Summary: A pathological process resulting from the reaction of the body to external forces and abnormal conditions that tend to disturb the organism's homeostasis.

Top Publications

  1. ncbi Physiology and neurobiology of stress and adaptation: central role of the brain
    Bruce S McEwen
    Harold and Margaret Milliken Hatch, Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    Physiol Rev 87:873-904. 2007
  2. ncbi Stress, depression, and neuroplasticity: a convergence of mechanisms
    Christopher Pittenger
    Department of Psychiatry, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, CT 6508, USA
    Neuropsychopharmacology 33:88-109. 2008
  3. ncbi Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?
    Jyoti D Malhotra
    Howard Hughes Medical Institute and Departments of Biological Chemistry and Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Antioxid Redox Signal 9:2277-93. 2007
  4. ncbi Translational control in stress and apoptosis
    Martin Holcik
    Apoptosis Research Center, Room R3116, Children s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON, K1H 8L1, Canada
    Nat Rev Mol Cell Biol 6:318-27. 2005
  5. ncbi Stress, eating and the reward system
    Tanja C Adam
    University of California, San Francisco, Department of Psychiatry, United States
    Physiol Behav 91:449-58. 2007
  6. ncbi Behavioural and neurochemical effects induced by chronic mild stress applied to two different rat strains
    Stathis Bekris
    Department of Experimental Pharmacology, Medical School, University of Athens, M Asias 75, Goudi, 11527 Athens, Greece
    Behav Brain Res 161:45-59. 2005
  7. pmc Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins
    D Thomas Rutkowski
    Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    PLoS Biol 4:e374. 2006
  8. ncbi ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals
    Jingshi Shen
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Dev Cell 3:99-111. 2002
  9. ncbi Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS
    Paul Willner
    Department of Psychology, University of Wales Swansea, Swansea, UK
    Neuropsychobiology 52:90-110. 2005
  10. pmc Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response
    Phoebe D Lu
    Department of Cell Biology, School of Medicine, New York University, New York, NY 10016, USA
    J Cell Biol 167:27-33. 2004

Detail Information

Publications368 found, 100 shown here

  1. ncbi Physiology and neurobiology of stress and adaptation: central role of the brain
    Bruce S McEwen
    Harold and Margaret Milliken Hatch, Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    Physiol Rev 87:873-904. 2007
    The brain is the key organ of the response to stress because it determines what is threatening and, therefore, potentially stressful, as well as the physiological and behavioral responses which can be either adaptive or damaging...
  2. ncbi Stress, depression, and neuroplasticity: a convergence of mechanisms
    Christopher Pittenger
    Department of Psychiatry, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, CT 6508, USA
    Neuropsychopharmacology 33:88-109. 2008
    ..a fundamental mechanism of neuronal adaptation, is disrupted in mood disorders and in animal models of stress. Here we provide an overview of the evidence that chronic stress, which can precipitate or exacerbate depression, ..
  3. ncbi Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?
    Jyoti D Malhotra
    Howard Hughes Medical Institute and Departments of Biological Chemistry and Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Antioxid Redox Signal 9:2277-93. 2007
    ..It has also become apparent that activation of the UPR on exposure to oxidative stress is an adaptive mechanism to preserve cell function and survival...
  4. ncbi Translational control in stress and apoptosis
    Martin Holcik
    Apoptosis Research Center, Room R3116, Children s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON, K1H 8L1, Canada
    Nat Rev Mol Cell Biol 6:318-27. 2005
    Cells respond to stress stimuli through coordinated changes in gene expression. The regulation of translation is often used under these circumstances because it allows immediate and selective changes in protein levels...
  5. ncbi Stress, eating and the reward system
    Tanja C Adam
    University of California, San Francisco, Department of Psychiatry, United States
    Physiol Behav 91:449-58. 2007
    An increasing number of people report concerns about the amount of stress in their life. At the same time obesity is an escalating health problem worldwide...
  6. ncbi Behavioural and neurochemical effects induced by chronic mild stress applied to two different rat strains
    Stathis Bekris
    Department of Experimental Pharmacology, Medical School, University of Athens, M Asias 75, Goudi, 11527 Athens, Greece
    Behav Brain Res 161:45-59. 2005
    Chronic mild stress (CMS) has been reported to induce an anhedonic-like state in rats that resembles some of the symptoms of endogenous depression in humans...
  7. pmc Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins
    D Thomas Rutkowski
    Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    PLoS Biol 4:e374. 2006
    ..Here we describe the reconstitution of an adaptive ER stress response in a cell culture system...
  8. ncbi ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals
    Jingshi Shen
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Dev Cell 3:99-111. 2002
    ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecular chaperones...
  9. ncbi Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS
    Paul Willner
    Department of Psychology, University of Wales Swansea, Swansea, UK
    Neuropsychobiology 52:90-110. 2005
    The chronic mild stress (CMS) model of depression has high validity but has in the past been criticized for being difficult to replicate...
  10. pmc Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response
    Phoebe D Lu
    Department of Cell Biology, School of Medicine, New York University, New York, NY 10016, USA
    J Cell Biol 167:27-33. 2004
    b>Stress-induced eukaryotic translation initiation factor 2 (eIF2) alpha phosphorylation paradoxically increases translation of the metazoan activating transcription factor 4 (ATF4), activating the integrated stress response (ISR), a pro-..
  11. ncbi Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness
    James P Herman
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45267 0559, USA
    Front Neuroendocrinol 24:151-80. 2003
    Appropriate regulatory control of the hypothalamo-pituitary-adrenocortical stress axis is essential to health and survival...
  12. pmc Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis
    Vassiliki Karantza-Wadsworth
    Division of Medical Oncology, Department of Internal Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Genes Dev 21:1621-35. 2007
    ..Here we show that allelic loss of beclin1 and defective autophagy sensitized mammary epithelial cells to metabolic stress and accelerated lumen formation in mammary acini...
  13. ncbi Learning under stress: how does it work?
    Marian Joels
    SILS CNS, University of Amsterdam, The Netherlands
    Trends Cogn Sci 10:152-8. 2006
    The effects of stress on learning and memory are not always clear: both facilitating and impairing influences are described in the literature...
  14. ncbi Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress
    Constantine Tsigos
    Hellenic National Diabetes Center, Athens, Greece
    J Psychosom Res 53:865-71. 2002
    The stress system coordinates the adaptive responses of the organism to stressors of any kind.(1)...
  15. ncbi Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons
    Ajai Vyas
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India
    J Neurosci 22:6810-8. 2002
    The hippocampus and the amygdala are essential components of the neural circuitry mediating stress responses...
  16. ncbi Heat shock proteins: modifying factors in physiological stress responses and acquired thermotolerance
    Kevin C Kregel
    Integrative Physiology Laboratory, Department of Exercise Science, The University of Iowa, Iowa City 52242, USA
    J Appl Physiol (1985) 92:2177-86. 2002
    ..The precise functions of HSPs are unknown, but there is considerable evidence that these stress proteins are essential for survival at both normal and elevated temperatures...
  17. pmc Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents
    Tsuguhito Ota
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 118:316-32. 2008
    ER stress can cause hepatic insulin resistance and steatosis. Increased VLDL secretion could protect the liver from ER stress-induced steatosis, but the effect of lipid-induced ER stress on the secretion of VLDL is unknown...
  18. ncbi The stress system in the human brain in depression and neurodegeneration
    Dick F Swaab
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands
    Ageing Res Rev 4:141-94. 2005
    ..e., the final common pathway in the stress response...
  19. ncbi A transgenic mouse model for monitoring endoplasmic reticulum stress
    Takao Iwawaki
    Laboratory for Cell Recovery Mechanisms, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Nat Med 10:98-102. 2004
    Endoplasmic reticulum (ER) stress is caused by the accumulation of unfolded proteins in the ER lumen, and is associated with vascular and neurodegenerative diseases...
  20. ncbi Endocrinology of the stress response
    Evangelia Charmandari
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Physiol 67:259-84. 2005
    The stress response is subserved by the stress system, which is located both in the central nervous system and the periphery...
  21. pmc Endoplasmic reticulum stress in disease pathogenesis
    Jonathan H Lin
    Department of Biochemistry, University of California, San Francisco, CA 94143, USA
    Annu Rev Pathol 3:399-425. 2008
    ..This review provides background information on the unfolded protein response and discusses a selection of diseases whose pathogenesis involves ER stress.
  22. ncbi The unfolded protein response: a stress signaling pathway critical for health and disease
    Kezhong Zhang
    Department of Biological Chemistry, Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Neurology 66:S102-9. 2006
    ..deprivation, altered glycosylation, and overloading of cholesterol can disrupt ER homeostasis, impose stress to the ER, and subsequently lead to accumulation of unfolded or misfolded proteins in the ER lumen...
  23. ncbi The NPY system in stress, anxiety and depression
    Markus Heilig
    Division of Psychiatry, Neurotec Department, Karolinska Institute, Huddinge University Hospital M57, Stockholm 141 86, Sweden Laboratory of Clinical Science, NIAAA NIH, Bethesda, MD, USA
    Neuropeptides 38:213-24. 2004
    NPY antagonizes behavioral consequences of stress through actions within the brain...
  24. ncbi Roles of CHOP/GADD153 in endoplasmic reticulum stress
    S Oyadomari
    Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Cell Death Differ 11:381-9. 2004
    ..Perturbations of ER homeostasis affect protein folding and cause ER stress. ER can sense the stress and respond to it through translational attenuation, upregulation of the genes for ER ..
  25. pmc IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress
    Ja Wook Koo
    Department of Psychology, Yale University, New Haven, CT 06520 8205, USA
    Proc Natl Acad Sci U S A 105:751-6. 2008
    b>Stress decreases neurogenesis in the adult hippocampus, and blockade of this effect is required for the actions of antidepressants in behavioral models of depression...
  26. pmc Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice
    Nobuyuki Sudo
    Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Physiol 558:263-75. 2004
    ..the idea that such microbes may affect the development of neural systems that govern the endocrine response to stress, we investigated hypothalamic-pituitary-adrenal (HPA) reaction to stress by comparing germfree (GF), specific ..
  27. pmc MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14
    Ana Soloaga
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    EMBO J 22:2788-97. 2003
    Cells respond to mitogenic or stress stimuli by the rapid induction of immediate-early (IE) genes, which occurs concomitantly with the phosphorylation of histone H3 and the high-mobility-group protein HMG-14...
  28. pmc Endoplasmic reticulum stress: cell life and death decisions
    Chunyan Xu
    The Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Clin Invest 115:2656-64. 2005
    Disturbances in the normal functions of the ER lead to an evolutionarily conserved cell stress response, the unfolded protein response, which is aimed initially at compensating for damage but can eventually trigger cell death if ER ..
  29. ncbi Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life
    Ian C G Weaver
    Douglas Hospital Research Center, Montreal, Quebec H4H 1R3, Canada
    J Neurosci 25:11045-54. 2005
    b>Stress responses in the adult rat are programmed early in life by maternal care and associated with epigenomic marking of the hippocampal exon 1(7) glucocorticoid receptor (GR) promoter...
  30. ncbi Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons
    Daniel Saal
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Neuron 37:577-82. 2003
    ..that in vivo administration of drugs of abuse with different molecular mechanisms of action as well as acute stress both increase strength at excitatory synapses on midbrain dopamine neurons...
  31. pmc MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay
    Georg Stoecklin
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 23:1313-24. 2004
    b>Stress granules (SGs) are dynamic cytoplasmic foci at which stalled translation initiation complexes accumulate in cells subjected to environmental stress...
  32. ncbi Stress and the brain: from adaptation to disease
    E Ron de Kloet
    Department of Medical Pharmacology, Leiden Amsterdam Center for Drug Research and Leiden University Medical Center, Gorlaeus Laboratories, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands
    Nat Rev Neurosci 6:463-75. 2005
    In response to stress, the brain activates several neuropeptide-secreting systems...
  33. ncbi The prefrontal cortex as a key target of the maladaptive response to stress
    João J Cerqueira
    Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    J Neurosci 27:2781-7. 2007
    Research on the detrimental effects of stress in the brain has mainly focused on the hippocampus...
  34. ncbi Mitochondrial respiratory inhibition and oxidative stress elevate beta-secretase (BACE1) proteins and activity in vivo in the rat retina
    Kun Xiong
    Department of Anatomy, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
    Exp Brain Res 181:435-46. 2007
    Cerebral hypometabolism, oxidative stress and beta-amyloid peptide (Abeta) accumulation are key pathological events in Alzheimer's disease (AD). Beta-secretase (BACE, i.e...
  35. ncbi Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    Coleen T Murphy
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143 2200, USA
    Nature 424:277-83. 2003
    ..that the insulin/IGF-I pathway ultimately exerts its effect on lifespan by upregulating a wide variety of genes, including cellular stress-response, antimicrobial and metabolic genes, and by downregulating specific life-shortening genes.
  36. ncbi CRF and CRF receptors: role in stress responsivity and other behaviors
    Tracy L Bale
    Department of Animal Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6046, USA
    Annu Rev Pharmacol Toxicol 44:525-57. 2004
    ..evidence supporting an important role of this family in regulation of the endocrine and behavioral responses to stress. Although CRF appears to play a stimulatory role in stress responsivity through activation of CRFR1, specific ..
  37. ncbi Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease
    Margaret F Gregor
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    J Lipid Res 48:1905-14. 2007 challenged by many insults, including surplus energy, inflammation, insulin resistance, and considerable stress to various organelles...
  38. ncbi Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response
    Raphaelle Winsky-Sommerer
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 24:11439-48. 2004
    ..We tested whether the hypocretinergic system is a critical component of the stress response activated by the corticotropin-releasing factor (CRF)...
  39. ncbi Molecular and evolutionary basis of the cellular stress response
    Dietmar Kültz
    Physiological Genomics Group, Department of Animal Sciences, University of California, Davis, California 95616, USA
    Annu Rev Physiol 67:225-57. 2005
    The cellular stress response is a universal mechanism of extraordinary physiological/pathophysiological significance. It represents a defense reaction of cells to damage that environmental forces inflict on macromolecules...
  40. ncbi Prolonged endoplasmic reticulum stress in hypertrophic and failing heart after aortic constriction: possible contribution of endoplasmic reticulum stress to cardiac myocyte apoptosis
    Ken ichiro Okada
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Circulation 110:705-12. 2004
    ..The ER responds to stress by upregulating ER chaperones, but prolonged and/or excess ER stress leads to apoptosis...
  41. ncbi Stress hormones, proinflammatory and antiinflammatory cytokines, and autoimmunity
    Ilia J Elenkov
    Division of Rheumatology, Immunology and Allergy, Georgetown University Medical Center, Washington, DC 20007, USA
    Ann N Y Acad Sci 966:290-303. 2002
    Recent evidence indicates that glucocorticoids and catecholamines, the major stress hormones, inhibit the production of proinflammatory cytokines, such as interleukin (IL)-12, tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma, ..
  42. ncbi Overlapping distributions of orexin/hypocretin- and dopamine-beta-hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation, and stress
    Brian A Baldo
    Department of Psychiatry, University of Wisconsin Madison Medical School, 6001 Research Park Blvd, Madison, Wisconsin 53719, USA
    J Comp Neurol 464:220-37. 2003
  43. ncbi Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3
    Anna J Kim
    Department of Biochemistry, McMaster University, Hamilton, Ontario, L8S 4LB, Canada
    J Cell Sci 118:89-99. 2005
    ..the ability of the endoplasmic reticulum (ER) to fold proteins properly, resulting in the onset of ER dysfunction/stress. We and others have shown that ER stress can induce intracellular lipid accumulation through the activation of the ..
  44. ncbi Effects of caffeine, sleep loss, and stress on cognitive performance and mood during U.S. Navy SEAL training. Sea-Air-Land
    Harris R Lieberman
    Military Nutrition Division, U S Army Research Institute of Environmental Medicine, Natick, MA 01760 5007, USA
    Psychopharmacology (Berl) 164:250-61. 2002
    ..When humans are acutely exposed to multiple stressors, cognitive performance is substantially degraded. Few practical strategies are available to sustain performance under such conditions...
  45. pmc A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure
    Eva van Rooij
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 103:18255-60. 2006
    Diverse forms of injury and stress evoke a hypertrophic growth response in adult cardiac myocytes, which is characterized by an increase in cell size, enhanced protein synthesis, assembly of sarcomeres, and reactivation of fetal genes, ..
  46. pmc Inflammation, stress, and diabetes
    Kathryn E Wellen
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Clin Invest 115:1111-9. 2005
    ..We put forth for consideration some hypotheses regarding important unanswered questions in the field and suggest a model for the integration of inflammatory and metabolic pathways in metabolic disease...
  47. pmc Stress granules and processing bodies are dynamically linked sites of mRNP remodeling
    Nancy Kedersha
    Division of Rheumatology and Immunology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Cell Biol 169:871-84. 2005
    b>Stress granules (SGs) are cytoplasmic aggregates of stalled translational preinitiation complexes that accumulate during stress. GW bodies/processing bodies (PBs) are distinct cytoplasmic sites of mRNA degradation...
  48. ncbi p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage
    Joaquin M Espinosa
    Regulatory Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell 12:1015-27. 2003
    The tumor suppressor protein p53 regulates transcriptional programs that control the response to cellular stress. We show that distinct mechanisms exist to activate p53 target genes as revealed by marked differences in affinities and ..
  49. ncbi Evolution of the cellular stress proteome: from monophyletic origin to ubiquitous function
    Dietmar Kültz
    University of California, Davis, 1 Shields Avenue, Davis, CA 95616, USA
    J Exp Biol 206:3119-24. 2003
    Cells respond to acute environmental change by activating a stress response that is widely studied...
  50. ncbi Peritubular capillary dysfunction and renal tubular epithelial cell stress following lipopolysaccharide administration in mice
    Liping Wu
    Dept of Pharmacology and Toxicology, Univ of Arkansas for Medical Sciences, 4301 West Markham St, 611, Little Rock, AR 72205, USA
    Am J Physiol Renal Physiol 292:F261-8. 2007
    ..Using NAD(P)H autofluorescence as an indicator of cellular redox stress, we found that tubular cell stress was highly correlated with the percentage of dysfunctional capillaries (r(2) = ..
  51. ncbi Chronic stress alters dendritic morphology in rat medial prefrontal cortex
    Susan C Cook
    Department of Psychology, Indiana University, Bloomington, Indiana 47405, USA
    J Neurobiol 60:236-48. 2004
    Chronic stress produces deficits in cognition accompanied by alterations in neural chemistry and morphology. Medial prefrontal cortex is a target for glucocorticoids involved in the stress response...
  52. ncbi Critical role of mast cells in inflammatory diseases and the effect of acute stress
    Theoharis C Theoharides
    Department of Pharmacology and Experimental Therapeutics, Tufts New England Medical Center, Boston, MA, USA
    J Neuroimmunol 146:1-12. 2004
    ..indicate that they are also involved in a variety of neuroinflammatory diseases, especially those worsened by stress. In these cases, mast cells appear to be activated through their Fc receptors by immunoglobulins other than IgE, ..
  53. ncbi Stress and adult neurogenesis
    Christian Mirescu
    Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
    Hippocampus 16:233-8. 2006
    b>Stress hormones have potent growth-inhibiting effects on a variety of peripheral tissues. Consistent with this general function, stress has been shown to inhibit cell proliferation and, ultimately, neurogenesis in the hippocampus...
  54. pmc A mitochondrial specific stress response in mammalian cells
    Quan Zhao
    Department of Biochemistry, La Trobe University, Melbourne, Victoria 3086, Australia
    EMBO J 21:4411-9. 2002
    Cells respond to a wide variety of stresses through the transcriptional activation of genes that harbour stress elements within their promoters...
  55. pmc Autophagy is activated for cell survival after endoplasmic reticulum stress
    Maiko Ogata
    Division of Molecular and Cellular Biology, Department of Anatomy, Faculty of Medicine, University of Miyazaki, Kihara 5200, Kiyotake, Miyazaki 889 1692, Japan
    Mol Cell Biol 26:9220-31. 2006
    ..Here, we found that the autophagy system is activated as a novel signaling pathway in response to ER stress. Treatment of SK-N-SH neuroblastoma cells with ER stressors markedly induced the formation of autophagosomes, ..
  56. pmc Release of outer membrane vesicles by Gram-negative bacteria is a novel envelope stress response
    Amanda J McBroom
    Duke University Medical Center, Department of Biochemistry Box 3711, Durham, NC 27710, USA
    Mol Microbiol 63:545-58. 2007
    Conditions that impair protein folding in the Gram-negative bacterial envelope cause stress. The destabilizing effects of stress in this compartment are recognized and countered by a number of signal transduction mechanisms...
  57. ncbi ALIS are stress-induced protein storage compartments for substrates of the proteasome and autophagy
    Jason Szeto
    Infection, Immunity, Injury and Repair Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    Autophagy 2:189-99. 2006
    ..that are similar to DALIS, and not related to aggresomes, can be observed in several cell types in response to stress, including oxidative stress, transfection, and starvation...
  58. ncbi Optimization of chronic stress paradigms using anxiety- and depression-like behavioral parameters
    Kyoung Shim Kim
    Department of Neuroscience and Medical Research Institute, Ewha Womans University School of Medicine, Seoul, Republic of Korea
    J Neurosci Res 83:497-507. 2006
    Chronic stress is a risk factor for psychiatric illnesses, such as anxiety and depression disorders...
  59. ncbi Maternal stress alters endocrine function of the feto-placental unit in rats
    Jerome Mairesse
    Perinatal Stress Unit, Bat SN4 1, Univ of Lille 1, 59655 Villeneuve d Ascq, France
    Am J Physiol Endocrinol Metab 292:E1526-33. 2007
    Prenatal stress (PS) can cause early and long-term developmental effects resulting in part from altered maternal and/or fetal glucocorticoid exposure...
  60. ncbi Effects of chronic stress on hippocampal long-term potentiation
    Constantine Pavlides
    The Rockefeller University, New York, New York 10021, USA
    Hippocampus 12:245-57. 2002
    Chronic stress causes atrophy of the apical dendrites of CA3 pyramidal neurons and deficits in spatial memory...
  61. ncbi SC35 promotes sustainable stress-induced alternative splicing of neuronal acetylcholinesterase mRNA
    E Meshorer
    Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
    Mol Psychiatry 10:985-97. 2005
    ..splicing of neuronal acetylcholinesterase (AChE) pre-mRNA occurs during neuronal development and following stress, altering synaptic properties...
  62. pmc Decreased adrenocorticotropic hormone and cortisol responses to stress in healthy adults reporting significant childhood maltreatment
    Linda L Carpenter
    Mood Disorders Research Program, Butler Hospital, Brown Medical School, Providence, Rhode Island 02906, USA
    Biol Psychiatry 62:1080-7. 2007
    Preclinical research findings suggest that exposure to stress and concomitant hypothalamus-pituitary-adrenal (HPA) axis activation during early development can have permanent and potentially deleterious effects...
  63. ncbi Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis
    Masahiro Shuda
    Department of Microbiology and Cell Biology, The Tokyo Metropolitan Institute of Medical Science, 3 18 22 Honkomagome, Bunkyo ku, Tokyo 113 8613, Japan
    J Hepatol 38:605-14. 2003
    ..Thus, we investigated the regulatory mechanisms of the grp78 gene in liver malignancy...
  64. ncbi Repeated stress induces dendritic spine loss in the rat medial prefrontal cortex
    Jason J Radley
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cereb Cortex 16:313-20. 2006
    The prefrontal cortex (PFC) plays an important role in higher cognitive processes, and in the regulation of stress-induced hypothalamic-pituitary-adrenal (HPA) activity...
  65. pmc The RasGAP-associated endoribonuclease G3BP assembles stress granules
    Hélène Tourrière
    Institut de Genetique Moleculaire de Montpellier, UMR 5535 du CNRS, IFR 122, 1919 Route de Mende, 34293 Montpellier, Cedex 5, France
    J Cell Biol 160:823-31. 2003
    b>Stress granules (SGs) are formed in the cytoplasm in response to various toxic agents, and are believed to play a critical role in the regulation of mRNA metabolism during stress...
  66. ncbi Urban neighborhoods, chronic stress, gender and depression
    Flora I Matheson
    Centre for Research on Inner City Health, St Michael s Hospital, Toronto, Ontario, Canada
    Soc Sci Med 63:2604-16. 2006
    ..Factor analysis of census tract characteristics identified two measures of neighborhood chronic stress--residential mobility and material deprivation--and two measures of population structure--ethnic diversity and ..
  67. ncbi GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress
    Bernardo Yusta
    Department of Medicine, Banting and Best Diabetes Centre, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Cell Metab 4:391-406. 2006
    ..We show that a murine model of diabetes is associated with the development of ER stress in beta cells and that treatment with the GLP-1R agonist exendin-4 significantly reduced biochemical markers of ..
  68. ncbi Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction
    Mary Jeanne Kreek
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York, USA
    Nat Neurosci 8:1450-7. 2005
    ..may partially underlie complex personality and physiological traits--such as impulsivity, risk taking and stress responsivity--as well as a substantial proportion of vulnerability to addictive diseases...
  69. ncbi Interferon-gamma inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress
    Wensheng Lin
    Department of Neurology, Jack Miller Center for Peripheral Neuropathy, University of Chicago, Chicago, IL 60637, USA
    Brain 129:1306-18. 2006 cuprizone-treated mice the detrimental actions of IFN-gamma were associated with endoplasmic reticulum (ER) stress in remyelinating oligodendrocytes...
  70. ncbi Effects of chronic stress on dendritic arborization in the central and extended amygdala
    Ajai Vyas
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, UAS GKVK Campus, Bangalore 560065, India
    Brain Res 965:290-4. 2003
    A differential role has been suggested for two important areas in the neural circuitry of stress, central nucleus of the amygdala (CeA) and bed nucleus of stria terminalis (BNST) in the extended amygdala, in regulating fear versus anxiety...
  71. ncbi Differences between brain structures in nuclear translocation and DNA binding of the glucocorticoid receptor during stress and the circadian cycle
    Pierre Kitchener
    INSERM U588, Laboratoire de Physiopathologie du Comportement, Universite Bordeaux 2, Domaine de Carreire, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Eur J Neurosci 19:1837-46. 2004
    ..We analysed stress- and circadian-induced changes in nuclear translocation and GRE binding of GRs in the hippocampus and the ..
  72. pmc Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78
    Rammohan V Rao
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945 1400, USA
    FEBS Lett 514:122-8. 2002 Ca(2+) homeostasis and accumulation of unfolded proteins in the endoplasmic reticulum (ER) lead to an ER stress response. Prolonged ER stress may lead to cell death...
  73. ncbi A trip to the ER: coping with stress
    D Thomas Rutkowski
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI 48109 0650, USA
    Trends Cell Biol 14:20-8. 2004
    ..The UPR alleviates stress by upregulating protein folding and degradation pathways in the ER and inhibiting protein synthesis...
  74. ncbi The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage
    Claude F Burgoyne
    LSU Eye Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite B, New Orleans, LA 70112, USA
    Prog Retin Eye Res 24:39-73. 2005
    ..principles of biomechanical engineering are used to propose a central role for intraocular pressure (IOP)-related stress and strain in the physiology of ONH aging and the pathophysiology of glaucomatous damage...
  75. pmc Fetal programming of hypothalamo-pituitary-adrenal function: prenatal stress and glucocorticoids
    Amita Kapoor
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario, Canada
    J Physiol 572:31-44. 2006
    Prenatal stress (PS) and maternal exposure to exogenous glucocorticoids can lead to permanent modification of hypothalamo-pituitary-adrenal (HPA) function and stress-related behaviour...
  76. pmc Rapid loss of dendritic spines after stress involves derangement of spine dynamics by corticotropin-releasing hormone
    Yuncai Chen
    Departments of Pediatrics and Anatomy Neurobiology, University of California Irvine, Irvine, California 92697 4475, USA
    J Neurosci 28:2903-11. 2008
    Chronic stress causes dendritic regression and loss of dendritic spines in hippocampal neurons that is accompanied by deficits in synaptic plasticity and memory. However, the responsible mechanisms remain unresolved...
  77. ncbi Regulation of the selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress - SelS is a novel glucose-regulated protein
    Yuan Gao
    Metabolic Research Unit, School of Health Sciences, Deakin University, Pigdons Road, Waurn Ponds, VIC 3217, Australia
    FEBS Lett 563:185-90. 2004
    ..We have examined whether SelS is regulated by glucose deprivation and endoplasmic reticulum (ER) stress in HepG2 cells...
  78. ncbi Stress-induced premature senescence (SIPS)--influence of SIPS on radiotherapy
    Masatoshi Suzuki
    Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Radiat Res 49:105-12. 2008
    ..This process is known as stress-induced premature senescence (SIPS)...
  79. ncbi Apoptosis signal-regulating kinase 1 in stress and immune response
    Kohsuke Takeda
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Annu Rev Pharmacol Toxicol 48:199-225. 2008
    ..and Drosophila melanogaster have revealed that ASK1 is an evolutionarily conserved signaling intermediate in stress responses and appears to constitute a primitive but efficient defense system against stimuli harmful to organisms...
  80. ncbi Endoplasmic reticulum stress and the development of diabetes: a review
    Heather P Harding
    Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Diabetes 51:S455-61. 2002
    ..client proteins and they adapt to an imbalance between client protein load and folding capacity (so-called ER stress)...
  81. ncbi Socioeconomic status is associated with stress hormones
    Sheldon Cohen
    Department of Psychology, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213, USA
    Psychosom Med 68:414-20. 2006
  82. ncbi Exercise and the stress system
    George Mastorakos
    Endocrine Unit, Second Department of Obstetrics and Gynecology, Aretaieion Hospital, Athens, Greece
    Hormones (Athens) 4:73-89. 2005
    Exercise represents a physical stress that challenges homeostasis. In response to this stressor, autonomic nervous system and the hypothalamic-pituitary-adrenal axis are known to react and to participate in the maintenance of homeostasis...
  83. ncbi Inhibition of insulin amyloid formation by small stress molecules
    Anubhav Arora
    Department of Chemical and Materials Engineering, Arizona State University, Tempe, AZ 85287, USA
    FEBS Lett 564:121-5. 2004
    ..As a means of surviving against external stress, on the other hand, many microorganisms accumulate small stress molecules to prevent abnormal protein folding and ..
  84. pmc Role for activating transcription factor 3 in stress-induced beta-cell apoptosis
    Matthew G Hartman
    Department of Molecular and Cellular Biochemistry, Center for Molecular Neurobiology, Ohio State University, Columbus, USA
    Mol Cell Biol 24:5721-32. 2004
    Activating transcription factor 3 (ATF3) is a stress-inducible gene and encodes a member of the ATF/CREB family of transcription factors. However, the physiological significance of ATF3 induction by stress signals is not clear...
  85. pmc Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma
    Wensheng Lin
    Jack Miller Center for Peripheral Neuropathy, Department of Neurology, University of Chicago, Chicago, IL 60637, USA
    J Cell Biol 169:603-12. 2005
    ..apoptosis induced by IFN-gamma in cultured rat oligodendrocytes was associated with endoplasmic reticulum (ER) stress. ER stress also accompanied oligodendrocyte apoptosis and hypomyelination in transgenic mice that inappropriately ..
  86. ncbi Alterations in brain antioxidant status, protein oxidation and lipid peroxidation in response to different stress models
    Emel Sahin
    Department of Biochemistry, Faculty of Medicine, Akdeniz University, 07070 Antalya, Turkey
    Behav Brain Res 155:241-8. 2004
    The aim of this study was to investigate the effects of different stress models on copper, zinc-superoxide dismutase (Cu,Zn-SOD), catalase (CAT) and selenium-dependent glutathione peroxidase (Se-GSH-Px) activities, and reduced glutathione ..
  87. ncbi Expression of brain-derived neurotrophic factor and its receptors in the median eminence cells with sensitivity to stress
    Laurent Givalois
    Cerebral Plasticity Laboratory, Formation de Recherche en Evolution 2693 Centre National de la Recherche Scientifique, University of Montpellier II, Place Eugene Bataillon, 34095 Montpellier, France
    Endocrinology 145:4737-47. 2004
    ..T1 immunostaining was localized in all cellular types. Immobilization stress increased BDNF mRNA and BDNF immunoreactivity patterns and induced biphasic BDNF release from the ME, as analyzed ..
  88. ncbi Mitochondrial stress-induced calcium signaling, phenotypic changes and invasive behavior in human lung carcinoma A549 cells
    Govindasamy Amuthan
    Department of Animal Biology and Mari Lowe Center for Comparative Oncology School of Veterinary Medicine, University of Pennsylvania 3800 Spruce Street, Philadelphia, PA 19104 6047, USA
    Oncogene 21:7839-49. 2002
    We have investigated mechanisms of mitochondrial stress-induced phenotypic changes and cell invasion in tumorigenic but poorly invasive human pulmonary carcinoma A549 cells that were partly depleted of mitochondrial DNA (mtDNA)...
  89. ncbi Stress-induced anhedonia in mice is associated with deficits in forced swimming and exploration
    Tatyana Strekalova
    Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Neuropsychopharmacology 29:2007-17. 2004 develop a model for a depression-like syndrome in mice, we subjected male C57BL/6 mice to a 4-week-long chronic stress procedure, consisting of rat exposure, restraint stress, and tail suspension...
  90. pmc Emerging evidence indicates that physiologically relevant thermal stress regulates dendritic cell function
    Julie R Ostberg
    Department of Immunology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, 14263, USA
    Cancer Immunol Immunother 55:292-8. 2006
    ..In this review, we summarize what has been discovered about the role of mild thermal stress in regulating various Dendritic cell (DC) activities...
  91. ncbi Environmental enrichment reverses the effects of maternal separation on stress reactivity
    Darlene D Francis
    Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Montreal, Quebec H4H 1R3, Canada
    J Neurosci 22:7840-3. 2002
    ..factor (CRF) gene expression and hypothalamic-pituitary-adrenal (HPA) and behavioral responses to stress. We report here that environmental enrichment during the peripubertal period completely reverses the effects of ..
  92. ncbi Stress, visceral obesity, and metabolic complications
    Ioannis Kyrou
    Endocrinology, Metabolism and Diabetes Unit, Evgenidion Hospital, Athens University Medical School, Athens, 115 28, Greece
    Ann N Y Acad Sci 1083:77-110. 2006
    b>Stress is a state of threatened homeostasis or disharmony caused by intrinsic or extrinsic adverse forces and is counteracted by an intricate repertoire of physiologic and behavioral responses that aim to reestablish the challenged body ..
  93. ncbi Noise-induced stress response and hearing loss in goldfish (Carassius auratus)
    Michael E Smith
    Department of Biology and Center for Comparative and Evolutionary Biology of Hearing, University of Maryland, College Park, MD 20742, USA
    J Exp Biol 207:427-35. 2004
    ..We examined the short- and long-term effects of increased ambient sound on the stress and hearing of goldfish (Carassius auratus; a hearing specialist)...
  94. ncbi Induction of deltaFosB in reward-related brain structures after chronic stress
    Linda I Perrotti
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 24:10594-602. 2004
    Acute and chronic stress differentially regulate immediate-early gene (IEG) expression in the brain...
  95. ncbi Interplay of pathogens, cytokines and other stress signals in the regulation of dendritic cell function
    Juan Sabatte
    Institute of Haematological Research, National Academy of Medicine and National Reference Centre for AIDS, Department of Microbiology, Buenos Aires University School of Medicine, Buenos Aires, Argentina
    Cytokine Growth Factor Rev 18:5-17. 2007
    ..exerted by pathogen-associated molecular patterns (PAMPs), cytokines, chemokines, and other less characterized stress molecules on the activity of DCs...
  96. ncbi Stress integration after acute and chronic predator stress: differential activation of central stress circuitry and sensitization of the hypothalamo-pituitary-adrenocortical axis
    Helmer F Figueiredo
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    Endocrinology 144:5249-58. 2003
    ..In the current study, our group examined central and peripheral integration of stress responses in rats after acute or repeated exposure to a natural predator (cat)...
  97. ncbi Variations in the human pain stress experience mediated by ventral and dorsal basal ganglia dopamine activity
    David J Scott
    Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, The University of Michigan, Ann Arbor, Michigan 48109 0720, USA
    J Neurosci 26:10789-95. 2006
    ..encoding reward value, increasing evidence also implicates basal ganglia dopaminergic mechanisms in responses to stress and aversive stimuli...
  98. ncbi Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival
    Wen Xing Ding
    Departments of Pathology and Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    J Biol Chem 282:4702-10. 2007
    Autophagy is a cellular response to adverse environment and stress, but its significance in cell survival is not always clear...
  99. ncbi Stress-induced immune dysfunction: implications for health
    Ronald Glaser
    Department of Molecular Virology, Immunology and Medical Genetics, College of Medicine and Public Health and Institute for Behavioral Medical Research, Ohio State University, Columbus, OH 43210, USA
    Nat Rev Immunol 5:243-51. 2005
    ..PNI researchers have used animal and human models to learn how the immune system communicates bidirectionally with the central nervous and endocrine systems and how these interactions impact on health...
  100. ncbi Laboratory routines cause animal stress
    Jonathan P Balcombe
    Physicians Committee for Responsible Medicine, Washington, DC 20016, USA
    Contemp Top Lab Anim Sci 43:42-51. 2004
    Eighty published studies were appraised to document the potential stress associated with three routine laboratory procedures commonly performed on animals: handling, blood collection, and orogastric gavage...
  101. ncbi Differential effects of prenatal stress on the morphological maturation of hippocampal neurons
    A Fujioka
    Department of Emergency and Critical Care Medicine, Yamaguchi University School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Neuroscience 141:907-15. 2006
    The present study was designed to clarify an intensity-dependent effect of prenatal stress on the morphological development of hippocampal neurons in rats. In addition, the involvement of receptors for glucocorticoids, i.e...

Research Grants80

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  3. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  4. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  5. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..a combination of RS-Alpha-Lipoic Acid (LA) and L-Carnitine (ALCAR) will produce a measurable decline in oxidative stress in patients with thalassemia, 5) Increased platelet activation and hypercoagulability is the primary cause of the ..
  6. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013 the margins) Ischemia and reperfusion (I/R) injury results from an acute increase in oxidative/inflammatory stress during reperfusion after ischemia and triggers a cascade of pathophysiological events...
  7. Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit
    Robert A Harris; Fiscal Year: 2012
    ..FFAs), ketone bodies, triacylglcyerols (TAG), cholesterol, blood pH, and markers of inflammation and oxidative stress in mice fed a high saturated fat diet;(b) determine the molecular mechanisms responsible for the increases in ..
  8. Cardiovascular Responses to Sleep Apnea in Tetraplegia: A Pilot Study
    Jill M Wecht; Fiscal Year: 2010
    ..large negative intrathoracic pressure swings, and repetitive hypoxia/reoxygenation associated with oxidative stress and endothelial dysfunction have also been implicated...
  9. Correction of glutathione deficiency for treatment of diabetic nephropathy
    Paolo Fanti; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Oxidative stress and glutathione (GSH) imbalance are major contributors to the pathogenesis of diabetic nephropathy...
  10. Hypothalamic Orexin Role in Menopause-Associated Hot Flashes and Mood/Sleep Disru
    PHILIP LEE JOHNSON; Fiscal Year: 2013 hormones and behavior during my Masters with Thesis;2) neuroendocrinology and functional neuroanatomy of stress responses during my PhD dissertation;and 3) translational animal modeling during my postdoctoral training...
  11. Iron-mediated vascular disease in sickle cell disease.
    John C Wood; Fiscal Year: 2010
    ..Iron-mediated oxidative stress and increased levels of labile plasma iron (LPI), may worsen intravascular hemolysis and impair endothelial ..
  12. Brain mast cells and Chronic Fatigue Syndrome
    Theoharis C Theoharides; Fiscal Year: 2013
    ..Many CFS patients demonstrate abnormal hypothalamic-pituitary- adrenal (HPA) axis activity, while stress worsens symptoms...
  13. Enhanced iron removal with peptide linked chelators targeted to ferritin
    Elizabeth C Theil; Fiscal Year: 2010
    ..mineral is a cellular iron concentrate for protein synthesis and a scavenger of iron and oxidant during oxidant stress. Targeting iron chelators to ferritin itself should enhance iron removal during iron overload...
  14. Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?
    Qinghua Sun; Fiscal Year: 2013
    ..induces adipose dysfunction via reactive oxygen species (ROS)-dependent activation of endoplasmic reticulum (ER) stress and potentiation of insulin resistance. To achieve this goal, we first assess PM2...
  15. Multi-targeted Countermeasures against Acute and Delayed Effects of OP Exposure
    John A Butera; Fiscal Year: 2013
    ..the excitotoxic cascade of free-radical formation by preserving mitochondrial function and reducing oxidative stress and energetic crisis, and (2) the oxime-bearing fragment would salvage the OP-bound inactivated AChE and thereby ..
  16. FASEB SRC on Lysophospholipd Mediators in Health and Disease
    Julie D Saba; Fiscal Year: 2011
    ..LPA and S1P regulate chemotaxis, stress responses, cytoskeletal organization, calcium signaling, cell survival, apoptosis, autophagy, and gene ..
  17. Tyrosine Availability Influences Mesocortico-Limbic Catecholamines
    GEORGE EUGENE JASKIW; Fiscal Year: 2012
    ..These include post-traumatic stress disorder, traumatic brain injury, addictive disorders and Parkinson's Disease, all of which are ..
  18. A Hybrid PARP Inhibitor and Redox Catalyst for Lung Transplantation
    GARRY JOHN SOUTHAN; Fiscal Year: 2012 on R-503, allowing the molecule to shut down both PARP-dependent and PARP-independent pathways of redox stress. R-503 is a potent PARP inhibitor (IC50=20 nM), more cytoprotective than a monofunctional PARP inhibitor in vitro, ..
  19. Ang II and Aldosterone Effects on Insulin Resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..research has implicated a heightened renin-angiotensin-aldosterone system (RAAS) and associated enhanced oxidative stress in the pathogenesis and cardiovascular complications of insulin resistance in people with diabetes and ..
  20. Novel Mitochondrial Mechanisms of Ethanol-Induced Cardiac Injury in Aged Females
    DONNA HOPE KORZICK; Fiscal Year: 2010
    ..Of particular interest are adaptive changes in proteins associated with metabolism, oxidative stress, and cell death...
  21. CRF-Oxytocin Interaction in the Regulation of Stress and Affect
    Joanna Dabrowska; Fiscal Year: 2013
    According to the World Health Organization depression affects 121 million people worldwide. Chronic stress and thus increased corticotrophin releasing factor (CRF) signaling is indicated as a potential risk factor for depression...
  22. Regulation of thyroid hormone levels by central and peripheral pathways
    KRISTEN RACHEL VELLA; Fiscal Year: 2013
    ..Thus, acute regulation of TH levels during periods of nutritional stress or illness is an important adaptive mechanism for survival...
  23. Role of SAMe on UBC9 and sumolyation in liver cancer and alcoholic liver injury
    Maria Lauda Tomasi; Fiscal Year: 2012
    ..Genotoxic stress induces sumoylation of a broad number of proteins involved in nuclear function as well as proteins involved in ..
  24. Retinoid and Carotenoid Depletion in Patients at High-Risk for Liver Cancer
    Peter H Gann; Fiscal Year: 2010
    ..Oxidative stress due to chronic inflammation is a dominant force in the progression of chronic liver disease (CLD) and subsequent ..
  25. Pathogenesis and Treatment of Liver Disease in Transaldolase Deficiency
    Andras Perl; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Although oxidative stress is implicated in both acute acetaminophen-induced liver failure and chronic liver diseases, cirrhosis and hepatocellular carcinoma (HCC), no common underlying metabolic ..
  26. Soluble Epoxide Hydrolase as a Target for Ischemic Cardioprotection
    Donna M Van Winkle; Fiscal Year: 2012
    ..Given that a recent prospective study suggests an association between post-traumatic stress disorder and the development of coronary heart disease, and other data suggest that combat exposure results in ..
  27. Pituitary dysfunction, behavioral symptoms, and quality of life after blast mTBI
    CHARLES WILLIAM WILKINSON; Fiscal Year: 2012 associated with numerous non-specific symptoms easily mistaken for behavioral symptoms of posttraumatic stress disorder (PTSD) and chronic postconcussive syndrome, including fatigue, anxiety, depression, irritability, ..
  28. Role of Txnip in adapting fuel metabolism to nutritional state
    SIMON HUI; Fiscal Year: 2013
    ..In Aim 2, we will test the hypothesis that lower NADPH availability increases mitochondrial oxidative stress, thereby leads to impaired fuel oxidation...
  29. The influence of air pollution mixtures on biomarkers of airway oxidative stress
    Roby Greenwald; Fiscal Year: 2013
    ..oxidants, specifically, the influence of air pollution mixtures on markers of airway inflammation and oxidative stress. The training portion of this application will be critically important to achieve these goals...
    Enrique A Mesri; Fiscal Year: 2013
    ..effectors are molecules actively involved in KS viral oncogenesis, and suggest that Rac1 signaling and oxidative stress could be attractive KS chemopreventive and therapeutic targets...
  31. Regulation of ER stress-induced cell death
    Randal J Kaufman; Fiscal Year: 2013
    ..In pursuit of this goal, we have demonstrated that islets from Chop-/- mice are protected from oxidative stress that occurs upon accumulation of unfolded proteins in the ER...
  32. Sphingolipid Metabolism in Drosophila Development
    Julie D Saba; Fiscal Year: 2013
    ..signaling molecules involved in regulating mammalian development, immune function, inflammation and cellular stress responses...
  33. Right ventricular contractile dysfunction after pressure overload
    ..Rat RV papillary muscles subjected to contractile stress, modeling acute RV pressure overload, will be assessed for biochemical and histological evidence of protein ..
  34. Epigenetic mechanisms relevant to the pathogenesis of ALS
    Neil W Kowall; Fiscal Year: 2013
    ..this, the cause of motor neuron death is unknown and the role of mutant SOD1 in the generation of oxidative stress in ALS has not been established...
  35. Effect of PPARy Ligands on Alcohol-Induced Alveolar Macrophage Oxidative Stress
    Samantha M Yeligar; Fiscal Year: 2013
    ..Chronic alcohol ingestion increases Nox enzyme levels, leading to AM oxidative stress and dysfunction...
  36. Enterococcus faecalis, Colorectal Cancer, and Bystander Effects
    Mark M Huycke; Fiscal Year: 2012
    ..Among intestinal commensals E. faecalis is unique in generating extracellular superoxide, promoting oxidative stress, and damaging DNA...
  37. Behavioral Activation Therapy for Rural Veterans with Diabetes and Depression
    Aanand Dinkar Naik; Fiscal Year: 2013
    ..of interventions are well grounded and driven by relevant theoretical models including the transactional model of stress and coping, the Re-Aim framework to evaluate impact, and the 5 A's model for behavioral goal setting...
    Melanie H Cobb; Fiscal Year: 2012
    ..The Ste20 protein kinase oxidative stress responsive 1 (OSR1) and its homolog the serine, proline, alanine-rich kinase (SPAK) bind to WNK1 in cells, are ..
  39. DNA Damage and Response in the Bladder Microenvironment.
    Bradley P Dixon; Fiscal Year: 2013
    ..contribute to a hyperosmolal bladder microenvironment, and we have recently shown that this hyperosmolal stress disrupts gastrointestinal cell DNA damage signaling and repair...
    Gary Cecchini; Fiscal Year: 2013
    ..Third, as mitochondria are suggested to be involved in the stress response of cells, studies will be undertaken to investigate how acetylation affects the response in a cardiac ..
  41. Translational Machinery in Stress Signaling and Tumor Suppression
    THOMAS J contact BEGLEY; Fiscal Year: 2010
    ..In general, adaptation to stress promotes the repair of protein and DNA damage and must occur rapidly...
  42. Functional Genomics of the Mitochondrial Proteome
    Dennis R Winge; Fiscal Year: 2011
    ..dehydrogenase assembly factor (Sdh5) which we proved to be a disease gene for familial paraganglioma, Vms1 a novel stress-responsive system for mitochondrial protein quality control and Coa4 which are novel assembly factors for the ..
  43. Investigating Mechanism of Intracellular Rotational Transport with Optical T
    Jeffrey N Anker; Fiscal Year: 2012
    ..critical need to develop methods to evaluate their toxicity, especially at low concentrations that cause oxidative stress and adverse long-term health effects...
  44. Autonomic and Antihypertensive Actions of Neuronal CGRP/RAMP1 Receptors
    Mark W Chapleau; Fiscal Year: 2013
    ..nervous system CGRP/ RAMP1 receptors abrogates Ang-II induced dysautonomia and hypertension by reducing oxidative stress. Our preliminary data indicate that just a 1...
  45. Group A Streptococcus responses to oxidative stress
    Ioannis Gryllos; Fiscal Year: 2010
    ..To date, however, the GAS genes regulated in response to oxidative stress, including those regulated by PerR, have not been defined...
  46. Iron, Metabolic Regulation and Type 2 Diabetes Risk
    Donald A McClain; Fiscal Year: 2013
    ..2. Determine the consequences of the regulation of hepcidin by glucose on systemic iron balance and inflammatory stress. We show that the acute down regulation of hepcidin by glucose allows increased iron absorption, but the ..
  47. Insulin Signaling and the Heart in Diabetes
    EVAN DALE ABEL; Fiscal Year: 2011
    ..Multiple mechanisms such as lipotoxicity, glucotoxicity, oxidative stress, impaired myocardial calcium homeostasis and impaired insulin signaling have been implicated...
  48. Trichothecene Toxicity and the Ribotoxic Stress Response
    James J Pestka; Fiscal Year: 2012 exert toxicity by activating mitogen-activated protein kinases, the underlying mechanisms for this "ribotoxic stress response" (RSR) remain largely undefined...
  49. Physiology of Hypothalamic Neurosteroidal Progesterone
    Paul E Micevych; Fiscal Year: 2013
    ..Neurosteroids, steroids synthesized de novo in the brain, have been implicated in functions ranging from stress, depression, anxiety, to cognition...
  50. Collagen X and heparan sulfate proteoglycan in the hematopoietic stem cell niche.
    ELIZABETH G SWEENEY; Fiscal Year: 2012
    ..regulation of differentiation, growth hormones, respiration, cell cycle, cell death, spermatogenesis, obesity, stress, immunology, eye development, and dinosaur paleobiology...
  51. Mitochondrial Dysfunction and Adipose Insulin Resistance
    David A Bernlohr; Fiscal Year: 2013 applicant): A variety of animal, cell culture and molecular studies have correlated increased oxidative stress and the accumulation of reactive oxygen species (ROS) such as superoxide anion and hydroxyl radicals to type 2 ..
  52. Prostate cancer chemoprevention by penta-galloyl-glucose
    Junxuan Lu; Fiscal Year: 2013
    ..DNA replicative synthesis and the role in S-arrest and apoptosis with an emphasis on DNA damage/replicative stress-checkpoint pathways (e.g., ATM/ATR, p53). Aim 2...
  53. Hydrodynamic forces modulate renal tubular function
    Rajeev Rohatgi; Fiscal Year: 2012
    ..cells respond to hydrodynamic forces associated with increases in urine flow rate, such as laminar shear stress (LSS), with increases in intracellular Ca2+ concentration ([Ca2+]i) which are believed to be transduced by the ..
  54. Role and Regulation of INrf2
    ANIL KUMAR JAISWAL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): INrf2:Nrf2 acts as a sensor for oxidative/electrophilic stress. INrf2 functions as an adaptor that interacts with Nrf2 and brings closer to ubiquitin ligase Cul3-Rbx1 for ubiquitination and degrading ..
  55. Mechanism of Bladder Overactivity in Pelvic Ischemia
    Kazem M Azadzoi; Fiscal Year: 2013
    ..Oxidative stress in cultured smooth muscle cells upregulated redox survival signaling via PI3-kinase and Akt expression and evoked ..
  56. Mitochondrial dysfunction, oxidative stress, and surgical acute kidney injury
    ..period, the candidate will test the hypotheses that 1) Mitochondrial dysfunction is associated with oxidative stress during cardiac surgery and predicts AKI following cardiac surgery (Aim 1) and that 2) Treatment with a ..
  57. Vascular dysfunction and oxidative stress in primary amyloidosis
    RAYMOND QUEZON MIGRINO; Fiscal Year: 2010
    ..Biopsy studies and animal studies suggest that amyloid light chains cause oxidative stress leading to tissue damage or dysfunction in colon and cardiac tissues...
  58. Tat and CDK9 on gene expression alterations coupled to HIV-1 Associated Dementia
    Xavier Grana; Fiscal Year: 2010
    ..Our data also show that inhibition of CDK9 results in the upregulation of a subset of genes including stress and stimuli response genes (Gadd45A, Gadd45B, IL-8 and IL-12), as well as deregulation of a number of genes that ..
  59. Novel PET imaging agents for early diagnosis of plaque deposition in Alzheimer's
    Padmakar Kulkarni; Fiscal Year: 2010
    ..Experts in the field stress the importance of diagnosing the disease at an early stage, since patients would do better if they are identified ..
  60. Comparison of Diesel and Biodiesel Emissions and Health Effects in Underground Mi
    Jefferey L Burgess; Fiscal Year: 2013
    ..Inflammatory markers and markers of oxidative stress, including interleukin (IL)-6, -8 and -10, myeloperoxidase (MPO), and matrix metalloproteinase-9 (MMP-9) will be ..
  61. Neural mechanisms by which chronic stress regulates inflammation in asthma
    Melissa A Rosenkranz; Fiscal Year: 2013
    ..primary objectives of these projects are to (1) elucidate the neural circuitry through which chronic psychosocial stress influences the inflammatory response in asthma (2) quantify the impact of chronic stress on objective measures of ..
  62. Regulation of epithelial cell homeostasis by actin microfilaments
    Seema Khurana; Fiscal Year: 2010
    ..Apoptosis plays an important role in determining the architecture of intestinal epithelia and also a part of the stress response of intestinal epithelial cells to toxic stimuli...
  63. Monitoring cellular redox signaling and oxidant stress in vivo
    Paul T Schumacker; Fiscal Year: 2010
    ..High levels of ROS cause oxidative damage to proteins, lipids and DNA. Oxidant stress has been implicated in the cellular dysfunction associated with ischemia- reperfusion injury, vascular disease, ..
    Christina Chambers; Fiscal Year: 2011
    ..term consequences of a sub-optimum prenatal environment, including maternal chemical exposure, nutrition, and/or stress. Because of human-health concerns about the developmental toxicity of drugs and chemicals, scientists, physicians ..
  65. Androgen Modulation of Neurodegeneration in Dopamine Neurons
    Rebecca L Cunningham; Fiscal Year: 2010
    ..It is believed that the underlying mechanism of PD involves oxidative stress leading to cellular apoptosis...
  66. Safety signal learning in Rhesus monkeys following early life stressChallenge Ar
    MICHAEL NMN DAVIS; Fiscal Year: 2010
    ..The major hypothesis is that post-traumatic stress disorder (PTSD) leads to a reduction in the ability to respond to safety signals...
  67. Chronic stress mediates fat-related changes in insulin signaling and gut motility
    CHARALABOS contact POTHOULAKIS; Fiscal Year: 2010
    ..underlying these associations are unknown, accumulating evidence clearly demonstrates chronic psychological stress as a key risk factor in this cluster of diseases...
  68. Oxidative stress and neurogenetic networks in Drosophila
    Robert R H Anholt; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Oxidative stress resulting from chemical exposure has been implicated as a contributing risk factor for a range of neurodegenerative diseases...
  69. Role and Mechanisms of Prolactin on HPA Axis Activation Following Stress
    James Janik; Fiscal Year: 2009 that circulating prolactin (PRL) levels regulate the Hypothalamic- Pituitary-Adrenal (HPA) axis response to stress. Additionally, the mechanism of action of PRL on HPA axis activation occurs due to alterations in PRL transport ..
  70. Molecular Pathological Mechanism & Potential Therapeutics of Lafora Disease
    YAN NONE LIU; Fiscal Year: 2010
    ..are diverse abnormal aggregates formed inside or outside of affected neuronal cells and endoplasmic reticulum (ER) stress-induced neuronal apoptosis...
  71. Role of OFQ/N in Regulating the Prolactin Response to Stress
    Phyllis Callahan; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Stress affects virtually everyone in society at some point in life and it has major deleterious effects on health...
  72. Stress, Cellular Aging and Susceptibility to Infectious Disease
    Sheldon A Cohen; Fiscal Year: 2010
    ..Biomarker Discovery and Validation and specific challenge topic: 03-AT-101* Psychoneuroimmunology biomarkers of stress. Identification of biomarkers to assess the impact of stress, both social and biological, on immune function...
    BARBARA SNIDER; Fiscal Year: 1999
    ..The heat stress response is a highly conserved response to stress seen in organisms from bacteria to man...
    David Savitz; Fiscal Year: 2004
    Though physical exertion and stress have been considered in a number of previous studies of pregnancy outcome, their potential influence on preterm birth and reduced fetal growth remains unresolved...
  75. Race Related Stressors and Preterm Birth in African American Women
    Carmen Giurgescu; Fiscal Year: 2009
    ..These stressors increase stress and are related to higher rates of preterm birth...
  76. Modulation of cancer prevention by social stress
    Hildegard M Schuller; Fiscal Year: 2010
    ..Chronic psychological stress and the resulting systemic increase in stress neurotransmitters noradrenaline and adrenaline and the ..
  77. Role of Tumor and Stromal Cell Metabolism in Stress Adaptation and Progression
    EILEEN contact WHITE; Fiscal Year: 2010
    ..Deregulated tumor cell growth and altered metabolism are also a source of metabolic stress. Oxygen, nutrient and factor deprivation caused by growth to high density and insufficient angiogenesis, and ..
    Maureen Hatch; Fiscal Year: 1993
    ..requests monies to investigate menstrual function in women workers and to study effects of physical and mental job stress, and stress-related behaviors like caffeine consumption, on cycle characteristics and ovarian hormone patterns...
  79. mtDNA mutation/heteroplasmy: a sensitive functional biomarker of oxidative stress
    Bruce N Ames; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Many biomarkers are responsive to oxidative stress and modulating effects of antioxidant dietary supplements, but the disease relevance of these markers is uncertain because of the lack of known ..
  80. Stress regulation of the endocannabinoid system: Effects on synaptic physiology
    Christian Reich; Fiscal Year: 2009
    b>Stress-related disorders such as major depressive disorder and post-traumatic-stress are serious mental illnesses that affect over 20 million Americans...