hemorrhagic shock

Summary

Summary: Acute hemorrhage or excessive fluid loss resulting in HYPOVOLEMIA.

Top Publications

  1. pmc Bench-to-bedside review: latest results in hemorrhagic shock
    Martin K Angele
    Department of Surgery, Klinikum Grosshadern, Ludwig Maximilians University, Marchionistrasse 15, 81377 Munich, Germany
    Crit Care 12:218. 2008
  2. ncbi Treatment of uncontrolled hemorrhagic shock after liver trauma: fatal effects of fluid resuscitation versus improved outcome after vasopressin
    Claus Raedler
    Department of Anesthesiology and Critical Care Medicine, Leopold Franzens University, Anichstrasse 35, 6020 Innsbruck, Austria
    Anesth Analg 98:1759-66, table of contents. 2004
  3. ncbi Efferent vagal fibre stimulation blunts nuclear factor-kappaB activation and protects against hypovolemic hemorrhagic shock
    Salvatore Guarini
    Department of Biomedical Sciences, Section of Pharmacology, University of Modena and Reggio Emilia, Modena, Italy
    Circulation 107:1189-94. 2003
  4. ncbi Changes in the mesenteric lymph proteome induced by hemorrhagic shock
    Anubhav Mittal
    Department of Surgery, Faculty of Medicine and Health Sciences, University of Auckland, New Zealand
    Shock 34:140-9. 2010
  5. ncbi Surgical trauma and immunosuppression: pathophysiology and potential immunomodulatory approaches
    Martin K Angele
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    Langenbecks Arch Surg 390:333-41. 2005
  6. ncbi Vasopressin, but not fluid resuscitation, enhances survival in a liver trauma model with uncontrolled and otherwise lethal hemorrhagic shock in pigs
    Karl H Stadlbauer
    Department of Anesthesiology and Critical Care Medicine, Leopold Franzens University, Innsbruck, Austria
    Anesthesiology 98:699-704. 2003
  7. pmc The epidemiology and modern management of traumatic hemorrhage: US and international perspectives
    David S Kauvar
    United States Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    Crit Care 9:S1-9. 2005
  8. ncbi Functional and morphological changes of the gut barrier during the restitution process after hemorrhagic shock
    Jian xing Chang
    The Second Affiliated Hospital, Sun Yat Sen University, 107 West Yanjiang Road, Guangzhou, 510120, Guangdong Province, China
    World J Gastroenterol 11:5485-91. 2005
  9. ncbi Liver metabolomic changes identify biochemical pathways in hemorrhagic shock
    Drew M Scribner
    Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    J Surg Res 164:e131-9. 2010
  10. ncbi Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation
    Mark Lehnert
    Medical Univ of South Carolina, 280 Calhoun St, PO Box 250140, Charleston, SC 29425, USA
    Am J Physiol Gastrointest Liver Physiol 291:G456-63. 2006

Detail Information

Publications331 found, 100 shown here

  1. pmc Bench-to-bedside review: latest results in hemorrhagic shock
    Martin K Angele
    Department of Surgery, Klinikum Grosshadern, Ludwig Maximilians University, Marchionistrasse 15, 81377 Munich, Germany
    Crit Care 12:218. 2008
    b>Hemorrhagic shock is a leading cause of death in trauma patients worldwide...
  2. ncbi Treatment of uncontrolled hemorrhagic shock after liver trauma: fatal effects of fluid resuscitation versus improved outcome after vasopressin
    Claus Raedler
    Department of Anesthesiology and Critical Care Medicine, Leopold Franzens University, Anichstrasse 35, 6020 Innsbruck, Austria
    Anesth Analg 98:1759-66, table of contents. 2004
    In a porcine model of uncontrolled hemorrhagic shock, we evaluated the effects of vasopressin versus an equal volume of saline placebo versus fluid resuscitation on hemodynamic variables and short-term survival...
  3. ncbi Efferent vagal fibre stimulation blunts nuclear factor-kappaB activation and protects against hypovolemic hemorrhagic shock
    Salvatore Guarini
    Department of Biomedical Sciences, Section of Pharmacology, University of Modena and Reggio Emilia, Modena, Italy
    Circulation 107:1189-94. 2003
    ..We investigated whether electrical stimulation (STIM) of efferent vagus nerves may suppress nuclear factor (NF)-kappaB activation and the inflammatory cascade in hemorrhagic (Hem) shock...
  4. ncbi Changes in the mesenteric lymph proteome induced by hemorrhagic shock
    Anubhav Mittal
    Department of Surgery, Faculty of Medicine and Health Sciences, University of Auckland, New Zealand
    Shock 34:140-9. 2010
    ..mesenteric lymph are now thought to contribute significantly to the development of distant organ failure in hemorrhagic shock. Despite the likely relevance of the protein composition of mesenteric lymph conditioned by hemorrhagic ..
  5. ncbi Surgical trauma and immunosuppression: pathophysiology and potential immunomodulatory approaches
    Martin K Angele
    Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    Langenbecks Arch Surg 390:333-41. 2005
    ..Furthermore, the effect of those mediators on cell-mediated immune responses has been studied...
  6. ncbi Vasopressin, but not fluid resuscitation, enhances survival in a liver trauma model with uncontrolled and otherwise lethal hemorrhagic shock in pigs
    Karl H Stadlbauer
    Department of Anesthesiology and Critical Care Medicine, Leopold Franzens University, Innsbruck, Austria
    Anesthesiology 98:699-704. 2003
    The authors compared the effects of vasopressin fluid resuscitation on survival in a liver trauma model with uncontrolled and otherwise lethal hemorrhagic shock in pigs.
  7. pmc The epidemiology and modern management of traumatic hemorrhage: US and international perspectives
    David S Kauvar
    United States Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    Crit Care 9:S1-9. 2005
    ..We conclude with a discussion of outcome measures for the injured patient within the context of the epidemiology of traumatic injury...
  8. ncbi Functional and morphological changes of the gut barrier during the restitution process after hemorrhagic shock
    Jian xing Chang
    The Second Affiliated Hospital, Sun Yat Sen University, 107 West Yanjiang Road, Guangzhou, 510120, Guangdong Province, China
    World J Gastroenterol 11:5485-91. 2005
    To investigate the functional, morphological changes of the gut barrier during the restitution process after hemorrhagic shock, and the regional differences of the large intestine and small intestine in response to ischemia/reperfusion ..
  9. ncbi Liver metabolomic changes identify biochemical pathways in hemorrhagic shock
    Drew M Scribner
    Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    J Surg Res 164:e131-9. 2010
    Despite ongoing advances in treatment, thousands of patients still die annually from complications due to hemorrhagic shock, a condition causing dramatic physiologic and metabolic changes as cells switch to anaerobic metabolism in ..
  10. ncbi Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation
    Mark Lehnert
    Medical Univ of South Carolina, 280 Calhoun St, PO Box 250140, Charleston, SC 29425, USA
    Am J Physiol Gastrointest Liver Physiol 291:G456-63. 2006
    b>Hemorrhagic shock and resuscitation cause endotoxemia and hepatocellular damage...
  11. ncbi A peptide inhibitor of C-jun N-terminal kinase modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation
    Mark Lehnert
    Department of Trauma Surgery, JW Goethe University, Frankfurt, Germany
    Shock 30:159-65. 2008
    ..These changes are mediated, at least in part, by JNK. Therefore, JNK inhibition deserves further evaluation as a potential treatment option in patients after resuscitated blood loss...
  12. pmc Resuscitation and transfusion principles for traumatic hemorrhagic shock
    Philip C Spinella
    University of Connecticut, Pediatric Intensivist, Department of Pediatrics, Department of Surgery, Connecticut Children s Medical Center, Hartford, CT 06106, USA
    Blood Rev 23:231-40. 2009
    ..has reinvigorated the debate on what the most optimal transfusion strategy is for patients with traumatic hemorrhagic shock. In this review we discuss recently described mechanisms that contribute to traumatic coagulopathy, which ..
  13. ncbi Trauma/hemorrhagic shock mesenteric lymph upregulates adhesion molecule expression and IL-6 production in human umbilical vein endothelial cells
    Saraswati D Dayal
    UMDNJ New Jersey Medical School, Newark 07103, USA
    Shock 17:491-5. 2002
    Trauma/hemorrhagic shock (T/HS) is associated with significant lung injury, which is mainly due to an inflammatory process, resulting from the local activation and subsequent interaction of endothelial cells and leukocytes...
  14. pmc Bench-to-bedside review: oxygen debt and its metabolic correlates as quantifiers of the severity of hemorrhagic and post-traumatic shock
    Dieter Rixen
    Department of Trauma Orthopedic Surgery, University of Witten Herdecke at the Hospital Merheim, Cologne, Germany
    Crit Care 9:441-53. 2005
    ..dog/pig) and humans suggest that oxygen debt or its metabolic correlates may be more useful quantifiers of hemorrhagic shock than estimates of blood loss, volume replacement, blood pressure, or heart rate...
  15. ncbi Fluid resuscitation does not improve renal oxygenation during hemorrhagic shock in rats
    Matthieu Legrand
    Department of Translational Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Anesthesiology 112:119-27. 2010
    The resuscitation strategy for hemorrhagic shock remains controversial, with the kidney being especially prone to hypoxia.
  16. ncbi Kupffer cell activation after no-flow ischemia versus hemorrhagic shock
    Hartmut Jaeschke
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock 72205 7199, USA
    Free Radic Biol Med 33:210-9. 2002
    ..However, the importance of Kupffer cells as source of reactive oxygen formation is unclear in a hemorrhagic shock model...
  17. ncbi Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling
    Jie Fan
    Department of Surgery, School of Medicine, University of Pittsburgh, and Division of Pediatric Surgery, Children s Hospital of Pittsburgh, PA 15213, USA
    J Immunol 178:6573-80. 2007
    b>Hemorrhagic shock/resuscitation (HS/R)-induced generation of reactive oxygen species (ROS) plays an important role in posthemorrhage inflammation and tissue injury...
  18. ncbi Prevention of hemorrhagic shock-induced intestinal tissue injury by glutamine via heme oxygenase-1 induction
    Kana Umeda
    Department of Anesthesiology and Resuscitology, Okayama University Medical School, Okayama, Japan
    Shock 31:40-9. 2009
    b>Hemorrhagic shock (HS) is an oxidative stress that causes intestinal tissue injury. Heme oxygenase 1 (HO-1) is induced by oxidative stress and is thought to play an important role in the protection of tissues from oxidative injury...
  19. ncbi IL-6 is essential for development of gut barrier dysfunction after hemorrhagic shock and resuscitation in mice
    Runkuan Yang
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    Am J Physiol Gastrointest Liver Physiol 285:G621-9. 2003
    ..to determine the role of IL-6 as a mediator of the alterations in gut barrier function that occur after hemorrhagic shock and resuscitation (HS/R)...
  20. ncbi The role of hepatic type 1 plasminogen activator inhibitor (PAI-1) during murine hemorrhagic shock
    Claudio E Lagoa
    Department of Surgery, University of Pittsburgh, S411 B South BST, Pittsburgh, PA 15261, USA
    Hepatology 42:390-9. 2005
    b>Hemorrhagic shock (HS) followed by resuscitation (HS-R) is characterized by profound physiological changes. Even if the patient survives the initial blood loss, these poorly understood changes can lead to morbidity...
  21. pmc Hyperkalemia accompanies hemorrhagic shock and correlates with mortality
    Joel Avancini Rocha Filho
    Department of Anesthesiology, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil
    Clinics (Sao Paulo) 64:591-7. 2009
    ..evaluate the effects of terlipressin versus fluid resuscitation with normal saline, hypertonic saline or hypertonic-hyperoncotic hydroxyethyl starch, on hemodynamics, metabolics, blood loss and short-term survival in hemorrhagic shock.
  22. ncbi Protective effect of carbon monoxide inhalation on lung injury after hemorrhagic shock/resuscitation in rats
    Fumitoshi Kanagawa
    Department of Anesthesiology and Resuscitology, Okayama University Medical School, Okayama, Japan
    J Trauma 69:185-94. 2010
    b>Hemorrhagic shock and resuscitation (HSR) induces pulmonary inflammation that leads to acute lung injury. Carbon monoxide (CO), a by-product of heme catalysis, was shown to have potent cytoprotective and anti-inflammatory effects...
  23. pmc Hypertonic saline resuscitation improves intestinal microcirculation in a rat model of hemorrhagic shock
    El Rasheid Zakaria
    Department of Physiology and Biophysics, University of Louisville, Louisville, KY, USA
    Surgery 140:579-87; discussion 587-8. 2006
    Conventional resuscitation (CR) from hemorrhagic shock (HS) often restores and maintains hemodynamics but fails to restore intestinal perfusion...
  24. ncbi The effect of aprotinin on brain ischemic-reperfusion injury after hemorrhagic shock in rats: an experimental study
    Olcay Eser
    Department of Neurosurgery, Afyon Kocatepe University, Afyonkarahisar, Turkey
    J Trauma 63:373-8. 2007
    ..We aimed to demonstrate the positive effects of the serine protease inhibitor aprotinin on neural ischemia-reperfusion injury and apoptosis in a rat model...
  25. ncbi Employing vasopressin as an adjunct vasopressor in uncontrolled traumatic hemorrhagic shock. Three cases and a brief analysis of the literature
    A C Krismer
    Department of Anesthesiology and Critical Care Medicine, Medical University, Innsbruck, Austria
    Anaesthesist 54:220-4. 2005
    Resuscitation of patients in hemorrhagic shock remains one of the most challenging aspects of trauma care...
  26. ncbi Dobutamine improves liver function after hemorrhagic shock through induction of heme oxygenase-1
    Alexander Raddatz
    Klinik für Anaesthesiologie und Intensivmedizin, Universitat des Saarlandes, D 66421 Homburg Saar, Germany
    Am J Respir Crit Care Med 174:198-207. 2006
    Induction of heme oxygenase-1 (HO-1) protects the liver against reperfusion injury after hemorrhagic shock. Previous data suggest that the beta(1)-adrenoceptor agonist dobutamine induces HO-1 in hepatocytes.
  27. ncbi Effects of arginine vasopressin during resuscitation from hemorrhagic hypotension after traumatic brain injury
    Masamitsu Sanui
    Department of Anesthesiology, Division of Trauma Anesthesia and Critical Care, University of Miami Miller School of Medicine, FL 33136, USA
    Crit Care Med 34:433-8. 2006
    ..Two series of experiments were designed to evaluate whether early arginine vasopressin improves acute outcome following resuscitation from traumatic brain injury and severe hemorrhagic hypotension...
  28. ncbi Hemorrhagic shock induces endothelial cell apoptosis, which is mediated by factors contained in mesenteric lymph
    Qi Lu
    Department of Surgery, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Crit Care Med 32:2464-70. 2004
    Trauma-hemorrhagic shock is one of the leading causes of acute respiratory distress syndrome...
  29. ncbi Proteome and system ontology of hemorrhagic shock: exploring early constitutive changes in postshock mesenteric lymph
    Erik D Peltz
    Department of Surgery, School of Medicine, University of Colorado Denver, Aurora, CO 80204, USA
    Surgery 146:347-57. 2009
    ..We hypothesize that an unbiased inspection of the proteome of PSML will reveal previously unrecognized aberrations in systems biology provoked by hemorrhage-induced mesenteric IR injury in vivo...
  30. ncbi Arginine vasopressin, but not epinephrine, improves survival in uncontrolled hemorrhagic shock after liver trauma in pigs
    Wolfgang G Voelckel
    Departments of Anesthesiology and Critical Care Medicine, Leopold Franzens University, Innsbruck, Austria
    Crit Care Med 31:1160-5. 2003
    ..epinephrine vs. saline placebo on hemodynamic variables, regional blood flow, and short-term survival in an animal model of uncontrolled hemorrhagic shock and delayed fluid resuscitation.
  31. ncbi Impact of vasopressin on hemodynamic and metabolic function in the decompensatory phase of hemorrhagic shock
    Ken B Johnson
    Department of Anesthesiology, University of Utah School of Medicine, Salt Lake City, UT 84132 2304, USA
    J Cardiothorac Vasc Anesth 20:167-72. 2006
    To explore how the potent vasoconstrictive features of vasopressin impact the rate of cardiovascular collapse and metabolic derangements associated with prolonged hemorrhagic shock.
  32. ncbi Splanchnic metabolism during gut ischemia and short-term endotoxin and hemorrhagic shock as evaluated by intravasal microdialysis
    Tobias Backström
    Department of Thoracic Surgery, Karolinska Hospital, Stockholm, Sweden
    Shock 21:572-8. 2004
    ..180 followed by 120 min of reperfusion (n = 5); Group III, endotoxin shock for 5 h (n = 5); and Group IV, hemorrhagic shock for 180 min followed by re-transfusion of shed blood (n = 8)...
  33. ncbi Hypertonic saline resuscitation attenuates neutrophil lung sequestration and transmigration by diminishing leukocyte-endothelial interactions in a two-hit model of hemorrhagic shock and infection
    Jose L Pascual
    Division of General Surgery, McGill University Health Center, Montreal, Quebec, Canada
    J Trauma 54:121-30; discussion 130-2. 2003
    Hypertonic saline (HTS) attenuates polymorphonuclear neutrophil (PMN)-mediated tissue injury after hemorrhagic shock. We hypothesized that HTS resuscitation reduces early in vivo endothelial cell (EC)-PMN interactions and late lung PMN ..
  34. ncbi Successful resuscitation of a traumatic cardiac arrest victim in hemorrhagic shock with vasopressin: a case report and brief review of the literature
    Thorsten Haas
    Department of Anesthesiology and Critical Care Medicine, Leopold Franzens University, Innsbruck, Austria
    J Trauma 57:177-9. 2004
  35. pmc Hypertonic resuscitation modulates the inflammatory response in patients with traumatic hemorrhagic shock
    Eileen M Bulger
    Department of Surgery, University of Washington, Harborview Medical Center, Seattle, WA 98104, USA
    Ann Surg 245:635-41. 2007
    ..To determine the effect of resuscitation with hypertonic saline/dextran (HSD) on the innate immune response after injury...
  36. ncbi D-lactate increases pulmonary apoptosis by restricting phosphorylation of bad and eNOS in a rat model of hemorrhagic shock
    Amin Jaskille
    Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Trauma 57:262-69; discussion 269-70. 2004
    ..These modified solutions however alter the function of apoptotic proteins through an unknown mechanism. We postulated that DL-LR induces apoptosis by restricting the phosphorylation of key apoptotic proteins...
  37. ncbi Improved survival time with combined early blood transfusion and fluid administration in uncontrolled hemorrhagic shock in rats
    Akira Takasu
    Department of Traumatology and Critical Care Medicine, National Defense Medical College, Saitama, Japan
    J Trauma 68:312-6. 2010
    ..To test whether early blood administration combined with crystalloid solution infusion may prolong survival in a clinically relevant model of ongoing uncontrolled life-threatening hemorrhage...
  38. ncbi Reperfusion does not induce oxidative stress but sustained endoplasmic reticulum stress in livers of rats subjected to traumatic-hemorrhagic shock
    Johanna Catharina Duvigneau
    Department of Biomedical Sciences, University of Veterinary Medicine, Veterinaerplatz 1, 1210 Vienna, Austria
    Shock 33:289-98. 2010
    Oxidative stress is believed to accompany reperfusion and to mediate dysfunction of the liver after traumatic-hemorrhagic shock (THS). Recently, endoplasmic reticulum (ER) stress has been suggested as an additional factor...
  39. pmc The anti-inflammatory effects of ulinastatin in trauma patients with hemorrhagic shock
    Kyung hye Park
    Department of Emergency Medicine, Jeju National University Hospital, Jeju, Korea
    J Korean Med Sci 25:128-34. 2010
    ..alpha (TNF-alpha) and interleukin 6 (IL-6), and its effects on the prognosis of patients with traumatic hemorrhagic shock. Nineteen patients who visited the emergency department for traumatic hemorrhagic shock were enrolled...
  40. pmc Silencing of Fas, but not caspase-8, in lung epithelial cells ameliorates pulmonary apoptosis, inflammation, and neutrophil influx after hemorrhagic shock and sepsis
    Mario Perl
    Shock Trauma Research Laboratories, Division of Surgical Research, Providence, RI 02903, USA
    Am J Pathol 167:1545-59. 2005
    ..Mice subjected to hemorrhagic shock and sepsis received either Fas-, caspase-8-, or control-siRNA intratracheally 4 hours after hemorrhage...
  41. ncbi Current concepts in hemorrhagic shock
    Richard P Dutton
    University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201, USA
    Anesthesiol Clin 25:23-34, viii. 2007
    Treatment of hemorrhagic shock continues to evolve. Surgically, the concept of "damage control" has become the standard, with shorter operations focused on the control of life-threatening injuries...
  42. ncbi Trauma-hemorrhagic shock-induced red blood cell damage leads to decreased microcirculatory blood flow
    George W Machiedo
    Department of Surgery, UMD New Jersey Medical School, Newark, New Jersey, USA
    Crit Care Med 37:1000-10. 2009
    To test the hypothesis that trauma-hemorrhagic shock (T/HS)-induced changes in red blood cells (RBC) contribute to the reduction of blood flow in distant organs.
  43. ncbi Hemorrhagic shock induced up-regulation of P-selectin expression is mediated by factors in mesenteric lymph and blunted by mesenteric lymph duct interruption
    C A Adams
    Department of Surgery, UMD-New Jersey Medical School, Newark, New Jersey 07103, USA
    J Trauma 51:625-31; discussion 631-2. 2001
    ..mesenteric lymph duct interruption prevents lung injury and decreases lung neutrophil sequestration after hemorrhagic shock (HS)...
  44. ncbi [Assessment of stroke volume variation and intrathoracic blood volume index on the responsiveness to volume loading in mechanically ventilated canine with hemorrhagic shock]
    Song Qiao Liu
    Department of Critical Care Medicine, Zhong Da Hospital and School of Clinical Medicine, Southeast University, Nanjing 210009, China
    Zhonghua Wai Ke Za Zhi 44:1216-9. 2006
    To assess the significance of stroke volume variation (SVV) and intrathoracic blood volume index (ITBI) on the responsiveness to volume loading in mechanically ventilated canine with hemorrhagic shock.
  45. ncbi Small-volume fluid resuscitation with hypertonic saline prevents inflammation but not mortality in a rat model of hemorrhagic shock
    Soheyl Bahrami
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingenstrasse 13, A 1200, Vienna, Austria
    Shock 25:283-9. 2006
    ..Here, we tested the utility of permissive hypotensive resuscitation with hypertonic fluids in a rat model of hemorrhagic shock. Animals were subjected to massive hemorrhage [mean arterial pressure (MAP) = 30 - 35 mmHg for 2 h until ..
  46. ncbi Exogenous nitric oxide donor and related compounds protect against lung inflammatory response after hemorrhagic shock and resuscitation
    Roberto Anaya-Prado
    Borgess Research Institute, Trauma, Surgery Research Sciences and Molecular Biology, the Departments of Surgery and Research, Michigan State University Kalamazoo Center for Medical Studies, Kalamazoo, Michigan, USA
    J Trauma 57:980-8. 2004
    Resuscitation from hemorrhagic shock triggers an inflammatory response characterized by upregulation of cytokine and adhesion molecule expression, increased leukocyte activity, and accumulation of polymorphonuclear neutrophils in a ..
  47. ncbi Hemorrhagic shock induces an S 100 B increase associated with shock severity
    Linda E Pelinka
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology and Research Center of the Allgemeine Unfallversicherungsanstalt, Vienna, Austria
    Shock 19:422-6. 2003
    ..clinical study, we found an S 100 B increase within the first 24 h in patients with multiple trauma and hemorrhagic shock but without cerebral trauma...
  48. ncbi Twenty-five percent albumin prevents lung injury following shock/resuscitation
    Kinga A Powers
    Department of Surgery, University Health Network, Toronto, Canada
    Crit Care Med 31:2355-63. 2003
    ....
  49. ncbi Hypotensive resuscitation during active hemorrhage: impact on in-hospital mortality
    Richard P Dutton
    R Adams Cowley Shock Trauma Center and the Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Trauma 52:1141-6. 2002
    ..We hypothesized that fluid resuscitation titrated to a lower than normal SBP during the period of active hemorrhage would improve survival in trauma patients presenting to the hospital in hemorrhagic shock.
  50. ncbi Glucosamine administration improves survival rate after severe hemorrhagic shock combined with trauma in rats
    Laszlo G Nöt
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0005, USA
    Shock 28:345-52. 2007
    ..Furthermore, the increase in mean arterial pressure may suggest a vasoactive and/or positive inotropic effect of glucosamine in hypovolemic shock...
  51. ncbi Hepatic transcription factor activation and proinflammatory mediator production is attenuated by hypertonic saline and pentoxifylline resuscitation after hemorrhagic shock
    Jessica Deree
    Division of Trauma and Critical Care, Department of Surgery, University of California San Diego, USA
    J Trauma 64:1230-8; discussion 1238-9. 2008
    ..We hypothesized that the attenuation in hepatic injury observed with HSPTX is associated with the reduction of transcription factor activation and proinflammatory mediator production when compared with Ringer's lactate (RL)...
  52. ncbi Hyperoxic ventilation reduces six-hour mortality after partial fluid resuscitation from hemorrhagic shock
    Jens Meier
    Department of Anesthesiology, Intensive Care Medicine, and Pain Control, J W Goethe University Hospital, Frankfurt, Germany
    Shock 22:240-7. 2004
    ..fluid infusion therapy could also restore adequate tissue oxygenation and prevent death in otherwise lethal hemorrhagic shock. In 14 anesthetized pigs ventilated on room air (Fio(2) 0...
  53. ncbi Hepatoprotection and lethality rescue by histone deacetylase inhibitor valproic acid in fatal hemorrhagic shock
    Earl R Gonzales
    Department of Surgery, Trauma Research and Readiness Institute for Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Trauma 65:554-65. 2008
    ..Therefore, we examined protective effects of VPA administration in lethal hemorrhage and analyzed the patterns of hepatic histone acetylation...
  54. ncbi Modulation of mesenteric lymph flow and composition by direct peritoneal resuscitation from hemorrhagic shock
    Paul J Matheson
    Department of Surgery, University of Louisville, Louisville, KY 40292, USA
    Arch Surg 144:625-34. 2009
    Traditional clinical resuscitation from hemorrhagic shock that focuses on restoring central hemodynamic function does not adequately perfuse the gut...
  55. ncbi Histone deacetylase as therapeutic target in a rodent model of hemorrhagic shock: effect of different resuscitation strategies on lung and liver
    Tom Lin
    Department of Surgery, Washington Hospital Center, Washington, DC, USA
    Surgery 141:784-94. 2007
    ....
  56. ncbi Mild hypothermia during hemorrhagic shock in rats improves survival without significant effects on inflammatory responses
    Xianren Wu
    Department of Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh, PA, USA
    Crit Care Med 31:195-202. 2003
    To explore the hypothesis that the survival benefit of mild, therapeutic hypothermia during hemorrhagic shock is associated with inhibition of lipid peroxidation and the acute inflammatory response.
  57. ncbi Sympathetic nerve activity and heart rate variability during severe hemorrhagic shock in sheep
    Andriy I Batchinsky
    U S Army Institute of Surgical Research, 3400 Rawley E Chambers Avenue, Building 3611, Fort Sam Houston, Texas 78234 6315, USA
    Auton Neurosci 136:43-51. 2007
    In this study we explored direct and indirect measures of autonomic nervous system function, as well as changes in cardiovascular complexity, during hemorrhagic shock (HS).
  58. ncbi Elevated serum pancreatic enzyme levels after hemorrhagic shock predict organ failure and death
    Darren J Malinoski
    Division of Trauma and Critical Care Surgery, UCI Medical Center, 333 City Boulevard West, Suite 705, Orange, CA 92868, USA
    J Trauma 67:445-9. 2009
    ..pancreatic enzymes have been shown in animal models to be associated with multiple organ failure after hemorrhagic shock, independent of pancreatitis...
  59. ncbi Hepatic and pulmonary apoptosis after hemorrhagic shock in swine can be reduced through modifications of conventional Ringer's solution
    Eduardo C Ayuste
    Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    J Trauma 60:52-63. 2006
    ..Our hypothesis was that in a clinically relevant large animal model of hemorrhage, resuscitation with racemic lactated Ringer's solution would induce cellular apoptosis, which can be attenuated by elimination of d-lactate...
  60. ncbi Intravenous injection of trauma-hemorrhagic shock mesenteric lymph causes lung injury that is dependent upon activation of the inducible nitric oxide synthase pathway
    Maheswari Senthil
    Department of Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Ann Surg 246:822-30. 2007
    To test the hypothesis that gut-derived factors carried in trauma-hemorrhagic shock (T/HS) lymph is sufficient to induce lung injury...
  61. pmc Protective effects of fresh frozen plasma on vascular endothelial permeability, coagulation, and resuscitation after hemorrhagic shock are time dependent and diminish between days 0 and 5 after thaw
    Shibani Pati
    Department of Surgery and Center for Translational Injury Research, University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma 69:S55-63. 2010
    ..shown that resuscitation with fresh frozen plasma (FFP) is associated with improved outcome after severe hemorrhagic shock (HS)...
  62. ncbi Early use of vasopressors after injury: caution before constriction
    Jason L Sperry
    Division of Burn, Trauma, Critical Care, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Trauma 64:9-14. 2008
    ..We sought to characterize early vasopressor (EV) use and aggressive early crystalloid resuscitation (ECR) and their association with mortality in severely injured patients...
  63. ncbi PKC plays an important mediated effect in arginine vasopressin induced restoration of vascular responsiveness and calcium sensitization following hemorrhagic shock in rats
    Guangming Yang
    State Key Laboratory of Trauma, Burns and Combined Injury, The 2nd Department of Research Institute of Surgery, Daping Hospital, The Third Military Medical University, Chongqing, PR China
    Eur J Pharmacol 628:148-54. 2010
    ..vasopressin (AVP)-induced restoration of vascular responsiveness and calcium sensitization following hemorrhagic shock. Using both isolated superior mesenteric artery from hemorrhagic shock rats and hypoxia-treated vascular ..
  64. ncbi Evolution in damage control for exsanguinating penetrating abdominal injury
    J W Johnson
    Department of Surgery, Division of Traumatology and Surgical Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Trauma 51:261-9; discussion 269-71. 2001
    ..CONCLUSION: Continued application of DC principles has led to improved survival with PAI. Better control of temperature, experience with the open abdomen, and intensive care unit care may be causative...
  65. ncbi Is resuscitation from hemorrhagic shock limited by blood oxygen-carrying capacity or blood viscosity?
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, California 92037, USA
    Shock 27:380-9. 2007
    Systemic and microvascular hemodynamic responses to volume restoration from hemorrhagic shock were studied in the hamster window chamber model to determine the significance of blood rheological and oxygen transport properties...
  66. ncbi Role of p38 mitogen-activated protein kinase on renal dysfunction after hemorrhagic shock in rats
    Hiroaki Sato
    Department of Forensic Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Shock 24:488-94. 2005
    b>Hemorrhagic shock has been reported to induce renal dysfunction as a consequence of different kinds of local inflammatory response...
  67. ncbi Effects of norepinephrine on static and dynamic preload indicators in experimental hemorrhagic shock
    Semir Nouira
    Medical Intensive Care Unit, Fattouma Bourguiba University Hospital, Monastir 5000, Tunisia
    Crit Care Med 33:2339-43. 2005
    ..the effect of norepinephrine on static (right atrial pressure, pulmonary artery occlusion pressure ) and dynamic (pulse pressure variation and arterial systolic pressure variation) preload indicators in experimental hemorrhagic shock.
  68. ncbi DSM-RX78, a new phosphodiesterase inhibitor, suppresses superoxide anion production in activated human neutrophils and attenuates hemorrhagic shock-induced lung injury in rats
    Huang Ping Yu
    Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
    Biochem Pharmacol 78:983-92. 2009
    Neutrophils are activated following hemorrhagic shock and the accumulation of neutrophils in the lung is associated with lung injury...
  69. pmc Hemorrhagic shock after experimental traumatic brain injury in mice: effect on neuronal death
    Alia Marie Dennis
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 3434 Fifth Avenue, Pittsburgh, PA 15260, USA
    J Neurotrauma 26:889-99. 2009
    Traumatic brain injury (TBI) from blast injury is often complicated by hemorrhagic shock (HS) in victims of terrorist attacks...
  70. pmc Trauma-hemorrhagic shock-induced pulmonary epithelial and endothelial cell injury utilizes different programmed cell death signaling pathways
    Dimtrios Barlos
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey 07103, USA
    Am J Physiol Lung Cell Mol Physiol 296:L404-17. 2009
    Intestinal ischemia after trauma-hemorrhagic shock (T/HS) results in gut barrier dysfunction and the production/release of biologically active and tissue injurious factors in the mesenteric lymph, which, in turn, causes acute lung injury ..
  71. ncbi Reactive oxygen species as mediators of organ dysfunction caused by sepsis, acute respiratory distress syndrome, or hemorrhagic shock: potential benefits of resuscitation with Ringer's ethyl pyruvate solution
    Mitchell P Fink
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Curr Opin Clin Nutr Metab Care 5:167-74. 2002
    ..Ethyl pyruvate, a simple derivative of pyruvic acid, has been shown to be efficacious in several animal models of critical illness, and warrants further evaluation in this regard...
  72. ncbi The cellular, metabolic, and systemic consequences of aggressive fluid resuscitation strategies
    Bryan A Cotton
    Department of General Surgery, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Shock 26:115-21. 2006
    ..Early resuscitation of hemorrhagic shock with predominately saline-based regimens has been associated with cardiac dysfunction and lower cardiac ..
  73. ncbi Tissue hypoxia activates JNK in the liver during hemorrhagic shock
    Carol A McCloskey
    Department of General Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15260, USA
    Shock 22:380-6. 2004
    The earliest signaling pathways responsible for initiating the systemic response to hemorrhagic shock (HS) remain poorly characterized...
  74. ncbi Vasopressin for hemorrhagic shock management: revisiting the potential value in civilian and combat casualty care
    Wolfgang G Voelckel
    Department of Anesthesiology and Critical Care Medicine, AUVA Trauma Center Salzburg, Salzburg, Austria
    J Trauma 69:S69-74. 2010
    ..However, the significance of AVP as a rescue medication for life-threatening hemorrhage has yet to be proven...
  75. pmc Strain-specific effects of probiotics on gut barrier integrity following hemorrhagic shock
    Misha D Luyer
    Department of Surgery, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Infect Immun 73:3686-92. 2005
    ..strains selected for their pathogen exclusion properties on intestinal barrier integrity following hemorrhagic shock. Additionally, the responsiveness of the macrophage cell line RAW 264...
  76. pmc Exogenous nitric oxide induces protection during hemorrhagic shock
    Pedro Cabrales
    La Jolla Bioengineering Institute, 505 Coast Boulevard South Suite 405, La Jolla, CA 92037, United States
    Resuscitation 80:707-12. 2009
    ..the systemic and microvascular hemodynamic changes related to increased nitric oxide (NO) availability during the early phase of hemorrhagic shock. Hemodynamic responses to hemorrhagic shock were studied in the hamster window chamber.
  77. ncbi Targeted resuscitation strategies after injury
    Robert N Bilkovski
    Department of Emergency Medicine, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Curr Opin Crit Care 10:529-38. 2004
    ..The rapid identification and restoration of oxygen debt are central to the resuscitation of the critically ill patient, be it the result of sepsis or trauma...
  78. ncbi Hemorrhagic shock-induced vascular hyporeactivity in the rat: relationship to gene expression of nitric oxide synthase, endothelin-1, and select cytokines in corresponding organs
    Liang Ming Liu
    U S Army Institute of Surgical Research, San Antonio, Texas, USA
    J Surg Res 125:128-36. 2005
    ..To evaluate possible mechanisms involved, the present study investigated the gene expression of iNOS, eNOS, IL-1beta, IL-6, TNF-alpha, and endothelin-1 in the corresponding organs, and the roles of nitric oxide (NO) and endothelin (ET)...
  79. ncbi Improved survival after resuscitation with norepinephrine in a murine model of uncontrolled hemorrhagic shock
    Marie Pierre Poloujadoff
    Hopital Avicenne, Assistance Publique Hopitaux de Paris, Universite Paris 13, France
    Anesthesiology 107:591-6. 2007
    ..However, studies on resuscitation using norepinephrine in uncontrolled hemorrhagic shock are lacking...
  80. ncbi Hypertension-induced dysfunction of circulation in hemorrhagic shock
    Z Radisavljevic
    Shock Trauma Institute, School of Medicine, Loyola University Chicago, Maywood, Illinois 60153, USA
    Am J Hypertens 8:761-7. 1995
    ..concentration of Na+, K+, glucose, and urea were studied in patients with essential hypertension during hemorrhagic shock. All 15 patients had established essential hypertension, and all had massive hemorrhage and shock...
  81. ncbi IL-10 administration attenuates pulmonary neutrophil infiltration and alters pulmonary iNOS activation following hemorrhagic shock
    P Kobbe
    Department of Orthopaedic Surgery, University of Pittsburgh, PA, USA
    Inflamm Res 58:170-4. 2009
    Several studies report immuno-modulatory effects of endogenous IL-10 after trauma. This study investigates the effect of IL-10 administration on systemic and pulmonary inflammation in hemorrhagic shock.
  82. ncbi S-Nitroso-N-acetylpenicillamine (SNAP) during hemorrhagic shock improves mortality as a result of recovery from vascular hyporeactivity
    S Sato
    Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Anesth Analg 90:362-8. 2000
    Nitric oxide donors are protective against hemorrhagic shock (HS). However, no detailed investigation has been performed. We investigated this mechanism using S-nitroso-N-acetylpenicillamine (SNAP)...
  83. ncbi Recombinant humanized monoclonal antibody against CD18 (rhuMAb CD18) in traumatic hemorrhagic shock: results of a phase II clinical trial. Traumatic Shock Group
    P Rhee
    Trauma Services, Washington Hospital Center, DC 20010, USA
    J Trauma 49:611-9; discussion 619-20. 2000
    Activated neutrophils have been shown to play a pivotal role in resuscitation injury after traumatic hemorrhagic shock. Blocking the adhesion of neutrophils with a recombinant humanized monoclonal antibody against CD18 (rhuMAb CD18) may ..
  84. ncbi Emerging paradigm: toll-like receptor 4-sentinel for the detection of tissue damage
    Kevin P Mollen
    Department of Surgery, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Shock 26:430-7. 2006
    ..a body of literature has evolved describing a key role for TLRs in acute injury using rodent models of hemorrhagic shock, ischemia and reperfusion, tissue trauma and wound repair, and various toxic exposures...
  85. pmc Protective role of endogenous carbon monoxide in hepatic microcirculatory dysfunction after hemorrhagic shock in rats
    B H Pannen
    Department of Anesthesiology and Critical Care Medicine, University of Freiburg, D 79106 Freiburg, Germany
    J Clin Invest 102:1220-8. 1998
    ..perfusion, mitochondrial redox state, and bile production in the isolated perfused rat liver after hemorrhagic shock. Administration of tin protoporphyrin-IX (50 microM), a specific inhibitor of the CO generating enzyme heme ..
  86. ncbi Cell protective mechanism of valproic acid in lethal hemorrhagic shock
    Yongqing Li
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Surgery 144:217-24. 2008
    ..demonstrated that valproic acid (VPA), a histone deacetylase inhibitor, can improve animal survival after hemorrhagic shock and protect neurons from hypoxia-induced apoptosis...
  87. ncbi Role of tumor necrosis factor-alpha and interleukin-1beta on lung dysfunction following hemorrhagic shock in rats
    Hiroaki Sato
    Department of Forensic Medicine, School of Medicine, University of Occupational and Environmental Health, Japan
    Med Sci Monit 14:BR79-87. 2008
    b>Hemorrhagic shock occasionally causes a fatal outcome following an outbreak of lung dysfunction, but the precise mechanism has not been clearly elucidated...
  88. pmc Hemorrhagic shock augments lung endothelial cell activation: role of temporal alterations of TLR4 and TLR2
    Yuehua Li
    Department of Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1670-80. 2009
    b>Hemorrhagic shock (HS) due to major trauma predisposes the host to the development of acute lung inflammation and injury...
  89. ncbi DCL-Hb for trauma patients with severe hemorrhagic shock: the European "On-Scene" multicenter study
    Thoralf Kerner
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Campus Virchow Klinikum, Charite, Humboldt Universitat, Augustenburger Platz 1, 13353 Berlin, Germany
    Intensive Care Med 29:378-85. 2003
    A major cause of death in patients with severe hemorrhagic shock following trauma is the subsequent occurrence of multiple organ failure due to tissue hypoxia...
  90. ncbi Encapsulated Bifidobacteria reduced bacterial translocation in rats following hemorrhagic shock and resuscitation
    Xiangcai Ruan
    Department of Vascular Surgery, The First Affiliated Hospital of Sun Yet Sen University, Guangzhou, China
    Nutrition 23:754-61. 2007
    The aim of the present study was to determine the effects of peroral encapsulated Bifidobacteria on intestinal microflora, bacterial translocation (BT), plasma endotoxin, and ileal villi injury in a rat model of hemorrhagic shock.
  91. ncbi Heme arginate pretreatment attenuates pulmonary NF-kappaB and AP-1 activation induced by hemorrhagic shock via heme oxygenase-1 induction
    T Sasaki
    Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine and Dentistry, Japan
    Med Chem 2:271-4. 2006
    b>Hemorrhagic shock followed by resuscitation (HSR) induces oxidative stress that leads to acute lung injury...
  92. ncbi [Hemorrheological changes in irreversible hemorrhagic shock]
    Lian Zhao
    Institute of Transfusion Medicine, Academy of Military Medical Science, Beijing 100850, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 20:159-62. 2008
    To observe the characteristics of changes in hemorheology at the early stage of irreversible hemorrhagic shock in a rodent model.
  93. ncbi [Vasopressin for therapy of persistent traumatic hemorrhagic shock: The VITRIS.at study]
    H G Lienhart
    Univ Klinik für Anästhesie und Allg Intensivmedizin, Medizinische Universitat Innsbruck, Anichstrasse 35, 6020, Innsbruck, Osterreich
    Anaesthesist 56:145-8, 150. 2007
    While fluid management is established in controlled hemorrhagic shock, its use in uncontrolled hemorrhagic shock is being controversially discussed, because it may worsen bleeding...
  94. ncbi Hyperspectral imaging: a new approach to the diagnosis of hemorrhagic shock
    Leopoldo C Cancio
    US Army Institute of Surgical Research, Fort Sam Houston, Texas 78234 6315, USA
    J Trauma 60:1087-95. 2006
    Skin color changes and mottling are frequently described signs of hemorrhagic shock (HEM)...
  95. ncbi [Role of pancreatic enzymes in gut injury secondary to trauma/hemorrhagic shock in rats]
    Han Ping Shi
    Department of Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 24:1137-9. 2004
    To test the hypothesis that pancreatic digestive enzymes are involved in trauma/hemorrhagic shock (T/HS)-induced intestinal injury.
  96. ncbi The splenectomized dog: do we have to say farewell to an established hemorrhagic shock model?
    José Reinaldo Cerqueira Braz
    Anesth Analg 100:1867; author reply 1867. 2005
  97. ncbi Role of p38 mitogen-activated protein kinase on cardiac dysfunction after hemorrhagic shock in rats
    Hiroaki Sato
    Department of Forensic Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
    Shock 28:291-9. 2007
    Cardiac dysfunction is a well-known complication of hemorrhagic shock as a consequence of local inflammatory response...
  98. ncbi [Blood lactate concentrations as predictors of outcome in serious hemorrhagic shock patients]
    Yutaka Yamazaki
    Department of Anesthesia, Yuri Kumiai General Hospital, Yurihonjo
    Masui 55:699-703. 2006
    There is no useful predictor of treatment preventing progress from hemorrhagic shock to systemic inflammatory response syndrome or disseminated intravascular coagulation...
  99. ncbi Detrimental effects of rapid fluid resuscitation on hepatocellular function and survival after hemorrhagic shock
    Kaushal J Shah
    Department of Surgery, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore 21201, USA
    Shock 18:242-7. 2002
    ..that aggressive intravenous fluid resuscitation would aggravate tissue injury in a fixed-volume model of hemorrhagic shock. Unanesthetized chronically prepared male rats were hemorrhaged 33-36 mL/kg for 2.5 h...
  100. ncbi Small volume resuscitation with 3% hypertonic saline solution decrease inflammatory response and attenuates end organ damage after controlled hemorrhagic shock
    Rodrigo Vincenzi
    Research Division, InCor, University of Sao Paulo, School of Medicine, Sao Paulo, Brazil
    Am J Surg 198:407-14. 2009
    ..HS) for the treatment of traumatic brain injury; however, few studies have analyzed the effects of 3% hemorrhagic shock during hemorrhagic shock...
  101. ncbi Hypertonic saline improves tissue oxygenation and reduces systemic and pulmonary inflammatory response caused by hemorrhagic shock
    Valter Gurfinkel
    Department of Clinical Emergencies, Hospital das Clinicas, University of Sao Paulo, Brazil
    J Trauma 54:1137-45. 2003
    The treatment of hemorrhagic shock (HeS) with large volumes of fluid does not ensure an adequate peripheral perfusion or prevent inflammatory activation despite hemodynamic recovery...

Research Grants64

  1. Multi-targeted Countermeasures against Acute and Delayed Effects of OP Exposure
    John A Butera; Fiscal Year: 2013
    ..Inhibitors of PARP-1 have been investigated pre-clinically and clinically for cardiac ischemia, hemorrhagic shock syndrome, stroke, traumatic CNS injury, diabetes, inflammation, and cancer...
  2. Prevention of Acute Lung Injury by IL-6 activated STAT3
    Ana Moran; Fiscal Year: 2010
    Trauma is accompanied frequently by hemorrhagic shock and is the leading cause of death for those under 45 years old in the United States...
  3. Triggers of Abruptio Placentae - A Case Crossover Study of an Ischemic Placental
    Michelle A Williams; Fiscal Year: 2013
    ..association with adverse outcomes in newborns and mothers including preterm delivery, fetal death, maternal hemorrhagic shock, and renal failure...
  4. Intrathoracic Pressure Regulator for Resuscitation
    Keith G Lurie; Fiscal Year: 2011
    ..survival and neurological outcome without adverse effects when using the ITPR to treat cardiac arrest and hemorrhagic shock. Recent pilot studies in humans with intra-operative hypotension provide support for the potential for this ..
  5. MOLECULAR BIOLOGY OF HEMORRHAGIC SHOCK
    Timothy R Billiar; Fiscal Year: 2013
    ..We propose that one of the keys to understanding organ injury resulting from hemorrhagic shock is to characterize the earliest molecular events leading to the initiation and propagation of inflammatory ..
  6. HMG in Post Operative and Traumatic Stress
    Kevin J Tracey; Fiscal Year: 2013
    ..models including severe sepsis, arthritis, pancreatitis, burn injury, acute lung injury, cerebral ischemia, hemorrhagic shock, colitis, and other inflammation and injury syndromes...
  7. Heme Oxygenase Enzymes/Carbon Monoxide in Hepatic Dysfunction from hemorrhage
    BRIAN SCOTT ZUCKERBRAUN; Fiscal Year: 2013
    ..role and mechanism(s) of HO/CO in the regulation of respiration to protect against organ dysfunction from hemorrhagic shock. Specific Aim II...
  8. Mechanisms of trauma and hemorrhage-induced impairment of innate immunity
    Xiao Di Tan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Trauma and hemorrhagic shock are critical surgical conditions that are managed daily by surgeons and physicians in VA medical centers...
  9. Regulation of Intestinal Epithelial Tight Junction Barrier
    Thomas Y Ma; Fiscal Year: 2011
    ..diarrheal syndromes) and systemic inflammatory conditions (including alcoholic liver disease, heat stroke, hemorrhagic shock, and critically ill)...
  10. Resuscitation using novel impedance threshold devices in pediatrics
    Keith G Lurie; Fiscal Year: 2013
    ..pressure, even without fluid resuscitation, improves hemodynamic parameters and outcome in adult porcine hemorrhagic shock. Vascular biology, physiology, and tissue injury mechanisms change as the child matures from infancy through ..
  11. Keratin biomaterial-based fluid for trauma resuscitation
    LUKE BURNETT; Fiscal Year: 2010
    ..Studies in hemorrhagic shock show that survival is primarily determined by the maintenance of functional capillary density (FCD) and ..
  12. A NEW TECHNIQUE FOR TREATING HEMORRHAGIC SHOCK
    Sufan Chien; Fiscal Year: 2013
    ..relationship between tissue high-energy phosphate supplementation and tissue necrosis and apoptosis during hemorrhagic shock. In most western countries, trauma/hemorrhage is the leading cause of death up to the age of 40...
  13. Improvement of Organ Function after Severe Hypovolemia
    Ping Wang; Fiscal Year: 2013
    ..Clinical management of hemorrhagic shock relies on massive and rapid infusion of fluids to maintain blood pressure...
  14. Role of STAT3 in the pathogenesis of Inflammatory Bowel Disease
    Prema Robinson; Fiscal Year: 2013
    ..Mice expressing only Stat3[unreadable] are hyper-responsive to bacterial LPS challenge and are resistant to hemorrhagic shock-induced apoptosis of parenchymal cells within the heart, lung, and liver suggesting that Stat3[unreadable] ..
  15. Biologic Evaluation of Liposome-Encapsulated Hemoglobin
    Vibhudutta Awasthi; Fiscal Year: 2013
    ..survival and cerebral metabol- ism, and serves as a long-circulating and non-toxic oxygen carrier in hemorrhagic shock. The specific aims are to assess: 1) Survival and cerebral metabolism in a rat model of 40% hemorrhage, 2) ..
  16. Autophagy in liver injury
    Jae Sung Kim; Fiscal Year: 2013
    ..precipitating ischemia/reperfusion (I/R) injury which commonly occurs during liver surgery, trauma, hemorrhagic shock and liver transplantation...
  17. Carbon Monoxide Therapy to Prevent Circulatory Collapse and Shock From Hemorrhage
    BRIAN SCOTT ZUCKERBRAUN; Fiscal Year: 2013
    ..application is to study the use of CO as a therapeutic agent and resuscitative adjunct in the treatment of hemorrhagic shock in pre-clinical models...
  18. Caspase-1 and Inflammasome Activation in Traumahemorrhagic Shock
    Melanie J Scott; Fiscal Year: 2013
    ..the inflammatory response and its effects on cellular death and survival pathways following trauma and hemorrhagic shock (HS)...
  19. Mesenteric Lymph Linking Gut & Distant Organ Injury
    Edwin A Deitch; Fiscal Year: 2010
    ..Consequently, understanding the mechanisms by which trauma-hemorrhagic shock (T/HS) leads to MODS is of major health importance in this country...
  20. Induced Reactive Oxygen Species in a 3-D Human Pancreatitis Model in Vitro
    Gregory P Botta; Fiscal Year: 2013
    ..ROS can cause a severe inflammatory reaction instigating severe pain, hemorrhagic shock, acute respiratory distress, or death, however, no in vitro human model yet exists to understand this ..
  21. Impact of Alcohol on Hemorrhagic Shock-Induced Microvascular Dysfunction
    Jerome W Breslin; Fiscal Year: 2012
    ..in the United States remains associated with greater morbidity and mortality from traumatic injury and hemorrhagic shock. Trauma victims with severe hemorrhage have aggravated tissue injury from ischemia-reperfusion injury in the ..
  22. Modulation of Acetylation in the Treatment of Lethal Hemorrhagic Shock
    Hasan B Alam; Fiscal Year: 2012
    ..However, conventional resuscitation can exacerbate cellular injury caused by hemorrhagic shock. At a sub-cellular level, hemorrhagic shock and resuscitation can alter gene expression, and impair the ..
  23. Mechanisms of age-related inflammatory response in hemorrhagic shock
    Basilia Zingarelli; Fiscal Year: 2011
    ..We also have found that mature rats, when subjected to hemorrhagic shock, exhibit a more pronounced lung and liver injury when compared with young rats...
  24. Development of PEG Hemoglobin blood substitute to treat hemorrhagic shock
    Abe Abuchowski; Fiscal Year: 2009
    ..Prolong Pharmaceuticals has developed a unique HBOC product for the treatment of severe hemorrhagic shock consisting of a combination of PEGylated bovine hemoglobin (PEG-Hb) and hypertonic saline (HS)...
  25. Digestive Enzymes and Microvascular Inflammation in Shock
    Geert W Schmid-Schoenbein; Fiscal Year: 2012
    ..It is our hypothesis that in hemorrhagic shock the protective barrier normally provided by the brush border epithelium is compromised and allows access of ..
  26. Dual role of complement in post-ischemic inflammation and recovery
    Stephen Tomlinson; Fiscal Year: 2012
    ..g., hemorrhagic shock, severe burns, sepsis, myocardial infarction, stroke, transplant dysfunction/rejection)...
  27. The Impact of Vasopressin on Mitochondrial Dysfunction in Hemorrhagic Shock
    CARRIE ADELIA SIMS; Fiscal Year: 2013
    ..Scientist Development Award will investigate the development of mitochondrial dysfunction in late stage hemorrhagic shock and the potential benefit of vasopressin during resuscitation...
  28. Overall Application: Trauma Primes Cells
    Anirban Banerjee; Fiscal Year: 2013
    ..our MOF databases have grown substantially to yield novel insights into fundamental problems inherent to (I) hemorrhagic shock, (II), transfusion (III), mechanisms of anti-inflammatory resuscitation...
  29. Intrathoracic Pressure Regulation for the Treatment of Septic Shock
    Keith Lurie; Fiscal Year: 2009
    ..Pressure Regulation (IPR) recently developed and shown to increase circulation and survival rates in hemorrhagic shock and cardiac arrest, during the early resuscitation phase of sepsis...
  30. Co-Inhibitory Molecules and the Pathology of Indirect-Acute Lung Injury
    Alfred Ayala; Fiscal Year: 2013
    ..In this respect, utilizing our dual insult model of iALI, resulting from hemorrhagic shock (Hem;a 'priming'insult) followed by polymicrobial septic challenge (CLP;'triggering'..
  31. A New Therapy for Bowel Ischemia-Reperfusion Injury
    Asha Jacob; Fiscal Year: 2012
    ..RELEVANCE: Intestinal ischemia-reperfusion (I/R) is a common clinical problem in the settings of sepsis, hemorrhagic shock, vascular surgery and small bowel transplantation...
  32. Rational Design of Lipidic Vectors for Mitochondria-Targeted Antioxidants
    Song Li; Fiscal Year: 2013
    ..Therapeutic effects of these novel compounds have been extensively demonstrated in rat hemorrhagic shock model and various radiation models in mice...
  33. Shock, trauma and gut origin of sepsis
    Edwin A Deitch; Fiscal Year: 2012
    ..the mesenteric lymph are key factors in the pathogenesis of acute lung injury in animals subjected to trauma-hemorrhagic shock (T/HS)...
  34. Regulatory Mechanisms for Resolution of Inflammatory Microvascular Leakage
    Jerome W Breslin; Fiscal Year: 2013
    ..permeable form of Rnd3, a Rho family small GTPase, reduces microvascular hyperpermeability in a rat model of hemorrhagic shock. We also have observed with live cell imaging of endothelial cells that lamellipodia formation and turnover ..
  35. Cell Priming, Receptor Cross-talk and Acute Lung Injury
    Mark A Wilson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hemorrhagic shock (HS) resulting from severe trauma promotes the development of systemic inflammatory response syndrome (SIRS) by activating and priming the inflammatory process through as of yet ..
  36. Alcohol intoxication &Shock;specific needs &targeted resuscitation strategies
    Jesse Sulzer; Fiscal Year: 2012
    ..studies from our lab and others have consistently demonstrated impaired counterregulatory response to hemorrhagic shock (HS) during acute alcohol intoxication (AAI), as evidenced by greater hypotension in response to blood loss, ..
  37. Adjunctive Peritoneal Resuscitation in Hemorrhagic Shock
    Jason Wayne Smith; Fiscal Year: 2013
    ..achieve his goal of becoming an independent investigator focusing on clinical and translational research in hemorrhagic shock and inflammation. Dr...
  38. Apoptotic Signaling Induces Hyperpermeability Following Hemorrhagic Shock
    Ed W Childs; Fiscal Year: 2010
    ..regulation of endothelial cell-cell adherens junctions to prevent microvascular hyperpermeability following hemorrhagic shock. Fluid loss from the circulation is a major factor in compromising cardiovascular homeostasis following ..
  39. Resveratrol as an adjunct to resuscitation fluid following hemorrhage injury
    RAGHAVAN PILLAI RAJU; Fiscal Year: 2013
    ..Our hypothesis is that resveratrol reduces organ injury following hemorrhagic shock and therefore it can be used as an adjunct to resuscitation fluid...
  40. Effects of Damage Control Resuscitation on the Inflammatory Response to Hemorrhag
    Timothy A Pritts; Fiscal Year: 2012
    ..long term research goals are to become an independent surgeon scientist investigating the pathophysiology of hemorrhagic shock and resuscitation...
  41. Anemia and the Chronic Hyperadrenergic State following Major Trauma
    Alicia M Mohr; Fiscal Year: 2013
    ..Our overall goal is to develop treatment strategies for this persistent anemia. Injury and hemorrhagic shock worsen bone marrow (BM) dysfunction and inhibit the differentiation of hematopoietic progenitor cells (HPC) ..
  42. Device for Measuring Capillary Blood Flow and the Onset of Shock
    David E Wolf; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The onset of hemorrhagic shock is a major cause of death in emergency departments and trauma centers. Currently there is no clinically accepted quantitative monitor of the onset of hemorrhagic shock...
  43. TRAINING IN TRAUMA AND SEPSIS RESEARCH
    Timothy R Billiar; Fiscal Year: 2013
    ..Much of the research is supported by a P50 Trauma Center Grant entitled "The Molecular Biology of Hemorrhagic Shock"...
  44. A Real-Time, Minimally Invasive Monitoring System for Early Detection of Shock
    David F Wilson; Fiscal Year: 2010
    ..These measurements can be used to predict the early onset of hemorrhagic shock, quantify the efficacy of cardiac resuscitation, and improve the standard of care for critically ill ..
  45. Postdoctoral Training Program in Trauma and Hemorrhagic Shock
    John B Holcomb; Fiscal Year: 2013
    ..focus of this training grant is described in the title, "Postdoctoral Training Program in Trauma and Hemorrhagic Shock," and has led to 148 publications in peer-reviewed journals, as well as another 60 published abstracts in ..
  46. Direct Peritoneal Resuscitation from Hypovolemic Shock
    Richard Garrison; Fiscal Year: 2007
    The pathophysiology of Hemorrhagic shock consists of disruption of the cellular metabolic functions endothelial barrier properties, redistribution of body fluids and electrolytes, a systemic inflammatory response, and a deleterious ..
  47. Novel xanthine oxidase inhibitor for hemorrhagic shock
    Pal Pacher; Fiscal Year: 2001
    ..intended to establish a new pharmacologic approach to save the lives of severely injured trauma victims with hemorrhagic shock. Inhibition of the purine degradative enzyme xanthine oxidase (XO) shows clear benefit in experimental in ..
  48. INTRAVENOUS FLUID THERAPY AND HEAD INJURY
    Steven Shackford; Fiscal Year: 1990
    ..pressure, cerbral blood flow, cerebral electrical activity and cerebral water content in a procine model of hemorrhagic shock and head injury...
  49. MECHANISMS OF POST-INJURY ORGAN FAILURE
    ERNEST EUGENE MOORE; Fiscal Year: 2013
    ..The principal animal model will consist of hemorrhagic shock and tissue injury, and the basic investigation will include therapeutic modulation of inflammation...
  50. Carbon Monoxide to Prevent Circulatory Collapse
    Leo Otterbein; Fiscal Year: 2007
    ..of injury, early intervention and therapeutics that can delay or prevent the progression to irreversible hemorrhagic shock need to be elucidated...
  51. Syndecan shedding after trauma and hemorrhagic shock
    Rosemary A Kozar; Fiscal Year: 2013
    ..gap in the understanding between syndecan-1 (sdc-1) shedding and mortality in severely injured patients in hemorrhagic shock (HS)...
  52. Resuscitation using novel impedance threshold devices in pediatrics
    Keith Lurie; Fiscal Year: 2007
    ..pressure, even without fluid resuscitation, improves hemodynamic parameters and outcome in adult porcine hemorrhagic shock. Vascular biology, physiology, and tissue injury mechanisms change as the child matures from infancy through ..
  53. Role of SLc11a1 Gen in Warm Ischemia-Reperfusion Injury
    Samuel Wyllie; Fiscal Year: 2006
    ..in surgical techniques and pharmacological interventions have improved the outcome of liver resections, hemorrhagic shock, and organ transplantation, injury, rejection and eventual organ failure due to Ischemia-reperfusion (I/R) ..
  54. GLU6PASE AND 6P2K/FBASE GENE REGULATION IN SEPSIS
    SUBIR MAITRA; Fiscal Year: 2001
    ..that gene expression of Glu-6-Pase and 6PF2K/FBPase are reciprocally modulated during hyperglycemic phase of hemorrhagic shock. In this proposal, we are focusing on the regulation of expression of these two genes as models of hormonal ..
  55. BLOOD FLOW IN THE DENERVATED ISCHEMIC REPERFUSED LIVER
    ANTHONY KOO; Fiscal Year: 1990
    ..problem of ischemia and reperfusion in the liver is clinically encountered in liver transplanation and in hemorrhagic shock. In liver transplantation, the donor liver is denervated and non-perfused by blood (an ischemic organ), but ..
  56. PHARMACOLOGY OF ANESTHETICS IN HEMORRHAGIC SHOCK
    Ken Johnson; Fiscal Year: 2002
    ..In the setting of hemorrhagic shock, intravenous agents can produce adverse hemodynamic consequences and prolonged duration of anesthetic effect...
  57. Metabolic-Inflammatory Systems in Irreversible Shock
    Juan Carlos Puyana; Fiscal Year: 2007
    ..on the severity of the hemorrhage and the time lag between injury and hemostasis, some patients with hemorrhagic shock may enter into irreversible circulatory collapse, despite resuscitation...
  58. The Role of Bcl-2 in Ischemia-Reperfusion Injury
    Robert Winn; Fiscal Year: 2006
    Ischemia with or without reperfusion occurs in a variety of diseases including myocardial infarction, stroke, hemorrhagic shock and organ transplantation...
  59. A Novel Resuscitation for Hemorrhagic Shock: AM/AMBP-1
    Rongqian Wu; Fiscal Year: 2009
    ..to further develop a novel therapeutic approach to save the lives of severely injured trauma victims with hemorrhagic shock. Most trauma deaths result either from insufficient tissue perfusion due to excessive blood loss, or the ..
  60. Anti-Inflammatory effect of Cholinergic Pathway:Ischemia
    Elahe Crockett; Fiscal Year: 2005
    ..injury occurs in a wide spectrum of clinically important disorders such as myocardial infarction, stroke, hemorrhagic shock, and organ transplantation...
  61. INFLUENCE OF AGING ON MITOCHONDRIAL GENE EXPRESSION FOLLOWING TRAUMA-HEMORRHAGE
    Raghavan Raju; Fiscal Year: 2009
    ..It is well known that cardiovascular functions are markedly depressed following trauma-hemorrhagic shock despite fluid resuscitation...
  62. Innate Immunity in Gastrointestinal Ischemia
    Melanie Hart; Fiscal Year: 2006
    Gastrointestinal ischemia-reperfusion (GI/R) is a common clinical problem in the settings of sepsis hemorrhagic shock, vascular surgery and small bowel transplantation...
  63. Hemorrhagic Shock and Pancreatic Enzyme Products
    David Hoyt; Fiscal Year: 2007
    b>Hemorrhagic shock is accompanied by a strong inflammatory reaction, the origin of which has been hypothesized in the past to be associated with specific mediators such as endotoxin, oxygen free radicals, cytokines and platelet ..
  64. ENERGY HOMEOSTASIS BY SPECIFIC ORGANS IN SHOCK
    Frederick Pearce; Fiscal Year: 1992
    ..the maintenance of homeostasis and potential contribution to the onset of decompensation of homeostasis in hemorrhagic shock. Our working hypotheses are: 1) The loss of tolerance and ultimately death from persisting hypovolemic shock ..