hypertrichosis

Summary

Summary: Excessive hair growth at inappropriate locations, such as on the extremities, the head, and the back. It is caused by genetic or acquired factors, and is an androgen-independent process. This concept does not include HIRSUTISM which is an androgen-dependent excess hair growth in WOMEN and CHILDREN.

Top Publications

  1. ncbi Primary generalized and localized hypertrichosis in children
    R A Vashi
    Division of Dermatology, Children's Memorial Hospital, 2300 Children's Plaza-107, Chicago, IL 60614, USA
    Arch Dermatol 137:877-84. 2001
  2. ncbi [Side-effects and risk profile of latanoprost 0.005% (Xalatan)]
    T Schlote
    Universitäts Augenklinik Tübingen, Abteilung I
    Ophthalmologe 99:724-9. 2002
  3. ncbi Comparative study on a single treatment response to long pulse Nd:YAG lasers and intense pulse light therapy for hair removal on skin type IV to VI--is longer wavelengths lasers preferred over shorter wavelengths lights for assisted hair removal
    C L Goh
    Dermatological and Laser Surgery Unit, National Skin Centre, 1 Mandalay Road, Singapore 305205
    J Dermatolog Treat 14:243-7. 2003
  4. ncbi Linear congenital Becker nevus
    Young Suck Ro
    Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea
    Cutis 75:122-4. 2005
  5. ncbi CO2 laser desiccation of urethral hair post-penoscrotal hypospadias repair
    Sarit Cohen
    Department of Plastic Surgery, Tel Aviv University, Tel Aviv, Israel
    J Cosmet Laser Ther 9:241-3. 2007
  6. pmc Trps1 and its target gene Sox9 regulate epithelial proliferation in the developing hair follicle and are associated with hypertrichosis
    Katherine A Fantauzzo
    Department of Dermatology, Columbia University, New York, NY, USA
    PLoS Genet 8:e1003002. 2012
  7. pmc X-linked congenital hypertrichosis syndrome is associated with interchromosomal insertions mediated by a human-specific palindrome near SOX3
    Hongwen Zhu
    McKusick Zhang Center for Genetic Medicine and State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China
    Am J Hum Genet 88:819-26. 2011
  8. ncbi Characterization of an in vivo model for the study of eyelash biology and trichomegaly: mouse eyelash morphology, development, growth cycle, and anagen prolongation by bimatoprost
    M Tauchi
    Institute of Anatomy II, University of Erlangen Nuremberg, Erlangen, Germany
    Br J Dermatol 162:1186-97. 2010
  9. ncbi SLC29A3 gene is mutated in pigmented hypertrichosis with insulin-dependent diabetes mellitus syndrome and interacts with the insulin signaling pathway
    Simon T Cliffe
    Department of Haematology and Genetics, South Eastern Area Laboratory Services, Sydney, NSW 2031, Australia
    Hum Mol Genet 18:2257-65. 2009
  10. ncbi Hypertrichosis lanuginosa congenita
    Vibhu Mendiratta
    Lady Hardinge Medical College, Associated Shrimati Sucheta Kriplani and Kalawati Saran Childrens Hospital, New Delhi, India
    Pediatr Dermatol 25:483-4. 2008

Detail Information

Publications215 found, 100 shown here

  1. ncbi Primary generalized and localized hypertrichosis in children
    R A Vashi
    Division of Dermatology, Children's Memorial Hospital, 2300 Children's Plaza-107, Chicago, IL 60614, USA
    Arch Dermatol 137:877-84. 2001
    OBJECTIVE: To review the causes, presentation, and therapy of primary generalized and localized symmetrical hypertrichosis in children. DESIGN: Retrospective medical record review...
  2. ncbi [Side-effects and risk profile of latanoprost 0.005% (Xalatan)]
    T Schlote
    Universitäts Augenklinik Tübingen, Abteilung I
    Ophthalmologe 99:724-9. 2002
    ..Latanoprost, a prostaglandin F(2alpha)-analogue, has been widely in use in clinical practice for a period of over 5 years. The side-effects of latanoprost are analyzed and the clinical relevance is discussed...
  3. ncbi Comparative study on a single treatment response to long pulse Nd:YAG lasers and intense pulse light therapy for hair removal on skin type IV to VI--is longer wavelengths lasers preferred over shorter wavelengths lights for assisted hair removal
    C L Goh
    Dermatological and Laser Surgery Unit, National Skin Centre, 1 Mandalay Road, Singapore 305205
    J Dermatolog Treat 14:243-7. 2003
    ..To investigate the safety and effectiveness of a long pulsed Nd:YAG (1064nm) laser compared to a shorter wavelength intense pulse light system for assisted hair removal in volunteers with skin type 1V, V and VI...
  4. ncbi Linear congenital Becker nevus
    Young Suck Ro
    Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea
    Cutis 75:122-4. 2005
    ..We describe a case of linear congenial Becker nevus following Blaschko line that appeared at birth on the right shoulder, with hypertrichosis developing 4 years later.
  5. ncbi CO2 laser desiccation of urethral hair post-penoscrotal hypospadias repair
    Sarit Cohen
    Department of Plastic Surgery, Tel Aviv University, Tel Aviv, Israel
    J Cosmet Laser Ther 9:241-3. 2007
    ..Proximal urethral defects account for approximately 20% of hypospadiac urethras. Previous surgical interventions involved hair-bearing genital skin which consequently resulted in a hairy urethra, which is seen mainly in older patients...
  6. pmc Trps1 and its target gene Sox9 regulate epithelial proliferation in the developing hair follicle and are associated with hypertrichosis
    Katherine A Fantauzzo
    Department of Dermatology, Columbia University, New York, NY, USA
    PLoS Genet 8:e1003002. 2012
    ..We have previously demonstrated that a position effect on TRPS1 is associated with hypertrichosis in humans and mice...
  7. pmc X-linked congenital hypertrichosis syndrome is associated with interchromosomal insertions mediated by a human-specific palindrome near SOX3
    Hongwen Zhu
    McKusick Zhang Center for Genetic Medicine and State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China
    Am J Hum Genet 88:819-26. 2011
    X-linked congenital generalized hypertrichosis (CGH), an extremely rare condition characterized by universal overgrowth of terminal hair, was first mapped to chromosome Xq24-q27.1 in a Mexican family...
  8. ncbi Characterization of an in vivo model for the study of eyelash biology and trichomegaly: mouse eyelash morphology, development, growth cycle, and anagen prolongation by bimatoprost
    M Tauchi
    Institute of Anatomy II, University of Erlangen Nuremberg, Erlangen, Germany
    Br J Dermatol 162:1186-97. 2010
    b>Hypertrichosis or alopecia of the eyelashes is associated with various diseases or may be drug induced. Although neither increase nor loss of eyelashes is life threatening, eyelash disorders can be psychologically disturbing...
  9. ncbi SLC29A3 gene is mutated in pigmented hypertrichosis with insulin-dependent diabetes mellitus syndrome and interacts with the insulin signaling pathway
    Simon T Cliffe
    Department of Haematology and Genetics, South Eastern Area Laboratory Services, Sydney, NSW 2031, Australia
    Hum Mol Genet 18:2257-65. 2009
    ..These data suggest that further investigation of the role of SLC29A3 in glucose metabolism is a priority for diabetes research...
  10. ncbi Hypertrichosis lanuginosa congenita
    Vibhu Mendiratta
    Lady Hardinge Medical College, Associated Shrimati Sucheta Kriplani and Kalawati Saran Childrens Hospital, New Delhi, India
    Pediatr Dermatol 25:483-4. 2008
    b>Hypertrichosis lanuginosa congenita is a rare, autosomal dominant cutaneous disorder with sporadic presentations reported...
  11. ncbi Paradoxical hypertrichosis after laser therapy: a review
    Shraddha Desai
    Department of Dermatology, Loyola University, Maywood, Illinois 60563, USA
    Dermatol Surg 36:291-8. 2010
    Laser hair removal is a safe and effective procedure for the treatment of unwanted body hair but is not exempt from side effects. A rare but significant adverse effect with this treatment modality is paradoxical hypertrichosis.
  12. ncbi Hypertrichosis cubiti: two new cases and a review of the literature
    R Visser
    Department of Paediatrics, Spaarneziekenhuis, Haarlem, The Netherlands
    Genet Couns 13:397-403. 2002
    Two cases of hypertrichosis cubiti in combination with short stature, facial dysmorphias and retarded development are reported with a review of the literature...
  13. ncbi Congenital universal hypertrichosis with deafness and dental anomalies inherited as an X-linked trait
    M Tadin-Strapps
    Department of Genetics, Dermatology and Pediatrics, Columbia University, New York, NY, USA
    Clin Genet 63:418-22. 2003
    We report a large Mexican kindred with a variant form of congenital universal hypertrichosis that is inherited in an apparent X-linked recessive manner...
  14. pmc Position effect on FGF13 associated with X-linked congenital generalized hypertrichosis
    Gina M Destefano
    Departments of Genetics and Development, Columbia University, New York, NY, USA
    Proc Natl Acad Sci U S A 110:7790-5. 2013
    X-linked congenital generalized hypertrichosis (Online Mendelian Inheritance in Man 307150) is an extremely rare condition of hair overgrowth on different body sites...
  15. ncbi Multiple exostoses, mental retardation, hypertrichosis, and brain abnormalities in a boy with a de novo 8q24 submicroscopic interstitial deletion
    Wim Wuyts
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    Am J Med Genet 113:326-32. 2002
    ..Here we describe a boy with multiple exostoses, hypertrichosis, mental retardation, and epilepsy due to a de novo deletion on chromosome 8q24...
  16. pmc Copy-number mutations on chromosome 17q24.2-q24.3 in congenital generalized hypertrichosis terminalis with or without gingival hyperplasia
    Miao Sun
    McKusick Zhang Center for Genetic Medicine and State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Am J Hum Genet 84:807-13. 2009
    Congenital generalized hypertrichosis terminalis (CGHT) is a rare condition characterized by universal excessive growth of pigmented terminal hairs and often accompanied with gingival hyperplasia...
  17. ncbi Paradoxical hypertrichosis after laser epilation
    Abdulmajeed Alajlan
    Division of Dermatology, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    J Am Acad Dermatol 53:85-8. 2005
    ..We sought to retrospectively review the prevalence and features of this paradoxical effect...
  18. ncbi Acquired ichthyosis and hypertrichosis due to autoimmune thyroiditis: therapeutic response to thyroxine replacement
    Valeria Brazzelli
    Department of Dermatology, University of Pavia, Policlinico S Matteo IRCCS, Pavia, Italy
    Pediatr Dermatol 22:447-9. 2005
    ..We report a 15-year-old girl with acquired ichthyosis and hypertrichosis associated with hypothyroidism resulting from autoimmune thyroiditis...
  19. ncbi Acromegaloid facial appearance and hypertrichosis: a case suggesting autosomal recessive inheritance
    Paulo R G Zen
    Clin Dysmorphol 13:49-50. 2004
    We report a patient with features of acromegaloid facial appearance syndrome and hypertrichosis. Her parental history suggests an autosomal recessive form of inheritance.
  20. ncbi Hypertrichosis cubiti (hairy elbow syndrome): a clue to a malformation syndrome
    Agata Polizzi
    Department of Paediatrics, University of Catania, National Research Council, Catania, Italy
    J Pediatr Endocrinol Metab 18:1019-25. 2005
    b>Hypertrichosis cubiti (HC) or hairy elbow syndrome (OMIM # 139600) consists of a localised form of long vellus hair on the extensor surfaces of the distal third of the upper arm and the proximal third of the forearm bilaterally, or ..
  21. ncbi Inherited hypertrichoses
    D Garcia-Cruz
    Division de Genetica, Centro de Investigacion Biomedica, Centro Médico de Occidente del Instituto Mexicano del Seguro Social and Centro Universiario Ciencias de la Salud, Universidad de Guadalajara, Mexico
    Clin Genet 61:321-9. 2002
    b>Hypertrichosis is a rare condition characterized by excessive growth of hair (terminal, vellus or lanugo) in areas of the body that are not predominantly androgen dependent, and it is independent of age, race or sex...
  22. ncbi Paraneoplastic hypertrichosis lanuginosa acquisita: uncommon or overlooked?
    P H T J Slee
    Department of Internal Medicine, St Antonius Hospital, PO Box 2500, 3430 EM Nieuwegein, The Netherlands
    Br J Dermatol 157:1087-92. 2007
    Acquired hypertrichosis lanugo-type or hypertrichosis lanuginosa acquisita (HLA) is often associated with metabolic and endocrine disorders and use of certain drugs...
  23. ncbi Hypertrichosis
    Daniel S Wendelin
    St Louis Children s Hospital, I Chiuldren s Place 3N48, St Louis, MO 63110, USA
    J Am Acad Dermatol 48:161-79; quiz 180-1. 2003
    b>Hypertrichosis is hair growth that is abnormal for the age, sex, or race of an individual, or for a particular area of the body. Recognized forms of hypertrichosis are reviewed...
  24. ncbi Fibrous hamartoma of infancy manifesting as multiple nodules with hypertrichosis
    Tae Young Yoon
    Department of Dermatology, College of Medicine, Medical Research Institute, Chungbuk National University, Cheongju, Korea
    J Dermatol 33:427-9. 2006
    ..There have also been a few cases which have showed overlying skin changes, including hypertrichosis and alterations in pigmentation...
  25. ncbi Nevoid hypertrichosis: multiple patches associated with premature graying of lesional hair
    L S Rupert
    Division of Dermatology, Ohio State University, Columbus
    Pediatr Dermatol 11:49-51. 1994
    ..Histologic examination demonstrated terminal hair in otherwise normal skin consistent with nevoid hypertrichosis. The clinical and histologic characteristics of nevoid hypertrichosis are compared with other types of ..
  26. ncbi Nevoid hypertrichosis and hypomelanosis
    Olivia López-Barrantes
    Department of Dermatology, Hospital del Ni o Jes s, Menendez Pelayo 65, 28009 Madrid, Spain
    Eur J Dermatol 12:583-5. 2002
    A girl with multiple lesions of nevoid hypertrichosis and linear hypopigmentation following Blaschko's lines is presented. She had no extracutaneous anomalies...
  27. ncbi Diffuse hypertrichosis and faun-tail naevus as cutaneous markers of spinal dysraphism
    F C Antony
    Department of Dermatology, St Helier Hospital, Surrey, UK
    Clin Exp Dermatol 27:645-8. 2002
    ..two cases of spinal dysraphism where detection of the cutaneous signs - namely a faun-tail naevus and diffuse hypertrichosis - led to early recognition of the occult neurological abnormalities and institution of corrective surgery...
  28. ncbi A boy with mental retardation, obesity and hypertrichosis caused by a microdeletion of 19p13.12
    Nathalie Van der Aa
    Department of Medical Genetics, University of Antwerp, University Hospital Antwerp, Antwerp, Belgium
    Eur J Med Genet 53:291-3. 2010
    We present a moderately mentally retarded boy with obesity, short stature, hypertrichosis and facial dysmorphism due to a deletion of 1.2 Mb on chromosome 19p13.2...
  29. ncbi Giant nevoid hypertrichosis in an Iranian girl
    Raffaella Vergani
    Clinica Dermatologica IV, Universita degli Studi di Milano, Ospedale San Paolo, Milan, Italy
    Pediatr Dermatol 19:64-6. 2002
    ..A physical examination revealed no other abnormalities. In this study the possibility of a genetically determined etiology is considered...
  30. ncbi Hypertrichosis of the eyelashes caused by bimatoprost
    Antonella Tosti
    Department of Dermatology, University of Bologna, Italy
    J Am Acad Dermatol 51:S149-50. 2004
    ..Latanoprost has been shown to stimulate eyelash hypertrichosis and has recently been proposed as a possible treatment for alopecia areata involving the eyelashes...
  31. ncbi Lumbosacral hypertrichosis treated with the normal-mode ruby laser
    Rajini Mahendran
    Acta Derm Venereol 83:142-3. 2003
  32. ncbi Depigmented hypertrichosis following Blaschko's lines associated with cerebral and ocular malformations: a new neurocutaneous, autosomal lethal gene syndrome from the group of epidermal naevus syndromes?
    S Schauder
    Department of Dermatology, Georg August University Goettingen, von Siebold Strasse 3, D 37075 Goettingen, Germany
    Br J Dermatol 142:1204-7. 2000
    ..We describe a 30-year-old man with depigmented, bilateral hypertrichosis and dilated follicular orifices following Blaschko's lines associated with cerebral and ocular malformations...
  33. ncbi Hypertrichosis of vellus hairs of the malar region after unilateral treatment with bimatoprost
    Jeffrey Hart
    Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Ophthalmol 137:756-7. 2004
    To report hypertrichosis and increased pigmentation of vellus hairs of the malar region associated with topical bimatoprost usage.
  34. ncbi Multiple nevoid hypertrichosis as an isolated developmental defect
    Dimitrios Sotiriadis
    Second Dermatologic Clinic, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Pediatr Dermatol 26:436-8. 2009
    ..Clinical diagnosis of patchy nevoid hypetrichosis was confirmed by histology. Nevoid hypertrichosis is a rare hair growth disorder that usually presents at or soon after birth...
  35. ncbi Naevoid hypertrichosis treated with alexandrite laser
    S T Cheung
    Clin Exp Dermatol 29:435-6. 2004
  36. ncbi Gingival overgrowth, congenital generalized hypertrichosis, mental retardation and epilepsy: case report and overview
    Sofia Douzgou
    IRCCS CSS, San Giovanni Rotondo and CSS Mendel Institute, Sapienza University, Rome, Italy
    Clin Dysmorphol 18:205-8. 2009
    We report on a patient with congenital generalized hypertrichosis, mental retardation, tonic-clonic seizures with onset during the first year of life and gingival overgrowth, unrelated to antiepileptic treatment...
  37. ncbi Hypertrichosis of the eyelashes from prostaglandin analog use: a blessing or a bother to the patient?
    M Y Shaikh
    J Ocul Pharmacol Ther 22:76-7. 2006
  38. ncbi Hypertrichosis and increased pigmentation of eyelashes and adjacent hair in the region of the ipsilateral eyelids of patients treated with unilateral topical latanoprost
    M A Johnstone
    Department of Ophthalmology, Swedish Hospital, Medical Center
    Am J Ophthalmol 124:544-7. 1997
    To describe hypertrichosis and increased pigmentation of eyelashes associated with topical latanoprost usage.
  39. ncbi Multiple congenital malformations including generalized hypertrichosis with gum hypertrophy in a child exposed to valproic acid in utero
    C Stoll
    Service de Genetique Medicale, Centre Hospitalo Universitaire, Strasbourg, France
    Genet Couns 14:289-98. 2003
    ..Pregnancy was otherwise uneventful. At birth physical examination showed generalized hypertrichosis sparing palms and soles, coarse face, gum hypertrophy, hypotonia, club feet and club hands, two annular ..
  40. ncbi Acquired trichomegaly of the eyelashes and hypertrichosis induced by bimatoprost
    M I Herane
    J Eur Acad Dermatol Venereol 18:644-5. 2004
  41. ncbi Hypertrichosis terminalis, gingival hyperplasia, and a characteristic face: a new distinct entity
    Sonia Canún
    Division de Genetica, Hospital General Dr Manuel Gea Gonzalez, Mexico City, Mexico
    Am J Med Genet A 116:278-83. 2003
    Congenital generalized hypertrichosis terminalis has been described in association with other features as gingival hyperplasia, osteochondrodysplasia, and a dysmorphic face...
  42. ncbi Hypertrichosis in patients with SURF1 mutations
    Elsebet Ostergaard
    John F Kennedy Institute, Glostrup, Denmark
    Am J Med Genet A 138:384-8. 2005
    We present three patients with SURF1 mutations. In addition to Leigh syndrome all patients had hypertrichosis, a clinical sign that is not usually associated with Leigh syndrome...
  43. ncbi Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris
    Ana Kljuic
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Cell 113:249-60. 2003
    ..We provide evidence that desmoglein 4 is a key mediator of keratinocyte cell adhesion in the hair follicle, where it coordinates the transition from proliferation to differentiation...
  44. ncbi Hypertrichosis in females applying minoxidil topical solution and in normal controls
    R P R Dawber
    Department of Dermatology, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, UK abstract
    J Eur Acad Dermatol Venereol 17:271-5. 2003
    b>Hypertrichosis has been reported more frequently in females than in males who use minoxidil topical solution (MTS) for the treatment of androgenetic alopecia (AGA)...
  45. ncbi Ipsilateral post-cast hypertrichosis and dyshidrotic dermatitis
    C H Chang
    Baylor College of Medicine, Houston, TX
    Arch Phys Med Rehabil 76:97-100. 1995
    Post-cast hypertrichosis and dyshidrotic dermatitis are not uncommon separately. Yet, the simultaneous occurrence of both conditions in an individual is rare...
  46. ncbi Segmental odontomaxillary dysplasia presenting with facial hypertrichosis, commissural lip clefting, and hyperlinear palms
    Lisa J Koenig
    Program in Oral Medicine and Oral Radiology, Department of General Dental Sciences, Marquette University School of Dentistry, Milwaukee, Wisconsin 53201 1881, USA
    Pediatr Dermatol 25:491-2. 2008
    ..is a rare disorder that unilaterally affects the maxilla causing facial asymmetry and presenting with hypertrichosis and hypoplastic or missing teeth in the affected area. Lip clefting has only been reported in one other case...
  47. ncbi A novel mutation in SURF1 causes skipping of exon 8 in a patient with cytochrome c oxidase-deficient leigh syndrome and hypertrichosis
    S L Williams
    University Department of Clinical Neurosciences, Royal Free and University College Medical School, University College London, Rowland Hill Street, London NW3 2PF, United Kingdom
    Mol Genet Metab 73:340-3. 2001
    ..junction of exon 8 of SURF1, in an infant presenting with cytochrome c oxidase-deficient Leigh syndrome and hypertrichosis. cDNA sequencing demonstrated that this deletion results in a messenger lacking exon 8...
  48. ncbi Localized acquired hypertrichosis following cast application
    A Kara
    Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Pediatr Dermatol 18:57-9. 2001
    A 11-year-old boy with transient hypertrichosis following calcaneal osteotomy and cast application for 2 months is described...
  49. ncbi Hypertrichosis universalis congenita: a separate entity, or the same disease as gingival fibromatosis?
    I J Lee
    Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea
    Pediatr Dermatol 10:263-6. 1993
    b>Hypertrichosis universalis congenita is an extremely rare disorder characterized by generalized hypertrichosis. It is generally accepted as being inherited as an autosomal dominant trait with varying expression...
  50. pmc A position effect on TRPS1 is associated with Ambras syndrome in humans and the Koala phenotype in mice
    Katherine A Fantauzzo
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Hum Mol Genet 17:3539-51. 2008
    Ambras syndrome (AS) is a rare form of congenital hypertrichosis with excessive hair on the shoulders, face and ears. Cytogenetic studies have previously implicated an association with rearrangements of chromosome 8. Here we define an 11...
  51. ncbi Neonatal hypertrichosis in an infant of a diabetic mother with congenital hypothyroidism
    M Akcakus
    Department of Pediatrics, School of Medicine, Erciyes University, Kayseri, Turkey
    J Perinatol 26:256-8. 2006
    b>Hypertrichosis in a newborn girl infant of a diabetic mother with congenital hypothyroidism is reported. Both neonatal hyperinsulism and increased testosterone levels were documented...
  52. ncbi Erlotinib-associated trichomegaly
    Katherine Lane
    Oculoplastic Service, Wills Eye Hospital, Jefferson University Hospital Center, Philadelphia, Pennsylvania 19107, USA
    Ophthal Plast Reconstr Surg 23:65-6. 2007
    ..Examination of her ocular adnexa revealed coarse, brittle, irregular aberrant eyelash growth. She has been successfully treated with regular epilation and eyelash trimming and has remained symptom free...
  53. ncbi Pili bigemini and terminal hair growth induced by low-fluence alexandrite laser hair removal
    Iqbal A Bukhari
    Dermatology Department, King Faisal University, College of Medicine, Alkhobar, Saudi Arabia
    J Cutan Med Surg 10:96-8. 2006
    ..Different types of lasers are used in the removal of undesirable hair by targeting the hair follicles, with the melanin pigment acting as the chromophore, and through the mechanism of selective photothermolysis...
  54. ncbi Efficacy of long- and short pulse alexandrite lasers compared with an intense pulsed light source for epilation: a study on 532 sites in 389 patients
    K B Marayiannis
    Laserlight Clinic for Laser and Plastic Surgery, 13 P Stavrou Str, GR 11524 Athens, Greece
    J Cosmet Laser Ther 5:140-5. 2003
    ..The present study retrospectively examined the outcome of these systems from the viewpoint of efficacy and side effects...
  55. ncbi Pneumatic skin flattening (PSF): a novel technology for marked pain reduction in hair removal with high energy density lasers and IPLs
    Gary Lask
    UCLA Medical School, Los Angeles, CA, USA, and LaseOhr Medical Centre, Jerusalem, Israel
    J Cosmet Laser Ther 8:76-81. 2006
    ..There is an interest in a technology which would significantly reduce acute pain and post-treatment erythema, without the necessity of lowering the energy density or speed of treatments...
  56. ncbi Topical prostaglandin F(2alpha) analog induced poliosis
    Celia S Chen
    Department of Ophthalmology, Flinders Medical Centre, Bedford Drive, Bedford Park, Adelaide, SA 5042, Australia
    Am J Ophthalmol 137:965-6. 2004
    ..To report poliosis as a side effect associated with topical prostaglandin F(2alpha) (PGF(2alpha)) analogs...
  57. ncbi Clinical comparison of four hair removal lasers and light sources
    Snehal P Amin
    Skin Laser and Surgery Specialists of NY and NJ, and the Mount Sinai School of Medicine, New York, NY 10022, USA
    J Cosmet Laser Ther 8:65-8. 2006
    ..There are few clinical studies directly comparing the efficacy of multiple hair removal systems in the same individual. This study evaluates the efficacy of four highly popular systems for laser hair removal...
  58. ncbi Incidence and severity of iris pigmentation on latanoprost-treated glaucoma eyes
    S Y Chou
    Department of Ophthalmology, Taipei Veterans General Hospital, National Yang Ming University, Taipei, Taiwan
    Eye (Lond) 19:784-7. 2005
    ..The purpose of the present study was to investigate the incidence and severity of iridial pigmentation under latanoprost topical use on brown eyes in Taiwan...
  59. ncbi Lash ptosis caused by latanoprost
    Robert J Casson
    Glaucoma and Oculoplastic Unit, Department of Ophthalmology, Royal Adelaide Hospital, University of Adelaide, North Terrace, Adelaide, South Australia
    Am J Ophthalmol 139:932-3. 2005
    ..To report a case of lash ptosis caused by latanoprost...
  60. ncbi Prostaglandin-induced hair growth
    Murray A Johnstone
    Glaucoma Consultants Northwest, Swedish Medical Center, Seattle, WA 98104, USA
    Surv Ophthalmol 47:S185-202. 2002
    ..Correlation with laboratory studies suggests that initiation and completion of latanoprost hair growth effects occur very early in anagen and the likely target is the dermal papilla...
  61. ncbi Skin manifestations in a case of trisomy 16 mosaicism
    L B Ousager
    Department of Clinical Genetics, KKA, Odense University Hospital, Sdr Boulevard 29, DK 5000 Odense C, Denmark
    Br J Dermatol 154:172-6. 2006
    We present a 48-year-old man with unilateral dermatological manifestations including hypertrichosis, telangiectasia, hyperkeratosis and hyperpigmentation. Additional findings included skeletal abnormalities and left-sided hearing loss...
  62. ncbi Acquired trichomegaly in uveitis
    Atilla Bayer
    Department of Ophthalmology, GATA Medical School, Ankara, Turkey
    Can J Ophthalmol 42:101-6. 2007
    ..Based on our clinical observations, we examined the relation between trichomegaly and uveitis...
  63. ncbi The phenotypic overlap of syndromes associated with hereditary gingival fibromatosis: follow-up of a family for five years
    M Cenk Haytac
    Department of Periodontology, Cukurova University Faculty of Dentistry, Adana, Turkey
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:521-7. 2007
    ..with HGF and features of 3 previously described syndromes: Jones syndrome, Zimmerman-Laband syndrome, and HGF-hypertrichosis syndrome...
  64. ncbi Evaluation of safety and efficacy of variable pulsed light in the treatment of unwanted hair in 77 volunteers
    H Nahavandi
    Department of Dermatology, Division of Special and Environmental Dermatology, Medical University of Vienna, Vienna, Austria
    J Eur Acad Dermatol Venereol 22:311-5. 2008
    ..The present uncontrolled prospective pilot study evaluated safety and long-term efficacy of variable pulsed light (VPL) on hair removal in the face for medical and/or cosmetic indications...
  65. ncbi [Hypertrichosis]
    R M Trueb
    Dermatologische Klinik, Universitatsspital Zurich, Gloriastrasse 31, 8091 Zurich
    Hautarzt 59:325-37; quiz 338. 2008
    b>Hypertrichosis denotes growth of hair on any part of the body in excess of the amount usually present in persons of the same age, race, and sex, excluding androgen-dependent hair growth...
  66. ncbi Photoepilation: a growing trend in laser-assisted cosmetic dermatology
    Keyvan Nouri
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Cosmet Dermatol 7:61-7. 2008
    ..Conditions such as hirsutism or hypertrichosis, procedures that involve grafted donor sites, transsexual transformations from male to female, and genetics ..
  67. ncbi Paradoxical effects of hair removal systems: a review
    Margarita S Lolis
    Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cosmet Dermatol 5:274-6. 2006
    ..This contradictory hypertrichosis is known as the paradoxical effect...
  68. ncbi Influence of prostaglandin F2alpha and its analogues on hair regrowth and follicular melanogenesis in a murine model
    S Sasaki
    Department of Dermatology, Yamagata University School of Medicine, Iida Nishi, Yamagata, Japan
    Exp Dermatol 14:323-8. 2005
    ..However, they have been reported to have side effects, including hypertrichosis and hyperpigmentation of the eyelashes and periocular skin, and occasionally poliosis...
  69. ncbi [Drug-induced dermatological pathology in renal transplantation patients]
    Tatiana Taranu
    Universitatea de Medicină si Farmacie Gr T Popa Iaşi, Facultatea de Medicina Dentara, Spitalul Universitar C F Iaşi, Clinica Dermatologica
    Rev Med Chir Soc Med Nat Iasi 109:36-9. 2005
    ..5%), oral candidiasis in 6 cases (10.7%), vascular fragility in 5 cases (8.9%), hypertrichosis in 5 cases (8.9%), itching in 3 cases (5.3%), facial erythema in 3 cases (5...
  70. ncbi Segmental odontomaxillary dysplasia. Report of two cases and review of the literature
    Ines Velez
    Nova Southeastern University College of Dental Medicine
    Todays FDA 14:20-1. 2002
    ..The purpose of this article is to describe two cases of segmental odontomaillary dysplasia and summarize the clinical and radiographic findings if the entity after a thorough review of the English literature...
  71. ncbi Comparative evaluation of different hair removal lasers in skin types IV, V, and VI
    Ibrahim Galadari
    Faculty of Medicine and Health Sciences, Dubai, United Arab Emirates
    Int J Dermatol 42:68-70. 2003
    ..Improved clinical results are made possible by the high specificity and selectivity of the laser systems to pigmented hair because of the use of an appropriate wavelength with the proper pulse and duration...
  72. ncbi Hirsutism
    A Mofid
    Department of Internal Medicine, Tehran University of Medical Sciences, Sina Hospital, Tehran, Iran
    Int J Clin Pract 62:433-43. 2008
    ..The current review discusses definition, pathogenesis, differential diagnosis, diagnostic strategies, management, guidelines and the authors' recommendations about hirsutism...
  73. ncbi Diffuse hypertrichosis in the course of hepatitis C treatment by IFN-alpha and ribavirin
    Laurent Misery
    Department of Dermatology, University Hospital, Brest, France
    J Interferon Cytokine Res 22:881-2. 2002
    ..After 6 months, the patient noted a diffuse hair growth, whereas he was beardless before treatment. This hypertrichosis was treated by laser therapy. No hypertrichosis is known in patients with hemophilia or viral hepatitis...
  74. ncbi [Current treatment of hypertrichosis]
    C Kunte
    , , Frauenlobstrasse 9-11,
    Hautarzt 52:993-7. 2001
    Facial hypertrichosis and hirsutism may cause severe cosmetic and psychologic problems. In the following, new developments in the treatment of hypertrichosis will be presented...
  75. ncbi Preferred methods of excess hair removal in pediatric patients with lung transplantation
    Emily J Fisher
    Department of Internal Medicine, Division of Dermatology, Washington University School of Medicine, USA
    J Am Acad Dermatol 55:320-3. 2006
    b>Hypertrichosis is common among recipients of lung transplantation taking cyclosporine and it poses a special psychosocial problem in children. Children and parents frequently inquire about methods of hair removal.
  76. ncbi Depilation in a 6-month-Old with hypertrichosis: A case report
    D S Wendelin
    Washington University School of Medicine, Department of Internal Medicine, St. Louis, Missouri, USA
    Pediatr Dermatol 16:311-3. 1999
    b>Hypertrichosis in the pediatric age group can be troubling to both patients and parents. There is no well-established method for managing this problem in young children...
  77. ncbi Causes and management of hypertrichosis
    Ralph M Trueb
    Department of Dermatology, University Hospital of Zurich, Switzerland
    Am J Clin Dermatol 3:617-27. 2002
    b>Hypertrichosis is the term used for the growth of hair on any part of the body in excess of the amount usually present in persons of the same age, race, and sex, excluding androgen-induced hair growth...
  78. ncbi Further case of Cantú syndrome: exclusion of cryptic subtelomeric chromosome aberrations
    Hartmut Engels
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Am J Med Genet 111:205-9. 2002
    Cantú syndrome consists of hypertrichosis, osteochondrodysplasia, and cardiomegaly, and has been reported in 18 patients to date. We report an infant with Cantú syndrome...
  79. ncbi Cloning of the breakpoints of a de novo inversion of chromosome 8, inv (8)(p11.2q23.1) in a patient with Ambras syndrome
    M Tadin-Strapps
    Department ofDermatology, Columbia University, New York, NY 10032, USA
    Cytogenet Genome Res 107:68-76. 2004
    Ambras syndrome (AMS) is a unique form of universal congenital hypertrichosis. In patients with this syndrome, the whole body is covered with fine long hair, except for areas where normally no hair grows...
  80. ncbi What syndrome is this? Barber-Say syndrome
    Daniela Tenea
    Department of Dermatology, University of Pretoria, Pretoria, Republic of South Africa
    Pediatr Dermatol 23:183-4. 2006
  81. ncbi Anterior cervical hypertrichosis and mental retardation
    Bernard Thienpont
    Center for Human Genetics, University of Leuven, Leuven, Belgium
    Clin Dysmorphol 15:189-90. 2006
    Anterior cervical hypertrichosis or hairy throat is a rare dysmorphic sign described in a total of 19 patients so far. The association with a number of additional features has been reported, including mental retardation...
  82. ncbi Mental retardation in a boy with anterior cervical hypertrichosis
    J Román Corona-Rivera
    Departamento de Fisiologia, Laboratorio de Genética Humana y Clínica de Asesoramiento Genético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, SL, CP 44340 Guadalajara, Jalisco, Mexico
    Am J Med Genet A 135:69-71. 2005
    Anterior cervical hypertrichosis (ACH) is a rare form of localized hypertrichosis with 15 previously reported cases. ACH has been considered to be a dominant phenotype, either X-linked or autosomal [OMIM 600457]...
  83. ncbi Growth hormone deficiency, situs inversus, hypertrichosis and brachydactyly
    Selim Kurtoglu
    Department of Pediatrics, Erciyes University, School of Medicine, Kayseri, Turkey
    J Pediatr Endocrinol Metab 16:795-8. 2003
    ..inversus totalis, short stature, blue sclerae, facial dismorphism, brachydactyly, developmental delay and hypertrichosis. The described phenotype represents a new syndromic situs inversus with a characteristic phenotype...
  84. pmc The H syndrome is caused by mutations in the nucleoside transporter hENT3
    Vered Molho-Pessach
    Department of Dermatology, Hadassah, Hebrew University Medical Center, Jerusalem 91120, Israel
    Am J Hum Genet 83:529-34. 2008
    ..The H syndrome is a recently reported autosomal-recessive disorder characterized by cutaneous hyperpigmentation, hypertrichosis, hepatosplenomegaly, heart anomalies, hearing loss, hypogonadism, short stature, hallux valgus, and fixed ..
  85. ncbi Pigmented hypertrichotic dermatosis and insulin dependent diabetes: manifestations of a unique genetic disorder?
    Julie Prendiville
    Division of Pediatric Dermatology, Department of Pediatrics, British Columbia s Children s Hospital, University of British Columbia Vancouver, Canada
    Pediatr Dermatol 24:101-7. 2007
    ..The pathogenesis is unknown. The presence of consanguinity in three of four families, and similar dysmorphic features in two boys, suggest a genetic disorder, possibly with autosomal recessive inheritance...
  86. ncbi Candidate loci for Zimmermann-Laband syndrome at 3p14.3
    Hyung Goo Kim
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Am J Med Genet A 143:107-11. 2007
    A male with 46,XY,t(3;17)(p14.3;q24.3) presented with gingival hyperplasia, hypertrichosis, unusually large ears and marked hypertrophy of the nose, characteristic of the Zimmermann-Laband syndrome (ZLS)...
  87. ncbi Neuropsychologic side-effects of tacrolimus in pediatric renal transplantation
    Markus J Kemper
    Nephrology Unit, University Children s Hospital and Department of Nephrology, University Hospital, Zurich, Switzerland
    Clin Transplant 17:130-4. 2003
    ..In conclusion, tacrolimus had a beneficial effect on renal function and was well tolerated in the majority of pediatric patients. However, neuropsychologic and behavioral side-effects are important and maybe underrecognized in children...
  88. ncbi Trichomegaly of the eyelashes after treatment with erlotinib in non-small cell lung cancer
    Judith Elizabeth Carser
    Department of Medical Oncology, Northern Ireland Cancer Centre, Belfast, Northern Ireland
    J Thorac Oncol 1:1040-1. 2006
  89. doi Trichomegaly of the eyelashes after lung cancer treatment with the epidermal growth factor receptor inhibitor erlotinib
    Fadi Braiteh
    Department of Investigational Cancer Therapeutics, Phase I Program, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Clin Oncol 26:3460-2. 2008
  90. ncbi Persisting corneal erosion under cetuximab (Erbitux) treatment (epidermal growth factor receptor antibody)
    Claudia G Foerster
    Department of Ophthalmology, University of Erlangen Nuernberg, Erlangen, Germany
    Cornea 27:612-4. 2008
    ..To report persisting corneal erosion and trichomegaly as ocular side effects of cetuximab (Erbitux) treatment, a monoclonal antibody against the epidermal growth factor (EGF) receptor...
  91. ncbi Acquired trichomegaly and symptomatic external ocular changes in patients receiving epidermal growth factor receptor inhibitors: case reports and a review of literature
    Grace Zhang
    Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Cornea 26:858-60. 2007
    ..To report the external ocular changes in 2 patients receiving epidermal growth factor receptor (EGFR) inhibitors...
  92. ncbi Trichomegaly induced by erlotinib
    Rebecca Papadopoulos
    Department of Ophthalmology, Evangelismos Hospital, Athens, Greece
    Orbit 27:329-30. 2008
    ..We present the case of a patient who developed excessive eyelash growth, called trichomegaly, a rare ocular side effect of this drug...
  93. ncbi Comparative tolerability of therapies for ulcerative colitis
    Sandro Ardizzone
    Department of Gastroenterology, L Sacco University Hospital, Milan, Italy
    Drug Saf 25:561-82. 2002
    ..hypertension, opportunistic infections, seizures, paresthesias, tremor, headache, gingival hyperplasia, hypertrichosis, and anaphylaxis with intravenous cyclosporin...
  94. ncbi Spinal dysraphism: trends in northern India
    Raj Kumar
    Department of Neurosurgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Pediatr Neurosurg 38:133-45. 2003
    ..To evaluate the clinical profiles, image findings and surgical outcome of 155 cases of spinal dysraphism...
  95. ncbi X-chromosome inactivation: role in skin disease expression
    Rudolf Happle
    Department of Dermatology, Philipp University of Marburg, Germany
    Acta Paediatr Suppl 95:16-23. 2006
    ..and limb defects) syndrome, and the chequerboard pattern seen in women heterozygous for X-linked congenital hypertrichosis. Exceptional cases of either severe or absent involvement in a woman heterozygous for an X-linked trait can be ..
  96. ncbi Oral cyclosporine in the treatment of inflammatory and noninflammatory dermatoses. A clinical and immunopathologic analysis
    A K Gupta
    Department of Dermatology, University of Michigan Medical School, Ann Arbor
    Arch Dermatol 126:339-50. 1990
    ..Clinical side effects were mild and transient and included dysesthesia, fatigue, hypertrichosis, nausea, and flushing...
  97. ncbi A randomized, placebo-controlled trial of 5% and 2% topical minoxidil solutions in the treatment of female pattern hair loss
    Anne W Lucky
    Dermatology Research Associates Inc, Cincinnati, OH 45230, USA
    J Am Acad Dermatol 50:541-53. 2004
    ..Results can be variable, and historic experience suggests that higher concentrations of topical minoxidil may enhance efficacy...
  98. ncbi Mitchell's influence on European studies of peripheral nerve injuries during World War I
    Peter J Koehler
    Department of Neurology, Atrium Medical Centre, Heerlen, The Netherlands
    J Hist Neurosci 13:326-35. 2004
    ..Describe the influence of S. Weir Mitchell's (1829-1914) work, and in particular his ideas on causalgia, on European physicians who treated peripheral nerve injuries during World War I (WWI)...
  99. ncbi [Efficacy and safety of cyclosporine A in treatment of refractory nephrotic syndrome in children: a systematic review of randomized controlled trials]
    Li Zhi Chen
    Department of Pediatrics, First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Zhonghua Er Ke Za Zhi 47:898-903. 2009
    ..To evaluate the efficacy and safety of cyclosporine A(CsA) in the treatment of refractory nephrotic syndrome (RNS) in children...
  100. ncbi Porphyria cutanea tarda as the most common porphyria
    Vedrana Bulat
    University Department of Dermatology and Venereology, Sestre Milosrdnice University Hospital, Vinogradska cesta 29, HR 10000 Zagreb, Croatia
    Acta Dermatovenerol Croat 15:254-63. 2007
    ..bullae, and milia in sun-exposed areas of the skin, sometimes periorbital mottled hyperpigmentation and hypertrichosis, sclerodermoid changes and ulceration...
  101. ncbi Abnormalities of GH secretion in a young girl with Floating-Harbor syndrome
    S Cannavo
    Chair of Endocrinology, University of Messina, Italy
    J Endocrinol Invest 25:58-64. 2002
    ..Diffused hyperpigmentation and hypertrichosis with sporadic pubic terminal hairs, but neither clitoromegaly nor other signs of hyperandrogenism and/or ..

Research Grants6

  1. Elucidating mitochondrial pathomechanisms of ENT3 disorders in ENT3 KO mice
    Rajgopal Govindarajan; Fiscal Year: 2013
    ..g. scleroderma, hypertrichosis, hallus valgus, short stature, etc.)...
  2. Metabolism-excitation coupling in the heart
    Colin Nichols; Fiscal Year: 2005
    ..The work will provide information that will ultimately underlie the development of rational therapies for the treatment of cardiac ischemia and arrhythmias. ..
  3. FREE PLASMA SEX HORMONE AND ANDROGEN ACTION
    Robert Rosenfield; Fiscal Year: 2001
    ....
  4. The Molecular Basis of Ovarian Testosterone Production
    Robert Rosenfield; Fiscal Year: 2004
    ..The overall goal of this proposal is to understand the factors regulating the production of testosterone in women, particularly in their ovaries. ..
  5. Genetic analysis of congenital diaphragmatic hernia
    Anne Slavotinek; Fiscal Year: 2006
    ..abstract_text> ..
  6. Phase II Clinical Trial Assessing Efficacy and Safety of Oral Steroids vs. Vincri
    Beth Drolet; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..