Genomes and Genes
giant cell tumor of bone
Summary: A bone tumor composed of cellular spindle-cell stroma containing scattered multinucleated giant cells resembling osteoclasts. The tumors range from benign to frankly malignant lesions. The tumor occurs most frequently in an end of a long tubular bone in young adults. (From Dorland, 27th ed; Stedman, 25th ed)
Publications186 found, 100 shown here
- [Giant cell tumor of bone with rapid malignant course]M R Lachat
, Stadtspital Triemli, , Switzerland
Orthopade 33:344-8. 2004..Following the diagnosis of giant cell tumor of bone (GCT) on biopsy and curettage, a rapid malignant course was observed with recurrence 2.5 months later...
- Are fibula strut allografts a reliable alternative for periarticular reconstruction after curettage for bone tumors?Peter J Buecker
Harvard Medical School, Beth Israel Deaconess Medical Center, Children s Hospital Boston, Boston, MA, USA
Clin Orthop Relat Res 461:170-4. 2007....
- Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of boneIsabella W Y Mak
McMaster University, Hamilton, Ontario, Canada L8V 5C2
Hum Pathol 41:1320-9. 2010b>Giant cell tumor of bone (GCT) is an aggressively osteolytic primary bone tumor that is characterized by the presence of abundant multinucleated osteoclast-like giant cells, hematopoietic monocytes, and a distinct mesenchymal stromal cell ..
- Upregulation of MMP-13 via Runx2 in the stromal cell of Giant Cell Tumor of boneIsabella W Y Mak
Department of Surgery, McMaster University, Hamilton, Ontario, Canada
Bone 45:377-86. 2009b>Giant Cell Tumor of bone (GCT) is an aggressively osteolytic and cytokine-rich bone tumor...
- Cathepsin K is the principal protease in giant cell tumor of boneJan H N Lindeman
Department of Biomedical Research, TNO Prevention and Health, PO Box 2215, 2301 CE Leiden, The Netherlands
Am J Pathol 165:593-600. 2004..Inhibition of cathepsin K or its associated proton-pump may provide new therapeutic opportunities for GCT...
- Properties of the stromal cell in giant cell tumor of boneMichelle Ghert
McMaster University, Hamilton Health Sciences and the Juravinski Cancer Centre, Hamilton, Ontario, Canada
Clin Orthop Relat Res 459:8-13. 2007..The spindle like stromal cells of GCT have characteristics of osteoblast progenitors and produce active matrix-degrading proteases. These cells may therefore play a central role in bone destruction...
- Local recurrence of giant cell tumor of bone after intralesional treatment with and without adjuvant therapyWolfgang T Becker
Orthopädische Klinik Volmarstein, Universitat Witten Herdecke, Wetter, Germany
J Bone Joint Surg Am 90:1060-7. 2008The use of adjuvants after curettage has been well established for the treatment of giant cell tumor of bone. The purpose of this study was to analyze the rates of recurrence following different types of treatment as well as the influence ..
- Treatment options for recurrent giant cell tumors of boneMaurice Balke
Department of Orthopedic Surgery, University of Muenster, Albert Schweitzer Str 33, 48149, Munster, Germany
J Cancer Res Clin Oncol 135:149-58. 2009..The possible surgical procedures range from repeated intralesional curettage to wide resection...
- Bisphosphonate treatment of aggressive primary, recurrent and metastatic Giant Cell Tumour of BoneMaurice Balke
Department of Orthopaedic Surgery, University of Munster, Munster, Germany
BMC Cancer 10:462. 2010..GCTB frequently recurs and can produce metastatic lesions in the lungs. Bisphosphonates are anti-resorptive drugs which act mainly on osteoclasts...
- Morphological and immunophenotypic features of primary and metastatic giant cell tumour of boneM Alberghini
Istituto Ortopedico Rizzoli, Bologna, Italy
Virchows Arch 456:97-103. 2010..Our findings suggest that most lung nodules associated with primary conventional GCTBs are implants derived from tumour emboli formed in areas of haemorrhage and thrombus formation within the primary tumour...
- Bisphosphonates reduce local recurrence in extremity giant cell tumor of bone: a case-control studyLung Fung Tse
Department of Orthopaedics and Traumatology, Prince of Wales Hospital, Shatin, Hong Kong
Bone 42:68-73. 2008..Therefore our clinical study aims to investigate whether the administration of bisphosphonate as an adjuvant can further decrease local recurrence following the surgical treatment of GCT of bone...
- Giant cell tumor of bone: treatment and outcome of 214 casesMaurice Balke
Department of Orthopedic Surgery, University of Muenster, Muenster, Germany
J Cancer Res Clin Oncol 134:969-78. 2008Two hundred and fourteen patients with benign giant cell tumor of bone (GCTB), treated from 1980 to 2007 at the Department of Orthopedics of the University of Muenster (Germany), were analyzed in a retrospective study.
- Multicentric giant cell tumor of bone: ten lesions at presentationIl-Hyung Park
Department of Orthopaedic Surgery, Kyungpook National University Hospital, 50 Samduk, Chung-gu, 700-721 Taegu, Korea (South
Skeletal Radiol 32:526-9. 2003The case of a 19-year-old man with multicentric and subsequent metachronous giant cell tumor of bone is presented. Ten lesions were identified at presentation and eventually two more lesions developed...
- [Giant cell tumor of bone and malignancies in giant cell tumor: a clinicopathologic analysis]Li hua Gong
Department of Pathology, Beijing Jishuitan Hospital, Beijing 100035, China
Zhonghua Bing Li Xue Za Zhi 38:312-5. 2009..To study the clinicopathologic features, diagnosis and differential diagnosis of malignancies in giant cell tumor (MGCT)...
- Malignancy in giant cell tumor of boneFranco Bertoni
Istituto Ortopedico Rizzoli, Bologna, Italy
Cancer 97:2520-9. 2003..The goals of the current study were to define the clinicopathologic and histologic features of malignancy in giant cell tumors and to clarify the terminology...
- Aneurysmal bone cyst and giant cell tumor of bone of the hand and distal radiusEdward A Athanasian
Hospital for Special Surgery, 535 East 70th Street, New York, New York 10021, USA
Hand Clin 20:269-81, vi. 2004Aneurysmal bone cyst and giant cell tumor of bone have historically been considered benign lesions that can behave in locally aggressive fashion. The clinical and pathologic findings share some common characteristics...
- Impact severity of local recurrence in giant cell tumor of boneRichard L McGough
From the University of Texas M.D. Anderson Cancer Center, Department of Orthopaedic Oncology, Houston, TX
Clin Orthop Relat Res 438:116-22. 2005..Despite its benign histology, giant cell tumor of bone is an aggressive tumor that demands meticulous attention to surgical detail and close postoperative ..
- Thapsigargin potentiates TRAIL-induced apoptosis in giant cell tumor of boneLin Huang
Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, N.T, Hongkong SAR, China
Bone 34:971-81. 2004..In this study, we examined the potentiation of TRAIL-induced apoptosis in the stromal-like tumor cells of giant cell tumor of bone (GCT)...
- Giant-cell tumour of bone. The long-term results of treatment by curettage and bone graftW Zhen
Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xian City, Shannxi, China
J Bone Joint Surg Br 86:212-6. 2004..Three had moderate function, and three needed amputation. Our findings indicate that treatment with an aqueous solution of zinc chloride and reconstructive bone grafting after curettage gives good results...
- [Giant cell tumor of bone. An evaluation of 87 patients]P U Tunn
Klinik fur Chirurgie und Chirurgische Onkologie, Charite Universitatsmedizin Berlin
Z Orthop Ihre Grenzgeb 141:690-8. 2003..Giant cell tumor (GCT) of bone is a very peculiar and interesting tumor due to of its biological behavior and the phenomenon of pulmonary metastases of a histologically benign tumor. We present the results of a retrospective study...
- Metastatic giant cell tumor of bone: are there associated factors and best treatment modalities?Seethalakshmi Viswanathan
Department of Pathology, Tata Memorial Hospital, Parel, Mumbai 400012, India
Clin Orthop Relat Res 468:827-33. 2010..None of the patients died of their metastatic disease. None of the risk factors we studied was associated with metastasis in giant cell tumors. Although the overall outcome was favorable, metastasectomy is recommended where feasible...
- Expression of VEGF and MMP-9 in giant cell tumor of bone and other osteolytic lesionsS M Kumta
Department of Orthopaedics and Traumatology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N T Hongkong, China
Life Sci 73:1427-36. 2003..the expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in giant cell tumor of bone (GCT) and other osteolytic lesions in bone...
- Radiotherapy in the management of giant cell tumor of boneJimmy J Caudell
Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 57:158-65. 2003PURPOSE: To evaluate the outcomes of patients with giant cell tumor of bone (GCTB) treated with radiotherapy (RT) with or without surgical resection...
- Giant cell tumor of bone express p63Brendan C Dickson
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada
Mod Pathol 21:369-75. 2008..The purpose of this study was to investigate p63 expression in giant cell tumor of bone and to determine whether it can be used to discriminate between other giant cell-rich tumors...
- Giant cell tumour of boneDavid M Thomas
Departments of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Curr Opin Oncol 21:338-44. 2009..Giant cell tumour of bone (GCT) is the most common benign bone tumour and afflicts a young population. Treatment options for patients with unresectable disease have remained fairly static for the past three decades...
- Cement is recommended in intralesional surgery of giant cell tumors: a Scandinavian Sarcoma Group study of 294 patients followed for a median time of 5 yearsAarne H Kivioja
Department of Orthopedics and Traumatology, Helsinki University Central Hospital, Helsinki, Finland
Acta Orthop 79:86-93. 2008..Giant cell tumors of bone rarely metastasize but often recur locally after surgery. There is limited knowledge about the risk of recurrence related to different types of treatment...
- Histogenetic characterization of giant cell tumor of boneManuela Salerno
Laboratory for Pathophysiology, Istituto Ortopedico Rizzoli, 40136 Bologna, Italy
Clin Orthop Relat Res 466:2081-91. 2008..The increased number of giant cells in GCT may be secondary to an autocrine circuit mediated by the receptor activator of nuclear factor kB...
- Effectiveness of intravenous bisphosphonate in treatment of giant cell tumor: a case report and review of the literatureOlarn Arpornchayanon
Department of Orthopedics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
J Med Assoc Thai 91:1609-12. 2008..The patient's gait was normal. From the present study, the authors demonstrate the effectiveness of zoledronate for treatment of giant cell tumor at the sacrum. It can reduce the morbidity from major surgery...
- Giant cell tumour of bone: morphological, biological and histogenetical aspectsMathias Werner
Institute of Osteopathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Int Orthop 30:484-9. 2006..Further research of the pathogenesis of GCT as well as the complex interactions of its cellular populations may provide the knowledge necessary for developing approaches for a biological-based therapy of this neoplasm...
- Multicentric giant cell tumor of bone. Clinicopathologic analysis of thirty casesBenjamin Hoch
Mayo Clinic, Rochester, MN 55905, USA
J Bone Joint Surg Am 88:1998-2008. 2006b>Giant cell tumor of bone accounts for 4% to 5% of primary bone tumors. Approximately 1% of cases present as multiple synchronous or metachronous lesions...
- Histologically verified lung metastases in benign giant cell tumours--14 cases from a single institutionM Dominkus
University Clinic of Vienna, Department of Orthopaedics, Allgemeines Krankenhaus der Stadt Wien, Vienna, Austria
Int Orthop 30:499-504. 2006..We conclude that even metastatic benign giant cell tumours have an excellent prognosis after adequate resection. No prognostic factors despite high-grade lesions were detectable...
- Local control of long bone giant cell tumour using curettage, burring and bone grafting without adjuvant therapyF Malek
San Francisco Department of Orthopaedic Surgery UCSF Comprehensive Cancer Center Orthopaedic Oncology Service, University of California, San Francisco, CA 94115 1939, USA
Int Orthop 30:495-8. 2006..In cases where more resources are available, the addition of adjuvant therapies, as noted in the recent literature, may be beneficial. The results of this study should be considered when designing multicenteric studies in the future...
- Treatment of local recurrences of giant cell tumour in long bones after curettage and cementing. A Scandinavian Sarcoma Group studyF Vult von Steyern
Department of Orthopaedics, Lund University Hospital, SE 221 85 Lund, Sweden
J Bone Joint Surg Br 88:531-5. 2006....
- Genomic instability in giant cell tumor of bone. A study of 52 cases using DNA ploidy, relocalization FISH, and array-CGH analysisLinda Moskovszky
1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Ulloi ut 26, Budapest 1085, Hungary
Genes Chromosomes Cancer 48:468-79. 2009Genetic instability in relation to clinical behavior was studied in 52 cases of giant cell tumor of bone (GCTB). Ploidy was determined in the mononuclear cell population by using native cell smears and image cytometry...
- Giant cell tumor of boneWilliam M Mendenhall
Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA
Am J Clin Oncol 29:96-9. 2006..To discuss the treatment and outcomes for giant cell tumor (GCT) of bone...
- Giant cell tumor of boneRobert E Turcotte
Division of Orthopaedic Surgery, McGill University, Montreal, Quebec, Canada
Orthop Clin North Am 37:35-51. 2006..Preferred treatment usually consists of extensive curettage and filling of the cavity with bone graft or cement. Debate still exists about the usefulness of local adjuvant treatment. Functional outcome is usually very good...
- Phenotypic and molecular studies of giant-cell tumors of bone and soft tissueYu Sin Lau
Department of Pathology, University of Oxford, Nuffield Orthopaedic Centre, OX3 7LD Oxford, UK
Hum Pathol 36:945-54. 2005..Inhibitors of osteoclast formation and activity are likely to be effective in controlling the osteolysis associated with GCTB and possibly other giant-cell-rich lesions...
- Cytogenetic analysis of 101 giant cell tumors of bone: nonrandom patterns of telomeric associations and other structural aberrationsLudmila Gorunova
Department of Medical Genetics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
Genes Chromosomes Cancer 48:583-602. 2009b>Giant cell tumor of bone (GCTB) is a benign but locally aggressive tumor with metastatic potential. We performed cytogenetic analysis on 101 GCTB from 92 patients...
- Molecular profiling of giant cell tumor of bone and the osteoclastic localization of ligand for receptor activator of nuclear factor kappaBTeresa Morgan
Ian Potter Foundation Center for Cancer Genomics and Predictive Medicine and Research Division, Peter MacCallum Cancer Center, Melbourne, Australia
Am J Pathol 167:117-28. 2005b>Giant cell tumor of bone (GCT) is a generally benign, osteolytic neoplasm comprising stromal cells and osteoclast-like giant cells...
- Primary malignant giant-cell tumor of bone has high survival rateStepan V Domovitov
Orthopaedic Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, USA
Ann Surg Oncol 17:694-701. 2010..This study compared malignant to benign GCTs and defined the clinical outcome of the patients in a large series of case-matched patients from a single institution...
- Cytochemical and ultrastructural changes in the osteoclast-like giant cells of giant cell tumor of bone following bisphosphonate administrationYuen-Y Cheng
Department of Orthopaedics and Traumatology, Chinese University of Hong Kong, Hong Kong, China
Ultrastruct Pathol 27:385-91. 2003b>Giant cell tumor of bone (GCT) is a local aggressive neoplasm of bone characterized by expansive osteolytic lesions at the epiphysis of long bones...
- Complications associated with bone cementing for the treatment of giant cell tumors of boneTakuro Wada
Department of Orthopaedic Surgery, Sapporo Medical University, South-1, West-16, Sapporo 060-8543, Japan
J Orthop Sci 7:194-8. 2002..Acrylic cement reconstruction is a safe and effective procedure that provides local adjuvant therapy. Giant cell tumors with an associated intraarticular fracture remain a challenging problem to treat...
- De novo malignant transformation of giant cell tumor of boneT Marui
Department of Orthopaedic Surgery, Kobe University School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
Skeletal Radiol 30:104-8. 2001..In both patients, radiation and never been given. Malignant transformation has rarely been reported in patients with GCT of bone who have not received radiation treatment...
- Giant cell tumor of bone: a clinicopathologic study of prognostic factorsF Masui
Department of Pathology, Jikei University School of Medicine, Tokyo, Japan
Pathol Int 48:723-9. 1998Forty-seven cases of giant cell tumor of bone were clinicopathologically reviewed to determine any useful prognostic factors. Disease recurred in 11 cases...
- Megavoltage radiation therapy for axial and inoperable giant-cell tumor of boneA Chakravarti
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
J Bone Joint Surg Am 81:1566-73. 1999..We performed the present study to evaluate the efficacy of megavoltage radiation in terms of lack of tumor progression and treatment-related morbidity...
- Long-term follow-up of patients with giant cell tumor of the sacrum treated with selective arterial embolizationPatrick P Lin
Section of Orthopaedic Oncology, M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 95:1317-25. 2002..The goal of this study is to evaluate the long-term outcome of selective arterial embolization as an alternative treatment modality...
- Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 studyDavid Thomas
Peter MacCallum Cancer Centre, East Melbourne, Vic, Australia
Lancet Oncol 11:275-80. 2010..We investigated the potential therapeutic effect of denosumab, a fully human monoclonal antibody against RANKL, on tumour-cell survival and growth in patients with GCT...
- Giant cell tumor of bone: an immunohistochemical comparative studyF Masui
Department of Pathology, Jikei University School of Medicine, Tokyo, Japan
Pathol Int 48:355-61. 1998....
- Cytogenetic-morphologic correlations in aneurysmal bone cyst, giant cell tumor of bone and combined lesions. A report from the CHAMP study groupR Sciot
Department of Pathology, University of Leuven, Belgium
Mod Pathol 13:1206-10. 2000Aneurysmal bone cyst and giant cell tumor of bone are relatively rare bone tumors that sometimes coexist. We examined the karyotypes of 3 aneurysmal bone cysts, 12 giant cell tumors, and 3 combined lesions...
- Osteoclast-type giant cell neoplasm of salivary gland. A microdissection-based comparative genotyping assay and literature review: extraskeletal "giant cell tumor of bone" or osteoclast-type giant cell "carcinoma"?Loretta L Y Tse
Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong, China
Am J Surg Pathol 28:953-61. 2004Primary salivary gland tumors resembling giant cell tumor of bone are very rare and have unsettled histogenesis. Both mesenchymal and epithelial origins have been suggested...
- Giant-cell tumors of bone: an analysis of 87 casesYu-Ping Su
Department of Orthopaedics and Traumatology, Veterans General Hospital, 201, Sec. 2, Shih-Pai Road, 112, Taipei, Taiwan, ROC
Int Orthop 28:239-43. 2004..Functional outcome was evaluated using the Enneking scoring system. Average rating was 86% for the lower extremity and 83% for the upper extremity. The overall satisfactory rate was 88%...
- Recurrent giant cell tumor of bone with simultaneous regional lymph node and pulmonary metastasesSajid S Qureshi
Department of Bone and Soft Tissue, Tata Memorial Hospital, E. Borges Road, Parel, Bombay, India
Skeletal Radiol 34:225-8. 2005..In this case report we document a case of giant cell tumor of the patella in which, associated with local recurrence, there were simultaneous metastases to lymph nodes and lungs...
- Ethanol as a local adjuvant for giant cell tumor of boneKevin B Jones
Department of Orthopaedics and Rehabilitation, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 01051 John Pappajohn Pavilion, Iowa City, IA 52242, USA
Iowa Orthop J 26:69-76. 2006..Until such evidence becomes available, the use of adjuvant ethanol offers a compromise between higher toxicity adjuvants and no chemical adjuvant at all...
- Recruitment of osteoclast precursors by stromal cell derived factor-1 (SDF-1) in giant cell tumor of boneTed S Liao
Center for Orthopaedic Research, Department of Orthopaedic Surgery, Columbia University, 622 W. 168th Street, BHN816, New York, NY 10032, USA
J Orthop Res 23:203-9. 2005..These results suggest that SDF-1 is one of the significant chemoattractant factors involved in the recruitment of hematopoietic osteoclast precursor cells during tumor-induced osteoclastogenesis...
- Bisphosphonates induce apoptosis of stromal tumor cells in giant cell tumor of boneY Y Cheng
Department of Orthopaedics and Traumatology, Chinese University of Hong Kong, Shatin, N.T, Hong Kong SAR
Calcif Tissue Int 75:71-7. 2004..41% at 150 microM, followed by pamidronate (22.23%) and alendronate (15.3%). Our observations suggest that these drugs may be considered as potential adjuvants in the treatment of GCT...
- Surgical treatment of giant cell tumour of long bone with anhydrous alcohol adjuvantJoo Han Oh
Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, Seoul, South Korea
Int Orthop 30:490-4. 2006..Recurrence-free probability was 87.6% at final follow-up (13 years) after index surgery by Kaplan-Meyer analysis. Our data suggest that anhydrous alcohol can be used as an effective safe adjuvant for the treatment of GCT of long bone...
- Multiple skeletal metastases from a giant cell tumour of the distal fibula with fatal outcomeC I Leichtle
Orthopaedic Department, , Hoppe-Seyler-Str. 3, , Germany
J Bone Joint Surg Br 88:396-9. 2006..After a second recurrence and six years after the initial diagnosis, she rapidly developed multiple bony metastases. The outcome was fatal...
- Periacetabular limb salvage for malignant bone tumoursA Asavamongkolkul
Department of Orthopaedic Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
J Orthop Surg (Hong Kong) 13:273-9. 2005..To evaluate treatment outcomes in primary malignant periacetabular bone tumour removal and limb salvage with or without bone-graft reconstruction...
- Reconstruction following en bloc resection of a giant cell tumor of the distal radius using a vascularized pedicle graft of the ulnaC S Intuwongse
Department of Orthopaedic Surgery, Institute of Orthopaedics, Lerd Sin General Hospital, Bangkok, Thailand
J Hand Surg Am 23:742-7. 1998..It provides early bone union and improves stability of the wrist joint. Four cases of giant cell tumor were treated and all 4 cases had satisfactory results...
- Treatment of giant cell tumors with allograft transplants: a 30-year studyHenry J Mankin
Orthopaedic Oncology Service, Massachusetts General Hospital, Boston, MA 02114, USA
Clin Orthop Relat Res 439:144-50. 2005....
- Primary giant cell tumours of the digital bones of the handM Ropars
London Bone Tumour Unit, The Royal National Orthopaedic Hospital, Stanmore, Middlesex, London, UK
J Hand Surg Eur Vol 32:160-4. 2007..Our small series of cases supports a policy of aggressive primary surgery, including amputation or en bloc resection and reconstruction...
- Microsurgical fibular flap for pelvic ring reconstruction after periacetabular tumor resectionGuangrong Yu
Department of Orthopedic Surgery, Tongji University, Tongji Hospital, Shanghai, China
J Reconstr Microsurg 23:137-42. 2007..This report shows our experience in use of microsurgical fibular flaps for arthrodesis of the hip after periacetabular tumor resection, which restores the continuity of the pelvic ring with minimal shortening of the limb...
- [Functional reconstruction of the radial articular surface after giant cell tumor]I Warnecke
Klinik für Plastische, Rekonstruktive und Asthetische Chirurgie, Handchirurgie, Städtisches Klinikum Bielefeld Mitte, Bielefeld
Orthopade 36:679-82. 2007....
- Tibial giant cell tumor with distant subcutaneous metastasisRajendra S Garbyal
Acta Cytol 52:270-3. 2008
- Giant cell tumor of the distal radiusD S Sheth
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Hand Surg Am 20:432-40. 1995..En bloc excision with arthrodesis is more suitable for extensive local disease with poor residual bone stock and as salvage for failed intralesional excision...
- The use of fibular autograft and ankle arthrodesis for aggressive giant cell tumor in the distal tibia: a case reportYener Saglik
Department of Orthopaedics and Traumatology, Ankara University School of Medicine, Ankara, Turkey
Foot Ankle Int 29:438-41. 2008..In conclusion, due to the large resection that is often necessary for aggressive tumors, fibular autograft and ankle arthrodesis may be a useful method in the distal tibia...
- Microsurgical fibular graft for full-length radius reconstruction after giant-cell tumor resection: a case reportGuang Rong Yu
Department of Orthopedic Surgery, Tongji Hospital, Tongji University, 389 Xincun Road, 200 065 Shanghai, China
Microsurgery 25:121-5. 2005..With appropriate dynamic tendon transfer, this procedure can provide an alternative method for reconstruction of the full-length radius after tumor resection, with functional and durable results...
- Giant cell tumor of the cervical spine: a series of 22 cases and outcomesMa Junming
The Spine Center, Changzheng Hospital, The Second Military Medical University, Shanghai, People s Republic of China
Spine (Phila Pa 1976) 33:280-8. 2008..A consecutive series of 22 giant cell tumor (GCTs) of the cervical spine which underwent surgical treatment was observed from 1990-2003...
- Autogenous fibular graft and silicone implant arthroplasty following resection of giant cell tumor of the metacarpal: a report of two casesE A Athanasian
Department of Orthopedics, Mayo Clinic, Rochester, MN 55905, USA
J Hand Surg Am 22:504-7. 1997..At 2-year and 1-year follow-up evaluation, respectively, the patients were found to be doing well. This method of reconstruction appears reliable and presents the possibility for vascularized reconstruction if that is thought necessary...
- Giant cell tumor of bone in children and adolescentsAjay Puri
Tata Memorial Hospital, Mumbai, India
J Pediatr Orthop 27:635-9. 2007There are very few series that document giant cell tumor of bone (GCT) in the immature skeleton, and the reported incidence in literature varies from 1.8% to 10.6%...
- Clinicopathologic profile of 470 giant cell tumors of bone from a cancer hospital in western IndiaR Gupta
Department of Pathology, Tata Memorial Hospital, Parel, Mumbai 400012, India
Ann Diagn Pathol 12:239-48. 2008Over 20 years, 470 cases of giant cell tumor of bone diagnosed at a tertiary cancer hospital were analyzed. Male predominance (57%), predilection for bones around the knee joint (42%), and occurence in the 21- to 30-year-old age group (49...
- Giant-cell tumors of the carpusKoji Shigematsu
Department of Orthopaedic Surgery, Nara Medical University, Nara, Japan
J Hand Surg Am 31:1214-9. 2006..Intralesional procedures, such as curettage, were associated with a high incidence of recurrence (24%), whereas cases treated with an excisional procedure did not recur...
- Telomerase activity in giant cell tumors of boneToshihiro Matsuo
Department of Orthopaedic Surgery, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8551, Japan
Ann Surg Oncol 14:2896-902. 2007A giant cell tumor of bone (GCT) is a histologically benign neoplasma that has an unpredictable pattern of biological aggressiveness...
- Re-operation results in osteoarthritic change of knee joints in patients with giant cell tumor of boneYoshitaka Suzuki
Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
Knee 14:369-74. 2007b>Giant cell tumor of bone occasionally results in secondary osteoarthritic changes in adjacent joints...
- Iatrogenic seeding of a giant cell tumor of the patella to the proximal tibiaOnder Ofluoglu
Department of Orthopedics, Lutfi Kirdar Research Hospital, Istanbul, Turkey
Clin Orthop Relat Res 465:260-4. 2007..The cause and prevention of implantation metastasis are discussed and the basic principles of musculoskeletal tumor management emphasized...
- Ankle arthrodesis with bone graft after distal tibia resection for bone tumorsDomenico Andrea Campanacci
Foot Ankle Int 29:1031-7. 2008..Ankle arthrodesis has proven to be an effective treatment in primary and post-traumatic joint arthritis, but few papers have addressed the feasibility and techniques of ankle arthrodesis in tumor surgery after long bone resections...
- Cytotoxic effect of drugs eluted from polymethylmethacrylate on stromal giant-cell tumour cells: an in vitro studyD Gouran Savadkoohi
Pasteur Institute of Iran, Tehran, Iran
J Bone Joint Surg Br 90:973-9. 2008..Even in low doses, cytotoxic drugs mixed with polymethylmethacrylate cement could therefore be considered as effective local adjuvant treatment for GCTs...
- What's new in musculoskeletal oncologyValerae O Lewis
MD Anderson Cancer Center, P.O. Box 301402, Unit 408, Houston, TX 77230-1402, USA
J Bone Joint Surg Am 89:1399-407. 2007
- Management of grade III giant cell tumors of bonesHsien-Chung Wang
Department of Orthopedic Surgery, Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
J Surg Oncol 92:46-51. 2005....
- Pulmonary metastases of giant cell tumour of the boneW I Faisham
Musculoskeletal Oncology Unit, School of Medical Science, University Sains Malaysia, Kubang Kerian, Kelantan
Med J Malaysia 59:78-81. 2004..Early detection and treatment of this tumour is important as complete resection of this tumour have favourable prognosis. Multiple lung nodules which preclude resection may remain dormant and asymptomatic with systemic chemotherapy...
- Multifocal metachronous giant cell tumor in a 15-year-old boyPeter G Stratil
Department of Radiology, University of Chicago Hospitals, MC 2026, 5841 South Maryland, Chicago, IL 60610, USA
Pediatr Radiol 35:444-8. 2005..Pediatric radiologists should be aware of this when encountering a single lesion with characteristic radiographic features of GCT and when encountering multiple lytic skeletal lesions...
- [Reconstruction of the distal radius for primary bone tumors using a non-vascularized fibular graft (report of 4 cases)]M Rtaimate
Clinique Lille-Sud, SOS Mains, rue Gustave Delory, 59000 Lesquin, France
Chir Main 20:272-9. 2001..Bone graft healing occurred at a mean of six months with a range of from four to nine months. Resection followed by a non-vascularised fibular graft is an effective way to managing these patients...
- Giant cell tumor of the distal fibula: fifteen-year result after en bloc resection and fibula reconstructionWolfgang Eger
Department of Orthopaedic Surgery at Rummelsberg Hospital, Rummelsberg, Schwarzenbruck Nürnberg, Germany
Arch Orthop Trauma Surg 124:56-9. 2004..Giant cell tumor of the distal fibula is a very rare condition. The treatment of advanced tumors at this location can be challenging and has been described in the literature only in single cases...
- Bone imaging in "giant" giant cell tumorC P Wong
Department of Nuclear Medicine, Queen Elizabeth Hospital, Hong Kong
Clin Nucl Med 29:509-13. 2004
- Neoplastic and tumorlike lesions detected on MR imaging of the knee in patients with suspected internal derangement: Part I, intraosseous entitiesGregory S Stacy
Department of Radiology, The University of Chicago Hospitals, 5841 S. Maryland Ave, MC 2026, Chicago, IL 60637, USA
AJR Am J Roentgenol 178:589-94. 2002
- [Giant cell tumor--osteoclastoma: part II]J Kordos
, FN, SPAM, Bratislava
Acta Chir Orthop Traumatol Cech 68:141-7. 2001..In case of extensive destruction in the region of joints the method of choice is the application of both individual and total replacement...
- Giant cell tumour of the first metacarpalAbdul Basit
Department of Orthopaedic Surgery, Liaquat National Hospital, Stadium Road, Karachi
J Coll Physicians Surg Pak 14:374-5. 2004..A case report of lytic lesion of the first metacarpal bone is presented, which was a conventional grade III giant cell tumour. It was excised and reconstructed by a free fibular graft with gratifying result after three years follow-up...
- Aneurysmal bone cyst: a hereditary disease?Andreas Leithner
Department of Orthopaedic Surgery, Karl Franzens University, Auenbruggerplatz 9, A 8036 Graz, Austria
J Pediatr Orthop B 13:214-7. 2004..These data indicate that a predisposing genetic defect could be part of a multifactorial pathogenesis in the development of some aneurysmal bone cysts...
- [Limb salvage surgery for wrist in bone tumor by using free vascularised fibular graft with fibular head or simple fibular graft]Chao Qi
Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P. R. China
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 18:165-7. 2004..So in the procedure for reconstruction and limb salvage after bone tumor resection of distal radius, the free vascularised fibular graft with fibular head is an ideal substitute...
- [Multicentric giant cell tumor of the upper arm]M Hamdi
, , Tunisie
Acta Orthop Belg 68:87-92. 2002..The histologic study confirmed the diagnosis of giant cell tumor of similar grade. After 13 years follow-up, the patient had a satisfactory function of the limb and no recurrence of the tumor was noted...
- Management of the giant-cell tumours of the distal radiusM T Khan
Department of Orthopaedic Oncology, The Royal Orthopaedic Hospital, Birmingham, UK
Ann R Coll Surg Engl 86:18-24. 2004..In the present series, we report the results of curettage only as the treatment for primary giant-cell tumour of the distal radius carried out at a single centre...
- Subchondral giant-cell tumor of the proximal tibia: arthroscopic treatment for accelerated articular cartilage and meniscal degeneration in two patientsSamir G Tejwani
Department of Orthopaedic Surgery, University of California, Los Angeles School of Medicine, Los Angeles, California 90095, USA
Arthroscopy 20:644-9. 2004..Repetitive heavy loading of the knee, such as running, was prohibited, and long-term follow-up is warranted to assess for further joint degeneration and need for total knee arthroplasty...
- Reconstruction of the distal radius by fibula following excision of giant cell tumorV K Aithal
Department of Orthopedics, Nizwa Hospital, P O Box 1222, Sultanate of Oman
Int Orthop 27:110-3. 2003..2 months. The surgical technique using a radiofibular plate and K wire through the wrist had a low nonunion rate, no graft related complications, good range of movement, and good hand functions...
- Giant cell tumor of boneAlan W Yasko
Department of Orthopedic Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 444, Houston, TX 77030, USA
Curr Oncol Rep 4:520-6. 2002b>Giant cell tumor of bone is an enigmatic osseous neoplasm that is histologically benign but clinically shows local aggression and metastatic potential...
- Fine needle aspiration cytology diagnosis of pulmonary metastasis from giant-cell tumour of boneBabu Nagesh
Cytopathology 13:256-7. 2002
- Fibulo-scapho-lunate arthrodesis as a motion-preserving procedure after tumour resection of the distal radiusB Bickert
Department of Hand, Plastic and Reconstructive Surgery, BG Trauma Center Ludwigshafen, Germany
J Hand Surg Br 27:573-6. 2002..Fibulo-scapho-lunate fusion represents an alternative. This reconstruction in two patients provided excellent wrist stability and a functional range of midcarpal motion...
- Radiologic case study. Giant-cell tumor of the wrist in a skeletally immature girlJérĵme Cottalorda
Department of Orthopedic Pediatric Surgery, University School of Medicine, Saint Etienne, France
Orthopedics 25:470, 550-2. 2002
- Vascularized fibular graft after excision of giant-cell tumor of the distal radius: wrist arthroplasty versus partial wrist arthrodesisAkio Minami
Department of Orthopaedic Surgery, Hokkaido University School of Medicine, Kita 15, Nishi 7, Kita ku Sapporo, Hokkaido 060 8638, Japan
Plast Reconstr Surg 110:112-7. 2002....
- Comparison of the degenerative changes in weight-bearing joints following cementing or grafting techniques in giant cell tumour patients: medium-term resultsK Szalay
Orthopaedic Clinic of Semmelweis University, Budapest, Hungary
Int Orthop 30:505-9. 2006....
- Allograft replacement in limb salvage surgery for bone tumorsP Itiravivong
Department of Orthopaedics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
J Med Assoc Thai 84:S396-400. 2001..Though psychosocial benefit was gained in patients with this limb salvage procedure, functional evaluation did not yield a satisfactory result...
- Principles of limb salvage surgery of the upper extremityMichael E Leit
Department of Orthopaedic Surgery, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
Hand Clin 20:v, 167-79. 2004..Because preservation of hand function, even modest levels thereof, is clearly superior to amputation from a functional standpoint, the authors review the principles of limb salvage in this article...
- Molecular Mechanisms in Bone ResorptionSTEVEN LIETMAN; Fiscal Year: 2009..New information about mechanisms of bone resorption may facilitate the development of novel strategies to decrease bone resorption and may lead to new treatments for osteoporosis. ..
- RANK-Associated Inhibitor (RAIN) in Osteoclast FormationBryant Darnay; Fiscal Year: 2007..and have been implicated in various diseases, which include rheumatoid arthritis, osteoporosis, giant cell tumor of bone, Paget's disease, metastatic breast cancer, multiple myeloma, and familial expansile osteolysis...
- Bioengineering Annulus Fibrosus using Silk ScaffoldRita Kandel; Fiscal Year: 2006..The viability and mechanical properties of the tissue will be evaluated. ..
- Molecular Mechanisms of Ectopic Bone FormationSTEVEN LIETMAN; Fiscal Year: 2006..abstract_text> ..
- METABOLISM IN NORMAL AND OSTEOARTHRITIC CARTILAGEHenry Mankin; Fiscal Year: 1991..The receptors for this cytokine on normal and OA chondrocytes will be quantitated. Further definition of these cartilage metabolic pathways are of primary importance in our understanding of osteoarthritis...
- Minimally Invasive Approaches for Craniofacial SurgeryMaria Troulis; Fiscal Year: 2005..abstract_text> ..
- INVESTIGATING THE MECHANISMS OF PRB TUMOR SUPPRESSIONArnab Chakravarti; Fiscal Year: 2003..Specific Aim number 3: To determine whether the deregulation of E2F dependent transcription is correlated with the tumorigenic potential of RB -/- cells in-vivo. ..
- METABOLISM IN NORMAL AND OSTEOARTHRITIC CARTILAGEHenry Mankin; Fiscal Year: 2001..It is further speculated that the study of serine proteinases produced by OA cartilage may have strong implications for the management of this debilitating disease. ..
- Molecular Mechanisms in Bone ResorptionSteven A Lietman; Fiscal Year: 2010..New information about mechanisms of bone resorption may facilitate the development of novel strategies to decrease bone resorption and may lead to new treatments for osteoporosis. ..