lim
    Division of Hematology, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Acta Haematol 119:194-8. 2008
    ..been associated with myeloid malignancies including core binding factor acute myeloid leukemia and systemic mastocytosis (SM), germ cell tumors, gastrointestinal stromal tumors and sinonasal T cell lymphomas...
  53. ncbi Regression of urticaria pigmentosa in adult patients with systemic mastocytosis: correlation with clinical patterns of disease
    Knut Brockow
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 1881, USA
    Arch Dermatol 138:785-90. 2002
    To determine clinical correlates of urticaria pigmentosa (UP) regression in adult patients with systemic mastocytosis (SM).
  54. ncbi Soluble stem cell factor receptor (CD117) and IL-2 receptor alpha chain (CD25) levels in the plasma of patients with mastocytosis: relationships to disease severity and bone marrow pathology
    C Akin
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1881, USA
    Blood 96:1267-73. 2000
    Systemic mastocytosis is a disease of mast cell proliferation that may be associated with hematologic disorders...
  55. ncbi Mastocytosis and Hymenoptera allergy
    Anthony E J Dubois
    Department of Allergology, University Hospital Groningen, Groningen, The Netherlands
    Curr Opin Allergy Clin Immunol 4:291-5. 2004
    b>Mastocytosis is a rare disease with associations with anaphylactic reactions to Hymenoptera stings...
  56. ncbi Pathogenesis, clinical features, and treatment advances in mastocytosis
    A Pardanani
    Division of Hematology, Mayo Clinic, Mayo Building W10A, 200 First Street SW, Rochester, MN 55905, USA
    Best Pract Res Clin Haematol 19:595-615. 2006
    Systemic mastocytosis (SM) is characterized by the abnormal growth and accumulation of mast cells (MC) in one or more organs...
  57. ncbi Prevalence of allergy and anaphylactic symptoms in 210 adult and pediatric patients with mastocytosis in Spain: a study of the Spanish network on mastocytosis (REMA)
    D Gonzalez de Olano
    Allergy Department, Hospital Ramon y Cajal, Madrid, Spain
    Clin Exp Allergy 37:1547-55. 2007
    ..b>Mastocytosis is characterized by an abnormal proliferation and accumulation of mast cells, in which mediators are released ..
  58. ncbi Human mast cells and mastocytosis: harnessing microRNA expression as a new approach to therapy?
    Lorenzo Deho'
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland
    Arch Immunol Ther Exp (Warsz) 58:279-86. 2010
    ....
  59. ncbi Parkinsonism due to bilateral basal ganglia lesions following mastocytosis-induced hypoxia
    Axel Schramm
    J Neurol 251:1270-2. 2004
  60. ncbi Multiple novel alterations in Kit tyrosine kinase in patients with gastrointestinally pronounced systemic mast cell activation disorder
    Gerhard J Molderings
    Institut fur Pharmakologie und Toxikologie, Universitatsklinikum Bonn, Germany
    Scand J Gastroenterol 42:1045-53. 2007
    ....
  61. doi Mastocytosis and insect venom allergy
    Patrizia Bonadonna
    Allergy Unit, Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
    Curr Opin Allergy Clin Immunol 10:347-53. 2010
    To analyse the association of systemic allergic hymenoptera sting reactions with mastocytosis and elevated baseline serum tryptase and to discuss diagnosis and treatment in patients with both diseases.
  62. ncbi Analysis of the surface expression of c-kit and occurrence of the c-kit Asp816Val activating mutation in T cells, B cells, and myelomonocytic cells in patients with mastocytosis
    C Akin
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1881, USA
    Exp Hematol 28:140-7. 2000
    The Asp816Val c-kit activating mutation is detectable in the peripheral blood cells of some patients with mastocytosis and in lesional skin biopsies obtained from adult patients with urticaria pigmentosa...
  63. ncbi Histopathological and immunohistochemical aspects of mastocytosis
    Hans Peter Horny
    Institute of Pathology, Medical University of Lubeck, Germany
    Int Arch Allergy Immunol 127:115-7. 2002
    The diagnosis of mastocytosis is based on histological evidence of a focal increase in tissue mast cells...
  64. ncbi Systemic mastocytosis with plasma cell dyscrasia: report of a case
    Sheeja T Pullarkat
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095, United States
    Leuk Res 32:1160-3. 2008
    Systemic mastocytosis (SM) comprises a heterogeneous group of disorders characterized by infiltration of bone marrow and other tissues by neoplastic mast cells...
  65. ncbi Diagnostic criteria and classification of mastocytosis: a consensus proposal
    P Valent
    Department of Internal Medicine I, Division of Hematology, University of Vienna, Währinger Gürtel 18 20 Vienna, Austria
    Leuk Res 25:603-25. 2001
    The term 'mastocytosis' denotes a heterogeneous group of disorders characterized by abnormal growth and accumulation of mast cells (MC) in one or more organ systems...
  66. ncbi Recent advances in the understanding of mastocytosis: the role of KIT mutations
    Alberto Orfao
    Centro de Investigación del Cáncer IBMCC, Departamento de Medicina and Servicio General de Citometría, University of Salamanca, Salamanca, Spain
    Br J Haematol 138:12-30. 2007
    b>Mastocytosis is a heterogeneous disorder characterised by the expansion and accumulation of mast cells in different organs and tissues...
  67. pmc Mastocytosis in mice expressing human Kit receptor with the activating Asp816Val mutation
    Jacques P Zappulla
    Institut National de la Sante et de la Recherche Medicale U563, Centre de Physiopathologie de Toulouse Purpan, Purpan Hospital, 31000 Toulouse, France
    J Exp Med 202:1635-41. 2005
    b>Mastocytosis is a rare neoplastic disease characterized by a pathologic accumulation of tissue mast cells (MCs)...
  68. ncbi Serum interleukin-6 reflects disease severity and osteoporosis in mastocytosis patients
    Theoharis C Theoharides
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, New England Medical Center, Boston, Mass 02111, USA
    Int Arch Allergy Immunol 128:344-50. 2002
    Systemic mastocytosis (SM) is a condition typically characterized by an increased number of mast cells in the bone marrow or in skin areas known as urticaria pigmentosa...
  69. ncbi Acute stress-induced seizures and loss of consciousness in a ten-year-old boy with cutaneous mastocytosis
    Christos Pehlivanidis
    J Clin Psychopharmacol 22:221-4. 2002
  70. doi Anaphylaxis in patients with mastocytosis: a study on history, clinical features and risk factors in 120 patients
    K Brockow
    Department of Dermatology and Allergy Biederstein, Technical University Munich, Munich, Germany
    Allergy 63:226-32. 2008
    Excessive mast cell mediator release may lead to anaphylaxis in patients with mastocytosis. However, the incidence, clinical features and trigger factors have not yet been analyzed.
  71. doi Pediatric mastocytosis-associated KIT extracellular domain mutations exhibit different functional and signaling properties compared with KIT-phosphotransferase domain mutations
    Ying Yang
    INSERM U891, Centre de Recherche en Cancerologie de Marseille, Laboratoire de Signalisation, Hématopoïèse et Mécanisme de l Oncogenèse, Centre de Référence des Mastocytoses CEREMAST Institut Paoli Calmettes, 27 Boulevard Lei Roure, Marseille, France
    Blood 116:1114-23. 2010
    Compared with adults, pediatric mastocytosis has a relatively favorable prognosis. Interestingly, a difference was also observed in the status of c-kit mutations according to the age of onset...
  72. pmc Cutaneous mucinosis and mastocytosis in a shar-pei
    A Lopez
    Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island
    Can Vet J 40:881-3. 1999
    ..The condition reappeared 2 years later and subsequent biopsies revealed a mast cell tumor in some of the skin sites previously diagnosed with mucinosis...
  73. ncbi IL-6 levels predict disease variant and extent of organ involvement in patients with mastocytosis
    Knut Brockow
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892 1881, USA
    Clin Immunol 115:216-23. 2005
    b>Mastocytosis is often associated with organ involvement and hematological disorders. Patients may also exhibit elevated levels of plasma IL-6...
  74. doi Mast cells from different molecular and prognostic subtypes of systemic mastocytosis display distinct immunophenotypes
    Cristina Teodosio
    Servicio General de Citometria, Instituto de Biologia Molecular y Celular del Cancer, Centro de Investigación del Cáncer IBMCC CSIC USAL and Departamento de Medicina, Universidad de Salamanca, Salamanca, Spain
    J Allergy Clin Immunol 125:719-26, 726.e1-726.e4. 2010
    Systemic mastocytosis (SM) is a heterogeneous group of disorders with distinct clinical and biological behavior. Despite this, little is known about the immunophenotypic features of the distinct diagnostic categories of SM.
  75. pmc Case-control cohort study of patients' perceptions of disability in mastocytosis
    Olivier Hermine
    Service de Dermatologie, Centre de référence sur la mastocytose, Hopital Necker, Paris, France
    PLoS ONE 3:e2266. 2008
    Indolent forms of mastocytosis account for more than 90% of all cases, but the types and type and severity of symptoms and their impact on the quality of life have not been well studied...
  76. doi High omalizumab dose controls recurrent reactions to venom immunotherapy in indolent systemic mastocytosis
    K Kontou-Fili
    Chief Allergology Department, Euroclinic Hospital, Athens, 8 Fidippidou st, Athens 11526, Hellas, Greece
    Allergy 63:376-8. 2008
  77. ncbi Mastocytosis and fibrosis: role of cytokines
    Chin Yang Li
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Int Arch Allergy Immunol 127:123-6. 2002
    b>Mastocytosis is a rare stem cell disorder characterized by abnormal growth and accumulation of mast cells in one or more organ systems. Clinical heterogeneity is a hallmark of mastocytosis...
  78. ncbi Serum tryptase and the laboratory diagnosis of systemic mastocytosis
    L B Schwartz
    Division of Rheumatology, Allergy, and Immunology, Virginia Commonwealth University, Richmond, USA
    Hematol Oncol Clin North Am 14:641-57. 2000
    ..serum sample when the ratio of total to beta-tryptase is 20 or greater strongly suggest underlying systemic mastocytosis. Whether these criteria prove to be more sensitive than a bone marrow biopsy will require further study...
  79. ncbi Diagnosis of mastocytosis: general histopathological aspects, morphological criteria, and immunohistochemical findings
    H P Horny
    Institute of Pathology, Medical University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Leuk Res 25:543-51. 2001
    ..in mast cell (MC) numbers in hemopoietic tissues may be associated with (a) primary neoplastic MC disease (mastocytosis); (b) non-mast cell lineage myelogenous disorders (myelodysplastic or myeloproliferative syndromes and myeloid ..
  80. ncbi Spectrum of associated clonal hematologic non-mast cell lineage disorders occurring in patients with systemic mastocytosis
    Wolfgang R Sperr
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, Austria
    Int Arch Allergy Immunol 127:140-2. 2002
    Systemic mastocytosis (SM) is a myeloproliferative disease affecting multipotent and/or mast cell-committed hematopoietic progenitor cells...
  81. ncbi Myelomastocytic overlap syndromes: biology, criteria, and relationship to mastocytosis
    P Valent
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Leuk Res 25:595-602. 2001
    ..three major groups of patients have been recognized: The first meets criteria for both diagnoses 'systemic mastocytosis' and 'associated hematologic clonal non-mast cell lineage disease (AHNMD)'...
  82. ncbi Diagnostic evaluation and classification of mastocytosis
    Peter Valent
    Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Wahringer Gurtel 18 20, Vienna, Austria
    Immunol Allergy Clin North Am 26:515-34. 2006
    During the past few years, mastocytosis research has reached important milestones, including the formulation of diagnostic criteria, definition of markers, and targeting of mutated KIT...
  83. ncbi Mast cell mediators in allergic inflammation and mastocytosis
    Mariana Castells
    Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA
    Immunol Allergy Clin North Am 26:465-85. 2006
    ..prostaglandins, leukotrienes, cytokines, and chemokines leads to chronic and debilitating disease, such as mastocytosis. Identification of the molecular factors and mechanisms that control the synthesis and release of mast cell ..
  84. ncbi RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demon
    Yi Yang
    Department of Medicine, Brigham and Women s Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:25756-74. 2002
    ..Transcript analysis of an asthma patient, a mastocytosis patient, and the HMC-1 cell line derived from a MC leukemia patient revealed the presence of substantial ..
  85. ncbi Mutation analysis of C-KIT in patients with myelodysplastic syndromes without mastocytosis and cases of systemic mastocytosis
    R Fritsche-Polanz
    Department of Laboratory Medicine, Division of Endocrinology and Metabolism, University of Vienna, Vienna, Austria
    Br J Haematol 113:357-64. 2001
    ..that is expressed on mast cells and haematopoietic stem cells and can show somatic mutations in patients with mastocytosis. Only scattered information is available about mutations in C-KIT in patients with other myeloid neoplasms...
  86. pmc Intestinal protection against Strongyloides ratti and mastocytosis induced by administration of interleukin-3 in mice
    T Abe
    Department of Parasitology, Akita University School of Medicine, Japan
    Immunology 80:116-21. 1993
    ..The IL-3 treatment induced no protection or mastocytosis in mast cell-deficient W/Wv mice. These results suggest that the IL-3-induced intestinal protection against S...
  87. ncbi Current options in the treatment of mast cell mediator-related symptoms in mastocytosis
    Luis Escribano
    Unidad de Mastocitosis, Laboratorio K Frank Austen, Hospital Ramon y Cajal, Red Española de Mastocitosis, Madrid, Spain
    Inflamm Allergy Drug Targets 5:61-77. 2006
    Patients with mastocytosis have symptoms related to the tissue response to the release of mediators from mast cells (MC), local mast cell burden or associated non-mast cell hematological disorders...
  88. pmc Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder
    H Nagata
    Allergic Diseases Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 92:10560-4. 1995
    ..These observations suggested to us that mastocytosis might in some patients result from mutations in c-kit...
  89. pmc Tryptase haplotype in mastocytosis: relationship to disease variant and diagnostic utility of total tryptase levels
    Cem Akin
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA
    Clin Immunol 123:268-71. 2007
    Serum mast cell tryptase levels are used as a diagnostic criterion and surrogate marker of disease severity in mastocytosis. Approximately 29% of the healthy population lacks alpha tryptase genes; however, it is not known whether lack of ..
  90. ncbi Mastocytosis: classification, diagnosis, and clinical presentation
    Mariana C Castells
    Brigham and Women s Hospital, Harvard Medical School, 1 Jimmy Fund Way, Smith Building, Room 626D Boston, MA 02115, USA
    Allergy Asthma Proc 25:33-6. 2004
    b>Mastocytosis comprises several diseases characterized by an abnormal increase in tissue mast cells...
  91. ncbi Morphologic properties of neoplastic mast cells: delineation of stages of maturation and implication for cytological grading of mastocytosis
    W R Sperr
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, University of Vienna, , 1090 Vienna, Austria
    Leuk Res 25:529-36. 2001
    ..bone marrow mast cells (MC) were analyzed and correlated with clinical parameters in 69 patients with systemic mastocytosis (SM)...
  92. ncbi IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development
    J M Townsend
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Immunity 13:573-83. 2000
    ..a distinct requirement for IL-9 in the rapid and robust generation of pulmonary goblet cell hyperplasia and mastocytosis in response to lung challenge. In contrast, eosinophilia and granuloma formation were not affected...
  93. pmc Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis
    B J Longley
    Departments of Dermatology and Pathology, Section of Dermatopathology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 96:1609-14. 1999
    Human mastocytosis is characterized by increased mast cells. It usually occurs as a sporadic disease that is often transient and limited in children and persistent or progressive in adults...
  94. doi Mastocytosis in children: a protocol for management
    Rogier Heide
    Department of Dermatology, Medisch Centrum Alkmaar, Alkmaar, The Netherlands
    Pediatr Dermatol 25:493-500. 2008
    b>Mastocytosis is characterized by an increased number of mast cells with an abnormal growth and accumulation in one or more organs...
  95. ncbi Clinical correlates of the presence of the Asp816Val c-kit mutation in the peripheral blood mononuclear cells of patients with mastocytosis
    A S Worobec
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1881, USA
    Cancer 83:2120-9. 1998
    The Asp816Val mutation in the catalytic domain of the c-kit receptor has been identified in patients with systemic mastocytosis.
  96. ncbi Mastocytosis: state of the art
    Hans Peter Horny
    Institute of Pathology, Ansbach, Germany
    Pathobiology 74:121-32. 2007
    b>Mastocytosis is a neoplastic disease involving mast cells (MC) and their CD34+ progenitors...
  97. ncbi IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13
    Padraic G Fallon
    Immunomodulation Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Immunity 17:7-17. 2002
    ..These mice reveal distinct spatial, temporal, and hierarchical cytokine requirements in immune function...
  98. ncbi Novel germline mutation of KIT associated with familial gastrointestinal stromal tumors and mastocytosis
    Karin Hartmann
    Department of Dermatology, University of Cologne, Cologne, Germany
    Gastroenterology 129:1042-6. 2005
    ..Sporadic mastocytosis in adults is usually also caused by KIT mutations that, however, activate KIT by affecting the intracellular ..
  99. pmc Acute myeloid leukaemia with t(8;21) associated with "occult" mastocytosis. Report of an unusual case and review of the literature
    H W Bernd
    Institute of Pathology, Medical University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    J Clin Pathol 57:324-8. 2004
    Approximately 20% of patients with systemic mastocytosis (SM) have an associated haematological, clonal, non-mast cell lineage disease, and most exhibit an associated myelogenous neoplasm...
  100. ncbi Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit gene
    A Selim Yavuz
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIAMS, and Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 100:661-5. 2002
    Mast cells are derived from multipotential hematopoietic progenitors and are clonally increased in systemic mastocytosis, a disease associated with point mutations of codon 816 (most commonly Asp816Val) of c-kit...
  101. ncbi IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis
    J F Urban
    United States Department of Agriculture, Beltsville, Maryland 20705, USA
    Immunity 8:255-64. 1998
    ..Additional observations made in the course of these experiments demonstrate that Stat6 signaling is not required for IL-4 enhancement of IgG1 production and actually inhibits IL-4-induction of mucosal mastocytosis.

Research Grants72

  1. Oncogenic Kit receptor signaling in vivo
    Peter Besmer; Fiscal Year: 2009
    ..In human neoplasia oncogenic activation of Kit has roles in gastrointestinal stromal tumors (GIST), mastocytosis/mast cell leukemia, acute myelogenous leukemia, a subset of melanomas and a subset of germ cell tumors...
  2. Oncogenic Kit receptor signaling in vivo
    Peter Besmer; Fiscal Year: 2010
    ..In human neoplasia oncogenic activation of Kit has roles in gastrointestinal stromal tumors (GIST), mastocytosis/mast cell leukemia, acute myelogenous leukemia, a subset of melanomas and a subset of germ cell tumors...
  3. A Mouse Model for Human Gastrointestinal Stromal Tumor
    Peter Besmer; Fiscal Year: 2010
    ..In human neoplasia oncogenic activation of Kit has roles in gastrointestinal stromal tumors, mastocytosis/mast cell leukemia, acute myelogenous leukemia, a minor subset of melanomas and a subset of germ cell tumors...
  4. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2003
    ..Symptoms of urinary frequency and pelvic pain commonly worsen perimenstrually and under stress in IC. Bladder mastocytosis with mast cell activation has been documented in IC...
  5. System for Rapid Generation of Aptamers for Transplant Therapies
    KAREN QIAN; Fiscal Year: 2010
    ..and solid tumors such as acute myeloid leukemia, myelodysplastic syndromes, chronic myeloid leukemia, systemic mastocytosis and breast cancer...
  6. GROWTH AND DIFFERENTIATION OF HUMAN MAST CELLS
    ROBERT BRESSLER; Fiscal Year: 1990
    ..more similar to basophils than mast cells, whereas HCGC derived from bone marrow of a patient with systemic mastocytosis (SM), were more characteristic of mast cells...
  7. Role of Vav and Rac in KIT oncogenesis
    Reuben Kapur; Fiscal Year: 2010
    ..gastrointestinal stromal tumors (GISTs), sinonasal lymphomas, acute myeloid leukemia (AML), and systemic mastocytosis (SM). A significant proportion of these diseases commonly bear the KIT activation loop mutation KITD816V...
  8. Role of Vav and Rac in KIT oncogenesis
    Reuben Kapur; Fiscal Year: 2009
    ..gastrointestinal stromal tumors (GISTs), sinonasal lymphomas, acute myeloid leukemia (AML), and systemic mastocytosis (SM). A significant proportion of these diseases commonly bear the KIT activation loop mutation KITD816V...
  9. Role of Vav and Rac in KIT oncogenesis
    Reuben Kapur; Fiscal Year: 2011
    ..gastrointestinal stromal tumors (GISTs), sinonasal lymphomas, acute myeloid leukemia (AML), and systemic mastocytosis (SM). A significant proportion of these diseases commonly bear the KIT activation loop mutation KITD816V...
  10. HUMAN STRONGYLOIDIASIS: DEVELOPMENT OF A CANINE MODEL
    Gerhard Schad; Fiscal Year: 1991
    ..3) To determine whether, as recently suggested for simian strongyloidiasis, local mastocytosis and release of mast cell mediators correlate with critical developmental events in the intestinal life of the ..
  11. HUMAN STRONGYLOIDIASIS--DEVELOPMENT OF A CANINE MODEL
    Gerhard Schad; Fiscal Year: 1992
    ..3) To determine whether, as recently suggested for simian strongyloidiasis, local mastocytosis and release of mast cell mediators correlate with critical developmental events in the intestinal life of the ..
  12. HUMAN STRONGYLOIDIASIS: DEVELOPMENT OF A CANINE MODEL
    Gerhard Schad; Fiscal Year: 1990
    ..3) To determine whether, as recently suggested for simian strongyloidiasis, local mastocytosis and release of mast cell mediators correlate with critical developmental events in the intestinal life of the ..
  13. IMMUNOLOGIC RELEASE OF CHEMICAL MEDIATORS IN MAN
    FRANK AUSTEN; Fiscal Year: 1990
    ..Mast cells will be defined in situ in patients with systemic mastocytosis and chemically/immunochemically in biopsy tissues to seek differences which might be highlighted by a ..
  14. DIFFERENT IMBALANCES OF CYTOKINES IN NEMATODE INFECTIONS
    Norman Reed; Fiscal Year: 1990
    ..Nippostrongylus brasiliensis (Nb) and Trichinella spiralis (Ts) cause striking intestinal mastocytosis; by contrast, Nematospiroides dubius (Nd) not only fails to cause mastocytosis but also inhibits the ..
  15. SECRETION OF BLADDER MAST CELL MEDIATORS IN IC
    Theoharis Theoharides; Fiscal Year: 1990
    ..IgE) and antigen (Ag) leading to increased secretion of inflammatory mediators in allergies, asthma, systemic mastocytosis and pruritus...
  16. CELLULAR BASIS OF HYPERSENSITIVITY DISEASES IN HUMANS
    FRANK AUSTEN; Fiscal Year: 1991
    ..exercise-associated anaphylaxis, cold-induced urticaria, dermographism, and cholinergic urticaria), systemic mastocytosis, and bullous pemphigoid...
  17. Activating PTPN11 and c-kit Mutations in Myeloproliferative Disorder
    Rebecca Chan; Fiscal Year: 2007
    ..receptor protein tyrosine kinase for stem cell factor (SCF), in juvenile myelomonocytic leukemia and systemic mastocytosis, respectively...
  18. Activating PTPN11 and c-kit Mutations in Myeloprolifera*
    Rebecca Chan; Fiscal Year: 2006
    ..receptor protein tyrosine kinase for stem cell factor (SCF), in juvenile myelomonocytic leukemia and systemic mastocytosis, respectively...
  19. Activating PTPN11 and c-kit Mutations in Myeloprolifera*
    Rebecca Chan; Fiscal Year: 2005
    ..receptor protein tyrosine kinase for stem cell factor (SCF), in juvenile myelomonocytic leukemia and systemic mastocytosis, respectively...
  20. Metabolic Disposition Of Cyclopentenone Eicosanoids
    L Roberts; Fiscal Year: 2001
    ..these metabolites can be detected in normal human urine and whether levels increase in patients with systemic mastocytosis which is associated with a marked overproduction of PGD2 and in normal volunteers following administration of ..
  21. Mechanisms of Tyrosine Kinase Inhibitor Resistance in GI Stromal Tumors
    Michael Heinrich; Fiscal Year: 2009
    ..g. melanoma, acute myeloid leukemia, seminoma, and mastocytosis)...
  22. CUTANEOUS BIOLOGY OF KIT LIGAND
    JACK LONGLEY; Fiscal Year: 1999
    The goal of this proposal is to determine the role in the pathogenesis of the disease mastocytosis played by the c-KIT proto-oncogene, the KIT receptor tyrosine kinase that it encodes, and the ligand for KIT...
  23. CUTANEOUS BIOLOGY OF KIT LIGAND
    JACK LONGLEY; Fiscal Year: 2000
    The goal of this proposal is to determine the role in the pathogenesis of the disease mastocytosis played by the c-KIT proto-oncogene, the KIT receptor tyrosine kinase that it encodes, and the ligand for KIT...
  24. Recruitment of Murine Mast Cell Progenitors
    JUAN ABONIA; Fiscal Year: 2004
    ..Additionally a significant intestinal mastocytosis is also noted in the challenged animals...
  25. Recruitment of Murine Mast Cell Progenitors
    JUAN ABONIA; Fiscal Year: 2007
    ..Additionally a significant intestinal mastocytosis is also noted in the challenged animals...
  26. Recruitment of Murine Mast Cell Progenitors
    JUAN ABONIA; Fiscal Year: 2006
    ..Additionally a significant intestinal mastocytosis is also noted in the challenged animals...
  27. Recruitment of Murine Mast Cell Progenitors
    JUAN ABONIA; Fiscal Year: 2004
    ..Additionally a significant intestinal mastocytosis is also noted in the challenged animals...
  28. Recruitment of Murine Mast Cell Progenitors
    JUAN ABONIA; Fiscal Year: 2005
    ..Additionally a significant intestinal mastocytosis is also noted in the challenged animals...
  29. Novel Mechanisms of C-Kit Regulation in Mast Cells
    Reuben Kapur; Fiscal Year: 2009
    ..facilitate the design of specific molecular therapies for the treatment of mast cell disorders, including human mastocytosis associated with gain-of-function mutations of c-Kit, chronic inflammation, allergy as well as for promoting ..
  30. Novel Mechanisms of C-Kit Regulation in Mast Cells
    Reuben Kapur; Fiscal Year: 2006
    ..facilitate the design of specific molecular therapies for the treatment of mast cell disorders, including human mastocytosis associated with gain-of-function mutations of c-Kit, chronic inflammation, allergy as well as for promoting ..
  31. Novel Mechanisms of C-Kit Regulation in Mast Cells
    Reuben Kapur; Fiscal Year: 2007
    ..facilitate the design of specific molecular therapies for the treatment of mast cell disorders, including human mastocytosis associated with gain-of-function mutations of c-Kit, chronic inflammation, allergy as well as for promoting ..
  32. PROSTANOID BIOSYNTHESIS IN SYSTEMIC MASTOCYTOSIS
    John Oates; Fiscal Year: 2003
    ..research is to examine the biosynthesis of the mast cell mediator, prostaglandin D2, in patients with systemic mastocytosis, and to explore the potential for improvements in the treatment of this disorder...
  33. PROSTANOID BIOSYNTHESIS IN SYSTEMIC MASTOCYTOSIS
    John Oates; Fiscal Year: 2002
    ..research is to examine the biosynthesis of the mast cell mediator, prostaglandin D2, in patients with systemic mastocytosis, and to explore the potential for improvements in the treatment of this disorder...
  34. PROSTANOID BIOSYNTHESIS IN SYSTEMIC MASTOCYTOSIS
    John Oates; Fiscal Year: 2001
    ..research is to examine the biosynthesis of the mast cell mediator, prostaglandin D2, in patients with systemic mastocytosis, and to explore the potential for improvements in the treatment of this disorder...
  35. MICROPHTHALMIA--CRITICAL FACTOR IN MAST CELL DEVELOPMENT
    Clifford Takemoto; Fiscal Year: 1999
    ..In addition, mast cell hyperplasia results in disorders such as mastocytosis. Thus, mast cells are not only an important disease-specific cell lineage, but also provide an attractive ..
  36. MICROPHTHALMIA--CRITICAL FACTOR IN MAST CELL DEVELOPMENT
    Clifford Takemoto; Fiscal Year: 2001
    ..In addition, mast cell hyperplasia results in disorders such as mastocytosis. Thus, mast cells are not only an important disease-specific cell lineage, but also provide an attractive ..
  37. CysLT and P2Y Receptors in Lung Inflammation
    Joshua A Boyce; Fiscal Year: 2010
    ..preliminary studies now demonstrate that cys-LTs play an unanticipated, essential role in mediating reactive mastocytosis in a model of allergen-induced pulmonary inflammation...
  38. CysLT and P2Y Receptors in Lung Inflammation
    Joshua Boyce; Fiscal Year: 2009
    ..preliminary studies now demonstrate that cys-LTs play an unanticipated, essential role in mediating reactive mastocytosis in a model of allergen-induced pulmonary inflammation...
  39. CysLt and P2Y Receptors and Lung Inflammation
    Joshua Boyce; Fiscal Year: 2007
    ..of an autocrine/intracrine signaling loop that is essential for the expansion of MC numbers (reactive mastocytosis) occurring in the lung and intestinal mucosal surfaces in Th2-biased immune responses in vivo...
  40. CysLT and P2Y Receptors in Lung Inflammation
    Joshua Boyce; Fiscal Year: 2009
    ..preliminary studies now demonstrate that cys-LTs play an unanticipated, essential role in mediating reactive mastocytosis in a model of allergen-induced pulmonary inflammation...
  41. CysLT and P2Y Receptors in Lung Inflammation
    Joshua Boyce; Fiscal Year: 2009
    ..preliminary studies now demonstrate that cys-LTs play an unanticipated, essential role in mediating reactive mastocytosis in a model of allergen-induced pulmonary inflammation...
  42. BIOCHEMISTRY OF MAST CELL SECRETORY GRANULE ENZYMES
    Lawrence Schwartz; Fiscal Year: 2000
    ..used to assess mast cell involvement in human diseases such as asthma, systemic anaphylaxis and systemic mastocytosis, the biochemical characterization of the enzyme as a heparin-stabilized tetramer resistant to biologic protease ..
  43. Mechanism of Normal and Ocogenic Kit Signaling in Vivo
    Peter Besmer; Fiscal Year: 2003
    ..In human neoplasia oncogenic activation of Kit is thought to have roles in mastocytosis/mast cell leukemia, acute myelogenous leukemia, gastro intestinal stromal tumors (GlST) and germ cell tumors...
  44. Mechanism of Normal and Ocogenic Kit Signaling in Vivo
    Peter Besmer; Fiscal Year: 2005
    ..In human neoplasia oncogenic activation of Kit is thought to have roles in mastocytosis/mast cell leukemia, acute myelogenous leukemia, gastro intestinal stromal tumors (GlST) and germ cell tumors...
  45. Mechanism of Normal and Ocogenic Kit Signaling in Vivo
    Peter Besmer; Fiscal Year: 2006
    ..In human neoplasia oncogenic activation of Kit is thought to have roles in mastocytosis/mast cell leukemia, acute myelogenous leukemia, gastro intestinal stromal tumors (GlST) and germ cell tumors...
  46. Mechanism of Normal and Ocogenic Kit Signaling in Vivo
    Peter Besmer; Fiscal Year: 2002
    ..In human neoplasia oncogenic activation of Kit is thought to have roles in mastocytosis/mast cell leukemia, acute myelogenous leukemia, gastro intestinal stromal tumors (GlST) and germ cell tumors...
  47. Mechanism of Normal and Ocogenic Kit Signaling in Vivo
    Peter Besmer; Fiscal Year: 2004
    ..In human neoplasia oncogenic activation of Kit is thought to have roles in mastocytosis/mast cell leukemia, acute myelogenous leukemia, gastro intestinal stromal tumors (GlST) and germ cell tumors...
  48. IMMUNITY TO PARASITIC INFECTION
    Judith Appleton; Fiscal Year: 2007
    ..We will recreate the immune intestine by eliciting mastocytosis in rats independently of intestinal T...
  49. IMMUNITY TO PARASITIC INFECTION
    Judith Appleton; Fiscal Year: 2005
    ..We will recreate the immune intestine by eliciting mastocytosis in rats independently of intestinal T...
  50. IMMUNITY TO PARASITIC INFECTION
    Judith Appleton; Fiscal Year: 2004
    ..We will recreate the immune intestine by eliciting mastocytosis in rats independently of intestinal T...
  51. IMMUNITY TO PARASITIC INFECTION
    Judith Appleton; Fiscal Year: 2006
    ..We will recreate the immune intestine by eliciting mastocytosis in rats independently of intestinal T...
  52. CUTANEOUS BIOLOGY OF KIT LIGAND
    JACK LONGLEY; Fiscal Year: 2004
    ..The goal of this proposal is to determine the role of the SCF-KIT signaling pathway in mastocytosis and cutaneous inflammation...
  53. CUTANEOUS BIOLOGY OF KIT LIGAND
    JACK LONGLEY; Fiscal Year: 2001
    ..The goal of this proposal is to determine the role of the SCF-KIT signaling pathway in mastocytosis and cutaneous inflammation...
  54. CUTANEOUS BIOLOGY OF KIT LIGAND
    JACK LONGLEY; Fiscal Year: 2005
    ..The goal of this proposal is to determine the role of the SCF-KIT signaling pathway in mastocytosis and cutaneous inflammation...
  55. CUTANEOUS BIOLOGY OF KIT LIGAND
    JACK LONGLEY; Fiscal Year: 2002
    ..The goal of this proposal is to determine the role of the SCF-KIT signaling pathway in mastocytosis and cutaneous inflammation...
  56. CUTANEOUS BIOLOGY OF KIT LIGAND
    JACK LONGLEY; Fiscal Year: 2003
    ..The goal of this proposal is to determine the role of the SCF-KIT signaling pathway in mastocytosis and cutaneous inflammation...
  57. CUTANEOUS BIOLOGY OF KIT LIGAND
    JACK LONGLEY; Fiscal Year: 2001
    ..The goal of this proposal is to determine the role of the SCF-KIT signaling pathway in mastocytosis and cutaneous inflammation...
  58. MICROPHTHALMIA--CRITICAL FACTOR IN MAST CELL DEVELOPMENT
    Clifford Takemoto; Fiscal Year: 2000
    ..In addition, mast cell hyperplasia results in disorders such as mastocytosis. Thus, mast cells are not only an important disease-specific cell lineage, but also provide an attractive ..
  59. CYCLOOXYGENASE 2 /PROSTAGLANDIN D2 IN MASTOCYTOSIS
    John Oates; Fiscal Year: 2000
    ..that the isoenzyme, cyclooxygenase-2, is the major source of prostaglandin S2 production in patients w/systemic mastocytosis. SPECIFIC AIM: 1) The principal specific aim of this study is to determine whether a selective inhibitor of; ..
  60. Gene and Protein Defects Causing Mastocytosis
    Yongsheng Ma; Fiscal Year: 2003
    The goal of this proposal is to add to the understanding of the mechanisms underlying the pathogenesis of mastocytosis. They have previously shown that essentially all adult and atypical pediatric mastocytosis are characterized by ..
  61. Gene and Protein Defects Causing Mastocytosis
    Yongsheng Ma; Fiscal Year: 2004
    The goal of this proposal is to add to the understanding of the mechanisms underlying the pathogenesis of mastocytosis. They have previously shown that essentially all adult and atypical pediatric mastocytosis are characterized by ..
  62. Gene and Protein Defects Causing Mastocytosis
    Yongsheng Ma; Fiscal Year: 2005
    The goal of this proposal is to add to the understanding of the mechanisms underlying the pathogenesis of mastocytosis. They have previously shown that essentially all adult and atypical pediatric mastocytosis are characterized by ..
  63. Gene and Protein Defects Causing Mastocytosis
    Yongsheng Ma; Fiscal Year: 2007
    The goal of this proposal is to add to the understanding of the mechanisms underlying the pathogenesis of mastocytosis. They have previously shown that essentially all adult and atypical pediatric mastocytosis are characterized by ..
  64. Gene and Protein Defects Causing Mastocytosis
    Yongsheng Ma; Fiscal Year: 2006
    The goal of this proposal is to add to the understanding of the mechanisms underlying the pathogenesis of mastocytosis. They have previously shown that essentially all adult and atypical pediatric mastocytosis are characterized by ..