gliosis

Summary

Summary: The production of a dense fibrous network of neuroglia; includes astrocytosis, which is a proliferation of astrocytes in the area of a degenerative lesion.

Top Publications

  1. ncbi Astrocyte activation and reactive gliosis
    Milos Pekny
    The Arvid Carlsson Institute for Neuroscience, Institute of Clinical Neuroscience, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Glia 50:427-34. 2005
  2. pmc Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: evidence against inflammation as a driving force for amyloid deposition
    Paramita Chakrabarty
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    FASEB J 24:548-59. 2010
  3. pmc Molecular dissection of reactive astrogliosis and glial scar formation
    Michael V Sofroniew
    Department of Neurobiology, University of California Los Angeles, Los Angeles, CA 90095 1763, USA
    Trends Neurosci 32:638-47. 2009
  4. pmc Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain
    Annalisa Buffo
    Institute for Stem Cell Research, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstadter Landstrasse 1, 85764 Neuherberg Munich, Germany
    Proc Natl Acad Sci U S A 105:3581-6. 2008
  5. ncbi Cellular signaling and factors involved in Müller cell gliosis: neuroprotective and detrimental effects
    Andreas Bringmann
    Department of Ophthalmology and Eye Hospital, University of Leipzig, Liebigstrasse 10 14, D 04103 Leipzig, Germany
    Prog Retin Eye Res 28:423-51. 2009
  6. ncbi Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury
    Kristina A Kigerl
    Integrated Biomedical Science Graduate Program, College of Medicine, Ohio State University, Columbus, Ohio, USA
    J Neurochem 102:37-50. 2007
  7. ncbi The stem cell potential of glia: lessons from reactive gliosis
    Stefanie Robel
    Physiological Genomics, Ludwig Maximilians University of Munich, Germany
    Nat Rev Neurosci 12:88-104. 2011
  8. ncbi The role of astrocytes and complement system in neural plasticity
    Milos Pekny
    Center for Brain Repair and Rehabilitation, Department of Clinical Neuroscience and Rehabilitation, Institute for Neuroscience and Physiology at Sahlgrenska Academy Göteborg University, 405 30 Goteborg, Sweden
    Int Rev Neurobiol 82:95-111. 2007
  9. pmc Selective induction of astrocytic gliosis generates deficits in neuronal inhibition
    Pavel I Ortinski
    Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Nat Neurosci 13:584-91. 2010
  10. ncbi Longitudinal in vivo imaging of retinal gliosis in a diabetic mouse model
    Saravana Kumar
    Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore
    Exp Eye Res 91:530-6. 2010

Detail Information

Publications347 found, 100 shown here

  1. ncbi Astrocyte activation and reactive gliosis
    Milos Pekny
    The Arvid Carlsson Institute for Neuroscience, Institute of Clinical Neuroscience, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Glia 50:427-34. 2005
    ..The process of astrocyte activation remains rather enigmatic and results in so-called "reactive gliosis," a reaction with specific structural and functional characteristics...
  2. pmc Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: evidence against inflammation as a driving force for amyloid deposition
    Paramita Chakrabarty
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    FASEB J 24:548-59. 2010
    ..mIL-6 expression resulted in extensive gliosis and concurrently attenuated Abeta deposition in TgCRND8 mouse brains...
  3. pmc Molecular dissection of reactive astrogliosis and glial scar formation
    Michael V Sofroniew
    Department of Neurobiology, University of California Los Angeles, Los Angeles, CA 90095 1763, USA
    Trends Neurosci 32:638-47. 2009
    ..This article reviews developments in the signaling mechanisms that regulate specific aspects of reactive astrogliosis and highlights the potential to identify novel therapeutic molecular targets for diverse neurological disorders...
  4. pmc Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain
    Annalisa Buffo
    Institute for Stem Cell Research, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstadter Landstrasse 1, 85764 Neuherberg Munich, Germany
    Proc Natl Acad Sci U S A 105:3581-6. 2008
    Reactive gliosis is the universal reaction to brain injury, but the precise origin and subsequent fate of the glial cells reacting to injury are unknown...
  5. ncbi Cellular signaling and factors involved in Müller cell gliosis: neuroprotective and detrimental effects
    Andreas Bringmann
    Department of Ophthalmology and Eye Hospital, University of Leipzig, Liebigstrasse 10 14, D 04103 Leipzig, Germany
    Prog Retin Eye Res 28:423-51. 2009
    ..However, Müller cell gliosis can also contribute to neurodegeneration and impedes regenerative processes in the retinal tissue by the ..
  6. ncbi Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury
    Kristina A Kigerl
    Integrated Biomedical Science Graduate Program, College of Medicine, Ohio State University, Columbus, Ohio, USA
    J Neurochem 102:37-50. 2007
    ..Together, these data suggest that in the absence of pathogens, TLR2 and TLR4 are important for coordinating post-injury sequelae and perhaps in regulating inflammation and gliosis after SCI.
  7. ncbi The stem cell potential of glia: lessons from reactive gliosis
    Stefanie Robel
    Physiological Genomics, Ludwig Maximilians University of Munich, Germany
    Nat Rev Neurosci 12:88-104. 2011
    ..following brain injury, glia outside these niches acquire or reactivate stem cell potential as part of reactive gliosis. Recent studies have begun to uncover the molecular pathways involved in this process...
  8. ncbi The role of astrocytes and complement system in neural plasticity
    Milos Pekny
    Center for Brain Repair and Rehabilitation, Department of Clinical Neuroscience and Rehabilitation, Institute for Neuroscience and Physiology at Sahlgrenska Academy Göteborg University, 405 30 Goteborg, Sweden
    Int Rev Neurobiol 82:95-111. 2007
    ..neurotrauma, brain ischemia or neurodegenerative diseases, astrocytes become reactive (which is known as reactive gliosis) and this is accompanied by an altered expression of many genes...
  9. pmc Selective induction of astrocytic gliosis generates deficits in neuronal inhibition
    Pavel I Ortinski
    Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Nat Neurosci 13:584-91. 2010
    ..Thus, reactive astrocytosis could generate local synaptic perturbations, leading to broader functional deficits associated with neurologic disease...
  10. ncbi Longitudinal in vivo imaging of retinal gliosis in a diabetic mouse model
    Saravana Kumar
    Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore
    Exp Eye Res 91:530-6. 2010
    In this study, we visualize and quantify retinal gliosis in vivo for monitoring early diabetic retinopathy (DR) in a transgenic mouse model...
  11. ncbi Stab wound injury of the zebrafish telencephalon: a model for comparative analysis of reactive gliosis
    Emily Violette Baumgart
    Institute for Stem Cell Research, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
    Glia 60:343-57. 2012
    ..Invasive injury in the adult zebrafish telencephalon may therefore provide a useful model to untangle the molecular mechanisms involved in these beneficial glial reactions...
  12. pmc Determining the threshold for alcohol-induced brain damage: new evidence with gliosis markers
    Dayna M Hayes
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536 0596, USA
    Alcohol Clin Exp Res 37:425-34. 2013
    ..Little is known about the threshold of the damaging effects of alcohol. Therefore, these experiments sought to determine a threshold for brain damage using various markers of neurodegeneration...
  13. pmc Searching for neuropathology: gliosis in schizophrenia
    Tatiana P Schnieder
    Biopsychology and Behavioral Neuroscience Doctoral Program, City University of New York, New York, New York, USA
    Biol Psychiatry 69:134-9. 2011
    ..A sufficiently large autopsy study, weighted toward younger subjects, could provide a definitive answer, which if positive could be a major step toward finding an underlying pathological process...
  14. pmc Ciliary neurotrophic factor induces genes associated with inflammation and gliosis in the retina: a gene profiling study of flow-sorted, Müller cells
    Wei Xue
    Department of Ophthalmology, Northwestern University Feinberg Medical School, Chicago, Illinois, United States of America
    PLoS ONE 6:e20326. 2011
    ..We have, therefore, examined gene expression dynamics of purified Müller (glial) cells exposed to CNTF in vivo...
  15. pmc The contribution of gliosis to diffusion tensor anisotropy and tractography following traumatic brain injury: validation in the rat using Fourier analysis of stained tissue sections
    Matthew D Budde
    Neuroscience Research Centre, Milwaukee, WI 53226, USA
    Brain 134:2248-60. 2011
    ..62, P = 0.04) with the coherent organization of reactive astrocytes (i.e. gliosis) and was not attributed to axons. By comparison, a decrease in white matter anisotropy (P < 0...
  16. ncbi Mutant mice with small amounts of BubR1 display accelerated age-related gliosis
    Tyler K Hartman
    Department of Pediatric Adolescent Medicine, Mayo Clinic, College of Medicine, Rochester, MN 55905, United States
    Neurobiol Aging 28:921-7. 2007
    ..Levels of both GFAP and CD11b further increased with age. Our results demonstrate that BubR1 acts to prevent cerebral gliosis of both astrocytes and microglial cells, and suggest a role for BubR1 in the aging process of the brain.
  17. pmc Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain
    Y Zhu
    Center for Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9133, USA
    Genes Dev 15:859-76. 2001
    ..These results indicate that NF1-deficient neurons are capable of inducing reactive astrogliosis via a non-cell autonomous mechanism...
  18. ncbi Gliosis and brain remodeling after treatment of stroke in rats with marrow stromal cells
    Yi Li
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, MI 48202, USA
    Glia 49:407-17. 2005
    ..Brain tissue repair is an ongoing process with reactive gliosis, which persists for at least 4 months after stroke...
  19. ncbi Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain
    M Ingelsson
    Harvard Medical School, Massachusetts General Hospital, Boston
    Neurology 62:925-31. 2004
    ..Pathologic changes in the Alzheimer disease (AD) brain occur in a hierarchical neuroanatomical pattern affecting cortical, subcortical, and limbic regions...
  20. ncbi MAPK signal transduction underlying brain inflammation and gliosis as therapeutic target
    Bozena Kaminska
    Laboratory of Transcription Regulation, Nencki Institute of Experimental Biology, 3 Pasteur Str, Warsaw, Poland
    Anat Rec (Hoboken) 292:1902-13. 2009
    ..mechanisms of inflammatory signal transduction in neurological disorders and in in vitro models of inflammation/gliosis. Mitogen-activated protein kinases (MAPKs) are a family of serine/threonine protein kinases responsible for most ..
  21. pmc Endothelin-1 regulates astrocyte proliferation and reactive gliosis via a JNK/c-Jun signaling pathway
    Ana Gadea
    Center for Neuroscience Research, Children s National Medical Center, Washington, DC 20010, USA
    J Neurosci 28:2394-408. 2008
    Reactive gliosis is characterized by enhanced glial fibrillary acidic protein (GFAP) expression, cellular hypertrophy, and astrocyte proliferation. The cellular and molecular mechanisms underlying this process are still largely undefined...
  22. ncbi Nrf2 deficiency potentiates methamphetamine-induced dopaminergic axonal damage and gliosis in the striatum
    Noelia Granado
    Instituto Cajal, CSIC, Madrid, Spain
    Glia 59:1850-63. 2011
    Oxidative stress that correlates with damage to nigrostriatal dopaminergic neurons and reactive gliosis in the basal ganglia is a hallmark of methamphetamine (METH) toxicity...
  23. ncbi Efficacy of Rho-kinase inhibition in promoting cell survival and reducing reactive gliosis in the rodent retina
    Aysegül Tura
    University Eye Hospital of the Center of Ophthalmology at the Eberhard Karls University of Tübingen, Tubingen, Germany
    Invest Ophthalmol Vis Sci 50:452-61. 2009
    ..To analyze the outcomes of Rho-kinase (ROCK) inhibition on retinal cell survival and glial reactivity under adverse conditions...
  24. ncbi The bright side of the glial scar in CNS repair
    Asya Rolls
    Asya Rolls, Ravid Shechter and Michal Schwartz are at the Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Nat Rev Neurosci 10:235-41. 2009
    ..However, increasing evidence suggests a beneficial role for this scar tissue as part of the endogenous local immune regulation and repair process. How can these opposing effects be reconciled? Perhaps it is all a matter of timing...
  25. ncbi Beneficial effects of alpha-lipoic acid plus vitamin E on neurological deficit, reactive gliosis and neuronal remodeling in the penumbra of the ischemic rat brain
    O Gonzalez-Perez
    Division de Neurociencias, Centro de Investigación Biomédica de Occidente CIBO del Instituto Mexicano del Seguro Social IMSS, Sierra Mojada 800, Guadalajara Jalisco 44340, Mexico
    Neurosci Lett 321:100-4. 2002
    ..The beneficial effects of this antioxidant mixture suggest that it may be valuable for the treatment of cerebral ischemia in humans...
  26. ncbi Transient inflammation in neurogenic regions after irradiation of the developing brain
    Marie Kalm
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
    Radiat Res 171:66-76. 2009
    ..It remains to be elucidated whether these transient changes are involved in the persistent effects of radiation observed on neurogenesis and cognition in rodents...
  27. pmc Injury-independent induction of reactive gliosis in retina by loss of function of the LIM homeodomain transcription factor Lhx2
    Jimmy de Melo
    Departments of Neuroscience, Center for High Throughput Biology, and Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 109:4657-62. 2012
    ..the LIM homeodomain transcription factor Lhx2 from mature Müller glia leads to the induction of reactive retinal gliosis in the absence of injury...
  28. ncbi Purinergic 2Y1 receptor stimulation decreases cerebral edema and reactive gliosis in a traumatic brain injury model
    Lora Talley Watts
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio School of Medicine, TX 78229 3904, USA
    J Neurotrauma 30:55-66. 2013
    ..measurements in both cortical and hippocampal slices also revealed significant neuronal swelling and reactive gliosis. Treatment of mice with 2MeSADP (100 μM) or MRS2365 (100 μM) 30 min after trauma significantly reduced ..
  29. pmc Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's disease
    Alberto Serrano-Pozo
    Massachusetts General Hospital Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Am J Pathol 179:1373-84. 2011
    ..They also suggest that reactive glia might contribute to the ongoing neurodegeneration...
  30. pmc Activin A is essential for neurogenesis following neurodegeneration
    Andrea Abdipranoto-Cowley
    Neuroscience Program, The Garvan Institute of Medical Research, Sydney, Australia
    Stem Cells 27:1330-46. 2009
    ..normal adult hippocampus and also, following lipopolysaccharide administration, had a potent inhibitory effect on gliosis in vivo and on microglial proliferation in vivo and in vitro...
  31. ncbi Ladostigil prevents gliosis, oxidative-nitrative stress and memory deficits induced by intracerebroventricular injection of streptozotocin in rats
    Shai Shoham
    Research Department, Herzog Hospital, Jerusalem, Israel
    Neuropharmacology 52:836-43. 2007
    ..Taken together the data support the role of glial activation and oxidative-nitrative stress in discrete brain areas in the aetiology of memory deficits and indicate a potential mechanism for their prevention by drug treatment...
  32. pmc Human and mouse microglia express connexin36, and functional gap junctions are formed between rodent microglia and neurons
    K Dobrenis
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci Res 82:306-15. 2005
    ....
  33. pmc Mild hypothermia causes differential, time-dependent changes in cytokine expression and gliosis following endothelin-1-induced transient focal cerebral ischemia
    An Gaëlle Ceulemans
    Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neuroscience, Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels, Belgium
    J Neuroinflammation 8:60. 2011
    ..This study is the first to investigate whether this neuroprotection occurs through modulation of the neuroinflammatory response after stroke in a time-dependent manner...
  34. pmc Long-term gliosis and molecular changes in the cervical spinal cord of the rhesus monkey after traumatic brain injury
    Kumi Nagamoto-Combs
    Department of Anatomy and Cell Biology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58202, USA
    J Neurotrauma 27:565-85. 2010
    ..Taken together, these changes in the non-human primate spinal cord support a long-term trophic/tropic role for reactive microglia, in particular, during functional and structural recovery after TBI...
  35. ncbi Therapeutic approaches to inflammation in neurodegenerative disease
    Andis Klegeris
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia, Canada
    Curr Opin Neurol 20:351-7. 2007
    ..Here we review recent advances in our understanding of one such disorder, Parkinson's disease, in which anti-inflammatory drugs are now becoming a new therapeutic focus...
  36. ncbi Reduced retina microglial activation and improved optic nerve integrity with minocycline treatment in the DBA/2J mouse model of glaucoma
    Alejandra Bosco
    Department of Neurobiology, University of Utah, Salt Lake City, Utah 84132, USA
    Invest Ophthalmol Vis Sci 49:1437-46. 2008
    ..The authors investigated the potential contribution of retinal microglia activation to glaucoma progression in the DBA/2J chronic mouse glaucoma model...
  37. ncbi Cognitive decline following major surgery is associated with gliosis, β-amyloid accumulation, and τ phosphorylation in old mice
    Yanjie Wan
    Department of Anesthesiology, Gongli Hospital, Pudong, Shanghai, China
    Crit Care Med 38:2190-8. 2010
    ..We sought to determine whether postoperative cognitive dysfunction in old mice is associated with the pathogenesis of Alzheimer's disease...
  38. pmc IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in rats
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Pain 135:232-9. 2008
    ..05) and inhibited NR1 phosphorylation compared to saline control. The results suggest that spinal IL-1beta is produced by astrocytes and enhances NR1 phosphorylation to facilitate inflammatory pain...
  39. ncbi Axonal regeneration and lack of astrocytic gliosis in EphA4-deficient mice
    Yona Goldshmit
    Center for Neuroscience and School of Physiotherapy, University of Melbourne, Melbourne, Victoria 3010, Australia
    J Neurosci 24:10064-73. 2004
    ..EphA4 expression was upregulated on astrocytes at the lesion site in wild-type mice, whereas astrocytic gliosis and the glial scar were greatly reduced in lesioned EphA4-/- spinal cords...
  40. ncbi Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts
    Lisa Fellner
    Division of Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Austria
    Acta Neuropathol 121:675-93. 2011
    ..Finally, major therapeutic strategies targeting glial pathology in α-synucleinopathies as well as current pitfalls for disease-modification in clinical trials are discussed...
  41. pmc Cell death/proliferation and alterations in glial morphology contribute to changes in diffusivity in the rat hippocampus after hypoxia-ischemia
    Miroslava Anderova
    Institute of Experimental Medicine, Department of Cellular Neurophysiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Cereb Blood Flow Metab 31:894-907. 2011
    ..In the early phases of reperfusion (1 to 3 days) neuronal cell death, glial proliferation, and developing gliosis were accompanied by an ADC(W) decrease and tortuosity increase...
  42. ncbi Redox regulation of glial inflammatory response to lipopolysaccharide and interferongamma
    Siddharama Pawate
    Department of Neurology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci Res 77:540-51. 2004
    ....
  43. pmc Egr-1 regulates expression of the glial scar component phosphacan in astrocytes after experimental stroke
    Heike Beck
    Institute for Clinical Molecular Biology and Tumor Genetics, German Research Center for Environmental Health, Helmholtz Center Munich, Munich, Germany
    Am J Pathol 173:77-92. 2008
    ..The process of gliosis has been well described, but the mechanisms regulating the robust production of scar components after injury ..
  44. ncbi Reactive nonproliferative gliosis predominates in a chronic mouse model of glaucoma
    D M Inman
    Department of Neurosurgery, University of Washington, Seattle, Washington 98104, USA
    Glia 55:942-53. 2007
    In many CNS diseases, proliferation becomes dysregulated; cells divide and participate in pathological processes. Gliosis is a fundamental CNS response to trauma or disease in which cell hypertrophy and proliferation play prominent roles...
  45. ncbi Regeneration beyond the glial scar
    Jerry Silver
    Department of Neurosciences, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
    Nat Rev Neurosci 5:146-56. 2004
  46. pmc A versatile 3D culture model facilitates monitoring of astrocytes undergoing reactive gliosis
    Emma East
    Department of Life Sciences, The Open University, Milton Keynes, UK
    J Tissue Eng Regen Med 3:634-46. 2009
    ..The transition of astrocytes into this reactive phenotype (reactive gliosis) is a potential therapeutic target, but glial scar formation has proved difficult to study in monolayer cultures ..
  47. ncbi Bone morphogenetic proteins promote gliosis in demyelinating spinal cord lesions
    Molly L Fuller
    Department of Neurosciences and Center for Translational Neuroscience, Case School of Medicine, Cleveland, OH 44106, USA
    Ann Neurol 62:288-300. 2007
    ..To determine the role of bone morphogenetic proteins (BMPs) in stimulating glial scar formation in demyelinating lesions of the adult spinal cord...
  48. pmc Fibrosis and diseases of the eye
    Martin Friedlander
    Department of Cell Biology, The Scripps Research Institute, and Division of Ophthalmology, Scripps Clinic, La Jolla, CA 92037, USA
    J Clin Invest 117:576-86. 2007
    ..The recent development of progenitor and/or stem cell technologies holds promise for the treatment of currently incurable ocular diseases...
  49. ncbi Intermittent hypoxia during sleep induces reactive gliosis and limited neuronal death in rats: implications for sleep apnea
    Rolando Xavier Aviles-Reyes
    Instituto de Biologia Celular y Neurociencia Prof E De Robertis, Facultad de Medicina, Universidad de Buenos Aires, Calle Paraguay 2155 3er piso 1121, Ciudad de Buenos Aires, Argentina
    J Neurochem 112:854-69. 2010
    ..Reactive gliosis has a drastic effect on neuronal survival and circuitry and in this study we examined the neuro-glial response in ..
  50. pmc A new in vitro model of the glial scar inhibits axon growth
    Ina B Wanner
    Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, USA
    Glia 56:1691-709. 2008
    ..c) 2008 Wiley-Liss, Inc...
  51. ncbi Bmi1 loss produces an increase in astroglial cells and a decrease in neural stem cell population and proliferation
    Dusan Zencak
    Jules Gonin Eye Hospital, Department of Ophthalmology, Lausanne University Medical School, 1004 Lausanne, Switzerland
    J Neurosci 25:5774-83. 2005
    ..Bmi1(-/-) mice also presented more astrocytes at birth, and a generalized gliosis at postnatal day 30...
  52. ncbi Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS
    Thomas W Gould
    Department of Neurobiology and Anatomy and Program in Neuroscience, Wake Forest University, Winston Salem, North Carolina 27157 1010, USA
    J Neurosci 26:8774-86. 2006
    ..Furthermore, they suggest a novel, cell death-independent role for Bax in facilitating mutant SOD1-mediated motor denervation...
  53. ncbi Metastasis infiltration: an investigation of the postoperative brain-tumor interface
    Bethwel Raore
    Department of Neurological Surgery, Emory University, Atlanta, GA, USA
    Int J Radiat Oncol Biol Phys 81:1075-80. 2011
    ....
  54. ncbi Agmatine-promoted angiogenesis, neurogenesis, and inhibition of gliosis-reduced traumatic brain injury in rats
    Jinn Rung Kuo
    Institute of Clinical Medicine, School of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Trauma 71:E87-93. 2011
    The mechanisms of agmatine-induced neuroprotective effects in traumatic brain injury (TBI) remain unclear. This study was to test whether inhibition of gliosis, angiogenesis, and neurogenesis attenuating TBI could be agmatine stimulated.
  55. ncbi Inflammation and gliosis in neurological diseases--clinical implications
    Anna Członkowska
    2nd Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland
    J Neuroimmunol 231:78-85. 2011
    ..Manipulation of the inflammation is now one of the approaches in the treatment of the various diseases of the CNS...
  56. pmc Inhibition of reactive gliosis attenuates excitotoxicity-mediated death of retinal ganglion cells
    Bhagyalaxmi S Ganesh
    Eye Research Institute of Oakland University, Rochester, Minnesota, United States of America
    PLoS ONE 6:e18305. 2011
    Reactive gliosis is a hallmark of many retinal neurodegenerative conditions, including glaucoma...
  57. ncbi Chemically induced neuronal damage and gliosis: enhanced expression of the proinflammatory chemokine, monocyte chemoattractant protein (MCP)-1, without a corresponding increase in proinflammatory cytokines(1)
    A R Little
    TMBB HELD, MS 3014, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505 2888, USA
    Neuroscience 115:307-20. 2002
    ..Administration of trimethyltin (TMT) to the rat results in loss of hippocampal neurons and an ensuing gliosis without BBB compromise...
  58. ncbi beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity
    H Zheng
    Department of Genetics and Molecular Biology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Cell 81:525-31. 1995
    ..In addition, four out of six homozygous mice showed reactive gliosis at 14 weeks of age, suggesting an impaired neuronal function as a result of the APP-null mutation.
  59. ncbi Regional differences between grey and white matter in cuprizone induced demyelination
    Viktoria Gudi
    Department of Neurology, Hannover Medical School, Hannover, Germany
    Brain Res 1283:127-38. 2009
    ..The time course and dynamics of demyelination differ in the corpus callosum and in the cortex, suggesting different underlying pathomechanisms...
  60. pmc Reactive gliosis and the multicellular response to CNS damage and disease
    Joshua E Burda
    Department of Neurobiology and Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90095 1763, USA
    Neuron 81:229-48. 2014
    ..In some cases, considerable information is available, in others, comparatively little, as examined and reviewed here. ..
  61. ncbi An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss
    David W Hampton
    Cambridge Centre for Brain Repair, University of Cambridge, ED Adrian Building, Forvie Site, Robinson Way, Cambridge, CB2 2PY UK
    J Neuroimmunol 201:200-11. 2008
    ..In this study we sought to characterise the pathology of chronic EAE in ABH mice. In addition to marked gliosis, we report substantial demyelination, remyelination and axonal and neuronal loss...
  62. ncbi Reactive oxygen species regulate prosurvival ERK1/2 signaling and bFGF expression in gliosis within the retina
    Gillian Groeger
    Cell Development and Disease Laboratory, Department of Biochemistry, Biosciences Institute, University College Cork, Cork, Ireland
    Invest Ophthalmol Vis Sci 53:6645-54. 2012
    b>Gliosis is the response of glial cells within retinal tissue to injury. It can be beneficial in the short term, but if the response is extended it can lead to scar formation, which contributes to blindness...
  63. pmc Local disruption of glial adenosine homeostasis in mice associates with focal electrographic seizures: a first step in epileptogenesis?
    Tianfu Li
    Robert S Dow Neurobiology Laboratories, Legacy Research Institute, Portland, Oregon 97232, USA
    Glia 60:83-95. 2012
    ..A secondary event, here mimicked by brain-wide disruption of adenosine signaling, is likely required to turn pre-existing subclinical seizures into a clinical seizure phenotype...
  64. ncbi Regulation of chondroitin sulphate proteoglycan and reactive gliosis after spinal cord transection: effects of peripheral nerve graft and fibroblast growth factor 1
    M J Lee
    Graduate Institute of Biochemical Sciences and Technology, Chaoyang University of Technology, Taichung, Taiwan
    Neuropathol Appl Neurobiol 37:585-99. 2011
    ..This project studied the effect of PN graft and FGF-1 on white matter degeneration following spinal cord injury...
  65. ncbi Astrogliosis in the adult and developing CNS: is there a role for proinflammatory cytokines?
    A R Little
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Neurotoxicology 22:607-18. 2001
    ..lines of evidence argue against this view, including (a) suppression of cytokine expression does not suppress gliosis, (b) gliosis can occur in the absence of enhanced expression of cytokines, (c) elevations in brain cytokines can ..
  66. ncbi Genistein inhibits aggregation of exogenous amyloid-beta₁₋₄₀ and alleviates astrogliosis in the hippocampus of rats
    Maryam Bagheri
    Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Brain Res 1429:145-54. 2012
    ..0001), CA1 (P=0.03), and CA3 (P=0.002); an increased number of iNOS-expressing cells (P=0.01) and gliosis. Genistein given to rats by gavage 1h before injection of Aβ(1-40) inhibited the formation of Aβ(1-40) positive ..
  67. ncbi Interleukin-1 beta is required for the early evolution of reactive astrogliosis following CNS lesion
    L M Herx
    Department of Clinical Neurosciences and Oncology, Faculty of Medicine, University of Calgary, Alberta, Canada
    J Neuropathol Exp Neurol 60:961-71. 2001
    ..These findings suggest that the rapid production of IL-1beta following trauma plays a beneficial role in initiating astrogliosis in an attempt to restore the integrity of the BBB and seal off the wound site...
  68. pmc BMPR1a and BMPR1b signaling exert opposing effects on gliosis after spinal cord injury
    Vibhu Sahni
    Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 30:1839-55. 2010
    ..We investigated the role of bone morphogenetic protein (BMP) signaling in gliosis after SCI and find that BMPR1a and BMPR1b signaling exerts opposing effects on hypertrophy...
  69. ncbi Trimethyltin-induced neurotoxicity: gene expression pathway analysis, q-RT-PCR and immunoblotting reveal early effects associated with hippocampal damage and gliosis
    A R Little
    Molecular Neurotoxicology Laboratory, Health Effects Research Laboratory, Centers for Disease Control and Prevention NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Neurotoxicol Teratol 34:72-82. 2012
    ..These observations provide new insight into early events associated with neuronal degeneration and associated glial activation that may serve as the basis for discovery and development of biomarkers of neurotoxicity...
  70. ncbi Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model
    Siva Sundara Kumar Durairajan
    School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong
    Neurobiol Aging 33:2903-19. 2012
    ..Our results suggest that BBR provides neuroprotective effects in TgCRND8 mice through regulating APP processing and that further investigation of the BBR for therapeutic use in treating AD is warranted...
  71. pmc The surface immobilization of the neural adhesion molecule L1 on neural probes and its effect on neuronal density and gliosis at the probe/tissue interface
    Erdrin Azemi
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Biomaterials 32:681-92. 2011
    Brain tissue inflammatory responses, including neuronal loss and gliosis at the neural electrode/tissue interface, limit the recording stability and longevity of neural probes...
  72. ncbi EPO reduces reactive gliosis and stimulates neurotrophin expression in Muller cells
    Liu Mei Hu
    Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
    Front Biosci (Elite Ed) 3:1541-55. 2011
    ..Exogenous EPO exerts neuroprotective and neurotrophic functions by attenuating reactive gliosis and promoting neurotrophic factors in Muller cells in diabetic retina...
  73. pmc Early cytokine elevation, PrPres deposition, and gliosis in mouse scrapie: no effect on disease by deletion of cytokine genes IL-12p40 and IL-12p35
    Déborah Tribouillard-Tanvier
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Virol 86:10377-83. 2012
    ..The goal of our current research was to determine the relationship between cytokine responses, gliosis, and neuropathology during prion disease...
  74. ncbi The age-related gliosis and accompanying deficit in spatial learning are unaffected by dimebon
    Thelma R Cowley
    Trinity College Institute of Neuroscience and Physiology Department, Trinity College, Dublin, Ireland
    Neurochem Res 38:1190-5. 2013
    ..We conclude that, despite its cognitive enhancing effects in some models, dimebon failed to modulate the deficit in spatial learning in aged rats and the evidence suggests that the drug does not possess anti-inflammatory properties...
  75. pmc Ablation of neurons expressing agouti-related protein activates fos and gliosis in postsynaptic target regions
    Qi Wu
    Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 28:9218-26. 2008
    ..Furthermore, glial cell activation in target areas of AgRP neurons appears to be a result of excitotoxicity...
  76. ncbi Effects of high cholesterol diet on gliosis in apolipoprotein E knockout mice. Implications for Alzheimer's disease and stroke
    M Crisby
    Neurotec Department, Divisions of Clinical and Experimental Geriatrics, Karolinska University Hospital Huddinge, Karolinska Institutet, SE 141 86 Stockholm, Sweden
    Neurosci Lett 369:87-92. 2004
    ..The long time exposure to HC diet combined with apoE deficiency resulted in a synergistic effect on the expression of NQO1 in the brain...
  77. pmc AAV1/2-mediated CNS gene delivery of dominant-negative CCL2 mutant suppresses gliosis, beta-amyloidosis, and learning impairment of APP/PS1 mice
    Tomomi Kiyota
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    Mol Ther 17:803-9. 2009
    ..Our data support the idea that the AAV1/2 system is a useful tool for CNS gene delivery, and suppression of CCL2 may be a therapeutic target for the amelioration of AD-related neuroinflammation...
  78. ncbi Control of Müller glial cell proliferation and activation following retinal injury
    M A Dyer
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Neurosci 3:873-80. 2000
    ..Following neuronal damage, Müller cells undergo reactive gliosis, which is characterized by proliferation and changes in gene expression...
  79. pmc PEX13 deficiency in mouse brain as a model of Zellweger syndrome: abnormal cerebellum formation, reactive gliosis and oxidative stress
    C Catharina Müller
    Eskitis Institute for Cell and Molecular Therapies, and School of Biomolecular and Physical Sciences, Griffith University, Nathan, Brisbane, Queensland 4111, Australia
    Dis Model Mech 4:104-19. 2011
    ..Thus, PEX13-deficient mice provide a valuable animal model for investigating the molecular basis and treatment of ZS cerebellar pathology...
  80. ncbi Upregulation of EphA4 on astrocytes potentially mediates astrocytic gliosis after cortical lesion in the marmoset monkey
    Yona Goldshmit
    Australian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia
    J Neurotrauma 27:1321-32. 2010
    ..These results in a nonhuman primate model highlight the importance of developing pharmacotherapeutic approaches to block these molecules following brain injury...
  81. ncbi Microglia activation influences dye coupling and Cx43 expression of the astrocytic network
    Pedro M Faustmann
    Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Bochum, Germany
    Glia 42:101-8. 2003
    ....
  82. pmc Withaferin A targets intermediate filaments glial fibrillary acidic protein and vimentin in a model of retinal gliosis
    Paola Bargagna-Mohan
    Departmentsof Ophthalmology and Visual Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 285:7657-69. 2010
    b>Gliosis is a biological process that occurs during injury repair in the central nervous system and is characterized by the overexpression of the intermediate filaments (IFs) glial fibrillary acidic protein (GFAP) and vimentin...
  83. pmc Successive neuron loss in the thalamus and cortex in a mouse model of infantile neuronal ceroid lipofuscinosis
    Catherine Kielar
    Pediatric Storage Disorders Laboratory, Box P040, MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, King s College London, London, SE5 8AF, UK
    Neurobiol Dis 25:150-62. 2007
    ..These findings provide novel evidence for successive neuron loss within the thalamus and cortex in Ppt1-/- mice, revealing the thalamus as an important early focus of INCL pathogenesis...
  84. pmc Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model
    Caty Casas
    Department of Central Nervous System Alzheimer Disease, Aventis Pharma Paris Research Center, Vitry sur Seine, France
    Am J Pathol 165:1289-300. 2004
    ..Thus, APP(SL)PS1KI mice further confirm the critical role of intraneuronal Abeta(42) in neuronal loss and provide an excellent tool to investigate therapeutic strategies designed to prevent AD neurodegeneration...
  85. ncbi GFAP: functional implications gleaned from studies of genetically engineered mice
    Albee Messing
    Department of Pathobiological Sciences, Waisman Center and School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53705, USA
    Glia 43:87-90. 2003
    ..Here we review what the various GFAP mouse models reveal about GFAP and astrocyte function...
  86. ncbi Glia: the fulcrum of brain diseases
    C Giaume
    INSERM, U840 and Collège de France, Paris, France
    Cell Death Differ 14:1324-35. 2007
    ....
  87. ncbi Islet injury induces neurotrophin expression in pancreatic cells and reactive gliosis of peri-islet Schwann cells
    G Teitelman
    Department of Anatomy and Cell Biology, State University of New York Health Science Center at Brooklyn 11203, USA
    J Neurobiol 34:304-18. 1998
    ..These observations suggest that NGF could play an important role in pancreas during embryogenesis and in processes leading to repair following islet injury in adults...
  88. ncbi Signal transduction pathways regulating cyclooxygenase-2 in lipopolysaccharide-activated primary rat microglia
    Ravi Shankar Akundi
    Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    Glia 51:199-208. 2005
    ..This detailed view of the intracellular signaling pathway in microglial activation and COX-2 expression opens a new therapeutic window in the search for new and more effective central anti-inflammatory agents...
  89. pmc Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease
    Takashi Mori
    Department of Medical Science, Saitama Medical Center and University, Kawagoe, Saitama, Japan
    Glia 58:300-14. 2010
    ....
  90. ncbi Impaired glial glutamate transport in a mouse tuberous sclerosis epilepsy model
    Michael Wong
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Ann Neurol 54:251-6. 2003
    ..These findings suggest that Tsc1 inactivation in astrocytes causes dysfunctional glutamate homeostasis, leading to seizure development in TSC...
  91. ncbi Enriched environmental conditions reverse age-dependent gliosis and losses of neurofilaments and extracellular matrix components but do not alter lipofuscin accumulation in the hindlimb area of the aging rat brain
    Heidegard Hilbig
    Department of Medicine, Institute of Anatomy, Leipzig University, Liebigstr 13, D 04103 Leipzig, Germany
    J Chem Neuroanat 23:199-209. 2002
    ..With progressing age (12-36 months), a strong increase of lipofuscin and gliosis occurred in functionally characterized cortical areas, whereas a concomitant, area-specific loss of perineuronal ..
  92. ncbi Atypical gliosis in Müller cells of the slowly degenerating rds mutant mouse retina
    Ianors Iandiev
    Paul Flechsig Institut für Hirnforschung, Universitat Leipzig, Jahnallee 59, D 04109 Leipzig, Germany
    Exp Eye Res 82:449-57. 2006
    Retinal Müller glial cells are known to undergo reactive changes (gliosis) in various retinal diseases. In virtually all cases studied, an upregulation of glial fibrillary acidic protein (GFAP) and a hypertrophy can be observed...
  93. ncbi Subclinical photodynamic therapy treatment modifies the brain microenvironment and promotes glioma growth
    Ana C deCarvalho
    Departments of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan, USA
    Glia 55:1053-60. 2007
    ....
  94. ncbi Comparative evaluation of cytokine profiles and reactive gliosis supports a critical role for interleukin-6 in neuron-glia signaling during regeneration
    W J Streit
    Department of Neuroscience, University of Florida College of Medicine and Brain Institute, Gainesville 32611, Florida, USA
    J Neurosci Res 61:10-20. 2000
    ..Assessment of reactive glial changes with astroglial and microglial markers reveals that the reactive gliosis following adult facial nerve axotomy is more intense than that observed in either of the other two paradigms...
  95. pmc Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity
    Tamas L Horvath
    Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 107:14875-80. 2010
    ..Exposure to HFD was associated with reactive gliosis, and this affected the structure of the blood-brain barrier such that the POMC and NPY cell bodies and dendrites ..
  96. ncbi Alterations in protein expression and membrane properties during Müller cell gliosis in a murine model of transient retinal ischemia
    Petra G Hirrlinger
    Paul Flechsig Institut für Hirnforschung, Universitat Leipzig, Jahnallee 59, D 04109 Leipzig, Germany
    Neurosci Lett 472:73-8. 2010
    ..We found the typical indicators of reactive gliosis such as upregulation of glial fibrillary acidic protein...
  97. pmc Overexpression of human S100B exacerbates brain damage and periinfarct gliosis after permanent focal ischemia
    Takashi Mori
    Institute of Medical Science, Saitama Medical Center University, 1981 Kamoda, Kawagoe, Saitama 350 8550, Japan
    Stroke 39:2114-21. 2008
    ..Furthermore, we have suggested that the astrocyte-derived protein S100B may be important in these pathogenic events. However, the causal relationship between S100B and exacerbation of brain damage in vivo remains to be elucidated...
  98. ncbi Inhibiting cell cycle progression reduces reactive astrogliosis initiated by scratch injury in vitro and by cerebral ischemia in vivo
    Zhou Zhu
    Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Glia 55:546-58. 2007
    ....
  99. ncbi Astrocyte activation and apoptosis: their roles in the neuropathology of HIV infection
    Farideh Sabri
    Microbiology and Tumor Biology Center, Karolinska Institute, Nobels vag 16, S 17177 Stockholm, Sweden
    Brain Pathol 13:84-94. 2003
    ....
  100. ncbi Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease
    Ana I Rojo
    Centro de Investigación en Red sobre Enfermedades Neurodegenerativas, Spain
    Glia 58:588-98. 2010
    ..This study demonstrates a crucial role of Nrf2 in modulation of microglial dynamics and identifies Nrf2 as molecular target to control microglial function in Parkinson's disease (PD) progression...
  101. ncbi Reduction in CNS scar formation without concomitant increase in axon regeneration following treatment of adult rat brain with a combination of antibodies to TGFbeta1 and beta2
    L D Moon
    Physiological Department, University of Cambridge, Downing Site, Cambridge, CB2 3EG, UK
    Eur J Neurosci 14:1667-77. 2001
    ..b>Gliosis, inflammation and the response of dopaminergic nigral axons were assessed by immunolabelling...

Research Grants65

  1. Pathogenesis of Lyme Borreliosis in the Rhesus Monkey
    MARIO PHILIPP; Fiscal Year: 2007
    ..of inflammatory infiltrate (meninges), association of similar infiltrates present in brain specimens or areas of gliosis with foci of glial/neuronal apoptosis, and the overall correlation of such findings with presence of B...
  2. Epigenetic mechanisms relevant to the pathogenesis of ALS
    Neil W Kowall; Fiscal Year: 2013
    ..We found that spermidine treatment reduced neuronal loss and gliosis in G93A mice and restored LSD1 activity to normal levels...
  3. Mechanisms of virus-induced injury in the brain and spinal cord
    Kenneth L Tyler; Fiscal Year: 2013
    ..b>Gliosis (activation of microglia and astrocytes) is a hallmark of neuroinflammation...
  4. Neuroprotection by IFN-beta in AIDS
    Marcus Kaul; Fiscal Year: 2013
    ..Memory and cognition-based behavioral performance, neuronal injury, neurogenesis and gliosis will be compared in IFN?- versus vehicle-treated HIV/gp120-transgenic mice...
  5. Astrocyte Development and Reactive Gliosis
    Teri L Belecky-Adams; Fiscal Year: 2012
    ..sonic hedgehog (SHH), in increasing the development of a particularly detrimental cell state known as reactive gliosis. Reactive glia are present in many eye diseases, including glaucoma, age-related macular degeneration, retinitis ..
  6. BRAINSTEM MATURATION IN THE SUDDEN INFANT DEATH SYNDROME
    Hannah C Kinney; Fiscal Year: 2010
    ..We will determine if there is an abnormal number of neurons and reactive astrocytes (gliosis) in selected rhombic lip-derived nuclei in SIDS victims...
  7. Harness Germinal Matrix Hemorrhage
    John H Zhang; Fiscal Year: 2013
    ..Thrombin initiates inflammatory responses, gliosis and overproduction of extracellular matrix (ECM) proteins, which obstruct the cerebroventricular system and ..
  8. Neuroimmune modulation across the BBB: Regulation of ILS trafficking by TNF
    Weihong Pan; Fiscal Year: 2012
    ..endothelial IL15 system enhances TNF-induced neuroinflammation, shown by fever, sickness behavior, reactive gliosis, and cerebral production of proinflammatory cytokines...
  9. Chondroitin Sulfate Proteoglycan and Myelination in Intraventricular Hemorrhage
    Praveen Ballabh; Fiscal Year: 2010
    ..The most common white matter injury in premature infants is 'gliosis and hypomyelination with intact axons'...
  10. A multi-faceted approach to epigenomic profiling in Alzheimer's disorder
    Jonathan Mill; Fiscal Year: 2012
    ..e. differential cell death and gliosis) or the result of epigenomic changes in the remaining neurones...
  11. Cell Cycle Pathways and Spinal Cord Injury
    ALAN IRA FADEN; Fiscal Year: 2011
    ..It also likely contributes to post-traumatic gliosis and microglial activation...
  12. Imaging retinal astrocytes, ganglion cells and axonal transport in vivo
    Brad Fortune; Fiscal Year: 2012
    ..as ischemia, increased intraocular pressure and neuronal degeneration in a manner that has been characterized as gliosis. Hence, the ability to image astrocytes in vivo could help to elucidate aspects of disease pathophysiology...
  13. Defining a clinically relevant time point for astrocyte targeted therapy in ALS
    Brian K Kaspar; Fiscal Year: 2013
    ..The clinical and pathological presentation of both FALS and SALS is identical, in which striking gliosis, increase proliferation of astrocytes and microglia, occurs accompanied by selective MN cell death...
  14. Blood brain barrier immune compromise in NeuroAIDS
    Georgette D Kanmogne; Fiscal Year: 2012
    ..that Fludarabine, a specific STAT1 inhibitor, reduced inflammation and viral infectivity, reduced viremia, gliosis and macrophage infiltration in the brain of HIV encephalitic mice...
  15. Radiolabled MAO-B Substrates for Imaging
    Michael R Kilbourn; Fiscal Year: 2012
    ..is conspicuously expressed in astrocytes, and increased MAO-B enzymatic activity has been used as a biomarker of gliosis in numerous studies of diseases such as refractory epilepsy, Alzheimer's disease, amyotrophic lateral ..
  16. A Haplotype Map for Multiple Sclerosis
    Stephen L Hauser; Fiscal Year: 2013
    ..is a common and severe disorder of the central nervous system characterized by chronic inflammation, myelin loss, gliosis, varying degrees of axonal and oligodendrocyte pathology, and progressive neurological dysfunction...
  17. Pathogenesis of Chronic Wasting Disease in Transgenic Mice
    DAVIS MARTIN SEELIG; Fiscal Year: 2013
    ..mice will reveal novel, neuropathologic features of prion disease, including increased expression of markers of gliosis, neuronal loss and apoptosis adjacent to areas of PrPres accumulation...
  18. Generation of a Complement C3 Conditional Knockout Mouse
    Cynthia A Lemere; Fiscal Year: 2013
    ..Aged male C3KO mice have more synapses in hippocampus and cortex, neurons in CA3 of hippocampus, increased gliosis, and perform better in cognitive tests compared to WT mice...
  19. INTEGRINS AND OCULAR ANGIOGENESIS
    Martin Friedlander; Fiscal Year: 2013
    ..loss of vision do so as a result of abnormal angiogenesis and associated retinal edema, hemorrhage and gliosis. The research program supported by this grant for the past 15 years initially focused on understanding the role ..
  20. Effects of Methylmercury on Neuronal Cell Migration
    Hitoshi Komuro; Fiscal Year: 2010
    ..neuronal degeneration, abnormal arrangement of neurons in the cerebrum and cerebellum, and diffuse white matter gliosis in the brain of victims...
  21. Pathology-directed combination therapy for pediatric TBI
    Ramesh Raghupathi; Fiscal Year: 2013
    ..Although the pathologic alterations (cell death, axonal injury, reactive gliosis and inflammation) following closed head injury appears to be similar in both the mature and immature brains, ..
  22. New Strategy to Fight Selective Cholinergic Neuronal Loss in Alzheimer Disease
    William Z Suo; Fiscal Year: 2013
    ..GRK5 deficiency also exaggerates Ass accumulation and gliosis. Mechanistically, all phenotypes of GRK5 deficiency appear to be attributable to an impaired desensitization of ..
  23. NEUROPATHOLOGY OF CHRONIC MANGANESE EXPOSURE
    Brad A Racette; Fiscal Year: 2010
    ..In addition, the number of neurons and the extent of gliosis or other markers of injury in miners exposed to Mn will be correlated with the reconstructed occupational Mn ..
  24. Peripheral TGF-beta Pathway Inhibitor Therapy in Alzheimer's Rats
    Terrence Town; Fiscal Year: 2013
    ..Strikingly, TgF344-AD rats manifest age-dependent cerebral amyloidosis that precedes gliosis, tauopathy, neuronal loss and cognitive disturbance...
  25. CD200 as a monocyte/macrophage switch for brain repair after stroke
    Kazuhide Hayakawa; Fiscal Year: 2013
    ..with CD200Fc may increase CD34+/Flk1+ cells and TLR4low/Flk1high M-theta in parallel with reducing massive gliosis and improving neuronal plasticity in peri-infarct cortex after cerebral ischemia in mice...
  26. Combined Therapy for Intracerebral Hemorrhage Treatment
    Kenneth R Wagner; Fiscal Year: 2013
    ..will attenuate these molecular responses and will protect white matter by reducing demyelination, axonal injury, gliosis and cavitation...
  27. White matter injury in germinal matrix hemorrhage
    Praveen Ballabh; Fiscal Year: 2013
    ..The most common white matter injury in these infants is "hypomyelination and gliosis". Treatment and prevention of both the IVH and the resultant white matter damage is non-existent...
  28. Regulation of B-catenin by RPTPB/Z in fetal human glial progenitors
    Crystal R McClain; Fiscal Year: 2012
    ..a physiologically-relevant human cell system, into a broad category of neurological diseases that share reactive gliosis and aborted remyelination as key impediments to recovery...
  29. The involvement of Adapt78 in Alzheimer's disease and Down Syndrome
    Dana R Crawford; Fiscal Year: 2010
    ..Morphologically, neurodegeneration, apoptosis, gliosis and Adapt78 aggregate formation will also be evaluated...
  30. Screening for APPNeo Inhibitors
    Varghese John; Fiscal Year: 2013
    ..synapse loss, the brain atrophy (shrinkage), the electrophysiological abnormalities, and the brain scarring (gliosis)...
  31. Altered phosphorylation of connexin 43 contributes to increased gap-junction coup
    HEIDI GRABENSTATTER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pilocarpine-induced status epileptics (SE) induce reactive gliosis and activate calcium signaling in astrocytes of the hippocampus in a time-dependent manner (1, 2)...
  32. MicroRNAs for therapy of visual disorders
    Martin Friedlander; Fiscal Year: 2013
    ..loss of vision do so as a result of abnormal angiogenesis and associated retinal edema, hemorrhage and gliosis. Current anti-angiogenic strategies used in the clinics to treat complications of neovascularization in diseases ..
  33. Role of Cell Cycle in Neurodegeneration
    Hyoung gon Lee; Fiscal Year: 2012
    ..leads to accumulation of intraneuronal AB;4) results in a "neurodegenerative" (TUNEL) Phenotype;5) leads to gliosis;and 6) causes major cognitive deficits (Y- maze and MWM)...
  34. Gamma-ketoaldehydes in epileptogenesis
    L Jackson Roberts; Fiscal Year: 2013
    ..seizures associated with epileptogenesis and 4) determine if SA can inhibit neuronal death and/or reactive gliosis associated with epileptogenesis...
  35. Role of Extracellular Matrix in Retinal Development and Disease
    William J Brunken; Fiscal Year: 2012
    ..and the molecular mechanisms they reveal will contribute to our understanding of the pathophysiology of gliosis;proliferative vitreoretinopathy and congenital ocular disorders including Walker-Warburg, Bardet-Biedl, Pierson ..
  36. Immunogenetic Studies in Multiple Sclerosis
    Jorge R Oksenberg; Fiscal Year: 2013
    ..is a common and severe disorder of the central nervous system characterized by chronic inflammation, myelin loss, gliosis, varying degrees of axonal and oligodendrocyte pathology, and progressive neurological dysfunction...
  37. IN VIVO CHEMICAL MONITORING USING CAPILLARY SEPARATIONS
    Robert T Kennedy; Fiscal Year: 2013
    ..Long term monitoring is typically prevented by reactive gliosis, a tissue reaction that results in encapsulation of the probe and prevents sampling from active neural tissue...
  38. Impact of 18F-FDOPA-PET on neurosurgery and radiotherapy of glioma patients
    Nadia N Laack; Fiscal Year: 2013
    ..is difficult in this region due to the non-specific nature of T2 signal abnormalities which can also include gliosis and peri-tumoral edema...
  39. A Neurolucida and Stereo Investigator Imaging System with MicroLucida
    Frank M LaFerla; Fiscal Year: 2012
    ..volume loss and expansion of the ventricular spaces, dysregulated neurogenesis, and rampant neuroinflammation, gliosis, and scarring...
  40. Epidemiology of Aging and Dementia-Autopsy Research
    LON RAY WHITE; Fiscal Year: 2010
    ..Abnormalities identified in the remaining demented decedents (23%) were limited to generalized atrophy, gliosis, and neuron loss - not implicating a specific pathogenic mechanism...
  41. The Effects of Alcohol on JNK Mediated Inflammatory Signaling in Glial Cells
    Jack L Leonard; Fiscal Year: 2013
    ..in vivo, using experimental autoimmune encephalomyelitis (EAE), and lysophosphatidic acid induced reactive gliosis as model diseases...
  42. Targeting Muller Cells to Treat Optic Nerve Injury
    Sherry Ball; Fiscal Year: 2009
    ..Tissue will be collected at the end of the study to identify signaling mechanisms involved in reactive gliosis and subsequent cellular events...
  43. The role of FGF signaling in suppressing astrogliosis
    Jean M Hebert; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Gliosis is a response to brain damage and is a prominent feature of many neurological disorders including epilepsy, neurodegeneration, tumor growth, stroke, and trauma...
  44. GENE LINKAGE STUDY OF MULTIPLE SCLEROSIS SIBLING PAIRS
    Jorge R Oksenberg; Fiscal Year: 2013
    ..is a common and severe disorder of the central nervous system characterized by chronic inflammation, myelin loss, gliosis, varying degrees of axonal and oligodendrocyte pathology, and progressive neurological dysfunction...
  45. Cajal-Retzius Cells and Neuronal Signaling in Postnatal Cortical Networks
    Gianmaria Maccaferri; Fiscal Year: 2013
    ..Thus, new seizures would be produced, and additional reactive gliosis would maintain or even increase the available levels of SDF-1, restarting the pathological loop...
  46. HIV-1 gp120-mediated injury in brain endothelium
    Shalom Avraham; Fiscal Year: 2009
    ..Neuropathological disorders in AIDS patients have been associated with perivascular HIV-infected macrophages, gliosis and abnormalities in the permeability of the BBB...
  47. The Identification of Risk Factors for the Complex MS Phenotype
    Lisa F Barcellos; Fiscal Year: 2012
    ..complex and heterogeneous inflammatory disorder of the central nervous system (CNS) characterized by myelin loss, gliosis, varying degrees of axonal pathology, and progressive neurological dysfunction...
  48. MR Metabolic Markers for Evaluation of Patients with Recurrent Glioma
    Sarah J Nelson; Fiscal Year: 2013
    ..there is ambiguity between morphological changes that are caused by recurrent tumor and treatment effects such as gliosis and edema...
  49. Non-Invasive Quantitation of Cellular and Biochemical Changes in Hereditary Ataxi
    GULIN OZ; Fiscal Year: 2009
    ..This application focuses on two processes common to many neurodegenerative diseases, gliosis and oxidative stress...
  50. Evaluation of Neuroprotective Effects of AEOL10150 against Chemical Threat Agents
    Manisha N Patel; Fiscal Year: 2012
    ..is predicted to blunt oxidative stress and thereby prevent downstream changes such as metabolic dysfunction, gliosis and neuronal loss...
  51. Novel Bioactive Coatings for Chronically Implanted MEMS based Moveable Microelect
    Arati Sridharan; Fiscal Year: 2013
    ..to determine whether the crosslinking density and related stiffness of an encapsulating hydrogel will minimize gliosis and brain tissue damage and (2) to determine whether the combination of electrode movement and incorporation of ..
  52. A system approach to targeting innate immunity in AD
    Steven G Younkin; Fiscal Year: 2013
    ..by applicant): An invariant feature of the pathological cascade in Alzheimer's diseases (AD) is a reactive gliosis, reflecting an underlying alteration in the innate immune activation state within the brain...
  53. Elucidating the Role of VEGF-A in Pancreatic Islet Innervation
    Rachel B Reinert; Fiscal Year: 2010
    ..The second aim of this proposal will focus on the role of peri-islet Schwann cells, which undergo reactive gliosis in response to inactivation of pancreatic VEGF-A...
  54. NEW NEURONS IN THE RETINA
    Pamela A Raymond; Fiscal Year: 2010
    ..almost nothing is known about the molecular regulation that switches MOiler glia from a state of reactive gliosis to neurogenesis...
  55. Cellular Mechanisms of Fetal White Matter Injury
    STEPHEN ARTHUR BACK; Fiscal Year: 2013
    ..unexpected findings suggest the alternative overall hypothesis that myelination failure is related to diffuse gliosis and an arrest of OL maturation at pre-myelinating stages...
  56. PROPERTIES AND FUNCTION OF GLIA ION CHANNELS
    Harald W Sontheimer; Fiscal Year: 2011
    ..However, KCa expression and function can be re-acquired in glial cells following acute injury (gliosis) and in disease states in which glial migration is prominent...
  57. Muller glia and retina regeneration
    DANIEL J GOLDMAN; Fiscal Year: 2013
    ..In contrast, mammalian MG responds to retinal injury by reactive gliosis that is accompanied by hypertrophy;rarely do these cells re-enter the cell cycle and regenerate new neurons...
  58. A New Device for Electrical &Chemical Modulation of Pathological Neural Activity
    ROBERT SAMUEL LANGER; Fiscal Year: 2013
    ..Neuro-stimulatory electrodes have been shown to lose function over prolonged periods of implantation due to gliosis. Our proposed studies will develop a method for prolonging device function by retarding gliosis...
  59. MECHANISMS OF NEUROPATHOGENESIS IN BORNA DISEASE
    Mady Hornig; Fiscal Year: 2002
    ..While these models are intriguing they are associated with CNS inflammation, marked loss of brain mass and gliosis and may be less relevant to neuropsychiatric diseases than those in neonatally infected rats where BDV induces ..
  60. MULTIPLE-SCLEROSIS: A CD40 LIGAND ANTAGONIST
    Lloyd Kasper; Fiscal Year: 2005
    ..Multiple sclerosis (MS) is a clinical neurological disease characterized by chronic inflammation, demyelination and gliosis of the central nervous system...
  61. MULTIPLE-SCLEROSIS: A CD40 LIGAND ANTAGONIST
    Lloyd Kasper; Fiscal Year: 2003
    ..Multiple sclerosis (MS) is a clinical neurological disease characterized by chronic inflammation, demyelination and gliosis of the central nervous system...
  62. The Effects of Vitamin B3 on Traumatic Brain Injury
    MICHAEL HOANE; Fiscal Year: 2009
    ..g., neurodegeneration, edema formation and reactive gliosis)...
  63. NEURONAL DEVELOPMENT INTERACTION AND ORGANIZATION
    Michael Bennett; Fiscal Year: 2000
    ..The regulation of expression of connexins and their role in gliosis will be examined...
  64. KYNURENINES, GLIA AND EPILEPSY
    Robert Schwarcz; Fiscal Year: 2006
    Nerve cell death and gliosis in the limbic system are neuropathological hallmarks of temporal lobe epilepsy (TLE)...
  65. Carbon Nanotube Fibers as Implantable Neural Electrodes
    Douglas Adamson; Fiscal Year: 2009
    ..Currently available metal/silicon-based devices are not stable over the long term, mostly due to gliosis and inflammation...