alpha 1 antitrypsin deficiency

Summary

Summary: Deficiency of the protease inhibitor ALPHA 1-ANTITRYPSIN, leading primarily to degradation of elastin of the alveolar walls, as well as other structural proteins of a variety of tissues. (From Scriver, Beaudet, Sly, & Valle, The Metabolic and Molecular Bases of Inherited Disease, 7th ed, p4125)

Top Publications

  1. ncbi Alpha1-antitrypsin deficiency. 2: genetic aspects of alpha(1)-antitrypsin deficiency: phenotypes and genetic modifiers of emphysema risk
    D L DeMeo
    Channing Laboratory and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02446, USA
    Thorax 59:259-64. 2004
  2. ncbi Alpha-1 antitrypsin Null mutations and severity of emphysema
    Laura Fregonese
    Department of Pulmonology, Leiden University Medical Centre, Leiden, The Netherlands
    Respir Med 102:876-84. 2008
  3. ncbi Worldwide racial and ethnic distribution of alpha1-antitrypsin deficiency: summary of an analysis of published genetic epidemiologic surveys
    Frederick J de Serres
    Laboratory of Toxicology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27514 6716, USA
    Chest 122:1818-29. 2002
  4. ncbi Laboratory diagnosis of alpha1-antitrypsin deficiency
    Ilaria Ferrarotti
    Centro Diagnosi per il Deficit Ereditario di Alfa1 antitripsina, Clinica Malattie Apparato Respiratorio, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    Transl Res 150:267-74. 2007
  5. ncbi MEKC of desmosine and isodesmosine in urine of chronic destructive lung disease patients
    S Viglio
    Dipartimento di Biochemical, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Policlinico San Matteo, Università degli nStudi di Pavia
    Eur Respir J 15:1039-45. 2000
  6. ncbi Rate of progression of lung function impairment in alpha1-antitrypsin deficiency
    P A Dawkins
    Lung Investigation Unit, UniversityHospital Birmingham and University of Birmingham, Birmingham, UK
    Eur Respir J 33:1338-44. 2009
  7. ncbi Role of human neutrophil peptides in lung inflammation associated with alpha1-antitrypsin deficiency
    L Terry Spencer
    Division of Pulmonary Diseases, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL 32610 0296, USA
    Am J Physiol Lung Cell Mol Physiol 286:L514-20. 2004
  8. ncbi Alpha1-antitrypsin deficiency
    James K Stoller
    Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Lancet 365:2225-36. 2005
  9. ncbi Estimated numbers and prevalence of PI*S and PI*Z alleles of alpha1-antitrypsin deficiency in European countries
    I Blanco
    Div of Internal Medicine, Respiratory Diseases Branch, Hospital Valle del Nalon, 33920 Langreo, Principado de Asturias, Spain
    Eur Respir J 27:77-84. 2006
  10. ncbi Validation of computed tomographic lung densitometry for monitoring emphysema in alpha1-antitrypsin deficiency
    D G Parr
    Lung Investigation Unit, First Floor, Nuffield House, Queen Elizabeth Hospital, Birmingham B15 2TH, UK, and Department of Radiology, Leiden University Medical Centre, The Netherlands
    Thorax 61:485-90. 2006

Research Grants

  1. Phase 2 Study of rAAV1-CB-hAAT for Treatment of Alpha-1 Antitrypsin Deficiency
    Jeffrey D Chulay; Fiscal Year: 2010
  2. Preclinical & Phase I/II Trials of AAV-AAT Vectors
    Terence Flotte; Fiscal Year: 2005
  3. Rare Liver Disease Network
    Ronald Sokol; Fiscal Year: 2007
  4. Rare Lung Disease Clinical Research Network
    Bruce Trapnell; Fiscal Year: 2006
  5. NEWBORN SCREENING BY MULTIPLEX MOLECULAR ANALYSIS
    Edwin Naylor; Fiscal Year: 2002
  6. Liver regeneration with stems cells of uniparental origin
    Holger Willenbring; Fiscal Year: 2009
  7. Liver regeneration with stems cells of uniparental origin
    Holger Willenbring; Fiscal Year: 2010
  8. ABCA3 and the Response to Lung Injury
    RASHMIN SAVANI; Fiscal Year: 2009
  9. Genetic Modifiers of Alpha 1-Antitrypsin Deficiency
    Edwin Silverman; Fiscal Year: 2005
  10. APPROACHES TO THE GENETICS OF COPD
    Edwin Silverman; Fiscal Year: 2003

Detail Information

Publications227 found, 100 shown here

  1. ncbi Alpha1-antitrypsin deficiency. 2: genetic aspects of alpha(1)-antitrypsin deficiency: phenotypes and genetic modifiers of emphysema risk
    D L DeMeo
    Channing Laboratory and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02446, USA
    Thorax 59:259-64. 2004
    ..The role of modifying genetic factors which may interact with environmental factors (such as cigarette smoking) is discussed, and directions for future research are presented...
  2. ncbi Alpha-1 antitrypsin Null mutations and severity of emphysema
    Laura Fregonese
    Department of Pulmonology, Leiden University Medical Centre, Leiden, The Netherlands
    Respir Med 102:876-84. 2008
    ..Mutations causing total absence of serum AAT (Null mutations) were suggested to be associated with very early onset emphysema but their clinical phenotype is poorly known...
  3. ncbi Worldwide racial and ethnic distribution of alpha1-antitrypsin deficiency: summary of an analysis of published genetic epidemiologic surveys
    Frederick J de Serres
    Laboratory of Toxicology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27514 6716, USA
    Chest 122:1818-29. 2002
    ..There is a limited database of individuals affected by this disease worldwide. It has been estimated, for example, that there are 70,000 to 100,00 individuals affected in the United States, with comparable numbers in Europe...
  4. ncbi Laboratory diagnosis of alpha1-antitrypsin deficiency
    Ilaria Ferrarotti
    Centro Diagnosi per il Deficit Ereditario di Alfa1 antitripsina, Clinica Malattie Apparato Respiratorio, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Pavia, Italy
    Transl Res 150:267-74. 2007
    ..We also describe the diagnostic flowchart for AATD detection that we have developed accordingly...
  5. ncbi MEKC of desmosine and isodesmosine in urine of chronic destructive lung disease patients
    S Viglio
    Dipartimento di Biochemical, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Policlinico San Matteo, Università degli nStudi di Pavia
    Eur Respir J 15:1039-45. 2000
    ..Results obtained in subjects with alphal-antitrypsin deficiency suggest that this method might be used to evaluate the putative efficacy of replacement therapy...
  6. ncbi Rate of progression of lung function impairment in alpha1-antitrypsin deficiency
    P A Dawkins
    Lung Investigation Unit, UniversityHospital Birmingham and University of Birmingham, Birmingham, UK
    Eur Respir J 33:1338-44. 2009
    ..In PiZ alpha(1)-AT-deficient patients, FEV(1) decline was greatest in moderate disease, unlike K(CO) decline, which was greatest in severe disease. The FEV(1) decline showed associations with BDR, BMI, sex and exacerbation rate...
  7. ncbi Role of human neutrophil peptides in lung inflammation associated with alpha1-antitrypsin deficiency
    L Terry Spencer
    Division of Pulmonary Diseases, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL 32610 0296, USA
    Am J Physiol Lung Cell Mol Physiol 286:L514-20. 2004
    ..Importantly, the proinflammatory effects of HNP were blocked by alpha(1)-AT. HNP likely play an important role in amplifying and maintaining neutrophil-mediated inflammation in the lungs...
  8. ncbi Alpha1-antitrypsin deficiency
    James K Stoller
    Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Lancet 365:2225-36. 2005
    ..Evidence suggests that this approach is safe, slows the decline of lung function, could reduce infection rates, and might enhance survival. However, uncertainty about the cost-effectiveness of this expensive treatment remains...
  9. ncbi Estimated numbers and prevalence of PI*S and PI*Z alleles of alpha1-antitrypsin deficiency in European countries
    I Blanco
    Div of Internal Medicine, Respiratory Diseases Branch, Hospital Valle del Nalon, 33920 Langreo, Principado de Asturias, Spain
    Eur Respir J 27:77-84. 2006
    ..A remarkable lack in number of reliable epidemiological studies and marked differences among these European countries and regions within a given country was also found...
  10. ncbi Validation of computed tomographic lung densitometry for monitoring emphysema in alpha1-antitrypsin deficiency
    D G Parr
    Lung Investigation Unit, First Floor, Nuffield House, Queen Elizabeth Hospital, Birmingham B15 2TH, UK, and Department of Radiology, Leiden University Medical Centre, The Netherlands
    Thorax 61:485-90. 2006
    ..However, both methods are valid for use in longitudinal and interventional studies in which emphysema is the major outcome target...
  11. ncbi Exploring the role of CT densitometry: a randomised study of augmentation therapy in alpha1-antitrypsin deficiency
    A Dirksen
    Gentofte Hospital, Copenhagen University, Hellerup, Denmark
    Eur Respir J 33:1345-53. 2009
    ..In patients with alpha(1)-AT deficiency, CT is a more sensitive outcome measure of emphysema-modifying therapy than physiology and health status, and demonstrates a trend of treatment benefit from alpha(1)-AT augmentation...
  12. ncbi Heterozygous alpha-I antitrypsin deficiency as a co-factor in the development of chronic liver disease: a review
    K F Kok
    Department of Hepato Gastroenterology, Rijnstate Hospital, Arnhem, The Netherlands
    Neth J Med 65:160-6. 2007
    ..For the future, other interventions such as gene therapy or strategies to inhibit polymerisation are promising...
  13. ncbi Results of a case-detection programme for alpha1-antitrypsin deficiency in COPD patients
    C de la Roza
    Dept of Pneumology, Institut Clinic del Torax, Hospital Clinic, Red Respira, Barcelona 08036, Spain
    Eur Respir J 26:616-22. 2005
    ..Diagnostic yield and costs depend largely on inclusion criteria and the protocol for processing of samples...
  14. ncbi Alpha 1-antitrypsin deficiency associated with panniculitis
    S J Hendrick
    Department of Dermatology, University of Texas Medical Branch, Galveston 77550
    J Am Acad Dermatol 18:684-92. 1988
    ..The identification of the alpha 1-antitrypsin deficiency state as the cause of a distinct type of panniculitis adds additional evidence for the elimination of the term Weber-Christian disease...
  15. ncbi Short-term variability of biomarkers of proteinase activity in patients with emphysema associated with type Z alpha-1-antitrypsin deficiency
    Jan Stolk
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Respir Res 6:47. 2005
    ..Cross-sectional studies have shown increased levels of biomarkers of extracellular matrix degradation in vivo. Longitudinal variability of these biomarkers is unknown but desirable for clinical studies with proteinase inhibitors...
  16. ncbi Desmosine as a biomarker of elastin degradation in COPD: current status and future directions
    M Luisetti
    Laboratory of Biochemistry and Genetics, Institute of Respiratory Disease, IRCCS San Matteo Hospital Foundation, Pavia, Italy
    Eur Respir J 32:1146-57. 2008
    ....
  17. ncbi Alpha1-antitrypsin deficiency: a report from the 2nd meeting of the Alpha One International Registry, Rapallo (Genoa, Italy), 2001
    M Luisetti
    Dept of Respiratory Diseases, IRCCS San Matteo, Pavia, Italy
    Eur Respir J 20:1050-6. 2002
    ..In the framework of a rare and often under-recognised condition, this meeting is likely to be central to improving understanding and increasing awareness of alpha1-antitrypsin deficiency...
  18. ncbi The relationship of chronic sputum expectoration to physiologic, radiologic, and health status characteristics in alpha(1)-antitrypsin deficiency (PiZ)
    Lee J Dowson
    Lung Investigation Unit, Nuffield House, Queen Elizabeth University Hospital, Birmingham B15 2TH, UK
    Chest 122:1247-55. 2002
    ..This is reflected in an inferior health status, which is also influenced independently by an increased exacerbation frequency in those with CSE...
  19. ncbi Rapid screening for alpha1-antitrypsin deficiency in patients with chronic obstructive pulmonary disease using dried blood specimens
    Francisco Rodriguez
    Department of Biochemistry, Hospital Universitario Vall d'Hebron, Barcelona, Spain
    Am J Respir Crit Care Med 166:814-7. 2002
    ..This single-step, cost-effective technology is optimal for working with small amounts of DNA, as are present in DBS. The method is suitable for large-scale screening, in cases where PI type is important...
  20. ncbi Distribution of alpha-1 -antitrypsin phenotypes in Serbian newborns and children with liver disease
    A Topic
    Acta Paediatr 91:726-7. 2002
  21. ncbi Ongoing research in Europe: Alpha One International Registry (AIR) objectives and development
    R A Stockley
    Dept of Medicine, University Hospital Birmingham, Edgbaston, Birmingham, B15 2TH, UK
    Eur Respir J 29:582-6. 2007
    ..The success related to the convergence of national registries into a common database creating a unique registry beyond geographic boundaries and encompassing alpha1-antitrypsin deficiency from various ethnic groups...
  22. ncbi Sputum chemotactic activity in chronic obstructive pulmonary disease: effect of alpha(1)-antitrypsin deficiency and the role of leukotriene B(4) and interleukin 8
    I S Woolhouse
    Department of Medicine, Queen Elizabeth Hospital, Birmingham, UK
    Thorax 57:709-14. 2002
    ..Increased chemotactic activity, together with inhibitor deficiency, may contribute to the more rapid disease progression seen in alpha(1)-AT deficiency via increased neutrophil recruitment and release of neutrophil elastase...
  23. ncbi Biochemical efficacy and safety of a new pooled human plasma alpha(1)-antitrypsin, Respitin
    James K Stoller
    Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Chest 122:66-74. 2002
    ..Augmentation therapy with pooled human plasma-derived alpha(1)-antitrypsin (AAT) has been shown to have biochemical efficacy in restoring serum AAT levels above the protective threshold. Also, clinical efficacy has been suggested...
  24. ncbi Modification of gene expression and increase in alpha1-antitrypsin (alpha1-AT) secretion after homologous recombination in alpha1-AT-deficient monocytes
    Gillian L McNab
    Department of Respiratory Medicine, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Hum Gene Ther 18:1171-7. 2007
    ..The development of this methodology to repair the gene defect in hepatocytes should have beneficial effects on secretion, thereby protecting both the lung and liver...
  25. ncbi Asthma features in severe alpha1-antitrypsin deficiency: experience of the National Heart, Lung, and Blood Institute Registry
    Edward Eden
    James P Mara Center for Lung Disease, St Luke s Roosevelt Hospital Center, New York, NY 10019, USA
    Chest 123:765-71. 2003
    ..To describe asthma features in a cohort with alpha(1)-antitrypsin (AAT) deficiency, and determine the impact of asthma on FEV(1) decline...
  26. ncbi Prevalence and impact of bronchiectasis in alpha1-antitrypsin deficiency
    David G Parr
    Department of Respiratory Medicine, University Hospitals of Coventry and Warwickshire, Coventry CV2 2DX, UK
    Am J Respir Crit Care Med 176:1215-21. 2007
    ..alpha(1)-Antitrypsin (AAT) deficiency is associated with increased risk of chronic obstructive pulmonary disease (COPD), in particular emphysema, but airway disease is less well described...
  27. ncbi The effect of augmentation therapy on bronchial inflammation in alpha1-antitrypsin deficiency
    Robert A Stockley
    Department of Medicine, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom
    Am J Respir Crit Care Med 165:1494-8. 2002
    ..In summary, short-term therapy with AAT increased lung secretion concentrations and was associated with a fall in leukotriene B(4), which is thought to be central to the airway inflammation of AAT deficiency...
  28. ncbi IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency
    Dawn L DeMeo
    Brigham and Women s Hospital, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 38:114-20. 2008
    ..Haplotype analysis of IL10 SNPs suggested the strongest association with IL10 promoter SNPs. IL10 is likely an important modifier gene for the development of COPD in individuals with severe AAT deficiency...
  29. ncbi Outcome of bilateral lung volume reduction in patients with emphysema potentially eligible for lung transplantation
    B F Meyers
    Division of Cardiothoracic Surgery and the Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO, USA
    J Thorac Cardiovasc Surg 122:10-7. 2001
    ..The outcomes of these 99 patients are reviewed to assess the consequences of proceeding with lung volume reduction surgery on patients potentially eligible for lung transplantation...
  30. ncbi Linkage analysis of alpha 1-antitrypsin deficiency: lessons for complex diseases
    E K Silverman
    Channing Laboratory, Brigham and Women s Hospital, Boston, Mass 02114, USA
    Hum Hered 52:223-32. 2001
    ..We have used the protease inhibitor (PI) type as a genetic marker rather than a disease gene, and we have performed linkage analysis between PI type and serum A1AT level and spirometry-related phenotypes...
  31. ncbi Repeatability of lung density measurements with low-dose computed tomography in subjects with alpha-1-antitrypsin deficiency-associated emphysema
    J Stolk
    Department of Pulmonology C3 P, Leiden University Medical Center, Leiden, The Netherlands
    Invest Radiol 36:648-51. 2001
    ..The aim of the present study was to assess the intraindividual variation of lung densities measured by MSCT of patients with emphysema...
  32. ncbi Respiratory symptoms and lung function in 30-year-old individuals with alpha-1-antitrypsin deficiency
    Elisabeth Bernspång
    Department of Respiratory Medicine, Lund University, University Hospital, Malmo, Entrance 35, SE 205 02 Malmo, Sweden
    Respir Med 101:1971-6. 2007
    ..The aim of this study was to examine the prevalence of smoking, respiratory symptoms and lung function at the age of 30 in AAT-deficient individuals (PiZ and PiSZ) identified by neonatal screening...
  33. ncbi Thirteen-year experience in lung transplantation for emphysema
    Stephen D Cassivi
    Division of Cardiothoracic Surgery, Washington University Medical Center, St. Louis, Missouri 63110-1013, USA
    Ann Thorac Surg 74:1663-9; discussion 1669-70. 2002
    ..Bilateral lung transplantation for emphysema results in better long-term survival. Accumulated experience and modifications in perioperative care over our 13-year series may explain recently improved early and long-term survival...
  34. ncbi Prevalence and phenotype of subjects carrying rare variants in the Italian registry for alpha1-antitrypsin deficiency
    I Ferrarotti
    J Med Genet 42:282-7. 2005
  35. ncbi Health implications of alpha1-antitrypsin deficiency in Sub-Sahara African countries and their emigrants in Europe and the New World
    Frederick J de Serres
    National Institute of Environmental Health Sciences, Laboratory of Molecular Toxicology, Environmental Toxicology Program, Research Triangle Park, NC 27709 2233, USA
    Genet Med 7:175-84. 2005
    ..In addition, to discuss the unique susceptibility of these populations and emigrants to Europe and the New World to the adverse health effects associated with exposure to environmental microbes, chemicals, and particulates...
  36. ncbi Mortality in individuals with severe deficiency of alpha1-antitrypsin: findings from the National Heart, Lung, and Blood Institute Registry
    James K Stoller
    Department of Pulmonary, Allergy, and Critical Care Medicine, The Cleveland Clinic Foundation, 9500 Euclid Ave, A90, Cleveland, OH 44195, USA
    Chest 127:1196-204. 2005
    ..2 years)...
  37. ncbi The protease inhibitor PI*S allele and COPD: a meta-analysis
    M Dahl
    Dept of Clinical Biochemistry, Herlev University Hospital, Copenhagen, Denmark
    Eur Respir J 26:67-76. 2005
    ..In conclusion, the results show that the PI SZ genotype is a significant risk factor for chronic obstructive pulmonary disease. The risk of chronic obstructive pulmonary disease due to the PI MS genotype is not substantially elevated...
  38. ncbi Alpha 1-antitrypsin deficiency. 3: Clinical manifestations and natural history
    M Needham
    Department of Respiratory Medicine, Queen Elizabeth Hospital, Birmingham, UK
    Thorax 59:441-5. 2004
    ..A review of the clinical manifestations of alpha(1)-antitrypsin (AAT) deficiency, including lung disease and liver disease, and risk factors affecting the rate of decline in lung function in AAT deficient patients...
  39. ncbi A review of alpha-1 antitrypsin deficiency
    Justin Ranes
    Department of Pulmonary, Allergy, and Critical Care Medicine/A90, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Semin Respir Crit Care Med 26:154-66. 2005
    ....
  40. ncbi Trends in the diagnosis of symptomatic patients with alpha1-antitrypsin deficiency between 1968 and 2003
    Michael A Campos
    Division of Pulmonary and Critical Care Medicine, University of Miami School of Medicine, PO Box 016960 R 47, Miami, FL 33101, USA
    Chest 128:1179-86. 2005
    ..To support current guidelines recommending AATD testing of all individuals with COPD, we analyzed the diagnostic experience of a large cohort of symptomatic patients with AATD...
  41. ncbi Delay in diagnosis of alpha1-antitrypsin deficiency: a continuing problem
    James K Stoller
    Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic Foundation, A 90, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Chest 128:1989-94. 2005
    ..We also determined whether individuals living near medical centers with an expressed interest in AAT deficiency experienced shorter diagnostic delays than those living at a distance...
  42. ncbi Validation of a rapid, simple method to measure alpha1-antitrypsin in human dried blood spots
    Marina Gorrini
    Clin Chem 52:899-901. 2006
  43. ncbi Volume adjustment of lung density by computed tomography scans in patients with emphysema
    S B Shaker
    Department of Respiratory Medicine, Gentofte Hospital, Hellerup, Denmark
    Acta Radiol 45:417-23. 2004
    ..To determine how to adjust lung density measurements for the volume of the lung calculated from computed tomography (CT) scans in patients with emphysema...
  44. ncbi Alpha1-antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapy
    David A Lomas
    Respiratory Medicine Unit, Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Cambridge, United Kingdom
    J Clin Invest 110:1585-90. 2002
  45. ncbi Emphysema due to alpha-antitrypsin deficiency: familial study of the YBARCELONA variant
    Marc Miravitlles
    Department of Pneumology, Clinical Institute of Pneumology and Thoracic Surgery, Hospital Clinic IDIBAPS, Barcelona, Spain
    Chest 124:404-6. 2003
    ..The risk associated with this variant in its heterozygous form may be similar to that described for PiMZ...
  46. ncbi Lung volume reduction surgery in patients with emphysema and alpha-1 antitrypsin deficiency
    James K Stoller
    Division of Medicine, Section of Respiratory Therapy, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Ann Thorac Surg 83:241-51. 2007
    ..The role of lung volume reduction surgery (LVRS) for individuals with alpha-1 antitrypsin (AAT) deficiency is unclear...
  47. ncbi Correlation between annual change in health status and computer tomography derived lung density in subjects with alpha1-antitrypsin deficiency
    J Stolk
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands corrected
    Thorax 58:1027-30. 2003
    ..A study was undertaken to investigate prospectively the correlation between annual change in health status and computer tomography (CT) derived lung density in subjects with alpha(1)-antitrypsin deficiency...
  48. ncbi Alpha1-antitrypsin deficiency. 1: epidemiology of alpha1-antitrypsin deficiency
    M Luisetti
    Laboratorio di Biochimica e Genetica, Clinica Malattie Apparato Respiratorio, IRCCS Policlinico San Matteo, Universita di Pavia, Italy
    Thorax 59:164-9. 2004
    ..The protein and molecular characteristics of variants of the alpha1-antitrypsin (AAT) gene are described, and available data on the genetic epidemiology of AAT deficiency are presented...
  49. ncbi Alpha1-antitrypsin deficiency. 4: Molecular pathophysiology
    D A Lomas
    Respiratory Medicine Unit, Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 2XY, UK
    Thorax 59:529-35. 2004
    ..The current goals are to determine the cellular response to polymeric alpha(1)-antitrypsin and to develop therapeutic strategies to block polymerisation in vivo...
  50. ncbi Influence of calibration on densitometric studies of emphysema progression using computed tomography
    David G Parr
    Lung Investigation Unit, First Floor, Nuffield House, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    Am J Respir Crit Care Med 170:883-90. 2004
    ..Internal air calibration is therefore critical in longitudinal and multicenter lung densitometry studies of emphysema and incorporation of a correction factor is essential for quantitative image analysis...
  51. ncbi Alpha1-antitrypsin deficiency in 26-year-old subjects: lung, liver, and protease/protease inhibitor studies
    Eeva Piitulainen
    Department of Respiratory Medicine, Lund University, University Hospital, SE-20502 Malm, Sweden
    Chest 128:2076-81. 2005
    ..Analyses of SLPI and neutrophil lipocalin, a marker of neutrophil activity, indicate compensatory changes in the AAT-deficiency state...
  52. ncbi Molecular diagnosis of intermediate and severe alpha(1)-antitrypsin deficiency: MZ individuals with chronic obstructive pulmonary disease may have lower lung function than MM individuals
    M Dahl
    Department of Clinical Biochemistry, Herlev University Hospital, DK 2730 Herlev, Denmark
    Clin Chem 47:56-62. 2001
    ..We tested whether intermediate (MZ, SZ) and severe (ZZ) alpha(1)-antitrypsin deficiency affects lung function in the population at large...
  53. ncbi Formation and current results of a patient-organized registry for alpha(1)-antitrypsin deficiency
    J K Stoller
    Department of Pulmonary Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Chest 118:843-8. 2000
    ....
  54. ncbi Heteropolymerization of S, I, and Z alpha1-antitrypsin and liver cirrhosis
    R Mahadeva
    Respiratory Medicine Unit, Department of Medicine and Department of Haematology, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 2XY, United Kingdom
    J Clin Invest 103:999-1006. 1999
    ..Taken together, these results indicate that not only may mixed variants form heteropolymers, but that this can causally lead to the development of cirrhosis...
  55. ncbi Cholangiocarcinoma in two siblings with emphysema and alpha-1-antitrypsin deficiency
    D M Parham
    Department of Pathology, Ninewells Hospital and Medical School, Dundee
    Q J Med 71:359-67. 1989
    ..This lends support to the view that alpha-1-antitrypsin deficiency plays a role in the development of some primary liver tumours...
  56. ncbi Detection of emphysema progression in alpha 1-antitrypsin deficiency using CT densitometry; methodological advances
    David G Parr
    Department of Respiratory Medicine, University Hospitals of Coventry and Warwickshire, Clifford Bridge Road, Coventry, CV2 2DX, UK
    Respir Res 9:21. 2008
    ..However, emphysema is frequently localised to sub-regions of the lung and targeted densitometric sampling may be more informative than whole lung assessment...
  57. ncbi The alpha 1-antitrypsin gene and its deficiency states
    R G Crystal
    Trends Genet 5:411-7. 1989
    ....
  58. ncbi SERPINA1 gene variants in individuals from the general population with reduced alpha1-antitrypsin concentrations
    Michele Zorzetto
    Center for Diagnosis of Severe Alpha1 antitrypsin Deficiency, Laboratory of Biochemistry and Genetics, Institute for Respiratory Disease and Unit of Statistics and Biometry, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Italy
    Clin Chem 54:1331-8. 2008
    ..We decided to perform an exhaustive investigation of SERPINA1 gene variants in individuals from the general population with a moderately reduced serum AAT concentration, because such information is currently unavailable...
  59. ncbi Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis
    E K Silverman
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 157:1770-8. 1998
    ..The increased risk to relatives of early-onset COPD probands for reduced FEV1 and chronic bronchitis, limited to current or ex-smokers, suggests genetic risk factor(s) for COPD that are expressed in response to cigarette smoking...
  60. ncbi Lung function, smoking and survival in severe alpha 1-antitrypsin deficiency, PiZZ
    M C Wu
    National Heart, Lung and Blood Institute, Bethesda, MD 20892
    J Clin Epidemiol 41:1157-65. 1988
    ..The application of these results to the planning of studies on replacement therapy, smoking intervention strategy and longitudinal follow-up is discussed...
  61. ncbi Factors associated with advanced liver disease in adults with alpha1-antitrypsin deficiency
    Christopher L Bowlus
    Division of Gastroenterology, University of California at Davis, UC Davis Medical Center, 4150 V Street, PSSB 3500, Sacramento, CA 95817, USA
    Clin Gastroenterol Hepatol 3:390-6. 2005
    ..Our study aim was to characterize the liver disease in AAT and identify factors associated with advanced liver disease...
  62. ncbi Assessment of regional progression of pulmonary emphysema with CT densitometry
    M Els Bakker
    Division of Image Processing, Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Chest 134:931-7. 2008
    ..To test this hypothesis, a method was developed to assess emphysema severity at different levels in the lungs in order to estimate regional changes...
  63. ncbi Inherited chronic obstructive pulmonary disease: new selective-sequencing workup for alpha1-antitrypsin deficiency identifies 2 previously unidentified null alleles
    Janke Prins
    Department of Clinical Chemistry, Meander Medical Center, Utrechtseweg 160, Amersfoort, The Netherlands
    Clin Chem 54:101-7. 2008
    ..0 g/l...
  64. ncbi The role of chlamydia in the pathogenesis of pulmonary emphysema. Electron microscopy and immunofluorescence reveal corresponding findings as in atherosclerosis
    D Theegarten
    Department of Pathology, Ruhr University Bochum, Germany
    Virchows Arch 437:190-3. 2000
    ..Chronic infection and bacterial colonization associated with progressive disease seems to be relevant not only in atherosclerosis but also in pulmonary emphysema...
  65. ncbi High-resolution computed tomography scanning in alpha1-antitrypsin deficiency: relationship to lung function and health status
    L J Dowson
    Lung Investigation Unit, Queen Elizabeth Hospital, Birmingham, UK
    Eur Respir J 17:1097-104. 2001
    ....
  66. ncbi Matrix metalloprotease polymorphisms are associated with gas transfer in alpha 1 antitrypsin deficiency
    Christopher J McAloon
    Lung Investigation Unit, University Hospital Birmingham, Birmingham, UK
    Ther Adv Respir Dis 3:23-30. 2009
    ..Matrix metalloproteinases [MMPs] are believed to be important in the pathophysiology of COPD, and may therefore confer susceptibility to this phenotype in patients with AATD...
  67. ncbi Augmentation therapy reduces frequency of lung infections in antitrypsin deficiency: a new hypothesis with supporting data
    J Lieberman
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA, USA
    Chest 118:1480-5. 2000
    ..To propose an hypothesis that antiprotease augmentation therapy reduces the incidence of lung infections in alpha(1)-antitrypsin (AAT)-deficient patients, and to present supporting data...
  68. ncbi Chronic liver disease in heterozygous alpha1-antitrypsin deficiency PiZ
    H P Fischer
    Department of Pathology, University of Bonn, Germany
    J Hepatol 33:883-92. 2000
    ..We analyzed whether patients with this genetic defect carrying a single PiZ gene are at increased risk for developing chronic liver disease...
  69. ncbi Short-term supplementation therapy does not affect elastin degradation in severe alpha(1)-antitrypsin deficiency. The American-Italian AATD Study Group
    D J Gottlieb
    Department of Medicine, Boston University School of Medicine, MA 02118 2394, USA
    Am J Respir Crit Care Med 162:2069-72. 2000
    ..These findings raise the possibilities that protective levels of AAT in the lungs are insufficient or that elastin degradation in the lungs of these subjects is not dependent upon neutrophil elastase at this time...
  70. ncbi Screening for Alpha 1 antitrypsin deficiency in Tunisian subjects with obstructive lung disease: a feasibility report
    Sabri Denden
    Biochemistry and Molecular Biology Laboratory, Faculty of Pharmacy, AV Avicienne 1, 5019 Monastir, Tunisia
    Orphanet J Rare Dis 4:12. 2009
    ..We therefore planned a screening study for detection of AATD in patients with OLD in a cohort of patients from Kairouan in central Tunisia...
  71. ncbi Does the heterozygous state of alpha-1 antitrypsin deficiency have a role in chronic liver diseases? Interim results of a large case-control study
    Arie Regev
    Division of Hepatology, Center for Liver Diseases, University of Miami, Leonard M Miller School of Medicine, FL 33136, USA
    J Pediatr Gastroenterol Nutr 43:S30-5. 2006
    ..The role of the heterozygous PiZ state of alpha-1 antitrypsin deficiency (alpha1ATD) in the pathogenesis of chronic liver disease (LD) is still a matter of controversy...
  72. ncbi [Analysis of alpha-1-antitrypsin phenotypes and genotypes in patients with early-onset pulmonary emphysema]
    Szymon Dwomiczak

    Pneumonol Alergol Pol 73:12-7. 2005
    ....
  73. ncbi Association of moderate alpha-1 antitrypsin deficiency with lung cancer in the Serbian population
    Aleksandra S Topic
    Institute of Medical Biochemistry, Faculty of Pharmacy, Belgrade, Serbia and Montenegro
    Arch Med Res 37:866-70. 2006
    ....
  74. ncbi Homozygous deficiency of heparin cofactor II: relevance of P17 glutamate residue in serpins, relationship with conformational diseases, and role in thrombosis
    Javier Corral
    University of Murcia, Centro Regional de Hemodonación de Murcia, Murcia, Spain
    Circulation 110:1303-7. 2004
    ..Recent data obtained in mice lacking HCII suggest that this serpin might inhibit thrombosis in the arterial circulation. However, the clinical relevance and molecular mechanisms associated with deficiency of HCII in humans are unclear...
  75. ncbi Alpha-1 antitrypsin deficiency is not a rare disease but a disease that is rarely diagnosed
    Frederick J de Serres
    Laboratory of Molecular Toxicology, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 111:1851-4. 2003
    ..Such exposures are known to result in both lung and liver disease as well as other adverse health effects...
  76. ncbi [Role of genetic factors in the development of COPD]
    Masaharu Nishimura
    Division of Respiratory Medicine, Hokkaido University Graduate School of Medicine
    Nippon Rinsho 61:2095-100. 2003
    ..It is of note that the susceptibility to smoking could be explained also by non-genetic factors such as adenovirus latent infection to the airways...
  77. ncbi The TNFalpha gene relates to clinical phenotype in alpha-1-antitrypsin deficiency
    Alice M Wood
    Division of Medical Sciences, The Medical School, University of Birmingham, Birmingham, B15 2TT, UK
    Respir Res 9:52. 2008
    ..phenotypic variation in chronic obstructive pulmonary disease (COPD) in subjects with and without alpha 1 antitrypsin deficiency (AATD)...
  78. ncbi PI*S(iiyama), a deficiency gene of alpha 1-antitrypsin: evidence for the occurrence in western Japan
    I Yuasa
    Department of Legal Medicine, Tottori University School of Medicine, Yonago, Japan
    Jpn J Hum Genet 38:185-91. 1993
    ..Crossed immunoelectrophoresis after isoelectric focusing and agarose gel electrophoresis showed atypical banding patterns. PI*S(iiyama) is a rare deficiency gene, but it can occur sporadically all over the Japan...
  79. ncbi Alpha 1-antitrypsin: more than just deficiency
    R A Stockley
    Thorax 59:363-4. 2004
  80. ncbi Hereditary alpha-1-antitrypsin deficiency and its clinical consequences
    Laura Fregonese
    Alpha1 International Registry, c o Department of Pulmology, Leiden University Medical Center, Leiden, The Netherlands
    Orphanet J Rare Dis 3:16. 2008
    ..The end-stage liver and lung disease can be treated by organ transplantation. In AATD patients with cirrhosis, prognosis is generally grave...
  81. ncbi Alpha-1-antitrypsin deficiency (Siiyama) as indication for lung transplantation: proper timing for surgical intervention
    G Shindo
    Cardiothoracic Department, Meditopia Numazu Medical Clinic, Numazu City, Japan
    Minerva Chir 63:241-7. 2008
    ..Lung transplantation is one of the best reliable current therapies to improve quality of life of severely impaired patients...
  82. ncbi Respiratory disease in aggregate quarry workers related to risk factors and Pi phenotype
    Isabel Isidro Montes
    National Institute of Silicosis, Central Hospital of Asturias, 3306 Oviedo, Spain
    J Occup Environ Med 46:1150-7. 2004
    ..To evaluate the respiratory health and its relationship with exposure to silica, smoking, alpha 1-antitrypsin, and Pi phenotype in aggregate quarries workers...
  83. ncbi Deficient alpha-1-antitrypsin phenotypes and persistent airflow limitation in severe asthma
    Ilonka H van Veen
    Department of Pulmonology, C3P 18 Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Respir Med 100:1534-9. 2006
    ..We hypothesized that partial deficiency of AAT (non-PiM AAT phenotype) is a risk factor of persistent airflow limitation in asthma...
  84. ncbi Alpha1-antitrypsin deficiency: incidence and implications
    Roberta J Richmond
    Bellin College of Nursing
    Dimens Crit Care Nurs 24:255-60; quiz 261-2. 2005
    ..Critical care and advanced practice nurses will benefit from gaining a better understanding of the causes, pathophysiology, diagnosis, and treatment of this disorder...
  85. ncbi [Alpha 1-proteinase inhibitor deficiency and isolated liver cirrhosis without pulmonary emphysema in a 53-year-old female patient]
    S Stintzing
    Medizinische Klinik 1, Friedrich Alexander Universitat Erlangen Nurnberg, 91054 Erlangen
    Dtsch Med Wochenschr 130:2823-5. 2005
    ..She reported neither alcohol nor drug abuse and had no previous serious illness. She had smoked about 10 pack years of cigarettes in the past...
  86. ncbi Alpha-1-antitrypsin deficiency in children: liver disease is not reflected by low serum levels of alpha-1-antitrypsin - a study on 48 pediatric patients
    Thomas Lang
    Children s Hospital, Dr v Haunersches Kinderspital, University of Munich, Germany
    Eur J Med Res 10:509-14. 2005
    ..The aim of our study was to examine a correlation of total serum alpha1-AT, phenotype, and liver involvement in pediatric patients...
  87. ncbi Case detection of alpha1-antitrypsin deficiency: does it help the patient or the doctor?
    J Stolk
    Eur Respir J 26:561-2. 2005
  88. ncbi Alpha-1-antitrypsin deficiency asthma and allergy
    A G Palma Carlos
    Clinical Allergy Immunology Center CAIC, Lisbon, Portugal
    Eur Ann Allergy Clin Immunol 39:127-32. 2007
    ..The relationship between alpha-1-antitrypsin and asthma is discussed and general measures of treatment or prevention suggested...
  89. ncbi [Emphysema as a pulmonary manifestation of alpha-1 antitrypsin (alpha-1 AT) deficiency]
    Paweł Kuca
    Oddziału Intensywnej Terapii Pneumonologiczno Kardiologicznej, Instytut Gruźlicy i Chorób Płuc w Warszawie
    Pneumonol Alergol Pol 72:447-52. 2004
  90. ncbi [The variability of clinical presentation of chronic obstructive pulmonary disease in patients with hereditary alpha-1 antitrypsin deficiency]
    Paweł Kuca
    Oddziału Intensywnej Terapii Pneumonologiczno Kardiologicznej, Warszawa
    Pneumonol Alergol Pol 72:420-3. 2004
    ..In all patients tobacco smoking history, spirometric and 6-minutes walking tests as well as HRCT of the lung were performed and compared. The influence of smoking on the functional status is underlined...
  91. ncbi [Alpha1-proteinase inhibitor: structure and functions]
    Takahisa Imamura
    Division of Molecular Pathology, Kumamoto University Graduate School of Medical and Pharmaceutical Sciences
    Nippon Rinsho 63:81-7. 2005
  92. ncbi Structure and variation of human alpha 1-antitrypsin
    R W Carrell
    Nature 298:329-34. 1982
    ..The nature of the reactive centre helps explain why cigarette smoking greatly accelerates the onset and severity of this degenerative process to give the disease emphysema...
  93. ncbi Emphysema associated with complete absence of alpha 1- antitrypsin in serum and the homozygous inheritance [corrected] of a stop codon in an alpha 1-antitrypsin-coding exon
    K Satoh
    Pulmonary Branch, National Heart, Lung and Blood Institute, Bethesda, MD 20892
    Am J Hum Genet 42:77-83. 1988
    ..Although the consequences to the individual (i.e., emphysema) are identical to those associated with the common homozygous Z mutation, the homozygous null bellingham form of alpha 1AT deficiency has a very different genetic basis...
  94. ncbi The new genetics and chronic obstructive pulmonary disease
    Noor Kalsheker
    Division of Clinical Chemistry, Molecular Medical Sciences Institute of Genetics, Queens Medical Centre, University of Nottingham, Nottingham, UK
    COPD 5:257-64. 2008
    ....
  95. ncbi Emphysema in alpha1-antitrypsin deficiency: does replacement therapy affect outcome?
    Raja T Abboud
    Respiratory Division, University of British Columbia, 2775 Heather Street, Vancouver, V5Z 3J5, British Columbia, Canada
    Treat Respir Med 4:1-8. 2005
    ....
  96. ncbi Alpha-1-antitrypsin replacement therapy: current status
    Hatem Abusriwil
    Lung Investigation Unit, Nuffield House, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Birmingham, UK
    Curr Opin Pulm Med 12:125-31. 2006
    ..Recent advances in the understanding of the molecular pathology provide opportunities for development of new therapeutic targets for this genetic disorder...
  97. ncbi Alpha1-antitrypsin deficiency: biological answers to clinical questions
    R J Coakley
    Pulmonary Division, Beaumont Hospital, Dublin, Ireland
    Am J Med Sci 321:33-41. 2001
    ....
  98. ncbi Isoelectric focusing phenotyping and denaturing gradient gel electrophoresis genotyping: a comparison of two methods in detection of alpha-1-antitrypsin variants
    Mila Ljujic
    Institute of Molecular Genetics and Genetic Engineering, Belgrade, Serbia
    Transl Res 151:255-9. 2008
    ..Therefore, the optimal strategy for diagnostics of AAT deficiency should encompass detection of the most common AAT variants by IEF and screening for the less common variants by DGGE in combination with sequencing...
  99. ncbi Alpha-1 antitrypsin: now available, but do we need it?
    Erich W Russi
    Pulmonary Division, Department of Internal Medicine, University Hospital, Zurich, Switzerland
    Swiss Med Wkly 138:191-6. 2008
    ....
  100. ncbi Pathogenesis of COPD. Part I. The role of protease-antiprotease imbalance in emphysema
    R T Abboud
    Division of Respiratory Medicine, Department of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Int J Tuberc Lung Dis 12:361-7. 2008
    ....
  101. ncbi Augmentation therapy in alpha-1 antitrypsin deficiency
    Gustavo A Heresi
    Respiratory Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Expert Opin Biol Ther 8:515-26. 2008
    ..Alpha-1 antitrypsin deficiency is a genetic disorder that leads to early-onset emphysema. Recently, exogenous supplementation of the enzyme has become a therapeutic alternative...

Research Grants85

  1. Phase 2 Study of rAAV1-CB-hAAT for Treatment of Alpha-1 Antitrypsin Deficiency
    Jeffrey D Chulay; Fiscal Year: 2010
    ..Results from this Phase 2 trial will be used to develop a Phase 3 study designed to satisfy the requirements for licensure of a gene therapy treatment for this orphan disease. ..
  2. Preclinical & Phase I/II Trials of AAV-AAT Vectors
    Terence Flotte; Fiscal Year: 2005
    ..It is hoped that the combined data from these two studies will provide important dose-ranging information for all human uses of rAAV vectors by the IM route. ..
  3. Rare Liver Disease Network
    Ronald Sokol; Fiscal Year: 2007
    ..The RLDN will be a full partner in the Rare Diseases Clinical Research Network and will participate collaboratively with the other Clinical Research Centers and the Data and Technology Coordinating Center. ..
  4. Rare Lung Disease Clinical Research Network
    Bruce Trapnell; Fiscal Year: 2006
    ..Ongoing clinical, basic and translational studies at the centers chosen have already yielded critical insights into molecular mechanisms underlying lung function and defense in health and disease. ..
  5. NEWBORN SCREENING BY MULTIPLEX MOLECULAR ANALYSIS
    Edwin Naylor; Fiscal Year: 2002
    ..The assay expands the number of disorders detected by newborn screening thus providing an improved public health service. PROPOSED COMMERCIAL APPLICATION: Not Available ..
  6. Liver regeneration with stems cells of uniparental origin
    Holger Willenbring; Fiscal Year: 2009
    ..These embryonic stem cells would be derived from the respective patient's sperm or oocytes, and thus limit rejection problems associated with the use of existing embryonic stem cell lines. ..
  7. Liver regeneration with stems cells of uniparental origin
    Holger Willenbring; Fiscal Year: 2010
    ..These embryonic stem cells would be derived from the respective patient's sperm or oocytes, and thus limit rejection problems associated with the use of existing embryonic stem cell lines. ..
  8. ABCA3 and the Response to Lung Injury
    RASHMIN SAVANI; Fiscal Year: 2009
    ..Further, the findings emanating from these studies will be relevant to other severe conditions of the lung (e.g. cystic fibrosis) and liver (e.g. alpha-1-antitrypsin deficiency) that have similar mechanisms of disease. ..
  9. Genetic Modifiers of Alpha 1-Antitrypsin Deficiency
    Edwin Silverman; Fiscal Year: 2005
    ....
  10. APPROACHES TO THE GENETICS OF COPD
    Edwin Silverman; Fiscal Year: 2003
    ..abstract_text> ..
  11. Pulmonary Alveolar Proteinosis Research Conference
    Bruce Trapnell; Fiscal Year: 2005
    ..This conference will provide a forum where thought leaders focused on the molecular and cellular basis or clinical management of PAP will present cutting edge research, integrate concepts, and chart innovative research directions. ..
  12. RIBOZYMES AND RNA GENE THERAPIES FOR LIVER DISEASES
    Andrea Branch; Fiscal Year: 2003
    ..Northern analysis of RNAs extracted from serum samples of patients will establish the size distribution of HCV RNAs containing the terminal sequence. These studies will lead to new treatments for liver diseases. ..
  13. Environmental factors in alpha 1-antitrypsin deficiency
    Lee Newman; Fiscal Year: 2002
    ..Such research offers an opportunity to investigate environmental and genetic interactions in which the gene trait that confers susceptibility is known but in which the environmental triggers are not. ..
  14. The Molecular Basis of Serpin Function and Disfunction
    Patrick Wintrode; Fiscal Year: 2009
    ..Polymerization of alpha-1 antitrypsin is the underlying cause of these symptoms. Determining the structure of the polymerization prone intermediate is an important step in developing therapeutic agents. ..
  15. Genetic Determinants of COPD in Diverse Ethnic Groups
    Edwin Silverman; Fiscal Year: 2007
    ..The overall goal of this proposal is to test the hypothesis that shared genetic determinants influence the development of COPD in diverse ethnic groups. ..
  16. The Molecular Basis of Serpin Function and Disfunction
    Patrick Wintrode; Fiscal Year: 2009
    ..Polymerization of alpha-1 antitrypsin is the underlying cause of these symptoms. Determining the structure of the polymerization prone intermediate is an important step in developing therapeutic agents. ..
  17. AAT Deficiency & Liver Diseases Caused by Proteins
    Bruce Trapnell; Fiscal Year: 2006
    ....
  18. ABCA3 and the Response to Lung Injury
    Rashmin C Savani; Fiscal Year: 2010
    ..Further, the findings emanating from these studies will be relevant to other severe conditions of the lung (e.g. cystic fibrosis) and liver (e.g. alpha-1-antitrypsin deficiency) that have similar mechanisms of disease. ..