giant cell tumor of bone

Summary

Summary: A bone tumor composed of cellular spindle-cell stroma containing scattered multinucleated giant cells resembling osteoclasts. The tumors range from benign to frankly malignant lesions. The tumor occurs most frequently in an end of a long tubular bone in young adults. (From Dorland, 27th ed; Stedman, 25th ed)

Top Publications

  1. ncbi [Giant cell tumor of bone with rapid malignant course]
    M R Lachat
    Klinik für Rheumatologie und Rehabilitation, Stadtspital Triemli, Zurich, Switzerland
    Orthopade 33:344-8. 2004
  2. ncbi The origin of the neoplastic stromal cell in giant cell tumor of bone
    Manuela Wülling
    Department of Bone Pathology Center of Biomechanics, University Hospital Hamburg Eppendorf, Germany
    Hum Pathol 34:983-93. 2003
  3. ncbi Giant cell tumor of the extremity: A review of 349 cases from a single institution
    Costantino Errani
    Musculoskeletal Oncology Department, Istituto Ortopedico Rizzoli, Bologna, Italy
    Cancer Treat Rev 36:1-7. 2010
  4. pmc A short-term in vivo model for giant cell tumor of bone
    Maurice Balke
    Department of Trauma and Orthopedic Surgery, University of Witten Herdecke, Cologne Merheim Medical Center, Ostmerheimer Str, Cologne, Germany
    BMC Cancer 11:241. 2011
  5. ncbi Giant cell tumor of the extremity: retrospective analysis of 621 Chinese patients from one institution
    Xiaohui Niu
    Department of Orthopedic Oncology Surgery, Beijing Ji Shui Tan Hospital, Peking University, 31 Xinjiekou East Street, Xicheng District, Beijing 100035, China
    J Bone Joint Surg Am 94:461-7. 2012
  6. pmc A case of recurrent giant cell tumor of bone with malignant transformation and benign pulmonary metastases
    Ira J Miller
    Department of Orthopedic Surgery, Rush University Medical Center, 1611 W, Harrison 300 Chicago, IL, 60612, USA
    Diagn Pathol 5:62. 2010
  7. ncbi Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 study
    David Thomas
    Peter MacCallum Cancer Centre, East Melbourne, Vic, Australia
    Lancet Oncol 11:275-80. 2010
  8. ncbi Giant cell tumor of bone. The role of fibroblast growth factor 3 positive mesenchymal stem cells in its pathogenesis
    Dror Robinson
    Department of Orthopedics A Assaf Harofeh Medical Center, Zerifin, Israel
    Pathobiology 70:333-42. 2002
  9. ncbi Giant cell tumor of bone: a basic science perspective
    Robert W Cowan
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Bone 52:238-46. 2013
  10. pmc Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone
    Sam Behjati
    1 Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK 2 Department of Paediatrics, University of Cambridge, Cambridge, UK 3
    Nat Genet 45:1479-82. 2013

Detail Information

Publications235 found, 100 shown here

  1. ncbi [Giant cell tumor of bone with rapid malignant course]
    M R Lachat
    Klinik für Rheumatologie und Rehabilitation, Stadtspital Triemli, Zurich, Switzerland
    Orthopade 33:344-8. 2004
    ..Following the diagnosis of giant cell tumor of bone (GCT) on biopsy and curettage, a rapid malignant course was observed with recurrence 2.5 months later...
  2. ncbi The origin of the neoplastic stromal cell in giant cell tumor of bone
    Manuela Wülling
    Department of Bone Pathology Center of Biomechanics, University Hospital Hamburg Eppendorf, Germany
    Hum Pathol 34:983-93. 2003
    Fibroblastlike stromal cells, which are always present as a component of giant cell tumor of bone (GCT), can be observed in both in vivo and cultured cell samples...
  3. ncbi Giant cell tumor of the extremity: A review of 349 cases from a single institution
    Costantino Errani
    Musculoskeletal Oncology Department, Istituto Ortopedico Rizzoli, Bologna, Italy
    Cancer Treat Rev 36:1-7. 2010
    ..Special attention must be given to giant cell tumors not only in the distal radius, but also in the proximal femur, where the treatment is more difficult and associated with a higher rate of local recurrence...
  4. pmc A short-term in vivo model for giant cell tumor of bone
    Maurice Balke
    Department of Trauma and Orthopedic Surgery, University of Witten Herdecke, Cologne Merheim Medical Center, Ostmerheimer Str, Cologne, Germany
    BMC Cancer 11:241. 2011
    Because of the lack of suitable in vivo models of giant cell tumor of bone (GCT), little is known about its underlying fundamental pro-tumoral events, such as tumor growth, invasion, angiogenesis and metastasis...
  5. ncbi Giant cell tumor of the extremity: retrospective analysis of 621 Chinese patients from one institution
    Xiaohui Niu
    Department of Orthopedic Oncology Surgery, Beijing Ji Shui Tan Hospital, Peking University, 31 Xinjiekou East Street, Xicheng District, Beijing 100035, China
    J Bone Joint Surg Am 94:461-7. 2012
    ..The present study was designed to review the epidemiological characteristics and outcomes of surgical management in a large series of Chinese patients with giant cell tumor of an extremity, treated at a single institution...
  6. pmc A case of recurrent giant cell tumor of bone with malignant transformation and benign pulmonary metastases
    Ira J Miller
    Department of Orthopedic Surgery, Rush University Medical Center, 1611 W, Harrison 300 Chicago, IL, 60612, USA
    Diagn Pathol 5:62. 2010
    ..Here we report a case of GCT of bone that at the time of recurrence was found to have undergone malignant transformation. Concurrent metastases were found in the lung, but these were non-transformed GCT...
  7. ncbi Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 study
    David Thomas
    Peter MacCallum Cancer Centre, East Melbourne, Vic, Australia
    Lancet Oncol 11:275-80. 2010
    ..We investigated the potential therapeutic effect of denosumab, a fully human monoclonal antibody against RANKL, on tumour-cell survival and growth in patients with GCT...
  8. ncbi Giant cell tumor of bone. The role of fibroblast growth factor 3 positive mesenchymal stem cells in its pathogenesis
    Dror Robinson
    Department of Orthopedics A Assaf Harofeh Medical Center, Zerifin, Israel
    Pathobiology 70:333-42. 2002
    b>Giant cell tumor of bone is typified by massive infiltration of a bland neoplastic stroma by osteoclasts and monocyte progenitors...
  9. ncbi Giant cell tumor of bone: a basic science perspective
    Robert W Cowan
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Bone 52:238-46. 2013
    Comprehending the pathogenesis of giant cell tumor of bone (GCT) is of critical importance for developing novel targeted treatments for this locally-aggressive primary bone tumor...
  10. pmc Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone
    Sam Behjati
    1 Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK 2 Department of Paediatrics, University of Cambridge, Cambridge, UK 3
    Nat Genet 45:1479-82. 2013
    ..Gly34Arg or p.Gly34Val alterations in childhood brain tumors, a remarkable picture of tumor type specificity for histone H3.3 driver alterations emerges, indicating that histone H3.3 residues, mutations and genes have distinct functions. ..
  11. ncbi Giant cell tumor of bone: review, mimics, and new developments in treatment
    Corey J Chakarun
    Department of Radiology, Keck School of Medicine, University of Southern California, 1500 San Pablo St, 2nd Floor Imaging, Los Angeles, CA 90033 5313, USA
    Radiographics 33:197-211. 2013
    ..Denosumab, a monoclonal antibody that targets the osteoclastic activity of GCT, has produced 90% tumor necrosis in early studies, results indicative of promise as a potential adjuvant therapy...
  12. pmc Can p63 serve as a biomarker for giant cell tumor of bone? A Moroccan experience
    Nawal Hammas
    Department of Pathology, Hassan II University Hospital, Harazem, Fez, Morocco
    Diagn Pathol 7:130. 2012
    ..Differential diagnosis can be challenging, particularly in instances of limited sampling. The purpose of this study was to evaluate the contribution of the P63 in the positive and differential diagnosis of giant cell tumor of bone.
  13. ncbi Giant cell tumor of bone
    Kevin A Raskin
    Massachusetts General Hospital, Boston, MA, USA
    J Am Acad Orthop Surg 21:118-26. 2013
    ..Medical therapy and radiotherapy can alter the management of GCT of bone, especially in multifocal disease, local recurrences, and bulky central/axial disease...
  14. pmc Modern interpretation of giant cell tumor of bone: predominantly osteoclastogenic stromal tumor
    Yuhree Kim
    Department of Orthopaedic Surgery, Columbia University Medical Center, Columbia University, New York, NY 10032, USA
    Clin Orthop Surg 4:107-16. 2012
    ..Consistent with this paradigm, a recombinant RANK-Fc protein and bisphosphonates are currently being tried for GCT treatment in addition to surgical excision and conventional topical adjuvant therapies...
  15. ncbi Giant cell tumor of bone
    Alan W Yasko
    Department of Orthopedic Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 444, Houston, TX 77030, USA
    Curr Oncol Rep 4:520-6. 2002
    b>Giant cell tumor of bone is an enigmatic osseous neoplasm that is histologically benign but clinically shows local aggression and metastatic potential...
  16. ncbi The treatment of sacral giant-cell tumours by serial arterial embolisation
    R D Lackman
    Department of Orthopaedic Surgery, The Hospital of the University of Pennsylvania, Philadelphia 19104, USA
    J Bone Joint Surg Br 84:873-7. 2002
    ..They remained free from growth, recurrence, or metastases at follow-up (4 to 17 years). One patient died from metastatic disease within 18 months of the initial diagnosis...
  17. pmc Which treatment is the best for giant cell tumors of the distal radius? A meta-analysis
    Yu Peng Liu
    Department of Orthopaedics, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, PR China
    Clin Orthop Relat Res 470:2886-94. 2012
    ..However, it is unclear whether one provides lower rates of recurrences and fewer complications, and whether the use of polymethylmethacrylate (PMMA) after curettage reduces the risk of recurrence...
  18. ncbi RANK (receptor activator of nuclear factor kappa B) and RANK ligand are expressed in giant cell tumors of bone
    Sophie Roux
    Rheumatology Department, Bicetre Hospital, Le Kremlin Bicetre, France
    Am J Clin Pathol 117:210-6. 2002
    ..Our results suggest that RANKL expression may have a role in the pathogenesis of GCTBs and in the formation of the large OC population present in these tumors...
  19. pmc Identification of potential biomarkers for giant cell tumor of bone using comparative proteomics analysis
    Amalia Conti
    Laboratory of Experimental Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy
    Am J Pathol 178:88-97. 2011
    b>Giant cell tumor of bone can be locally aggressive and occasionally can metastasize in the lungs...
  20. ncbi Factors of local recurrence of giant cell tumor of long bone after treatment: plain radiographs, pathology and surgical procedures
    Kullanuch Chanchairujira
    Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University Bangkok, Thailand
    J Med Assoc Thai 94:1230-7. 2011
    ..To evaluate the relationship between local recurrence of giant cell tumor (GCT) after surgical treatments and plain radiography, pathology grade and surgical procedures...
  21. ncbi Phenol as an adjuvant for local control in the treatment of giant cell tumour of the bone
    H R Dürr
    Department of Orthopedics and Orthopedic Surgery, Ludwig Maximilians University Munich, Klinikum Grosshadern, Marchioninistr 15, Munich, D 81366, Germany
    Eur J Surg Oncol 25:610-8. 1999
    ..Due to the combined use of phenol and cementation in most studies, the effect of phenol alone is described in this study...
  22. pmc A clinicopathological study of giant cell tumor of small bones
    Michiro Yanagisawa
    Department of Orthopedic Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Ups J Med Sci 116:265-8. 2011
    ..The purpose of this study was to investigate and report the clinicopathological features of 11 cases with small-bone GCT...
  23. ncbi Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of bone
    Isabella W Y Mak
    McMaster University, Hamilton, Ontario, Canada L8V 5C2
    Hum Pathol 41:1320-9. 2010
    b>Giant cell tumor of bone (GCT) is an aggressively osteolytic primary bone tumor that is characterized by the presence of abundant multinucleated osteoclast-like giant cells, hematopoietic monocytes, and a distinct mesenchymal stromal cell ..
  24. ncbi Upregulation of MMP-13 via Runx2 in the stromal cell of Giant Cell Tumor of bone
    Isabella W Y Mak
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    Bone 45:377-86. 2009
    b>Giant Cell Tumor of bone (GCT) is an aggressively osteolytic and cytokine-rich bone tumor...
  25. ncbi Properties of the stromal cell in giant cell tumor of bone
    Michelle Ghert
    McMaster University, Hamilton Health Sciences and the Juravinski Cancer Centre, Hamilton, Ontario, Canada
    Clin Orthop Relat Res 459:8-13. 2007
    ..The spindle like stromal cells of GCT have characteristics of osteoblast progenitors and produce active matrix-degrading proteases. These cells may therefore play a central role in bone destruction...
  26. pmc Cathepsin K is the principal protease in giant cell tumor of bone
    Jan H N Lindeman
    Department of Biomedical Research, TNO Prevention and Health, PO Box 2215, 2301 CE Leiden, The Netherlands
    Am J Pathol 165:593-600. 2004
    ..Inhibition of cathepsin K or its associated proton-pump may provide new therapeutic opportunities for GCT...
  27. ncbi Expression of preosteoblast markers and Cbfa-1 and Osterix gene transcripts in stromal tumour cells of giant cell tumour of bone
    L Huang
    Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, China
    Bone 34:393-401. 2004
    ..In summary, our data suggest that GCT stromal tumour cells may have an osteoblastic lineage and retain the ability to differentiate into osteoblasts...
  28. ncbi Local recurrence of giant cell tumor of bone after intralesional treatment with and without adjuvant therapy
    Wolfgang T Becker
    Orthopädische Klinik Volmarstein, Universitat Witten Herdecke, Wetter, Germany
    J Bone Joint Surg Am 90:1060-7. 2008
    The use of adjuvants after curettage has been well established for the treatment of giant cell tumor of bone. The purpose of this study was to analyze the rates of recurrence following different types of treatment as well as the influence ..
  29. ncbi Giant cell tumor of bone express p63
    Brendan C Dickson
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada
    Mod Pathol 21:369-75. 2008
    ..The purpose of this study was to investigate p63 expression in giant cell tumor of bone and to determine whether it can be used to discriminate between other giant cell-rich tumors...
  30. ncbi Intralesional curettage for grades II and III giant cell tumors of bone
    Richard D Lackman
    University of Pennsylvania, Philadelphia, PA 19106 6192, USA
    Clin Orthop Relat Res 438:123-7. 2005
    ....
  31. ncbi Morphological and immunophenotypic features of primary and metastatic giant cell tumour of bone
    M Alberghini
    Istituto Ortopedico Rizzoli, Bologna, Italy
    Virchows Arch 456:97-103. 2010
    ..Our findings suggest that most lung nodules associated with primary conventional GCTBs are implants derived from tumour emboli formed in areas of haemorrhage and thrombus formation within the primary tumour...
  32. pmc Histologically verified lung metastases in benign giant cell tumours--14 cases from a single institution
    M Dominkus
    University Clinic of Vienna, Department of Orthopaedics, Allgemeines Krankenhaus der Stadt Wien, Vienna, Austria
    Int Orthop 30:499-504. 2006
    ..We conclude that even metastatic benign giant cell tumours have an excellent prognosis after adequate resection. No prognostic factors despite high-grade lesions were detectable...
  33. ncbi CCAAT/enhancer binding protein beta is up-regulated in giant cell tumor of bone and regulates RANKL expression
    Patrick Kwok Shing Ng
    School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR
    J Cell Biochem 110:438-46. 2010
    ....
  34. pmc Histogenetic characterization of giant cell tumor of bone
    Manuela Salerno
    Laboratory for Pathophysiology, Istituto Ortopedico Rizzoli, 40136 Bologna, Italy
    Clin Orthop Relat Res 466:2081-91. 2008
    ..The increased number of giant cells in GCT may be secondary to an autocrine circuit mediated by the receptor activator of nuclear factor kB...
  35. ncbi Functional outcome of en bloc excision and osteoarticular allograft replacement with the Sauve-Kapandji procedure for Campanacci grade 3 giant-cell tumor of the distal radius
    Robert M Szabo
    Department of Orthopaedic Surgery, School of Medicine, University of California, Davis, Sacramento, 95817, USA
    J Hand Surg Am 31:1340-8. 2006
    ..The purpose of this study was to assess with validated patient outcome surveys the intermediate to long-term outcomes of all patients treated with this surgery and to analyze their functional results and document tumor control...
  36. ncbi Treatment options for recurrent giant cell tumors of bone
    Maurice Balke
    Department of Orthopedic Surgery, University of Muenster, Albert Schweitzer Str 33, 48149, Munster, Germany
    J Cancer Res Clin Oncol 135:149-58. 2009
    ..The possible surgical procedures range from repeated intralesional curettage to wide resection...
  37. ncbi Giant cell tumor of bone: treatment and outcome of 214 cases
    Maurice Balke
    Department of Orthopedic Surgery, University of Muenster, Muenster, Germany
    J Cancer Res Clin Oncol 134:969-78. 2008
    Two hundred and fourteen patients with benign giant cell tumor of bone (GCTB), treated from 1980 to 2007 at the Department of Orthopedics of the University of Muenster (Germany), were analyzed in a retrospective study.
  38. ncbi Similarities between giant cell tumor of bone, giant cell tumor of tendon sheath, and pigmented villonodular synovitis concerning ultrastructural cytochemical features of multinucleated giant cells and mononuclear stromal cells
    Ukei Anazawa
    Department of Orthopaedic Surgery, Keio University, School of Medicine, Tokyo, Japan
    Ultrastruct Pathol 30:151-8. 2006
    ..investigated ultrastructural cytochemical features of multinucleated and mononuclear stromal cells in giant cell tumor of bone (GCTB), giant cell tumor of tendon sheath (GCTTS), and pigmented villonodular synovitis (PVNS)...
  39. ncbi Techniques in the management of juxta-articular aggressive and recurrent giant cell tumors around the knee
    S Vidyadhara
    Department of Orthopaedics, Kasturba Medical College, Manipal, Udupi, Karnataka 576 104, India
    Eur J Surg Oncol 33:243-51. 2007
    ..Juxta-articular aggressive and recurrent giant cell tumors around the knee pose difficulties in management. This article reviews current problems and options in the management of these giant cell tumors...
  40. pmc Metastatic giant cell tumor of bone: are there associated factors and best treatment modalities?
    Seethalakshmi Viswanathan
    Department of Pathology, Tata Memorial Hospital, Parel, Mumbai 400012, India
    Clin Orthop Relat Res 468:827-33. 2010
    ..None of the patients died of their metastatic disease. None of the risk factors we studied was associated with metastasis in giant cell tumors. Although the overall outcome was favorable, metastasectomy is recommended where feasible...
  41. ncbi Impact severity of local recurrence in giant cell tumor of bone
    Richard L McGough
    From the University of Texas M D Anderson Cancer Center, Department of Orthopaedic Oncology, Houston, TX
    Clin Orthop Relat Res 438:116-22. 2005
    ..Despite its benign histology, giant cell tumor of bone is an aggressive tumor that demands meticulous attention to surgical detail and close postoperative ..
  42. ncbi Giant cell tumour of bone
    David M Thomas
    Departments of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Curr Opin Oncol 21:338-44. 2009
    ..Giant cell tumour of bone (GCT) is the most common benign bone tumour and afflicts a young population. Treatment options for patients with unresectable disease have remained fairly static for the past three decades...
  43. pmc Giant cell tumour of the sacrum: a suggested algorithm for treatment
    Rajkumar Thangaraj
    The Royal Orthopaedic Hospital Oncology Service, Bristol Road South, Birmingham, B31 2AP, UK
    Eur Spine J 19:1189-94. 2010
    ..Embolisation and curettage are the preferred first option with radiotherapy as a possible adjunct. Spinopelvic fusion may be needed when the sacrum collapses...
  44. ncbi Features of grade 3 giant cell tumors of the distal radius associated with successful intralesional treatment
    Lana Kang
    Department of Orthopaedics, Division of Hand and Upper Extremity, Hospital for Special Surgery, 523 East 72nd Street, New York, NY 10021, USA
    J Hand Surg Am 35:1850-7. 2010
    ..The goal of this study was to identify radiographic and anatomic features of Campanacci grade 3 distal radius giant cell tumors that are associated with an acceptable rate of local recurrence after intralesional treatment...
  45. ncbi Clonality studies in giant cell tumor of bone
    H S Schwartz
    Vanderbilt University, Department of Orthopaedics and Rehabilitation, Nashville, Tennessee 37232 2550, USA
    J Orthop Res 20:387-90. 2002
    ..Seventeen female patients with giant cell tumor of bone had their DNA harvested and their X-chromosome inactivation pattern and polymorphisms determined and ..
  46. ncbi [Factors related to biologic behavior in giant cell tumor of bone]
    Xiang Ying Ran
    Department of Pathology, Shanghai Jiaotong University Affiliated the Sixth People s Hospital, Shanghai 200233, China
    Zhonghua Bing Li Xue Za Zhi 42:669-74. 2013
    ..To study the histogenesis of giant cell tumor (GCT) and factors related to tumor recurrence, invasiveness and malignant transformation...
  47. ncbi Long-term outcome of giant cell tumors of bone around the knee treated by en bloc resection of tumor and reconstruction with prosthesis
    Xiu Chun Yu
    Department of Orthopaedics, The General Hospital of Jinan Military Commanding Region, Jinan, China
    Orthop Surg 2:211-7. 2010
    ..To study the long-term outcomes and complications of giant cell tumors around the knee treated with en bloc resection and reconstruction with prosthesis...
  48. pmc Giant cell tumor of bone: are we stratifying results appropriately?
    Thomas J Kremen
    Department of Orthopaedic Surgery, University of California Los Angeles Medical Center, Box 956902, 76 143 CHS, Los Angeles, CA, USA
    Clin Orthop Relat Res 470:677-83. 2012
    There is no consensus as to which surgical approach to the treatment of giant cell tumor of bone is most appropriate or which patients are at a higher risk for recurrence or metastasis.
  49. ncbi RANKL, denosumab, and giant cell tumor of bone
    David M Thomas
    Department of Cancer Medicine, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia
    Curr Opin Oncol 24:397-403. 2012
    ..Giant cell tumor (GCT) of bone is a benign, osteolytic neoplasm of bone. The receptor activator of NF-KB ligand (RANKL) pathway has recently been shown to play a key role in the pathogenesis of GCT...
  50. ncbi Stro-1(+) stromal cells have stem-like features in giant cell tumor of bone
    Jie Lan
    Department of Orthopaedics, Peking University Third Hospital, Beijing, People s Republic of China
    J Surg Oncol 106:826-36. 2012
    b>Giant cell tumor of bone (GCTB) is an aggressive benign bone tumor with poor prognosis whose neoplastic component is stromal cells (SCs). Tumor stem-like cells (TSCs) have been demonstrated as precursors for tumor genesis and growth...
  51. ncbi MicroRNA expression profiles in metastatic and non-metastatic giant cell tumor of bone
    Neda Mosakhani
    Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Histol Histopathol 28:671-8. 2013
    b>Giant cell tumor of bone (GCTB) is a skeletal neoplasm, a locally aggressive tumor that occasionally metastasizes to the lungs...
  52. ncbi p63 expression in giant cell-containing lesions of bone and soft tissue
    Gustavo de la Roza
    Department of Pathology, Upstate University Hospital, Syracuse, New York, USA
    Arch Pathol Lab Med 135:776-9. 2011
    ..Although routine histology is often all that is required to diagnose giant cell tumor of bone, immunohistochemistry could prove useful to distinguish it from other benign and malignant giant cell-..
  53. ncbi The efficacy of chemical adjuvants on giant-cell tumour of bone. An in vitro study
    Y Gortzak
    Mount Sinai Hospital, Toronto, Canada
    J Bone Joint Surg Br 92:1475-9. 2010
    ..No multinucleated cell formation was seen in these cultures. These results suggest that the use of chemical adjuvants other than water could help improve local control in the treatment of GCT of bone...
  54. ncbi Regulation of MMP-9 (92 kDa type IV collagenase/gelatinase B) expression in stromal cells of human giant cell tumor of bone
    V H Rao
    Meyer Rehabilitation Institute and Department of Pediatrics, University of Nebraska Medical Center, Omaha 68198, USA
    Clin Exp Metastasis 15:400-9. 1997
    ..This suggests that multinucleated giant cells in primary cultures secrete a factor(s) that stimulates stromal cells to produce MMP-9, which, in turn, may contribute to the aggressive behavior of GCT...
  55. ncbi Expression of bone morphogenetic proteins in giant cell tumor of bone
    Naoko Kudo
    Division of Orthopedic Surgery, Department of Regenerative Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Niigata 951 8510, Japan
    Anticancer Res 29:2219-25. 2009
    ..Although the bone formation in GCT in supposedly due to bone morphogenetic proteins (BMPs), the expression pattern of BMPs in GCT has not been well investigated...
  56. ncbi Argon beam coagulation as an adjuvant for local control of giant cell tumor
    Valerae O Lewis
    MD Anderson Cancer Center, Houston, TX, USA
    Clin Orthop Relat Res 454:192-7. 2007
    ..These data suggest argon beam coagulation as an adjuvant therapy is associated with in a low rate of local recurrence and is a reasonable adjuvant treatment option...
  57. ncbi Does the addition of cement improve the rate of local recurrence after curettage of giant cell tumours in bone?
    C L Gaston
    Royal Orthopaedic Hospital NHS Foundation Trust, Bristol Road South, Northfield, Birmingham B31 2AP, UK
    J Bone Joint Surg Br 93:1665-9. 2011
    ..001). In patients who developed local recurrence, 75.0% (9 of 12) of those with previous cementation required a joint replacement, compared with 45.2% (33 of 73) of those without cement (p = 0.044)...
  58. ncbi Histological and clinical characteristics of malignant giant cell tumor of bone
    Lihua Gong
    Department of Pathology, Beijing Jishuitan Hospital, Fourth Medical College of Peking University, Teaching Hospital of Tsinghua University, 31 Xinjiekou East Street, Xicheng District, Beijing 100035, China
    Virchows Arch 460:327-34. 2012
    ..Five cases were primary malignant giant cell tumor of bone (PMGCTB), and 12 cases were giant cell tumors of bone initially diagnosed as benign but malignant in a ..
  59. ncbi PTHrP increases RANKL expression by stromal cells from giant cell tumor of bone
    Robert W Cowan
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Orthop Res 30:877-84. 2012
    b>Giant cell tumor of bone (GCT) presents with numerous osteoclast-like multinucleated giant cells that are principally responsible for the extensive bone resorption by the tumor...
  60. ncbi Metastasis of giant cell tumor to the breast: case report and review of the literature
    Ahmet Alacacioglu
    Institute of Oncology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey
    Tumori 92:351-3. 2006
    ....
  61. ncbi [Giant cell tumor at the wrist: a review of 23 cases]
    Tackin Ozalp
    Celal Bayar Universitesi Tip Fakültesi Ortopedi ve Travmatoloji Anabilim Dali
    Acta Orthop Traumatol Turc 40:144-50. 2006
    ....
  62. pmc Ethanol as a local adjuvant for giant cell tumor of bone
    Kevin B Jones
    Department of Orthopaedics and Rehabilitation, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 01051 John Pappajohn Pavilion, Iowa City, IA 52242, USA
    Iowa Orthop J 26:69-76. 2006
    ..Until such evidence becomes available, the use of adjuvant ethanol offers a compromise between higher toxicity adjuvants and no chemical adjuvant at all...
  63. pmc Giant cell tumour of bone: morphological, biological and histogenetical aspects
    Mathias Werner
    Institute of Osteopathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Int Orthop 30:484-9. 2006
    ..Further research of the pathogenesis of GCT as well as the complex interactions of its cellular populations may provide the knowledge necessary for developing approaches for a biological-based therapy of this neoplasm...
  64. ncbi Bisphosphonates induce apoptosis of stromal tumor cells in giant cell tumor of bone
    Y Y Cheng
    Department of Orthopaedics and Traumatology, Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR
    Calcif Tissue Int 75:71-7. 2004
    ..41% at 150 microM, followed by pamidronate (22.23%) and alendronate (15.3%). Our observations suggest that these drugs may be considered as potential adjuvants in the treatment of GCT...
  65. ncbi Hip joint remodeling in an adult following excision of a giant cell tumor involving the acetabulum: a case report and literature review
    Hideji Nishida
    Department of Orthopedic Surgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    Arch Orthop Trauma Surg 126:458-63. 2006
    We describe a 47-year-old man with a giant cell tumor of bone involving the acetabulum treated with curettage and bone grafting which resulted in good remodeling of the hip joint...
  66. ncbi [Clinicopathologic study of giant cell angioblastoma]
    Rong Jun Mao
    Department of Pathology, Foshan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Foshan 528000, China
    Zhonghua Bing Li Xue Za Zhi 39:752-6. 2010
    ..to study the clinicopathological features, imaging characteristics, immunophenotypes and differential diagnosis of giant cell angioblastoma (GCAB)...
  67. ncbi Giant cell tumor of bone with pulmonary metastases
    Yasuhiro Okamoto
    Med Pediatr Oncol 41:454-9. 2003
  68. ncbi Pamidronate, farnesyl transferase, and geranylgeranyl transferase-I inhibitors affects cell proliferation, apoptosis, and OPG/RANKL mRNA expression in stromal cells of giant cell tumor of bone
    Carol P Y Lau
    Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Room 74034 5 F, Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong
    J Orthop Res 29:403-13. 2011
    ..Our findings support that the combination of bisphosphonates with GGTIs or FTIs with GGTIs may be used as potential adjuvants in the treatment of GCT of bone...
  69. pmc Soft tissue extension increases the risk of local recurrence after curettage with adjuvants for giant-cell tumor of the long bones
    L van der Heijden
    Department of Orthopaedic Surgery, Leiden University Medical Center, The Netherlands
    Acta Orthop 83:401-5. 2012
    ..The aim of the study was the identification of individual risk factors after curettage with adjuvants in GCTB...
  70. ncbi Differentially expressed genes in giant cell tumor of bone
    Erica Babeto
    Laboratory of Genomics Studies, Sao Paulo State University UNESP, Cristóvão Colombo, 2265, 15054 000, Sao Jose do Rio Preto, SP, Brazil
    Virchows Arch 458:467-76. 2011
    ....
  71. ncbi Giant Cell Tumor (tumor gigantocellularis, osteoclastoma) - epidemiology, diagnosis, treatment
    Marta Karpik
    Department of Clinical Orthopaedics and Traumatology, Medical University Hospital in Białystok
    Ortop Traumatol Rehabil 12:207-15. 2010
    ..b>Giant Cell Tumor of Bone accounts for 4-8% of primary bone tumors. It is most commonly seen in women aged 20 to 40 years...
  72. ncbi The role of TWIST as a regulator in giant cell tumor of bone
    Shalini Singh
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    J Cell Biochem 112:2287-95. 2011
    b>Giant cell tumor of bone (GCT) is an aggressive tumor consisting of multinucleated osteoclast-like giant cells and proliferating osteoblast-like stromal cells...
  73. ncbi Interferon alfa-2b for recurrent and metastatic giant cell tumor of the spine: report of two cases
    Feng Wei
    Department of Orthopedics, Peking University Third Hospital, Beijing, China
    Spine (Phila Pa 1976) 35:E1418-22. 2010
    ..Case report...
  74. ncbi Recruitment of osteoclast precursors by stromal cell derived factor-1 (SDF-1) in giant cell tumor of bone
    Ted S Liao
    Center for Orthopaedic Research, Department of Orthopaedic Surgery, Columbia University, 622 W 168th Street, BHN816, New York, NY 10032, USA
    J Orthop Res 23:203-9. 2005
    ..These results suggest that SDF-1 is one of the significant chemoattractant factors involved in the recruitment of hematopoietic osteoclast precursor cells during tumor-induced osteoclastogenesis...
  75. ncbi Giant cell tumor of the sternum: a case report and review of the literature
    Hiroyuki Futani
    Department of Orthopaedic Surgery, Hyogo College of Medicine, 1 1 Mukogawa Nishinomiya, Hyogo 663 8501, Japan
    Anticancer Res 28:4117-20. 2008
    ..The initial treatment should be extended curettage followed by filling with PMMA...
  76. ncbi Bisphosphonates reduce local recurrence in extremity giant cell tumor of bone: a case-control study
    Lung Fung Tse
    Department of Orthopaedics and Traumatology, Prince of Wales Hospital, Shatin, Hong Kong
    Bone 42:68-73. 2008
    ..Therefore our clinical study aims to investigate whether the administration of bisphosphonate as an adjuvant can further decrease local recurrence following the surgical treatment of GCT of bone...
  77. pmc Bisphosphonate treatment of aggressive primary, recurrent and metastatic Giant Cell Tumour of Bone
    Maurice Balke
    Department of Orthopaedic Surgery, University of Munster, Munster, Germany
    BMC Cancer 10:462. 2010
    ..GCTB frequently recurs and can produce metastatic lesions in the lungs. Bisphosphonates are anti-resorptive drugs which act mainly on osteoclasts...
  78. ncbi Giant cell tumor of bone
    William M Mendenhall
    Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA
    Am J Clin Oncol 29:96-9. 2006
    ..To discuss the treatment and outcomes for giant cell tumor (GCT) of bone...
  79. pmc Giant cell tumor of bone: risk factors for recurrence
    Frank M Klenke
    Department of Orthopedic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Clin Orthop Relat Res 469:591-9. 2011
    Many surgeons treat giant cell tumor of bone (GCT) with intralesional curettage. Wide resection is reserved for extensive bone destruction where joint preservation is impossible or when expendable sites (eg, fibular head) are affected...
  80. pmc Giant-cell tumors of bone: an analysis of 87 cases
    Yu Ping Su
    Department of Orthopaedics and Traumatology, Veterans General Hospital, 201, Sec 2, Shih Pai Road, 112, Taipei, Taiwan, ROC
    Int Orthop 28:239-43. 2004
    ..Functional outcome was evaluated using the Enneking scoring system. Average rating was 86% for the lower extremity and 83% for the upper extremity. The overall satisfactory rate was 88%...
  81. pmc Molecular profiling of giant cell tumor of bone and the osteoclastic localization of ligand for receptor activator of nuclear factor kappaB
    Teresa Morgan
    Ian Potter Foundation Center for Cancer Genomics and Predictive Medicine and Research Division, Peter MacCallum Cancer Center, Melbourne, Australia
    Am J Pathol 167:117-28. 2005
    b>Giant cell tumor of bone (GCT) is a generally benign, osteolytic neoplasm comprising stromal cells and osteoclast-like giant cells...
  82. ncbi Antiangiogenic therapy with interferon alpha for giant cell lesions of the jaws
    Leonard B Kaban
    Walter C Guralnick Professor and Chairman, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital and Harvard School of Dental Medicine, Boston 02114, USA
    J Oral Maxillofac Surg 60:1103-11; discussion 1111-3. 2002
    ..The purpose of this report is to present a treatment protocol consisting of enucleation, with preservation of vital structures, followed by subcutaneous interferon alpha...
  83. ncbi Gene expression profiling identifies p63 as a diagnostic marker for giant cell tumor of the bone
    Cheng Han Lee
    Department of Pathology, Stanford University, Stanford, CA, USA
    Mod Pathol 21:531-9. 2008
    ..These findings altogether show that p63 can be used as a diagnostic marker to aid the clinical diagnosis of GCTOB...
  84. ncbi What's new in musculoskeletal oncology
    Valerae O Lewis
    MD Anderson Cancer Center, P O Box 301402, Unit 408, Houston, TX 77230 1402, USA
    J Bone Joint Surg Am 89:1399-407. 2007
  85. ncbi From the archives of AFIP. Imaging of giant cell tumor and giant cell reparative granuloma of bone: radiologic-pathologic correlation
    M D Murphey
    Department of Radiologic Pathology, Armed Forces Institute of Pathology, 6825 16th St NW, Bldg 54, Rm M 133A, Washington, DC 20306, USA
    Radiographics 21:1283-309. 2001
    ..Recognition of the spectrum of radiologic appearances of GCT and GCRG is important in allowing prospective diagnosis, guiding therapy, and facilitating early detection of recurrence...
  86. ncbi Joint salvage for pathologic fracture of giant cell tumor of the lower extremity
    Benjamin M Deheshi
    University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Ontario, Canada
    Clin Orthop Relat Res 459:96-104. 2007
    ..Joint salvage for patients with pathologic fractures through giant cell tumor of weightbearing bones is a reasonable option with functional outcomes and recurrence rates comparable to those of patients without fracture...
  87. pmc Reconstruction of the distal radius by fibula following excision of giant cell tumor
    V K Aithal
    Department of Orthopedics, Nizwa Hospital, P O Box 1222, Sultanate of Oman
    Int Orthop 27:110-3. 2003
    ..2 months. The surgical technique using a radiofibular plate and K wire through the wrist had a low nonunion rate, no graft related complications, good range of movement, and good hand functions...
  88. ncbi Giant-cell tumour of bone
    M Szendroi
    Department of Orthopaedics, Semmelweis University, Budapest, Hungary
    J Bone Joint Surg Br 86:5-12. 2004
  89. ncbi Multicentric giant cell tumor of bone. Clinicopathologic analysis of thirty cases
    Benjamin Hoch
    Mayo Clinic, Rochester, MN 55905, USA
    J Bone Joint Surg Am 88:1998-2008. 2006
    b>Giant cell tumor of bone accounts for 4% to 5% of primary bone tumors. Approximately 1% of cases present as multiple synchronous or metachronous lesions...
  90. ncbi [Giant cell tumor of bone. An evaluation of 87 patients]
    P U Tunn
    Klinik fur Chirurgie und Chirurgische Onkologie, Charite Universitatsmedizin Berlin
    Z Orthop Ihre Grenzgeb 141:690-8. 2003
    ..Giant cell tumor (GCT) of bone is a very peculiar and interesting tumor due to of its biological behavior and the phenomenon of pulmonary metastases of a histologically benign tumor. We present the results of a retrospective study...
  91. ncbi Megavoltage radiation therapy for axial and inoperable giant-cell tumor of bone
    A Chakravarti
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    J Bone Joint Surg Am 81:1566-73. 1999
    ..We performed the present study to evaluate the efficacy of megavoltage radiation in terms of lack of tumor progression and treatment-related morbidity...
  92. pmc Local control of long bone giant cell tumour using curettage, burring and bone grafting without adjuvant therapy
    F Malek
    San Francisco Department of Orthopaedic Surgery UCSF Comprehensive Cancer Center Orthopaedic Oncology Service, University of California, San Francisco, CA 94115 1939, USA
    Int Orthop 30:495-8. 2006
    ..In cases where more resources are available, the addition of adjuvant therapies, as noted in the recent literature, may be beneficial. The results of this study should be considered when designing multicenteric studies in the future...
  93. ncbi Cytochemical and ultrastructural changes in the osteoclast-like giant cells of giant cell tumor of bone following bisphosphonate administration
    Yuen Y Cheng
    Department of Orthopaedics and Traumatology, Chinese University of Hong Kong, Hong Kong, China
    Ultrastruct Pathol 27:385-91. 2003
    b>Giant cell tumor of bone (GCT) is a local aggressive neoplasm of bone characterized by expansive osteolytic lesions at the epiphysis of long bones...
  94. ncbi Radiotherapy in the management of giant cell tumor of bone
    Jimmy J Caudell
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 57:158-65. 2003
    To evaluate the outcomes of patients with giant cell tumor of bone (GCTB) treated with radiotherapy (RT) with or without surgical resection.
  95. ncbi Multicentric giant cell tumor of bone: ten lesions at presentation
    Il Hyung Park
    Department of Orthopaedic Surgery, Kyungpook National University Hospital, 50 Samduk, Chung gu, 700 721 Taegu, Korea South
    Skeletal Radiol 32:526-9. 2003
    The case of a 19-year-old man with multicentric and subsequent metachronous giant cell tumor of bone is presented. Ten lesions were identified at presentation and eventually two more lesions developed...
  96. ncbi Expression of VEGF and MMP-9 in giant cell tumor of bone and other osteolytic lesions
    S M Kumta
    Department of Orthopaedics and Traumatology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N T Hongkong, China
    Life Sci 73:1427-36. 2003
    ..the expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in giant cell tumor of bone (GCT) and other osteolytic lesions in bone...
  97. ncbi Giant cell tumor of bone: an immunohistochemical comparative study
    F Masui
    Department of Pathology, Jikei University School of Medicine, Tokyo, Japan
    Pathol Int 48:355-61. 1998
    ....
  98. ncbi Giant cell tumor of bone: a clinicopathologic study of prognostic factors
    F Masui
    Department of Pathology, Jikei University School of Medicine, Tokyo, Japan
    Pathol Int 48:723-9. 1998
    Forty-seven cases of giant cell tumor of bone were clinicopathologically reviewed to determine any useful prognostic factors. Disease recurred in 11 cases...
  99. ncbi Malignancy in giant cell tumor of bone
    Franco Bertoni
    Istituto Ortopedico Rizzoli, Bologna, Italy
    Cancer 97:2520-9. 2003
    ..The goals of the current study were to define the clinicopathologic and histologic features of malignancy in giant cell tumors and to clarify the terminology...
  100. ncbi Cement is recommended in intralesional surgery of giant cell tumors: a Scandinavian Sarcoma Group study of 294 patients followed for a median time of 5 years
    Aarne H Kivioja
    Department of Orthopedics and Traumatology, Helsinki University Central Hospital, Helsinki, Finland
    Acta Orthop 79:86-93. 2008
    ..Giant cell tumors of bone rarely metastasize but often recur locally after surgery. There is limited knowledge about the risk of recurrence related to different types of treatment...
  101. ncbi Complications associated with bone cementing for the treatment of giant cell tumors of bone
    Takuro Wada
    Department of Orthopaedic Surgery, Sapporo Medical University, South 1, West 16, Sapporo 060 8543, Japan
    J Orthop Sci 7:194-8. 2002
    ..Acrylic cement reconstruction is a safe and effective procedure that provides local adjuvant therapy. Giant cell tumors with an associated intraarticular fracture remain a challenging problem to treat...

Research Grants7

  1. RANK-Associated Inhibitor (RAIN) in Osteoclast Formation
    Bryant Darnay; Fiscal Year: 2007
    ..and have been implicated in various diseases, which include rheumatoid arthritis, osteoporosis, giant cell tumor of bone, Paget's disease, metastatic breast cancer, multiple myeloma, and familial expansile osteolysis...
  2. ANALYSIS OF HYPERTHERMIA OF GIANT CELL TUMORS OF BONE
    David Nelson; Fiscal Year: 1991
    ..This will simulate the thermal effects of acrylic cementation following curettage of a giant cell tumor of bone. The procedure has been shown to result in a lower rate of tumor recurrence than is seen with curettage ..
  3. METABOLISM IN NORMAL AND OSTEOARTHRITIC CARTILAGE
    Henry Mankin; Fiscal Year: 2001
    ..It is further speculated that the study of serine proteinases produced by OA cartilage may have strong implications for the management of this debilitating disease. ..
  4. INVESTIGATING THE MECHANISMS OF PRB TUMOR SUPPRESSION
    Arnab Chakravarti; Fiscal Year: 2003
    ..Specific Aim number 3: To determine whether the deregulation of E2F dependent transcription is correlated with the tumorigenic potential of RB -/- cells in-vivo. ..
  5. Minimally Invasive Approaches for Craniofacial Surgery
    Maria Troulis; Fiscal Year: 2005
    ..abstract_text> ..
  6. Molecular Mechanisms of Ectopic Bone Formation
    STEVEN LIETMAN; Fiscal Year: 2006
    ..abstract_text> ..
  7. Bioengineering Annulus Fibrosus using Silk Scaffold
    Rita Kandel; Fiscal Year: 2006
    ..The viability and mechanical properties of the tissue will be evaluated. ..