dehydration

Summary

Summary: The condition that results from excessive loss of water from a living organism.

Top Publications

  1. ncbi Assessing hydration status: the elusive gold standard
    Lawrence E Armstrong
    Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, CT 06269 1110, USA
    J Am Coll Nutr 26:575S-584S. 2007
  2. pmc Isolation and functional analysis of Arabidopsis stress-inducible NAC transcription factors that bind to a drought-responsive cis-element in the early responsive to dehydration stress 1 promoter
    Lam Son Phan Tran
    Biological Resources Division, Japan International Research Center for Agricultural Sciences, Tsukuba, Ibaraki 305 8686, Japan
    Plant Cell 16:2481-98. 2004
  3. pmc Photosynthesis under drought and salt stress: regulation mechanisms from whole plant to cell
    M M Chaves
    Instituto Superior de Agronomia, Technical University of Lisbon, Lisbon, Portugal
    Ann Bot 103:551-60. 2009
  4. pmc Genome-wide survey and expression analysis of the plant-specific NAC transcription factor family in soybean during development and dehydration stress
    Dung Tien Le
    Signaling Pathway Research Unit, Plant Science Center, RIKEN Yokohama Institute, Suehiro cho, Tsurumi, Japan
    DNA Res 18:263-76. 2011
  5. ncbi Interaction between two cis-acting elements, ABRE and DRE, in ABA-dependent expression of Arabidopsis rd29A gene in response to dehydration and high-salinity stresses
    Yoshihiro Narusaka
    Biological Resources Division, Japan International Research Center for Agricultural Sciences JIRCAS, 1 1 Ohwashi, Tsukuba, Ibaraki 305 8686, Japan
    Plant J 34:137-48. 2003
  6. pmc Identification of cis-acting promoter elements in cold- and dehydration-induced transcriptional pathways in Arabidopsis, rice, and soybean
    Kyonoshin Maruyama
    Biological Resources and Post harvest Division, Japan International Research Center for Agricultural Sciences, Tsukuba, Ibaraki 305 8686, Japan
    DNA Res 19:37-49. 2012
  7. pmc Transcriptional profiles of drought-responsive genes in modulating transcription signal transduction, and biochemical pathways in tomato
    Pengjuan Gong
    National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China
    J Exp Bot 61:3563-75. 2010
  8. ncbi Hydration assessment techniques
    Lawrence E Armstrong
    Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Unit 1110, 2095 Hillside Road, Storrs, CT 06269 1110, USA
    Nutr Rev 63:S40-54. 2005
  9. ncbi Characterization of the ABA-regulated global responses to dehydration in Arabidopsis by metabolomics
    Kaoru Urano
    Gene Discovery Research Group, RIKEN Plant Science Center, 3 1 1 Koyadai, Tsukuba, Ibaraki, Japan
    Plant J 57:1065-78. 2009
  10. ncbi Biological variation and diagnostic accuracy of dehydration assessment markers
    Samuel N Cheuvront
    US Army Research Institute of Environmental Medicine, Natick, MA 01760 5007, USA
    Am J Clin Nutr 92:565-73. 2010

Detail Information

Publications386 found, 100 shown here

  1. ncbi Assessing hydration status: the elusive gold standard
    Lawrence E Armstrong
    Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, CT 06269 1110, USA
    J Am Coll Nutr 26:575S-584S. 2007
    ....
  2. pmc Isolation and functional analysis of Arabidopsis stress-inducible NAC transcription factors that bind to a drought-responsive cis-element in the early responsive to dehydration stress 1 promoter
    Lam Son Phan Tran
    Biological Resources Division, Japan International Research Center for Agricultural Sciences, Tsukuba, Ibaraki 305 8686, Japan
    Plant Cell 16:2481-98. 2004
    The MYC-like sequence CATGTG plays an important role in the dehydration-inducible expression of the Arabidopsis thaliana EARLY RESPONSIVE TO DEHYDRATION STRESS 1 (ERD1) gene, which encodes a ClpA (ATP binding subunit of the caseinolytic ..
  3. pmc Photosynthesis under drought and salt stress: regulation mechanisms from whole plant to cell
    M M Chaves
    Instituto Superior de Agronomia, Technical University of Lisbon, Lisbon, Portugal
    Ann Bot 103:551-60. 2009
    ..Photosynthesis, together with cell growth, is among the primary processes to be affected by water or salt stress...
  4. pmc Genome-wide survey and expression analysis of the plant-specific NAC transcription factor family in soybean during development and dehydration stress
    Dung Tien Le
    Signaling Pathway Research Unit, Plant Science Center, RIKEN Yokohama Institute, Suehiro cho, Tsurumi, Japan
    DNA Res 18:263-76. 2011
    ..identified 58 of the 152 GmNACs as putative stress-responsive genes, including eight previously reported dehydration-responsive GmNACs...
  5. ncbi Interaction between two cis-acting elements, ABRE and DRE, in ABA-dependent expression of Arabidopsis rd29A gene in response to dehydration and high-salinity stresses
    Yoshihiro Narusaka
    Biological Resources Division, Japan International Research Center for Agricultural Sciences JIRCAS, 1 1 Ohwashi, Tsukuba, Ibaraki 305 8686, Japan
    Plant J 34:137-48. 2003
    Many abiotic stress-inducible genes contain two cis-acting elements, namely a dehydration-responsive element (DRE; TACCGACAT) and an ABA-responsive element (ABRE; ACGTGG/TC), in their promoter regions...
  6. pmc Identification of cis-acting promoter elements in cold- and dehydration-induced transcriptional pathways in Arabidopsis, rice, and soybean
    Kyonoshin Maruyama
    Biological Resources and Post harvest Division, Japan International Research Center for Agricultural Sciences, Tsukuba, Ibaraki 305 8686, Japan
    DNA Res 19:37-49. 2012
    ..In Arabidopsis, cis-acting promoter elements involved in cold- and dehydration-responsive gene expression have been extensively analysed; however, the characteristics of such cis-acting ..
  7. pmc Transcriptional profiles of drought-responsive genes in modulating transcription signal transduction, and biochemical pathways in tomato
    Pengjuan Gong
    National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China
    J Exp Bot 61:3563-75. 2010
    ..The drought-responsive genes identified in this study could provide further information for understanding the mechanisms of drought tolerance in tomato...
  8. ncbi Hydration assessment techniques
    Lawrence E Armstrong
    Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Unit 1110, 2095 Hillside Road, Storrs, CT 06269 1110, USA
    Nutr Rev 63:S40-54. 2005
    ..It also provides guidance for selecting techniques that are appropriate for use with unique individuals and situations...
  9. ncbi Characterization of the ABA-regulated global responses to dehydration in Arabidopsis by metabolomics
    Kaoru Urano
    Gene Discovery Research Group, RIKEN Plant Science Center, 3 1 1 Koyadai, Tsukuba, Ibaraki, Japan
    Plant J 57:1065-78. 2009
    ..Adaptation by plants to dehydration stress is a complex biological process that involves global changes in gene expression and metabolite ..
  10. ncbi Biological variation and diagnostic accuracy of dehydration assessment markers
    Samuel N Cheuvront
    US Army Research Institute of Environmental Medicine, Natick, MA 01760 5007, USA
    Am J Clin Nutr 92:565-73. 2010
    Well-recognized markers for static (one time) or dynamic (monitoring over time) dehydration assessment have not been rigorously tested for their usefulness in clinical, military, and sports medicine communities.
  11. ncbi Saliva parameters as potential indices of hydration status during acute dehydration
    Neil P Walsh
    School of Sport, Health and Exercise Sciences, University of Wales, Bangor, United Kingdom
    Med Sci Sports Exerc 36:1535-42. 2004
    ..of hydration, we compared changes in these parameters with changes in plasma osmolality during progressive dehydration. Secondly, we compared the sensitivity of saliva parameters to track hydration changes with the sensitivity of ..
  12. pmc RhNAC2 and RhEXPA4 are involved in the regulation of dehydration tolerance during the expansion of rose petals
    Fanwei Dai
    Department of Ornamental Horticulture, China Agricultural University, Haidian, Beijing 100193, China
    Plant Physiol 160:2064-82. 2012
    b>Dehydration inhibits petal expansion resulting in abnormal flower opening and results in quality loss during the marketing of cut flowers...
  13. pmc Dual function of an Arabidopsis transcription factor DREB2A in water-stress-responsive and heat-stress-responsive gene expression
    Yoh Sakuma
    Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113 8657, Japan
    Proc Natl Acad Sci U S A 103:18822-7. 2006
    Transcription factor DREB2A interacts with a cis-acting dehydration-responsive element (DRE) sequence and activates expression of downstream genes involved in drought- and salt-stress response in Arabidopsis thaliana...
  14. ncbi Is this child dehydrated?
    Michael J Steiner
    Department of Pediatrics, University of North Carolina School of Medicine, and Robert Wood Johnson Clinical Scholars Program, Chapel Hill 27599 7593, USA
    JAMA 291:2746-54. 2004
    The ability to assess the degree of dehydration quickly and accurately in infants and young children often determines patient treatment and disposition.
  15. ncbi Identification of drought-induced microRNAs in rice
    Botao Zhao
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai 200031, China
    Biochem Biophys Res Commun 354:585-90. 2007
    ..Sequence analysis revealed occurrence of two proximate DREs (dehydration-responsive element) in the upstream of the MIR-169g, suggesting that miR-169g expression may be regulated ..
  16. pmc The role of plasma membrane intrinsic protein aquaporins in water transport through roots: diurnal and drought stress responses reveal different strategies between isohydric and anisohydric cultivars of grapevine
    Rebecca K Vandeleur
    School of Agriculture, Food, and Wine, University of Adelaide, Waite Campus, Urrbrae, South Australia 5064, Australia
    Plant Physiol 149:445-60. 2009
    ..This occurs on a diurnal basis and in response to water stress that corresponds to the difference in drought tolerance between the cultivars...
  17. ncbi Human hydration indices: acute and longitudinal reference values
    Lawrence E Armstrong
    Human Performance Laboratory, University of Connecticut, Storrs, CT, USA
    Int J Sport Nutr Exerc Metab 20:145-53. 2010
    ..These findings provide euhydration reference values and hydration extremes for 7 commonly used indices in free-living, healthy, active men who were not exercising in a hot environment or training strenuously...
  18. pmc Expression of StMYB1R-1, a novel potato single MYB-like domain transcription factor, increases drought tolerance
    Dongjin Shin
    Bio crop Development Division, National Academy of Agricultural Science, Rural Development Administration, Suwon 441 857, Republic of Korea
    Plant Physiol 155:421-32. 2011
    ..Thus, the expression of StMYB1R-1 in potato enhanced drought tolerance via regulation of water loss. These results indicated that StMYB1R-1 functions as a transcription factor involved in the activation of drought-related genes...
  19. ncbi Reference change values for monitoring dehydration
    Samuel N Cheuvront
    U S Army Research Institute of Environmental Medicine, Thermal and Mountain Medicine Division, Natick, MA 01760 5007, USA
    Clin Chem Lab Med 49:1033-7. 2011
    b>Dehydration is a common medical problem requiring heuristic evaluation...
  20. pmc Chemical clearing and dehydration of GFP expressing mouse brains
    Klaus Becker
    Department of Bioelectronics, Vienna University of Technology, FKE, Vienna, Austria
    PLoS ONE 7:e33916. 2012
    ..Chemical clearing, staining, and embedding of biological samples mostly requires careful foregoing tissue dehydration. The commonly applied tissue dehydration medium is ethanol, which also can markedly impair GFP fluorescence...
  21. pmc Characterization of the promoter region of an Arabidopsis gene for 9-cis-epoxycarotenoid dioxygenase involved in dehydration-inducible transcription
    Babak Behnam
    Gene Discovery Research Group, RIKEN Center for Sustainable Resource Science, 3 1 1 Koyadai, Tsukuba 305 0074, Japan
    DNA Res 20:315-24. 2013
    Plants respond to dehydration stress and tolerate water-deficit status through complex physiological and cellular processes. Many genes are induced by water deficit...
  22. pmc Role of the putative osmosensor Arabidopsis histidine kinase1 in dehydration avoidance and low-water-potential response
    M Nagaraj Kumar
    Institute of Plant and Microbial Biology, Academia Sinica, Taipei 11529, Taiwan
    Plant Physiol 161:942-53. 2013
    ..The unimpaired growth, ABA, proline, and solute accumulation of ahk1 mutants at low ψ(w) suggest that AHK1 may not be the main plant osmosensor required for low ψ(w) tolerance...
  23. ncbi Effects of athletes' muscle mass on urinary markers of hydration status
    Nassim Hamouti
    Exercise Physiology Laboratory at Toledo, University of Castilla La Mancha, Avda Carlos III, S N, 45071 Toledo, Spain
    Eur J Appl Physiol 109:213-9. 2010
    ..Our data suggest that athletes with large muscle mass (i.e., rugby players) are prone to be incorrectly classified as hypohydrated based on U(sg)...
  24. pmc The physiology and proteomics of drought tolerance in maize: early stomatal closure as a cause of lower tolerance to short-term dehydration?
    Monika Benesova
    Department of Genetics and Microbiology, Faculty of Science, Charles University in Prague, Prague, Czech Republic
    PLoS ONE 7:e38017. 2012
    ..In our study, two maize (Zea mays L.) genotypes with contrasting sensitivity to dehydration were subjected to moderate drought conditions...
  25. ncbi Analysis of the nuclear proteome of the resurrection plant Xerophyta viscosa in response to dehydration stress using iTRAQ with 2DLC and tandem mass spectrometry
    Kamal Omer Abdalla
    Department of Molecular and Cellular Biology, University of Cape Town, Private Bag, Rondebosch 7701, South Africa
    J Proteomics 75:2361-74. 2012
    Xerophyta viscosa Baker (family Velloziaceae) is a desiccation tolerant plant which survives extremes of dehydration down to 5% relative water content (RWC) and resumes full physiological activity within 80h of rehydration...
  26. ncbi Effect of exercise-induced dehydration on time-trial exercise performance: a meta-analysis
    Eric D B Goulet
    Research Centre on Aging Faculty of Physical Education and Sports, University of Sherbrooke, Quebec, Canada
    Br J Sports Med 45:1149-56. 2011
    To use the meta-analytical procedures to determine the magnitude of the effect of exercise-induced dehydration (EID) upon time-trial (TT) exercise performance.
  27. ncbi ATriple Iron triathlon leads to a decrease in total body mass but not to dehydration
    Beat Knechtle
    St Gallen Health Center, St Gallen, Switzerland
    Res Q Exerc Sport 81:319-27. 2010
    A loss in total body mass during an ultraendurance performance is usually attributed to dehydration. We identified the changes in total body mass, fat mass, skeletal muscle mass, and selected markers of hydration status in 31 male ..
  28. pmc Dynamic changes in genome-wide histone H3 lysine 4 methylation patterns in response to dehydration stress in Arabidopsis thaliana
    Karin van Dijk
    Center for Biotechnology, University of Nebraska, Lincoln, NE 68588, USA
    BMC Plant Biol 10:238. 2010
    ..We have no knowledge of chromatin modifications taking place at genes whose transcription has been down-regulated or on the genome-wide chromatin modification patterns that occur during the plant's response to dehydration stress.
  29. pmc Heat shock proteins contribute to mosquito dehydration tolerance
    Joshua B Benoit
    Department of Entomology, The Ohio State University, Columbus, OH 43210, United States
    J Insect Physiol 56:151-6. 2010
    This study examines the responses of heat shock protein transcripts, Hsp70 and Hsp90, to dehydration stress in three mosquito species, Aedes aegypti, Anopheles gambiae and Culex pipiens...
  30. ncbi Role of ABA and ABI3 in desiccation tolerance
    A Khandelwal
    Monsanto Company, 700 Chesterfield Parkway West, St Louis, MO 63017, USA
    Science 327:546. 2010
    ..When their expression was compared with that of DeltaPpabi3 during ABA pretreatment and immediately after desiccation, a new target of ABI3 action appears to be in the recovery period...
  31. pmc The crucial role of plant mitochondria in orchestrating drought tolerance
    Owen K Atkin
    Research School of Biological Sciences, Australian National University, Canberra, Australia
    Ann Bot 103:581-97. 2009
    ..In contrast to the large number of studies assessing drought impacts on photosynthesis, relatively little attention has been devoted to understanding how mitochondrial respiratory metabolism is altered under water stress conditions...
  32. ncbi Molecular characterization of stress-inducible GmNAC genes in soybean
    Lam Son Phan Tran
    Division of Plant Sciences, National Center for Soybean Biotechnology, University of Missouri, Columbia, MO 65211, USA
    Mol Genet Genomics 281:647-64. 2009
    ..we prescreened and re-confirmed by quantitative real-time PCR analysis that nine GmNAC genes are induced by dehydration stress with differential induction levels in both shoot and root...
  33. pmc Causes of decreased photosynthetic rate and metabolic capacity in water-deficient leaf cells: a critical evaluation of mechanisms and integration of processes
    David W Lawlor
    Plant Sciences, Centre for Crop Improvement, Rothamsted Research, Harpenden, Herts, UK
    Ann Bot 103:561-79. 2009
    ..The relative importance of g(s) and A(pot), and how they are affected by WD, are reviewed with respect to light intensity and to experimental approaches...
  34. ncbi Regulation of barley miRNAs upon dehydration stress correlated with target gene expression
    Melda Kantar
    Biological Sciences and Bioengineering Program, Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, Turkey
    Funct Integr Genomics 10:493-507. 2010
    We aim to identify conserved and dehydration responsive microRNAs (miRNAs) in Hordeum vulgare (barley). A total of 28 new barley miRNAs belonging to 18 distinct miRNA families were identified...
  35. ncbi Cryptobiosis--a peculiar state of biological organization
    J S Clegg
    Bodega Marine Laboratory and Molecular and Cellular Biology, University of California Davis, Bodega Bay, CA 94923, USA
    Comp Biochem Physiol B Biochem Mol Biol 128:613-24. 2001
    ..Basic research on cryptobiosis has resulted in unpredicted applications that are of substantial benefit to the human condition and a few of these are described briefly...
  36. pmc Airway and lung pathology due to mucosal surface dehydration in {beta}-epithelial Na+ channel-overexpressing mice: role of TNF-{alpha} and IL-4R{alpha} signaling, influence of neonatal development, and limited efficacy of glucocorticoid treatment
    Alessandra Livraghi
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, 27599, USA
    J Immunol 182:4357-67. 2009
    ..Thus, manipulation of multiple pathways will likely be required to treat the complex pathogenesis caused by airway surface dehydration.
  37. pmc The Citrus ABA signalosome: identification and transcriptional regulation during sweet orange fruit ripening and leaf dehydration
    Paco Romero
    Instituto de Agroquimica y Tecnologia de Alimentos IATA CSIC, Consejo Superior de Investigaciones Cientificas, Av Agustín Escardino, 7, 46980, Paterna Valencia, Spain
    J Exp Bot 63:4931-45. 2012
    ..Transcriptional changes in the ABA signalosome during leaf dehydration were also studied...
  38. ncbi Interaction of proline, sugars, and anthocyanins during photosynthetic acclimation of Arabidopsis thaliana to drought stress
    Ilektra Sperdouli
    Department of Botany, School of Biology, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece
    J Plant Physiol 169:577-85. 2012
    ....
  39. ncbi A novel cold-inducible gene from Pak-choi (Brassica campestris ssp. chinensis), BcWRKY46, enhances the cold, salt and dehydration stress tolerance in transgenic tobacco
    Feng Wang
    State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing, 210095, People s Republic of China
    Mol Biol Rep 39:4553-64. 2012
    ..quickly and strongly in response to various environmental stresses, including low temperatures, ABA, salt and dehydration. Constitutive expression of BcWRKY46 in tobacco under the control of the CaMV35S promoter reduced the ..
  40. ncbi Human water needs
    Michael N Sawka
    Thermal and Mountain Medicine Division, US Army Research Institute of Environmental Medicine, Natick, MA 01760 5007, USA
    Nutr Rev 63:S30-9. 2005
    ..7 L for adult women meets the needs of the vast majority of persons. However, strenuous physical exercise and heat stress can greatly increase daily water needs, and the individual variability between athletes can be substantial...
  41. ncbi Over-expression of OsDREB genes lead to enhanced drought tolerance in rice
    Jian Qiang Chen
    College of Life Sciences, Beijing Normal University, Beijing, 100875, People s Republic of China
    Biotechnol Lett 30:2191-8. 2008
    ....
  42. pmc Atypical epigenetic mark in an atypical location: cytosine methylation at asymmetric (CNN) sites within the body of a non-repetitive tomato gene
    Rodrigo M González
    Departamento de Fisiologia, Biologia Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires e IFIByNE CONICET, Buenos Aires, Argentina
    BMC Plant Biol 11:94. 2011
    ..We are particularly interested in investigating the epigenetics of plant species with larger and more complex genomes than Arabidopsis, particularly with regards to the associated alterations elicited by abiotic stress...
  43. ncbi Mechanisms of aerobic performance impairment with heat stress and dehydration
    Samuel N Cheuvront
    US Army Research Institute of Environmental Medicine, Thermal and Mountain Medicine Division, Kansas St, Natick, MA 01760 5007, USA
    J Appl Physiol (1985) 109:1989-95. 2010
    ..When dehydration exceeds 3% of total body water (2% of body mass) then aerobic performance is consistently impaired independent ..
  44. ncbi Cystic fibrosis: a disease of vulnerability to airway surface dehydration
    Richard C Boucher
    Cystic Fibrosis Pulmonary Research and Treatment Center and the UNC Virtual Lung Group, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Trends Mol Med 13:231-40. 2007
    ..Recent data suggest that CF lung disease pathogenesis reflects the vulnerability of airway surfaces to dehydration and collapse of mucus clearance...
  45. ncbi Dehydration and rehydration in competative sport
    R J Maughan
    School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK
    Scand J Med Sci Sports 20:40-7. 2010
    b>Dehydration, if sufficiently severe, impairs both physical and mental performance, and performance decrements are greater in hot environments and in long-lasting exercise...
  46. ncbi Effect of exercise, heat stress, and hydration on immune cell number and function
    Joel B Mitchell
    Exercise Physiology Laboratory, Department of Kinesiology, Texas Christian University, Fort Worth, TX, USA
    Med Sci Sports Exerc 34:1941-50. 2002
    ..The purpose of this study was to determine the effect of thermal stress and hydration status on immune function during exercise...
  47. ncbi Cloning and characterization of two 9-cis-epoxycarotenoid dioxygenase genes, differentially regulated during fruit maturation and under stress conditions, from orange (Citrus sinensis L. Osbeck)
    Maria Jesus Rodrigo
    Instituto de Agroquimica y Tecnologia de Alimentos IATA CSIC, Apartado de Correos 73, 46100 Burjassot, Valencia, Spain
    J Exp Bot 57:633-43. 2006
    ..Based on these results, it is suggested that 9-cis-violaxanthin may be the predominant substrate for NCED in the peel of Citrus fruits, whereas 9'-cis-neoxanthin would be the precursor of ABA in photosynthetic tissues...
  48. pmc Analysis of natural variation in bermudagrass (Cynodon dactylon) reveals physiological responses underlying drought tolerance
    Haitao Shi
    Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, China
    PLoS ONE 7:e53422. 2012
    ..Taken together, our results indicated that natural variation of drought stress tolerance in bermudagrass varieties might be largely related to the induced changes of water status, osmolyte accumulation and antioxidant defense system...
  49. ncbi Ion transport pathology in the mechanism of sickle cell dehydration
    Virgilio L Lew
    Physiological Laboratory, University of Cambridge, United Kingdom
    Physiol Rev 85:179-200. 2005
    ..reticulocyte homeostasis led to the formulation of an alternative to prevailing gradualist views: a multitrack dehydration model based on interactive influences between the red cell anion exchanger and two K(+) transporters, the ..
  50. pmc Four distinct types of dehydration stress memory genes in Arabidopsis thaliana
    Yong Ding
    University of Nebraska School of Biological Sciences, 1901 Vine Street, Lincoln 68588, USA
    BMC Plant Biol 13:229. 2013
    How plants respond to dehydration stress has been extensively researched. However, how plants respond to multiple consecutive stresses is virtually unknown...
  51. pmc Proteomic and selected metabolite analysis of grape berry tissues under well-watered and water-deficit stress conditions
    Jerome Grimplet
    Department of Biochemistry and Molecular Biology, University of Nevada Reno, Reno, NV 89557 0200, USA
    Proteomics 9:2503-28. 2009
    ..These results provide novel insights into the likely tissue-specific origins and the influence of water-deficit stress on the accumulation of key flavor and aroma compounds in wine...
  52. pmc Dehydration-responsive nuclear proteome of rice (Oryza sativa L.) illustrates protein network, novel regulators of cellular adaptation, and evolutionary perspective
    Mani Kant Choudhary
    National Institute of Plant Genome Research, New Delhi, India
    Mol Cell Proteomics 8:1579-98. 2009
    Water deficit or dehydration is the most crucial environmental constraint on plant growth and development and crop productivity...
  53. ncbi Effect of water deprivation on cognitive-motor performance in healthy men and women
    Gabor Szinnai
    Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Internal Medicine, University Hospital, CH 4031 Basel, Switzerland
    Am J Physiol Regul Integr Comp Physiol 289:R275-80. 2005
    Whether mental performance is affected by slowly progressive moderate dehydration induced by water deprivation has not been examined previously...
  54. pmc Investigating structural brain changes of dehydration using voxel-based morphometry
    Daniel Paolo Streitbürger
    Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
    PLoS ONE 7:e44195. 2012
    b>Dehydration can affect the volume of brain structures, which might imply a confound in volumetric and morphometric studies of normal or diseased brain...
  55. pmc Influence of hydration on physiological function and performance during trail running in the heat
    Douglas J Casa
    Department of Kinesiology, University of Connecticut, Storrs, CT 06269 1110, USA
    J Athl Train 45:147-56. 2010
    ..of most field studies have not observed decrements in physiologic function and performance with increases in dehydration, although authors of well-controlled laboratory studies have consistently reported this relationship...
  56. pmc Pharmacological inhibition of calpain-1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease
    Lucia De Franceschi
    Department of Medicine, University of Verona, Verona, Italy
    FASEB J 27:750-9. 2013
    ..BDA-410 prevented hypoxia-induced RBC dehydration and K(+) loss in SAD mice...
  57. ncbi Mild dehydration, vasopressin and the kidney: animal and human studies
    N Bouby
    INSERM U 367, Paris, France
    Eur J Clin Nutr 57:S39-46. 2003
    Water balance depends essentially on fluid intake and urine excretion. Mild dehydration and the consequent hypertonicity of the extracellular fluid induce an increase in vasopressin secretion, thus stimulating urine concentrating ..
  58. pmc Nuclear import and dimerization of tomato ASR1, a water stress-inducible protein exclusive to plants
    Martiniano M Ricardi
    Instituto de Fisiologia, Biología Molecular y Neurociencias IFIBYNE CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
    PLoS ONE 7:e41008. 2012
    ..The presence of dimers was further corroborated by means of in vivo crosslinking of nuclei followed by SDS-PAGE...
  59. ncbi Dehydration and cognitive performance
    Ann C Grandjean
    The Center for Human Nutrition, Room 1024 505 Durham Research Plaza, Omaha, Nebraska 68105, USA
    J Am Coll Nutr 26:549S-554S. 2007
    ..The use of neuropsychological assessment tools in assessing potential effects of dehydration is a natural progression of the scientific pursuit to understand the physical and mental ramifications of ..
  60. pmc Core temperature and sweat responses in professional women's tennis players during tournament play in the heat
    Melissa L Tippet
    Gatorade Sports Science Institute, Barrington, IL 60010, USA
    J Athl Train 46:55-60. 2011
    ..However, the actual effect of these breaks in reducing core temperature is unknown...
  61. ncbi The Arabidopsis trithorax-like factor ATX1 functions in dehydration stress responses via ABA-dependent and ABA-independent pathways
    Yong Ding
    University of Nebraska Center for Biotechnology and Center for Plant Science Innovation, 1901 Vine Street, Lincoln, NE 68588, USA
    Plant J 66:735-44. 2011
    ..Arabidopsis trithorax-like factor ATX1, which trimethylates histone H3 at lysine 4 (H3K4me3), is involved in dehydration stress signaling in both abscisic acid (ABA)-dependent and ABA-independent pathways...
  62. ncbi Evidence for airway surface dehydration as the initiating event in CF airway disease
    R C Boucher
    CF Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7248, USA
    J Intern Med 261:5-16. 2007
    ..Amongst the most productive hypotheses at present is the ''low airway surface liquid (ASL) volume'' or ''dehydration'' hypothesis...
  63. pmc Expression of heat shock protein-coding genes associated with anhydrobiosis in an African chironomid Polypedilum vanderplanki
    Oleg Gusev
    Anhydrobiosis Research Unit, National Institute of Agrobiological Sciences, 1 2 Ohwashi, Tsukuba, Ibaraki, 305 8634, Japan
    Cell Stress Chaperones 16:81-90. 2011
    ..All examined genes were significantly up-regulated in the larvae upon dehydration and several patterns of expression were detected...
  64. pmc Drought induction of Arabidopsis 9-cis-epoxycarotenoid dioxygenase occurs in vascular parenchyma cells
    Akira Endo
    Department of Biological Sciences, Tokyo Metropolitan University, Hachiouji, Tokyo 192 0397, Japan
    Plant Physiol 147:1984-93. 2008
    ..The spatial constraint of AtNCED3 expression in vascular tissues provides a novel insight into plant systemic response to drought stresses...
  65. ncbi Dehydration-responsive reversible and irreversible changes in the extracellular matrix: comparative proteomics of chickpea genotypes with contrasting tolerance
    Deepti Bhushan
    National Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi 110067, India
    J Proteome Res 10:2027-46. 2011
    b>Dehydration is the most crucial environmental factor that limits plant growth, development, and productivity affecting agriculture throughout the world...
  66. ncbi The induction of anhydrobiosis in the sleeping chironomid: current status of our knowledge
    Richard Cornette
    Anhydrobiosis Research Unit, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305 8634, Japan
    IUBMB Life 63:419-29. 2011
    ..allowing them to synthesize molecules, which will protect cells and tissues against the deleterious effects of dehydration. Trehalose, a nonreducing disaccharide, which accumulates in P...
  67. ncbi Assessing hydration status
    Stavros A Kavouras
    Laboratory of Nutrition and Clinical Dietetics, Department of Nutrition and Dietetics, Harokopio University, Athens, Greece
    Curr Opin Clin Nutr Metab Care 5:519-24. 2002
    ..Understanding the importance of euhydration in humans in order to ensure good health in various situations, the purpose of this review is to examine the available techniques in assessing hydration status...
  68. pmc Pregame urine specific gravity and fluid intake by National Basketball Association players during competition
    Kristin L Osterberg
    Gatorade Sports Science Institute, 617 West Main Street, Barrington, IL 60010, USA
    J Athl Train 44:53-7. 2009
    ..020). Whether initial hydration status based on a urine measure is related to subsequent drinking response during exercise or athletic competition is unclear...
  69. ncbi An ultratriathlon leads to a decrease of body fat and skeletal muscle mass--the Triple Iron Triathlon Austria 2006
    Beat Knechtle
    Gesundheitszentrum St Gallen, St Gallen, Switzerland
    Res Sports Med 16:97-110. 2008
    ..06). There is no association between total race time and the loss of BM (r(2) = 0.06), %BF (r(2) = 0.10), and SM (r2 = 0.11). No significant correlation (p > 0.05, r(2)= 0.43) was found between the initial SM and loss of SM...
  70. ncbi Saliva indices track hypohydration during 48h of fluid restriction or combined fluid and energy restriction
    Samuel J Oliver
    School of Sport, Health and Exercise Sciences, Bangor University, Bangor LL57 2PZ, UK
    Arch Oral Biol 53:975-80. 2008
    ..Following the 48h periods, UFR and Sosm were assessed after acute exercise dehydration and rehydration.
  71. ncbi Hydration and muscular performance: does fluid balance affect strength, power and high-intensity endurance?
    Daniel A Judelson
    Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, Connecticut, USA
    Sports Med 37:907-21. 2007
    ....
  72. ncbi Voluntary dehydration in runners despite favorable conditions for fluid intake
    Dennis Passe
    Gatorade Sports Science Institute, Barrington, IL 60010, USA
    Int J Sport Nutr Exerc Metab 17:284-95. 2007
    ..b>Dehydration averaged 1.9% +/- 0.8% of initial body weight (a mean sweat loss of 21.6 +/- 5.1 mL.kg-1.h-1)...
  73. ncbi Blood and urinary measures of hydration status during progressive acute dehydration
    L A Popowski
    Department of Exercise Science, University of Iowa, Iowa City, IA 52242, USA
    Med Sci Sports Exerc 33:747-53. 2001
    ..Posm, urine osmolarity (Uosm), and Usg were measured at 1%, 3%, and 5% dehydration, and 30 and 60 min of recovery (rec). Subjects consumed water in recovery equal to their loss of body weight...
  74. ncbi Dehydration in hospital-admitted stroke patients: detection, frequency, and association
    Anne Rowat
    Edinburgh Napier University, School of Nursing and Midwifery and Social Care, Edinburgh, Scotland
    Stroke 43:857-9. 2012
    We aimed to determine the frequency of dehydration, risk factors, and associations with outcomes at hospital discharge after stroke.
  75. ncbi Effects of acute dehydration on brain morphology in healthy humans
    Matthew J Kempton
    Centre for Neuroimaging Sciences, Institute of Psychiatry, King s College London, London, United Kingdom
    Hum Brain Mapp 30:291-8. 2009
    b>Dehydration can affect brain structure which has important implications for human health. In this study, we measured regional changes in brain structure following acute dehydration...
  76. ncbi Dehydration affects brain structure and function in healthy adolescents
    Matthew J Kempton
    Centre for Neuroimaging Sciences, Institute of Psychiatry, King s College London, London, SE5 8AF, United Kingdom
    Hum Brain Mapp 32:71-9. 2011
    It was recently observed that dehydration causes shrinkage of brain tissue and an associated increase in ventricular volume...
  77. pmc Decline of leaf hydraulic conductance with dehydration: relationship to leaf size and venation architecture
    Christine Scoffoni
    Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, California 90095 1606, USA
    Plant Physiol 156:832-43. 2011
    ..Because xylem embolism during dehydration also reduces K(leaf), we hypothesized that higher major vein density would also reduce hydraulic vulnerability...
  78. ncbi Hyponatremic dehydration as a presentation of cystic fibrosis
    Yolanda Ballestero
    Hospital Universitario 12 de Octubre, Madrid, Spain
    Pediatr Emerg Care 22:725-7. 2006
    The purpose of this study is to present a case report of a child with hyponatremic dehydration diagnosed after CF and to review the cases of 13 patients with CF who had the same initial presentation in our hospital.
  79. ncbi Adrenal splanchnic innervation modulates adrenal cortical responses to dehydration stress in rats
    Yvonne M Ulrich-Lai
    Department of Surgery, University of Minnesota, Minneapolis, 55455, USA
    Neuroendocrinology 76:79-92. 2002
    ..plasma corticosterone that were attenuated by splanchnic nerve transection, in the absence of changes in post-dehydration plasma ACTH...
  80. ncbi Overexpression of AtNHX5 improves tolerance to both salt and drought stress in Broussonetia papyrifera (L.) Vent
    Meiru Li
    Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, People s Republic of China
    Tree Physiol 31:349-57. 2011
    ....
  81. ncbi Identification of extracellular matrix proteins of rice (Oryza sativa L.) involved in dehydration-responsive network: a proteomic approach
    Aarti Pandey
    National Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi 110067, India
    J Proteome Res 9:3443-64. 2010
    Water-deficit or dehydration impairs almost all physiological processes and greatly influences the geographical distribution of many crop species...
  82. pmc Children with severe malnutrition: can those at highest risk of death be identified with the WHO protocol?
    Kathryn Maitland
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    PLoS Med 3:e500. 2006
    ....
  83. ncbi Constraints of tolerance: why are desiccation-tolerant organisms so small or rare?
    Peter Alpert
    Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
    J Exp Biol 209:1575-84. 2006
    ....
  84. pmc Genetic basis of drought resistance at reproductive stage in rice: separation of drought tolerance from drought avoidance
    Bing Yue
    National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research Wuhan, Huazhong Agricultural University, Wuhan, China
    Genetics 172:1213-28. 2006
    ..Only a small portion of QTL for fitness- and yield-related traits overlapped with QTL for root traits, indicating that DT and DA had distinct genetic bases...
  85. ncbi Activation of glucosidase via stress-induced polymerization rapidly increases active pools of abscisic acid
    Kwang Hee Lee
    Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang 790 784, Korea
    Cell 126:1109-20. 2006
    ..b>Dehydration rapidly induces polymerization of AtBG1, resulting in a 4-fold increase in enzymatic activity...
  86. pmc C4 photosynthesis and water stress
    Oula Ghannoum
    Centre for Plant and Food Science, University of Western Sydney, South Penrith DC, NSW, Australia
    Ann Bot 103:635-44. 2009
    ..Major gaps in our knowledge in this area are identified and further required research is suggested...
  87. ncbi Dehydration confounds the assessment of brain atrophy
    T Duning
    Department of Neurology, University of Munster, Albert Schweitzer Str 22, 48129 Munster, Germany
    Neurology 64:548-50. 2005
    ..The authors show that dehydration and rehydration can significantly change brain volume: lack of fluid intake for 16 hours decreased brain volume ..
  88. ncbi Influence of raised plasma osmolality on clinical outcome after acute stroke
    A Bhalla
    Department of Public Health Sciences, Guy s, King s and St Thomas Hospital School of Medicine, Guy s and St Thomas Hospital, London, England
    Stroke 31:2043-8. 2000
    ..Studies of the effect of dehydration on stroke outcome are limited...
  89. ncbi Accuracy of urine specific gravity and osmolality as indicators of hydration status
    Robert A Oppliger
    Iowa Wrestling Research, Iowa City, IA 52240, USA
    Int J Sport Nutr Exerc Metab 15:236-51. 2005
    To reduce the adverse consequences of exertion-related and acute intentional dehydration research has focused on monitoring hydration status...
  90. ncbi Dehydration markedly impairs cardiovascular function in hyperthermic endurance athletes during exercise
    J Gonzalez-Alonso
    Department of Kinesiology and Health Education, The University of Texas at Austin, 78712, USA
    J Appl Physiol (1985) 82:1229-36. 1997
    We identified the cardiovascular stress encountered by superimposing dehydration on hyperthermia during exercise in the heat and the mechanisms contributing to the dehydration-mediated stroke volume (SV) reduction...
  91. ncbi A study of the role of gene TaMYB2 and an associated SNP in dehydration tolerance in common wheat
    Bharti Garg
    International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, 110067, India
    Mol Biol Rep 39:10865-71. 2012
    ..the first time are reporting the identification of a synonymous single nucleotide polymorphism associated with dehydration tolerance at 458th bp (an A/G transition) in the TaMYB2 gene of wheat (Triticum aestivum L...
  92. ncbi The effects of dehydration on brain volume -- preliminary results
    J M Dickson
    Department of Biomedical Science, The University of Sheffield, Sheffield, UK
    Int J Sports Med 26:481-5. 2005
    ..This is the first study to investigate the relationship between dehydration and changes in the volume of the brain and the cerebral ventricles...
  93. pmc Enhanced abscisic acid-mediated responses in nia1nia2noa1-2 triple mutant impaired in NIA/NR- and AtNOA1-dependent nitric oxide biosynthesis in Arabidopsis
    Jorge Lozano-Juste
    Instituto de Biologia Molecular y Celular de Plantas, Consejo Superior de Investigaciones Cientificas Universidad Politecnica de Valencia, Ciudad Politécnica de Innovación, 46022 Valencia, Spain
    Plant Physiol 152:891-903. 2010
    ..seed dormancy, hypersensitivity to abscisic acid (ABA) in seed germination and establishment, as well as dehydration resistance...
  94. ncbi Saliva flow rate, total protein concentration and osmolality as potential markers of whole body hydration status during progressive acute dehydration in humans
    Neil P Walsh
    School of Sport, Health and Exercise Sciences, University of Wales, Bangor LL57 2PX, UK
    Arch Oral Biol 49:149-54. 2004
    ..saliva flow rate, total protein concentration and osmolality are sensitive non-invasive markers of whole body hydration status, we compared changes in these parameters with changes in body mass during progressive acute dehydration.
  95. ncbi Expression of OsDREB2A transcription factor confers enhanced dehydration and salt stress tolerance in rice (Oryza sativa L.)
    Garladinne Mallikarjuna
    Plant Molecular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India
    Biotechnol Lett 33:1689-97. 2011
    ..The ectopic overexpression of Dehydration-Responsive Element Binding transcription factors (DREBs) either in homologous or in heterologous plants ..
  96. ncbi The role of a gene cluster for trehalose metabolism in dehydration tolerance of the filamentous cyanobacterium Anabaena sp. PCC 7120
    Akiyoshi Higo
    Department of Molecular Biology, Faculty of Science, Saitama University, 255 Shimo ohkubo, Sakura ku, Saitama City, Saitama 338 8570, Japan
    Microbiology 152:979-87. 2006
    ..PCC 7120 was up-regulated markedly upon dehydration. However, the amount of trehalose accumulated during dehydration was small, whereas a large amount of sucrose ..
  97. ncbi Differential proteomic responses to water stress induced by PEG in two creeping bentgrass cultivars differing in stress tolerance
    Chenping Xu
    Department of Plant Biology and Pathology, Rutgers University, New Brunswick, NJ 08901, United States
    J Plant Physiol 167:1477-85. 2010
    ..Our results suggest that proteins involved in membrane synthesis, cell wall loosening, cell turgor maintenance, and antioxidant defense may play roles in perennial grass adaptation to PEG-induced water stress...
  98. ncbi Proteome analysis of leaves of the desiccation-tolerant grass, Sporobolus stapfianus, in response to dehydration
    Melvin J Oliver
    USDA ARS PGRU, Columbia, MO, USA
    Phytochemistry 72:1273-84. 2011
    ..Understanding how plants respond to dehydration is an important prerequisite for developing strategies for crop improvement in drought tolerance...
  99. ncbi Dehydration and vernalization treatments identify overlapping molecular networks impacting endodormancy maintenance in leafy spurge crown buds
    Münevver Doğramaci
    Biosciences Research Laboratory, USDA Agricultural Research Service, 1605 Albrecht Blvd N, Fargo, ND 58102 2765, USA
    Funct Integr Genomics 11:611-26. 2011
    ..In this study, the effects of dehydration stress on vegetative growth and flowering potential from endodormant UABs of leafy spurge was monitored...
  100. ncbi Rhododendron catawbiense plasma membrane intrinsic proteins are aquaporins, and their over-expression compromises constitutive freezing tolerance and cold acclimation ability of transgenic Arabidopsis plants
    Yanhui Peng
    Department of Horticulture, Iowa State University, Ames, IA, USA
    Plant Cell Environ 31:1275-89. 2008
    Extracellular freezing results in cellular dehydration caused by water efflux, which is likely regulated by aquaporins (AQPs)...
  101. ncbi Progressive dehydration causes a progressive decline in basketball skill performance
    Lindsay B Baker
    Noll Laboratory, Department of Kinesiology, Pennsylvania State University, University Park, PA 16802 6900, USA
    Med Sci Sports Exerc 39:1114-23. 2007
    To determine the effect of 1, 2, 3, and 4% dehydration (DEH) versus euhydration (EUH) on basketball performance in adult male players.

Research Grants68

  1. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  2. A Hybrid Katp Channel Opener to Prevent Radiocontrast-Induced Nephropathy
    Kanneganti Murthy; Fiscal Year: 2012
    ..Rats will be subjected to dehydration, prostaglandin synthetase inhibition, and an intravenous challenge of CM...
  3. A Thioredoxin Mimetic for Radiocontrast Nephropathy
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..of CIN, we now propose to construct a pharmacodynamic profile of R-901 in a rat model of CIN induced by dehydration, prostaglandin synthetase inhibition, and an IV challenge of CM...
  4. Mechanisms of Endothelin 1-Induced Sickle Cell Pathology
    Alicia Rivera; Fiscal Year: 2011
    ..Erythrocyte dehydration, a hallmark in SCD, is in part mediated by activation of the K/Cl cotransporter, Gardos channel, and Na+/Mg2+ ..
  5. Intracellular Phase Diagram Creation Using a Micro-Differential Scanning Calorime
    GARY L SOLBREKKEN; Fiscal Year: 2010
    ..The challenge with successful cryopreservation is developing cooling protocols that avoid cellular dehydration and intracellular ice formation...
  6. Molecular Regulation of Ischemic Renal Failure
    Zheng Dong; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: VA RELEVANCE: A broad range of clinical conditions including dehydration, hypotension, septic shock, trauma and operative arterial clamping leads to the reduction of blood flow to the ..
  7. Assessment of Dehydration in Children with Diarrhea in Resource-Limited Settings
    ADAM CARL LEVINE; Fiscal Year: 2013
    ..As the severity of the disease depends on the degree of fluid loss, accurately assessing dehydration status remains a crucial step in preventing morbidity and mortality...
  8. Radiocontrast Nephropathy: Redox Degradation Catalyst and Nitric Oxide Donor
    ZSUZSANNA KINGA ZSENGELLER; Fiscal Year: 2013
    ..diabetic rodents under conditions of normal hydration and aggressive volume loading Rats will be subjected to dehydration, prostaglandin synthetase inhibition, and an IV challenge of CM...
  9. Proteolytic Pathways in Thrombus Resolution
    Toni M Antalis; Fiscal Year: 2013
    ..Deployed military personnel are at increased risk due to prolonged air and ground transport, dehydration, tobacco use, and extended immobility during hospitalizations for severe injuries...
  10. Sodium Transport Inhibitors for Hypertension and Cystic Fibrosis
    John H Streiff; Fiscal Year: 2010
    ..drives hypertension;accelerated salt absorption across respiratory epithelial cells causes airway surface dehydration in CF...
  11. Sodium Transport Inhibitors for Hypertension and Cystic Fibrosis
    Erik Schwiebert; Fiscal Year: 2009
    ..drives hypertension;accelerated salt absorption across respiratory epithelial cells causes airway surface dehydration in CF...
  12. Discovery of Vibrio cholerae factors contributing to virulence in Drosophila.
    ALEXANDRA ELIZABETH PURDY; Fiscal Year: 2010
    ..This disease, characterized by massive water loss and dehydration due to diarrhea, can lead to death in less than 24 hours if rehydration therapy is not initiated immediately. V...
  13. Mechanism of CTIP2 action in mouse epidermal homeostasis and barrier formation,
    ARUP K INDRA; Fiscal Year: 2012
    ..problem in the majority of premature infants, results in increased transepidermal water loss with concomitant dehydration and electrolyte imbalance, as well as fragile skin...
  14. Structural Biology of Enterotoxin Secretion from Bacterial Cells
    WILHELMUS G J HOL; Fiscal Year: 2013
    ..enterotoxigenic Escherichia coli (ETEC) is in the third world a major cause of infant diarrhea and death due to dehydration. Key virulence factors of V...
  15. LISTERIA AND SHIGELLA USE ACTIN TO SPREAD CELL TO CELL
    Frederick Southwick; Fiscal Year: 2013
    ..causes bacteremia and meningitis, while the gram negative bacillus Shigella flexneri causes severe diarrhea and dehydration. The pathogenesis of Listeriosis and Shigellosis absolutely requires these intracellular bacteria to usurp the ..
  16. Antimicrobial and Regenerative Treatment for Oral Mucositis
    SHENDA BAKER; Fiscal Year: 2012
    ..Mucositis is associated with significant morbidity including pain, oral lesions, dehydration and nutritional compromise including limiting calorie intake and malnutrition as well as the high risk for ..
  17. The Endothelial Glycocalyx: Its Structure and Function and as a Mechanotransducer
    John M Tarbell; Fiscal Year: 2013
    ..Because of dehydration artifacts associated with conventional electron microscopy, even such rudimentary characteristics as the ..
  18. Development of swallow evoked potentials as a novel tool to investigate swallowin
    Teresa E Lever; Fiscal Year: 2012
    ..Common symptoms include malnutrition, dehydration, and respiratory complications, all of which may result in a poor quality of life and contribute to death in ..
  19. Regulation and function of innate lymphoid cells in the gut
    David Artis; Fiscal Year: 2013
    ..four to six million deaths per year worldwide are caused by bacterial-induced diarrhea and the associated dehydration represents the second most common cause of infant mortality around the world...
  20. Crystallization Robot for the Structural Biology Resource Center at Rockefeller
    DEENA ABELLS OREN; Fiscal Year: 2010
    ..precipitant solution and the protein) is significantly less than other crystallization robots, thereby reducing dehydration time by at least half...
  21. Selection of an anti-ceramide mitigator of acute radiation toxicity of the GI tra
    Jimmy Rotolo; Fiscal Year: 2012
    ..tract, resulting in denudation of the GI epithelium, and death due to lack of nutrient adsorption, diarrhea and dehydration, electrolyte imbalance and enterobacterial sepsis...
  22. Mitochondrial ROS Regulate Skin and Hair Homeostasis
    Navdeep S Chandel; Fiscal Year: 2012
    ..The epidermis also protects us from excessive fluid loss, preventing dehydration. In order to maintain its protective function, epidermis and its appendages the hair follicles (HF) and ..
  23. Using genomics to understand physiologic water conservation in desert rodents
    MATTHEW MACMANES; Fiscal Year: 2013
    ..When the loss of water exceeds dietary intake, dehydration occurs...
  24. The Impact of Tobacco Exposure on the Lungs Innate Defense System
    Robert Tarran; Fiscal Year: 2013
    ..More specifically, tobacco smoke causes ain/vay surface liquid/mucus dehydration and increased incidence of viral infections, suggesting that the Lung's Innate Defense System has been ..
  25. Using Molecular Modeling to Determine Structure and Organization in Skin Lipids
    Clare McCabe; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The Skin's function as a barrier to infection, dehydration and chemical assault is critical to health and survival...
  26. Translational Control by Osmotically Active Solutes
    Maria Hatzoglou; Fiscal Year: 2013
    ..hyperglycemia in diabetes (HHS, Hyperglycemic Hyperosmolar State), macrophage cell death in inflammatory sites, dehydration of the ocular surface in dry eye syndrome and increased susceptibility to infections and retinal cell apoptosis ..
  27. Single Molecule Studies of Class II Lantibiotic Synthetases
    CHRISTOPHER JAMES THIBODEAUX; Fiscal Year: 2012
    ..The post-translational modifications (PTMs) that are common to all lantipeptides include the ATP-dependent dehydration of serine and threonine residues in the peptide substrate (LanA) to form dehydroalanine (Dha) and ..
  28. Manual Control of the Upper Esophageal Sphincter
    Peter Belafsky; Fiscal Year: 2013
    ..Untreated dysphagia can lead to dehydration, malnutrition, aspiration pneumonia, and death...
  29. Portable device for monitoring water balance in elderly
    Armen Sarvazyan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dehydration is a frequent cause of morbidity and mortality in the elderly...
  30. Mechanisms of Oxidative Stress and Inflammation during Prolonged Fasting and Slee
    Rudy M Ortiz; Fiscal Year: 2013
    ..protracted periods of absolute food and water deprivation for up to 3 months without exhibiting any indices of dehydration or electrolyte imbalances...
  31. SCCOR in Host Factors in Chronic Lung Disease
    Richard C Boucher; Fiscal Year: 2010
    ..of the normal and cigarette smoke-exposed lung to mimics of aspects of COPD/CF disease;Project V: Mucus Dehydration and Evolution of COPD Lung Disease (R...
  32. In-Patient Pediatric Gastrojejunal Tube Cleaner Eliminating Surgical Intervention
    Ryan S Clement; Fiscal Year: 2013
    ..young pediatric patients tend to exhaust energy reserves very quickly and are highly susceptible to the dehydration, and hypo- and hyper-glycemia that can result from a clogged tube. In the U.S...
  33. Portable device for monitoring water balance in elderly
    Armen Sarvazyan; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Dehydration is a frequent cause of morbidity and mortality in the elderly...
  34. Tongue-pressure timing for liquid flow detection and control in swallowing
    CATRIONA MARGARET STEELE; Fiscal Year: 2012
    ..Dysphagia puts individuals at risk for malnutrition, dehydration and pneumonia and adversely affects quality of life...
  35. Ginger Extract: Bioavailability Study and Lung Cancer Preventive Effect
    Shengmin Sang; Fiscal Year: 2010
    ..Ginger also contains shogaol homologues that are formed by dehydration of corresponding gingerols during storage or thermal processing...
  36. Enhanced Recovery of Pharmaceutical Solvent driven by EPA Initiative
    JOHN J BOWSER; Fiscal Year: 2013
    ..To enhance the potential for "universal" PS dehydration, CMS will develop A) membranes with enhanced water/solvent separation and B) more resistant system which ..
  37. Thirst Deficits in Rat Model of Aging
    Robert L Thunhorst; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Impaired sensations of thirst are the major cause of dehydration and disturbances of fluid balance that pose major health problems for the elderly...
  38. Epithelial Stem Cell Migration during Wound Repair
    CATHERINE PEI JU LU; Fiscal Year: 2013
    ..injury, the skin epidermis must undergo immediate repair mechanism to restore its barrier function to prevent dehydration and invasion of harmful pathogens...
  39. NEURAL MECHANISMS OF ANOREXIA
    Alan G Watts; Fiscal Year: 2012
    ..To generate anorexia experimentally, the project will use the chronic dehydration that follows drinking hypertonic saline...
  40. Purines as Biomarkers of Respiratory Disease
    CHARLES RICHARD ESTHER; Fiscal Year: 2013
    ..such as cystic fibrosis (CF) are characterized by a cascade of pathophysiological changes starting with dehydration of mucus secretions and proceeding to impaired mucociliary clearance, chronic airway inflammation, and ..
  41. Multicolor Cell Membrane Profiling For Development And Disease
    BRIAN DAVID GRAY; Fiscal Year: 2013
    ..is their limited combination with other procedures such as immunostaining or detailed histology that requires dehydration for embedding, since the dye molecules are not permanently bound to the membranes and can either leak out or be ..
  42. Investigation into the antibiotic activity of the lantibiotic haloduracin
    Rebecca A Splain; Fiscal Year: 2013
    ..Enzymatic dehydration of serine and threonine residues present in the precursor peptide yield dehydroalanine and dehydrobutyrine ..
  43. Cognitive function, hyperthermia, and aging
    ZACHARY JOSEPH SCHLADER; Fiscal Year: 2013
    ..Specifically, we will test the hypothesis that dehydration impairs cognitive function with hyperthermia, but to a greater extent with healthy aging...
  44. Development of a Cell-Derived Human Skin Substitute for Acute and Chronic Wounds
    ALLEN R COMER; Fiscal Year: 2012
    ..25 million Americans each year. Extensive damage to the skin has serious repercussions, leading to dehydration, increased metabolic load, entry of toxic substances, immunosuppression, and wound infection...
  45. Membrane Mechanics, Osmotic Stress, and the Yeast Stretch-Activated TRP
    Yoshiro Saimi; Fiscal Year: 2010
    ..The yeast TRP channel, Yvc1p, instantly opens when cells are confronted with hyperosmolarity (= dehydration) to release Ca2+ from vacuole to cytoplasm...
  46. Biosynthesis of Microbial Polyketides
    David E Cane; Fiscal Year: 2013
    ..polyketide intermediates;3) understanding the mechanism, substrate specificity, and stereochemistry of the dehydration reactions catalyzed by dehydratase (DH) domains, both alone and in intact modules;and 4) elucidating the ..
  47. Th2 inflammation promotes airway surface liquid dehydration
    MICHAEL M MYERBURG; Fiscal Year: 2013
    ..Thus, airway surface dehydration presents a novel mechanistic explanation for the development of mucus dysfunction in subgroups of asthma ..
  48. Cost-Effectiveness of Two Nutrition Interventions in Long-Term Care
    Sandra F Simmons; Fiscal Year: 2013
    ..fluid intake is a common problem among nursing home (NH) residents and one that can lead to under-nutrition, dehydration, weight loss, hospitalization, and even death...
  49. The Pathogenesis of Sickle Cell Nephropathy
    Antonio Guasch; Fiscal Year: 2010
    ..and the kidney medulla which causes an inability to concentrate the urine, making the patients prone to dehydration. In the same animal model, we will study whether the renal damage described in our preliminary data and further ..
  50. Mucus and hypoxia in heterogeneous and progressive CF lung disease
    Stephen Stick; Fiscal Year: 2013
    ..the "vulnerability defect" reflects localized loss of mucus clearance mechanisms due to airway surface dehydration, and 3) immobilized, relatively dehydrated mucus masses obstruct airways, stimulate inflammation, and serve as ..
  51. Breastfeeding the Late Preterm Infant: A Grounded Theory Study
    Jill Radtke Demirci; Fiscal Year: 2012
    ..that late preterm infants who are breastfed tend to present with diagnoses of failure to thrive, jaundice, and dehydration at much higher rates than those who are not breastfed, a finding largely attributed to insufficient breast milk ..
  52. Frontiers in Ichthyosis Research
    William B Rizzo; Fiscal Year: 2010
    ..Some have medical complications, such as dehydration, recurrent infections, chronic blistering, and overheating...
  53. Investigation of Effective Training of "promotoras" in Oral Rehydration Therapy
    RACHEL ANN HALL-CLIFFORD; Fiscal Year: 2013
    ..of knowledge through the use of local promotora programs, thereby preventing childhood deaths due to dehydration associated with diarrheal diseases...
  54. Hypertonic Saline for Cystic Fibrosis
    Benjamin Yerxa; Fiscal Year: 2011
    ..CF lung disease, the major cause of mortality in CF, is caused by dehydration of airway secretions that leads to mucous adhesion, infection and airways inflammation...
  55. CFTR Delivery to Ciliated Airway Cells by PIV Vectors
    Raymond Pickles; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Cystic fibrosis (CF) lung disease causes dehydration of the surface lining of the respiratory epithelium leading to mucostasis and chronic bacterial infection...
  56. Mucus Adhesion to Epithelial Cells and its Mobilization in COPD and CF
    Michael Rubinstein; Fiscal Year: 2012
    ..We hypothesize that a unifying feature of CB diseases is dehydration of mucus that reflects common elements of pathogenesis in both genetic (e.g...
  57. Sensor-assisted prevention of dehydration in head and neck cancer patients
    Eileen H Shinn; Fiscal Year: 2013
    ..Those admissions related to dehydration (and the accompanying costs) are largely preventable, provided at-risk patients can be identified early for ..
  58. Role of Chromatin Regulators in Skin Control
    Elena Ezhkova; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Skin is an essential barrier that protects the body from infection and dehydration. It is also an important sensory organ that allows animals to perceive touch, pain, and temperature...
  59. Microencapsulation of oocytes for low-CPA (cryoprotectant) vitrification
    Xiaoming He; Fiscal Year: 2013
    ..approach is associated with inevitable cell injury due to ice formation and slow- freezing induced cell dehydration. The unusually high CPA (cryoprotectant) concentration (4 - 7 M) required by the conventional vitrification (..
  60. Seasonal Impact of iron fortification on malaria incidence in Ghanaian children
    Stanley H Zlotkin; Fiscal Year: 2010
    ..as differences in secondary complications of malaria infections, such as death, cerebral malaria, pneumonia, dehydration, and diarrhea...
  61. Hypertonic Saline for Cystic Fibrosis
    BILL THELIN; Fiscal Year: 2013
    ..CF lung disease, the major cause of mortality in CF, is caused by dehydration of airway secretions that leads to mucous adhesion, infection and airways inflammation...
  62. CRYOPRESERVATION OF DROSOPHILA MELANOGASTER EMBRYOS
    PETER STEPONKUS; Fiscal Year: 1993
    ..vitrification procedure on the frequency of pupariation will be conducted, with optimization of the loading and dehydration steps...
  63. PHYSIOLOGICAL MECHANISMS OF VERTEBRATE FREEZE TOLERANCE
    RICHARD LEE JR; Fiscal Year: 1991
    ..The water for this ice comes from the extensive dehydration of organs; some lose nearly 60% of their initial water...
  64. Long Term Outcomes in ICU Patients: Delirium & Apolipoprotein E
    Sheila Alexander; Fiscal Year: 2009
    ..increasing age, metabolic disturbances, electrolyte imbalances, drug (alcohol withdrawal, infection, seizures, dehydration, hyperthermia, head trauma, vascular disorders, intracranial space occupying lesions and others...
  65. MATERNAL DEHYDRATION--FETAL/AMNIOTIC FLUID HOMEOSTASIS
    Michael Ross; Fiscal Year: 2002
    ..The goal of this project is to determine critical efficacy and fetal safety issues central to maternal DDAVP treatment, prior to widespread clinical use in human pregnancies with oligohydramnios. ..
  66. CRYPTOSPORIDIUM DHFR AS A CHEMOTHERAPEUTIC TARGET
    Richard Nelson; Fiscal Year: 1992
    ..Symptoms may include profuse watery diarrhea with dehydration and malnutrition; extraintestinal complications include involvement of the biliary tract, pancreas, and lungs...
  67. MOLECULAR DISSECTION OF CONGENITAL NEPHROGENIC DI
    ROBERT WILDIN; Fiscal Year: 2000
    ..In infants, the hyperosmolar dehydration may result in permanent brain damage or death...
  68. AMINO ACID TRANSPORT AFTER SMALL BOWEL RESECTION
    HARRY SAX; Fiscal Year: 2004
    Short bowel syndrome is a devastating clinical condition which leads to dehydration, muscle wasting, debilitation and death...