Genomes and Genes
giant cell tumor of bone
Summary: A bone tumor composed of cellular spindle-cell stroma containing scattered multinucleated giant cells resembling osteoclasts. The tumors range from benign to frankly malignant lesions. The tumor occurs most frequently in an end of a long tubular bone in young adults. (From Dorland, 27th ed; Stedman, 25th ed)
Publications219 found, 100 shown here
- [Giant cell tumor of bone with rapid malignant course]M R Lachat
Klinik für Rheumatologie und Rehabilitation, Stadtspital Triemli, Zurich, Switzerland
Orthopade 33:344-8. 2004..Following the diagnosis of giant cell tumor of bone (GCT) on biopsy and curettage, a rapid malignant course was observed with recurrence 2.5 months later...
- Giant cell tumor of bone: risk factors for recurrenceFrank M Klenke
Department of Orthopedic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Clin Orthop Relat Res 469:591-9. 2011Many surgeons treat giant cell tumor of bone (GCT) with intralesional curettage. Wide resection is reserved for extensive bone destruction where joint preservation is impossible or when expendable sites (eg, fibular head) are affected...
- Giant cell tumor of the extremity: A review of 349 cases from a single institutionCostantino Errani
Musculoskeletal Oncology Department, Istituto Ortopedico Rizzoli, Bologna, Italy
Cancer Treat Rev 36:1-7. 2010..Special attention must be given to giant cell tumors not only in the distal radius, but also in the proximal femur, where the treatment is more difficult and associated with a higher rate of local recurrence...
- The origin of the neoplastic stromal cell in giant cell tumor of boneManuela Wülling
Department of Bone Pathology Center of Biomechanics, University Hospital Hamburg Eppendorf, Germany
Hum Pathol 34:983-93. 2003Fibroblastlike stromal cells, which are always present as a component of giant cell tumor of bone (GCT), can be observed in both in vivo and cultured cell samples...
- Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 studyDavid Thomas
Peter MacCallum Cancer Centre, East Melbourne, Vic, Australia
Lancet Oncol 11:275-80. 2010..We investigated the potential therapeutic effect of denosumab, a fully human monoclonal antibody against RANKL, on tumour-cell survival and growth in patients with GCT...
- Gene expression profiling identifies p63 as a diagnostic marker for giant cell tumor of the boneCheng Han Lee
Department of Pathology, Stanford University, Stanford, CA, USA
Mod Pathol 21:531-9. 2008..These findings altogether show that p63 can be used as a diagnostic marker to aid the clinical diagnosis of GCTOB...
- RANK (receptor activator of nuclear factor kappa B) and RANK ligand are expressed in giant cell tumors of boneSophie Roux
Rheumatology Department, Bicetre Hospital, Le Kremlin Bicetre, France
Am J Clin Pathol 117:210-6. 2002..Our results suggest that RANKL expression may have a role in the pathogenesis of GCTBs and in the formation of the large OC population present in these tumors...
- Giant cell tumour of the sacrum: a suggested algorithm for treatmentRajkumar Thangaraj
The Royal Orthopaedic Hospital Oncology Service, Bristol Road South, Birmingham, B31 2AP, UK
Eur Spine J 19:1189-94. 2010..Embolisation and curettage are the preferred first option with radiotherapy as a possible adjunct. Spinopelvic fusion may be needed when the sacrum collapses...
- Clonality studies in giant cell tumor of boneH S Schwartz
Vanderbilt University, Department of Orthopaedics and Rehabilitation, Nashville, Tennessee 37232 2550, USA
J Orthop Res 20:387-90. 2002..Seventeen female patients with giant cell tumor of bone had their DNA harvested and their X-chromosome inactivation pattern and polymorphisms determined and ..
- A case of recurrent giant cell tumor of bone with malignant transformation and benign pulmonary metastasesIra J Miller
Department of Orthopedic Surgery, Rush University Medical Center, 1611 W, Harrison 300 Chicago, IL, 60612, USA
Diagn Pathol 5:62. 2010..Here we report a case of GCT of bone that at the time of recurrence was found to have undergone malignant transformation. Concurrent metastases were found in the lung, but these were non-transformed GCT...
- Identification of potential biomarkers for giant cell tumor of bone using comparative proteomics analysisAmalia Conti
Laboratory of Experimental Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy
Am J Pathol 178:88-97. 2011b>Giant cell tumor of bone can be locally aggressive and occasionally can metastasize in the lungs...
- Giant cell tumor of bone: treatment and outcome of 214 casesMaurice Balke
Department of Orthopedic Surgery, University of Muenster, Muenster, Germany
J Cancer Res Clin Oncol 134:969-78. 2008Two hundred and fourteen patients with benign giant cell tumor of bone (GCTB), treated from 1980 to 2007 at the Department of Orthopedics of the University of Muenster (Germany), were analyzed in a retrospective study.
- p63 expression in giant cell-containing lesions of bone and soft tissueGustavo de la Roza
Department of Pathology, Upstate University Hospital, Syracuse, New York, USA
Arch Pathol Lab Med 135:776-9. 2011..Although routine histology is often all that is required to diagnose giant cell tumor of bone, immunohistochemistry could prove useful to distinguish it from other benign and malignant giant cell-..
- Which treatment is the best for giant cell tumors of the distal radius? A meta-analysisYu Peng Liu
Department of Orthopaedics, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, PR China
Clin Orthop Relat Res 470:2886-94. 2012..However, it is unclear whether one provides lower rates of recurrences and fewer complications, and whether the use of polymethylmethacrylate (PMMA) after curettage reduces the risk of recurrence...
- Factors of local recurrence of giant cell tumor of long bone after treatment: plain radiographs, pathology and surgical proceduresKullanuch Chanchairujira
Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University Bangkok, Thailand
J Med Assoc Thai 94:1230-7. 2011..To evaluate the relationship between local recurrence of giant cell tumor (GCT) after surgical treatments and plain radiography, pathology grade and surgical procedures...
- Giant cell tumor of bone express p63Brendan C Dickson
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada
Mod Pathol 21:369-75. 2008..The purpose of this study was to investigate p63 expression in giant cell tumor of bone and to determine whether it can be used to discriminate between other giant cell-rich tumors...
- The efficacy of chemical adjuvants on giant-cell tumour of bone. An in vitro studyY Gortzak
Mount Sinai Hospital, Toronto, Canada
J Bone Joint Surg Br 92:1475-9. 2010..No multinucleated cell formation was seen in these cultures. These results suggest that the use of chemical adjuvants other than water could help improve local control in the treatment of GCT of bone...
- A clinicopathological study of giant cell tumor of small bonesMichiro Yanagisawa
Department of Orthopedic Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
Ups J Med Sci 116:265-8. 2011..The purpose of this study was to investigate and report the clinicopathological features of 11 cases with small-bone GCT...
- Phenol as an adjuvant for local control in the treatment of giant cell tumour of the boneH R Dürr
Department of Orthopedics and Orthopedic Surgery, Ludwig Maximilians University Munich, Klinikum Grosshadern, Marchioninistr 15, Munich, D 81366, Germany
Eur J Surg Oncol 25:610-8. 1999..Due to the combined use of phenol and cementation in most studies, the effect of phenol alone is described in this study...
- Upregulation of MMP-13 via Runx2 in the stromal cell of Giant Cell Tumor of boneIsabella W Y Mak
Department of Surgery, McMaster University, Hamilton, Ontario, Canada
Bone 45:377-86. 2009b>Giant Cell Tumor of bone (GCT) is an aggressively osteolytic and cytokine-rich bone tumor...
- Properties of the stromal cell in giant cell tumor of boneMichelle Ghert
McMaster University, Hamilton Health Sciences and the Juravinski Cancer Centre, Hamilton, Ontario, Canada
Clin Orthop Relat Res 459:8-13. 2007..The spindle like stromal cells of GCT have characteristics of osteoblast progenitors and produce active matrix-degrading proteases. These cells may therefore play a central role in bone destruction...
- Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of boneIsabella W Y Mak
McMaster University, Hamilton, Ontario, Canada L8V 5C2
Hum Pathol 41:1320-9. 2010b>Giant cell tumor of bone (GCT) is an aggressively osteolytic primary bone tumor that is characterized by the presence of abundant multinucleated osteoclast-like giant cells, hematopoietic monocytes, and a distinct mesenchymal stromal cell ..
- Cathepsin K is the principal protease in giant cell tumor of boneJan H N Lindeman
Department of Biomedical Research, TNO Prevention and Health, PO Box 2215, 2301 CE Leiden, The Netherlands
Am J Pathol 165:593-600. 2004..Inhibition of cathepsin K or its associated proton-pump may provide new therapeutic opportunities for GCT...
- Local recurrence of giant cell tumor of bone after intralesional treatment with and without adjuvant therapyWolfgang T Becker
Orthopädische Klinik Volmarstein, Universitat Witten Herdecke, Wetter, Germany
J Bone Joint Surg Am 90:1060-7. 2008The use of adjuvants after curettage has been well established for the treatment of giant cell tumor of bone. The purpose of this study was to analyze the rates of recurrence following different types of treatment as well as the influence ..
- Giant cell tumour of boneDavid M Thomas
Departments of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Curr Opin Oncol 21:338-44. 2009..Giant cell tumour of bone (GCT) is the most common benign bone tumour and afflicts a young population. Treatment options for patients with unresectable disease have remained fairly static for the past three decades...
- Histogenetic characterization of giant cell tumor of boneManuela Salerno
Laboratory for Pathophysiology, Istituto Ortopedico Rizzoli, 40136 Bologna, Italy
Clin Orthop Relat Res 466:2081-91. 2008..The increased number of giant cells in GCT may be secondary to an autocrine circuit mediated by the receptor activator of nuclear factor kB...
- Functional outcome of en bloc excision and osteoarticular allograft replacement with the Sauve-Kapandji procedure for Campanacci grade 3 giant-cell tumor of the distal radiusRobert M Szabo
Department of Orthopaedic Surgery, School of Medicine, University of California, Davis, Sacramento, 95817, USA
J Hand Surg Am 31:1340-8. 2006..The purpose of this study was to assess with validated patient outcome surveys the intermediate to long-term outcomes of all patients treated with this surgery and to analyze their functional results and document tumor control...
- Metastatic giant cell tumor of bone: are there associated factors and best treatment modalities?Seethalakshmi Viswanathan
Department of Pathology, Tata Memorial Hospital, Parel, Mumbai 400012, India
Clin Orthop Relat Res 468:827-33. 2010..None of the patients died of their metastatic disease. None of the risk factors we studied was associated with metastasis in giant cell tumors. Although the overall outcome was favorable, metastasectomy is recommended where feasible...
- Joint salvage for pathologic fracture of giant cell tumor of the lower extremityBenjamin M Deheshi
University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Ontario, Canada
Clin Orthop Relat Res 459:96-104. 2007..Joint salvage for patients with pathologic fractures through giant cell tumor of weightbearing bones is a reasonable option with functional outcomes and recurrence rates comparable to those of patients without fracture...
- CCAAT/enhancer binding protein beta is up-regulated in giant cell tumor of bone and regulates RANKL expressionPatrick Kwok Shing Ng
School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR
J Cell Biochem 110:438-46. 2010....
- Treatment options for recurrent giant cell tumors of boneMaurice Balke
Department of Orthopedic Surgery, University of Muenster, Albert Schweitzer Str 33, 48149, Munster, Germany
J Cancer Res Clin Oncol 135:149-58. 2009..The possible surgical procedures range from repeated intralesional curettage to wide resection...
- Regulation of MMP-9 (92 kDa type IV collagenase/gelatinase B) expression in stromal cells of human giant cell tumor of boneV H Rao
Meyer Rehabilitation Institute and Department of Pediatrics, University of Nebraska Medical Center, Omaha 68198, USA
Clin Exp Metastasis 15:400-9. 1997..This suggests that multinucleated giant cells in primary cultures secrete a factor(s) that stimulates stromal cells to produce MMP-9, which, in turn, may contribute to the aggressive behavior of GCT...
- Metastasis of giant cell tumor to the breast: case report and review of the literatureAhmet Alacacioglu
Institute of Oncology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey
Tumori 92:351-3. 2006....
- Argon beam coagulation as an adjuvant for local control of giant cell tumorValerae O Lewis
MD Anderson Cancer Center, Houston, TX, USA
Clin Orthop Relat Res 454:192-7. 2007..These data suggest argon beam coagulation as an adjuvant therapy is associated with in a low rate of local recurrence and is a reasonable adjuvant treatment option...
- Ethanol as a local adjuvant for giant cell tumor of boneKevin B Jones
Department of Orthopaedics and Rehabilitation, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 01051 John Pappajohn Pavilion, Iowa City, IA 52242, USA
Iowa Orthop J 26:69-76. 2006..Until such evidence becomes available, the use of adjuvant ethanol offers a compromise between higher toxicity adjuvants and no chemical adjuvant at all...
- [Giant cell tumor at the wrist: a review of 23 cases]Tackin Ozalp
Celal Bayar Universitesi Tip Fakültesi Ortopedi ve Travmatoloji Anabilim Dali
Acta Orthop Traumatol Turc 40:144-50. 2006....
- PTHrP increases RANKL expression by stromal cells from giant cell tumor of boneRobert W Cowan
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
J Orthop Res 30:877-84. 2012b>Giant cell tumor of bone (GCT) presents with numerous osteoclast-like multinucleated giant cells that are principally responsible for the extensive bone resorption by the tumor...
- Giant cell tumor of bone. The role of fibroblast growth factor 3 positive mesenchymal stem cells in its pathogenesisDror Robinson
Department of Orthopedics A Assaf Harofeh Medical Center, Zerifin, Israel
Pathobiology 70:333-42. 2002b>Giant cell tumor of bone is typified by massive infiltration of a bland neoplastic stroma by osteoclasts and monocyte progenitors...
- Expression of bone morphogenetic proteins in giant cell tumor of boneNaoko Kudo
Division of Orthopedic Surgery, Department of Regenerative Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Niigata 951 8510, Japan
Anticancer Res 29:2219-25. 2009..Although the bone formation in GCT in supposedly due to bone morphogenetic proteins (BMPs), the expression pattern of BMPs in GCT has not been well investigated...
- Does the addition of cement improve the rate of local recurrence after curettage of giant cell tumours in bone?C L Gaston
Royal Orthopaedic Hospital NHS Foundation Trust, Bristol Road South, Northfield, Birmingham B31 2AP, UK
J Bone Joint Surg Br 93:1665-9. 2011..001). In patients who developed local recurrence, 75.0% (9 of 12) of those with previous cementation required a joint replacement, compared with 45.2% (33 of 73) of those without cement (p = 0.044)...
- Histological and clinical characteristics of malignant giant cell tumor of boneLihua Gong
Department of Pathology, Beijing Jishuitan Hospital, Fourth Medical College of Peking University, Teaching Hospital of Tsinghua University, 31 Xinjiekou East Street, Xicheng District, Beijing 100035, China
Virchows Arch 460:327-34. 2012..Five cases were primary malignant giant cell tumor of bone (PMGCTB), and 12 cases were giant cell tumors of bone initially diagnosed as benign but malignant in a ..
- A short-term in vivo model for giant cell tumor of boneMaurice Balke
Department of Trauma and Orthopedic Surgery, University of Witten Herdecke, Cologne Merheim Medical Center, Ostmerheimer Str, Cologne, Germany
BMC Cancer 11:241. 2011Because of the lack of suitable in vivo models of giant cell tumor of bone (GCT), little is known about its underlying fundamental pro-tumoral events, such as tumor growth, invasion, angiogenesis and metastasis...
- Giant cell tumor of bone with pulmonary metastasesYasuhiro Okamoto
Med Pediatr Oncol 41:454-9. 2003
- Giant cell tumor of boneAlan W Yasko
Department of Orthopedic Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 444, Houston, TX 77030, USA
Curr Oncol Rep 4:520-6. 2002b>Giant cell tumor of bone is an enigmatic osseous neoplasm that is histologically benign but clinically shows local aggression and metastatic potential...
- Bisphosphonates induce apoptosis of stromal tumor cells in giant cell tumor of boneY Y Cheng
Department of Orthopaedics and Traumatology, Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR
Calcif Tissue Int 75:71-7. 2004..41% at 150 microM, followed by pamidronate (22.23%) and alendronate (15.3%). Our observations suggest that these drugs may be considered as potential adjuvants in the treatment of GCT...
- Giant cell tumour of bone: morphological, biological and histogenetical aspectsMathias Werner
Institute of Osteopathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Int Orthop 30:484-9. 2006..Further research of the pathogenesis of GCT as well as the complex interactions of its cellular populations may provide the knowledge necessary for developing approaches for a biological-based therapy of this neoplasm...
- Hip joint remodeling in an adult following excision of a giant cell tumor involving the acetabulum: a case report and literature reviewHideji Nishida
Department of Orthopedic Surgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
Arch Orthop Trauma Surg 126:458-63. 2006We describe a 47-year-old man with a giant cell tumor of bone involving the acetabulum treated with curettage and bone grafting which resulted in good remodeling of the hip joint...
- [Clinicopathologic study of giant cell angioblastoma]Rong Jun Mao
Department of Pathology, Foshan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Foshan 528000, China
Zhonghua Bing Li Xue Za Zhi 39:752-6. 2010..to study the clinicopathological features, imaging characteristics, immunophenotypes and differential diagnosis of giant cell angioblastoma (GCAB)...
- Pamidronate, farnesyl transferase, and geranylgeranyl transferase-I inhibitors affects cell proliferation, apoptosis, and OPG/RANKL mRNA expression in stromal cells of giant cell tumor of boneCarol P Y Lau
Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Room 74034 5 F, Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong
J Orthop Res 29:403-13. 2011..Our findings support that the combination of bisphosphonates with GGTIs or FTIs with GGTIs may be used as potential adjuvants in the treatment of GCT of bone...
- Giant cell tumor of the extremity: retrospective analysis of 621 Chinese patients from one institutionXiaohui Niu
Department of Orthopedic Oncology Surgery, Beijing Ji Shui Tan Hospital, Peking University, 31 Xinjiekou East Street, Xicheng District, Beijing 100035, China
J Bone Joint Surg Am 94:461-7. 2012..The present study was designed to review the epidemiological characteristics and outcomes of surgical management in a large series of Chinese patients with giant cell tumor of an extremity, treated at a single institution...
- Soft tissue extension increases the risk of local recurrence after curettage with adjuvants for giant-cell tumor of the long bonesL van der Heijden
Department of Orthopaedic Surgery, Leiden University Medical Center, The Netherlands
Acta Orthop 83:401-5. 2012..The aim of the study was the identification of individual risk factors after curettage with adjuvants in GCTB...
- The role of TWIST as a regulator in giant cell tumor of boneShalini Singh
Department of Surgery, McMaster University, Hamilton, Ontario, Canada
J Cell Biochem 112:2287-95. 2011b>Giant cell tumor of bone (GCT) is an aggressive tumor consisting of multinucleated osteoclast-like giant cells and proliferating osteoblast-like stromal cells...
- Giant cell tumor of bone: a basic science perspectiveRobert W Cowan
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
Bone 52:238-46. 2013Comprehending the pathogenesis of giant cell tumor of bone (GCT) is of critical importance for developing novel targeted treatments for this locally-aggressive primary bone tumor...
- Giant Cell Tumor (tumor gigantocellularis, osteoclastoma) - epidemiology, diagnosis, treatmentMarta Karpik
Department of Clinical Orthopaedics and Traumatology, Medical University Hospital in Białystok
Ortop Traumatol Rehabil 12:207-15. 2010..b>Giant Cell Tumor of Bone accounts for 4-8% of primary bone tumors. It is most commonly seen in women aged 20 to 40 years...
- Differentially expressed genes in giant cell tumor of boneErica Babeto
Laboratory of Genomics Studies, Sao Paulo State University UNESP, Cristóvão Colombo, 2265, 15054 000, Sao Jose do Rio Preto, SP, Brazil
Virchows Arch 458:467-76. 2011....
- Interferon alfa-2b for recurrent and metastatic giant cell tumor of the spine: report of two casesFeng Wei
Department of Orthopedics, Peking University Third Hospital, Beijing, China
Spine (Phila Pa 1976) 35:E1418-22. 2010..Case report...
- Recruitment of osteoclast precursors by stromal cell derived factor-1 (SDF-1) in giant cell tumor of boneTed S Liao
Center for Orthopaedic Research, Department of Orthopaedic Surgery, Columbia University, 622 W 168th Street, BHN816, New York, NY 10032, USA
J Orthop Res 23:203-9. 2005..These results suggest that SDF-1 is one of the significant chemoattractant factors involved in the recruitment of hematopoietic osteoclast precursor cells during tumor-induced osteoclastogenesis...
- The treatment of sacral giant-cell tumours by serial arterial embolisationR D Lackman
Department of Orthopaedic Surgery, The Hospital of the University of Pennsylvania, Philadelphia 19104, USA
J Bone Joint Surg Br 84:873-7. 2002..They remained free from growth, recurrence, or metastases at follow-up (4 to 17 years). One patient died from metastatic disease within 18 months of the initial diagnosis...
- Giant cell tumor of the sternum: a case report and review of the literatureHiroyuki Futani
Department of Orthopaedic Surgery, Hyogo College of Medicine, 1 1 Mukogawa Nishinomiya, Hyogo 663 8501, Japan
Anticancer Res 28:4117-20. 2008..The initial treatment should be extended curettage followed by filling with PMMA...
- Morphological and immunophenotypic features of primary and metastatic giant cell tumour of boneM Alberghini
Istituto Ortopedico Rizzoli, Bologna, Italy
Virchows Arch 456:97-103. 2010..Our findings suggest that most lung nodules associated with primary conventional GCTBs are implants derived from tumour emboli formed in areas of haemorrhage and thrombus formation within the primary tumour...
- Bisphosphonates reduce local recurrence in extremity giant cell tumor of bone: a case-control studyLung Fung Tse
Department of Orthopaedics and Traumatology, Prince of Wales Hospital, Shatin, Hong Kong
Bone 42:68-73. 2008..Therefore our clinical study aims to investigate whether the administration of bisphosphonate as an adjuvant can further decrease local recurrence following the surgical treatment of GCT of bone...
- Bisphosphonate treatment of aggressive primary, recurrent and metastatic Giant Cell Tumour of BoneMaurice Balke
Department of Orthopaedic Surgery, University of Munster, Munster, Germany
BMC Cancer 10:462. 2010..GCTB frequently recurs and can produce metastatic lesions in the lungs. Bisphosphonates are anti-resorptive drugs which act mainly on osteoclasts...
- Giant-cell tumors of bone: an analysis of 87 casesYu Ping Su
Department of Orthopaedics and Traumatology, Veterans General Hospital, 201, Sec 2, Shih Pai Road, 112, Taipei, Taiwan, ROC
Int Orthop 28:239-43. 2004..Functional outcome was evaluated using the Enneking scoring system. Average rating was 86% for the lower extremity and 83% for the upper extremity. The overall satisfactory rate was 88%...
- Antiangiogenic therapy with interferon alpha for giant cell lesions of the jawsLeonard B Kaban
Walter C Guralnick Professor and Chairman, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital and Harvard School of Dental Medicine, Boston 02114, USA
J Oral Maxillofac Surg 60:1103-11; discussion 1111-3. 2002..The purpose of this report is to present a treatment protocol consisting of enucleation, with preservation of vital structures, followed by subcutaneous interferon alpha...
- Histologically verified lung metastases in benign giant cell tumours--14 cases from a single institutionM Dominkus
University Clinic of Vienna, Department of Orthopaedics, Allgemeines Krankenhaus der Stadt Wien, Vienna, Austria
Int Orthop 30:499-504. 2006..We conclude that even metastatic benign giant cell tumours have an excellent prognosis after adequate resection. No prognostic factors despite high-grade lesions were detectable...
- Molecular profiling of giant cell tumor of bone and the osteoclastic localization of ligand for receptor activator of nuclear factor kappaBTeresa Morgan
Ian Potter Foundation Center for Cancer Genomics and Predictive Medicine and Research Division, Peter MacCallum Cancer Center, Melbourne, Australia
Am J Pathol 167:117-28. 2005b>Giant cell tumor of bone (GCT) is a generally benign, osteolytic neoplasm comprising stromal cells and osteoclast-like giant cells...
- Reconstruction of the distal radius by fibula following excision of giant cell tumorV K Aithal
Department of Orthopedics, Nizwa Hospital, P O Box 1222, Sultanate of Oman
Int Orthop 27:110-3. 2003..2 months. The surgical technique using a radiofibular plate and K wire through the wrist had a low nonunion rate, no graft related complications, good range of movement, and good hand functions...
- Giant-cell tumour of boneM Szendroi
Department of Orthopaedics, Semmelweis University, Budapest, Hungary
J Bone Joint Surg Br 86:5-12. 2004
- Giant cell tumor of boneWilliam M Mendenhall
Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA
Am J Clin Oncol 29:96-9. 2006..To discuss the treatment and outcomes for giant cell tumor (GCT) of bone...
- Giant cell tumor of boneRobert E Turcotte
Division of Orthopaedic Surgery, McGill University, Montreal, Quebec, Canada
Orthop Clin North Am 37:35-51. 2006..Preferred treatment usually consists of extensive curettage and filling of the cavity with bone graft or cement. Debate still exists about the usefulness of local adjuvant treatment. Functional outcome is usually very good...
- Phenotypic and molecular studies of giant-cell tumors of bone and soft tissueYu Sin Lau
Department of Pathology, University of Oxford, Nuffield Orthopaedic Centre, OX3 7LD Oxford, UK
Hum Pathol 36:945-54. 2005..Inhibitors of osteoclast formation and activity are likely to be effective in controlling the osteolysis associated with GCTB and possibly other giant-cell-rich lesions...
- Cytogenetic analysis of 101 giant cell tumors of bone: nonrandom patterns of telomeric associations and other structural aberrationsLudmila Gorunova
Department of Medical Genetics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
Genes Chromosomes Cancer 48:583-602. 2009b>Giant cell tumor of bone (GCTB) is a benign but locally aggressive tumor with metastatic potential. We performed cytogenetic analysis on 101 GCTB from 92 patients...
- Impact severity of local recurrence in giant cell tumor of boneRichard L McGough
From the University of Texas M D Anderson Cancer Center, Department of Orthopaedic Oncology, Houston, TX
Clin Orthop Relat Res 438:116-22. 2005..Despite its benign histology, giant cell tumor of bone is an aggressive tumor that demands meticulous attention to surgical detail and close postoperative ..
- Cement is recommended in intralesional surgery of giant cell tumors: a Scandinavian Sarcoma Group study of 294 patients followed for a median time of 5 yearsAarne H Kivioja
Department of Orthopedics and Traumatology, Helsinki University Central Hospital, Helsinki, Finland
Acta Orthop 79:86-93. 2008..Giant cell tumors of bone rarely metastasize but often recur locally after surgery. There is limited knowledge about the risk of recurrence related to different types of treatment...
- [Giant cell tumor of bone and malignancies in giant cell tumor: a clinicopathologic analysis]Li hua Gong
Department of Pathology, Beijing Jishuitan Hospital, Beijing 100035, China
Zhonghua Bing Li Xue Za Zhi 38:312-5. 2009..To study the clinicopathologic features, diagnosis and differential diagnosis of malignancies in giant cell tumor (MGCT)...
- Primary malignant giant-cell tumor of bone has high survival rateStepan V Domovitov
Orthopaedic Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, USA
Ann Surg Oncol 17:694-701. 2010..This study compared malignant to benign GCTs and defined the clinical outcome of the patients in a large series of case-matched patients from a single institution...
- Genomic instability in giant cell tumor of bone. A study of 52 cases using DNA ploidy, relocalization FISH, and array-CGH analysisLinda Moskovszky
1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Ulloi ut 26, Budapest 1085, Hungary
Genes Chromosomes Cancer 48:468-79. 2009Genetic instability in relation to clinical behavior was studied in 52 cases of giant cell tumor of bone (GCTB). Ploidy was determined in the mononuclear cell population by using native cell smears and image cytometry...
- Local control of long bone giant cell tumour using curettage, burring and bone grafting without adjuvant therapyF Malek
San Francisco Department of Orthopaedic Surgery UCSF Comprehensive Cancer Center Orthopaedic Oncology Service, University of California, San Francisco, CA 94115 1939, USA
Int Orthop 30:495-8. 2006..In cases where more resources are available, the addition of adjuvant therapies, as noted in the recent literature, may be beneficial. The results of this study should be considered when designing multicenteric studies in the future...
- Effectiveness of intravenous bisphosphonate in treatment of giant cell tumor: a case report and review of the literatureOlarn Arpornchayanon
Department of Orthopedics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
J Med Assoc Thai 91:1609-12. 2008..The patient's gait was normal. From the present study, the authors demonstrate the effectiveness of zoledronate for treatment of giant cell tumor at the sacrum. It can reduce the morbidity from major surgery...
- Multicentric giant cell tumor of bone. Clinicopathologic analysis of thirty casesBenjamin Hoch
Mayo Clinic, Rochester, MN 55905, USA
J Bone Joint Surg Am 88:1998-2008. 2006b>Giant cell tumor of bone accounts for 4% to 5% of primary bone tumors. Approximately 1% of cases present as multiple synchronous or metachronous lesions...
- Treatment of local recurrences of giant cell tumour in long bones after curettage and cementing. A Scandinavian Sarcoma Group studyF Vult von Steyern
Department of Orthopaedics, Lund University Hospital, SE 221 85 Lund, Sweden
J Bone Joint Surg Br 88:531-5. 2006....
- [Giant cell tumor of bone. An evaluation of 87 patients]P U Tunn
Klinik fur Chirurgie und Chirurgische Onkologie, Charite Universitatsmedizin Berlin
Z Orthop Ihre Grenzgeb 141:690-8. 2003..Giant cell tumor (GCT) of bone is a very peculiar and interesting tumor due to of its biological behavior and the phenomenon of pulmonary metastases of a histologically benign tumor. We present the results of a retrospective study...
- Aneurysmal bone cyst and giant cell tumor of bone of the hand and distal radiusEdward A Athanasian
Hospital for Special Surgery, 535 East 70th Street, New York, New York 10021, USA
Hand Clin 20:269-81, vi. 2004Aneurysmal bone cyst and giant cell tumor of bone have historically been considered benign lesions that can behave in locally aggressive fashion. The clinical and pathologic findings share some common characteristics...
- Malignancy in giant cell tumor of boneFranco Bertoni
Istituto Ortopedico Rizzoli, Bologna, Italy
Cancer 97:2520-9. 2003..The goals of the current study were to define the clinicopathologic and histologic features of malignancy in giant cell tumors and to clarify the terminology...
- Complications associated with bone cementing for the treatment of giant cell tumors of boneTakuro Wada
Department of Orthopaedic Surgery, Sapporo Medical University, South 1, West 16, Sapporo 060 8543, Japan
J Orthop Sci 7:194-8. 2002..Acrylic cement reconstruction is a safe and effective procedure that provides local adjuvant therapy. Giant cell tumors with an associated intraarticular fracture remain a challenging problem to treat...
- Thapsigargin potentiates TRAIL-induced apoptosis in giant cell tumor of boneLin Huang
Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, N T, Hongkong SAR, China
Bone 34:971-81. 2004..In this study, we examined the potentiation of TRAIL-induced apoptosis in the stromal-like tumor cells of giant cell tumor of bone (GCT)...
- Expression of VEGF and MMP-9 in giant cell tumor of bone and other osteolytic lesionsS M Kumta
Department of Orthopaedics and Traumatology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N T Hongkong, China
Life Sci 73:1427-36. 2003..the expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in giant cell tumor of bone (GCT) and other osteolytic lesions in bone...
- Multicentric giant cell tumor of bone: ten lesions at presentationIl Hyung Park
Department of Orthopaedic Surgery, Kyungpook National University Hospital, 50 Samduk, Chung gu, 700 721 Taegu, Korea South
Skeletal Radiol 32:526-9. 2003The case of a 19-year-old man with multicentric and subsequent metachronous giant cell tumor of bone is presented. Ten lesions were identified at presentation and eventually two more lesions developed...
- Giant-cell tumour of bone. The long-term results of treatment by curettage and bone graftW Zhen
Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xian City, Shannxi, China
J Bone Joint Surg Br 86:212-6. 2004..Three had moderate function, and three needed amputation. Our findings indicate that treatment with an aqueous solution of zinc chloride and reconstructive bone grafting after curettage gives good results...
- De novo malignant transformation of giant cell tumor of boneT Marui
Department of Orthopaedic Surgery, Kobe University School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
Skeletal Radiol 30:104-8. 2001..In both patients, radiation and never been given. Malignant transformation has rarely been reported in patients with GCT of bone who have not received radiation treatment...
- Cytogenetic-morphologic correlations in aneurysmal bone cyst, giant cell tumor of bone and combined lesions. A report from the CHAMP study groupR Sciot
Department of Pathology, University of Leuven, Belgium
Mod Pathol 13:1206-10. 2000Aneurysmal bone cyst and giant cell tumor of bone are relatively rare bone tumors that sometimes coexist. We examined the karyotypes of 3 aneurysmal bone cysts, 12 giant cell tumors, and 3 combined lesions...
- Megavoltage radiation therapy for axial and inoperable giant-cell tumor of boneA Chakravarti
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
J Bone Joint Surg Am 81:1566-73. 1999..We performed the present study to evaluate the efficacy of megavoltage radiation in terms of lack of tumor progression and treatment-related morbidity...
- Giant cell tumor of bone: a clinicopathologic study of prognostic factorsF Masui
Department of Pathology, Jikei University School of Medicine, Tokyo, Japan
Pathol Int 48:723-9. 1998Forty-seven cases of giant cell tumor of bone were clinicopathologically reviewed to determine any useful prognostic factors. Disease recurred in 11 cases...
- Radiotherapy in the management of giant cell tumor of boneJimmy J Caudell
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 57:158-65. 2003To evaluate the outcomes of patients with giant cell tumor of bone (GCTB) treated with radiotherapy (RT) with or without surgical resection.
- Giant cell tumor of bone: an immunohistochemical comparative studyF Masui
Department of Pathology, Jikei University School of Medicine, Tokyo, Japan
Pathol Int 48:355-61. 1998....
- Cytochemical and ultrastructural changes in the osteoclast-like giant cells of giant cell tumor of bone following bisphosphonate administrationYuen Y Cheng
Department of Orthopaedics and Traumatology, Chinese University of Hong Kong, Hong Kong, China
Ultrastruct Pathol 27:385-91. 2003b>Giant cell tumor of bone (GCT) is a local aggressive neoplasm of bone characterized by expansive osteolytic lesions at the epiphysis of long bones...
- Long-term follow-up of patients with giant cell tumor of the sacrum treated with selective arterial embolizationPatrick P Lin
Section of Orthopaedic Oncology, M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 95:1317-25. 2002..The goal of this study is to evaluate the long-term outcome of selective arterial embolization as an alternative treatment modality...
- Osteoclast-type giant cell neoplasm of salivary gland. A microdissection-based comparative genotyping assay and literature review: extraskeletal "giant cell tumor of bone" or osteoclast-type giant cell "carcinoma"?Loretta L Y Tse
Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong, China
Am J Surg Pathol 28:953-61. 2004Primary salivary gland tumors resembling giant cell tumor of bone are very rare and have unsettled histogenesis. Both mesenchymal and epithelial origins have been suggested...
- Recurrent giant cell tumor of bone with simultaneous regional lymph node and pulmonary metastasesSajid S Qureshi
Department of Bone and Soft Tissue, Tata Memorial Hospital, E Borges Road, Parel, Bombay, India
Skeletal Radiol 34:225-8. 2005..In this case report we document a case of giant cell tumor of the patella in which, associated with local recurrence, there were simultaneous metastases to lymph nodes and lungs...
- Vascularized fibular graft after excision of giant-cell tumor of the distal radius: wrist arthroplasty versus partial wrist arthrodesisAkio Minami
Department of Orthopaedic Surgery, Hokkaido University School of Medicine, Kita 15, Nishi 7, Kita ku Sapporo, Hokkaido 060 8638, Japan
Plast Reconstr Surg 110:112-7. 2002....
- Reconstruction following en bloc resection of a giant cell tumor of the distal radius using a vascularized pedicle graft of the ulnaC S Intuwongse
Department of Orthopaedic Surgery, Institute of Orthopaedics, Lerd Sin General Hospital, Bangkok, Thailand
J Hand Surg Am 23:742-7. 1998..It provides early bone union and improves stability of the wrist joint. Four cases of giant cell tumor were treated and all 4 cases had satisfactory results...
- Molecular Mechanisms in Bone ResorptionSTEVEN LIETMAN; Fiscal Year: 2009..New information about mechanisms of bone resorption may facilitate the development of novel strategies to decrease bone resorption and may lead to new treatments for osteoporosis. ..
- RANK-Associated Inhibitor (RAIN) in Osteoclast FormationBryant Darnay; Fiscal Year: 2007..and have been implicated in various diseases, which include rheumatoid arthritis, osteoporosis, giant cell tumor of bone, Paget's disease, metastatic breast cancer, multiple myeloma, and familial expansile osteolysis...
- Bioengineering Annulus Fibrosus using Silk ScaffoldRita Kandel; Fiscal Year: 2006..The viability and mechanical properties of the tissue will be evaluated. ..
- Molecular Mechanisms of Ectopic Bone FormationSTEVEN LIETMAN; Fiscal Year: 2006..abstract_text> ..
- METABOLISM IN NORMAL AND OSTEOARTHRITIC CARTILAGEHenry Mankin; Fiscal Year: 1991..The receptors for this cytokine on normal and OA chondrocytes will be quantitated. Further definition of these cartilage metabolic pathways are of primary importance in our understanding of osteoarthritis...
- Minimally Invasive Approaches for Craniofacial SurgeryMaria Troulis; Fiscal Year: 2005..abstract_text> ..
- INVESTIGATING THE MECHANISMS OF PRB TUMOR SUPPRESSIONArnab Chakravarti; Fiscal Year: 2003..Specific Aim number 3: To determine whether the deregulation of E2F dependent transcription is correlated with the tumorigenic potential of RB -/- cells in-vivo. ..
- METABOLISM IN NORMAL AND OSTEOARTHRITIC CARTILAGEHenry Mankin; Fiscal Year: 2001..It is further speculated that the study of serine proteinases produced by OA cartilage may have strong implications for the management of this debilitating disease. ..
- Molecular Mechanisms in Bone ResorptionSteven A Lietman; Fiscal Year: 2010..New information about mechanisms of bone resorption may facilitate the development of novel strategies to decrease bone resorption and may lead to new treatments for osteoporosis. ..