fibrocystic breast disease

Summary

Summary: A common and benign breast disease characterized by varying degree of fibrocystic changes in the breast tissue. There are three major patterns of morphological changes, including FIBROSIS, formation of CYSTS, and proliferation of glandular tissue (adenosis). The fibrocystic breast has a dense irregular lumpy bumpy consistency.

Top Publications

  1. ncbi Risk factors for benign proliferative breast disease
    C Friedenreich
    Division of Epidemiology, Prevention and Screening, Alberta Cancer Board, 1331 29 St NW, Calgary, Alberta, Canada, T2N 4N2
    Int J Epidemiol 29:637-44. 2000
  2. ncbi Mastopathic fibroadenoma of the breast: a pitfall of aspiration cytology
    I Mori
    Department of Human Pathology, Wakayama Medical University, Wakayama City, Wakayama, Japan
    Cytopathology 17:233-8. 2006
  3. pmc A multi-center prospective cohort study of benign breast disease and risk of subsequent breast cancer
    Geoffrey C Kabat
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, 10461, USA
    Cancer Causes Control 21:821-8. 2010
  4. ncbi Benign breast disorders
    Richard J Santen
    Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, VA, USA
    N Engl J Med 353:275-85. 2005
  5. ncbi Tamoxifen effects on treatment fibrocystic breast disease in women
    Seyed R Mousavi
    Shahid Beheshti Medical Sciences, Shohada Medical Center, Tehran 45672, Iran
    Saudi Med J 27:565-6. 2006
  6. ncbi Differential distribution of soluble and complexed forms of prostate-specific antigen in cyst fluids of women with gross cystic breast disease
    M Malatesta
    Istituto di Istologia and Analisi di Laboratorio, , , Urbino, Italy
    J Clin Lab Anal 15:81-6. 2001
  7. pmc Measurement of prostate-specific antigen in detection of benign or malignant breast disease in women
    J Romppanen
    Department of Clinical Chemistry, Kuopio University Hospital, Finland
    Br J Cancer 79:1583-7. 1999
  8. ncbi Prostate-specific antigen expression in a case of intracystic carcinoma of the breast: characterization of immunoreactive protein and literature surveys
    F Mannello
    Istituto di Istologia ed Analisi di Laboratorio, Facolta di Scienze M F N, Università Studi, Urbino PS, Italy
    Clin Chem 43:1448-54. 1997
  9. ncbi Prostate specific antigen--a new constituent of breast cyst fluid
    E P Diamandis
    Department of Pathology, Mount Sinai Hospital, Toronto, Ontario, Canada
    Breast Cancer Res Treat 38:259-64. 1996
  10. ncbi Distribution and significance of nerve growth factor receptor (NGFR/p75NTR) in normal, benign and malignant breast tissue
    Jorge S Reis-Filho
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Mod Pathol 19:307-19. 2006

Detail Information

Publications154 found, 100 shown here

  1. ncbi Risk factors for benign proliferative breast disease
    C Friedenreich
    Division of Epidemiology, Prevention and Screening, Alberta Cancer Board, 1331 29 St NW, Calgary, Alberta, Canada, T2N 4N2
    Int J Epidemiol 29:637-44. 2000
    ....
  2. ncbi Mastopathic fibroadenoma of the breast: a pitfall of aspiration cytology
    I Mori
    Department of Human Pathology, Wakayama Medical University, Wakayama City, Wakayama, Japan
    Cytopathology 17:233-8. 2006
    ....
  3. pmc A multi-center prospective cohort study of benign breast disease and risk of subsequent breast cancer
    Geoffrey C Kabat
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, 10461, USA
    Cancer Causes Control 21:821-8. 2010
    ....
  4. ncbi Benign breast disorders
    Richard J Santen
    Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, VA, USA
    N Engl J Med 353:275-85. 2005
  5. ncbi Tamoxifen effects on treatment fibrocystic breast disease in women
    Seyed R Mousavi
    Shahid Beheshti Medical Sciences, Shohada Medical Center, Tehran 45672, Iran
    Saudi Med J 27:565-6. 2006
  6. ncbi Differential distribution of soluble and complexed forms of prostate-specific antigen in cyst fluids of women with gross cystic breast disease
    M Malatesta
    Istituto di Istologia and Analisi di Laboratorio, , , Urbino, Italy
    J Clin Lab Anal 15:81-6. 2001
    ..Our results are consistent with the notion that a prolonged exposure of apocrine breast cells lining the Type I gross cysts to the proteolytic activity of PSA could be involved in the etiopathogenesis of GCBD...
  7. pmc Measurement of prostate-specific antigen in detection of benign or malignant breast disease in women
    J Romppanen
    Department of Clinical Chemistry, Kuopio University Hospital, Finland
    Br J Cancer 79:1583-7. 1999
    ..Our results show that serum total PSA cannot be used to distinguish between healthy women and/or women with breast cancer or benign breast disease...
  8. ncbi Prostate-specific antigen expression in a case of intracystic carcinoma of the breast: characterization of immunoreactive protein and literature surveys
    F Mannello
    Istituto di Istologia ed Analisi di Laboratorio, Facolta di Scienze M F N, Università Studi, Urbino PS, Italy
    Clin Chem 43:1448-54. 1997
    ..Our data support the contention that PSA immunoreactivity in intracystic fluid of breast carcinoma is partly the result of secretory activity by the neoplastic cells and that the steroid receptors can also modulate its expression...
  9. ncbi Prostate specific antigen--a new constituent of breast cyst fluid
    E P Diamandis
    Department of Pathology, Mount Sinai Hospital, Toronto, Ontario, Canada
    Breast Cancer Res Treat 38:259-64. 1996
    ..These data suggest that PSA is a frequent component of breast cyst fluid. More studies are needed to establish the role of this serine protease in normal breast, gross breast cystic disease, and breast cancer...
  10. ncbi Distribution and significance of nerve growth factor receptor (NGFR/p75NTR) in normal, benign and malignant breast tissue
    Jorge S Reis-Filho
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Mod Pathol 19:307-19. 2006
    ..Furthermore, provisional data in a small number of basal-like breast carcinomas suggest that NGFR may identify a subgroup of basal-like breast carcinomas with good prognosis...
  11. ncbi Automated image morphometry of lobular breast carcinoma
    Logasundaram Rajesh
    Department of Pathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    Anal Quant Cytol Histol 24:81-4. 2002
    ..To analyze the role of automated image morphometry (AIM) in distinguishing infiltrating lobular carcinoma (ILC) of the breast from benign, borderline and infiltrating ductal carcinoma (IDC)...
  12. ncbi [Differential diagnosis of benign and malignant mammary lesions with special regard to the BI-RADS((R)) classification system in mammography]
    T Boehm
    Departement Medizinische Radiologie, Institut für Diagnostische Radiologie, Universitatsspital Zurich, Schweiz, Switzerland
    Gynakol Geburtshilfliche Rundsch 42:191-200. 2002
    ....
  13. ncbi The gray zone in breast fine needle aspiration cytology. How to report on it?
    Sevgiye Kacar Ozkara
    Department of Pathology, Faculty of Medicine, University of Kocaeli, Izmit, Kocaeli, Turkey
    Acta Cytol 46:513-8. 2002
    ..To study the "gray zone" in breast fine needle aspiration cytology in which an unequivocal diagnosis cannot be reached with fine needle aspiration cytology findings...
  14. ncbi The use of Compton scattering to differentiate between classifications of normal and diseased breast tissue
    Elaine A Ryan
    School of Allied Health Sciences, City University, Charterhouse Square, London EC1M 6PA, UK
    Phys Med Biol 50:3337-48. 2005
    ..The fibrotic nature of tissue that has undergone FCC gives the highest measure of all tissue types...
  15. pmc MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions
    Vasilis Ntziachristos
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104 6059, USA
    Neoplasia 4:347-54. 2002
    ..It is foreseen that the technique can play a major role in functional activation studies of brain and muscle as well...
  16. ncbi [Comparison of wire versus carbon localization of non-palpable breast lesions]
    C C Riedl
    Universitatsklinik fur Radiodiagnostik, Universitat Wien
    Rofo 174:1126-31. 2002
    ..To compare the accuracy of wire and carbon localization in stereotactically localized open breast biopsy...
  17. ncbi [Preoperative wire localisation of breast lesions by tissue harmonic imaging (THI) sonography]
    E M Jung
    Rontgeninstitut des Klinikums Passau
    Rofo 174:1121-5. 2002
    ..To obtain a fast and reliable preoperative wire localisation of occult lesions in dense breast tissue by tissue harmonic imaging (THI) sonography when localisation by mammography is not reliable enough...
  18. ncbi Cytological analysis and immunocytochemical expression of Ki67 and Bcl-2 in breast proliferative lesions
    Cecilia Midulla
    Department of Experimental Medicine and Pathology, University of Rome La Sapienza, Italy
    Anticancer Res 22:1341-5. 2002
    ..Therefore, in our opinion, immunocytochemical Ki67 expression may be helpful in the differentiation of cytologically suspicious/indeterminate breast lesions...
  19. ncbi Mammary hamartoma: report of two cases including one in a male breast, and review of the literature
    Archana Deshpande
    Department of Pathology, Government Medical College, Shankarnagar, Nagpur, Maharashtra, India
    Indian J Pathol Microbiol 47:511-5. 2004
    ..To the best of our knowledge, this is the first case of mammary hamartoma occurring in a male...
  20. ncbi Focal fibrosis of the breast diagnosed by a sonographically guided core biopsy of nonpalpable lesions: imaging findings and clinical relevance
    Jai Kyung You
    Department of Diagnostic Radiology, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun Ku, Seoul 120 752, Korea
    J Ultrasound Med 24:1377-84. 2005
    ..The purpose of this study was to evaluate the frequency of focal fibrosis of the breast diagnosed by a sonographically guided core biopsy of nonpalpable lesions, to characterize imaging features, and to evaluate their clinical relevance...
  21. ncbi Benign breast disease and the risk of breast cancer
    Lynn C Hartmann
    Division of Medical Oncology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    N Engl J Med 353:229-37. 2005
    ..Benign breast disease is an important risk factor for breast cancer. We studied a large group of women with benign breast disease to obtain reliable estimates of this risk...
  22. ncbi Lobular carcinoma in situ diagnosed by core needle biopsy: when should it be excised?
    Lavinia P Middleton
    Department of Pathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mod Pathol 16:120-9. 2003
    ..Based on these findings, we recommend excisional biopsy of lobular carcinoma in situ, atypical lobular hyperplasia or lobular neoplasia only when it is associated with a synchronous mass lesion...
  23. ncbi [Diagnostic immunohistochemistry of breast epithelial lesions]
    André J Balaton
    Centre de Pathologie, 20 avenue de la Gare, 91570 Bièvres
    Ann Pathol 23:570-81. 2003
    ....
  24. ncbi [MRI of the breast. Techniques and current values]
    R Gilles
    Département d Imagerie Médicale, Polyclinique Bordeaux Nord Aquitaine, 15 33, rue Claude Boucher, 33300 Bordeaux, France
    Cancer Radiother 7:115s-119s. 2003
    ..Clinical indication are the diagnosis of local relapses, the evaluation of pre-operative chemotherapy, the diagnosis of an isolated axillary lymphadenopathy, pre-operative evaluation of breast cancer and follow up of breast prothesis...
  25. ncbi [Practical aspects of breast ultrasound]
    K J Biedermann
    Kantonales Frauenspital Fontana, Chur
    Praxis (Bern 1994) 93:707-11. 2004
    ..That's why ultrasound must be combined with clinical findings and other imaging like mammogaphy and MRI to find a reliable diagnosis. A histological work up is indicated if not all the methods show benign findings...
  26. pmc Ultrasound-guided optical tomographic imaging of malignant and benign breast lesions: initial clinical results of 19 cases
    Quing Zhu
    Bioengineering Program, Electrical and Computer Engineering Department, University of Connecticut, Storrs, CT 06269 2157, USA
    Neoplasia 5:379-88. 2003
    ..Furthermore, the small invasive cancers are well localized and have wavelength-dependent appearance in optical absorption maps, whereas the benign lesions appear diffused and relatively wavelength-independent...
  27. ncbi [A comparative analysis of effectiveness of surgical treatment of fibroadenomas in young girls]
    B A Mizaushev
    Vestn Khir Im I I Grek 163:35-9. 2004
    ....
  28. ncbi Accuracy of sonographically guided 14-gauge core-needle biopsy: results of 715 consecutive breast biopsies with at least two-year follow-up of benign lesions
    Pavel Crystal
    Department of Radiology, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, P O B 151, Beer Sheva, 84105, Israel
    J Clin Ultrasound 33:47-52. 2005
    ..The objective of this study was to examine the diagnostic accuracy of sonographically guided 14-gauge core-needle biopsy (CNB)...
  29. ncbi MR mammography in the pre-operative staging of breast cancer in patients with dense breast tissue: comparison with mammography and ultrasound
    M Van Goethem
    Department of Radiology, University Hospital Antwerp, Antwerp, Belgium
    Eur Radiol 14:809-16. 2004
    ..5, 14, and 23%. The MR mammography is more accurate in assessing tumor extent and multifocality in patients with dense breasts, but benign changes may lead to false-positive examinations...
  30. ncbi Technetium-99m-sestamibi scintimammography to detect breast cancer in patients with paraffinomas or siliconomas after breast augmentation
    Nan Jing Peng
    Department of Nuclear Medicine, Kaohsiung Veterans General Hospital, and National Yang Ming University, School of Medicine, Taipei, Taiwan
    Cancer Biother Radiopharm 18:573-80. 2003
    ..The accuracy of scintimammography did not seem to be affected by prior breast augmentation...
  31. ncbi [Evaluation of the primary diagnosis with a CAD-system in mammography]
    A Malich
    Institut für Diagnostische und Interventionelle Radiologie, Friedrich Schiller Universitat Jena
    Rofo 175:1225-31. 2003
    ..To assess the capability of the computer assisted detection (CAD) system to classify calcifications that are histologically verified as malignant and benign or are proven benign by magnification and follow up mammography...
  32. ncbi Pathologic quiz case: a cystic breast mass. Cystic hypersecretory hyperplasia with cytologic atypia
    Xian feng Zhao
    Division of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Arch Pathol Lab Med 127:e389-90. 2003
  33. ncbi [Interventional radiology in nonpalpable lesions of the breast]
    A Tardivon
    Service de Radiologie, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05
    J Radiol 84:381-6. 2003
    ..Clear information to the patients, efficient quality control and multidisciplinary approach are mandatory for the success of these percutaneous diagnostic procedures...
  34. ncbi Technetium-99m sestamibi in the diagnosis of breast cancer. The Mayagüez Medical Center experience
    J Farías-Jimenez
    General Surgery Department, Dr Ramón E Betances Hospital, Mayaguez Medical Center, Puerto Rico
    Bol Asoc Med P R 93:9-11. 2001
    ..5% and 100%, respectively). So, Scintimammography may be a complement for current diagnostic techniques for breast malignancy in our setting...
  35. ncbi Use of prior mammograms in the classification of benign and malignant masses
    Celia Varela
    Radboud University Medical Centre Nijmegen, Department of Radiology, Geert Grooteplein 18, 6525 GA Nijmegen, The Netherlands
    Eur J Radiol 56:248-55. 2005
    ..The mean area under the ROC curve of the readers increased from 0.763 to 0.796. This difference in performance was statistically significant (P = 0.008)...
  36. ncbi In vivo real-time freehand palpation imaging
    Timothy J Hall
    Department of Radiology, University of Kansas Medical Center, Kansas City, KS, USA
    Ultrasound Med Biol 29:427-35. 2003
    ..In addition, a comparison of the lesion area measured in B-mode vs. strain images, for a representative image from the sequence, appears to be a sensitive criterion for separating invasive ductal carcinoma from cyst and fibroadenoma...
  37. ncbi Original report. Mucocele-like tumors of the breast: mammographic and sonographic appearances
    Katrina Glazebrook
    Department of Radiology, Mayo Clinic, 200 First St S W, Rochester, MN 55905, USA
    AJR Am J Roentgenol 180:949-54. 2003
    ..The purpose of our study was to describe the mammographic and sonographic appearances of the mucocele-like tumor of the breast...
  38. ncbi Benign breast disease
    Douglas J Marchant
    Department of Obstetrics and Gynecology and Surgery, Tufts University School of Medicine, USA
    Obstet Gynecol Clin North Am 29:1-20. 2002
    ..For most patients with breast symptomatology, the goal is relief of symptoms and resolution of the problem. To accomplish this requires a contemporary knowledgebase combined with adequate time spent with the patient...
  39. ncbi [Values of color Doppler flow imaging and imaging changes of breast fascia and ligament in differential diagnosis of small breast neoplasms]
    Hui Zeng
    State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P R China
    Ai Zheng 25:339-42. 2006
    ..This study was to explore the value of combined use of CDFI and imaging changes of breast fascia and ligament in differential diagnosis of small breast neoplasms...
  40. ncbi Breast lumps in the adolescent female
    Paige Johnson
    Department of Medical Breast Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Pediatr Health Care 16:43, 47-8. 2002
  41. ncbi Computer aided classification system for breast ultrasound based on Breast Imaging Reporting and Data System (BI-RADS)
    Wei Chih Shen
    Department of Computer Science and Information Engineering, National Chung Cheng University, Chiayi, Taiwan, R O C
    Ultrasound Med Biol 33:1688-98. 2007
    ..To classify the mass into BI-RADS assessment categories by the CAC system is feasible. Moreover, the proposed CAC system is flexible because it can be used to diagnose the cases acquired from different ultrasound systems...
  42. ncbi Diagnostic utility of p75 neurotrophin receptor (p75NTR) as a marker of breast myoepithelial cells
    Nikolay K Popnikolov
    Department of Pathology and Laboratory Medicine, College of Medicine, Drexel University, Philadelphia, PA 19146, USA
    Mod Pathol 18:1535-41. 2005
    ..Our data suggest a role of neurotrophins in the development of fibroepithelial breast tumors and some of the breast carcinomas...
  43. ncbi The diagnosis and management of diabetic mastopathy
    Katie Thorncroft
    Department of Surgery, Royal Liverpool University Hospital, Liverpool, United Kingdom
    Breast J 13:607-13. 2007
    ..Detailed Pubmed and other medical data base searches were carried out and all publications were considered, irrespective of language and date, wherever possible...
  44. ncbi [About mastopathy]
    Péter Göblyös
    Uzsoki utcai Kórház Onkoradiológiai Központ Budapest Bogdánfy u 5 a 1117
    Orv Hetil 148:2211-8. 2007
    ..The most important tools are close observation, systematic care of patients by a team of professionals, possibly by the same persons, in the same institute. Further research, and more exact definitions are necessary...
  45. doi Vacuum assisted stereotactic guided mammotome biopsies in the management of screen detected microcalcifications: experience of a large breast screening centre
    V Kumaroswamy
    Department of Histopathology and Molecular Pathology, Leeds Teaching Hospitals, Leeds, UK
    J Clin Pathol 61:766-9. 2008
    ..To evaluate the usefulness of vacuum assisted stereotactic guided mammotome biopsy in the diagnostic management of screen detected calcifications and to rationalise its use versus diagnostic excision...
  46. doi Adenosis tumor of the breast: cytological and radiological features of a case confirmed by histology
    Nadra El Aouni
    Department of Medical Biology and Pathology, Institut Gustave Roussy, Villejuif, France
    Diagn Cytopathol 36:496-8. 2008
    ..A core needle biopsy performed to rule out a breast cancer revealed an adenosis tumor of the breast...
  47. doi Automated breast ultrasound: lesion detection and BI-RADS classification--a pilot study
    E Wenkel
    Radiologisches Institut, Universitatsklinikum Erlangen
    Rofo 180:804-8. 2008
    ..Evaluation of an automated breast ultrasound system (ABUS) regarding the detection and classification of breast lesions according to BI-RADS...
  48. ncbi Cytologic differential diagnosis of papillary pattern in breast aspirates: correlation with histology
    R Nayar
    Division of Cytopathology and the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago IL, USA
    Ann Diagn Pathol 5:34-42. 2001
    ..Ann Diagn Pathol 5:34-42, 2001...
  49. pmc Altered coagulability: an aid to selective breast biopsy
    C R Spillert
    Department of Surgery, UMDNJ New Jersey Medical School, Newark 07103 2757
    J Natl Med Assoc 85:273-7. 1993
    ..The amount of tissue factor release is contingent on prior activation of the monocyte (the only blood cell that generates tissue factor) in vivo...
  50. ncbi A review of breast ultrasound
    Chandra M Sehgal
    Silverstein, Department of Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Mammary Gland Biol Neoplasia 11:113-23. 2006
    ..In the future, ultrasound will play a greater role in differentiating benign from malignant masses and in the diagnosis of breast cancer...
  51. ncbi Bracketing wires for preoperative breast needle localization
    L Liberman
    Department of Radiology, Breast Imaging Section, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    AJR Am J Roentgenol 177:565-72. 2001
    ..Bracketing wires may assist the surgeon in achieving complete excision of calcifications, but bracketing wires do not ensure clear histologic margins of resection...
  52. ncbi An uncommon case of diabetic mastopathy in type II non-insulin dependent diabetes mellitus
    Keiichi Sotome
    Department of Surgery, Fussa Hospital, Fussa City, Tokyo, Japan
    Breast Cancer 13:205-9. 2006
    ..These lymphocytes were composed predominantly of B-cells. Five months after surgical biopsy, a nodular formation approximately 4 cm in diameter recurred adjacent to the resected end of the biopsy...
  53. ncbi A case of mucinous spherulosis of the breast diagnosed retrospectively in FNA material
    Juan B Laforga
    Servicio de Anatomia Patologica, Hospital Marina Alta, Ptda Plana Est, Denia Alicante, Spain
    Diagn Cytopathol 34:626-30. 2006
    ..We draw attention to the importance of recognizing these features because they can easily pose problems either by being overlooked or overdiagnosed as mucinous carcinoma. Differential diagnosis is briefly discussed...
  54. ncbi Improved reporting methods for atypia and atypical ductal hyperplasia in breast core needle biopsy specimens. Potential for interlaboratory comparisons
    A A Renshaw
    Dept of Pathology, Baptist Hospital of Miami, 8900 N Kendall Dr, Miami, FL 33176, USA
    Am J Clin Pathol 116:87-91. 2001
    ..This method of reporting atypia may allow interlaboratory comparisons with less dependence on the characteristics of the patient population...
  55. ncbi Diagnostic value of 99mTc MIBI scintimammography in patients with breast lesions
    A Yildiz
    Akdeniz University, Faculty of Medicine, Department of Nuclear Medicine, Antalya, Turkey
    Rev Esp Med Nucl 20:276-81. 2001
    ..We concluded that 99mTc-MIBI scintimammography could be a valuable method in the differentiation of malignant breast neoplasm larger than 1 cm size from benign ones, especially when the uptake pattern was considered...
  56. ncbi Fine needle aspiration cytology of sclerosing adenosis of the breast
    E Y Cho
    Department of Diagnostic Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-gu, Seoul 135-710, Korea
    Acta Cytol 45:353-9. 2001
    ..Awareness of the presence of scattered individual epithelial cells in cytologic smears of sclerosing adenosis can help prevent a misdiagnosis of malignancy...
  57. ncbi MR-Guided vacuum biopsy of 206 contrast-enhancing breast lesions
    C Perlet
    Institut fur Klinische Radiologie, Klinikum der Universität Grosshadern, Munchen, Germany
    Rofo 174:88-95. 2002
    ..To determine the accuracy and clinical use of MR-guided vacuum biopsy (VB) of enhancing breast lesions...
  58. ncbi [Ultrasound mammography]
    K J Biedermann
    Kantonales Frauenspital Fontana, Chur
    Praxis (Bern 1994) 90:767-72. 2001
    ..Therefore the diagnosis has to be evaluated by combining clinical and imaging analysis but final diagnosis remains for histological examination...
  59. ncbi [Effects of stereotaxic puncture biopsy on breast diagnosis in a general hospital]
    N Reutter

    Rontgenpraxis 54:26-34. 2001
    ..An increasing acceptance by the gynecologists doing open biopsies could lead to a further decrease of unnecessary operations. The effect by direct histologic feedback improves the quality of mammographic diagnostic...
  60. doi Electrolytes and trace elements in human breast cyst fluid
    Ali Riza Sisman
    Department of Biochemistry, Faculty of Medicine, Dokuz Eylul University, Inciralti, Izmir, Turkey
    Biol Trace Elem Res 128:18-30. 2009
    ..615, p = 0.014, respectively). We can conclude that the trace elements content of BCF, in addition to electrolytes, could be useful in classifying the breast cyst. Future studies in larger series are needed to confirm these data...
  61. doi Breast disease in children and adolescents in eastern Nigeria--a five-year study
    B C Ozumba
    Department of Radiation Medicine, Provost, College of Medicine, University of Nigeria, Enugu, Nigeria
    J Pediatr Adolesc Gynecol 22:169-72. 2009
    ..1) To define the spectrum of breast diseases in the children and adolescents in Eastern Nigeria. (2) To provide where possible, an international comparison of statistical variations of both benign and malignant lesions in these age groups...
  62. ncbi Prostatic acid phosphatase in breast cyst fluid
    Hakan Erbas
    Department of Biochemistry, Faculty of Medicine, University of Trakya, Edirne, Turkey
    Malays J Pathol 29:95-9. 2007
    ..The presence of PAP in BCF may suggest its possible role in the development of breast cancer from cystic breast diseases. A possible role of PAP on TGF-beta activation needs further investigation...
  63. ncbi Issues of regret in women with contralateral prophylactic mastectomies
    L L Montgomery
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg Oncol 6:546-52. 1999
    ..We have developed a National Prophylactic Mastectomy Registry comprised of a volunteer population of 817 women from 43 states who have undergone prophylactic (unilateral or bilateral) mastectomy...
  64. ncbi Melatonin and estrogen in breast cyst fluids
    James B Burch
    Cancer Prevention and Control Program, Center for Colon Cancer Research, WJB Dorn Veterans Affairs Medical Center, Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC 29208, USA
    Breast Cancer Res Treat 103:331-41. 2007
    ..Melatonin and estrogen in BCF independently predicted growth inhibition and stimulation, respectively. Biological monitoring of BCF may help identify women with GCBD at greatest risk for breast cancer development...
  65. ncbi Metabolic control through L calcium channel, PKC and opioid receptors modulation by an association of naloxone and calcium salts
    P Minoia
    Department of Animal Production Physiology Reproduction Surgery, University of Bari, Italy
    Curr Drug Targets Immune Endocr Metabol Disord 1:131-7. 2001
    ....
  66. pmc Relationship between epidermal growth factor and dehydroepiandrosterone and its sulphate in breast cyst fluid
    L C Lai
    Department of Chemical Pathology, St Mary s Hospital Medical School, London, UK
    Br J Cancer 60:320-3. 1989
    ..A positive correlation was also obtained between DHA and DHAS concentrations which supports the view that DHA in cyst fluid may be derived from the metabolism of DHAS in the breast cyst wall...
  67. ncbi Serum prolactin and growth hormone determined by radioimmunoassay and a two-site immunoradiometric assay: comparison with the Nb2 cell bioassay
    D P Rose
    Division of Nutrition and Endocrinology, Naylor Dana Institute for Disease Prevention, Valhalla, New York
    Horm Metab Res 20:49-53. 1988
    ..High BA, but normal RIA results, giving mean ratios of 2.4 +/- 1.1 and 3.6 +/- 3.0 respectively, suggest the presence of a further variant with high bioactivity not detected by RIA in these two clinical situations...
  68. doi Nasal seromucinous hamartoma (microglandular adenosis of the nose): a morphological and molecular study of five cases
    Andrea Ambrosini-Spaltro
    Sezione di Anatomia Istologia e Citologia Patologica Marcello Malpighi, Dipartimento di Oncologia ed Ematologia, Universita di Bologna, Ospedale Bellaria, Bologna, Italy
    Virchows Arch 457:727-34. 2010
    ..It is concluded that nasal seromucinous hamartomas are benign glandular proliferations that may resemble microglandular adenosis of the breast. Their distinction from benign and malignant mimics is discussed...
  69. ncbi Profile of a menopause clinic in an urban population in Malaysia
    P Damodaran
    Department of Obstetrics and Gynaecology, and Nuclear Medicine, University Hospital, Lembah Pantai, Kuala Lumpur 59100, Malaysia
    Singapore Med J 41:431-5. 2000
    ..There were 2 cases of intraductal carcinoma diagnosed on routine mammography, with 8 cases of fibrocystic breast disease and 7 cases of suspicious breast lumps...
  70. ncbi Immunohistochemical expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) in invasive breast carcinoma
    Suada Kuskunovic
    Institute of Pathology, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
    Bosn J Basic Med Sci 9:125-30. 2009
    ..with invasive ductal carcinoma, 10 with invasive lobular carcinoma, and 10 specimens from patients with fibrocystic breast disease. TIMP-1 protein was immunodetected in the carcinoma cells, fibroblasts and inflammatory cells of the ..
  71. ncbi Germline mutations in PTEN and SDHC in a woman with epithelial thyroid cancer and carotid paraganglioma
    Kevin M Zbuk
    Genomic Medicine Institute at the Cleveland Clinic, Cleveland, OH, USA
    Nat Clin Pract Oncol 4:608-12. 2007
    ..There was no family history of malignancy. Past medical history includes uterine leiomyoma and fibrocystic breast disease. Physical examination revealed macrocephaly and papillomatous papules.
  72. doi Young-aged woman with invasive ductal carcinoma arising in atypical microglandular adenosis: a case report
    Yi Hsuan Lee
    Department of Pathology, Chia Yi Christian Hospital, Chia Yi, Taiwan
    Pathol Int 60:685-9. 2010
    ..This report is of practical interest because the diagnosis of AMGA and MGACA had already been made via needle biopsy...
  73. doi Concomitant administration of simvastatin and danazol associated with fatal rhabdomyolysis
    Ivan Stankovic
    Department of Cardiology, Clinical Hospital Centre Zemun, Belgrade, Serbia
    Clin Ther 32:909-14. 2010
    ..Danazol is a steroid analogue approved for the treatment of endometriosis, fibrocystic breast disease, and hereditary angioedema...
  74. ncbi Molecular mediators of tumor angiogenesis: enhanced expression and activation of vascular endothelial growth factor receptor KDR in primary breast cancer
    A Kranz
    Department of Internal Medicine II, Ulm University Medical Center, Germany
    Int J Cancer 84:293-8. 1999
    ..We investigated a total of 13 mammary carcinomas, 3 fibroadenomas, 5 specimens with fibrocystic breast disease as well as normal (adjacent to malignant) breast tissue using immunohistochemistry and Western blot ..
  75. ncbi Unilateral breast enlargement 5 years after reduction mammaplasty
    Petra Pülzl
    Department of Plastic and Reconstructive Surgery, University Hospital Innsbruck, Anichstrasse, 35, A 6020 Innsbruck, Austria
    Aesthetic Plast Surg 29:404-6. 2005
    ..Histologic examination confirmed the diagnosis of a fibrocystic breast disease in both breasts...
  76. ncbi Recent mammography use among African-American women
    Y Cozier
    Slone Epidemiology Unit, Boston University School of Medicine, Brookline, Massachusetts 02446, USA
    Ethn Dis 11:188-91. 2001
    ..We assessed recent mammography use in a large national study, the Black Women's Health Study...
  77. ncbi Contribution of thyroid gland ultrasound for screening of patients with suspected subclinical thyroid gland disorders
    M Tajtakova
    Ist Dpt of Internal Medicine, Faculty of Medicine, Safarikiensis University, Kosice, Slovakia
    Bratisl Lek Listy 100:196-9. 1999
    ..contractility, increased diastolic pressure, hypercholesterolemia, menstrual abnormalities, infertility, fibrocystic breast disease, anxiety, insomnia, tachycardia, paroxysmal atrial fibrillation and osteoporosis...
  78. ncbi Facial hirsutism following danazol therapy
    Vijay Zawar
    Skin Disease Centre, Maharashtra, India
    Cutis 74:301-3. 2004
    ..She had been treated for fibrocystic breast disease with danazol for 6 months...
  79. ncbi Focal fibrosis of the breast diagnosed by core needle biopsy under imaging guidance
    Cholatip Wiratkapun
    Department of Radiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    J Med Assoc Thai 96:340-5. 2013
    ..Concordance with the pathology result from core needle biopsy (CNB) and follow-up are essential to avoid false negative...
  80. doi Age and associated fibrocystic changes are prognostically significant in patients with small node-negative (T1a,bN0) invasive breast cancer
    Merih Guray Durak
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Breast J 17:462-9. 2011
    ..Age at diagnosis and associated FCC are significant factors in predicting recurrence in patients with T1a,bN0 IBC. Adjuvant systemic therapy should be discussed with and considered for young patients with T1a,bN0 IBC...
  81. ncbi Benign breast pain in women: a practical approach to evaluation and treatment
    Frances E Norlock
    Cook County Hospital, USA
    J Am Med Womens Assoc 57:85-90. 2002
    ..Some investigations did find associations between breast pain and premenstrual syndrome, fibrocystic breast disease, and caffeine intake...
  82. ncbi Histomorphological spetrum of breast lesions
    S Parajuli
    Kathmandu Model Hospital, Nepal
    J Nepal Health Res Counc 9:48-51. 2011
    ..All breast lumps are considered to be carcinomas until proved otherwise and are the causes of concern both for the patient and surgeon...
  83. doi Sclerotic fibroma (storiform collagenoma)-like stroma in a fibroadenoma of axillary accessory breast tissue
    Jose Fernando Val-Bernal
    Anatomical Pathology Department, Marques de Valdecilla, University Hospital, Medical Faculty, University of Cantabria and IFIMAV, Santander, Spain
    J Cutan Pathol 39:798-802. 2012
    ..The lesion should be differentiated from extraneural perineuroma, from the changes in fibroadenomas in Cowden's syndrome, from sclerosing lobular hyperplasia (fibroadenomatoid mastopathy) and from pseudoangiomatous stromal hyperplasia...
  84. ncbi Atypical ductal hyperplasia of the breast diagnosed by ultrasonographically guided core needle biopsy
    H H Hsu
    Department of Radiology, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Ultraschall Med 33:447-54. 2012
    ..We analysed the ultrasonographic (US) features of atypical ductal hyperplasia (ADH) of the breast diagnosed by US-guided core needle biopsy (CNB) with the aim of identifying factors that affect the underestimation of ADH...
  85. ncbi Distribution of phthalocyanines and Raman reporters in human cancerous and noncancerous breast tissue as studied by Raman imaging
    Beata Brozek-Pluska
    Technical University of Lodz, Institute of Applied Radiation Chemistry, Laboratory of Laser Molecular Spectroscopy, Wroblewskiego 15, 93 590 Lodz, Poland
    Technol Cancer Res Treat 11:317-31. 2012
    ..We conclude that the Raman imaging reported here has a potential to be a novel and effective photodynamic therapeutic method with improved selectivity for the treatment of breast cancer...
  86. doi Computer-aided diagnosis of breast masses using quantified BI-RADS findings
    Woo Kyung Moon
    Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea
    Comput Methods Programs Biomed 111:84-92. 2013
    ..90 vs. 0.76, p<0.05). In conclusion, the computer-aided analysis with qualitative information from radiologists showed a promising result for breast tumor classification...
  87. doi Therapeutic application of ultrasound-guided 8-gauge Mammotome system in presumed benign breast lesions
    Hao Jun Luo
    Department of General Surgery, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China
    Breast J 17:490-7. 2011
    ..It is a reliable biopsy tool for suspected lesions as well. Eradication and maximal cosmesis can be achieved with few complications if the targeted lesion is limited to 30 mm...
  88. doi Endometrial cancer in a 14-year-old girl with Cowden syndrome: a case report
    William David Baker
    Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah 84132, USA
    J Obstet Gynaecol Res 39:876-8. 2013
    ..She subsequently developed fibrocystic breast disease and colon polyps and was diagnosed with Cowden syndrome at age 20...
  89. doi Is hyperandrogenemia protective for fibrocystic breast disease in PCOS?
    Enis Ozkaya
    Department of Obstetrics and Gynecology, Dr Sami Ulus Women s Health Teaching and Research Hospital, Ankara, Turkey
    Gynecol Endocrinol 28:468-71. 2012
    The aim of this study is to evaluate the fibrocystic breast disease rates and its association with different clinical, endocrine and metabolic parameters between main polycystic ovary syndrome (PCOS) phenotypes...
  90. pmc Cyclooxygenase-2 inhibitor inhibits hippocampal synaptic reorganization in pilocarpine-induced status epilepticus rats
    Hai Ju Zhang
    Department of Pediatrics, Renmin Hospital of Wuhan University, Wuhan 430060, China
    J Zhejiang Univ Sci B 9:903-15. 2008
    ..To examine modulations caused by cyclooxygenase-2 (COX-2) inhibitors on altered microenvironments and overbalanced neurotransmitters in pilocarpine-induced epileptic status rats and to investigate possible mechanisms...
  91. ncbi Extratumoral breast tissue in breast cancer patients: a multinational study of variations with age and country of residence in low- and high-risk countries. WHO Collaborative Study of Neoplasia and Steroid Contraceptives
    T B Aaman
    Institute of Medical Biology, University of Tromso, Norway
    Int J Cancer 71:333-9. 1997
    ..They also suggest a delayed progression from noninvasive to invasive carcinoma in low-risk countries...
  92. doi Differential diagnosis between sclerosing adenosis and tubular carcinoma of the breast under transmission and scanning electron microscope
    George E Baltatzis
    Research Centre G Papanikolaou, St Savas Anticancer Hospital, Athens, Greece
    Ultrastruct Pathol 35:226-9. 2011
    ..The aim of this study is to prove that the ultrastructure results can give the correct diagnosis between tubular carcinoma and sclerosing adenosis...
  93. ncbi Cytogenetics of benign breast lesions
    C Lundin
    Department of Clinical Genetics, Uppsala University Hospital, Sweden
    Breast Cancer Res Treat 51:1-15. 1998
    ..The potential tumor suppressor gene(s) in this region remains, however, to be identified...
  94. doi Benign breast disease among first-degree relatives of young breast cancer patients
    Lisbeth Bertelsen
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Am J Epidemiol 168:261-7. 2008
    ..A genetic link between benign breast disease and breast cancer was indicated by our data but needs to be confirmed in future studies...
  95. ncbi [Android obesity and breast cancer risk]
    Cynthia Petrovanu
    Disciplina de Medicină de Ambulator, Facultatea de Medicina, Universitatea de Medicină şi Farmacie Gr T Popa, Iasi
    Rev Med Chir Soc Med Nat Iasi 111:872-6. 2007
    ..Carmichael and Bates showed an inverse relationship between BMI and perimenopausal breast cancer...
  96. ncbi Differentiation of benign and malignant breast tumors by logistic regression and a classification tree using Doppler flow signals
    W Sauerbrei
    Institute of Medical Biometry and Informatics, University of Freiburg, Germany
    Methods Inf Med 37:226-34. 1998
    ..The results indicate that the estimates of sensitivity and specificity are probably close to realistic values for a clinical setting...
  97. ncbi Regression of the fibrous disease of the breast in a non-diabetic woman after pregnancy and breastfeeding
    Maria Aparecida Q F Pereira
    Service of Mastology, Hospital de Base do Distrito Federal, Brasilia, DF, Brazil
    Arq Bras Endocrinol Metabol 51:1539-43. 2007
    ..Once a definitive diagnosis of this pathology is reached, it is recommended clinical, imaging studies and fine-needle aspiration biopsy follow-up of the patient, avoiding unnecessary surgical procedures...
  98. ncbi Allopregnanolone, pregnenolone sulfate, and epitestosterone in breast cyst fluid
    M Bicikova
    Institute of Endocrinology, Narodni 8, 116 94 Praha 1, Prague, Czech Republic
    Steroids 66:55-7. 2001
    ..Pregnenolone-sulfate levels in BCF were about two orders of magnitude higher when compared with the circulation. No differences were found in concentrations of the steroids studied between the types of cysts...
  99. ncbi Apocrine adenosis of the breast: clonal evidence of neoplasia
    Y Endoh
    Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan
    Histopathology 38:221-4. 2001
    ..We report here a case of apocrine adenosis of the breast in a 66-year-old woman. To clarify the nature of this lesion, we examined it by clonal analysis...
  100. doi An Immunohistochemical study of HER-2 expression in feline mammary tumours
    R Rasotto
    Department of Public Health, Comparative Pathology and Veterinary Hygiene, University of Padua, Italy
    J Comp Pathol 144:170-9. 2011
    ..These results suggest that HER-2 may not play as significant role in mammary carcinogenesis and prognosis in cats as it does in human patients...
  101. pmc Comparative analysis of the expression patterns of metalloproteinases and their inhibitors in breast neoplasia, sporadic colorectal neoplasia, pulmonary carcinomas and malignant non-Hodgkin's lymphomas in humans
    A E Kossakowska
    Department of Pathology, University of Calgary, Alberta, Canada
    Br J Cancer 73:1401-8. 1996
    ..However, MMP-11 expression is a characteristic of tumours of epithelial origin that is not found in lymphoid neoplasia. Thus it suggests that MMP-11 may play a regulatory role in the invasion and metastasis of carcinomas...

Research Grants88

  1. Human Gut Microflora Profiling for Population Studies
    Johanna Lampe; Fiscal Year: 2006
    ..abstract_text> ..
  2. BREAST CANCER AND GENE POLYMORPHISMS IN CHINESE WOMEN
    Chu Chen; Fiscal Year: 2003
    ..Our ultimate goal is to provide information to identify women at high risk of breast cancer, and to aid in the formulation of prevention strategies for these women. ..
  3. Molecular Epidemiology of Endometrial Cancer
    Chu Chen; Fiscal Year: 2007
    ..Efforts will also be devoted to generating risk indices through statistical modeling that integrate potential effects of genetic variants in the estrogen metabolism pathway and/or DNA repair pathways. ..
  4. MOLECULAR EPIDEMIOLOGY OF LUNG CANCER
    Chu Chen; Fiscal Year: 2007
    ..g. Rosaceae fruits and Cruciferae vegetables), and food-derived nutrients (e.g. carotenoids, vitamin C, and vitamin E). ..
  5. ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMES
    Chu Chen; Fiscal Year: 2007
    ..As such, this proposal is highly responsive to the recommendations made by the NCI Head and Neck Cancer 1999 Priority Setting Workshop (http://www.nci.nih.gov/disease-initiative/headneckcancer). ..
  6. MOLECULAR EPIDEMIOLOGY OF LUNG CANCER
    Chu Chen; Fiscal Year: 2010
    ..g. Rosaceae fruits and Cruciferae vegetables), and food-derived nutrients (e.g. carotenoids, vitamin C, and vitamin E). ..
  7. ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMES
    Chu Chen; Fiscal Year: 2010
    ..HPV plays an important etiologic role in some oropharyngeal cancers, we plan to determine and incorporate HPV genotypes in the analyses and interpretation of the study findings. ..
  8. ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMES
    Chu Chen; Fiscal Year: 2009
    ..HPV plays an important etiologic role in some oropharyngeal cancers, we plan to determine and incorporate HPV genotypes in the analyses and interpretation of the study findings. ..
  9. Fast Optical Imager for tumor detection
    Xavier Intes; Fiscal Year: 2005
    ..abstract_text> ..
  10. Flow-mediated dilation by ultrasound imaging
    Chandra Sehgal; Fiscal Year: 2006
    ....
  11. Breast and Bone Density: Impact of Colonic Environment
    Johanna Lampe; Fiscal Year: 2006
    ..If equol-producer phenotype can predict differences in cumulative estrogen exposure / metabolism, it may serve as an early marker of breast cancer risk. ..
  12. UNDERSTANDING VARIABILITY IN COMMUNITY MAMMOGRAPHY
    Joann Elmore; Fiscal Year: 2007
    ..This work builds on our previous model development and is a natural extension in a timely and important clinical area. ..
  13. Quantitative Mechanical Imaging for Improving Breast Ultrasound Diagnosis
    Timothy J Hall; Fiscal Year: 2010
    ..The resulting calibrated 3D strain images and images of elastic nonlinearity also show promise for directly imaging ductal carcinoma in situ, thereby potentially improving early detection of breast cancer. ..
  14. Validation of Sensorized Breast Models for High-Stakes Clinical Skills Assessment
    Carla M Pugh; Fiscal Year: 2010
    ..Our results will help set clinical performance standards. ..
  15. Role of CCN6 (WISP3) in the progression and metastasis of breast cancer
    Celina Kleer; Fiscal Year: 2009
    ..These studies may form the basis of intervention and therapy in breast cancer, potentially preventing premalignant lesions from becoming malignant and metastasizing. ..
  16. Role of EZH2 in Breast Cancer
    Celina Kleer; Fiscal Year: 2009
    ..In summary, this proposal addresses the clinical utility and functional role of EZH2 in the regulation of breast cancer progression. ..
  17. Whole body tomography of fluorescent proteins in vivo
    Vasilis Ntziachristos; Fiscal Year: 2007
    ....
  18. DETERMINANTS OF TISSUE ESTRADIOL SENSITIVITY
    Richard Santen; Fiscal Year: 2009
    ..FTS, a novel mTOR inhibitor will be used in vitro to activate the stress kinase pathway and apoptosis. In vivo, FTS will be used to enhance estradiol induced apoptosis in nude mice. ..
  19. Accuracy of Breast Pathology and the Impact of Technology & Double Reading
    DONALD LEE WEAVER; Fiscal Year: 2010
    ..We will also evaluate the impact of double reading and new technology that digitizes images of slides on overall accuracy. ..
  20. UCSF-KAISER WOMEN'S HEALTH INTERDISCIPLINARY SCHOLARSHIP
    Deborah Grady; Fiscal Year: 2004
    ..Our goal is to create a model national resource for training successful investigators in women's health. ..
  21. Hormone Status Postmenopause: Colonic Bacterial Effects
    Johanna Lampe; Fiscal Year: 2003
    ..The results of this study will provide novel data regarding the relationship of the equol-producer phenotype, a marker of colonic nticrofloral environment, to lifetime estrogen exposure. ..
  22. A New Biomarker for Ovarian Cancer Detection
    Eleftherios Diamandis; Fiscal Year: 2003
    ..In this grant proposal, we describe further studies, which will examine in greater detail, the ability of a test for the amount of this protein in blood to correctly diagnose the presence of ovarian cancer. ..
  23. Serum IGFs--Effects of a Soy Intervention in Humans
    Johanna Lampe; Fiscal Year: 2002
    ..It provides an ideal design to evaluate the effects of isoflavones on the IGF system and to explore relationships between IGFs and colonic epithelial cell proliferation in humans. ..
  24. HOST GENES AND COLONIC BACTERIA--PROBING FOR INHERITANCE
    Johanna Lampe; Fiscal Year: 2002
    ..If we can establish that the equol-producer phenotype is an inherited trait, we can then work to identify the associated genotype and determine more effectively whether this is a biomarker of breast cancer risk. ..
  25. Hybrid optical-ultrasound scanner for cancer imaging
    Vasilis Ntziachristos; Fiscal Year: 2005
    ..abstract_text> ..
  26. DNA Damage: Fruit & Vegetable Effects in a Feeding Trial
    Johanna Lampe; Fiscal Year: 2005
    ..The existing intervention provides an ideal design in which to evaluate the relationships between biotransformation enzyme systems and DNA damage in humans. ..
  27. Human Kallikrein 4 (hK4): A New Prostatic Biomarker?
    Eleftherios Diamandis; Fiscal Year: 2003
    ..If successful, our research will contribute to the development of new prostatic biomarkers and possibly, to better diagnosis which may lead to better clinical outcomes and reduced healthcare costs. ..
  28. Accuracy of Breast Pathology and the Impact of Technology & Double Reading
    Joann Elmore; Fiscal Year: 2009
    ..We will also evaluate the impact of double reading and new technology that digitizes images of slides on overall accuracy. ..
  29. Glucuronidation in Humans--Genotypes and Phenotypes
    Johanna Lampe; Fiscal Year: 2004
    ..The randomized cross-over design will allow us to test efficiently for diet effects within individuals, as well as for gene-by-diet and sex-by-diet interactions. ..
  30. Hybrid Complete Protection Flourescence Molecular Tomography and X-ray CT
    Ralph Weissleder; Fiscal Year: 2007
    ..We hypothesize that the proposed developments will yield a practical and highly efficient system that can become a method of choice in many preclinical studies involving in-vivo imaging of entire animals. ..
  31. Near Infrared Diffused Light Imaging with Ultrasound Guidance
    Quing Zhu; Fiscal Year: 2007
    ..Approximately 40 patients who will undergo chemotherapy treatments will be recruited to this pilot study from both institutions. ..
  32. ADVANCES IN OPTICS FOR BIOTECHNOLOGY, MEDICINE
    Vasilis Ntziachristos; Fiscal Year: 2005
    ..Aim 4: To promote interaction between the invited scientists and participating students, to support education and understanding of the multi-disciplinary field of bio-optics and associated applications and to enable collaborations. ..
  33. DETERMINANTS OF TISSUE ESTRADIOL SENSITIVITY
    Richard Santen; Fiscal Year: 1999
    ....
  34. Mammographic Density and Invasive Breast Cancer
    Etta Pisano; Fiscal Year: 2006
    ....
  35. DOXYCYCLINE FOR BLEEDING IN PROGESTIN ONLY CONTRACEPTORS
    David Archer; Fiscal Year: 2006
    ..If successful, DOX treatment could become an important adjuvant for treatment of this and possibly other inflammatory disorders effecting reproductive tract tissues. ..
  36. Blood Flow in Small Animals by Ultrasound
    Chandra Sehgal; Fiscal Year: 2006
    ..abstract_text> ..
  37. UGT Polymorphisms and Hormonally-Mediated Biomarkers in Premenopausal Women
    Johanna Lampe; Fiscal Year: 2007
    ..Resulting data will be used to guide future, larger, population-based studies of genetic differences in steroid hormone metabolism and may ultimately be used to identify women who are more susceptible to hormone-related conditions. ..
  38. EGCG and Omega-3 Fatty Acids Impact on Fatty Acid Synthase Activity in the Prosta
    Jackilen Shannon; Fiscal Year: 2007
    ..The elucidation of a single oncogenic pathway that may be regulated by diet may provide a new and exciting opportunity for targeted prevention therapy. ..
  39. Palpation Imaging
    Timothy Hall; Fiscal Year: 2007
    ..The result of this effort will be a clinically useful tool for examining the mechanical response of human tissues, and a set of training tools to allow the skilled ultrasound clinician to efficiently learn to use these new tools. ..
  40. Doppler Vascularity/Sonography--Breast Cancer Diagnosis
    Chandra Sehgal; Fiscal Year: 2005
    ..An integrated approach in which one mode represents tissue property and the other its function will result in a systematic and comprehensive diagnosis of breast cancers. ..
  41. Near Infrared Diffused Light Imaging with Ultrasound Guidance
    Quing Zhu; Fiscal Year: 2009
    ..Approximately 40 patients who will undergo chemotherapy treatments will be recruited to this pilot study from both institutions. ..