diseases in twins

Summary

Summary: Disorders affecting TWINS, one or both, at any age.

Top Publications

  1. ncbi The Child and Adolescent Twin Study in Sweden (CATSS)
    Henrik Anckarsater
    Institute of Neuroscience and Physiology, Forensic Psychiatry, University of Gothenburg, Sweden
    Twin Res Hum Genet 14:495-508. 2011
  2. ncbi The Swedish Twin Registry: a unique resource for clinical, epidemiological and genetic studies
    P Lichtenstein
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 252:184-205. 2002
  3. ncbi Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins
    G Kuratomi
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Hirosawa, Wako, Saitama, Japan
    Mol Psychiatry 13:429-41. 2008
  4. pmc A developmental twin study of symptoms of anxiety and depression: evidence for genetic innovation and attenuation
    K S Kendler
    Virginia Institute of Psychiatric and Behavioral Genetics, Medical College of Virginia Virginia Commonwealth University, Richmond, VA, USA
    Psychol Med 38:1567-75. 2008
  5. ncbi The Swedish Twin Registry in the third millennium: an update
    Paul Lichtenstein
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Twin Res Hum Genet 9:875-82. 2006
  6. ncbi Recurrence of congenital heart defects in families
    Nina Øyen
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen S, Denmark
    Circulation 120:295-301. 2009
  7. ncbi A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorder
    Avshalom Caspi
    Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, England
    Arch Gen Psychiatry 65:203-10. 2008
  8. ncbi The role of genes and environment in shaping co-occurrence of DSM-IV defined anxiety dimensions among Italian twins aged 8-17
    Anna Ogliari
    The Academic Centre for the Study of Behavioural Plasticity, Vita Salute San Raffaele University, Milan, Italy
    J Anxiety Disord 24:433-9. 2010
  9. ncbi Population-based family studies in genetic epidemiology
    John L Hopper
    University of Melbourne, Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, 723 Swanston Street, Carlton, Victoria 3053, Australia
    Lancet 366:1397-406. 2005
  10. ncbi Comorbidity with low back pain: a cross-sectional population-based survey of 12- to 22-year-olds
    Lise Hestbaek
    Back Research Center, Ringe, Denmark
    Spine (Phila Pa 1976) 29:1483-91; discussion 1492. 2004

Research Grants

Detail Information

Publications267 found, 100 shown here

  1. ncbi The Child and Adolescent Twin Study in Sweden (CATSS)
    Henrik Anckarsater
    Institute of Neuroscience and Physiology, Forensic Psychiatry, University of Gothenburg, Sweden
    Twin Res Hum Genet 14:495-508. 2011
    ..The CATSS study has the potential of answering important questions on the etiology of childhood mental health problems and their role in the development of later adjustment problems...
  2. ncbi The Swedish Twin Registry: a unique resource for clinical, epidemiological and genetic studies
    P Lichtenstein
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 252:184-205. 2002
    ..In the following, we will summarize the content of the database, describe for the first time recent data collection efforts and review some of the principal findings that have come from the Registry...
  3. ncbi Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins
    G Kuratomi
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Hirosawa, Wako, Saitama, Japan
    Mol Psychiatry 13:429-41. 2008
    ..We found strong inverse correlation between gene expression and DNA methylation levels of PPIEL. These results suggest that altered DNA methylation statuses of PPIEL might have some significance in pathophysiology of bipolar disorder....
  4. pmc A developmental twin study of symptoms of anxiety and depression: evidence for genetic innovation and attenuation
    K S Kendler
    Virginia Institute of Psychiatric and Behavioral Genetics, Medical College of Virginia Virginia Commonwealth University, Richmond, VA, USA
    Psychol Med 38:1567-75. 2008
    ..Analysis conducted using the Mx program included SxAnxDep by parental and self-report...
  5. ncbi The Swedish Twin Registry in the third millennium: an update
    Paul Lichtenstein
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Twin Res Hum Genet 9:875-82. 2006
    ..In particular, we describe recent efforts to screen all twins born between 1959 and 1985, and young twin pairs when they turn 9 and 12 years of age. For these studies, we present initial frequencies of common conditions and exposures...
  6. ncbi Recurrence of congenital heart defects in families
    Nina Øyen
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen S, Denmark
    Circulation 120:295-301. 2009
    ..We estimated an individual's risk of CHD given a family history of CHD, as well as the contribution of CHD family history to the total number of CHD cases in the population...
  7. ncbi A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorder
    Avshalom Caspi
    Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, England
    Arch Gen Psychiatry 65:203-10. 2008
    ..Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous neurodevelopmental disorder that in some cases is accompanied by antisocial behavior...
  8. ncbi The role of genes and environment in shaping co-occurrence of DSM-IV defined anxiety dimensions among Italian twins aged 8-17
    Anna Ogliari
    The Academic Centre for the Study of Behavioural Plasticity, Vita Salute San Raffaele University, Milan, Italy
    J Anxiety Disord 24:433-9. 2010
    ....
  9. ncbi Population-based family studies in genetic epidemiology
    John L Hopper
    University of Melbourne, Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, 723 Swanston Street, Carlton, Victoria 3053, Australia
    Lancet 366:1397-406. 2005
    ..Given their versatility, population-based family studies could become a principal framework in epidemiology, and move genetics from its traditional focus on high-risk families to give it a wider clinical and population health relevance...
  10. ncbi Comorbidity with low back pain: a cross-sectional population-based survey of 12- to 22-year-olds
    Lise Hestbaek
    Back Research Center, Ringe, Denmark
    Spine (Phila Pa 1976) 29:1483-91; discussion 1492. 2004
    ..Cross-sectional, population-based survey...
  11. ncbi Discordant KCNQ1OT1 imprinting in sets of monozygotic twins discordant for Beckwith-Wiedemann syndrome
    Rosanna Weksberg
    Division of Clinical and Metabolic Genetics and the Research Institute, Department of Paediatrics Hospital for Sick Children, Toronto, Ontario, Canada
    Hum Mol Genet 11:1317-25. 2002
    ..These data underscore the importance of continued surveillance of children born following assisted reproductive technologies that impact the preimplantation embryo...
  12. ncbi The genetics of anorexia nervosa
    Cynthia M Bulik
    Department of Psychiatry, University of North Carolina at Chapel Hill, NC 27599, USA
    Annu Rev Nutr 27:263-75. 2007
    ..With these bodies of literature as a starting point, we evaluate critically the current state of research on molecular genetic studies of anorexia nervosa and provide guidance for future research...
  13. pmc Exploring the relationship between autistic-like traits and ADHD behaviors in early childhood: findings from a community twin study of 2-year-olds
    Angelica Ronald
    Centre for Brain and Cognitive Development, School of Psychology, Birkbeck College, Malet Street, London WC1E 7HX, UK
    J Abnorm Child Psychol 38:185-96. 2010
    ..27) as well as some common environmental influences explaining their covariation. Implications for identifying shared biological pathways underlying autistic-like traits and ADHD behaviors are discussed...
  14. pmc Alcohol consumption indices of genetic risk for alcohol dependence
    Julia D Grant
    Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biol Psychiatry 66:795-800. 2009
    ..A high genetic correlation between these measures would suggest that a continuous measure of consumption may have a useful role in the discovery of genes contributing to dependence risk...
  15. ncbi Genetic aspects of normal and disturbed sleep
    Mehdi Tafti
    Center for Integrative Genomics, University of Lausanne, Genopode, 1015 Lausanne, Switzerland
    Sleep Med 10:S17-21. 2009
    ....
  16. ncbi Life satisfaction and depression in a 15-year follow-up of healthy adults
    Heli Koivumaa-Honkanen
    Dept of Psychiatry 2700, Kuopio University Hospital, P O B 1777, 70211 Kuopio, Finland
    Soc Psychiatry Psychiatr Epidemiol 39:994-9. 2004
    ..The aim of this study was to investigate the cross-sectional and longitudinal relationship between life satisfaction and depressive symptoms in healthy adults...
  17. ncbi Sex differences in the genetic and environmental influences on the development of antisocial behavior
    Kristen C Jacobson
    Virginia Institute for Psychiatric and Behavioral Genetics, USA
    Dev Psychopathol 14:395-416. 2002
    ..We speculate that sex differences in timing of puberty may account for the earlier presence of genetic effects among females...
  18. ncbi A Swedish national twin study of lifetime major depression
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Am J Psychiatry 163:109-14. 2006
    ..It is not known whether genetic effects on major depression are constant across historical cohorts...
  19. pmc Stable genetic influence on anxiety-related behaviours across middle childhood
    Maciej Trzaskowski
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Box PO80, De Crespigny Park, London SE5 8AF, UK
    J Abnorm Child Psychol 40:85-94. 2012
    ..In contrast, though more varied, heterotypic continuity between some traits (i.e. the change from one type of anxiety-related behaviour into another over time) was mainly due to shared-environmental factors...
  20. ncbi Congenital heart disease in a population of dizygotic twins: an echocardiographic study
    Salvatore Caputo
    Pediatric Cardiology, Second University of Naples, Monaldi Hospital, Naples, Italy
    Int J Cardiol 102:293-6. 2005
    ..Dizygotic twins are siblings with different genes, growing together in the same womb...
  21. ncbi Prevalence, heritability, and prospective risk factors for anorexia nervosa
    Cynthia M Bulik
    Department of Psychiatry, School of Public Health, University of North Carolina at Chapel Hill, 27599, USA
    Arch Gen Psychiatry 63:305-12. 2006
    ..Anorexia nervosa (AN) is a serious mental illness with marked morbidity and mortality...
  22. ncbi The Autism--Tics, AD/HD and other Comorbidities (A-TAC) telephone interview: convergence with the Child Behavior Checklist (CBCL)
    Sara Lina Hansson Halleröd
    Department of Clinical Sciences, Malmo, Lund University, Sege Park 8A, SE 205 02 Malmo, Sweden
    Nord J Psychiatry 64:218-24. 2010
    ....
  23. pmc Adiposity is inversely related to insulin sensitivity in relatively lean Chinese adolescents: a population-based twin study
    Fengxiu Ouyang
    Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Am J Clin Nutr 91:662-71. 2010
    ..Adolescence is a critical period for rising adiposity and falling insulin sensitivity (IS), but the independent relation between adiposity and IS remains understudied...
  24. ncbi Genetic predisposition to organ-specific endpoints of alcoholism
    T Reed
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, USA
    Alcohol Clin Exp Res 20:1528-33. 1996
    ....
  25. ncbi Failure to confirm CNVs as of aetiological significance in twin pairs discordant for schizophrenia
    Shinji Ono
    Department of Human Genetics, Nagasaki University Graduate School of Biomedical Sciences, Japan
    Twin Res Hum Genet 13:455-60. 2010
    ..Schizophrenia caused by strong genetics factors including copy number alteration or gene mutation may be a small subset of the clinical population...
  26. pmc Influence of twin-twin transfusion syndrome on fetal cardiovascular structure and function: prospective case-control study of 136 monochorionic twin pregnancies
    A A Karatza
    Department of Maternal Fetal Medicine, Queen Charlotte s and Chelsea Hospital, Imperial College, London, UK
    Heart 88:271-7. 2002
    ..To test the hypothesis that identical twins show no inter-twin differences in cardiovascular structure or physiology in fetal life unless there has been twin-twin transfusion syndrome...
  27. ncbi Gray and white matter volume abnormalities in monozygotic and same-gender dizygotic twins discordant for schizophrenia
    Hilleke E Hulshoff Pol
    Rudolf Magnus Institute for Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 55:126-30. 2004
    ....
  28. ncbi Phenotypic and genetic differentiation of anxiety-related behaviors in middle childhood
    Victoria Hallett
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London, UK
    Depress Anxiety 26:316-24. 2009
    ..This study aimed to examine both the phenotypic and genetic differentiation of ARB subtypes within the general population at age 7 and 9. It constituted a follow-up to an earlier study of ARBs in preschool children...
  29. pmc Familial aggregation of amyotrophic lateral sclerosis
    Fang Fang
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Ann Neurol 66:94-9. 2009
    ..To assess the relative risk for amyotrophic lateral sclerosis (ALS) in families of ALS patients...
  30. ncbi A longitudinal study of personality and major depression in a population-based sample of male twins
    Ayman H Fanous
    Washington VA Medical Center, Washington, DC 20422, USA
    Psychol Med 37:1163-72. 2007
    ..The relationship between personality and psychiatric illness is complex. It is not clear whether one directly causes the other...
  31. pmc Gene expression in peripheral blood leukocytes in monozygotic twins discordant for chronic fatigue: no evidence of a biomarker
    Andrea Byrnes
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 4:e5805. 2009
    ..Chronic fatiguing illness remains a poorly understood syndrome of unknown pathogenesis. We attempted to identify biomarkers for chronic fatiguing illness using microarrays to query the transcriptome in peripheral blood leukocytes...
  32. ncbi The UK Adult Twin Registry (TwinsUK)
    Tim D Spector
    Twin Research and Genetic Epidemiology Unit, Kings College London, St Thomas Hospital Campus, London, UK
    Twin Res Hum Genet 9:899-906. 2006
    ..The resource has led to many successful and innovative research projects particularly in common age-related diseases, and has led to collaborations with over 80 groups worldwide...
  33. ncbi Attention-deficit/hyperactivity disorder: a selective overview
    Joseph Biederman
    Department of Pediatric Psychopharmacology Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Psychiatry 57:1215-20. 2005
    ..Such alterations in dopaminergic and noradrenergic function are apparently necessary for the clinical efficacy of pharmacologic treatments of ADHD...
  34. ncbi Genetic and environmental factors in complex diseases: the older Finnish Twin Cohort
    Jaakko Kaprio
    Dept of Public Health, University of Helsinki, National Public Health Institute, Helsinki, Finland
    Twin Res 5:358-65. 2002
    ..Finally, the inclusion of DNA-based genetic information in a phenotypically rich family data base will offer a unique resource for research in genetic epidemiology and behavioral medicine...
  35. ncbi The five-factor model of personality and borderline personality disorder: a genetic analysis of comorbidity
    Marijn A Distel
    Department of Biological Psychology, VU University Amsterdam, 1081 BT Amsterdam, The Netherlands
    Biol Psychiatry 66:1131-8. 2009
    ....
  36. pmc Genetic and environmental contributions to phenotypic components of metabolic syndrome: a population-based twin study
    Shanchun Zhang
    Mary Ann and J Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children s Memorial Hospital and Children s Memorial Research Center, Chicago, Illinois, USA
    Obesity (Silver Spring) 17:1581-7. 2009
    ..Our study underscores the importance of examining MS components as intercorrelated traits, and to carefully consider environmental and genetic factors in studying MS etiology...
  37. ncbi Boundaries of major depression: an evaluation of DSM-IV criteria
    K S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia of Virginia Commonwealth University, Richmond, USA
    Am J Psychiatry 155:172-7. 1998
    ..Little is known about the boundaries between major depression and milder subsyndromal depressive states. With respect to depressive symptoms, does DSM-IV "carve nature at its joints"?..
  38. ncbi Amygdala responses to emotional faces in twins discordant or concordant for the risk for anxiety and depression
    Saskia P A Wolfensberger
    Department of Psychiatry, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Neuroimage 41:544-52. 2008
    ..To account for these discrepant findings, we hypothesize that genetic and environmental risk factors differently impact on amygdala functioning...
  39. ncbi Epidemiology and course of anorexia nervosa in the community
    Anna Keski-Rahkonen
    Department of Epidemiology, Columbia University, New York, NY, USA
    Am J Psychiatry 164:1259-65. 2007
    ..The authors sought to describe the onset and outcomes of anorexia nervosa in the general population...
  40. ncbi Common genetic vulnerability for nicotine and alcohol dependence in men
    W R True
    School of Public Health, St Louis University Health Sciences Center, MO, USA
    Arch Gen Psychiatry 56:655-61. 1999
    ..We examined data from male twin pairs to determine whether there are genetic or environmental influences common to nicotine and alcohol dependence, and, if so, to estimate the magnitude and correlation of these influences...
  41. ncbi Incidence and outcomes of bulimia nervosa: a nationwide population-based study
    A Keski-Rahkonen
    Department of Public Health, University of Helsinki, Finland
    Psychol Med 39:823-31. 2009
    ..Little is known about the epidemiology of bulimia nervosa outside clinical settings. We report the incidence, prevalence and outcomes of bulimia nervosa using for the first time a nationwide study design...
  42. ncbi Markers of viral infection in monozygotic twins discordant for chronic fatigue syndrome
    David M Koelle
    Department of Laboratory Medicine, University of Washington, Seattle, WA, USA
    Clin Infect Dis 35:518-25. 2002
    ..For all assays, results did not differ between the group of twins with CFS and the healthy twins...
  43. pmc Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus
    Biola M Javierre
    Chromatin and Disease Group, Cancer Epigenetics and Biology Programme PEBC, Bellvitge Biomedical Research Institute IDIBELL, L Hospitalet de Llobregat, Barcelona 08907, Spain
    Genome Res 20:170-9. 2010
    ....
  44. ncbi The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication
    Kenneth S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298, USA
    Arch Gen Psychiatry 62:529-35. 2005
    ..Prior evidence from twin studies suggested genetic moderation of the depressogenic effects of stressful life events (SLEs). Can the specific genes involved in this effect be identified?..
  45. ncbi Genetic and environmental sources of covariation between generalized anxiety disorder and neuroticism
    John M Hettema
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, P O Box 980126, Richmond, VA 23298 0126, USA
    Am J Psychiatry 161:1581-7. 2004
    ..Because women have higher levels of neuroticism and twice the risk of lifetime generalized anxiety disorder of men, gender-specific effects were also explored...
  46. ncbi Genetic and environmental factors in relative body weight and human adiposity
    H H Maes
    Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, Virginia 23298, USA
    Behav Genet 27:325-51. 1997
    ..These results are consistent with other studies in suggesting that genetic factors play a significant role in the causes of individual differences in relative body weight and human adiposity...
  47. ncbi Twins early development study (TEDS): a multivariate, longitudinal genetic investigation of language, cognition and behavior problems in childhood
    Alexandra Trouton
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London, UK
    Twin Res 5:444-8. 2002
    ..DNA has been obtained so far for more than 4000 pairs and is being used initially in molecular genetic studies of language problems and hyperactivity...
  48. pmc A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations
    Penelope A Lind
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 13:10-29. 2010
    ..Further studies will be required before the detailed causes of comorbidity between AD and ND are understood...
  49. pmc Infants with Bochdalek diaphragmatic hernia: sibling precurrence and monozygotic twin discordance in a hospital-based malformation surveillance program
    Barbara R Pober
    Genetics and Teratology, MassGeneral Hospital for Children, Boston, Massachusetts, USA
    Am J Med Genet A 138:81-8. 2005
    ..The twin data also raise the possibility that epigenetic abnormalities contribute to the development of CDH...
  50. ncbi Sex differences in genetic and environmental influences on obsessive-compulsive symptoms in South Korean adolescent and young adult twins
    Yoon Mi Hur
    Chonnam National University, Gwangju, Korea
    Twin Res Hum Genet 11:314-20. 2008
    ..41%) for the MOCIT was higher in males than in females. However, shared environmental influences did not attain statistical significance perhaps due to insufficient statistical power...
  51. ncbi A population-based twin study of the relationship between neuroticism and internalizing disorders
    John M Hettema
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, P O Box 980126, Richmond, VA 23298 0126, USA
    Am J Psychiatry 163:857-64. 2006
    ..The authors examined how genetic and environmental factors shared by the personality trait neuroticism and seven internalizing disorders may help explain this comorbidity...
  52. ncbi Do we need more twin studies? The Healthy Twin Study, Korea
    Joohon Sung
    Int J Epidemiol 35:488-90. 2006
  53. pmc The impact of environmental experiences on symptoms of anxiety and depression across the life span
    Kenneth S Kendler
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA
    Psychol Sci 22:1343-52. 2011
    ..By middle adulthood, environmental experiences contributed substantially to stable and predictable interindividual differences in levels of anxiety and depression...
  54. pmc Increased prevalence of cardiovascular defects among 56,709 California twin pairs
    J Hardin
    March of Dimes Research Division, Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Am J Med Genet A 149:877-86. 2009
    ..Increased concordance for flow lesions in monozygotic twins was observed, an observation that is in agreement with findings from familial recurrence studies of cardiovascular defects...
  55. ncbi Fetal deaths with birth defects among Japanese multiples, 1974
    Y Imaizumi
    Institute of Population Problems, Ministry of Health and Welfare, Tokyo, Japan
    Acta Genet Med Gemellol (Roma) 39:345-50. 1990
    ..The second-born twins had birth defects more frequently than the first-born twins among fetal deaths (28 vs 6)...
  56. ncbi Etiology of obsessions and compulsions: a behavioral-genetic analysis
    Steven Taylor
    Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    J Abnorm Psychol 119:672-82. 2010
    ..Gene-environment interactions were identified. Implications for an etiology-based classification system are discussed...
  57. ncbi Child psychiatric symptoms and psychosocial impairment: relationship and prognostic significance
    A Pickles
    School of Epidemiology and Health Science, University of Manchester, Manchester, UK
    Br J Psychiatry 179:230-5. 2001
    ..Relatively little is known about the relationships between psychiatric symptoms, diagnosis and psychosocial impairment...
  58. ncbi Feeling anxious: a twin study of panic/somatic ratings, anxiety sensitivity and heartbeat perception in children
    Thalia C Eley
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    J Child Psychol Psychiatry 48:1184-91. 2007
    ..We examined genetic and environmental influences on childhood AS, HBP, panic/somatic ratings, and their associations...
  59. ncbi Alternative factor models and heritability of the Short Leyton Obsessional Inventory-Children's Version
    Janette Moore
    Centre for Public Health, Department of Psychiatry, Queen s University of Belfast, Whitla Medical Building, 97Lisburn Road, Belfast, BT9 7BL, UK
    J Abnorm Child Psychol 38:921-34. 2010
    ..The correlation between the additive genetic effects for these two dimensions in males was 0.95 suggesting they largely share the same genetic risk factors...
  60. ncbi A controlled study of brain structure in monozygotic twins concordant and discordant for schizophrenia
    Neeltje E M van Haren
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 56:454-61. 2004
    ..We examined monozygotic twins concordant and discordant for schizophrenia to clarify the role of genetic and environmental factors in determining brain abnormalities...
  61. pmc Genetic and environmental influences on the rate of progression to alcohol dependence in young women
    Carolyn E Sartor
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 32:632-8. 2008
    ....
  62. pmc Genetic and environmental influences on the relationship between peer alcohol use and own alcohol use in adolescents
    Tom Fowler
    Department of Psychological Medicine, Cardiff University, Cardiff, UK
    Addiction 102:894-903. 2007
    ..Genetically influenced aspects of adolescent behaviour can play a role in alcohol use and peer affiliation. We explored the correlations between friends' alcohol use and adolescent own use with a genetically sensitive design...
  63. pmc A developmental twin study of church attendance and alcohol and nicotine consumption: a model for analyzing the changing impact of genes and environment
    Kenneth S Kendler
    Department of Psychiatry and the Virginia Institute for Psychiatricand Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298 0126, USA
    Am J Psychiatry 166:1150-5. 2009
    ....
  64. ncbi Velamentous cord insertion in monochorionic twin gestation. An added risk factor
    G A Machin
    Department of Genetics, Permanente Medical Group, Oakland, California 94611 5693, USA
    J Reprod Med 42:785-9. 1997
    ..To study the effects of umbilical cord insertion combinations on outcomes in monochorionic (MC) twin placentas...
  65. pmc Longitudinal modeling of genetic and environmental influences on self-reported availability of psychoactive substances: alcohol, cigarettes, marijuana, cocaine and stimulants
    Nathan A Gillespie
    Department of Psychiatry, Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23219 1534, USA
    Psychol Med 37:947-59. 2007
    ..Although an obvious environmental factor influencing drug use, the sources of individual differences in drug availability (DA) are unknown...
  66. pmc The epidemiology of sudden infant death syndrome
    M J Platt
    FSID Unit of Perinatal and Paediatic Epidemiology, Department of Public Health, Muspratt Laboratory, Liverpool L69 3GB, UK
    Arch Dis Child 88:27-9. 2003
    ..Twins compared to singletons are at increased risk of sudden infant death syndrome (SIDS)...
  67. ncbi Volumes of brain structures in twins discordant for schizophrenia
    W F Baaré
    Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Arch Gen Psychiatry 58:33-40. 2001
    ..The study was designed to examine the relative contributions of genetic and nongenetic factors to structural brain abnormalities in schizophrenia and subjects at risk to develop the disorder...
  68. ncbi Associations between ADH gene variants and alcohol phenotypes in Dutch adults
    Jenny H D A van Beek
    Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands
    Twin Res Hum Genet 13:30-42. 2010
    ..Although these findings do not replicate the earlier findings at the SNP level, the results confirm the role of the ADH gene cluster in alcohol phenotypes...
  69. ncbi Intrauterine growth restriction in monochorionic twins
    Zoi Russell
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of South Florida, 4 Columbia Drive, Suite 529, Tampa, FL 33606, USA
    Semin Fetal Neonatal Med 12:439-49. 2007
    ..The latter can be achieved by laser photocoagulation of communicating vessels or by umbilical-cord occlusion. The purpose of this chapter is to review this important entity in obstetrics...
  70. pmc Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes
    Shinji Kondo
    Department of Pediatrics, The University of Iowa, Iowa City, Iowa 52242, USA
    Nat Genet 32:285-9. 2002
    ..Our observations demonstrate that haploinsufficiency of IRF6 disrupts orofacial development and are consistent with dominant-negative mutations disturbing development of the skin and genitalia...
  71. ncbi Genetic modelling of childhood social development and personality in twins and siblings with schizophrenia
    M M Picchioni
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    Psychol Med 40:1305-16. 2010
    ..This study aimed to establish the degree to which these childhood and adolescent developmental abnormalities are genetically determined...
  72. ncbi Sudden infant death syndrome in twins and singletons
    Peter O D Pharoah
    Department of Public Health, University of Liverpool, Liverpool, United Kingdom
    Twin Res Hum Genet 10:644-8. 2007
    ..As congenital cerebral anomalies are a feature of many monozygous twin conceptions, a detailed macro- and microscopical examination of the brain in twin SIDS may indicate an otherwise unrecognised pathology...
  73. ncbi Joubert syndrome: monozygotic twins with discordant phenotypes
    H R Raynes
    Department of Neurology, Jacobi and Montefiore Medical Centers, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10467, USA
    J Child Neurol 14:649-54; discussion 669-72 discussio. 1999
    ..Phenotypic differences between the twins could be attributable to postzygotic unequal division of the inner cell mass, unequal sharing of the venous return from a monochorionic placenta, mosaicism, or a mutation of a modifying gene...
  74. ncbi Genetics of body mass stability and risk for chronic disease: a 28-year longitudinal study
    Carol E Franz
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093, United States of America
    Twin Res Hum Genet 10:537-45. 2007
    ..Our results also provide prospective evidence that early excess BMI may have serious long-term health consequences, and that this risk is not limited to minorities or adults of lower socioeconomic status...
  75. pmc Random T-cell receptor recruitment in human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells from genetically identical twins infected with the same HIV-1 strain
    Xu G Yu
    Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Virol 81:12666-9. 2007
    ....
  76. ncbi Effects of the family environment: gene-environment interaction and passive gene-environment correlation
    Thomas S Price
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Psychol 44:305-15. 2008
    ....
  77. ncbi Life events, anxious depression and personality: a prospective and genetic study
    C M Middeldorp
    Department of Biological Psychology, Vrije Universiteit, Van der Boechorststraat 1, Amsterdam, The Netherlands
    Psychol Med 38:1557-65. 2008
    ..The effect of genes that influence environmental exposure might be mediated through personality and we therefore also examined the association between life events and personality (neuroticism and extraversion)...
  78. ncbi Discordant pursuit asymmetry and esotropia in monozygous twins
    Pradeep Sharma
    Department of Ophthalmology, University of California, Los Angeles, USA
    Am J Ophthalmol 134:143-6. 2002
    ..To report the relationship between infantile esotropia and asymmetry of monocular pursuit tracking...
  79. ncbi Long-read sequence analysis of the MECP2 gene in Rett syndrome patients: correlation of disease severity with mutation type and location
    J P Cheadle
    Institute of Medical Genetics, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    Hum Mol Genet 9:1119-29. 2000
    ..0023), and milder disease was associated with late as compared with early truncating mutations ( P = 0.0190)...
  80. ncbi Concordance of strabismic phenotypes in monozygotic versus multizygotic twins and other multiple births
    Toshihiko Matsuo
    Department of Ophthalmology, Okayama University Medical School, Okayama City, Japan
    Jpn J Ophthalmol 46:59-64. 2002
    ..The concordance of strabismic phenotypes was examined in monozygotic versus multizygotic twins and other multiple births to study the role of genetic background in different types of commitant strabismus...
  81. pmc Maternal ratings of attention problems in ADHD: evidence for the existence of a continuum
    Gitta H Lubke
    Department of Psychology, University of Notre Dame, Notre Dame, IN 46556, USA
    J Am Acad Child Adolesc Psychiatry 48:1085-93. 2009
    ....
  82. ncbi Gender differences in the heritability of seasonal mood change
    K L Jang
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Psychiatry Res 70:145-54. 1997
    ..5%) and females (median, 30.5%). For both sexes, weight changes were not heritable. Sex-by-genotype analyses suggested that the genetic factors influencing female seasonality may not be the same as those influencing male seasonality...
  83. ncbi The danish twin registry: past and present
    Bent Harvald
    The Danish Twin Registry, Epidemiology, Department of Public Health, University of Southern Denmark, Odense, Denmark
    Twin Res 7:318-35. 2004
    ..The Danish Twin Registry was established formally in 1954 and thus celebrates its 50th anniversary in 2004. Here we give an account of its founding and the early years, and a brief summary of more recent progress...
  84. ncbi Discordant Duane's retraction syndrome in monozygotic twins
    D E Smith
    Kansas University Medical Center, USA
    Am J Ophthalmol 122:749-50. 1996
    ..To evaluate whether differences in the intrauterine environment caused discordant Duane's retraction syndrome in monozygotic twins...
  85. ncbi Prevalence, concordance, and heritability of Scheuermann kyphosis based on a study of twins
    Frank Damborg
    Department of Orthopaedic Surgery, The Spine Section, University Hospital of Odense, Soender Boulevard 29, DK 5000 Odense, Denmark
    J Bone Joint Surg Am 88:2133-6. 2006
    ..These estimates indicate to what extent genetic factors contribute to the etiology of this disease...
  86. ncbi Fetal growth and the fetal origins hypothesis in twins--problems and perspectives
    D I Phillips
    MRC Unit University of Southampton, Southampton General Hospital, UK
    Twin Res 4:327-31. 2001
    ..While, these findings may reflect methodological limitations, it is also argued that they arise as a consequence of the substantially different biology of fetal growth in twins...
  87. pmc Risk of oral clefts in twins
    Dorthe Grosen
    Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Epidemiology 22:313-9. 2011
    ..Small studies have indicated that twinning increases the risk of oral cleft...
  88. ncbi 1995 Volvo Award in clinical sciences. Determinants of lumbar disc degeneration. A study relating lifetime exposures and magnetic resonance imaging findings in identical twins
    M C Battié
    Department of Physical Therapy, University of Alberta, Edmonton, Canada
    Spine (Phila Pa 1976) 20:2601-12. 1995
    ..Retrospective cohort...
  89. pmc Prefrontal and striatal volumes in monozygotic twins concordant and discordant for schizophrenia
    Ulrich Ettinger
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstr 7, 80336, Munich, Germany
    Schizophr Bull 38:192-203. 2012
    ..There were no significant group differences in IFC and the striatum. We conclude that the prefrontal cortex shows a heterogeneous pattern of genetic influences on volumetric reductions in schizophrenia...
  90. ncbi The Twin Spine Study: contributions to a changing view of disc degeneration
    Michele C Battie
    Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada
    Spine J 9:47-59. 2009
    ..The Twin Spine Study, a research program on the etiology and pathogenesis of disc degeneration, has contributed to a substantial revision of this view of determinants of lumbar disc degeneration...
  91. ncbi Toward a comprehensive developmental model for major depression in men
    Kenneth S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics and the Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Am J Psychiatry 163:115-24. 2006
    ..In 2002, the authors presented a developmental model for major depression in women. Based on similar methods, they here present an analogous model for men...
  92. ncbi Personality and major depression: a Swedish longitudinal, population-based twin study
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia Virginia Commonwealth University, Richmond, VA 23298, USA
    Arch Gen Psychiatry 63:1113-20. 2006
    ..Prior studies suggest that the personality traits of neuroticism and extroversion may be related to the liability to major depression (MD)...
  93. ncbi Twinning
    Judith G Hall
    Department of Paediatrics, 4480 Oak Street, Room 2D19, British Columbia s Children s Hospital, BC, V6H 3V4, Vancouver, Canada
    Lancet 362:735-43. 2003
    ....
  94. ncbi Impact of genetics in childhood asthma
    Leonardo A Pinto
    Instituto de Pesquisas Biomédicas, Hospital Sao Lucas, Pontificia Universidade Catolica do Rio Grande do Sul PUCRS, Porto Alegre, RS, Brazil
    J Pediatr (Rio J) 84:S68-75. 2008
    ..To present the most important and recent results of studies on asthma genetics. These data may help general physicians understand the impact of genetics on this complex disorder and how genes and polymorphisms influence asthma and atopy...
  95. pmc Twin concordance and sibling recurrence rates in multiple sclerosis
    C J Willer
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Proc Natl Acad Sci U S A 100:12877-82. 2003
    ..8%) for female DZ pairs. We did not demonstrate an MZ/DZ difference in males, although the sample size was small. We observed a 2-fold increase in risk to DZ twins over nontwin siblings of twins, but the difference was not significant...
  96. ncbi Role of genes and environments for explaining Alzheimer disease
    Margaret Gatz
    Department of Psychology, University of Southern California, Los Angeles 90089 1061, USA
    Arch Gen Psychiatry 63:168-74. 2006
    ..Twin studies using selected samples have shown high heritability for Alzheimer disease (AD)...
  97. ncbi Complete ascertainment of dementia in the Swedish Twin Registry: the HARMONY study
    Margaret Gatz
    Department of Psychology, University of Southern California, 3620 McClintock Avenue, Los Angeles, CA 90089 1061, USA
    Neurobiol Aging 26:439-47. 2005
    ..Among monozygotic twins where both twins had Alzheimer's disease, the within pair difference in age of onset ranged from both becoming demented in the same year to 7 years difference in onset...
  98. ncbi Heterogeneity of type I diabetes: analysis of monozygotic twins in Great Britain and the United States
    M J Redondo
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Box B140, 4200 East 9th Avenue, Denver, CO 80262, USA
    Diabetologia 44:354-62. 2001
    ..An age-related heterogeneity was observed, with higher progression to diabetes for twins of patients diagnosed at a younger age...
  99. ncbi The influence of genetic factors and life stress on depression among adolescent girls
    J Silberg
    Virginia Institute for Psychiatric and Behavioral Genetics, Commonwealth University, Richmond 23298 0003, USA
    Arch Gen Psychiatry 56:225-32. 1999
    ....
  100. pmc Rethinking shared environment as a source of variance underlying attention-deficit/hyperactivity disorder symptoms: comment on Burt (2009)
    Alexis C Wood
    Department of Epidemiology and Section on Statistical Genetics, University of Alabama at Birmingham, AL 35294, USA
    Psychol Bull 136:331-40. 2010
    ..We offer suggestions for future research to address these issues, and we emphasize the need for additional research to examine possible shared environmental factors related to ADHD...
  101. pmc A common genetic factor underlies hypertension and other cardiovascular disorders
    Frances M K Williams
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London SE1 7EH, UK
    BMC Cardiovasc Disord 4:20. 2004
    ..This study used a classical twin design to examine whether these conditions are linked through shared environmental exposures or by a common underlying genetic propensity to vasospasm...

Research Grants68

  1. The Epidemiology of Mood, Anxiety and Alcohol Disorder
    Kenneth Kendler; Fiscal Year: 2004
    ....
  2. Axis I & Axis II Psychiatric Disorders in Norwegian Twin
    Kenneth Kendler; Fiscal Year: 2007
    ..This study has the capacity to address several key and largely unanswered empirical questions about PDs, the answers to which will be critical for proposed revisions in DSM-V. ..
  3. A Twin-Family Study of Drug Use, Abuse, and Dependence
    Kenneth Kendler; Fiscal Year: 2007
    ..abstract_text> ..
  4. THE GENETIC EPIDEMIOLOGY OF SCHIZOPHRENIA IN IRELAND
    Kenneth Kendler; Fiscal Year: 2008
    ..In this competitive renewal, we request 5 further years of support with the primary goals of identifying these pathogenic variant(s) and relating them to the biology of the gene, gene product and disease. ..
  5. An Irish Affected Sib Pair Study of Alcohol Dependence
    Kenneth Kendler; Fiscal Year: 2005
    ..To conduct this project we have assembled a team of experts in clinical assessment, statistical genetics and molecular genetics...
  6. Heritability of Transitions in Women's Alcohol Use/Dependence
    Carolyn Sartor; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  7. Dementia in Swedish Twins Data Archiving
    Margaret Gatz; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  8. Genetic Epidemiology of Pathological Gambling
    Wendy Slutske; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  9. DEMENTIA IN SWEDISH TWINS
    Margaret Gatz; Fiscal Year: 2002
    ..Different diagnostic criteria will be compared. Quantitative indices will be derived from neuropsychological scores and from neuroimaging data subjected to quantitative mapping. ..
  10. A Twin Study of Cognitive Outcomes in Older Adult Cancer
    Margaret Gatz; Fiscal Year: 2006
    ..Through abstracting data from cancer treatment records and linking them to existing datasets, we will be able to examine possible longer term effects, along with likely covariates, with optimal comparison groups. ..
  11. SES, health behaviors and CVD among Vietnam-era-Twins
    Jeanne McCaffery; Fiscal Year: 2005
    ..The primary method of analysis will be twin structural equation modeling. ..
  12. Genetic Predictors of Comorbid Depressive Symptoms + CAD
    Jeanne McCaffery; Fiscal Year: 2005
    ....
  13. ASSORTMENT AND TRANSMISSION OF ALCOHOL AND TOBACCO USE
    Chandra Reynolds; Fiscal Year: 2001
    ..abstract_text> ..
  14. Genetic Influence on Personality Disorder
    Jeanette Taylor; Fiscal Year: 2004
    ..abstract_text> ..
  15. Familial Transmission of Eating Pathology & Sex Hormones
    Kelly Klump; Fiscal Year: 2002
    ..abstract_text> ..
  16. Cholesterol metabolism pathway: Cognitive change and Alzheimer's disease risk
    Chandra A Reynolds; Fiscal Year: 2010
    ....
  17. Latent Growth Curve Paths to Longevity: The Terman Study
    Chandra Reynolds; Fiscal Year: 2008
    ..abstract_text> ..
  18. Genetic and Environmental Risk for Eating Disorders
    Kelly Klump; Fiscal Year: 2003
    ..Findings from this study will significantly increase understanding of developmental risk factors for eating disorders and potentially inform intervention and prevention efforts aimed at their amelioration. ..
  19. Working Memory and Social Functioning in Schizophrenia
    Tyrone Cannon; Fiscal Year: 2007
    ..abstract_text> ..
  20. Mechanisms Linking Depression to Cardiovascular Risk
    Viola Vaccarino; Fiscal Year: 2010
    ..abstract_text> ..
  21. The VETSA Longitudinal Twin Study of Cortisol and Aging
    William Kremen; Fiscal Year: 2007
    ..Using multivariate twin analytic approaches, we will determine the extent of genetic, and shared and unique environmental factors influencing cortisol in midlife as well as their association with other key measures. ..
  22. Posttraumatic Stress Disorder and Cardiovascular Disease
    Viola Vaccarino; Fiscal Year: 2007
    ..Efforts toward the prevention, early identification and treatment of PTSD and the identification of factors that mediate its adverse effects could reduce morbidity and mortality from CVD. ..
  23. Neural Phenotypes for Schizophrenia and Bipolar Disorder
    Tyrone D Cannon; Fiscal Year: 2010
    ....
  24. Environmental Risks for Smoking: A Genetically Informed Children of Twins Design
    Hong Xian; Fiscal Year: 2009
    ..The strengths of the application are the availability of smoking, psychiatric data &environmental constructs that have been previously collected from twins, offspring &mothers. ..
  25. 2/2 A genome-wide association study to detect genetic variation for schizophrenia
    Patrick F Sullivan; Fiscal Year: 2010
    ..Case-finding efforts could be greatly improved and we could learn far more about how this devastating disease develops. ..
  26. Genetic Epidemiology of Eating Disordered Behavior
    Suzanne Mazzeo; Fiscal Year: 2008
    ..It will also provide Dr. Mazzeo with the requisite training to become an independent investigator in the genetic epidemiology of eating disorders. ..
  27. Preventing Psychiatric Sequelae of Traumatic Injury
    Murray Stein; Fiscal Year: 2003
    ..Findings will provide justification for and information about optimal parameters (e.g., subject selection; sample size; dose and duration) for a future randomized controlled trial (RCT). ..
  28. Pharmacological fMRI to Identify New Anxiolytics: A Human Bioassay
    Murray Stein; Fiscal Year: 2008
    ..Enhancing the development of new treatments for anxiety is a public health priority. The projects proposed in this application have the potential to achieve this important aim. [unreadable] [unreadable] [unreadable]..
  29. Development Epidemiology of PTSD
    Karestan Koenen; Fiscal Year: 2008
    ..This work will help the development of prevention and treatment interventions for traumatized individuals and will contribute to our understanding of the etiology of PTSD. ..
  30. Major Depression: Stage 1 Genomewide Association in Population-Based Samples
    Patrick Sullivan; Fiscal Year: 2007
    ..This is arguably the best and most comprehensive sample collection for MDD in the world. [unreadable] [unreadable] [unreadable]..
  31. Identification of Susceptibility Genes for the Anxiety Disorders
    JOHN HETTEMA; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  32. DSM-IV ADHD IN AN ETHNICALLY DIVERSE COMMUNITY SAMPLE
    Erik Willcutt; Fiscal Year: 2004
    ..abstract_text> ..
  33. Genetic Determinants of PTSD in Women
    Karestan C Koenen; Fiscal Year: 2010
    ....
  34. AUSTRALASIAN COLORECTAL CANCER FAMILY REGISTRY
    John Hopper; Fiscal Year: 2007
    ..i ..
  35. The Efficacy of Reiki in the Treatment of Fibromyalgia & CFS
    Dedra Buchwald; Fiscal Year: 2003
    ..This pilot study could potentially impact the clinical care of the estimated 6 million Americans with FM, and shape the design of future larger, randomized, placebo-controlled trials of Reiki and other energy therapies. ..
  36. High-risk health behaviors, health services use & aging
    James Romeis; Fiscal Year: 2003
    ..The research project will add significantly to the literature on the role of genetics in understanding persistence of high- risk behaviors in the context of aging. ..
  37. Determinants of Behavioral Development
    Sally J Wadsworth; Fiscal Year: 2010
    ..Thus, the continuation of HD010333 will provide the foundation for a truly unique adoption study of behavioral development, spanning Infancy through early adulthood. ..
  38. GENETIC AND MOLECULAR BASIS OF FAMILIAL COLD URTICARIA
    Harold Hoffman; Fiscal Year: 2002
    ..The achievement of these goals will result in identification of the gene responsible for familial cold urticaria which will ultimately lead to an understanding of the mechanism of the inflammatory response to a physical stimulus. ..
  39. MEDIATION AND MODERATION OF GENETIC RISK FOR ALCOHOLISM
    Carol Prescott; Fiscal Year: 2002
    ..To facilitate this, the candidate will obtain training in behavioral pharmacology and molecular genetics. ..
  40. IMPROVING CARE FOR PANIC DISORDER IN PRIMARY CARE
    Murray Stein; Fiscal Year: 2002
    ..abstract_text> ..
  41. Twin Study of ADHD, CD and Substance Abuse
    William G Iacono; Fiscal Year: 2010
    ..abstract_text> ..
  42. Improving Outcomes in Pharmacotherapy of Social Phobia
    Murray Stein; Fiscal Year: 2009
    ..It thus directly addresses a critical public health issue that adversely affects a substantial proportion of the population. ..
  43. Etiology of Reading Disabilities and Comorbid ADHD
    Erik Willcutt; Fiscal Year: 2009
    ..abstract_text> ..
  44. 1/5-The Psychiatric GWAS Consortium: Integrated & Coordinated GWAS Meta-Analyses
    Patrick Sullivan; Fiscal Year: 2008
    ..Finally, the PGC proposes to abide as fully as possible with the NIH's GWAS data sharing policies and we provide a detailed data sharing plan and timetable. [unreadable] [unreadable] [unreadable]..
  45. RISK FACTORS FOR YOUNG ADULT HODGKIN'S DISEASE IN TWINS
    Wendy Cozen; Fiscal Year: 2004
    ..6 and as high as 2.0 at 80% power. A matched case-control analysis will be performed using multivariate logistic regression in SAS. ..
  46. TWIN FAMILY STUDY OF VULNERABILITY TO SUBSTANCE ABUSE
    William Iacono; Fiscal Year: 2007
    ..abstract_text> ..
  47. Validity of DSM-IV ADHD Subtypes in a Community Sample
    Erik Willcutt; Fiscal Year: 2005
    ....
  48. Cytokine Polymorphisms and Hodgkin Lymphoma Risk
    Wendy Cozen; Fiscal Year: 2006
    ..This study is important since it may will lead to identification of causal genetic factors which may offer alternative therapeutic strategies or prevention. ..
  49. GENETIC & ENVIRONMENT DETERMINANTS OF SMOKING CESSATION
    Patrick Sullivan; Fiscal Year: 2006
    ....
  50. Genetics of Fear and Anxiety Disorders
    JOHN HETTEMA; Fiscal Year: 2006
    ..abstract_text> ..
  51. Gene-enviornment interactions in facial clefts
    Kaare Christensen; Fiscal Year: 2006
    ..This study will provide a new level of understanding for a complex birth defect trait. ..
  52. Risk Factors for Non Hodgkin's Lymphoma in Twins
    Wendy Cozen; Fiscal Year: 2006
    ..6 and as high as 1.8. A matched case-control analysis using SAS will be performed using multivariate logistic regression. [unreadable] [unreadable]..
  53. Causes of Comorbidity:Substance Use Disorder, ADHD & CD
    Soo Rhee; Fiscal Year: 2005
    ....
  54. Microarrays & Proteomics in MZ Twins Discordant for CFS
    Patrick Sullivan; Fiscal Year: 2006
    ..If successful, this work could lead to profound changes in the understanding of CFS and resolution of some attendant controversies. ..
  55. Novel regulatory role of cryopyrin in inflammation
    Harold Hoffman; Fiscal Year: 2005
    ..abstract_text> ..
  56. Longitudinal Twin Study of Reading Disability
    Sally Wadsworth; Fiscal Year: 2006
    ..Univariate and bivariate QTL analyses of reading deficits and ADHD, reading component processes and other psychopathology will also be conducted. ..
  57. Replication of Schizophrenia Associations in CATIE
    Patrick Sullivan; Fiscal Year: 2007
    ..We believe that the results of our study will be highly informative and are essential to the field at this critical juncture in the hunt for genes mediating liability to schizophrenia. [unreadable] [unreadable]..
  58. Neuroanatomy and Cognition in Velocardiofacial Syndrome
    Wendy Kates; Fiscal Year: 2005
    ....
  59. DETECTING SUSCEPTIBILITY LOCI FOR RECURRENT DEPRESSION
    Patrick Sullivan; Fiscal Year: 2002
    ..abstract_text> ..
  60. Epidemiologic Study of Placental Abruption
    Cande Ananth; Fiscal Year: 2006
    ..It will also add substantial new evidence for associations of several genetic thrombophilias and abruption risk. ..
  61. Androgen Receptor as a Biomarker in Prostate Cancer Progression
    Ann Hamilton; Fiscal Year: 2007
    ..It will also lay the groundwork for larger studies examining. [unreadable] [unreadable] [unreadable]..
  62. Electrophysiology and Neurocognition in Schizophrenia
    Peter Bachman; Fiscal Year: 2004
    ..abstract_text> ..
  63. Vitamins, Breast Milk HIV Shedding and Child Health
    Eduardo Villamor; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  64. Biological Factors for Age-Related Macular Degeneration
    Johanna Seddon; Fiscal Year: 2004
    ..abstract_text> ..
  65. Chromosome Analysis of Single Cells
    Brynn Levy; Fiscal Year: 2007
    ..abstract_text> ..
  66. GENETICS OF ADHD
    Josephine Elia; Fiscal Year: 2007
    ..Dr. Douglas Levinson will provide mentoring in statistical methods and data analyses and Dr. Judith Rapoport will provide mentoring in defining novel phenotypic definitions for ADHD. ..
  67. Genetic Determinants of Bipolar Disorder
    Jordan Smoller; Fiscal Year: 2007
    ..An important dividend of this large study will be the expansion of the repository to include DNA data on relatives and on an independent sample of controls, thus facilitating future genetic studies. ..
  68. Longitudinal Effects of Sleep Problems on Cognition
    NAOMI FRIEDMAN; Fiscal Year: 2007
    ..These proposed analyses will result in more comprehensive and powerful models of sleep problems and cognitive function. [unreadable] [unreadable] [unreadable]..