gangrene

Summary

Summary: Death and putrefaction of tissue usually due to a loss of blood supply.

Top Publications

  1. ncbi Calciphylaxis in a patient with end-stage renal disease secondary to systemic lupus erythematosus associated with acral gangrene and mesenteric ischemia
    N Igaki
    Department of Internal Medicine, Takasago Municipal Hospital
    Intern Med 40:1232-7. 2001
  2. ncbi Limb gangrene following treatment of limb injury by traditional bone setter (Tbs): a report of 15 consecutive cases
    O E Nwankwo
    Department of Surgery, University of Nigeria Teaching Hospital, Enugu
    Niger Postgrad Med J 12:57-60. 2005
  3. ncbi [Upper extremity gangrene in an infant of a diabetic mother, presenting at birth]
    L Vakrilova
    Akush Ginekol (Sofiia) 44:51-4. 2005
  4. ncbi Endovascular repair of spontaneous infrarenal aortic dissection presenting as severe lower extremity ischaemia
    D J Adam
    University Department of Vascular Surgery, Heart of England NHS Foundation Trust, Birmingham, UK
    Eur J Vasc Endovasc Surg 34:699-701. 2007
  5. ncbi Successful treatment of diabetic gangrene with topical application of a mixture of peripheral blood mononuclear cells and basic fibroblast growth factor
    Jun Asai
    Department of Dermatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Japan
    J Dermatol 33:349-52. 2006
  6. doi Left paraduodenal hernia: a rare cause of large bowel obstruction and gangrene
    Abu Bakar Hafeez Bhatti
    Surgical Unit IV, Dow University of Health Sciences and Civil Hospital, Karachi
    J Coll Physicians Surg Pak 22:250-1. 2012
  7. ncbi Presentation and outcome of purpura fulminans associated with peripheral gangrene in 12 patients at Mayo Clinic
    Mark D P Davis
    Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Acad Dermatol 57:944-56. 2007
  8. ncbi Disseminated intravascular coagulation complicated by peripheral gangrene in a rhesus macaque (Macaca mulatta) experimentally infected with Plasmodium coatneyi
    Alberto Moreno
    Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    Am J Trop Med Hyg 76:648-54. 2007
  9. ncbi Peripheral gangrene complicating Salmonella typhi septicaemia in a Gambian infant
    B J Okoko
    Medical Research Council, Fajara, The Gambia, West Africa
    J Trop Pediatr 47:250-1. 2001
  10. ncbi Heat insoluble cryoglobulin associated with gangrene in multiple myeloma
    Amir Modarressi
    Department of Medicine, Division of Hematology, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
    J Clin Apher 18:190-3. 2003

Detail Information

Publications255 found, 100 shown here

  1. ncbi Calciphylaxis in a patient with end-stage renal disease secondary to systemic lupus erythematosus associated with acral gangrene and mesenteric ischemia
    N Igaki
    Department of Internal Medicine, Takasago Municipal Hospital
    Intern Med 40:1232-7. 2001
    ..calcific arteriolopathy to occur following which several factors including chronic administration of corticosteroids, photosensitivity in lupus, and significant weight loss may have contributed to acral gangrene and mesenteric ischemia.
  2. ncbi Limb gangrene following treatment of limb injury by traditional bone setter (Tbs): a report of 15 consecutive cases
    O E Nwankwo
    Department of Surgery, University of Nigeria Teaching Hospital, Enugu
    Niger Postgrad Med J 12:57-60. 2005
    This study is done to evaluate cases of limb gangrene resulting from treatment of limb injury by traditional bonesetter.
  3. ncbi [Upper extremity gangrene in an infant of a diabetic mother, presenting at birth]
    L Vakrilova
    Akush Ginekol (Sofiia) 44:51-4. 2005
    In utero gangrene of an extremity because of an arterial thrombosis is rare. More than 20% of the reported cases concern infants of diabetic mothers (IDM) with poor control of diabetes...
  4. ncbi Endovascular repair of spontaneous infrarenal aortic dissection presenting as severe lower extremity ischaemia
    D J Adam
    University Department of Vascular Surgery, Heart of England NHS Foundation Trust, Birmingham, UK
    Eur J Vasc Endovasc Surg 34:699-701. 2007
    ..The patient underwent digital amputation and debridement of the foot four weeks post-operatively. At 12 months follow-up, he remains symptom-free with an excluded dissection, patent reconstruction and healed foot...
  5. ncbi Successful treatment of diabetic gangrene with topical application of a mixture of peripheral blood mononuclear cells and basic fibroblast growth factor
    Jun Asai
    Department of Dermatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Japan
    J Dermatol 33:349-52. 2006
    Diabetic gangrene is a non-healing skin ulcer that is often resistant to most common treatments. It is caused by microvascular disorders and an immunocompromised state which are induced by diabetes mellitus...
  6. doi Left paraduodenal hernia: a rare cause of large bowel obstruction and gangrene
    Abu Bakar Hafeez Bhatti
    Surgical Unit IV, Dow University of Health Sciences and Civil Hospital, Karachi
    J Coll Physicians Surg Pak 22:250-1. 2012
    ..authors here report a case of left para duodenal hernia with simultaneous small and large bowel obstruction and gangrene. The patient underwent emergency laparotomy and generous resection of gangrenous small and large bowel was ..
  7. ncbi Presentation and outcome of purpura fulminans associated with peripheral gangrene in 12 patients at Mayo Clinic
    Mark D P Davis
    Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Acad Dermatol 57:944-56. 2007
    ..Dermatologists may be called to assist in the diagnosis and management of purpura fulminans...
  8. ncbi Disseminated intravascular coagulation complicated by peripheral gangrene in a rhesus macaque (Macaca mulatta) experimentally infected with Plasmodium coatneyi
    Alberto Moreno
    Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    Am J Trop Med Hyg 76:648-54. 2007
    We report the first case of disseminated intravascular coagulation (DIC) complicated by peripheral gangrene induced by Plasmodium coatneyi in rhesus monkeys...
  9. ncbi Peripheral gangrene complicating Salmonella typhi septicaemia in a Gambian infant
    B J Okoko
    Medical Research Council, Fajara, The Gambia, West Africa
    J Trop Pediatr 47:250-1. 2001
    ..septicaemia with a 4-day history of febrile illness, dehydration and severe anaemia, developed bilateral dry gangrene of the hands and feet...
  10. ncbi Heat insoluble cryoglobulin associated with gangrene in multiple myeloma
    Amir Modarressi
    Department of Medicine, Division of Hematology, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
    J Clin Apher 18:190-3. 2003
    ..report a case of a 49 year old man with multiple myeloma and an unusual type I cryoglobulin that caused occlusive gangrene. The cryoglobulin appeared as a milky white precipitate that was resistant to re-suspension and did not dissolve ..
  11. doi [DIC and peripheral gangrene in a severe Plasmodium falciparum malaria: the coagulation-inflammation cycle with Plasmodium falciparum as a model]
    A Tessier-Marteau
    Laboratoire d Hematologie, CHU Angers, Service de Reanimation, CHU d Angers
    Ann Biol Clin (Paris) 67:569-72. 2009
    Peripheral gangrene with disseminated intravascular coagulation (DIC) during severe Plasmodium falciparum malaria has already been described but is unfrequent...
  12. ncbi Cutaneous complications of intravesical treatments for bladder cancer: granulomatous inflammation of the penis following BCG therapy and penile gangrene following mitomycin therapy
    Faraz Kureshi
    Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA
    J Am Acad Dermatol 55:328-31. 2006
    ..The second patient was a 73-year-old man with penile gangrene. Erythema involving his penis and perineum had developed within 24 hours after intravesical administration of ..
  13. ncbi Capnocytophaga canimorsus sepsis with purpura fulminans and symmetrical gangrene following a dog bite in a shelter employee
    Pravin M Deshmukh
    Department of Infectious Diseases, Albany Medical College, Albany, New York, USA
    Am J Med Sci 327:369-72. 2004
    The authors describe a fatal case of purpura fulminans with symmetrical peripheral gangrene and sepsis caused by Capnocytophaga canimorsus in a 45-year-old, previously healthy woman who was bitten by a dog at an animal shelter where she ..
  14. ncbi The prevention of traditional bone setter's gangrene
    M Eshete
    Arba Minch Hospital, Addis Ababa, Ethiopia
    J Bone Joint Surg Br 87:102-3. 2005
    ..retrospective survey in southern Ethiopia revealed that 49 amputations had been performed, 25 of which were for gangrene following tight splintage applied by traditional bone setters...
  15. doi Spontaneous adult transmesentric hernia with bowel gangrene
    R Gomes
    Department of Surgery, Goa Medical College, Bambolim, Goa, India
    Hernia 15:343-5. 2011
    ..We report a rare case of spontaneous transmesenteric hernia of ileum with associated gangrene of bowel caused by a congenital mesenteric defect in a 35-year-old adult male, and review the relevant literature.
  16. pmc Cutaneous polyarteritis nodosa presented with digital gangrene: a case report
    Seung Won Choi
    Department of Internal Medicine, Ulsan University Hospital, College of Medicine, University of Ulsan, Dong Gu, Ulsan, Korea
    J Korean Med Sci 21:371-3. 2006
    ..Therapy with corticosteroid and alprostadil induce a moderate improvement of skin lesions. However, necrosis of the finger got worse and the finger was amputated...
  17. ncbi Laparotomy for visceral ischemia and gangrene
    Karen Woo
    Department of Surgery, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Am Surg 73:1006-8. 2007
    ..Patients were grouped into those who had a "positive laparotomy" with findings of bowel ischemia, bowel gangrene, or both (PL) and those who had a "negative laparotomy" with no evidence of compromised bowel (NL)...
  18. ncbi [Perineal gangrene: clinical and therapeutic features and prognostic analysis of 35 cases]
    Slim Jarboui
    Service de Chirurgie Viscerale, CHI de Poissy, F 78303 Poissy Cedex, France
    Presse Med 37:760-6. 2008
    The objective of this retrospective study of 35 cases of perineal gangrene was to describe their clinical and therapeutic features and to analyze the prognostic factors of mortality.
  19. ncbi Breast gangrene as a complication of puerperal sepsis
    Sameer A Rege
    C 201, Gagangiri Park Cooperative Housing Society, Samata Nagar, Thane West 400606, India
    Arch Surg 137:1441-2. 2002
    b>Gangrene of the breast, although rare, has been reported following anticoagulant treatment, trauma, and infection. Two cases of breast gangrene due to puerperal sepsis have been reported...
  20. ncbi Neonatal gangrene in an extremity of an infant of a diabetic mother
    A Moazzam
    Department of Plastic Surgery, Royal Belfast Hospital for Sick Children, UK
    BJOG 110:74-6. 2003
  21. ncbi Symmetric peripheral gangrene with mixed malaria
    A Agrawal
    Department of Pediatrics, N S C B Medical College, Jabalpur, M P, India
    Indian J Pediatr 74:587-8. 2007
    Symmetric peripheral gangrene (SPG) in a case of mixed malaria (P. falciparum and P. vivax) is a rare and relatively unknown complication of malaria...
  22. ncbi HBO and gas gangrene. A case report
    S Ferraù
    Service of Hyperbaric Medicine, University of Reykjavik City Hospital, Reykjavik, Iceland
    Minerva Anestesiol 67:745-9. 2001
    ..The first clinical appearance showed a gas gangrene of the area...
  23. pmc A review of diagnosis and modes of presentation of tropical idiopathic lower limb gangrene
    A A Musa
    Department of Surgery, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria
    Afr Health Sci 6:49-50. 2006
    Tropical idiopathic lower limb gangrene (TILLG) is also known as Symmetrical gangrene in the African, Idiopathic gangrene in the African and Idiopathic peripheral gangrene of the tropics...
  24. doi Symmetrical peripheral digital gangrene following severe Plasmodium falciparum malaria-induced disseminated intravascular coagulopathy
    Sana Z A Ghafoor
    Department of Dermatology and Wound Healing, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Int Wound J 7:418-22. 2010
    Symmetrical peripheral digital gangrene is a life-changing complication, caused by a pro-thrombotic life-threatening disease, such as disseminated intravascular coagulopathy (DIC) secondary to systemic infection...
  25. ncbi Peripheral gangrene complicating idiopathic and recessive hemolytic uremic syndromes
    B S Kaplan
    Department of Pediatrics, The Children s Hospital of Philadelphia and University of Pennsylvania, 19104, USA
    Pediatr Nephrol 14:985-9. 2000
    Three patients with hemolytic uremic syndrome (HUS) developed peripheral gangrene. Bilateral carotid artery thromboses occurred in one of these patients after recovery from HUS...
  26. ncbi Axial torsion and gangrene of a giant Meckel's diverticulum
    Christos Limas
    Pediatric Surgery Department, University General Hospital of Alexandroupolis, Greece
    J Gastrointestin Liver Dis 15:67-8. 2006
    ..Axial torsion and gangrene of Meckel's diverticulum is the rarest of the complications that have been reported, with this being particularly ..
  27. ncbi Massive gastrointestinal bleeding in infants with ascariasis
    Surasak Sangkhathat
    Pediatric Surgery Unit, Department of Surgery, Faculty of Medicine, Prince of Songkla University, Hadyai, Songkhla, Thailand
    J Pediatr Surg 38:1696-8. 2003
    ..Both infants previously passed roundworms with their stool. The authors conclude that the intestinal ascariasis can be a cause of massive gastrointestinal bleeding, especially in temperate and tropical countries...
  28. ncbi Role of laparoscopic cholecystectomy in the management of gangrenous cholecystitis
    F A Habib
    Department of Surgery, Providence Hospital and Medical Centers, 16001 West Nine Mile Road, 48075, Southfield, MI, USA
    Am J Surg 181:71-5. 2001
    ..Duration of surgery is not significantly prolonged and outcome in terms of morbidity, admission to the intensive care unit, and hospital stay are significantly better in patients in whom laparoscopic cholecystectomy is successful...
  29. doi Priapism and penile gangrene due to thrombotic thrombocytopenic purpura
    Benjamin Kwok
    Nepean Private Hospital, Kingswood NSW
    Urology 75:71-2. 2010
    ..The wound was closed secondarily 2 weeks later. Gangrene of the penis after priapism is very rare...
  30. ncbi Venous gangrene of lower extremities and Staphylococcus aureus sepsis
    H Ibrahim
    Department of Pediatrics, Louisiana State University Health Sciences Center-Shreveport, 1501 Kings Highway, P.O. Box 33932, Shreveport, LA, USA
    J Perinatol 21:136-40. 2001
    This is a study of the venous gangrene of lower extremities and Staphylococcus aureus sepsis. We report on a premature infant who developed phlegmasia cerulea dolens (PCD) in both lower extremities in association with S...
  31. ncbi Axial torsion and gangrene of a giant Meckel's diverticulum mimicking acute appendicitis
    Gulten Kiyak
    Ataturk Teaching and Research Hospital, Second General Surgery Department, Bilkent, Ankara, Turkey
    J Pak Med Assoc 59:408-9. 2009
    ..Complications like intestinal obstruction, bleeding and inflammation of Meckel's diverticulum occur in 4% of patients. The case of a 42-year-old male patient with axial torsion and gangrene of giant Meckel's diverticulum is presented.
  32. ncbi Gangrene secondary to axial torsion in a patient with Meckel's diverticulum
    Mehmet Eser
    Department of General Surgery, Kartal Education and Research Hospital, Istanbul, Turkey
    Int Surg 87:104-6. 2002
    ..This report discusses the case of a 35-year-old woman who was diagnosed with acute abdomen. The laparatomy revealed gangrene of Meckel's diverticulum secondary to its axial torsion...
  33. ncbi Symmetric peripheral gangrene and falciparum malaria
    S Kakati
    Department of Medicine, Assam Medical College, Dibrugarh, Assam
    J Assoc Physicians India 52:498-9. 2004
    Sudden onset symmetric peripheral gangrene (SPG) is a relatively uncommon clinical entity manifested by distal ischemic damage at two or more sites in the absence of large vessel obstruction...
  34. ncbi Multiple arterial thrombi and in utero leg gangrene in an infant of a diabetic mother
    Denise K Long
    Department of Obstetrics and Gynecology, Indiana University, Indianapolis, IN 46202, USA
    J Perinatol 22:424-7. 2002
    This case report is of an infant of a diabetic mother who presented with lower extremity gangrene occurring in utero that necessitated a below the knee amputation at 3 hours of age...
  35. doi Management of ischemic penile gangrene: prompt partial penectomy and other treatment options
    I Ni Chiang
    National Taiwan University Hospital Urology, Taipei, Taiwan
    J Sex Med 5:2725-33. 2008
    Penile gangrene is a rare but troublesome problem with high mortality rates. The etiologies could be infectious, traumatic, or vasculogenic. The treatment algorithm is controversial because of limited case numbers.
  36. doi Severe Plasmodium falciparum malaria with peripheral gangrene
    Raimund Helbok
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Lancet Infect Dis 8:400. 2008
  37. ncbi Gangrene in a child with Plasmodium falciparum malaria
    Pramod Sharma
    The Department of Pediatric Medicine and Surgery, Umaid Hospital, Dr S, N Medical College, Jodhpur
    J Trop Pediatr 51:252-3. 2005
  38. ncbi Ileosigmoidal knotting in children: a review of 9 cases
    S Selcuk Atamanalp
    Department of General Surgery, Ataturk University School of Medicine, Erzurum, Turkey
    World J Surg 31:31-5. 2007
    ..The purpose of this study was to review nine pediatric cases of ileosigmoidal knotting (ISK), which is an unusual form of intestinal obstruction common in adults, characterized by double-loop obstruction...
  39. ncbi Neonatal lower extremity gangrene
    Paras R Kothari
    Department of Pediatric Surgery, LTMMG and General Hospital, Sion, Mumbai 400 002, India
    Indian Pediatr 42:1156-8. 2005
    Four neonates suffering from bilateral lower limb gangrene were referred to us for further management. Two neonates had no contributory etiology...
  40. ncbi Novel detection of parvovirus B19 DNA & IgM antibodies in patients with non-occlusive gangrene of stomach & bowel
    Janak Kishore
    Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Indian J Med Res 131:702-10. 2010
    b>Gangrene of stomach or intestines owing to non-occlusive bowel infarction (NOBI) is a rare event with unknown etiology...
  41. ncbi Successful percutaneous angioplasty and stenting of the radial artery in a patient with chronic upper extremity ischemia and digital gangrene
    Sean Dineen
    Department of Surgery, University of Texas Southwestern, Dallas, Texas 75390, USA
    J Endovasc Ther 14:426-8. 2007
    ..To report percutaneous treatment of a chronic radial artery occlusion in a multimorbid patient with ischemic tissue loss...
  42. doi Gangrene intestine caused by Ascaris lumbricoides; report of 5 cases in children
    Vibha Kawatra
    Department of Pathology, Maulana Azad Medical College and Lok Nayak Hospital Bahadur Shah Zafar Marg, New Delhi 110002, India
    Pathol Res Pract 206:292-4. 2010
    ..It can be asymptomatic or can present with symptoms of acute abdomen. Perforation and torsion with gangrene are its very rare fatal complications but an important cause of mortality in children...
  43. ncbi Neonatal frostbite with gangrene of toes
    Sriram Krishnamurthy
    Department of Pediatrics, University College of Medical Sciences and Guru Tegh Bahadur Hospital, New Delhi, India
    Pediatr Dermatol 26:625-6. 2009
    b>Gangrene of the extremities in the neonatal period is rare. Etiology is not identified in most cases and management is usually conservative...
  44. ncbi Symmetric peripheral gangrene of the lower limbs in a case of complicated falciparum malaria
    P C Bhattacharyya
    Department of Medicine, Downtown Hospital Ltd, Guwahati, Assam, India
    Southeast Asian J Trop Med Public Health 39:589-92. 2008
    Association of symmetric peripheral gangrene (SPG) with falciparum malaria infection is a relatively uncommon clinical entity...
  45. ncbi Ileosigmoid knotting--a case for primary anastomosis
    D Bawa
    Department of Surgery, Jos University Teaching Hospital, Jos, Plateau State, Nigeria
    Niger J Med 17:115-7. 2008
    ..Resection of gangrenous/non-viable bowel followed by primary anastomoses is known to be a viable option for treatment of ileosigmoid knotting. We here report a case of ileosigmoid knot and examined the options for treatment...
  46. pmc Peripheral gangrene in patients with severe falciparum malaria: report of 3 cases
    Vipa Thanachartwet
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Korean J Parasitol 44:139-43. 2006
    Peripheral gangrene, characterized by distal ischemia of the extremities, is a rare complication in patients with falciparum malaria. Patients with this complication have generally undergone early amputation of the affected areas...
  47. ncbi Intrauterine gangrene of the lower extremity in the newborn: a report of two cases
    Mary K Nagai
    Department of Orthopaedic Surgery, Alfred I duPont Hospital for Children, Wilmington, DE 19803, USA
    J Pediatr Orthop 27:499-503. 2007
    We describe 2 cases of intrauterine gangrene involving the lower extremity in 2 unrelated neonates...
  48. ncbi Aluminum foil treatment combined with basic fibroblast growth factor (bFGF) for gangrene of the fingertip caused by collagen disease
    Gan Muneuchi
    Department of Plastic Surgery, Kagawa University, Kagawa, Japan
    Scand J Plast Reconstr Surg Hand Surg 39:312-4. 2005
    ..factor (bFGF) is used for the treatment of various intractable ulcers, there have been no reports of using it for gangrene of the fingertips caused by collagen diseases...
  49. ncbi Warfarin-induced skin necrosis and venous limb gangrene in the setting of heparin-induced thrombocytopenia
    Abhay F Srinivasan
    Section of Hematology Oncology, Department of Medicine, Baylor College of Medicine, Houston, Tex 77030, USA
    Arch Intern Med 164:66-70. 2004
    ..With HIT, it has been suggested that unopposed warfarin can precipitate venous limb gangrene. There are also reports of warfarin-induced skin necrosis...
  50. ncbi Risk factors for major limb amputations in diabetic foot gangrene patients
    Susumu Miyajima
    Department of Dermatology, Osaka Koseinenkin Hospital, 4 2 78, Fukushima ku, Fukushima, Osaka 553 0003, Japan
    Diabetes Res Clin Pract 71:272-9. 2006
    ..0001). Together with early detection and treatment of foot lesions, good blood glucose control and early management of systemic complications such as nephropathy and arteriosclerosis are considered important to avoid major amputations...
  51. ncbi Warfarin-induced limb gangrene in the setting of lung adenocarcinoma
    Liviu Klein
    Department of Medicine, Advocate Illinois Masonic Medical Center, Chicago, Illinois, USA
    Am J Hematol 76:176-9. 2004
    ..5. The platelet count dropped by more than 50%, and he developed venous limb gangrene of the left leg and skin necrosis of the right leg...
  52. ncbi Complete gangrene of penis in patient with arterial vascular disease
    R Gillitzer
    Department of Urology, Johannes Gutenberg University, Mainz, Germany
    Urology 64:1231.e4-6. 2004
    We present a clinical case of distal penile gangrene in a patient with peripheral vaso-occlusive disease that did not correlate with the extension of the intraoperative finding and required total penectomy...
  53. ncbi Hemorheological disorders in patients with type 1 or 2 diabetes mellitus and foot gangrene
    Maia Mantskava
    Microcirculation Research Center, I Beritashvili Institute of Physiology, 14 Gotua St, 0160 Tbilisi, Georgia
    Clin Hemorheol Microcirc 35:307-10. 2006
    ..The disturbed blood fluidity related to the increased RBC aggregability in the microcirculation promotes, in particular, the development of legs gangrene in both types of diabetes mellitus.
  54. ncbi Plasmodium falciparum cerebral malaria complicated by disseminated intravascular coagulation and symmetrical peripheral gangrene: case report and review
    M E Liechti
    Department of Medicine, University Hospital Zurich, 8091 Zurich, Switzerland
    Eur J Clin Microbiol Infect Dis 22:551-4. 2003
    ..cerebral Plasmodium falciparum malaria with disseminated intravascular coagulation and symmetrical peripheral gangrene, ultimately requiring amputation of her left-sided fingertips and toes, is reported...
  55. ncbi Foot gangrene in patients with end-stage renal disease: a case control study
    Mourad Boufi
    Department of Vascular Surgery and Research Unit of CNRS, UMR 7054, Tenon Hospital Assistance Publique Hôpitaux de Paris, University of Paris VI, Saint Antoine Faculty of Medicine, Paris, France
    Angiology 57:355-61. 2006
    ..estimated at 13%, and indications for limb revascularization in patients combining ESRD with stage IV PAD (foot gangrene) are still controversial...
  56. ncbi Ischemia and gangrene of the penis
    Constantine F Harris
    Department of Urology, Temple University School of Medicine, Philadelphia, PA, USA
    J Urol 169:1795. 2003
  57. ncbi Isolated gangrene of the round and falciform liver ligaments: a rare cause of peritonitis: case report and review of the world literature
    Julian E Losanoff
    Department of Surgery, University of Missouri Columbia, USA
    Am Surg 68:751-5. 2002
    Isolated infection and/or gangrene of the round and falciform liver ligaments is among the rarest causes of acute abdomen...
  58. ncbi Perineal ecthyma gangrenosum in infancy and early childhood: septicemic and nonsepticemic forms
    A M Boisseau
    Service of Dermatology, Hopital des Enfants, Bordeaux, France
    J Am Acad Dermatol 27:415-8. 1992
    ..It is secondary to Pseudomonas aeruginosa infection. Most lesions are located in the anogenital and axillary areas, but the route of infection is generally difficult to establish...
  59. ncbi Total gangrene of the oral tongue following intra-aortic balloon pump for cardiogenic shock
    Luc G Morris
    Department of Otolaryngology, New York University School of Medicine, New York, NY 10016, USA
    Otolaryngol Head Neck Surg 137:358-9. 2007
  60. ncbi Risk factors, ethnic differences and mortality associated with lower-extremity gangrene and amputation in diabetes. The WHO Multinational Study of Vascular Disease in Diabetes
    N Chaturvedi
    EURODIAB, Department of Epidemiology and Public Health, University College London, UK
    Diabetologia 44:S65-71. 2001
    ..However, reasons for differences between geographical regions and the degree to which different health care systems could be responsible is not clear...
  61. ncbi Administration of adenoviral vectors induces gangrene in acutely ischemic rat hindlimbs: role of capsid protein-induced inflammation
    L S Brevetti
    Department of Surgery, Division of Vascular Surgery, University of California, San Francisco 94143-0222, USA
    J Vasc Surg 34:489-96. 2001
    ..Unexpectedly, administration of AdeNOS immediately after induction of acute limb ischemia led to limb gangrene. We subsequently sought to define the molecular mechanisms responsible for this unusual effect and to devise ..
  62. ncbi Multiple erythematous nodules and ecthyma gangrenosum as a manifestation of Pseudomonas aeruginosa sepsis in a previously healthy infant
    Murat Duman
    Dokuz Eylul University Faculty of Medicine, Department of Pediatrics, Yzmir, Turkey
    Pediatr Dermatol 23:243-6. 2006
    ..aeruginosa. We report a previously healthy 6-month-old boy who had an uncommon presentation and rare complications during the course of P. aeruginosa sepsis...
  63. ncbi Symmetrical peripheral gangrene
    B D Sharma
    Department of Medicine, VM Medical College and Safdarjung Hospital, New Delhi, India
    Trop Doct 34:2-4. 2004
    Symmetrical peripheral gangrene (SPG), seen in a wide variety of medical conditions presents as symmetrical gangrene of two or more extremities without large vessel obstruction or vasculitis...
  64. ncbi Gangrene of an occipital encephalocele
    Arvind Sinha
    Indian J Pediatr 72:451. 2005
  65. ncbi Post-caesarean Meleney's gangrene revisited
    T Kulkarni
    Department of Surgery, University Hospital of North Staffordshire, UK
    J Obstet Gynaecol 27:428-9. 2007
  66. ncbi Venous limb gangrene during overlapping therapy with warfarin and a direct thrombin inhibitor for immune heparin-induced thrombocytopenia
    Maureen A Smythe
    Department of Pharmaceutical Services, William Beaumont Hospital, Royal Oak, Michigan 48073 6769, USA
    Am J Hematol 71:50-2. 2002
    ..patients with deep-vein thrombosis complicating immune heparin-induced thrombocytopenia who developed venous limb gangrene during overlapping therapy with a direct thrombin inhibitor (lepirudin or argatroban) and warfarin...
  67. ncbi Wet gangrene in hemodialysis patients with calciphylaxisis is associated with a poor prognosis
    C A Davis
    Division of Vascular Surgery, Department of Surgery, The University of Texas Southwestern Medical Center, Dallas, TX 75235-9031, USA
    Cardiovasc Surg 9:565-70. 2001
    ..We report our five-year experience with five patients who developed foot gangrene due to calciphylaxis...
  68. ncbi Venous limb gangrene during warfarin treatment of cancer-associated deep venous thrombosis
    T E Warkentin
    McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada
    Ann Intern Med 135:589-93. 2001
    BACKGROUND: The cause of cancer-associated venous limb gangrene is unknown but could paradoxically be due to warfarin. OBJECTIVE: To determine the pathogenesis of venous gangrene in a patient with cancer. DESIGN: Case report...
  69. ncbi [Fournier's gangrene as a delayed complication of closed hemorrhoidectomy]
    R Gurfinkel
    Plastic Surgery Department, Soroka University Medical Center, Beer Sheva, Israel
    Harefuah 144:394-6, 456, 455. 2005
    Fournier's gangrene is recognized as a synergistic necrotizing fasciitis of the perineum and abdominal wall along with the scrotum and penis in men and the vulva in women...
  70. ncbi Infantile Kawasaki disease and peripheral gangrene
    Amy L Durall
    Department of Anesthesia, Children s Hospital, Boston, Massachusetts, USA
    J Pediatr 149:131-3. 2006
    We report a 1-month-old infant with Kawasaki disease and peripheral gangrene. We advocate using the newly published American Heart Association guidelines advising early laboratory and echocardiogram investigations in infants with fever ..
  71. ncbi Symmetrical peripheral gangrene due to viral gastroenteritis
    R Kashyap
    Department of Medicine, IG Medical College, Shimla HP India
    J Assoc Physicians India 52:500-1. 2004
    A case of multifactorial symmetrical peripheral gangrene due to viral gastroenteritis, shock, dopamine infusion, exposure to low temperature and nonlactose fermenters septicaemia is presented for its rarity and devastating consequences.
  72. ncbi Non-occlusive mesenteric ischemia and its associated intestinal gangrene in acute pancreatitis
    Masahiko Hirota
    Department of Surgery II, Kumamoto University Medical School, Kumamoto City, Kumamoto, Japan
    Pancreatology 3:316-22. 2003
    ..mesenteric ischemia (NOMI) has been defined as diffuse intestinal ischemia that often results in intestinal gangrene in the presence of a patent arterial trunk...
  73. ncbi Trench foot following a collapse: assessment of the feet is essential in the elderly
    Gethin L Williams
    Department of General Surgery, Llandough Hospital, Penarth, Cardiff CF64 2XX, UK
    Age Ageing 34:651-2. 2005
    ..We present a case of bilateral trench foot in such a patient with no prior peripheral vascular disease. Examination of the feet is mandatory for early detection of this rare condition in the collapsed elderly patient...
  74. ncbi Calciphylaxis: have you seen this disease?
    Stuart H Kuschner
    Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Am J Orthop (Belle Mead NJ) 34:449-50. 2005
  75. ncbi Ergotism unresponsive to multiple therapeutic modalities, including sodium nitroprusside, resulting in limb loss
    Khrongwong Musikatavorn
    Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Clin Toxicol (Phila) 46:157-8. 2008
    ..We report a patient with ischemia from ergotamine tartrate who failed to recover with medical therapy, resulting in limb amputation...
  76. ncbi Healing of transmetatarsal amputation in the diabetic patient: is angiography predictive?
    Boulos Toursarkissian
    Division of Vascular Surgery, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Ann Vasc Surg 19:769-73. 2005
    Transmetatarsal amputation (TMA) is a durable reconstruction in the diabetic patient with limited forefoot gangrene. However, predicting TMA healing remains difficult...
  77. ncbi Midfoot amputations expand limb salvage rates for diabetic foot infections
    Patrick A Stone
    Division of Vascular and Endovascular Surgery, University of South Florida, Tampa, FL 33606, USA
    Ann Vasc Surg 19:805-11. 2005
    ..Transtarsal amputations salvaged over half of nonhealing TMAs with excellent functional results...
  78. ncbi Hand ischemia after radial artery cannulation
    R James Valentine
    Division of Vascular Surgery, Department of Surgery, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9031, USA
    J Am Coll Surg 201:18-22. 2005
    ..Hand ischemia is a rare but potentially devastating complication of radial artery cannulation for arterial monitoring. The causes and ultimate outcomes of hand ischemia after radial artery cannulation are unclear...
  79. ncbi [Lower leg amputation due to critical limb ischaemia: morbidity, mortality and rehabilitation potential]
    R W Sprengers
    Universitair Medisch Centrum Utrecht, Utrecht
    Ned Tijdschr Geneeskd 151:2185-91. 2007
    ..3 patients, a female aged 66 years, a male aged 67 years and a female aged 82 years, presented with rest pain or gangrene of their lower extremities as a result of critical limb ischemia (CLI)...
  80. ncbi Management of severe ischemia of the hand following intra-arterial injection
    Marc Righini
    Division of Angiology and Hemostasis, Geneva University Hospital, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Thromb Haemost 94:219-21. 2005
  81. ncbi Percutaneous angioplasty in the diabetic foot
    Dono Antono
    Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia
    Acta Med Indones 39:192-3. 2007
  82. ncbi Iatrogenic arterial injury and foot gangrene. A case report
    L O A Thanni
    Department of Orthopaedics and Traumatology, College of Health Sciences, Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria
    Niger J Clin Pract 10:352-4. 2007
    ..Elective orthopaedic operations on the knee is rarely complicated by arterial injury...
  83. ncbi The management of ischemic heel ulcers and gangrene in the endovascular era
    Hasan H Dosluoglu
    Division of Vascular Surgery, Veterans Administration Western New York Healthcare System, 3495 Bailey Avenue, Buffalo, NY 14215, USA
    Am J Surg 194:600-5. 2007
    The objective of this study was to compare the outcome of patients presenting with heel ulcers or gangrene (HEEL group) with those having lesions in other parts of the foot (non-HEEL group).
  84. ncbi Peripheral vascular occlusions leading to gangrene and amputations in antiphospholipid antibody positive patients
    Ronald A Asherson
    Division of Immunology, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa
    Ann N Y Acad Sci 1108:515-29. 2007
    ..Complicating vasculitis was present in seven of the patients. Five of the patients developed severe peripheral vascular disease during the course of the catastrophic antiphospholipid (Asherson's) syndrome...
  85. pmc Diabetic foot ulcers
    Michael E Edmonds
    Diabetic foot clinic at King s College Hospital, London
    BMJ 332:407-10. 2006
  86. ncbi Three episodes of gracilis free muscle transfer under epidural anaesthesia
    N H Alam
    Department of Plastic and Reconstructive Surgery, Castle Hill Hospital, Castle Road, Cottingham, Hull HU16 5JQ, UK
    J Plast Reconstr Aesthet Surg 59:1463-6. 2006
    ..The inability to undergo general anaesthesia does not preclude free flap surgery in carefully selected patients...
  87. ncbi Purpura fulminans secondary to transient protein C deficiency as a complication of chickenpox infection
    Ali Bay
    Pediatr Dermatol 23:412-3. 2006
  88. ncbi Multiple digital gangrene after a radial artery penetrating injury: a case report
    Ting Lung Lin
    Department of Plastic and Reconstructuve Surgery, Chang Gung Memorial Hospital Kaohsiung Medical Center, Niao Sung Hsiang, Kaohsiung Hsien, Taiwan
    Ann Vasc Surg 21:384-7. 2007
    ..This case revealed that particular attention should be paid to those patients with a radial artery penetration injury to facilitate early detection and implementation of therapy for possible finger ischemia and subsequent gangrene.
  89. doi Myeloproliferative disorder as the cause of peripheral ischemia in a young patient
    Jimmy K F Hon
    Department of Vascular Surgery, St Mary s Hospital, London, UK
    Ann Vasc Surg 22:456-8. 2008
    A 35-year-old patient with rest pain and peripheral gangrene was referred with a diagnosis of Takayasu's disease but had myeloproliferative disorder (primary thrombocythemia)...
  90. ncbi Acute limb ischemia due to ergotism
    Iram Naz
    Department of Surgery, Section of Vascular Surgery, Aga Khan University, Karachi, Pakistan
    J Coll Physicians Surg Pak 16:553-5. 2006
    ..The first patient was a 60 years old woman, who presented with a 15 days history of ischemia of the left arm with gangrene of the fingers and pain in the resting right hand for one day...
  91. ncbi Successful treatment and limb salvage of mucor necrotizing fasciitis after kidney transplantation with posaconazole
    Abigail S Harada
    Department of Medicine, University of Hawai i, John A Burns School of Medicine, Honolulu, HI 96813, USA
    Hawaii Med J 66:68-71. 2007
    ....
  92. ncbi [Postoperative nocardiosis caused by Nocardia otitidiscaviarum: pitfalls and delayed diagnosis]
    F Bonnet
    Service d Anesthesie Reanimation, Assistance Publique Hopitaux de Paris, Hopital Saint Louis, Paris, France
    Ann Fr Anesth Reanim 26:680-4. 2007
    ..Recommendations are proposed regarding physicians' role and optimized microbiological procedures for recognition of slowly growing nocardial strains...
  93. ncbi Multiple peripheral artery occlusions in antiphospholipid syndrome
    Suely Meireles Rezende
    Am J Hematol 82:498. 2007
  94. ncbi [Incidence of pyo-necrotic complications of the diabetic foot syndrome and preferences of specialized care]
    Iu I Pavlov
    Vestn Khir Im I I Grek 164:19-22. 2005
    ..A comparison of the results has shown that treatment and interdisciplinary observation in specialized institutions allowed to reduce lethality and number of high amputations more than two times...
  95. ncbi Hypothenar Hammer Syndrome: rare or underdiagnosed?
    M Abudakka
    Department of Surgery, Burnley General Hospital, Casterton Avenue BB10 2PQ, East Lancashire Hospitals NHS Trust, UK
    Eur J Vasc Endovasc Surg 32:257-60. 2006
    ..In this report we present a case of HHS and discuss the causes and pathogenesis of this syndrome. We review the incidence, clinical characteristics, differential diagnosis, investigation and treatment...
  96. ncbi Modified skew-flap below-knee amputation
    Amitabh Jitendra Dwyer
    Department of Orthopedic Surgery, Christian Medical College and Hospital, Ludhiana, Panjab, India
    Am J Orthop (Belle Mead NJ) 36:123-6. 2007
    ....
  97. ncbi Digital ischemia due to essential thrombocythemia: a case report
    Anastasios Papadonikolakis
    Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Hand Surg Am 32:1053-7. 2007
    This report describes the case of a 34-year-old patient with essential thrombocythemia who presented with Raynaud's syndrome, was refractory to medical treatment, and developed progressive digital gangrene.
  98. ncbi Bilateral lower extremity gangrene requiring amputation associated with heparin-induced thrombocytopenia--a case report
    Brian P Dickinson
    University of California Los Angeles Division of Vascular Surgery, Gonda Goldschmied Vascular Center, Los Angeles, CA 90095, USA
    Vasc Endovascular Surg 40:161-4. 2006
    ..Early and accurate diagnosis of heparin-induced thrombocytopenia requires a high clinical suspicion and may be present despite the absence of serum antibodies...
  99. ncbi Hypereosinophilic syndrome accompanying gangrene of the toes with peripheral arterial occlusion--a case report
    Satoru Funahashi
    Department of Surgery, Section of Vascular Surgery, Saiseikai Yahata General Hospital, Kitakyushu, Japan
    Angiology 57:231-4. 2006
    ..underwent bilateral lumbar sympathectomies because of severe ischemia of the bilateral lower extremities with gangrene of the toes...
  100. ncbi [Angioplasty of the distal anastomosis und runoff arteries of occluded infrainguinal bypasses]
    F Sigala
    Kplus Gefässzentrum Haan, Vaskuläre und Endovaskuläre Chirurgie, St Josef Krankenhaus Haan GmbH, Robert Koch Strasse 16, 42781 Haan
    Zentralbl Chir 131:31-6. 2006
    ....
  101. ncbi Preliminary results of subintimal angioplasty for limb salvage in lower extremities with severe chronic ischemia and limb-threatening ischemia
    Stuart I Myers
    McGuire Research Institute McGuire VA Medical Center, Virginia Commonwealth University, Richmond, VA, USA
    J Vasc Surg 44:1239-46. 2006
    ..This study examined the hypothesis that superficial femoral artery (SFA) subintimal angioplasty (SI-PTA) can maintain limb salvage with minimal complications in patients with symptomatic occlusive arterial disease...

Research Grants71

  1. BLOOD FACTORS AND PERIPHERAL ARTERIAL DISEASE OUTCOMES
    Mary McDermott; Fiscal Year: 2004
    ..15, lower extremity gangrene, ulcer, revascularization, or amputation);, b) functional decline over 48 month follow-up...
  2. Development of a Geometric Forefoot Model: A tool for Clinical Decision Making
    Howard Hillstrom; Fiscal Year: 2007
    ..If not successfully treated this infection could result in gangrene and the necessity for amputation...
  3. Improved Adventitial Sirolimus Therapy for Peripheral Artery Restenosis
    KIRK SEWARD; Fiscal Year: 2010
    ..dramatic rise in the prevalence of PAD, which impairs the ability to walk and causes pain, nonhealing ulcers and gangrene in the lower extremities. It is a significant public health burden and, at its worst, leads to leg amputations...
  4. Evaluation of a novel connexin-based peptide for the treatment of diabetic wounds
    GAUTAM SUDHIR GHATNEKAR; Fiscal Year: 2010
    ..impair the patient's quality of life, require prolonged hospitalization, and may involve infection, gangrene, and amputation...
  5. Evaluation of a novel connexin-based peptide for the treatment of diabetic wounds
    GAUTAM SUDHIR GHATNEKAR; Fiscal Year: 2011
    ..impair the patient's quality of life, require prolonged hospitalization, and may involve infection, gangrene, and amputation...
  6. Glucose monitoring using polarized light
    Gerard L Cote; Fiscal Year: 2010
    ..and fewer secondary complications from diabetes mellitus, such as heart disease, blindness, kidney failure, gangrene, and blindness...
  7. Glucose monitoring using polarized light
    GERARD COTE; Fiscal Year: 2007
    ..and fewer secondary complications from diabetes mellitus, such as heart disease, blindness, kidney failure, gangrene, and blindness...
  8. Glucose monitoring using polarized light
    GERARD COTE; Fiscal Year: 2009
    ..and fewer secondary complications from diabetes mellitus, such as heart disease, blindness, kidney failure, gangrene, and blindness...
  9. Anaerobic Bacteria as Oncopathic Agents for Pancreatic Cancer
    Savio Woo; Fiscal Year: 2009
    ..toxin gene that encodes phospholipase c (Cp/plc-), and showed that the mutant strain can no longer cause gas gangrene in mice...
  10. DEVELOPMENT OF A CD-ROM OF CHROMATOGRAPHIC IMAGES
    David Becker; Fiscal Year: 1993
    ..septicum nontraumatic gas gangrene. C...
  11. Development of a Geometric Forefoot Model: A tool for Clinical Decision Making
    Howard Hillstrom; Fiscal Year: 2006
    ..If not successfully treated this infection could result in gangrene and the necessity for amputation...
  12. Mechanism of spore germination
    Philip C Hanna; Fiscal Year: 2011
    ..anthracis), C. difficile- associated infections (CDI), wound and GI infections, gas gangrene, tetanus, forms of botulism and other serious diseases...
  13. Comparative Genomic Analysis of Clostridium perfringens
    Ian Paulsen; Fiscal Year: 2001
    ..and clinical settings, due to its ability to produce a wide range of deadly toxins and cause diseases such as gas gangrene and enteric infections. C...
  14. GENE EXPRESSION DURING SPORULATION
    PATRICK PIGGOT; Fiscal Year: 2009
    ..perfringens, C. botulinum and C. difficile, the causes of anthrax, tetanus, gas gangrene, botulism and colitis following antibiotic therapy, respectively...
  15. GENE EXPRESSION DURING SPORULATION
    Patrick J Piggot; Fiscal Year: 2010
    ..perfringens, C. botulinum and C. difficile, the causes of anthrax, tetanus, gas gangrene, botulism and colitis following antibiotic therapy, respectively...
  16. GENE EXPRESSION DURING SPORULATION
    PATRICK PIGGOT; Fiscal Year: 2009
    ..perfringens, C. botulinum and C. difficile, the causes of anthrax, tetanus, gas gangrene, botulism and colitis following antibiotic therapy, respectively...
  17. Evaluation of a novel connexin-based peptide for the treatment of diabetic wounds
    Gautam Ghatnekar; Fiscal Year: 2007
    ..impair the patient's quality of life, require prolonged hospitalization, and may involve infection, gangrene, and amputation...
  18. BLOOD FACTORS AND PERIPHERAL ARTERIAL DISEASE OUTCOMES
    Mary McDermott; Fiscal Year: 2002
    ..15, lower extremity gangrene, ulcer, revascularization, or amputation);, b) functional decline over 48 month follow-up...
  19. BLOOD FACTORS AND PERIPHERAL ARTERIAL DISEASE OUTCOMES
    Mary McDermott; Fiscal Year: 2001
    ..15, lower extremity gangrene, ulcer, revascularization, or amputation);, b) functional decline over 48 month follow-up...
  20. BLOOD FACTORS AND PERIPHERAL ARTERIAL DISEASE OUTCOMES
    Mary McDermott; Fiscal Year: 2003
    ..15, lower extremity gangrene, ulcer, revascularization, or amputation);, b) functional decline over 48 month follow-up...
  21. MOLECULAR & CELLULAR BASIS OF HOST-PATHOGEN INTERACTIONS
    Gregory Bohach; Fiscal Year: 2001
    ..epithelial cells; and 4) Phospholipase-C induced platelet-leukocyte interactions and defective diapedesis in gas gangrene. In addition to these four projects, our new virologist and cell biologist will submit research proposal to the ..
  22. MOLECULAR & CELLULAR BASIS OF HOST-PATHOGEN INTERACTIONS
    Gregory Bohach; Fiscal Year: 2002
    ..epithelial cells; and 4) Phospholipase-C induced platelet-leukocyte interactions and defective diapedesis in gas gangrene. In addition to these four projects, our new virologist and cell biologist will submit research proposal to the ..
  23. MOLECULAR & CELLULAR BASIS OF HOST-PATHOGEN INTERACTIONS
    Gregory Bohach; Fiscal Year: 2004
    ..epithelial cells; and 4) Phospholipase-C induced platelet-leukocyte interactions and defective diapedesis in gas gangrene. In addition to these four projects, our new virologist and cell biologist will submit research proposal to the ..
  24. MOLECULAR & CELLULAR BASIS OF HOST-PATHOGEN INTERACTIONS
    Gregory Bohach; Fiscal Year: 2000
    ..epithelial cells; and 4) Phospholipase-C induced platelet-leukocyte interactions and defective diapedesis in gas gangrene. In addition to these four projects, our new virologist and cell biologist will submit research proposal to the ..
  25. MOLECULAR & CELLULAR BASIS OF HOST-PATHOGEN INTERACTIONS
    Gregory Bohach; Fiscal Year: 2003
    ..epithelial cells; and 4) Phospholipase-C induced platelet-leukocyte interactions and defective diapedesis in gas gangrene. In addition to these four projects, our new virologist and cell biologist will submit research proposal to the ..
  26. STUDIES ON CLOSTRIDIUM SEPTICUM LETHAL TOXIN
    Rodney Tweten; Fiscal Year: 1999
    ..The most devastating of these diseases is non-traumatic gas gangrene. The only lethal factor secreted by C. septicum is alpha toxin...
  27. STUDIES ON CLOSTRIDIUM SEPTICUM LETHAL TOXIN
    Rodney Tweten; Fiscal Year: 2000
    ..The most devastating of these diseases is non-traumatic gas gangrene. The only lethal factor secreted by C. septicum is alpha toxin...
  28. STUDIES ON CLOSTRIDIUM SEPTICUM LETHAL TOXIN
    Rodney Tweten; Fiscal Year: 2001
    ..The most devastating of these diseases is non-traumatic gas gangrene. The only lethal factor secreted by C. septicum is alpha toxin...
  29. STUDIES ON CLOSTRIDIUM SEPTICUM LETHAL TOXIN
    Rodney Tweten; Fiscal Year: 2002
    ..The most devastating of these diseases is non-traumatic gas gangrene. The only lethal factor secreted by C. septicum is alpha toxin...
  30. PLATELET-LEUKOCYTE INTERACTIONS & DIAPEDESIS IN GAS
    Amy Bryant; Fiscal Year: 2000
    Clostridium perfringens gas gangrene is the most fulminant necrotizing infection affecting humans...
  31. STUDIES ON CLOSTRIDIUM SEPTICUM LETHAL TOXIN
    Rodney Tweten; Fiscal Year: 2003
    ..The most devastating of these diseases is non-traumatic gas gangrene. The only lethal factor secreted by C. septicum is alpha toxin...
  32. HOMOCYSTEINE AND PROGRESSION OF ATHEROSCLEROSIS
    Lloyd Taylor; Fiscal Year: 1993
    ..surgery, and clinical events indicating disease progression including stroke, transient ischemic attacks, gangrene, and ischemic rest pain. All primary and secondary outcome variables will be assessed in blinded fashion...
  33. HOMOCYSTEINE AND PROGRESSION OF ATHEROSCLEROSIS
    Lloyd Taylor; Fiscal Year: 1991
    ..surgery, and clinical events indicating disease progression including stroke, transient ischemic attacks, gangrene, and ischemic rest pain. All primary and secondary outcome variables will be assessed in blinded fashion...
  34. HOMOCYSTEINE AND PROGRESSION OF ATHEROSCLEROSIS
    Lloyd Taylor; Fiscal Year: 1992
    ..surgery, and clinical events indicating disease progression including stroke, transient ischemic attacks, gangrene, and ischemic rest pain. All primary and secondary outcome variables will be assessed in blinded fashion...
  35. CELLULAR FREE RADICAL TOXICITY MECHANISMS
    OLEN BROWN; Fiscal Year: 1999
    ..life-threatening and limit the oxygen pressure that can be used in HBO therapy, the treatment of choice for gas gangrene and CO poisoning...
  36. Replication deficient adenovirus containing VEGF cDNA to ischemic lower limb of
    Sanjay Rajagopalan; Fiscal Year: 2000
    ..include intermittent claudication (pain on walking), rest pain and loss of tissue integrity in the distal limb (gangrene)...
  37. Role of Progenitor Cells in Hindlimb Revascularization
    Darren Schneider; Fiscal Year: 2006
    ..Critical limb ischemia is a major clinical problem, and current therapies are often unable to prevent gangrene and amputation...
  38. Role of Progenitor Cells in Hindlimb Revascularization
    Darren Schneider; Fiscal Year: 2007
    ..Critical limb ischemia is a major clinical problem, and current therapies are often unable to prevent gangrene and amputation...
  39. Role of Progenitor Cells in Hindlimb Revascularization
    Darren Schneider; Fiscal Year: 2005
    ..Critical limb ischemia is a major clinical problem, and current therapies are often unable to prevent gangrene and amputation...
  40. Role of Progenitor Cells in Hindlimb Revascularization
    Darren Schneider; Fiscal Year: 2004
    ..Critical limb ischemia is a major clinical problem, and current therapies are often unable to prevent gangrene and amputation...
  41. Meeting on the Pathogenesis of Clostridia
    ABRAHAM SONENSHEIN; Fiscal Year: 2003
    ..focus on membrane-active clostridial toxins, which are so important for histotoxic infections such as gas gangrene. In the fifth session, the economically important clostridial veterinary diseases will be discussed...
  42. MRI Correlates of Limb Ischemia in PVD
    Thomas Floyd; Fiscal Year: 2003
    ..PVD results in claudication, tissue ischemia, gangrene, and amputation when not treated aggressively...
  43. MRI Correlates of Limb Ischemia in PVD
    Thomas Floyd; Fiscal Year: 2006
    ..PVD results in claudication, tissue ischemia, gangrene, and amputation when not treated aggressively...
  44. MRI Correlates of Limb Ischemia in PVD
    Thomas Floyd; Fiscal Year: 2007
    ..PVD results in claudication, tissue ischemia, gangrene, and amputation when not treated aggressively...
  45. MRI Correlates of Limb Ischemia in PVD
    Thomas Floyd; Fiscal Year: 2004
    ..PVD results in claudication, tissue ischemia, gangrene, and amputation when not treated aggressively...
  46. MRI Correlates of Limb Ischemia in PVD
    Thomas Floyd; Fiscal Year: 2005
    ..PVD results in claudication, tissue ischemia, gangrene, and amputation when not treated aggressively...
  47. IMPROVED CORONARY ARTERY BYPASS GRAFT OF 3 MM ID
    Michael Szycher; Fiscal Year: 1999
    ..This may lead to arterial stenosis. When this occurs, the consequences range from gangrene, to stroke to myocardial infarction...
  48. High throughput screening of embryonic stem cell differentiation
    NGAN HUANG; Fiscal Year: 2009
    ..occlusive disease of the peripheral arteries of the limbs, causing symptoms such as ischemic ulcerations or gangrene. Biological approaches to improve limb blood flow by regenerating the endothelium seem promising for treatment of ..
  49. Toxin Gene Deleted C. perfringens as an Oral Delivery Vector
    Yue Chen; Fiscal Year: 2007
    ..type A produces two extracellular toxins, alpha toxin (pic) and theta toxin (pfoA) which could cause gas gangrene and pose a potential danger when used as a vaccine vector. Secondly, the C...
  50. High throughput screening of embryonic stem cell differentiation
    Ngan F Huang; Fiscal Year: 2010
    ..occlusive disease of the peripheral arteries of the limbs, causing symptoms such as ischemic ulcerations or gangrene. Biological approaches to improve limb blood flow by regenerating the endothelium seem promising for treatment of ..
  51. Toxin Gene Deleted C. perfringens as an Oral Delivery Vector
    Yue Chen; Fiscal Year: 2006
    ..type A produces two extracellular toxins, alpha toxin (pic) and theta toxin (pfoA) which could cause gas gangrene and pose a potential danger when used as a vaccine vector. Secondly, the C...
  52. Genetic and Cellular Determinants of Arterial Thrombosis
    Roy Silverstein; Fiscal Year: 2006
    Arterial thrombosis as the proximate cause of myocardial infarction, stroke, and limb gangrene remains the most important cause of mortality and morbidity in the USA. Blood platelets play a critical role in initiating arterial thrombi...
  53. Genetic and Cellular Determinants of Arterial Thrombosis
    Roy Silverstein; Fiscal Year: 2007
    Arterial thrombosis as the proximate cause of myocardial infarction, stroke, and limb gangrene remains the most important cause of mortality and morbidity in the USA. Blood platelets play a critical role in initiating arterial thrombi...
  54. STRUCTURAL BASIS OF RELAXIN ACTION
    Christian Schwabe; Fiscal Year: 1999
    ..causes increased peripheral blood flow and thereby healing of trophic ulcerations and reversal of incipient gangrene in the extremities...
  55. STRUCTURAL BASIS OF RELAXIN ACTION
    Christian Schwabe; Fiscal Year: 2000
    ..causes increased peripheral blood flow and thereby healing of trophic ulcerations and reversal of incipient gangrene in the extremities...
  56. Genetic and Cellular Determinants of Arterial Thrombosis
    Roy L Silverstein; Fiscal Year: 2010
    Arterial thrombosis as the proximate cause of myocardial infarction, stroke, and limb gangrene remains the most important cause of mortality and morbidity in the USA. Blood platelets play a critical role in initiating arterial thrombi...
  57. Genetic and Cellular Determinants of Arterial Thrombosis
    Roy Silverstein; Fiscal Year: 2009
    Arterial thrombosis as the proximate cause of myocardial infarction, stroke, and limb gangrene remains the most important cause of mortality and morbidity in the USA. Blood platelets play a critical role in initiating arterial thrombi...
  58. Targeting endothelial arginase to treat diabetes-associated vascular dysfunction
    Dan E Berkowitz; Fiscal Year: 2010
    ..These complications, which can result in cardiovascular disease, blindness, gangrene, kidney disease, and erectile dysfunction, are still major causes of death and disease among people with diabetes...
  59. Non-traditional Cardiovascular Risk Factors in DM type 2
    Peter Reaven; Fiscal Year: 2003
    ..congestive heart failure, invasive vascular therapy (coronary or peripheral), and amputation due to ischemic gangrene; Secondary: angina pectoris, transient ischemic attacks, and peripheral artery disease)...
  60. Non-traditional Cardiovascular Risk Factors in DM type 2
    Peter Reaven; Fiscal Year: 2004
    ..congestive heart failure, invasive vascular therapy (coronary or peripheral), and amputation due to ischemic gangrene; Secondary: angina pectoris, transient ischemic attacks, and peripheral artery disease)...
  61. Non-traditional Cardiovascular Risk Factors in DM type 2
    Peter Reaven; Fiscal Year: 2001
    ..congestive heart failure, invasive vascular therapy (coronary or peripheral), and amputation due to ischemic gangrene; Secondary: angina pectoris, transient ischemic attacks, and peripheral artery disease)...
  62. Mitochondriopathy of Chronically Ischemic Muscle
    Iraklis Pipinos; Fiscal Year: 2007
    ..The manifestations of PAD, including claudication and gangrene, result from decreased energy levels within the affected tissue...
  63. Safety and efficacy of rh-Lactoferrin in Diabetic Ulcers
    Jose Engelmayer; Fiscal Year: 2004
    ..Current therapies are inadequate with diabetic patients often developing gangrene and needing amputation...
  64. Mitochondriopathy of Chronically Ischemic Muscle
    Iraklis Pipinos; Fiscal Year: 2009
    ..The manifestations of PAD, including claudication and gangrene, result from decreased energy levels within the affected tissue...
  65. Non-invasive Monitoring of Perfusion in Diabetics
    Gregory Martin; Fiscal Year: 2005
    ..Infection, gangrene and amputation are common occurrences...
  66. Mitochondriopathy of Chronically Ischemic Muscle
    Iraklis Pipinos; Fiscal Year: 2005
    ..The manifestations of PAD, including claudication and gangrene, result from decreased energy levels within the affected tissue...
  67. Non-invasive Monitoring of Perfusion in Diabetics
    Charles Welch; Fiscal Year: 2006
    ..Infection, gangrene and amputation are common occurrences...
  68. Safety and efficacy of rh-Lactoferrin in Diabetic Ulcers
    Jose Engelmayer; Fiscal Year: 2003
    ..Current therapies are inadequate with diabetic patients often developing gangrene and needing amputation...
  69. Mitochondriopathy of Chronically Ischemic Muscle
    Iraklis Pipinos; Fiscal Year: 2006
    ..The manifestations of PAD, including claudication and gangrene, result from decreased energy levels within the affected tissue...
  70. ARTERIOVENOUS CONNECTION IN EXTREMITY REVASCULARIZATION
    EUGENE BERNSTEIN; Fiscal Year: 1980
    Diffuse atherosclerosis precludes arterial reconstruction by conventional techniques, and results in gangrene and limb loss...
  71. TRANSMURAL TRANSPORT IN BLOOD VESSELS
    Donald Fry; Fiscal Year: 1999
    ..so as to cause human arteriosclerotic diseases such as heart attacks, angina, heart failure, strokes, and gangrene of the extremities...