gliosis

Summary

Summary: The production of a dense fibrous network of neuroglia; includes astrocytosis, which is a proliferation of astrocytes in the area of a degenerative lesion.

Top Publications

  1. ncbi Astrocyte activation and reactive gliosis
    Milos Pekny
    The Arvid Carlsson Institute for Neuroscience, Institute of Clinical Neuroscience, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Glia 50:427-34. 2005
  2. pmc Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: evidence against inflammation as a driving force for amyloid deposition
    Paramita Chakrabarty
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    FASEB J 24:548-59. 2010
  3. pmc Molecular dissection of reactive astrogliosis and glial scar formation
    Michael V Sofroniew
    Department of Neurobiology, University of California Los Angeles, Los Angeles, CA 90095 1763, USA
    Trends Neurosci 32:638-47. 2009
  4. doi Cellular signaling and factors involved in Müller cell gliosis: neuroprotective and detrimental effects
    Andreas Bringmann
    Department of Ophthalmology and Eye Hospital, University of Leipzig, Liebigstrasse 10 14, D 04103 Leipzig, Germany
    Prog Retin Eye Res 28:423-51. 2009
  5. doi The stem cell potential of glia: lessons from reactive gliosis
    Stefanie Robel
    Physiological Genomics, Ludwig Maximilians University of Munich, Germany
    Nat Rev Neurosci 12:88-104. 2011
  6. pmc Selective induction of astrocytic gliosis generates deficits in neuronal inhibition
    Pavel I Ortinski
    Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Nat Neurosci 13:584-91. 2010
  7. doi MAPK signal transduction underlying brain inflammation and gliosis as therapeutic target
    Bozena Kaminska
    Laboratory of Transcription Regulation, Nencki Institute of Experimental Biology, 3 Pasteur Str, Warsaw, Poland
    Anat Rec (Hoboken) 292:1902-13. 2009
  8. pmc Searching for neuropathology: gliosis in schizophrenia
    Tatiana P Schnieder
    Biopsychology and Behavioral Neuroscience Doctoral Program, City University of New York, New York, New York, USA
    Biol Psychiatry 69:134-9. 2011
  9. ncbi Mutant mice with small amounts of BubR1 display accelerated age-related gliosis
    Tyler K Hartman
    Department of Pediatric Adolescent Medicine, Mayo Clinic, College of Medicine, Rochester, MN 55905, United States
    Neurobiol Aging 28:921-7. 2007
  10. pmc Ciliary neurotrophic factor induces genes associated with inflammation and gliosis in the retina: a gene profiling study of flow-sorted, Müller cells
    Wei Xue
    Department of Ophthalmology, Northwestern University Feinberg Medical School, Chicago, Illinois, United States of America
    PLoS ONE 6:e20326. 2011

Research Grants

  1. Pathogenesis of Lyme Borreliosis in the Rhesus Monkey
    MARIO PHILIPP; Fiscal Year: 2007
  2. Model for Regulatiion of Gliosis in Glaucoma
    Philip Horner; Fiscal Year: 2007
  3. A Haplotype Map for Multiple Sclerosis
    Stephen L Hauser; Fiscal Year: 2010
  4. Effects of Methylmercury on Neuronal Cell Migration
    Hitoshi Komuro; Fiscal Year: 2010
  5. CELLULAR MECHANISMS OF RETINAL ANGIOGENESIS
    Robert William Caldwell; Fiscal Year: 2011
  6. CELLULAR MECHANISMS OF RETINAL ANGIOGENESIS
    RUTH B contact CALDWELL; Fiscal Year: 2010
  7. MECHANISMS OF NEUROPATHOGENESIS IN BORNA DISEASE
    Mady Hornig; Fiscal Year: 2002
  8. Control of retrovirus CNS disease by redox modulation
    Paul Wong; Fiscal Year: 2005
  9. MULTIPLE-SCLEROSIS: A CD40 LIGAND ANTAGONIST
    Lloyd Kasper; Fiscal Year: 2005
  10. Neuroimmune modulation across the BBB: Regulation of ILS trafficking by TNF
    Weihong Pan; Fiscal Year: 2010

Detail Information

Publications320 found, 100 shown here

  1. ncbi Astrocyte activation and reactive gliosis
    Milos Pekny
    The Arvid Carlsson Institute for Neuroscience, Institute of Clinical Neuroscience, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Glia 50:427-34. 2005
    ..The process of astrocyte activation remains rather enigmatic and results in so-called "reactive gliosis," a reaction with specific structural and functional characteristics...
  2. pmc Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: evidence against inflammation as a driving force for amyloid deposition
    Paramita Chakrabarty
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    FASEB J 24:548-59. 2010
    ..mIL-6 expression resulted in extensive gliosis and concurrently attenuated Abeta deposition in TgCRND8 mouse brains...
  3. pmc Molecular dissection of reactive astrogliosis and glial scar formation
    Michael V Sofroniew
    Department of Neurobiology, University of California Los Angeles, Los Angeles, CA 90095 1763, USA
    Trends Neurosci 32:638-47. 2009
    ..This article reviews developments in the signaling mechanisms that regulate specific aspects of reactive astrogliosis and highlights the potential to identify novel therapeutic molecular targets for diverse neurological disorders...
  4. doi Cellular signaling and factors involved in Müller cell gliosis: neuroprotective and detrimental effects
    Andreas Bringmann
    Department of Ophthalmology and Eye Hospital, University of Leipzig, Liebigstrasse 10 14, D 04103 Leipzig, Germany
    Prog Retin Eye Res 28:423-51. 2009
    ..However, Müller cell gliosis can also contribute to neurodegeneration and impedes regenerative processes in the retinal tissue by the ..
  5. doi The stem cell potential of glia: lessons from reactive gliosis
    Stefanie Robel
    Physiological Genomics, Ludwig Maximilians University of Munich, Germany
    Nat Rev Neurosci 12:88-104. 2011
    ..following brain injury, glia outside these niches acquire or reactivate stem cell potential as part of reactive gliosis. Recent studies have begun to uncover the molecular pathways involved in this process...
  6. pmc Selective induction of astrocytic gliosis generates deficits in neuronal inhibition
    Pavel I Ortinski
    Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Nat Neurosci 13:584-91. 2010
    ..Thus, reactive astrocytosis could generate local synaptic perturbations, leading to broader functional deficits associated with neurologic disease...
  7. doi MAPK signal transduction underlying brain inflammation and gliosis as therapeutic target
    Bozena Kaminska
    Laboratory of Transcription Regulation, Nencki Institute of Experimental Biology, 3 Pasteur Str, Warsaw, Poland
    Anat Rec (Hoboken) 292:1902-13. 2009
    ..mechanisms of inflammatory signal transduction in neurological disorders and in in vitro models of inflammation/gliosis. Mitogen-activated protein kinases (MAPKs) are a family of serine/threonine protein kinases responsible for most ..
  8. pmc Searching for neuropathology: gliosis in schizophrenia
    Tatiana P Schnieder
    Biopsychology and Behavioral Neuroscience Doctoral Program, City University of New York, New York, New York, USA
    Biol Psychiatry 69:134-9. 2011
    ..A sufficiently large autopsy study, weighted toward younger subjects, could provide a definitive answer, which if positive could be a major step toward finding an underlying pathological process...
  9. ncbi Mutant mice with small amounts of BubR1 display accelerated age-related gliosis
    Tyler K Hartman
    Department of Pediatric Adolescent Medicine, Mayo Clinic, College of Medicine, Rochester, MN 55905, United States
    Neurobiol Aging 28:921-7. 2007
    ..Levels of both GFAP and CD11b further increased with age. Our results demonstrate that BubR1 acts to prevent cerebral gliosis of both astrocytes and microglial cells, and suggest a role for BubR1 in the aging process of the brain.
  10. pmc Ciliary neurotrophic factor induces genes associated with inflammation and gliosis in the retina: a gene profiling study of flow-sorted, Müller cells
    Wei Xue
    Department of Ophthalmology, Northwestern University Feinberg Medical School, Chicago, Illinois, United States of America
    PLoS ONE 6:e20326. 2011
    ..We have, therefore, examined gene expression dynamics of purified Müller (glial) cells exposed to CNTF in vivo...
  11. pmc The contribution of gliosis to diffusion tensor anisotropy and tractography following traumatic brain injury: validation in the rat using Fourier analysis of stained tissue sections
    Matthew D Budde
    Neuroscience Research Centre, Milwaukee, WI 53226, USA
    Brain 134:2248-60. 2011
    ..62, P = 0.04) with the coherent organization of reactive astrocytes (i.e. gliosis) and was not attributed to axons. By comparison, a decrease in white matter anisotropy (P < 0...
  12. ncbi Gliosis and brain remodeling after treatment of stroke in rats with marrow stromal cells
    Yi Li
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, MI 48202, USA
    Glia 49:407-17. 2005
    ..Brain tissue repair is an ongoing process with reactive gliosis, which persists for at least 4 months after stroke...
  13. doi Efficacy of Rho-kinase inhibition in promoting cell survival and reducing reactive gliosis in the rodent retina
    Aysegül Tura
    University Eye Hospital of the Center of Ophthalmology at the Eberhard Karls University of Tübingen, Tubingen, Germany
    Invest Ophthalmol Vis Sci 50:452-61. 2009
    ..To analyze the outcomes of Rho-kinase (ROCK) inhibition on retinal cell survival and glial reactivity under adverse conditions...
  14. ncbi The role of astrocytes and complement system in neural plasticity
    Milos Pekny
    Center for Brain Repair and Rehabilitation, Department of Clinical Neuroscience and Rehabilitation, Institute for Neuroscience and Physiology at Sahlgrenska Academy Göteborg University, 405 30 Goteborg, Sweden
    Int Rev Neurobiol 82:95-111. 2007
    ..neurotrauma, brain ischemia or neurodegenerative diseases, astrocytes become reactive (which is known as reactive gliosis) and this is accompanied by an altered expression of many genes...
  15. pmc Inhibition of reactive gliosis attenuates excitotoxicity-mediated death of retinal ganglion cells
    Bhagyalaxmi S Ganesh
    Eye Research Institute of Oakland University, Rochester, Minnesota, United States of America
    PLoS ONE 6:e18305. 2011
    Reactive gliosis is a hallmark of many retinal neurodegenerative conditions, including glaucoma...
  16. pmc Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's disease
    Alberto Serrano-Pozo
    Massachusetts General Hospital Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Am J Pathol 179:1373-84. 2011
    ..They also suggest that reactive glia might contribute to the ongoing neurodegeneration...
  17. pmc Activin A is essential for neurogenesis following neurodegeneration
    Andrea Abdipranoto-Cowley
    Neuroscience Program, The Garvan Institute of Medical Research, Sydney, Australia
    Stem Cells 27:1330-46. 2009
    ..normal adult hippocampus and also, following lipopolysaccharide administration, had a potent inhibitory effect on gliosis in vivo and on microglial proliferation in vivo and in vitro...
  18. pmc Mild hypothermia causes differential, time-dependent changes in cytokine expression and gliosis following endothelin-1-induced transient focal cerebral ischemia
    An Gaëlle Ceulemans
    Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neuroscience, Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels, Belgium
    J Neuroinflammation 8:60. 2011
    ..This study is the first to investigate whether this neuroprotection occurs through modulation of the neuroinflammatory response after stroke in a time-dependent manner...
  19. ncbi Axonal regeneration and lack of astrocytic gliosis in EphA4-deficient mice
    Yona Goldshmit
    Center for Neuroscience and School of Physiotherapy, University of Melbourne, Melbourne, Victoria 3010, Australia
    J Neurosci 24:10064-73. 2004
    ..EphA4 expression was upregulated on astrocytes at the lesion site in wild-type mice, whereas astrocytic gliosis and the glial scar were greatly reduced in lesioned EphA4-/- spinal cords...
  20. pmc Long-term gliosis and molecular changes in the cervical spinal cord of the rhesus monkey after traumatic brain injury
    Kumi Nagamoto-Combs
    Department of Anatomy and Cell Biology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58202, USA
    J Neurotrauma 27:565-85. 2010
    ..Taken together, these changes in the non-human primate spinal cord support a long-term trophic/tropic role for reactive microglia, in particular, during functional and structural recovery after TBI...
  21. ncbi Therapeutic approaches to inflammation in neurodegenerative disease
    Andis Klegeris
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia, Canada
    Curr Opin Neurol 20:351-7. 2007
    ..Here we review recent advances in our understanding of one such disorder, Parkinson's disease, in which anti-inflammatory drugs are now becoming a new therapeutic focus...
  22. pmc Human and mouse microglia express connexin36, and functional gap junctions are formed between rodent microglia and neurons
    K Dobrenis
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci Res 82:306-15. 2005
    ....
  23. ncbi beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity
    H Zheng
    Department of Genetics and Molecular Biology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Cell 81:525-31. 1995
    ..In addition, four out of six homozygous mice showed reactive gliosis at 14 weeks of age, suggesting an impaired neuronal function as a result of the APP-null mutation.
  24. doi Reduced retina microglial activation and improved optic nerve integrity with minocycline treatment in the DBA/2J mouse model of glaucoma
    Alejandra Bosco
    Department of Neurobiology, University of Utah, Salt Lake City, Utah 84132, USA
    Invest Ophthalmol Vis Sci 49:1437-46. 2008
    ..The authors investigated the potential contribution of retinal microglia activation to glaucoma progression in the DBA/2J chronic mouse glaucoma model...
  25. ncbi Ladostigil prevents gliosis, oxidative-nitrative stress and memory deficits induced by intracerebroventricular injection of streptozotocin in rats
    Shai Shoham
    Research Department, Herzog Hospital, Jerusalem, Israel
    Neuropharmacology 52:836-43. 2007
    ..Taken together the data support the role of glial activation and oxidative-nitrative stress in discrete brain areas in the aetiology of memory deficits and indicate a potential mechanism for their prevention by drug treatment...
  26. pmc IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in rats
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Pain 135:232-9. 2008
    ..05) and inhibited NR1 phosphorylation compared to saline control. The results suggest that spinal IL-1beta is produced by astrocytes and enhances NR1 phosphorylation to facilitate inflammatory pain...
  27. pmc Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity
    Tamas L Horvath
    Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 107:14875-80. 2010
    ..Exposure to HFD was associated with reactive gliosis, and this affected the structure of the blood-brain barrier such that the POMC and NPY cell bodies and dendrites ..
  28. pmc Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain
    Annalisa Buffo
    Institute for Stem Cell Research, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstadter Landstrasse 1, 85764 Neuherberg Munich, Germany
    Proc Natl Acad Sci U S A 105:3581-6. 2008
    Reactive gliosis is the universal reaction to brain injury, but the precise origin and subsequent fate of the glial cells reacting to injury are unknown...
  29. pmc Egr-1 regulates expression of the glial scar component phosphacan in astrocytes after experimental stroke
    Heike Beck
    Institute for Clinical Molecular Biology and Tumor Genetics, German Research Center for Environmental Health, Helmholtz Center Munich, Munich, Germany
    Am J Pathol 173:77-92. 2008
    ..The process of gliosis has been well described, but the mechanisms regulating the robust production of scar components after injury ..
  30. ncbi Reactive nonproliferative gliosis predominates in a chronic mouse model of glaucoma
    D M Inman
    Department of Neurosurgery, University of Washington, Seattle, Washington 98104, USA
    Glia 55:942-53. 2007
    In many CNS diseases, proliferation becomes dysregulated; cells divide and participate in pathological processes. Gliosis is a fundamental CNS response to trauma or disease in which cell hypertrophy and proliferation play prominent roles...
  31. ncbi Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury
    Kristina A Kigerl
    Integrated Biomedical Science Graduate Program, College of Medicine, Ohio State University, Columbus, Ohio, USA
    J Neurochem 102:37-50. 2007
    ..Together, these data suggest that in the absence of pathogens, TLR2 and TLR4 are important for coordinating post-injury sequelae and perhaps in regulating inflammation and gliosis after SCI.
  32. pmc BMPR1a and BMPR1b signaling exert opposing effects on gliosis after spinal cord injury
    Vibhu Sahni
    Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 30:1839-55. 2010
    ..We investigated the role of bone morphogenetic protein (BMP) signaling in gliosis after SCI and find that BMPR1a and BMPR1b signaling exerts opposing effects on hypertrophy...
  33. ncbi Regeneration beyond the glial scar
    Jerry Silver
    Department of Neurosciences, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
    Nat Rev Neurosci 5:146-56. 2004
  34. pmc Endothelin-1 regulates astrocyte proliferation and reactive gliosis via a JNK/c-Jun signaling pathway
    Ana Gadea
    Center for Neuroscience Research, Children s National Medical Center, Washington, DC 20010, USA
    J Neurosci 28:2394-408. 2008
    Reactive gliosis is characterized by enhanced glial fibrillary acidic protein (GFAP) expression, cellular hypertrophy, and astrocyte proliferation. The cellular and molecular mechanisms underlying this process are still largely undefined...
  35. ncbi Bmi1 loss produces an increase in astroglial cells and a decrease in neural stem cell population and proliferation
    Dusan Zencak
    Jules Gonin Eye Hospital, Department of Ophthalmology, Lausanne University Medical School, 1004 Lausanne, Switzerland
    J Neurosci 25:5774-83. 2005
    ..Bmi1(-/-) mice also presented more astrocytes at birth, and a generalized gliosis at postnatal day 30...
  36. ncbi Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain
    M Ingelsson
    Harvard Medical School, Massachusetts General Hospital, Boston
    Neurology 62:925-31. 2004
    ..Pathologic changes in the Alzheimer disease (AD) brain occur in a hierarchical neuroanatomical pattern affecting cortical, subcortical, and limbic regions...
  37. pmc A new in vitro model of the glial scar inhibits axon growth
    Ina B Wanner
    Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, USA
    Glia 56:1691-709. 2008
    ..c) 2008 Wiley-Liss, Inc...
  38. ncbi Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS
    Thomas W Gould
    Department of Neurobiology and Anatomy and Program in Neuroscience, Wake Forest University, Winston Salem, North Carolina 27157 1010, USA
    J Neurosci 26:8774-86. 2006
    ..Furthermore, they suggest a novel, cell death-independent role for Bax in facilitating mutant SOD1-mediated motor denervation...
  39. doi Transient inflammation in neurogenic regions after irradiation of the developing brain
    Marie Kalm
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
    Radiat Res 171:66-76. 2009
    ..It remains to be elucidated whether these transient changes are involved in the persistent effects of radiation observed on neurogenesis and cognition in rodents...
  40. pmc Determining the threshold for alcohol-induced brain damage: new evidence with gliosis markers
    Dayna M Hayes
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536 0596, USA
    Alcohol Clin Exp Res 37:425-34. 2013
    ..Little is known about the threshold of the damaging effects of alcohol. Therefore, these experiments sought to determine a threshold for brain damage using various markers of neurodegeneration...
  41. doi Stab wound injury of the zebrafish telencephalon: a model for comparative analysis of reactive gliosis
    Emily Violette Baumgart
    Institute for Stem Cell Research, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
    Glia 60:343-57. 2012
    ..Invasive injury in the adult zebrafish telencephalon may therefore provide a useful model to untangle the molecular mechanisms involved in these beneficial glial reactions...
  42. pmc Ablation of neurons expressing agouti-related protein activates fos and gliosis in postsynaptic target regions
    Qi Wu
    Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 28:9218-26. 2008
    ..Furthermore, glial cell activation in target areas of AgRP neurons appears to be a result of excitotoxicity...
  43. ncbi Beneficial effects of alpha-lipoic acid plus vitamin E on neurological deficit, reactive gliosis and neuronal remodeling in the penumbra of the ischemic rat brain
    O Gonzalez-Perez
    Division de Neurociencias, Centro de Investigación Biomédica de Occidente CIBO del Instituto Mexicano del Seguro Social IMSS, Sierra Mojada 800, Guadalajara Jalisco 44340, Mexico
    Neurosci Lett 321:100-4. 2002
    ..The beneficial effects of this antioxidant mixture suggest that it may be valuable for the treatment of cerebral ischemia in humans...
  44. pmc Withaferin A targets intermediate filaments glial fibrillary acidic protein and vimentin in a model of retinal gliosis
    Paola Bargagna-Mohan
    Departmentsof Ophthalmology and Visual Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 285:7657-69. 2010
    b>Gliosis is a biological process that occurs during injury repair in the central nervous system and is characterized by the overexpression of the intermediate filaments (IFs) glial fibrillary acidic protein (GFAP) and vimentin...
  45. ncbi Microglia activation influences dye coupling and Cx43 expression of the astrocytic network
    Pedro M Faustmann
    Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Bochum, Germany
    Glia 42:101-8. 2003
    ....
  46. pmc Successive neuron loss in the thalamus and cortex in a mouse model of infantile neuronal ceroid lipofuscinosis
    Catherine Kielar
    Pediatric Storage Disorders Laboratory, Box P040, MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, King s College London, London, SE5 8AF, UK
    Neurobiol Dis 25:150-62. 2007
    ..These findings provide novel evidence for successive neuron loss within the thalamus and cortex in Ppt1-/- mice, revealing the thalamus as an important early focus of INCL pathogenesis...
  47. doi Nrf2 deficiency potentiates methamphetamine-induced dopaminergic axonal damage and gliosis in the striatum
    Noelia Granado
    Instituto Cajal, CSIC, Madrid, Spain
    Glia 59:1850-63. 2011
    Oxidative stress that correlates with damage to nigrostriatal dopaminergic neurons and reactive gliosis in the basal ganglia is a hallmark of methamphetamine (METH) toxicity...
  48. pmc AAV1/2-mediated CNS gene delivery of dominant-negative CCL2 mutant suppresses gliosis, beta-amyloidosis, and learning impairment of APP/PS1 mice
    Tomomi Kiyota
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    Mol Ther 17:803-9. 2009
    ..Our data support the idea that the AAV1/2 system is a useful tool for CNS gene delivery, and suppression of CCL2 may be a therapeutic target for the amelioration of AD-related neuroinflammation...
  49. pmc PEX13 deficiency in mouse brain as a model of Zellweger syndrome: abnormal cerebellum formation, reactive gliosis and oxidative stress
    C Catharina Müller
    Eskitis Institute for Cell and Molecular Therapies, and School of Biomolecular and Physical Sciences, Griffith University, Nathan, Brisbane, Queensland 4111, Australia
    Dis Model Mech 4:104-19. 2011
    ..Thus, PEX13-deficient mice provide a valuable animal model for investigating the molecular basis and treatment of ZS cerebellar pathology...
  50. doi Upregulation of EphA4 on astrocytes potentially mediates astrocytic gliosis after cortical lesion in the marmoset monkey
    Yona Goldshmit
    Australian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia
    J Neurotrauma 27:1321-32. 2010
    ..These results in a nonhuman primate model highlight the importance of developing pharmacotherapeutic approaches to block these molecules following brain injury...
  51. ncbi Effects of high cholesterol diet on gliosis in apolipoprotein E knockout mice. Implications for Alzheimer's disease and stroke
    M Crisby
    Neurotec Department, Divisions of Clinical and Experimental Geriatrics, Karolinska University Hospital Huddinge, Karolinska Institutet, SE 141 86 Stockholm, Sweden
    Neurosci Lett 369:87-92. 2004
    ..The long time exposure to HC diet combined with apoE deficiency resulted in a synergistic effect on the expression of NQO1 in the brain...
  52. ncbi Control of Müller glial cell proliferation and activation following retinal injury
    M A Dyer
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Neurosci 3:873-80. 2000
    ..Following neuronal damage, Müller cells undergo reactive gliosis, which is characterized by proliferation and changes in gene expression...
  53. doi Cognitive decline following major surgery is associated with gliosis, β-amyloid accumulation, and τ phosphorylation in old mice
    Yanjie Wan
    Department of Anesthesiology, Gongli Hospital, Pudong, Shanghai, China
    Crit Care Med 38:2190-8. 2010
    ..We sought to determine whether postoperative cognitive dysfunction in old mice is associated with the pathogenesis of Alzheimer's disease...
  54. doi Alterations in protein expression and membrane properties during Müller cell gliosis in a murine model of transient retinal ischemia
    Petra G Hirrlinger
    Paul Flechsig Institut für Hirnforschung, Universitat Leipzig, Jahnallee 59, D 04109 Leipzig, Germany
    Neurosci Lett 472:73-8. 2010
    ..We found the typical indicators of reactive gliosis such as upregulation of glial fibrillary acidic protein...
  55. pmc Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease
    Takashi Mori
    Department of Medical Science, Saitama Medical Center and University, Kawagoe, Saitama, Japan
    Glia 58:300-14. 2010
    ....
  56. pmc Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model
    Caty Casas
    Department of Central Nervous System Alzheimer Disease, Aventis Pharma Paris Research Center, Vitry sur Seine, France
    Am J Pathol 165:1289-300. 2004
    ..Thus, APP(SL)PS1KI mice further confirm the critical role of intraneuronal Abeta(42) in neuronal loss and provide an excellent tool to investigate therapeutic strategies designed to prevent AD neurodegeneration...
  57. ncbi Islet injury induces neurotrophin expression in pancreatic cells and reactive gliosis of peri-islet Schwann cells
    G Teitelman
    Department of Anatomy and Cell Biology, State University of New York Health Science Center at Brooklyn 11203, USA
    J Neurobiol 34:304-18. 1998
    ..These observations suggest that NGF could play an important role in pancreas during embryogenesis and in processes leading to repair following islet injury in adults...
  58. ncbi Signal transduction pathways regulating cyclooxygenase-2 in lipopolysaccharide-activated primary rat microglia
    Ravi Shankar Akundi
    Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    Glia 51:199-208. 2005
    ..This detailed view of the intracellular signaling pathway in microglial activation and COX-2 expression opens a new therapeutic window in the search for new and more effective central anti-inflammatory agents...
  59. ncbi Impaired glial glutamate transport in a mouse tuberous sclerosis epilepsy model
    Michael Wong
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Ann Neurol 54:251-6. 2003
    ..These findings suggest that Tsc1 inactivation in astrocytes causes dysfunctional glutamate homeostasis, leading to seizure development in TSC...
  60. ncbi GFAP: functional implications gleaned from studies of genetically engineered mice
    Albee Messing
    Department of Pathobiological Sciences, Waisman Center and School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53705, USA
    Glia 43:87-90. 2003
    ..Here we review what the various GFAP mouse models reveal about GFAP and astrocyte function...
  61. ncbi Glia: the fulcrum of brain diseases
    C Giaume
    INSERM, U840 and Collège de France, Paris, France
    Cell Death Differ 14:1324-35. 2007
    ....
  62. ncbi Subclinical photodynamic therapy treatment modifies the brain microenvironment and promotes glioma growth
    Ana C deCarvalho
    Departments of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan, USA
    Glia 55:1053-60. 2007
    ....
  63. ncbi Enriched environmental conditions reverse age-dependent gliosis and losses of neurofilaments and extracellular matrix components but do not alter lipofuscin accumulation in the hindlimb area of the aging rat brain
    Heidegard Hilbig
    Department of Medicine, Institute of Anatomy, Leipzig University, Liebigstr 13, D 04103 Leipzig, Germany
    J Chem Neuroanat 23:199-209. 2002
    ..With progressing age (12-36 months), a strong increase of lipofuscin and gliosis occurred in functionally characterized cortical areas, whereas a concomitant, area-specific loss of perineuronal ..
  64. ncbi Atypical gliosis in Müller cells of the slowly degenerating rds mutant mouse retina
    Ianors Iandiev
    Paul Flechsig Institut für Hirnforschung, Universitat Leipzig, Jahnallee 59, D 04109 Leipzig, Germany
    Exp Eye Res 82:449-57. 2006
    Retinal Müller glial cells are known to undergo reactive changes (gliosis) in various retinal diseases. In virtually all cases studied, an upregulation of glial fibrillary acidic protein (GFAP) and a hypertrophy can be observed...
  65. doi Regional differences between grey and white matter in cuprizone induced demyelination
    Viktoria Gudi
    Department of Neurology, Hannover Medical School, Hannover, Germany
    Brain Res 1283:127-38. 2009
    ..The time course and dynamics of demyelination differ in the corpus callosum and in the cortex, suggesting different underlying pathomechanisms...
  66. doi Uncoupling of neurodegeneration and gliosis in a murine model of juvenile cortical lesion
    Derya Sargin
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Goettingen 37075, Germany
    Glia 57:693-702. 2009
    ..Although the detailed mechanisms remain to be defined, these profound EPO effects open new ways for prophylaxis and therapy of neuropsychiatric diseases, e.g. schizophrenia...
  67. doi Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease
    Ana I Rojo
    Centro de Investigación en Red sobre Enfermedades Neurodegenerativas, Spain
    Glia 58:588-98. 2010
    ..This study demonstrates a crucial role of Nrf2 in modulation of microglial dynamics and identifies Nrf2 as molecular target to control microglial function in Parkinson's disease (PD) progression...
  68. ncbi Astrocyte activation and apoptosis: their roles in the neuropathology of HIV infection
    Farideh Sabri
    Microbiology and Tumor Biology Center, Karolinska Institute, Nobels vag 16, S 17177 Stockholm, Sweden
    Brain Pathol 13:84-94. 2003
    ....
  69. doi Microglial response to light-induced photoreceptor degeneration in the mouse retina
    Ana M Santos
    Departamento de Biologia Celular, Facultad de Ciencias, Universidad de Granada, E 18071 Granada, Spain
    J Comp Neurol 518:477-92. 2010
    ..The accumulation of activated microglial cells in affected regions simultaneously with photoreceptor degeneration suggests that they play some role in photodegeneration...
  70. ncbi Reduction in CNS scar formation without concomitant increase in axon regeneration following treatment of adult rat brain with a combination of antibodies to TGFbeta1 and beta2
    L D Moon
    Physiological Department, University of Cambridge, Downing Site, Cambridge, CB2 3EG, UK
    Eur J Neurosci 14:1667-77. 2001
    ..b>Gliosis, inflammation and the response of dopaminergic nigral axons were assessed by immunolabelling...
  71. ncbi Inhibiting cell cycle progression reduces reactive astrogliosis initiated by scratch injury in vitro and by cerebral ischemia in vivo
    Zhou Zhu
    Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Glia 55:546-58. 2007
    ....
  72. pmc Fibrosis and diseases of the eye
    Martin Friedlander
    Department of Cell Biology, The Scripps Research Institute, and Division of Ophthalmology, Scripps Clinic, La Jolla, CA 92037, USA
    J Clin Invest 117:576-86. 2007
    ..The recent development of progenitor and/or stem cell technologies holds promise for the treatment of currently incurable ocular diseases...
  73. ncbi Reactive microgliosis
    W J Streit
    Department of Neuroscience, University of Florida College of Medicine and Brain Institute, Gainesville 32610, USA
    Prog Neurobiol 57:563-81. 1999
    ....
  74. ncbi Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model
    Yasumasa Yoshiyama
    The Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuron 53:337-51. 2007
    ..Thus, hippocampal synaptic pathology and microgliosis may be the earliest manifestations of neurodegenerative tauopathies, and abrogation of tau-induced microglial activation could retard progression of these disorders...
  75. ncbi Identification of neuronal cell death in a model of degeneration in the hippocampus
    Ilker Y Eyupoglu
    Institute of Anatomy, Department of Cell and Neurobiology, Charité Campus Miffe, Humboldt University Medical School Charité, 10098 Berlin, Germany
    Brain Res Brain Res Protoc 11:1-8. 2003
    ..Treatment of microglial and BV-2 cells with an excess of L-glutamate induces cell death which could be detected by propidium iodide staining, but not by Fluoro-Jade, demonstrating its specificity to monitor neuronal cell death...
  76. ncbi Identification of second messengers that induce expression of functional gap junctions in microglia cultured from newborn rats
    Agustin D Martinez
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Brain Res 943:191-201. 2002
    ....
  77. ncbi Different aspects of gliosis in retinal Muller glia can be induced by CNTF, insulin, and FGF2 in the absence of damage
    Andy J Fischer
    Department of Neuroscience, Ohio State University, Columbus 43210, USA
    Mol Vis 10:973-86. 2004
    ..The purpose of this study was to assay whether growth factors influence the expression of filamentous proteins in Muller glia in the intact retinas of postnatal chickens...
  78. ncbi Comparative evaluation of cytokine profiles and reactive gliosis supports a critical role for interleukin-6 in neuron-glia signaling during regeneration
    W J Streit
    Department of Neuroscience, University of Florida College of Medicine and Brain Institute, Gainesville 32611, Florida, USA
    J Neurosci Res 61:10-20. 2000
    ..Assessment of reactive glial changes with astroglial and microglial markers reveals that the reactive gliosis following adult facial nerve axotomy is more intense than that observed in either of the other two paradigms...
  79. pmc Overexpression of human S100B exacerbates brain damage and periinfarct gliosis after permanent focal ischemia
    Takashi Mori
    Institute of Medical Science, Saitama Medical Center University, 1981 Kamoda, Kawagoe, Saitama 350 8550, Japan
    Stroke 39:2114-21. 2008
    ..Furthermore, we have suggested that the astrocyte-derived protein S100B may be important in these pathogenic events. However, the causal relationship between S100B and exacerbation of brain damage in vivo remains to be elucidated...
  80. ncbi Expression of S-100 protein is related to neuronal damage in MPTP-treated mice
    Yasuko Muramatsu
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan
    Glia 42:307-13. 2003
    ..These results provide valuable information for the pathogenesis of the acute stage of Parkinson's disease...
  81. doi Genetic fate mapping of Olig2 progenitors in the injured adult cerebral cortex reveals preferential differentiation into astrocytes
    Kouko Tatsumi
    The Department of Anatomy, Faculty of Medicine, Nara Medical University, Nara, Japan
    J Neurosci Res 86:3494-502. 2008
    ..These results suggest that reactive astrocytes, known to be the main contributors to glial scars, originate, at least in part, from Olig2(+) cells...
  82. pmc RET signaling does not modulate MPTP toxicity but is required for regeneration of dopaminergic axon terminals
    Sebastian Kowsky
    Department of Neurodegeneration and Restorative Research, Centers of Molecular Physiology of the Brain and Neurological Medicine, University of Goettingen, Waldweg 33, D 37073 Goettingen, Germany
    Proc Natl Acad Sci U S A 104:20049-54. 2007
    ..We therefore conclude that RET signaling has no influence on the survival of dopaminergic neurons in the MPTP model of Parkinson's disease but rather facilitates the regeneration of dopaminergic axon terminals...
  83. doi Blunted neurogenesis and gliosis due to transgenic overexpression of human soluble IL-1ra in the mouse
    Stefan Spulber
    Department of Neurobiology, Care Sciences and Society, Novum, Floor 5, Division of Neurodegeneration and Neuroinflammation, Karolinska Institutet, SE 141 86 Stockholm, Sweden
    Eur J Neurosci 27:549-58. 2008
    ..Taken together, our results indicate that IL-1 is crucial for the adaptability of the brain to acute and chronic neuroinflammation...
  84. ncbi Astroglial plasticity and glutamate function in a chronic mouse model of Parkinson's disease
    Adrian G Dervan
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Exp Neurol 190:145-56. 2004
    ..These results support reactive gliosis as a means of striatal compensation for dopamine loss...
  85. ncbi Role of glial K(+) channels in ontogeny and gliosis: a hypothesis based upon studies on Müller cells
    A Bringmann
    Department of Neurophysiology, Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany
    Glia 29:35-44. 2000
    ..individual types of K(+) channels undergo important changes in the course of ontogenetic development and during gliosis. Although immature Müller cells express inwardly rectifying K(+) (K(IR)) currents at a very low density, the ..
  86. ncbi Melatonin protects the central nervous system of rats against toluene-containing thinner intoxication by reducing reactive gliosis
    Giyasettin Baydas
    Department of Physiology, College of Medicine, Firat University, Elazig 23110, Turkey
    Toxicol Lett 137:169-74. 2003
    ..We also examined the protective effects of melatonin against gliosis. Western blots demonstrated a marked elevation in total GFAP, a specific marker for astrocytes, by thinner fume ..
  87. ncbi Quantitative immunochemistry on neuronal loss, reactive gliosis and BBB damage in cortex/striatum and hippocampus/amygdala after systemic kainic acid administration
    M Ding
    Department of Anatomy and Cell Biology, University of Goteborg, Sweden
    Neurochem Int 36:313-8. 2000
    ..Neuron specific enolase (NSE) reflects loss of neurons, glial fibrillary acidic protein (GFAP) reflects reactive gliosis, and brain levels of serum proteins measures blood-brain-barrier permeability...
  88. doi Absence of functional peroxisomes from mouse CNS causes dysmyelination and axon degeneration
    Leen Hulshagen
    Laboratory of Cell Metabolism, Department of Pharmaceutical Sciences, Katholieke Universiteit Leuven, Belgium
    J Neurosci 28:4015-27. 2008
    ..These anomalies of myelinated axons were already present in juvenile mice but aggravated in adulthood. Together, loss of CNS peroxisomal metabolism both affects myelin sheaths and axonal integrity possibly via independent pathways...
  89. doi Longitudinal in vivo imaging of retinal gliosis in a diabetic mouse model
    Saravana Kumar
    Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore
    Exp Eye Res 91:530-6. 2010
    In this study, we visualize and quantify retinal gliosis in vivo for monitoring early diabetic retinopathy (DR) in a transgenic mouse model...
  90. doi Autosomal dominant subcortical gliosis presenting as frontotemporal dementia
    R H Swerdlow
    University of Kansas School of Medicine, Landon Center on Aging, MS 2012, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Neurology 72:260-7. 2009
    To describe a multigenerational kindred with a frontotemporal dementia clinical syndrome (FTDS), extensive subcortical gliosis pathology, and autosomal dominant genetics.
  91. ncbi Energy substrate-supplemented resuscitation affects brain monocarboxylate transporter levels and gliosis in a rat model of hemorrhagic shock
    Tom Lin
    Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    J Trauma 59:1191-202; discussion 1202. 2005
    ..The hypothesis was that resuscitation with MC-based fluids would be accompanied by MCT1 up-regulation and glial response...
  92. ncbi Beta-amyloid and oxidative stress jointly induce neuronal death, amyloid deposits, gliosis, and memory impairment in the rat brain
    Laurent Lecanu
    Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20057, USA
    Pharmacology 76:19-33. 2006
    ..animals displayed thioflavin-S-positive amyloid deposits, hyperphosphorylated Tau protein, neuronal loss, and gliosis. Animals treated with Abeta42, Fe2+, or buthionine-sulfoximine alone or in combination failed to show the ..
  93. ncbi Continuous interleukin-6 application in vivo via macroencapsulation of interleukin-6-expressing COS-7 cells induces massive gliosis
    J Tilgner
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    Glia 35:234-45. 2001
    ..and microglia after 10 days by IL-6-secreting capsules, indicating that IL-6 is involved in the induction of gliosis. Control animals that received encapsulated mock-transfected COS-7 cells showed only a weak response...
  94. ncbi Reactive gliosis of immature Bergmann glia and microglial cell activation in response to cell death of granule cell precursors induced by methylazoxymethanol treatment in developing rat cerebellum
    M Lafarga
    Departamento de Anatomia y Biologia Celular, Facultad de Medicina, Santander, Spain
    Anat Embryol (Berl) 198:111-22. 1998
    ..Moreover, the presence of mitosis in this microglial population demonstrates its proliferative activity in regions of extensive cell death...
  95. ncbi Chemically induced neuronal damage and gliosis: enhanced expression of the proinflammatory chemokine, monocyte chemoattractant protein (MCP)-1, without a corresponding increase in proinflammatory cytokines(1)
    A R Little
    TMBB HELD, MS 3014, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505 2888, USA
    Neuroscience 115:307-20. 2002
    ..Administration of trimethyltin (TMT) to the rat results in loss of hippocampal neurons and an ensuing gliosis without BBB compromise...
  96. doi A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice
    Smita Saxena
    Friedrich Miescher Institut, Novartis Research Foundation, Basel, Switzerland
    Nat Neurosci 12:627-36. 2009
    ..Thus, whereas all motoneurons are preferentially affected in ALS, ER stress responses in specific motoneuron subtypes influence the progressive manifestations of weakening and paralysis...
  97. ncbi Hepatocyte growth factor (HGF) attenuates gliosis and motoneuronal degeneration in the brainstem motor nuclei of a transgenic mouse model of ALS
    Keiichi Kadoyama
    Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Osaka, Japan
    Neurosci Res 59:446-56. 2007
    ..These findings suggest that, in addition to direct neurotrophic activity on motoneurons, HGF-suppression of gliosis may retard disease progression, making HGF a potential therapeutic agent for the treatment of ALS patients.
  98. ncbi Massive retinal gliosis: a late complication of retinal detachment surgery
    Faik Gelisken
    Department of Ophthalmology 1, University Eye Clinic, Schleichstrasse 12, 72076 Tuebingen, Germany
    Graefes Arch Clin Exp Ophthalmol 242:255-8. 2004
    Massive retinal gliosis is a rare, benign, intraocular tumor. It develops mostly in long-standing ocular disease such as chronic inflammation, vascular disorders, glaucoma, trauma, or congenital abnormalities...
  99. doi Type I interferon inhibits astrocytic gliosis and promotes functional recovery after spinal cord injury by deactivation of the MEK/ERK pathway
    Motokazu Ito
    Department of Neurosurgery, Nagoya University School of Medicine, Nagoya, Japan
    J Neurotrauma 26:41-53. 2009
    ..First, we attempted to identify profile changes in the expression of astrocytic gliosis 10 days after injury by using gliosis-specific microdissection, genome-wide microarray, and MetaCore(trade mark) ..
  100. ncbi Ro5-4864, a peripheral benzodiazepine receptor ligand, reduces reactive gliosis and protects hippocampal hilar neurons from kainic acid excitotoxicity
    Sergio Veiga
    Instituto Cajal, C S I C, Madrid, Spain
    J Neurosci Res 80:129-37. 2005
    ..Administration of Ro5-4864, before the injection of kainic acid, decreased reactive gliosis in the hilus and prevented hilar neuronal loss...
  101. doi Hypothyroid state does not protect but delays neuronal death in the hippocampal CA1 region following transient cerebral ischemia: focus on oxidative stress and gliosis
    Choong Hyun Lee
    Department of Anatomy and Neurobiology and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University, Chuncheon 200 702, South Korea
    J Neurosci Res 88:2661-8. 2010
    We investigated protective effects of hypothyroidism on delayed neuronal death, gliosis, lipid peroxidation and Cu,Zn-superoxide dismutase (SOD1) in the gerbil hippocampal CA1 region (CA1) after 5 min of transient cerebral ischemia...

Research Grants85

  1. Pathogenesis of Lyme Borreliosis in the Rhesus Monkey
    MARIO PHILIPP; Fiscal Year: 2007
    ..of inflammatory infiltrate (meninges), association of similar infiltrates present in brain specimens or areas of gliosis with foci of glial/neuronal apoptosis, and the overall correlation of such findings with presence of B...
  2. Model for Regulatiion of Gliosis in Glaucoma
    Philip Horner; Fiscal Year: 2007
    ..Glial response to injury is called gliosis, and involves upregulation of intermediate filaments within the cell, changes in the complement of ion channels, ..
  3. A Haplotype Map for Multiple Sclerosis
    Stephen L Hauser; Fiscal Year: 2010
    ..is a common and severe disorder of the central nervous system characterized by chronic inflammation, myelin loss, gliosis, varying degrees of axonal and oligodendrocyte pathology, and progressive neurological dysfunction...
  4. Effects of Methylmercury on Neuronal Cell Migration
    Hitoshi Komuro; Fiscal Year: 2010
    ..neuronal degeneration, abnormal arrangement of neurons in the cerebrum and cerebellum, and diffuse white matter gliosis in the brain of victims...
  5. CELLULAR MECHANISMS OF RETINAL ANGIOGENESIS
    Robert William Caldwell; Fiscal Year: 2011
    ..Increasing arginase activity may also contribute to pathological retinal angiogenesis and fibrosis/gliosis by increasing formation of polyamines and proline, which induce cell growth and collagen production, respectively...
  6. CELLULAR MECHANISMS OF RETINAL ANGIOGENESIS
    RUTH B contact CALDWELL; Fiscal Year: 2010
    ..Increasing arginase activity may also contribute to pathological retinal angiogenesis and fibrosis/gliosis by increasing formation of polyamines and proline, which induce cell growth and collagen production, respectively...
  7. MECHANISMS OF NEUROPATHOGENESIS IN BORNA DISEASE
    Mady Hornig; Fiscal Year: 2002
    ..While these models are intriguing they are associated with CNS inflammation, marked loss of brain mass and gliosis and may be less relevant to neuropsychiatric diseases than those in neonatally infected rats where BDV induces ..
  8. Control of retrovirus CNS disease by redox modulation
    Paul Wong; Fiscal Year: 2005
    ..Infection in the central nervous system by tsl results in neuronal loss with gliosis and spongiform lesions...
  9. MULTIPLE-SCLEROSIS: A CD40 LIGAND ANTAGONIST
    Lloyd Kasper; Fiscal Year: 2005
    ..Multiple sclerosis (MS) is a clinical neurological disease characterized by chronic inflammation, demyelination and gliosis of the central nervous system...
  10. Neuroimmune modulation across the BBB: Regulation of ILS trafficking by TNF
    Weihong Pan; Fiscal Year: 2010
    ..endothelial IL15 system enhances TNF-induced neuroinflammation, shown by fever, sickness behavior, reactive gliosis, and cerebral production of proinflammatory cytokines...
  11. KYNURENINES, GLIA AND EPILEPSY
    Robert Schwarcz; Fiscal Year: 2006
    Nerve cell death and gliosis in the limbic system are neuropathological hallmarks of temporal lobe epilepsy (TLE)...
  12. Neuroprotection by IFN-beta in AIDS
    Marcus Kaul; Fiscal Year: 2010
    ..Memory and cognition-based behavioral performance, neuronal injury, neurogenesis and gliosis will be compared in IFN?- versus vehicle-treated HIV/gp120-transgenic mice...
  13. Astrocyte Development and Reactive Gliosis
    Teri L Belecky Adams; Fiscal Year: 2010
    ..sonic hedgehog (SHH), in increasing the development of a particularly detrimental cell state known as reactive gliosis. Reactive glia are present in many eye diseases, including glaucoma, age-related macular degeneration, retinitis ..
  14. CEREBRAL HEMORRHAGE MODEL--MECHANISMS AND TREATMENTS
    Kenneth Wagner; Fiscal Year: 1999
    ..This edema is prolonged and damages the white matter causing by demyelination and gliosis. Our preliminary studies show this edema develops 1) following plasma, but not packed red cell, infusions into ..
  15. INFLAMMATORY NEUROLOGICAL DISEASES
    Iain Campbell; Fiscal Year: 2001
    ..He will describe the developmental and anatomic distribution of IL12 expression in the CNS, the degree of gliosis, microglial density and myelin and oligodendroglial changes (if any)...
  16. Cell Cycle Pathways and Spinal Cord Injury
    ALAN FADEN; Fiscal Year: 2007
    ..It also likely contributes to post-traumatic gliosis and microglial activation...
  17. Carbon Nanotube Fibers as Implantable Neural Electrodes
    Douglas Adamson; Fiscal Year: 2009
    ..Currently available metal/silicon-based devices are not stable over the long term, mostly due to gliosis and inflammation...
  18. Carbon Nanotube Fibers as Implantable Neural Electrodes
    Douglas Adamson; Fiscal Year: 2007
    ..Currently available metal/silicon-based devices are not stable over the long term, mostly due to gliosis and inflammation...
  19. Immunogenetic Studies in Multiple Sclerosis
    Jorge R Oksenberg; Fiscal Year: 2010
    ..is a common and severe disorder of the central nervous system characterized by chronic inflammation, myelin loss, gliosis, varying degrees of axonal and oligodendrocyte pathology, and progressive neurological dysfunction...