diseases in twins

Summary

Summary: Disorders affecting TWINS, one or both, at any age.

Top Publications

  1. ncbi The UK Adult Twin Registry (TwinsUK)
    Tim D Spector
    Twin Research and Genetic Epidemiology Unit, Kings College London, St Thomas Hospital Campus, London, UK
    Twin Res Hum Genet 9:899-906. 2006
  2. ncbi Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins
    G Kuratomi
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Hirosawa, Wako, Saitama, Japan
    Mol Psychiatry 13:429-41. 2008
  3. ncbi Personality and major depression: a Swedish longitudinal, population-based twin study
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia Virginia Commonwealth University, Richmond, VA 23298, USA
    Arch Gen Psychiatry 63:1113-20. 2006
  4. doi Incidence and outcomes of bulimia nervosa: a nationwide population-based study
    A Keski-Rahkonen
    Department of Public Health, University of Helsinki, Finland
    Psychol Med 39:823-31. 2009
  5. ncbi Discordant KCNQ1OT1 imprinting in sets of monozygotic twins discordant for Beckwith-Wiedemann syndrome
    Rosanna Weksberg
    Division of Clinical and Metabolic Genetics and the Research Institute, Department of Paediatrics Hospital for Sick Children, Toronto, Ontario, Canada
    Hum Mol Genet 11:1317-25. 2002
  6. doi The Twin Spine Study: contributions to a changing view of disc degeneration
    Michele C Battie
    Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada
    Spine J 9:47-59. 2009
  7. pmc Alcohol consumption indices of genetic risk for alcohol dependence
    Julia D Grant
    Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biol Psychiatry 66:795-800. 2009
  8. ncbi Genetic aspects of normal and disturbed sleep
    Mehdi Tafti
    Center for Integrative Genomics, University of Lausanne, Genopode, 1015 Lausanne, Switzerland
    Sleep Med 10:S17-21. 2009
  9. ncbi A Swedish national twin study of lifetime major depression
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Am J Psychiatry 163:109-14. 2006
  10. pmc A developmental twin study of symptoms of anxiety and depression: evidence for genetic innovation and attenuation
    K S Kendler
    Virginia Institute of Psychiatric and Behavioral Genetics, Medical College of Virginia Virginia Commonwealth University, Richmond, VA, USA
    Psychol Med 38:1567-75. 2008

Research Grants

Detail Information

Publications239 found, 100 shown here

  1. ncbi The UK Adult Twin Registry (TwinsUK)
    Tim D Spector
    Twin Research and Genetic Epidemiology Unit, Kings College London, St Thomas Hospital Campus, London, UK
    Twin Res Hum Genet 9:899-906. 2006
    ..The resource has led to many successful and innovative research projects particularly in common age-related diseases, and has led to collaborations with over 80 groups worldwide...
  2. ncbi Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins
    G Kuratomi
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Hirosawa, Wako, Saitama, Japan
    Mol Psychiatry 13:429-41. 2008
    ..We found strong inverse correlation between gene expression and DNA methylation levels of PPIEL. These results suggest that altered DNA methylation statuses of PPIEL might have some significance in pathophysiology of bipolar disorder....
  3. ncbi Personality and major depression: a Swedish longitudinal, population-based twin study
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia Virginia Commonwealth University, Richmond, VA 23298, USA
    Arch Gen Psychiatry 63:1113-20. 2006
    ..Prior studies suggest that the personality traits of neuroticism and extroversion may be related to the liability to major depression (MD)...
  4. doi Incidence and outcomes of bulimia nervosa: a nationwide population-based study
    A Keski-Rahkonen
    Department of Public Health, University of Helsinki, Finland
    Psychol Med 39:823-31. 2009
    ..Little is known about the epidemiology of bulimia nervosa outside clinical settings. We report the incidence, prevalence and outcomes of bulimia nervosa using for the first time a nationwide study design...
  5. ncbi Discordant KCNQ1OT1 imprinting in sets of monozygotic twins discordant for Beckwith-Wiedemann syndrome
    Rosanna Weksberg
    Division of Clinical and Metabolic Genetics and the Research Institute, Department of Paediatrics Hospital for Sick Children, Toronto, Ontario, Canada
    Hum Mol Genet 11:1317-25. 2002
    ..These data underscore the importance of continued surveillance of children born following assisted reproductive technologies that impact the preimplantation embryo...
  6. doi The Twin Spine Study: contributions to a changing view of disc degeneration
    Michele C Battie
    Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada
    Spine J 9:47-59. 2009
    ..The Twin Spine Study, a research program on the etiology and pathogenesis of disc degeneration, has contributed to a substantial revision of this view of determinants of lumbar disc degeneration...
  7. pmc Alcohol consumption indices of genetic risk for alcohol dependence
    Julia D Grant
    Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biol Psychiatry 66:795-800. 2009
    ..A high genetic correlation between these measures would suggest that a continuous measure of consumption may have a useful role in the discovery of genes contributing to dependence risk...
  8. ncbi Genetic aspects of normal and disturbed sleep
    Mehdi Tafti
    Center for Integrative Genomics, University of Lausanne, Genopode, 1015 Lausanne, Switzerland
    Sleep Med 10:S17-21. 2009
    ....
  9. ncbi A Swedish national twin study of lifetime major depression
    Kenneth S Kendler
    Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Am J Psychiatry 163:109-14. 2006
    ..It is not known whether genetic effects on major depression are constant across historical cohorts...
  10. pmc A developmental twin study of symptoms of anxiety and depression: evidence for genetic innovation and attenuation
    K S Kendler
    Virginia Institute of Psychiatric and Behavioral Genetics, Medical College of Virginia Virginia Commonwealth University, Richmond, VA, USA
    Psychol Med 38:1567-75. 2008
    ..Analysis conducted using the Mx program included SxAnxDep by parental and self-report...
  11. doi Failure to confirm CNVs as of aetiological significance in twin pairs discordant for schizophrenia
    Shinji Ono
    Department of Human Genetics, Nagasaki University Graduate School of Biomedical Sciences, Japan
    Twin Res Hum Genet 13:455-60. 2010
    ..Schizophrenia caused by strong genetics factors including copy number alteration or gene mutation may be a small subset of the clinical population...
  12. pmc Influence of twin-twin transfusion syndrome on fetal cardiovascular structure and function: prospective case-control study of 136 monochorionic twin pregnancies
    A A Karatza
    Department of Maternal Fetal Medicine, Queen Charlotte s and Chelsea Hospital, Imperial College, London, UK
    Heart 88:271-7. 2002
    ..To test the hypothesis that identical twins show no inter-twin differences in cardiovascular structure or physiology in fetal life unless there has been twin-twin transfusion syndrome...
  13. pmc Adiposity is inversely related to insulin sensitivity in relatively lean Chinese adolescents: a population-based twin study
    Fengxiu Ouyang
    Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Am J Clin Nutr 91:662-71. 2010
    ..Adolescence is a critical period for rising adiposity and falling insulin sensitivity (IS), but the independent relation between adiposity and IS remains understudied...
  14. ncbi Genetic predisposition to organ-specific endpoints of alcoholism
    T Reed
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, USA
    Alcohol Clin Exp Res 20:1528-33. 1996
    ....
  15. ncbi The Swedish Twin Registry in the third millennium: an update
    Paul Lichtenstein
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Twin Res Hum Genet 9:875-82. 2006
    ..In particular, we describe recent efforts to screen all twins born between 1959 and 1985, and young twin pairs when they turn 9 and 12 years of age. For these studies, we present initial frequencies of common conditions and exposures...
  16. ncbi Life satisfaction and depression in a 15-year follow-up of healthy adults
    Heli Koivumaa-Honkanen
    Dept of Psychiatry 2700, Kuopio University Hospital, P O B 1777, 70211 Kuopio, Finland
    Soc Psychiatry Psychiatr Epidemiol 39:994-9. 2004
    ..The aim of this study was to investigate the cross-sectional and longitudinal relationship between life satisfaction and depressive symptoms in healthy adults...
  17. ncbi Gray and white matter volume abnormalities in monozygotic and same-gender dizygotic twins discordant for schizophrenia
    Hilleke E Hulshoff Pol
    Rudolf Magnus Institute for Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 55:126-30. 2004
    ....
  18. doi Phenotypic and genetic differentiation of anxiety-related behaviors in middle childhood
    Victoria Hallett
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London, UK
    Depress Anxiety 26:316-24. 2009
    ..This study aimed to examine both the phenotypic and genetic differentiation of ARB subtypes within the general population at age 7 and 9. It constituted a follow-up to an earlier study of ARBs in preschool children...
  19. ncbi A longitudinal study of personality and major depression in a population-based sample of male twins
    Ayman H Fanous
    Washington VA Medical Center, Washington, DC 20422, USA
    Psychol Med 37:1163-72. 2007
    ..The relationship between personality and psychiatric illness is complex. It is not clear whether one directly causes the other...
  20. pmc Familial aggregation of amyotrophic lateral sclerosis
    Fang Fang
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Ann Neurol 66:94-9. 2009
    ..To assess the relative risk for amyotrophic lateral sclerosis (ALS) in families of ALS patients...
  21. pmc Gene expression in peripheral blood leukocytes in monozygotic twins discordant for chronic fatigue: no evidence of a biomarker
    Andrea Byrnes
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 4:e5805. 2009
    ..Chronic fatiguing illness remains a poorly understood syndrome of unknown pathogenesis. We attempted to identify biomarkers for chronic fatiguing illness using microarrays to query the transcriptome in peripheral blood leukocytes...
  22. pmc Rethinking shared environment as a source of variance underlying attention-deficit/hyperactivity disorder symptoms: comment on Burt (2009)
    Alexis C Wood
    Department of Epidemiology and Section on Statistical Genetics, University of Alabama at Birmingham, AL 35294, USA
    Psychol Bull 136:331-40. 2010
    ..We offer suggestions for future research to address these issues, and we emphasize the need for additional research to examine possible shared environmental factors related to ADHD...
  23. ncbi Boundaries of major depression: an evaluation of DSM-IV criteria
    K S Kendler
    Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia of Virginia Commonwealth University, Richmond, USA
    Am J Psychiatry 155:172-7. 1998
    ..Little is known about the boundaries between major depression and milder subsyndromal depressive states. With respect to depressive symptoms, does DSM-IV "carve nature at its joints"?..
  24. pmc Genetic and environmental contributions to phenotypic components of metabolic syndrome: a population-based twin study
    Shanchun Zhang
    Mary Ann and J Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children s Memorial Hospital and Children s Memorial Research Center, Chicago, Illinois, USA
    Obesity (Silver Spring) 17:1581-7. 2009
    ..Our study underscores the importance of examining MS components as intercorrelated traits, and to carefully consider environmental and genetic factors in studying MS etiology...
  25. ncbi The five-factor model of personality and borderline personality disorder: a genetic analysis of comorbidity
    Marijn A Distel
    Department of Biological Psychology, VU University Amsterdam, 1081 BT Amsterdam, The Netherlands
    Biol Psychiatry 66:1131-8. 2009
    ....
  26. ncbi Genetic and phenotypic stability of measures of neuroticism over 22 years
    Naomi R Wray
    Genetic Epidermology, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 10:695-702. 2007
    ..33 for a single measure to .43 for mean score because of the reduction in the estimate of the environmental variance, and this will increase power in genetic linkage or association studies of neuroticism...
  27. ncbi Comorbidity with low back pain: a cross-sectional population-based survey of 12- to 22-year-olds
    Lise Hestbaek
    Back Research Center, Ringe, Denmark
    Spine (Phila Pa 1976) 29:1483-91; discussion 1492. 2004
    ..Cross-sectional, population-based survey...
  28. doi Amygdala responses to emotional faces in twins discordant or concordant for the risk for anxiety and depression
    Saskia P A Wolfensberger
    Department of Psychiatry, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Neuroimage 41:544-52. 2008
    ..To account for these discrepant findings, we hypothesize that genetic and environmental risk factors differently impact on amygdala functioning...
  29. ncbi The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication
    Kenneth S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298, USA
    Arch Gen Psychiatry 62:529-35. 2005
    ..Prior evidence from twin studies suggested genetic moderation of the depressogenic effects of stressful life events (SLEs). Can the specific genes involved in this effect be identified?..
  30. ncbi Genetic and environmental sources of covariation between generalized anxiety disorder and neuroticism
    John M Hettema
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, P O Box 980126, Richmond, VA 23298 0126, USA
    Am J Psychiatry 161:1581-7. 2004
    ..Because women have higher levels of neuroticism and twice the risk of lifetime generalized anxiety disorder of men, gender-specific effects were also explored...
  31. ncbi Genetic and environmental factors in relative body weight and human adiposity
    H H Maes
    Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, Virginia 23298, USA
    Behav Genet 27:325-51. 1997
    ..These results are consistent with other studies in suggesting that genetic factors play a significant role in the causes of individual differences in relative body weight and human adiposity...
  32. pmc Genetic and environmental influences on the relationship between peer alcohol use and own alcohol use in adolescents
    Tom Fowler
    Department of Psychological Medicine, Cardiff University, Cardiff, UK
    Addiction 102:894-903. 2007
    ..Genetically influenced aspects of adolescent behaviour can play a role in alcohol use and peer affiliation. We explored the correlations between friends' alcohol use and adolescent own use with a genetically sensitive design...
  33. pmc Genetic and environmental influences on the rate of progression to alcohol dependence in young women
    Carolyn E Sartor
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 32:632-8. 2008
    ....
  34. ncbi Toward a comprehensive developmental model for major depression in men
    Kenneth S Kendler
    Virginia Institute for Psychiatry and Behavioral Genetics and the Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Am J Psychiatry 163:115-24. 2006
    ..In 2002, the authors presented a developmental model for major depression in women. Based on similar methods, they here present an analogous model for men...
  35. pmc A developmental twin study of church attendance and alcohol and nicotine consumption: a model for analyzing the changing impact of genes and environment
    Kenneth S Kendler
    Department of Psychiatry and the Virginia Institute for Psychiatricand Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298 0126, USA
    Am J Psychiatry 166:1150-5. 2009
    ....
  36. pmc Longitudinal modeling of genetic and environmental influences on self-reported availability of psychoactive substances: alcohol, cigarettes, marijuana, cocaine and stimulants
    Nathan A Gillespie
    Department of Psychiatry, Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23219 1534, USA
    Psychol Med 37:947-59. 2007
    ..Although an obvious environmental factor influencing drug use, the sources of individual differences in drug availability (DA) are unknown...
  37. ncbi Velamentous cord insertion in monochorionic twin gestation. An added risk factor
    G A Machin
    Department of Genetics, Permanente Medical Group, Oakland, California 94611 5693, USA
    J Reprod Med 42:785-9. 1997
    ..To study the effects of umbilical cord insertion combinations on outcomes in monochorionic (MC) twin placentas...
  38. ncbi The genetics of anorexia nervosa
    Cynthia M Bulik
    Department of Psychiatry, University of North Carolina at Chapel Hill, NC 27599, USA
    Annu Rev Nutr 27:263-75. 2007
    ..With these bodies of literature as a starting point, we evaluate critically the current state of research on molecular genetic studies of anorexia nervosa and provide guidance for future research...
  39. pmc The epidemiology of sudden infant death syndrome
    M J Platt
    FSID Unit of Perinatal and Paediatic Epidemiology, Department of Public Health, Muspratt Laboratory, Liverpool L69 3GB, UK
    Arch Dis Child 88:27-9. 2003
    ..Twins compared to singletons are at increased risk of sudden infant death syndrome (SIDS)...
  40. pmc Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes
    Shinji Kondo
    Department of Pediatrics, The University of Iowa, Iowa City, Iowa 52242, USA
    Nat Genet 32:285-9. 2002
    ..Our observations demonstrate that haploinsufficiency of IRF6 disrupts orofacial development and are consistent with dominant-negative mutations disturbing development of the skin and genitalia...
  41. doi Associations between ADH gene variants and alcohol phenotypes in Dutch adults
    Jenny H D A van Beek
    Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands
    Twin Res Hum Genet 13:30-42. 2010
    ..Although these findings do not replicate the earlier findings at the SNP level, the results confirm the role of the ADH gene cluster in alcohol phenotypes...
  42. ncbi Intrauterine growth restriction in monochorionic twins
    Zoi Russell
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of South Florida, 4 Columbia Drive, Suite 529, Tampa, FL 33606, USA
    Semin Fetal Neonatal Med 12:439-49. 2007
    ..The latter can be achieved by laser photocoagulation of communicating vessels or by umbilical-cord occlusion. The purpose of this chapter is to review this important entity in obstetrics...
  43. ncbi Volumes of brain structures in twins discordant for schizophrenia
    W F Baaré
    Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Arch Gen Psychiatry 58:33-40. 2001
    ..The study was designed to examine the relative contributions of genetic and nongenetic factors to structural brain abnormalities in schizophrenia and subjects at risk to develop the disorder...
  44. doi A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorder
    Avshalom Caspi
    Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, England
    Arch Gen Psychiatry 65:203-10. 2008
    ..Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous neurodevelopmental disorder that in some cases is accompanied by antisocial behavior...
  45. ncbi Joubert syndrome: monozygotic twins with discordant phenotypes
    H R Raynes
    Department of Neurology, Jacobi and Montefiore Medical Centers, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10467, USA
    J Child Neurol 14:649-54; discussion 669-72 discussio. 1999
    ..Phenotypic differences between the twins could be attributable to postzygotic unequal division of the inner cell mass, unequal sharing of the venous return from a monochorionic placenta, mosaicism, or a mutation of a modifying gene...
  46. doi Genetic modelling of childhood social development and personality in twins and siblings with schizophrenia
    M M Picchioni
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    Psychol Med 40:1305-16. 2010
    ..This study aimed to establish the degree to which these childhood and adolescent developmental abnormalities are genetically determined...
  47. ncbi Sudden infant death syndrome in twins and singletons
    Peter O D Pharoah
    Department of Public Health, University of Liverpool, Liverpool, United Kingdom
    Twin Res Hum Genet 10:644-8. 2007
    ..As congenital cerebral anomalies are a feature of many monozygous twin conceptions, a detailed macro- and microscopical examination of the brain in twin SIDS may indicate an otherwise unrecognised pathology...
  48. ncbi The danish twin registry: past and present
    Bent Harvald
    The Danish Twin Registry, Epidemiology, Department of Public Health, University of Southern Denmark, Odense, Denmark
    Twin Res 7:318-35. 2004
    ..The Danish Twin Registry was established formally in 1954 and thus celebrates its 50th anniversary in 2004. Here we give an account of its founding and the early years, and a brief summary of more recent progress...
  49. ncbi Discordant pursuit asymmetry and esotropia in monozygous twins
    Pradeep Sharma
    Department of Ophthalmology, University of California, Los Angeles, USA
    Am J Ophthalmol 134:143-6. 2002
    ..To report the relationship between infantile esotropia and asymmetry of monocular pursuit tracking...
  50. doi Effects of the family environment: gene-environment interaction and passive gene-environment correlation
    Thomas S Price
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Psychol 44:305-15. 2008
    ....
  51. ncbi Fetal growth and the fetal origins hypothesis in twins--problems and perspectives
    D I Phillips
    MRC Unit University of Southampton, Southampton General Hospital, UK
    Twin Res 4:327-31. 2001
    ..While, these findings may reflect methodological limitations, it is also argued that they arise as a consequence of the substantially different biology of fetal growth in twins...
  52. doi Life events, anxious depression and personality: a prospective and genetic study
    C M Middeldorp
    Department of Biological Psychology, Vrije Universiteit, Van der Boechorststraat 1, Amsterdam, The Netherlands
    Psychol Med 38:1557-65. 2008
    ..The effect of genes that influence environmental exposure might be mediated through personality and we therefore also examined the association between life events and personality (neuroticism and extraversion)...
  53. ncbi Prevalence, concordance, and heritability of Scheuermann kyphosis based on a study of twins
    Frank Damborg
    Department of Orthopaedic Surgery, The Spine Section, University Hospital of Odense, Soender Boulevard 29, DK 5000 Odense, Denmark
    J Bone Joint Surg Am 88:2133-6. 2006
    ..These estimates indicate to what extent genetic factors contribute to the etiology of this disease...
  54. ncbi Genetics of body mass stability and risk for chronic disease: a 28-year longitudinal study
    Carol E Franz
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093, United States of America
    Twin Res Hum Genet 10:537-45. 2007
    ..Our results also provide prospective evidence that early excess BMI may have serious long-term health consequences, and that this risk is not limited to minorities or adults of lower socioeconomic status...
  55. pmc Maternal ratings of attention problems in ADHD: evidence for the existence of a continuum
    Gitta H Lubke
    Department of Psychology, University of Notre Dame, Notre Dame, IN 46556, USA
    J Am Acad Child Adolesc Psychiatry 48:1085-93. 2009
    ....
  56. ncbi Discordant Duane's retraction syndrome in monozygotic twins
    D E Smith
    Kansas University Medical Center, USA
    Am J Ophthalmol 122:749-50. 1996
    ..To evaluate whether differences in the intrauterine environment caused discordant Duane's retraction syndrome in monozygotic twins...
  57. ncbi Gender differences in the heritability of seasonal mood change
    K L Jang
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Psychiatry Res 70:145-54. 1997
    ..5%) and females (median, 30.5%). For both sexes, weight changes were not heritable. Sex-by-genotype analyses suggested that the genetic factors influencing female seasonality may not be the same as those influencing male seasonality...
  58. ncbi Long-read sequence analysis of the MECP2 gene in Rett syndrome patients: correlation of disease severity with mutation type and location
    J P Cheadle
    Institute of Medical Genetics, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    Hum Mol Genet 9:1119-29. 2000
    ..0023), and milder disease was associated with late as compared with early truncating mutations ( P = 0.0190)...
  59. ncbi Markers of viral infection in monozygotic twins discordant for chronic fatigue syndrome
    David M Koelle
    Department of Laboratory Medicine, University of Washington, Seattle, WA, USA
    Clin Infect Dis 35:518-25. 2002
    ..For all assays, results did not differ between the group of twins with CFS and the healthy twins...
  60. pmc Random T-cell receptor recruitment in human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells from genetically identical twins infected with the same HIV-1 strain
    Xu G Yu
    Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Virol 81:12666-9. 2007
    ....
  61. ncbi Concordance of strabismic phenotypes in monozygotic versus multizygotic twins and other multiple births
    Toshihiko Matsuo
    Department of Ophthalmology, Okayama University Medical School, Okayama City, Japan
    Jpn J Ophthalmol 46:59-64. 2002
    ..The concordance of strabismic phenotypes was examined in monozygotic versus multizygotic twins and other multiple births to study the role of genetic background in different types of commitant strabismus...
  62. ncbi Twinning
    Judith G Hall
    Department of Paediatrics, 4480 Oak Street, Room 2D19, British Columbia s Children s Hospital, BC, V6H 3V4, Vancouver, Canada
    Lancet 362:735-43. 2003
    ....
  63. doi Impact of genetics in childhood asthma
    Leonardo A Pinto
    Instituto de Pesquisas Biomédicas, Hospital Sao Lucas, Pontificia Universidade Catolica do Rio Grande do Sul PUCRS, Porto Alegre, RS, Brazil
    J Pediatr (Rio J) 84:S68-75. 2008
    ..To present the most important and recent results of studies on asthma genetics. These data may help general physicians understand the impact of genetics on this complex disorder and how genes and polymorphisms influence asthma and atopy...
  64. ncbi Complete ascertainment of dementia in the Swedish Twin Registry: the HARMONY study
    Margaret Gatz
    Department of Psychology, University of Southern California, 3620 McClintock Avenue, Los Angeles, CA 90089 1061, USA
    Neurobiol Aging 26:439-47. 2005
    ..Among monozygotic twins where both twins had Alzheimer's disease, the within pair difference in age of onset ranged from both becoming demented in the same year to 7 years difference in onset...
  65. ncbi Common genetic vulnerability for nicotine and alcohol dependence in men
    W R True
    School of Public Health, St Louis University Health Sciences Center, MO, USA
    Arch Gen Psychiatry 56:655-61. 1999
    ..We examined data from male twin pairs to determine whether there are genetic or environmental influences common to nicotine and alcohol dependence, and, if so, to estimate the magnitude and correlation of these influences...
  66. ncbi Role of genes and environments for explaining Alzheimer disease
    Margaret Gatz
    Department of Psychology, University of Southern California, Los Angeles 90089 1061, USA
    Arch Gen Psychiatry 63:168-74. 2006
    ..Twin studies using selected samples have shown high heritability for Alzheimer disease (AD)...
  67. pmc Twin concordance and sibling recurrence rates in multiple sclerosis
    C J Willer
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Proc Natl Acad Sci U S A 100:12877-82. 2003
    ..8%) for female DZ pairs. We did not demonstrate an MZ/DZ difference in males, although the sample size was small. We observed a 2-fold increase in risk to DZ twins over nontwin siblings of twins, but the difference was not significant...
  68. ncbi The Swedish Twin Registry: a unique resource for clinical, epidemiological and genetic studies
    P Lichtenstein
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 252:184-205. 2002
    ..In the following, we will summarize the content of the database, describe for the first time recent data collection efforts and review some of the principal findings that have come from the Registry...
  69. ncbi The influence of genetic factors and life stress on depression among adolescent girls
    J Silberg
    Virginia Institute for Psychiatric and Behavioral Genetics, Commonwealth University, Richmond 23298 0003, USA
    Arch Gen Psychiatry 56:225-32. 1999
    ....
  70. ncbi Attention-deficit/hyperactivity disorder: a selective overview
    Joseph Biederman
    Department of Pediatric Psychopharmacology Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Psychiatry 57:1215-20. 2005
    ..Such alterations in dopaminergic and noradrenergic function are apparently necessary for the clinical efficacy of pharmacologic treatments of ADHD...
  71. ncbi Heterogeneity of type I diabetes: analysis of monozygotic twins in Great Britain and the United States
    M J Redondo
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Box B140, 4200 East 9th Avenue, Denver, CO 80262, USA
    Diabetologia 44:354-62. 2001
    ..An age-related heterogeneity was observed, with higher progression to diabetes for twins of patients diagnosed at a younger age...
  72. doi Health-related and sociodemographic risk factors for disability pension due to low back disorders: a 30-year prospective Finnish Twin Cohort Study
    Sanna Pietikäinen
    Ergonomics, Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland
    J Occup Environ Med 53:488-96. 2011
    ..To investigate health-related and sociodemographic risk factors for disability pensions (DP) due to low back disorders (LBD)...
  73. pmc The genetic influence on radiographic osteoarthritis is site specific at the hand, hip and knee
    A J MacGregor
    School of Medicine, University of East Anglia, Norwich NR4 7TJ, UK
    Rheumatology (Oxford) 48:277-80. 2009
    ..To identify whether a shared genetic influence accounts for the occurrence of OA at different skeletal sites...
  74. ncbi Insulin resistance in healthy prepubertal twins
    Craig A Jefferies
    Liggins Institute, Health Research Council Biostatistics Unit, Department of Community Health, University of Auckland, Auckland, New Zealand
    J Pediatr 144:608-13. 2004
    ..To evaluate insulin sensitivity (S(I)) in prepubertal twins and to examine the relation to reduced birth weight, prematurity, and peroxisome proliferator-activated receptor-gamma (PPAR gamma) polymorphism...
  75. pmc Nonshared environmental influences on teacher-reported behaviour problems: monozygotic twin differences in perceptions of the classroom
    Bonamy R Oliver
    Social, Genetic and Developmental Psychiatry Centre, King s College London, UK
    J Child Psychol Psychiatry 49:646-53. 2008
    ..The identification of specific nonshared environments responsible for the variance in behaviour problems is a key challenge...
  76. pmc Hyperactive-impulsive symptom scores and oppositional behaviours reflect alternate manifestations of a single liability
    Alexis C Wood
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Kings College London, De Crespigny Park, London, SE5 8AF, UK
    Behav Genet 39:447-60. 2009
    ..In middle childhood, symptoms of hyperactivity-impulsivity and oppositional behaviour may represent the same underlying liability, whereas the inattentive domain is more distinct...
  77. ncbi Refractive errors in twin studies
    Mohamed Dirani
    Centre for Eye Research Australia, University of Melbourne, Australia Vision Cooperative Research Centre, Sydney, Australia
    Twin Res Hum Genet 9:566-72. 2006
    ..5 to .9. This article will review those twin studies that have investigated refractive error, particularly myopia, as well as biometric measures linked to refractive error, to compare heritability estimates and methodology designs...
  78. pmc Childhood cancer among twins and higher order multiples
    Susan E Puumala
    Division of Epidemiology Clinical Research, Department of Pediatrics, University of Minnesota, 420 Delaware Street, SE, MMC 715, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 18:162-8. 2009
    ..Our analysis suggests that mechanisms other than birth weight and gestational age may influence the lower risk of Wilms' tumor and neuroblastoma in multiple births...
  79. ncbi High constant incidence in twins and other relatives of women with breast cancer
    J Peto
    Section of Epidemiology, Institute of Cancer Research, Sutton, Surrey, UK
    Nat Genet 26:411-4. 2000
    ..The very high incidence in monozygotic twins of patients indicates that a high proportion, and perhaps the majority, of breast cancers arise in a susceptible minority of women...
  80. ncbi Gender differences in the symptoms of major depression in opposite-sex dizygotic twin pairs
    Amir A Khan
    Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
    Am J Psychiatry 159:1427-9. 2002
    ..Gender differences in the symptoms of major depression have received limited research attention. The aim of this study was to explore these differences in male-female twin pairs...
  81. ncbi Update from Sri Lankan Twin Registry: establishment of a population-based twin register and ongoing project on common mental disorders, alcohol abuse and suicidal ideations
    Sisira Hemananda Siribaddana
    Sri Lanka Twin Registry, Institute of Research and Development, Battaramulla, Sri Lanka
    Twin Res Hum Genet 9:868-74. 2006
    ..After incorporating twins and multiples from various other feasibility studies we now have 19,040 multiples with 8.46 twins per 1000 people in the Colombo district...
  82. pmc Heritable variation in food preferences and their contribution to obesity
    D R Reed
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Behav Genet 27:373-87. 1997
    ..Identifying genes involved in the excess consumption of dietary fat will be an important key to our understanding of the genetic disposition toward common dietary obesity...
  83. ncbi A multiple pregnancy register in the north of England
    Svetlana V Glinianaia
    Department of Epidemiology and Public Health, The Medical School, University of Newcastle, Newcastle upon Tyne, UK
    Twin Res 5:436-9. 2002
    ..6 per 1000 livebirths respectively. A prospective Multiple Pregnancy Register not only allows monitoring of trends in multiple birth rates and mortality, but also etiological research and long-term follow-up studies...
  84. pmc Genetic regulation of human anti-malarial antibodies in twins
    K Sjoberg
    Department of Immunology, Stockholm University, Sweden
    Proc Natl Acad Sci U S A 89:2101-4. 1992
    ..This suggests that the regulation of the Pf155/RESA antibody responses seen in this study reflects the impact of factors encoded by genes outside the HLA class II regions...
  85. ncbi Disordered eating and substance use in an epidemiological sample: II. Associations within families
    Kristin M von Ranson
    Dept of Psychology, University of Minnesota Twin Cities Campus, Minneapolis, MN, USA
    Psychol Addict Behav 17:193-201. 2003
    ..These results suggest that these problems are not cross-transmitted within families and suggest that the addiction model of eating disorders may be simplistic...
  86. ncbi Association between broadly defined bulimia nervosa and drug use disorders: common genetic and environmental influences
    Jessica H Baker
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA
    Int J Eat Disord 40:673-8. 2007
    ..Previous research has shown an association between bulimia (BN) and drug use disorders (DUD). The purpose of the present study was to investigate possible influences on the comorbidity between BN and DUD...
  87. ncbi Heritability for Alzheimer's disease: the study of dementia in Swedish twins
    M Gatz
    Department of Psychology, University of Southern California, Los Angeles, USA
    J Gerontol A Biol Sci Med Sci 52:M117-25. 1997
    ..In this study, our purpose was to detect all cases of dementia in an established twin registry and to estimate total extent of genetic contribution to liability to Alzheimer's disease...
  88. pmc Structure of genetic and environmental risk factors for dimensional representations of DSM-IV anxiety disorders
    Kristian Tambs
    Department of Mental Health, Norwegian Institute of Public Health, Box 4404 Nydalen, 0403 Oslo 3, Norway
    Br J Psychiatry 195:301-7. 2009
    ..Twin data permit decomposition of comorbidity into genetically and environmentally derived correlations. No previous twin study includes all major forms of anxiety disorder...
  89. pmc Epidemiology and symptomatology of depression in Sri Lanka: a cross-sectional population-based survey in Colombo District
    Harriet A Ball
    MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, SE5 8AF, UK
    J Affect Disord 123:188-96. 2010
    ..This study aimed to examine the characteristic features of depression in Sri Lanka, and to identify environmental risk factors...
  90. ncbi Genetic and environmental contributions to the Child Behavior Checklist Obsessive-Compulsive Scale: a cross-cultural twin study
    James J Hudziak
    Department of Psychiatry, University of Vermont, Burlington Vrije University, Amsterdam, The Netherlands
    Arch Gen Psychiatry 61:608-16. 2004
    ..Twin studies of obsessive-compulsive disorder have indicated a significant genetic component to its expression...
  91. pmc Neuroimaging of response interference in twins concordant or discordant for inattention and hyperactivity symptoms
    D van 't Ent
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
    Neuroscience 164:16-29. 2009
    ....
  92. ncbi Population-based family studies in genetic epidemiology
    John L Hopper
    University of Melbourne, Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, 723 Swanston Street, Carlton, Victoria 3053, Australia
    Lancet 366:1397-406. 2005
    ..Given their versatility, population-based family studies could become a principal framework in epidemiology, and move genetics from its traditional focus on high-risk families to give it a wider clinical and population health relevance...
  93. ncbi Twin studies of eating disorders: a review
    C M Bulik
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Int J Eat Disord 27:1-20. 2000
    ..Although twin studies are powerful tools, their methodology can be arcane and their implications easily misinterpreted...
  94. ncbi The genetic and environmental contributions to attention deficit hyperactivity disorder as measured by the Conners' Rating Scales--Revised
    James J Hudziak
    Division of Behavioral Genetics, Department of Psychiatry, University of Vermont, Given B229, Burlington, VT 05405, USA
    Am J Psychiatry 162:1614-20. 2005
    ..These studies typically used DSM ADHD symptoms collected by telephone or interviews with mothers. The purpose of this study was to test the genetic architecture of ADHD by using the ADHD index from Conners' Rating Scales-Revised...
  95. pmc Does zygosity influence the metabolic profile of twins? A population based cross sectional study
    P Poulsen
    Department of Endocrinology and Internal Medicine, Odense University Hospital, DK 5000 C Odense, Denmark
    BMJ 319:151-4. 1999
    ..To study the influence of zygosity on the metabolic variables involved in the pathophysiology of type 2 diabetes...
  96. ncbi Genetic influences in irritable bowel syndrome: a twin study
    Imtiyaz Mohammed
    Department of Gastroenterology, Sandwell General Hospital, West Bromwich, United Kingdom
    Am J Gastroenterol 100:1340-4. 2005
    ..This may be due to environmental factors, including learned responses to abdominal symptoms or a genetic contribution to the etiology of IBS...
  97. ncbi Do we need more twin studies? The Healthy Twin Study, Korea
    Joohon Sung
    Int J Epidemiol 35:488-90. 2006
  98. ncbi The effect of treatment of twin-twin transfusion syndrome on the diagnosis-to-delivery interval
    Daniel W Skupski
    New York Presbyterian Hospital Weill Cornell Center, USA
    Twin Res 5:1-4. 2002
    ..All TTTS series were included where the following information on each patient was available: survival, fetal demise, gestational age at diagnosis and diagnosis-to-delivery interval in days...
  99. ncbi Prevalence, heritability, and prospective risk factors for anorexia nervosa
    Cynthia M Bulik
    Department of Psychiatry, School of Public Health, University of North Carolina at Chapel Hill, 27599, USA
    Arch Gen Psychiatry 63:305-12. 2006
    ..Anorexia nervosa (AN) is a serious mental illness with marked morbidity and mortality...
  100. pmc Colombo Twin and Singleton Study (CoTASS): a description of a population based twin study of mental disorders in Sri Lanka
    Sisira H Siribaddana
    Sri Lanka Twin Registry, Institute of Research and Development, Battaramulla, Sri Lanka
    BMC Psychiatry 8:49. 2008
    ..This paper presents the rationale for the study, describes its context, and the methods for twin ascertainment and data collection...
  101. ncbi Low birthweight and Type 2 diabetes: a study on 11 162 Swedish twins
    A Iliadou
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Int J Epidemiol 33:948-53; discussion 953-4. 2004
    ..Method A cohort of 11 162 same-sexed Swedish twins born between 1906 and 1958 was used in order to investigate the risk of developing Type 2 diabetes between and within twin pairs by utilizing random effects linear models...

Research Grants146 found, 100 shown here

  1. TWIN-FAMILY STUDY OF DRUG USE, ABUSE, AND DEPENDENCE
    Kenneth Kendler; Fiscal Year: 2002
    ....
  2. THE GENETIC EPIDEMIOLOGY OF SCHIZOPHRENIA IN IRELAND
    Kenneth Kendler; Fiscal Year: 1993
    ....
  3. IRISH AFFECTED SIB PAIR STUDY OF ALCOHOL DEPENDENCE
    Kenneth Kendler; Fiscal Year: 2001
    ..Phenotypic analyses of the data will focus on detecting familial resemblance for symptoms, factors and typologies of AD to be used to define putative etiologic subtypes of AD for future linkage analyses. ..
  4. Axis I & Axis II Psychiatric Disorders in Norwegian Twin
    Kenneth Kendler; Fiscal Year: 2006
    ..This study has the capacity to address several key and largely unanswered empirical questions about PDs, the answers to which will be critical for proposed revisions in DSM-V. ..
  5. GENETIC EPIDEMIOLOGY OF SCHIZOPHRENIA IN IRELAND
    Kenneth Kendler; Fiscal Year: 2002
    ..5 to 1.0 centiMorgans and a cooperative, stable population make Ireland ideal for linkage disequilibrium studies of schizophrenia. ..
  6. THE GENETIC EPIDEMIOLOGY OF SCHIZOPHRENIA IN IRELAND
    Kenneth Kendler; Fiscal Year: 1990
    ....
  7. TWIN-FAMILY STUDY OF DRUG USE, ABUSE, AND DEPENDENCE
    Kenneth Kendler; Fiscal Year: 2000
    ....
  8. IRISH AFFECTED SIB PAIR STUDY OF ALCOHOL DEPENDENCE
    Kenneth Kendler; Fiscal Year: 2000
    ..Phenotypic analyses of the data will focus on detecting familial resemblance for symptoms, factors and typologies of AD to be used to define putative etiologic subtypes of AD for future linkage analyses. ..
  9. TWIN-FAMILY STUDY OF DRUG USE, ABUSE, AND DEPENDENCE
    Kenneth Kendler; Fiscal Year: 2001
    ....
  10. GENETIC EPIDEMIOLOGY OF SCHIZOPHRENIA IN IRELAND
    Kenneth Kendler; Fiscal Year: 2000
    ..5 to 1.0 centiMorgans and a cooperative, stable population make Ireland ideal for linkage disequilibrium studies of schizophrenia. ..
  11. THE GENETIC EPIDEMIOLOGY OF SCHIZOPHRENIA IN IRELAND
    Kenneth Kendler; Fiscal Year: 2005
    ..In this competitive renewal, we request 5 further years of support with the primary goals of identifying these pathogenic variant(s) and relating them to the biology of the gene, gene product and disease. ..
  12. TWIN-FAMILY STUDY OF DRUG USE, ABUSE, AND DEPENDENCE
    Kenneth Kendler; Fiscal Year: 1999
    ....
  13. The Epidemiology of Mood, Anxiety and Alcohol Disorder
    Kenneth Kendler; Fiscal Year: 2004
    ....
  14. Axis I & Axis II Psychiatric Disorders in Norwegian Twin
    Kenneth Kendler; Fiscal Year: 2004
    ..This study has the capacity to address several key and largely unanswered empirical questions about PDs, the answers to which will be critical for proposed revisions in DSM-V. ..
  15. THE GENETIC EPIDEMIOLOGY OF SCHIZOPHRENIA IN IRELAND
    Kenneth Kendler; Fiscal Year: 2004
    ..In this competitive renewal, we request 5 further years of support with the primary goals of identifying these pathogenic variant(s) and relating them to the biology of the gene, gene product and disease. ..
  16. A Twin-Family Study of Drug Use, Abuse, and Dependence
    Kenneth Kendler; Fiscal Year: 2006
    ..abstract_text> ..
  17. IRISH AFFECTED SIB PAIR STUDY OF ALCOHOL DEPENDENCE
    Kenneth Kendler; Fiscal Year: 1999
    ..Phenotypic analyses of the data will focus on detecting familial resemblance for symptoms, factors and typologies of AD to be used to define putative etiologic subtypes of AD for future linkage analyses. ..
  18. THE EPIDEMIOLOGY OF MOOD, ANXIETY AND ALCOHOL DISORDERS
    Kenneth Kendler; Fiscal Year: 1993
    ..We will develop multivariate genetic models including specified environmental risk factors that will provide realistic etiologic models for these disorders that incorporate all major risk factor domains...
  19. The Epidemiology of Mood, Anxiety and Alcohol Disorder
    Kenneth Kendler; Fiscal Year: 2003
    ....
  20. Axis I & Axis II Psychiatric Disorders in Norwegian Twin
    Kenneth Kendler; Fiscal Year: 2007
    ..This study has the capacity to address several key and largely unanswered empirical questions about PDs, the answers to which will be critical for proposed revisions in DSM-V. ..
  21. GENETIC EPIDEMIOLOGY OF SCHIZOPHRENIA IN IRELAND
    Kenneth Kendler; Fiscal Year: 2001
    ..5 to 1.0 centiMorgans and a cooperative, stable population make Ireland ideal for linkage disequilibrium studies of schizophrenia. ..
  22. The Epidemiology of Mood, Anxiety and Alcohol Disorder
    Kenneth Kendler; Fiscal Year: 2001
    ....
  23. A Twin-Family Study of Drug Use, Abuse, and Dependence
    Kenneth Kendler; Fiscal Year: 2005
    ..abstract_text> ..
  24. THE EPIDEMIOLOGY OF MOOD, ANXIETY AND ALCOHOL DISORDERS
    Kenneth Kendler; Fiscal Year: 1992
    ..We will develop multivariate genetic models including specified environmental risk factors that will provide realistic etiologic models for these disorders that incorporate all major risk factor domains...
  25. GENETIC EPIDEMIOLOGY OF SCHIZOPHRENIA IN IRELAND
    Kenneth Kendler; Fiscal Year: 1999
    ..5 to 1.0 centiMorgans and a cooperative, stable population make Ireland ideal for linkage disequilibrium studies of schizophrenia. ..
  26. EPIDEMIOLOGY OF MOOD, ANXIETY AND ALCOHOL DISORDERS
    Kenneth Kendler; Fiscal Year: 1999
    ..We will develop multivariate genetic models including specified environmental risk factors that will provide realistic etiologic models for these disorders that incorporate all major risk factor domains. ..
  27. The Epidemiology of Mood, Anxiety and Alcohol Disorder
    Kenneth Kendler; Fiscal Year: 2002
    ....
  28. THE GENETIC EPIDEMIOLOGY OF SCHIZOPHRENIA IN IRELAND
    Kenneth Kendler; Fiscal Year: 2008
    ..In this competitive renewal, we request 5 further years of support with the primary goals of identifying these pathogenic variant(s) and relating them to the biology of the gene, gene product and disease. ..
  29. THE GENETIC EPIDEMIOLOGY OF SCHIZOPHRENIA IN IRELAND
    Kenneth Kendler; Fiscal Year: 1992
    ....
  30. A Twin-Family Study of Drug Use, Abuse, and Dependence
    Kenneth Kendler; Fiscal Year: 2007
    ..abstract_text> ..
  31. TWIN-FAMILY STUDY OF DRUG USE, ABUSE, AND DEPENDENCE
    Kenneth Kendler; Fiscal Year: 2002
    ....
  32. TWIN-FAMILY STUDY OF DRUG USE, ABUSE, AND DEPENDENCE
    Kenneth Kendler; Fiscal Year: 2001
    ....
  33. THE GENETIC EPIDEMIOLOGY OF SCHIZOPHRENIA IN IRELAND
    Kenneth Kendler; Fiscal Year: 1991
    ....
  34. THE GENETIC EPIDEMIOLOGY OF SCHIZOPHRENIA IN IRELAND
    Kenneth Kendler; Fiscal Year: 2007
    ..In this competitive renewal, we request 5 further years of support with the primary goals of identifying these pathogenic variant(s) and relating them to the biology of the gene, gene product and disease. ..
  35. Axis I & Axis II Psychiatric Disorders in Norwegian Twin
    Kenneth Kendler; Fiscal Year: 2005
    ..This study has the capacity to address several key and largely unanswered empirical questions about PDs, the answers to which will be critical for proposed revisions in DSM-V. ..
  36. An Irish Affected Sib Pair Study of Alcohol Dependence
    Kenneth Kendler; Fiscal Year: 2005
    ..To conduct this project we have assembled a team of experts in clinical assessment, statistical genetics and molecular genetics...
  37. THE GENETIC EPIDEMIOLOGY OF SCHIZOPHRENIA IN IRELAND
    Kenneth Kendler; Fiscal Year: 2006
    ..In this competitive renewal, we request 5 further years of support with the primary goals of identifying these pathogenic variant(s) and relating them to the biology of the gene, gene product and disease. ..
  38. TWIN-FAMILY STUDY OF DRUG USE, ABUSE, AND DEPENDENCE
    Kenneth Kendler; Fiscal Year: 2001
    ....
  39. An Alcohol Affected Sib Pair Study of Alcohol Dependence
    Kenneth Kendler; Fiscal Year: 2008
    ....
  40. Integrating contextual, proximal, and individual risks for child conduct problems
    S Alexandra Burt; Fiscal Year: 2010
    ..Such findings should ultimately inform individually-tailored interventions aimed at the amelioration of child CP. ..
  41. Gene-environment Interactions in Childhood Conduct Problems
    S Burt; Fiscal Year: 2008
    ..Such findings should ultimately provide information for more effective individually-tailored interventions aimed at the amelioration of child CP. ..
  42. Gene-environment Interactions in Childhood Conduct Problems
    S Burt; Fiscal Year: 2009
    ..Such findings should ultimately provide information for more effective individually-tailored interventions aimed at the amelioration of child CP. ..
  43. Gene-environment Interactions in Childhood Conduct Problems
    S Alexandra Burt; Fiscal Year: 2010
    ..Such findings should ultimately provide information for more effective individually-tailored interventions aimed at the amelioration of child CP. ..
  44. Heritability of Transitions in Women's Alcohol Use/Dependence
    Carolyn Sartor; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  45. DEMENTIA IN SWEDISH TWINS
    Margaret Gatz; Fiscal Year: 1999
    ..Different diagnostic criteria will be compared. Quantitative indices will be derived from neuropsychological scores and from neuroimaging data subjected to quantitative mapping. ..
  46. DEMENTIA IN SWEDISH TWINS
    Margaret Gatz; Fiscal Year: 1992
    ..The Swedish sample provides a special research opportunity to achieve these purposes...
  47. DEMENTIA IN SWEDISH TWINS
    Margaret Gatz; Fiscal Year: 1990
    ....
  48. Genetic Predictors of Comorbid Depressive Symptoms + CAD
    Jeanne McCaffery; Fiscal Year: 2005
    ....
  49. SES, health behaviors and CVD among Vietnam-era-Twins
    Jeanne McCaffery; Fiscal Year: 2005
    ..The primary method of analysis will be twin structural equation modeling. ..
  50. SES, health behaviors and CVD among Vietnam-era-Twins
    Jeanne McCaffery; Fiscal Year: 2004
    ..The primary method of analysis will be twin structural equation modeling. ..
  51. A twin study of ovarian hormones and disordered eating
    Kelly Klump; Fiscal Year: 2009
    ..Greater insight into neurobiological mechanisms will narrow the search for candidate genes and contribute to improved treatment and prevention of these disorders. ..
  52. Genetic Epidemiology of Pathological Gambling
    Wendy Slutske; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  53. Genetic Epidemiology of Pathological Gambling
    Wendy Slutske; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  54. A twin study of ovarian hormones and disordered eating
    Kelly L Klump; Fiscal Year: 2010
    ..Greater insight into neurobiological mechanisms will narrow the search for candidate genes and contribute to improved treatment and prevention of these disorders. ..
  55. A twin study of ovarian hormones and disordered eating
    Kelly Klump; Fiscal Year: 2009
    ..Greater insight into neurobiological mechanisms will narrow the search for candidate genes and contribute to improved treatment and prevention of these disorders. ..
  56. A twin study of ovarian hormones and disordered eating
    Kelly Klump; Fiscal Year: 2008
    ..Greater insight into neurobiological mechanisms will narrow the search for candidate genes and contribute to improved treatment and prevention of these disorders. ..
  57. Genetic Epidemiology of Pathological Gambling
    Wendy Slutske; Fiscal Year: 2005
    ....
  58. Genetic and Environmental Risk for Eating Disorders
    Kelly Klump; Fiscal Year: 2003
    ..Findings from this study will significantly increase understanding of developmental risk factors for eating disorders and potentially inform intervention and prevention efforts aimed at their amelioration. ..
  59. Genetic Epidemiology of Pathological Gambling
    Wendy Slutske; Fiscal Year: 2004
    ....
  60. The Effects of Estradiol on Genetic Risk for Disordered Eating During Puberty
    Kelly L Klump; Fiscal Year: 2010
    ..Greater insight into neurobiological factors that contribute to these genetic effects will narrow the search for candidate genes and ultimately contribute to improved treatment and prevention of these disorders. ..
  61. Genetic Epidemiology of Pathological Gambling
    Wendy Slutske; Fiscal Year: 2003
    ....
  62. Familial Transmission of Eating Pathology & Sex Hormones
    Kelly Klump; Fiscal Year: 2002
    ..abstract_text> ..
  63. Mechanisms Linking Depression to Cardiovascular Risk
    L Vaccarino; Fiscal Year: 2002
    ..Besides extending our knowledge of the mechanisms linking depression to CVD risk, the findings of this project will help in the design of more effective approaches to the primary prevention of CVD. ..
  64. Mechanisms Linking Depression to Cardiovascular Risk
    L Vaccarino; Fiscal Year: 2003
    ..Besides extending our knowledge of the mechanisms linking depression to CVD risk, the findings of this project will help in the design of more effective approaches to the primary prevention of CVD. ..
  65. Mind-Body Interactions in Cardiosvascular Disease
    Viola Vaccarino; Fiscal Year: 2008
    ..abstract_text> ..
  66. Posttraumatic Stress Disorder and Cardiovascular Disease
    L Vaccarino; Fiscal Year: 2006
    ..Efforts toward the prevention, early identification and treatment of PTSD and the identification of factors that mediate its adverse effects could reduce morbidity and mortality from CVD. ..
  67. Mechanisms Linking Depression to Cardiovascular Risk
    Viola Vaccarino; Fiscal Year: 2009
    ..abstract_text> ..
  68. Posttraumatic Stress Disorder and Cardiovascular Disease
    Viola Vaccarino; Fiscal Year: 2007
    ..Efforts toward the prevention, early identification and treatment of PTSD and the identification of factors that mediate its adverse effects could reduce morbidity and mortality from CVD. ..
  69. Posttraumatic Stress Disorder and Cardiovascular Disease
    L Vaccarino; Fiscal Year: 2005
    ..Efforts toward the prevention, early identification and treatment of PTSD and the identification of factors that mediate its adverse effects could reduce morbidity and mortality from CVD. ..
  70. Electrophysiology and Neurocognition in Schizophrenia
    Peter Bachman; Fiscal Year: 2004
    ..abstract_text> ..
  71. Posttraumatic Stress Disorder and Cardiovascular Disease
    L Vaccarino; Fiscal Year: 2004
    ..Efforts toward the prevention, early identification and treatment of PTSD and the identification of factors that mediate its adverse effects could reduce morbidity and mortality from CVD. ..
  72. Mechanisms Linking Depression to Cardiovascular Risk
    L Vaccarino; Fiscal Year: 2001
    ..Besides extending our knowledge of the mechanisms linking depression to CVD risk, the findings of this project will help in the design of more effective approaches to the primary prevention of CVD. ..
  73. Depression as a Risk Factor for Dementia
    JESSICA BROMMELHOFF; Fiscal Year: 2007
    ..2006, p. 130). ..
  74. Mechanisms Linking Depression to Cardiovascular Risk
    Viola Vaccarino; Fiscal Year: 2010
    ..abstract_text> ..
  75. Biological Factors for Age-Related Macular Degeneration
    Johanna Seddon; Fiscal Year: 2003
    ..abstract_text> ..
  76. Biomarkers for Psychosis in Velocardiofacial Syndrome
    Wendy Kates; Fiscal Year: 2007
    ....
  77. SUBSTANCE ABUSE AND THE DOPAMINE SYSTEM GENES
    Michael Vanyukov; Fiscal Year: 2000
    ..The results will allow for more accurate estimation of the risk for SUD and suggest approaches for prevention. ..
  78. Phenogenetics of Liability to Substance Use Disorders
    Michael Vanyukov; Fiscal Year: 2007
    ..The applicant is the Center's Co-Pi and Scientific Director as well as PI of the CGS project. ..
  79. Mind-Body Interactions in Cardiosvascular Disease
    Viola Vaccarino; Fiscal Year: 2007
    ..abstract_text> ..
  80. Biological Factors for Age-Related Macular Degeneration
    Johanna Seddon; Fiscal Year: 2002
    ..abstract_text> ..
  81. Genetic Epidemiology of Eating Disordered Behavior
    Suzanne Mazzeo; Fiscal Year: 2008
    ..It will also provide Dr. Mazzeo with the requisite training to become an independent investigator in the genetic epidemiology of eating disorders. ..
  82. Mental Health Services in NY after WTC Disaster
    Joseph Boscarino; Fiscal Year: 2002
    ..abstract_text> ..