sudden infant death

Summary

Summary: The abrupt and unexplained death of an apparently healthy infant under one year of age, remaining unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of the clinical history. (Pediatr Pathol 1991 Sep-Oct;11(5):677-84)

Top Publications

  1. ncbi Cytokine responses and sudden infant death syndrome: genetic, developmental, and environmental risk factors
    C Caroline Blackwell
    Faculty of Health, School of Biomedical Sciences, University of Newcastle and Hunter Medical Research Institute, John Hunter Hospital, Lookout Road, New Lambton, NSW 2300, Australia
    J Leukoc Biol 78:1242-54. 2005
  2. ncbi Prevalence of long-QT syndrome gene variants in sudden infant death syndrome
    Marianne Arnestad
    Institute of Forensic Medicine, University of Oslo, Oslo, Norway
    Circulation 115:361-7. 2007
  3. pmc Sudden infant death syndrome in mice with an inherited mutation in RyR2
    Nitin Mathur
    Department of Molecular Physiology and Biophysics, Division of Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
    Circ Arrhythm Electrophysiol 2:677-85. 2009
  4. ncbi Possible pathomechanisms of sudden infant death syndrome: key role of chronic hypoxia, infection/inflammation states, cytokine irregularities, and metabolic trauma in genetically predisposed infants
    Joseph Prandota
    Faculty of Medicine and Dentistry, and Department of Social Pediatrics, Faculty of Public Health, University Medical School, Wroclaw, Poland
    Am J Ther 11:517-46. 2004
  5. ncbi Maternal smoking and alcohol consumption during pregnancy as risk factors for sudden infant death
    M McDonnell-Naughton
    Department of Nursing and Health Science, Athlone Institute of Technology, Co Westmeath
    Ir Med J 105:105-8. 2012
  6. doi Breastfeeding and reduced risk of sudden infant death syndrome: a meta-analysis
    Fern R Hauck
    Department of Family Medicine, University of Virginia School of Medicine, PO Box 800729, Charlottesville, VA 22908, USA
    Pediatrics 128:103-10. 2011
  7. pmc A mechanism for sudden infant death syndrome (SIDS): stress-induced leak via ryanodine receptors
    David J Tester
    Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota 55901, USA
    Heart Rhythm 4:733-9. 2007
  8. pmc Risk factor changes for sudden infant death syndrome after initiation of Back-to-Sleep campaign
    Felicia L Trachtenberg
    New England Research Institutes, Watertown, Massachusetts, USA
    Pediatrics 129:630-8. 2012
  9. ncbi Electrospray tandem mass spectrometry for analysis of acylcarnitines in dried postmortem blood specimens collected at autopsy from infants with unexplained cause of death
    D H Chace
    Neo Gen Screening, PO Box 219, Bridgeville, PA 15017, USA
    Clin Chem 47:1166-82. 2001
  10. ncbi Recent national trends in sudden, unexpected infant deaths: more evidence supporting a change in classification or reporting
    Carrie K Shapiro-Mendoza
    Maternal and Infant Health Branch, Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA 30341 3717, USA
    Am J Epidemiol 163:762-9. 2006

Detail Information

Publications279 found, 100 shown here

  1. ncbi Cytokine responses and sudden infant death syndrome: genetic, developmental, and environmental risk factors
    C Caroline Blackwell
    Faculty of Health, School of Biomedical Sciences, University of Newcastle and Hunter Medical Research Institute, John Hunter Hospital, Lookout Road, New Lambton, NSW 2300, Australia
    J Leukoc Biol 78:1242-54. 2005
    Despite the success of the campaigns to reduce the risk of sudden infant death syndrome (SIDS), it still remains the major cause of postneonatal mortality...
  2. ncbi Prevalence of long-QT syndrome gene variants in sudden infant death syndrome
    Marianne Arnestad
    Institute of Forensic Medicine, University of Oslo, Oslo, Norway
    Circulation 115:361-7. 2007
    The hypothesis that some cases of sudden infant death syndrome (SIDS) could be caused by long-QT syndrome (LQTS) has been supported by molecular studies...
  3. pmc Sudden infant death syndrome in mice with an inherited mutation in RyR2
    Nitin Mathur
    Department of Molecular Physiology and Biophysics, Division of Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
    Circ Arrhythm Electrophysiol 2:677-85. 2009
    Mutations in the cardiac ryanodine receptor gene (RyR2) have been recently identified in victims of sudden infant death syndrome...
  4. ncbi Possible pathomechanisms of sudden infant death syndrome: key role of chronic hypoxia, infection/inflammation states, cytokine irregularities, and metabolic trauma in genetically predisposed infants
    Joseph Prandota
    Faculty of Medicine and Dentistry, and Department of Social Pediatrics, Faculty of Public Health, University Medical School, Wroclaw, Poland
    Am J Ther 11:517-46. 2004
    ..inflammation states, biochemical disorders, and genetic abnormalities are the most likely trigger of sudden infant death syndrome (SIDS)...
  5. ncbi Maternal smoking and alcohol consumption during pregnancy as risk factors for sudden infant death
    M McDonnell-Naughton
    Department of Nursing and Health Science, Athlone Institute of Technology, Co Westmeath
    Ir Med J 105:105-8. 2012
    ..The adjusted odds ratio for those consuming alcohol in all three trimesters was 3.59 (CI:1.40-9.20). Both of these risk factors are modifiable and need to be incorporated into antenatal education from a SIDS point of view...
  6. doi Breastfeeding and reduced risk of sudden infant death syndrome: a meta-analysis
    Fern R Hauck
    Department of Family Medicine, University of Virginia School of Medicine, PO Box 800729, Charlottesville, VA 22908, USA
    Pediatrics 128:103-10. 2011
    Benefits of breastfeeding include lower risk of postneonatal mortality. However, it is unclear whether breastfeeding specifically lowers sudden infant death syndrome (SIDS) risk, because study results have been conflicting.
  7. pmc A mechanism for sudden infant death syndrome (SIDS): stress-induced leak via ryanodine receptors
    David J Tester
    Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota 55901, USA
    Heart Rhythm 4:733-9. 2007
    b>Sudden infant death syndrome (SIDS) is the leading cause of postneonatal mortality in the United States...
  8. pmc Risk factor changes for sudden infant death syndrome after initiation of Back-to-Sleep campaign
    Felicia L Trachtenberg
    New England Research Institutes, Watertown, Massachusetts, USA
    Pediatrics 129:630-8. 2012
    To test the hypothesis that the profile of sudden infant death syndrome (SIDS) changed after the Back-to-Sleep (BTS) campaign initiation, document prevalence and patterns of multiple risks, and determine the age profile of risk factors.
  9. ncbi Electrospray tandem mass spectrometry for analysis of acylcarnitines in dried postmortem blood specimens collected at autopsy from infants with unexplained cause of death
    D H Chace
    Neo Gen Screening, PO Box 219, Bridgeville, PA 15017, USA
    Clin Chem 47:1166-82. 2001
    ..inherited metabolic disorders may remain undiagnosed after postmortem examination and may be classified as sudden infant death syndrome...
  10. ncbi Recent national trends in sudden, unexpected infant deaths: more evidence supporting a change in classification or reporting
    Carrie K Shapiro-Mendoza
    Maternal and Infant Health Branch, Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA 30341 3717, USA
    Am J Epidemiol 163:762-9. 2006
    The recent US decline in sudden infant death syndrome (SIDS) rates may be explained by a shift in how these deaths are classified or reported...
  11. ncbi Differences in mortality between late-preterm and term singleton infants in the United States, 1995-2002
    Kay M Tomashek
    Maternal and Infant Health Branch, Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Pediatr 151:450-6, 456.e1. 2007
    ..To assess differences in mortality between late-preterm (34-36 weeks) and term (37-41 weeks) infants...
  12. pmc Loss-of-function mutations in the KCNJ8-encoded Kir6.1 K(ATP) channel and sudden infant death syndrome
    David J Tester
    Department of Medicine, Division of Cardiovascular Diseases, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN 55905, USA
    Circ Cardiovasc Genet 4:510-5. 2011
    Approximately 10% of sudden infant death syndrome (SIDS) may stem from cardiac channelopathies. The KCNJ8-encoded Kir6...
  13. doi Diurnal temperature range as a novel risk factor for sudden infant death
    Chen Chu
    Cardiovascular Center, Children s Hospital of Fudan University, Shanghai 201102, China
    Biomed Environ Sci 24:518-22. 2011
    To assess the relationship between diurnal temperature range (DTR) and sudden infant death (SID) between 2001 and 2004 in Shanghai, China.
  14. pmc Lack of association of the serotonin transporter polymorphism with the sudden infant death syndrome in the San Diego Dataset
    David S Paterson
    Department of Pathology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Res 68:409-13. 2010
    ..respiratory and autonomic function is postulated to underlie the pathogenesis of the majority of sudden infant death syndrome (SIDS) cases...
  15. ncbi Bed-sharing in the first four months of life: a risk factor for sudden infant death
    Jan H Ruys
    Leiden University Medical Center, Reviuslaan 38, 2343 JR Oegstgeest, The Netherlands
    Acta Paediatr 96:1399-403. 2007
    To investigate the risk of sudden infant death in the Netherlands during bed-sharing in the first half year of life and the protective effect of breastfeeding on it.
  16. pmc Connexin43 mutation causes heterogeneous gap junction loss and sudden infant death
    David W Van Norstrand
    Mayo Clinic, MN 55905, USA
    Circulation 125:474-81. 2012
    An estimated 10% to 15% of sudden infant death syndrome (SIDS) cases may stem from channelopathy-mediated lethal arrhythmias...
  17. ncbi Serotonin transporter gene variation is a risk factor for sudden infant death syndrome in the Japanese population
    N Narita
    Department of Pediatrics, Dokkyo University, School of Medicine, Koshigaya Hospital, Saitama, Japan
    Pediatrics 107:690-2. 2001
    ..Therefore, we aimed to identify the possibility that specific allele variants of the 5-HTT gene can be found as a genetic background for sudden infant death syndrome (SIDS).
  18. pmc An 8 year study of risk factors for SIDS: bed-sharing versus non-bed-sharing
    C McGarvey
    National Sudden Infant Death Register, George s Hall, The Children s University Hospital, Temple St, Dublin 1, Ireland
    Arch Dis Child 91:318-23. 2006
    It is unclear if it is safe for babies to bed share with adults. In Ireland 49% of sudden infant death syndrome (SIDS) cases occur when the infant is bed-sharing with an adult.
  19. pmc Hazardous cosleeping environments and risk factors amenable to change: case-control study of SIDS in south west England
    Peter S Blair
    Department of Community Based Medicine, University of Bristol
    BMJ 339:b3666. 2009
    To investigate the factors associated with sudden infant death syndrome (SIDS) from birth to age 2 years, whether recent advice has been followed, whether any new risk factors have emerged, and the specific circumstances in which SIDS ..
  20. ncbi Factors associated with the transition to nonprone sleep positions of infants in the United States: the National Infant Sleep Position Study
    M Willinger
    Pregnancy and Perinatology Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 7510, USA
    JAMA 280:329-35. 1998
    Studies have demonstrated strong associations between the prone sleep position (on the stomach) and sudden infant death syndrome (SIDS)...
  21. ncbi The G protein beta3 subunit 825C allele is associated with sudden infant death due to infection
    Siri Hauge Opdal
    Institute of Forensic Medicine, University of Oslo, Department of Medical Biochemistry, Rikshospitalet University Hospital, Oslo, Norway
    Acta Paediatr 95:1129-32. 2006
    ..The reported association between the Gbeta3s protein and increased immune cell function in humans makes this polymorphism highly interesting both with regard to sudden infant death syndrome (SIDS) and deleterious infectious disease.
  22. pmc A perspective on SIDS pathogenesis. the hypotheses: plausibility and evidence
    Paul N Goldwater
    Microbiology and Infectious Diseases, SA Pathology at the Women s and Children s Hospital
    BMC Med 9:64. 2011
    Several theories of the underlying mechanisms of Sudden Infant Death Syndrome (SIDS) have been proposed...
  23. doi Intrathoracic petechial hemorrhages in sudden infant death syndrome and other infant deaths: time for re-examination
    Paul N Goldwater
    Microbiology and Infectious Diseases Department, The Women s and Children s Hospital, Discipline of Paediatrics, Children, Youth and Women s Health Service, North Adelaide, South Australia 5006, Australia
    Pediatr Dev Pathol 11:450-5. 2008
    ..pathogenesis of intrathoracic petechial hemorrhages through a retrospective autopsy report review of 174 sudden infant death syndrome (SIDS) cases (2004 definition) and 67 age-matched comparison deaths...
  24. doi The frequency of molecular detection of virulence genes encoding cytolysin A, high-pathogenicity island and cytolethal distending toxin of Escherichia coli in cases of sudden infant death syndrome does not differ from that in other infant deaths and healt
    Amanda R Highet
    Department of Microbiology and Infectious Diseases, Women s and Children s Hospital, North Adelaide, South Australia, Australia
    J Med Microbiol 58:285-9. 2009
    Consistent pathological findings in sudden infant death syndrome (SIDS) are seen which display similarities to the pathogenesis of toxaemic shock and/or sepsis...
  25. ncbi Review of risk factors for sudden infant death syndrome
    F M Sullivan
    Division of Pharmacology and Toxicology, United Medical School, University of London, UK
    Paediatr Perinat Epidemiol 15:144-200. 2001
    b>Sudden infant death syndrome (SIDS) accounts for the largest number of deaths during the first year of life in developed countries...
  26. ncbi Clinical correlates, natural history and outcome of neonatal apnoea
    Terry M Baird
    Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH 44106, USA
    Semin Neonatol 9:205-11. 2004
    ..Infants who have apnoea in the newborn period are thought not to be at higher risk for sudden infant death syndrome (SIDS)...
  27. ncbi SIDS: past, present and future
    Edwin A Mitchell
    Department of Paediatrics, University of Auckland, Auckland, New Zealand
    Acta Paediatr 98:1712-9. 2009
    ..This paper describes the position in the 1980s, the contribution of the New Zealand Cot Death Study, what should be recommended and the current research priorities...
  28. ncbi Sudden infant death syndrome: how significant are the cardiac channelopathies?
    David J Tester
    Department of Medicine, Mayo Clinic College of Medicine, United States
    Cardiovasc Res 67:388-96. 2005
    ..This tragedy is compounded when the infant's death is unexpected and unexplained, signed out as sudden infant death syndrome (SIDS)...
  29. pmc Prenatal nicotine-exposure alters fetal autonomic activity and medullary neurotransmitter receptors: implications for sudden infant death syndrome
    Jhodie R Duncan
    Dept of Pathology, Enders 1112 1, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    J Appl Physiol (1985) 107:1579-90. 2009
    During pregnancy, exposure to nicotine and other compounds in cigarette smoke increases the risk of the sudden infant death syndrome (SIDS) two- to fivefold...
  30. pmc Social deprivation and the causes of stillbirth and infant mortality
    Z E Guildea
    Department of Child Health, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Arch Dis Child 84:307-10. 2001
    ..The early neonatal mortality rate was not significantly associated with deprivation. Sudden infant death syndrome showed a 307% (95% CI 197% to 456%) increase in mortality across the range of deprivation...
  31. ncbi An infectious aetiology of sudden infant death syndrome
    A R Highet
    Department of Microbiology and Infectious Diseases, Children, Youth and Women s Health Service, Women s and Children s Hospital, North Adelaide, SA, Australia
    J Appl Microbiol 105:625-35. 2008
    Due attention has been given to infectious agents and immune responses to infection in sudden infant death syndrome (SIDS)...
  32. ncbi Smoking and the sudden infant death syndrome
    E A Mitchell
    Department of Paediatrics, University of Auckland, New Zealand
    Rev Environ Health 21:81-103. 2006
    ..are (a) to critically examine the epidemiologic evidence for a possible association between smoking and the sudden infant death syndrome (SIDS), (b) to review the pathology and postulated physiological mechanism(s) by which smoking ..
  33. doi International trends in sudden infant death syndrome: stabilization of rates requires further action
    Fern R Hauck
    University of Virginia School of Medicine, Department of Family Medicine, PO Box 800729, Charlottesville, VA 22908 0729, USA
    Pediatrics 122:660-6. 2008
  34. ncbi Cardiorespiratory events recorded on home monitors: Comparison of healthy infants with those at increased risk for SIDS
    R Ramanathan
    Department of Pediatrics, Yale Medical School, Box 208064, New Haven, CT 06520-8064, USA
    JAMA 285:2199-207. 2001
    ..monitors designed to identify cardiorespiratory events are frequently used in infants at increased risk for sudden infant death syndrome (SIDS), but the efficacy of such devices for this use is unproven...
  35. ncbi The triple risk hypotheses in sudden infant death syndrome
    Warren G Guntheroth
    Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington 98195 6320, USA
    Pediatrics 110:e64. 2002
    b>Sudden infant death syndrome (SIDS) victims were regarded as normal as a matter of definition (Beckwith 1970) until 1952 when Kinney and colleagues argued for elimination of the clause, "unexpected by history...
  36. doi Studying sudden and unexpected infant deaths in a time of changing death certification and investigation practices: evaluating sleep-related risk factors for infant death in New York City
    Lindsay Senter
    Bureau of Maternal, Infant and Reproductive Health, New York City Department of Health and Mental Hygiene, 2 Lafayette Street, New York, NY 10007, USA
    Matern Child Health J 15:242-8. 2011
    ..This will help jurisdictions interpret their infant mortality statistics, which in turn will improve education and prevention efforts...
  37. doi Influence of environmental factors in higher risk of sudden infant death syndrome linked with parental mental illness
    Roger T Webb
    Centre for Women s Mental Health and Health Methodology Research Group, University of Manchester, Room 2 311, University Place, Oxford Road, Manchester M13 9PL, England
    Arch Gen Psychiatry 67:69-77. 2010
    Since national risk reduction campaigns have been conducted, sudden infant death syndrome (SIDS) has become increasingly concentrated among disadvantaged families, including those affected by mental illness...
  38. ncbi Infant-parent co-sleeping in an evolutionary perspective: implications for understanding infant sleep development and the sudden infant death syndrome
    J J McKenna
    Pomona College, Claremont, California 91711
    Sleep 16:263-82. 1993
    ..of optimal sleep patterning in infants and confer other benefits, including reducing the risk of the sudden infant death syndrome (SIDS). These postulations by McKenna are considered from different perspectives by the coauthors...
  39. ncbi Sarcomeric gene mutations in sudden infant death syndrome (SIDS)
    Maria Brion
    Genetics of Cardiovascular and Ophthalmologic Diseases, Hospital University Complex of Santiago CHUS, Santiago de Compostela, Spain
    Forensic Sci Int 219:278-81. 2012
    In developed countries, sudden infant death syndrome (SIDS) represents the most prevalent cause of death in children between 1 month and 1 year of age...
  40. ncbi An audit of the use of definitions of sudden infant death syndrome (SIDS)
    Roger W Byard
    Discipline of Pathology, Level 3, Medical School North, The University of Adelaide, Frome Road, Adelaide 5005, Australia
    J Forensic Leg Med 14:453-5. 2007
    ..Failure to use standard published definitions of SIDS and/or to clearly specify the definition that has been followed may severely hamper the evaluation of SIDS research...
  41. ncbi The metabolic investigation of sudden infant death
    Simon E Olpin
    Department of Clinical Chemistry, Sheffield Children s Hospital, Sheffield S10 2TH, UK
    Ann Clin Biochem 41:282-93. 2004
    ..In particular, inherited disorders of fatty acid oxidation may closely mimic sudden infant death syndrome. Post-mortem investigations offer the final opportunity to establish a diagnosis...
  42. ncbi A serotonin malfunction hypothesis by finding clear mutual relationships between several risk factors and symptoms associated with sudden infant death syndrome
    N Okado
    Neurobiology Laboratory, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8577, Japan
    Med Hypotheses 58:232-6. 2002
    ..variants in the promoter of serotonin transporter (5-HTT) gene have been shown as a novel risk factor for sudden infant death syndrome (SIDS)...
  43. ncbi Sudden infant death syndrome in twins and singletons
    Peter O D Pharoah
    Department of Public Health, University of Liverpool, Liverpool, United Kingdom
    Twin Res Hum Genet 10:644-8. 2007
    ..The aim of this study is to investigate whether zygosity is a risk factor for the sudden infant death syndrome (SIDS)...
  44. ncbi Risk factors, diagnosis and prevention of sudden unexpected infant death
    Akihiro Takatsu
    Department of Forensic Medicine, Jikei University School of Medicine, 3 25 8, Nishi Shinbashi, Minato ku, Tokyo 105 8461, Japan
    Leg Med (Tokyo) 9:76-82. 2007
    ..During the sudden infant death syndrome (SIDS) epidemic, many reports described the risk factors of SIDS as well as mechanical suffocation ..
  45. ncbi Sudden fetal and infant deaths: shared characteristics and distinctive features
    William P Fifer
    Department Psychiatry, Columbia University, and Psychiatric Institute New York, 10032, USA
    Semin Perinatol 26:89-96. 2002
    Recent evidence suggests sudden infant death syndrome (SIDS) infants have a diminished capacity to respond to autonomic challenges during a vulnerable developmental period...
  46. ncbi Repeat sudden unexpected and unexplained infant deaths: natural or unnatural?
    R G Carpenter
    Medical Statistics Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Lancet 365:29-35. 2005
    ..We aimed to estimate the probability that a second infant death is natural versus unnatural...
  47. ncbi Heterozygous nonsense SCN5A mutation W822X explains a simultaneous sudden infant death syndrome
    Emanuela Turillazzi
    Department of Forensic Pathology, University of Foggia, Ospedale Colonnello D Avanzo, Viale degli Aviatori 1, 71100, Foggia, Italy
    Virchows Arch 453:209-16. 2008
    The sudden, unexpected, and unexplained death of both members of a set of healthy twins (simultaneous sudden infant death syndrome (SSIDS)) is defined as a case in which both infants meet the definition of sudden infant death syndrome ..
  48. ncbi Prenatal to early postnatal nicotine exposure impairs central chemoreception and modifies breathing pattern in mouse neonates: a probable link to sudden infant death syndrome
    Jaime Eugenin
    Laboratory of Neural Systems, Department of Biology, Faculty of Chemistry and Biology, Universidad de Santiago de Chile, Santiago 9160000, Chile
    J Neurosci 28:13907-17. 2008
    Nicotine is a neuroteratogen and is the likely link between maternal cigarette smoking during pregnancy and sudden infant death syndrome (SIDS)...
  49. doi Sudden infant death syndrome (SIDS) and child care centres (CCC)
    U Kiechl-Kohlendorfer
    Department of Paediatrics, Division of Neonatology, Neuropaediatrics and Metabolic Diseases, Innsbruck Medical University, Innsbruck, Austria
    Acta Paediatr 97:844-5. 2008
    Our aim was to review the risk of sudden infant death syndrome (SIDS) when infants are in child care (CC), to discuss factors potentially responsible for SIDS in this setting and to describe the impact of previous information campaigns ..
  50. ncbi Unexplained infant and child death: a review of sudden infant death syndrome, sudden unexplained infant death, and child maltreatment fatalities including shaken baby syndrome
    Alice W Newton
    Department of Pediatrics, Harvard Medical School, and the Child Protection Program of Massachusetts General Hospital, Boston, Massachusetts 02115, USA
    Curr Opin Pediatr 18:196-200. 2006
    This review will examine the most recent published literature on Sudden Infant Death, Sudden Unexplained Infant Death, infant and child death due to maltreatment, and Shaken Baby Syndrome.
  51. ncbi Molecular typing of Pneumocystis jirovecii found in formalin-fixed paraffin-embedded lung tissue sections from sudden infant death victims
    M Chabé
    Ecology of Parasitism, EA 3609 IFR17, Pasteur Institute of Lille, 1 rue du Professeur Calmette BP245, 59019 Lille, France
    Microbiology 150:1167-72. 2004
    ..studies have provided histological evidence of an association between primary Pneumocystis infection and sudden infant death syndrome (SIDS)...
  52. pmc Sudden infant death syndrome and sleeping position in pre-term and low birth weight infants: an opportunity for targeted intervention
    P S Blair
    Institute of Child Life and Health, Department of Clinical Science, South Bristol, University of Bristol, UK
    Arch Dis Child 91:101-6. 2006
    To determine the combined effects of sudden infant death syndrome (SIDS) risk factors in the sleeping environment for infants who were "small at birth" (pre-term (<37 weeks), low birth weight (<2500 g), or both).
  53. ncbi NHE3 in the human brainstem: implication for the pathogenesis of the sudden infant death syndrome (SIDS)?
    Martin Wiemann
    University of Duisburg Essen, Department of Physiology
    Adv Exp Med Biol 605:508-13. 2008
    ..As an insufficient drive to breath may be a final event causing sudden infant death, we compared the expression of NHE3 mRNA in a collective of children who died from non-natural causes to an ..
  54. ncbi Sudden unexpected infant death and bedsharing: referrals to the Wellington Coroner 1997-2006
    Alistair Escott
    School of Medicine andHealth Sciences, University of Otago, Wellington, PO Box 7343, Wellington, New Zealand
    N Z Med J 122:59-68. 2009
    ..To describe the factors associated with sudden unexpected infant deaths, for which there was no clear medical diagnosis, referred to the Wellington-based coronial paediatric pathology service over the decade from 1997 to 2006...
  55. ncbi The contribution of prone sleeping position to the racial disparity in sudden infant death syndrome: the Chicago Infant Mortality Study
    Fern R Hauck
    Department of Family Medicine, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA
    Pediatrics 110:772-80. 2002
    Rates of sudden infant death syndrome (SIDS) are over twice as high among African Americans compared with Caucasians...
  56. doi Sudden unexpected death in infancy in Denmark
    Bo Gregers Winkel
    The Danish National Research Foundation Centre for Cardiac Arrhythmia DARC, Copenhagen, Denmark
    Scand Cardiovasc J 45:14-20. 2011
    Incidence of sudden unexpected death in infancy (SUDI) and sudden infant death syndrome (SIDS) differs among studies and non-autopsied cases are difficult to assess.
  57. ncbi Lung tissue concentrations of nicotine in sudden infant death syndrome (SIDS)
    Kristen I McMartin
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Pediatr 140:205-9. 2002
    To compare lung concentrations of nicotine and cotinine in cases of sudden infant death syndrome (SIDS) and controls.
  58. ncbi Sudden Infant Death Syndrome and the time of death: factors associated with night-time and day-time deaths
    P S Blair
    Institute of Child Life and Health, Department of Clinical Science, South Bristol, University of Bristol, UK
    Int J Epidemiol 35:1563-9. 2006
    To investigate the diurnal occurrence of Sudden Infant Death Syndrome (SIDS) and interaction with established risk factors in the infant sleeping environment.
  59. ncbi Genetics of the sudden infant death syndrome
    Cornelius Courts
    Institute of Forensic Medicine, University of Bonn, Bonn, Germany
    Forensic Sci Int 203:25-33. 2010
    The sudden infant death syndrome (SIDS) is currently defined as "the sudden unexpected death of an infant less than 1 year of age with onset of the fatal episode apparently occurring during sleep, that remains unexplained after a ..
  60. ncbi Mother-infant cosleeping, breastfeeding and sudden infant death syndrome: what biological anthropology has discovered about normal infant sleep and pediatric sleep medicine
    James J McKenna
    Department of Anthropology and Mother Baby Behavioral Sleep Laboratory, University of Notre Dame, Notre Dame, IN 46556, USA
    Am J Phys Anthropol . 2007
    ....
  61. pmc The value of a thorough protocol in the investigation of sudden infant deaths
    D W Sadler
    University Department of Forensic Medicine, Dundee Royal Infirmary, UK
    J Clin Pathol 51:689-94. 1998
    ..To review the diagnostic value of using a thorough necropsy protocol for the investigation of sudden infant deaths, with particular emphasis on the value of routine ancillary laboratory investigations...
  62. ncbi Cardiovascular control during sleep in infants: Implications for Sudden Infant Death Syndrome
    Rosemary S C Horne
    Ritchie Centre for Baby Health Research, Monash Institute of Medical Research, Monash University, Melbourne, Australia
    Sleep Med 11:615-21. 2010
    ..failure of cardiovascular control mechanisms in particular is believed to play a role in the final event of Sudden Infant Death Syndrome (SIDS)...
  63. doi Cardiac ion channel mutations in the sudden infant death syndrome
    Eva C Klaver
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Int J Cardiol 152:162-70. 2011
    b>Sudden infant death syndrome (SIDS) is characterized by the sudden death of an infant that occurs during sleep and remains unexplained despite thorough examination...
  64. doi Evidence for an association between infant mortality and a carnitine palmitoyltransferase 1A genetic variant
    Bradford D Gessner
    Alaska Division of Public Health, PO Box 240249, Suite 354, Anchorage, AK 99524, USA
    Pediatrics 126:945-51. 2010
    ..1436C→T) in the gene coding for carnitine palmitoyltransferase type 1A (CPT1A). We sought to determine whether these 2 findings were related...
  65. ncbi [Epidemiology of 25 years of crib death (sudden infant death syndrome) in the Netherlands; incidence of crib death and prevalence of risk factors in 1980-2004]
    G A de Jonge
    Centraal Bureau voor de Statistiek, Voorburg
    Ned Tijdschr Geneeskd 149:1273-8. 2005
    To describe the prevalence of risk factors and the incidence of cot death (sudden infant death syndrome; SIDS) in the Netherlands during the last 25 years.
  66. pmc Sudden Infant Death Syndrome and prenatal maternal smoking: rising attributed risk in the Back to Sleep era
    Mark E Anderson
    Department of Community Health Services, Division of Pediatrics, Denver Health and Hospitals Authority, Denver, Colorado, USA
    BMC Med 3:4. 2005
    Parental smoking and prone sleep positioning are recognized causal features of Sudden Infant Death. This study quantifies the relationship between prenatal smoking and infant death over the time period of the Back to Sleep campaign in ..
  67. ncbi Sudden infant death syndrome and maternal depression
    Louise M Howard
    Health Services and Population Research Department, Institute of Psychiatry, United Kingdom
    J Clin Psychiatry 68:1279-83. 2007
    To investigate whether there is an association between sudden infant death syndrome (SIDS) and perinatal depression.
  68. ncbi Exposure to cigarette smoke, a major risk factor for sudden infant death syndrome: effects of cigarette smoke on inflammatory responses to viral infection and bacterial toxins
    M W Raza
    Department of Medical Microbiology, University of Edinburgh, Medical School, UK
    FEMS Immunol Med Microbiol 25:145-54. 1999
    Exposure to cigarette smoke is a major risk factor for sudden infant death syndrome and also for respiratory infections in children...
  69. ncbi Stable prevalence but changing risk factors for sudden infant death syndrome in child care settings in 2001
    Rachel Y Moon
    Division of General Pediatrics and Community Health, Goldberg Center for Community Pediatric Health, Washington, DC, USA
    Pediatrics 116:972-7. 2005
    A total of 20% of sudden infant death syndrome (SIDS) cases in the 1990s occurred in child care settings. This is much higher than the 8% expected from Census Bureau data...
  70. ncbi Sudden infant death syndrome: overview and update
    Roger W Byard
    Division of Pathology, Forensic Science Centre, 21 Divett Place, Adelaide 5000, South Australia, Australia
    Pediatr Dev Pathol 6:112-27. 2003
    The past decade and a half has seen marked changes in the epidemiology of sudden infant death syndrome (SIDS)...
  71. pmc Recommendations for sudden infant death syndrome prevention: a discussion document
    E A Mitchell
    Department of Paediatrics, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Arch Dis Child 92:155-9. 2007
    This article reviews the evidence for the current UK Department of Health recommendations for prevention of sudden infant death syndrome (SIDS) and suggests other factors that should be considered...
  72. ncbi Unexplained sudden death, including sudden infant death syndrome (SIDS), in the first and second years of life: case definition and guidelines for collection, analysis, and presentation of immunization safety data
    Gerhard Jorch
    University of Magdeburg, Magdeburg, Germany
    Vaccine 25:5707-16. 2007
  73. doi Sterile site infection at autopsy in sudden unexpected deaths in infancy
    P N Goldwater
    The Women s and Children s Hospital, and The University of Adelaide Discipline of Paediatrics, Children, Youth and Women s Health Service, 72 King William Road, North Adelaide, South Australia 5006, Australia
    Arch Dis Child 94:303-7. 2009
    ..To examine and compare bacteriological findings at autopsy of cases of sudden unexpected infant death and those of deaths from other cause...
  74. pmc Sudden infant death syndrome: a critical review of approaches to research
    P N Goldwater
    Microbiology and Infectious Diseases Department, The Women s and Children s Hospital, North Adelaide, South Australia 5006
    Arch Dis Child 88:1095-100. 2003
    ..Close examination of the pathological clues would provide better insights into the mechanisms underlying this enigmatic and heartbreaking problem...
  75. pmc Small for gestational age infants and sudden infant death syndrome: a confluence of complex conditions
    Carl E Hunt
    Chevy Chase, Maryland 20815, USA
    Arch Dis Child Fetal Neonatal Ed 92:F428-9. 2007
  76. ncbi Changing conclusions on secondhand smoke in a sudden infant death syndrome review funded by the tobacco industry
    Elisa K Tong
    Division of General Internal Medicine Fellowship Program, Cardiovascular Research Institute, University of California, San Francisco, California 94143 1390, USA
    Pediatrics 115:e356-66. 2005
    ..Secondhand smoke (SHS) has been linked causally with sudden infant death syndrome (SIDS) in major health reports...
  77. doi Staphylococcal enterotoxin genes are common in Staphylococcus aureus intestinal flora in Sudden Infant Death Syndrome (SIDS) and live comparison infants
    Amanda R Highet
    Department of Microbiology and Infectious Diseases, SA Pathology at the Women s and Children s Hospital, North Adelaide, SA, Australia
    FEMS Immunol Med Microbiol 57:151-5. 2009
    Pathological and epidemiological findings in sudden infant death syndrome (SIDS) suggest an infectious aetiology with indications of involvement of staphylococcal enterotoxins (SEs)...
  78. ncbi Incongruent cerebral growth in sudden infant death syndrome
    Hazim Kadhim
    Anatomic Pathology Service, Brugmann University Hospital, Brussels, Belgium
    J Child Neurol 20:244-6. 2005
    b>Sudden infant death syndrome remains a leading cause of post-neonatal mortality in developed countries. Its etiopathogenic mechanisms are unknown...
  79. ncbi Myocardial inflammation, cellular death, and viral detection in sudden infant death caused by SIDS, suffocation, or myocarditis
    Henry F Krous
    Department of Pathology, University of California San Diego, La Jolla, CA 92037, USA
    Pediatr Res 66:17-21. 2009
    ..Very mild myocardial lymphocyte and macrophage infiltration and scattered necrotic cardiomyocytes in SIDS are not pathologic, but may occur after the developing heart is exposed to environmental pathogens, including viruses...
  80. doi Immunohistochemical and molecular-pathological diagnosis of myocarditis in cases of suspected sudden infant death syndrome (SIDS)--a multicenter study
    Reinhard Dettmeyer
    Institute of Forensic Medicine, University of Giessen, Frankfurter Street 58, D 35392 Giessen, Germany
    Leg Med (Tokyo) 11:S124-7. 2009
    ..Preliminary criteria for cellular immunohistochemical diagnosis of viral myocardial affections derived from these findings were suggested...
  81. doi Intrathoracic petechiae in SIDS: a retrospective population-based 15-year study
    Henry F Krous
    Rady Children s Hospital San Diego, 3020 Children s Way, M5007, San Diego, CA 92123, USA
    Forensic Sci Med Pathol 4:234-9. 2008
    Intrathoracic petechiae (IP), the most common gross finding in sudden infant death syndrome (SIDS) cases at autopsy, suggest upper airway obstruction (UAO) occurs during the terminal event...
  82. ncbi Novel hypothesis for unexplained sudden unexpected death in infancy (SUDI)
    A R Highet
    Department of Microbiology and Infectious Diseases, SA Pathology, Women s and Children s Hospital, North Adelaide, South Australia, Australia
    Arch Dis Child 94:841-3. 2009
    ..The objective was to assess these observations in the context of the pathology and epidemiology of sudden infant death syndrome (SIDS) in relation to the role of infection and inflammation as triggers of these deaths.
  83. ncbi Sudden infant death syndrome (SIDS) shortly after hexavalent vaccination: another pathology in suspected SIDS?
    Giulia Ottaviani
    Institute of Pathology, University of Milan, Via della Commenda 19, Milan 20122, Italy
    Virchows Arch 448:100-4. 2006
    ..Participants included pathologists with experience in the field of vaccines and sudden infant death syndrome who conducted autopsies...
  84. ncbi The role of respiratory control disorders in SIDS
    Bradley T Thach
    Department of Pediatrics, Washington University School of Medicine, 660 S Euclid, Campus Box 8208, St Louis, MO 63110, USA
    Respir Physiol Neurobiol 149:343-53. 2005
    ..In drawing conclusions it is well to recognize that mechanisms leading to death in SIDS are heterogeneous and therefore there is room for several plausible theories for respiratory or circulatory abnormalities contributing to SIDS...
  85. ncbi Sudden infant death syndrome: no increased risk after immunisation
    M M T Vennemann
    Institute of Legal Medicine, University of Munster, and Children s Hospital, University of Magdeburg, Germany
    Vaccine 25:336-40. 2007
    ....
  86. ncbi Prevalence of congenital adrenal hyperplasia among sudden infant death in the Czech Republic and Austria
    Kristina A Strnadová
    Department of Pediatrics, 3rd Faculty of Medicine, Charles University, CZ 100 81, Prague, Czech Republic
    Eur J Pediatr 166:1-4. 2007
    ..Hence, newborn screening would have prevented these deaths had it been available. In addition, we have shown that the I2 point mutation that is expected to lead to simple virilizing form may lead to a fatal outcome...
  87. ncbi Why babies should never sleep alone: a review of the co-sleeping controversy in relation to SIDS, bedsharing and breast feeding
    James J McKenna
    University of Notre Dame, Notre Dame, Indiana, IN 46556, USA
    Paediatr Respir Rev 6:134-52. 2005
    ....
  88. pmc Hypoplasia and neuronal immaturity of the hypoglossal nucleus in sudden infant death
    G Ottaviani
    Institute of Pathology, Lino Rossi Research Centre for the study and prevention of unexpected perinatal death and SIDS, University of Milan, Italy
    J Clin Pathol 59:497-500. 2006
    ..Her sudden death offered a unique insight into the possible role of delayed neuronal maturation and hypoplasia of the hypoglossal nucleus in representing a likely morphological substrate of sudden death...
  89. doi Organ weights in cases of sudden infant death syndrome: a German study
    Tony Fracasso
    Institute of Legal Medicine, University of Munster, Germany
    Am J Forensic Med Pathol 30:231-4. 2009
    Despite its decreasing incidence, sudden infant death syndrome (SIDS) still remains an important cause of death in infancy. Since Felix Platter described the case of a child suffocated because of a massive goiter (Platter E...
  90. doi Serotypes of Escherichia coli in sudden infant death syndrome
    J L Pearce
    Department of Agricultural Sciences, La Trobe University, Melbourne, Vic, Australia
    J Appl Microbiol 108:731-5. 2010
    To examine the diversity of Escherichia coli serotypes found in the intestinal contents of infants who died of Sudden Infant Death Syndrome (SIDS) compared with that in comparison infants.
  91. ncbi Rebreathing of exhaled gases: importance as a mechanism for the causal association between prone sleep and sudden infant death syndrome
    J S Kemp
    Division of Pulmonary Medicine, St. Louis Children's Hospital, St. Louis, Missouri 63110, USA
    Sleep 19:S263-6. 1996
    Twenty to 52% of sudden infant death syndrome (SIDS) victims are found dead with their noses and mouths turned into underlying bedding...
  92. ncbi What is the mechanism of sudden infant deaths associated with co-sleeping?
    Christine G McIntosh
    Dept of Physiology, University of Auckland, Private Bag 92019, Auckland 1023, New Zealand
    N Z Med J 122:69-75. 2009
    The risk of Sudden Infant Death Syndrome (SIDS) has fallen dramatically in the "Back to Sleep" era; however, half the cases now occur when the infant has been sleeping in bed with another person...
  93. ncbi Elevated serum concentrations of beta-tryptase, but not alpha-tryptase, in Sudden Infant Death Syndrome (SIDS). An investigation of anaphylactic mechanisms
    M G Buckley
    Immunopharmacology Group, Southampton General Hospital, Southampton, UK
    Clin Exp Allergy 31:1696-704. 2001
    BACKGROUND: Sudden Infant Death Syndrome, (SIDS) or cot death, remains the most common category of post-perinatal death in the UK...
  94. doi Interleukin-2 as a neuromodulator possibly implicated in the physiopathology of sudden infant death syndrome
    Hazim Kadhim
    Neuropathology Unit, Department of Anatomic Pathology, Centre Hospitalier Universitaire Brugmann, Universite Libre De Bruxelles U L B, Place Van Gehuchten 4, 1020 Brussels, Belgium
    Neurosci Lett 480:122-6. 2010
    ..centers, including those controlling cardiorespiratory- and sleep/arousal pathophysiology, is reported in sudden infant death syndrome (SIDS). Biological mechanisms underlying SIDS, however, remain unclear...
  95. ncbi Sudden infant death syndrome--a defect in circulatory control?
    T Matthews
    University College Dublin, Department of Paediatrics, Temple Street Children s Hospital and The Rotunda Hospital, Dublin, Ireland
    Child Care Health Dev 28:41-3. 2002
    The majority of Sudden Infant Death Syndrome (SIDS) infants die during sleep and especially during the overnight sleep period...
  96. ncbi Heart weight in infants--a comparison between sudden infant death syndrome and other causes of death
    P Råsten-Almqvist
    Department of Forensic Medicine, Karolinska Institute, Stockholm, Sweden
    Acta Paediatr 89:1062-7. 2000
    ..1998, out of 468 infants autopsied at the Department of Forensic Medicine in Stockholm, Sweden, 331 died of sudden infant death syndrome (SIDS), while 137 died of other causes...
  97. doi Concurrent risks in sudden infant death syndrome
    Barbara M Ostfeld
    University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Department of Pediatrics, PO Box 19, New Brunswick, NJ 08903, USA
    Pediatrics 125:447-53. 2010
    Despite improved education on safe sleep, infants are still exposed to multiple risks for sudden infant death syndrome (SIDS)...
  98. pmc Critical diaphragm failure in sudden infant death syndrome
    Pontus Max Axel Siren
    JGK Memorial Research Library, Snellmanin k 15, 00170, Helsinki, Finland
    Ups J Med Sci 116:115-23. 2011
    b>Sudden infant death syndrome (SIDS) is the leading cause of death in infants between the ages of 1 and 12 months in developed countries. SIDS is by definition a diagnosis of exclusion, and its mechanism of action is unknown...
  99. ncbi Sudden infant death syndrome, bedsharing, parental weight, and age at death
    C Carroll-Pankhurst
    Mandel School of Applied Social Sciences, Case Western Reserve University, Cleveland, Ohio 44106 4945, USA
    Pediatrics 107:530-6. 2001
    To assess the role of parental bedsharing in sudden infant death syndrome (SIDS)-like deaths, this study examines the hypothesis that, compared with other SIDS cases, the age distribution of deaths associated with bedsharing should be ..
  100. ncbi Birth weight- and gestational age-specific sudden infant death syndrome mortality: United States, 1991 versus 1995
    M H Malloy
    Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas 77555 0526, USA
    Pediatrics 105:1227-31. 2000
    To estimate the changes in birth weight- and gestational age-specific sudden infant death syndrome (SIDS) mortality rates since the publication of the sleep-positioning recommendations by the American Academy of Pediatrics Task Force on ..
  101. pmc Effects of the supine and prone position on diaphragm thickness in healthy term infants
    V K Rehan
    Department of Pediatrics, Memorial Hospital of Rhode Island, Pawtucket, Rhode Island, USA
    Arch Dis Child 83:234-8. 2000
    The physiological basis underlying the decline in the incidence of sudden infant death syndrome (SIDS) associated with changing the sleep position from prone to supine remains unknown.

Research Grants80

  1. The Ventral Medulla and the Sudden Infant Death Syndrome
    Hannah Kinney; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Despite the success of the Back-to-Sleep campaign, the sudden infant death syndrome (SIDS) remains the leading cause of postneonatal infant mortality in the United States today...
  2. The Ventral Medulla and the Sudden Infant Death Syndrome
    Hannah Kinney; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Despite the success of the Back-to-Sleep campaign, the sudden infant death syndrome (SIDS) remains the leading cause of postneonatal infant mortality in the United States today...
  3. Neonatal Long QT Syndrome and Sudden Infant Death
    ALFRED GEORGE; Fiscal Year: 2009
    ..In neonates and infants, sudden unexplained death is classified as the sudden infant death syndrome (SIDS) when rigorous efforts to identify the cause of death including a forensic examination are ..
  4. Neonatal Long QT Syndrome and Sudden Infant Death
    ALFRED GEORGE; Fiscal Year: 2007
    ..In neonates and infants, sudden unexplained death is classified as the sudden infant death syndrome (SIDS) when rigorous efforts to identify the cause of death including a forensic examination are ..
  5. Neonatal Long QT Syndrome and Sudden Infant Death
    Alfred L George; Fiscal Year: 2010
    ..In neonates and infants, sudden unexplained death is classified as the sudden infant death syndrome (SIDS) when rigorous efforts to identify the cause of death including a forensic examination are ..
  6. CHOLINERGIC MECHANISMS OF BREATHING DURING SLEEP
    Ralph Lydic; Fiscal Year: 1990
    ..The sleep apnea syndromes have been estimated to affect 1 to 5% of the older adult male population, while the sudden infant death syndrome (SIDS) is the leading cause of death in infants between 1 month and 1 year of age...
  7. Coordination of orofacial and respiratory movements
    Detlef Heck; Fiscal Year: 2009
    ..in coordinating orofacial and respiratory movements are implicated in human health conditions such as sudden infant death syndrome (SIDS), swallowing dysfunction (dysphagia) and speech disorders (dysarthria)...
  8. Coordination of orofacial and respiratory movements
    Detlef H Heck; Fiscal Year: 2010
    ..in coordinating orofacial and respiratory movements are implicated in human health conditions such as sudden infant death syndrome (SIDS), swallowing dysfunction (dysphagia) and speech disorders (dysarthria)...
  9. Nicotine Modulation of Parasympathetic Cardiac Neurons
    David Mendelowitz; Fiscal Year: 2009
    ..However an exaggerated diving reflex has been implicated in sudden infant death syndrome (SIDS). SIDS is the leading cause of death among infants who are 1 month to 1 year old...
  10. MOLECULAR STRUCTURE OF THE 900 KD BOTULINUM NEUROTOXIN COMPLEX
    RAYMOND STEVENS; Fiscal Year: 2001
    ..Botulinum neurotoxin type A (BoNT/A) is a potent disease agent in both food-borne botulism and Sudden Infant Death Syndrome (SIDS), an established biological weapon, and a novel therapeutic in the treatment of involuntary ..
  11. MOLECULAR STRUCTURE OF THE 900 KD BOTULINUM NEUROTOXIN COMPLEX
    RAYMOND STEVENS; Fiscal Year: 2001
    ..Botulinum neurotoxin type A (BoNT/A) is a potent disease agent in both food-borne botulism and Sudden Infant Death Syndrome (SIDS), an established biological weapon, and a novel therapeutic in the treatment of involuntary ..
  12. MOLECULAR STRUCTURE OF THE 900 KD BOTULINUM NEUROTOXIN COMPLEX
    RAYMOND STEVENS; Fiscal Year: 2002
    ..Botulinum neurotoxin type A (BoNT/A) is a potent disease agent in both food-borne botulism and Sudden Infant Death Syndrome (SIDS), an established biological weapon, and a novel therapeutic in the treatment of involuntary ..
  13. MOLECULAR STRUCTURE OF THE 900 KD BOTULINUM NEUROTOXIN COMPLEX
    RAYMOND STEVENS; Fiscal Year: 1999
    ..Botulinum neurotoxin type A (BoNT/A) is a potent disease agent in both food-borne botulism and Sudden Infant Death Syndrome (SIDS), an established biological weapon, and a novel therapeutic in the treatment of involuntary ..
  14. MOLECULAR STRUCTURE OF THE 900 KD BOTULINUM NEUROTOXIN COMPLEX
    RAYMOND STEVENS; Fiscal Year: 2002
    ..Botulinum neurotoxin type A (BoNT/A) is a potent disease agent in both food-borne botulism and Sudden Infant Death Syndrome (SIDS), an established biological weapon, and a novel therapeutic in the treatment of involuntary ..
  15. MOLECULAR STRUCTURE OF THE 900 KD BOTULINUM NEUROTOXIN COMPLEX
    RAYMOND STEVENS; Fiscal Year: 2000
    ..Botulinum neurotoxin type A (BoNT/A) is a potent disease agent in both food-borne botulism and Sudden Infant Death Syndrome (SIDS), an established biological weapon, and a novel therapeutic in the treatment of involuntary ..
  16. MOLECULAR STRUCTURE OF THE 900 KD BOTULINUM NEUROTOXIN COMPLEX
    RAYMOND STEVENS; Fiscal Year: 1999
    ..Botulinum neurotoxin type A (BoNT/A) is a potent disease agent in both food-borne botulism and Sudden Infant Death Syndrome (SIDS), an established biological weapon, and a novel therapeutic in the treatment of involuntary ..
  17. Sleep, Arousal, and Spontaneous Movements in Opioid Exposed Infants
    Marie Hayes; Fiscal Year: 2009
    ..Our preliminary studies in apneic and alcohol-exposed infants at high risk for Sudden Infant Death Syndrome (SIDS) revealed reduced vigor in SM burst duration compared to normative samples...
  18. Sleep, Arousal, and Spontaneous Movements in Opioid Exposed Infants
    Marie J Hayes; Fiscal Year: 2010
    ..Our preliminary studies in apneic and alcohol-exposed infants at high risk for Sudden Infant Death Syndrome (SIDS) revealed reduced vigor in SM burst duration compared to normative samples...
  19. Screening for Jervell and Lange-Nielsen Syndrome
    Ruey Kang R Chang; Fiscal Year: 2010
    ..Sudden cardiac death of infants with undiagnosed JLNS is often reported as sudden infant death syndrome (SIDS)...
  20. Screening for Jervell and Lange-Nielsen Syndrome
    Ruey Kang Chang; Fiscal Year: 2009
    ..Sudden cardiac death of infants with undiagnosed JLNS is often reported as sudden infant death syndrome (SIDS)...
  21. Predictors of Prenatal Care Providers Counseling Women on Tobacco Use/Exposure
    BETH LEONG PINELES; Fiscal Year: 2012
    ..Low birthweight, preterm birth, stillbirth, and sudden infant death syndrome are among the most prominent effects of maternal smoking and secondhand smoke exposure during ..
  22. High Throughput Methods to Measure Disparities in Childhood Exposure to Tobacco
    ANNE JOSEPH; Fiscal Year: 2009
    ..birth- weight, asthma induction, asthma exacerbation, increased ear and lower respiratory infections, and sudden infant death syndrome. Notably, SHS exposure and the health effects of SHS vary by race, ethnicity and SES...
  23. High Throughput Methods to Measure Disparities in Childhood Exposure to Tobacco
    Sharon E Murphy; Fiscal Year: 2010
    ..birth- weight, asthma induction, asthma exacerbation, increased ear and lower respiratory infections, and sudden infant death syndrome. Notably, SHS exposure and the health effects of SHS vary by race, ethnicity and SES...
  24. MECHANISM OF CARDIORESPIRATORY RHYTHM IN NEONATES
    David Mendelowitz; Fiscal Year: 2009
    ..However an exaggerated diving reflex has been implicated in sudden infant death syndrome (SIDS)...
  25. MECHANISM OF CARDIORESPIRATORY RHYTHM IN NEONATES
    David Mendelowitz; Fiscal Year: 2011
    ..However an exaggerated diving reflex has been implicated in sudden infant death syndrome (SIDS)...
  26. MECHANISM OF CARDIORESPIRATORY RHYTHM IN NEONATES
    David Mendelowitz; Fiscal Year: 2010
    ..However an exaggerated diving reflex has been implicated in sudden infant death syndrome (SIDS)...
  27. Developmental Genetics of Serotonin Neuron Subtypes in Brain Reward Circuits
    Susan Dymecki; Fiscal Year: 2007
    ..pathological anxiety, to childhood developmental disorders such as autism, fetal alcohol syndrome, and the sudden infant death syndrome. Each disorder differs in clinical feature, suggesting heterogeneity in serotonin neuron function...
  28. Transport of gene silencing between cells during RNA interference
    Antony Merlin Jose; Fiscal Year: 2010
    ..elegans will provide valuable insights to overcome these barriers to therapeutic RNAi in humans. ..
  29. Gene Therapy for Lung and Cardiovascular Disease
    Nicholas Muzyczka; Fiscal Year: 2002
    ..a relatively common class of metabolic disorders, the most common of which typically present with either Sudden Infant Death Syndrome (SIDS) or with a combined cardiac and skeletal myopathy...
  30. The upper airway and the Sudden Infant Death Syndrome
    Donald Bartlett; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The incidence of the Sudden Infant Death Syndrome (SIDS) has decreased substantially in the United States and elsewhere as a result of educational campaigns favoring the supine posture for sleeping ..
  31. The upper airway and the Sudden Infant Death Syndrome
    Donald Bartlett; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The incidence of the Sudden Infant Death Syndrome (SIDS) has decreased substantially in the United States and elsewhere as a result of educational campaigns favoring the supine posture for sleeping ..
  32. Mu Opioid Receptor Regulation in Neonatal Brainstem
    GEORGE OLSEN; Fiscal Year: 2005
    ..These neonates exhibit withdrawal hyperventilation and an increased incidence of sudden infant death syndrome (SIDS)...
  33. STRUCTURAL STUDIES OF SUPERANTIGENS
    Douglas Ohlendorf; Fiscal Year: 1999
    ..food poisoning, toxic shock syndrome, scarlet and rheumatic fever, arthritis, multiple sclerosis, diabetes, sudden infant death syndrome, Kawasaki syndrome (a leading cause of acquired heart defects), and MDS...
  34. Improving the Self-Efficacy of African American Parents in Infant Supine Sleep
    Kathryn L Moseley; Fiscal Year: 2010
    ..African American infants also die of Sudden Infant Death Syndrome (SIDS) at rates 2-3 times greater than non-Hispanic White infants...
  35. ETHICAL & SOCIAL IMPLICATIONS OF GENETIC TESTING IN THE CASE OF UNEXPECTED DEATHS
    Siobhan Dolan; Fiscal Year: 2009
    ..this project are: 1) To evaluate and systematize ethical and social issues associated with investigation of sudden infant death syndrome (SIDS) and sudden unexplained death syndrome (SUDS) that reveals a molecular cardiogenetic cause ..
  36. TELEMICROSCOPY & DISTRIBUTED PROCESSING
    Stephen Young; Fiscal Year: 2001
    ....
  37. TELEMICROSCOPY & DISTRIBUTED PROCESSING
    Stephen Young; Fiscal Year: 2001
    ....
  38. TELEMICROSCOPY & DISTRIBUTED PROCESSING
    Stephen Young; Fiscal Year: 1999
    ....
  39. TELEMICROSCOPY & DISTRIBUTED PROCESSING
    Stephen Young; Fiscal Year: 2000
    ....
  40. ETHICAL & SOCIAL IMPLICATIONS OF GENETIC TESTING IN THE CASE OF UNEXPECTED DEATHS
    Siobhan M Dolan; Fiscal Year: 2010
    ..this project are: 1) To evaluate and systematize ethical and social issues associated with investigation of sudden infant death syndrome (SIDS) and sudden unexplained death syndrome (SUDS) that reveals a molecular cardiogenetic cause ..
  41. TELEMICROSCOPY & DISTRIBUTED PROCESSING
    Stephen Young; Fiscal Year: 2001
    ....
  42. TELEMICROSCOPY & DISTRIBUTED PROCESSING
    Stephen Young; Fiscal Year: 2002
    ....
  43. Identification of Factors Influencing Climbing Fiber Neuron Fate in the Dorsal Hi
    REBECCA LANDSBERG; Fiscal Year: 2009
    ..documented in association with a number of inherited ataxic syndromes, autism, fetal alcohol syndrome, and sudden infant death syndrome (SIDS), the leading cause of infant mortality in the United States...
  44. ADENOSINE RECEPTORS AND THE PATHOPHYSIOLOGY OF SIDS
    H Zielke; Fiscal Year: 1990
    Abnormal respiratory control has been cited as a possible cause of death of infants dying from the Sudden Infant Death Syndrome (SIDS)...
  45. PROFILING THE NEEDS OF DYING CHILDREN
    JOHN FEUDTNER; Fiscal Year: 2004
    ..As deaths due to injury, prematurity, and sudden infant death syndrome are prevented, the remaining deaths may be increasingly associated with chronic conditions...
  46. PROFILING THE NEEDS OF DYING CHILDREN
    JOHN FEUDTNER; Fiscal Year: 2002
    ..As deaths due to injury, prematurity, and sudden infant death syndrome are prevented, the remaining deaths may be increasingly associated with chronic conditions...
  47. PROFILING THE NEEDS OF DYING CHILDREN
    JOHN FEUDTNER; Fiscal Year: 2001
    ..As deaths due to injury, prematurity, and sudden infant death syndrome are prevented, the remaining deaths may be increasingly associated with chronic conditions...
  48. PROFILING THE NEEDS OF DYING CHILDREN
    JOHN FEUDTNER; Fiscal Year: 2003
    ..As deaths due to injury, prematurity, and sudden infant death syndrome are prevented, the remaining deaths may be increasingly associated with chronic conditions...
  49. PROFILING THE NEEDS OF DYING CHILDREN
    JOHN FEUDTNER; Fiscal Year: 2000
    ..As deaths due to injury, prematurity, and sudden infant death syndrome are prevented, the remaining deaths may be increasingly associated with chronic conditions...
  50. Neonatal apnea: Online risk score from new analyses of bedside monitor waveforms
    JOSEPH RANDALL contact MOORMAN; Fiscal Year: 2010
    ..to understand its natural history, its therapy, and its relationship to the major public health problem of sudden infant death syndrome, or SIDS...
  51. Neonatal apnea: Online risk score from new analyses of bedside monitor waveforms
    JOSEPH MOORMAN; Fiscal Year: 2009
    ..to understand its natural history, its therapy, and its relationship to the major public health problem of sudden infant death syndrome, or SIDS...
  52. Developmental defects in serotonin neurons and the response to O2 and CO2
    George Richerson; Fiscal Year: 2007
    b>Sudden infant death syndrome (SIDS) is the most common cause of post neonatal infant death in the U.S. The mechanisms are unknown, but abnormalities in the serotonin system have been consistently found in autopsy studies...
  53. BRAINSTEM MATURATION IN THE SUDDEN INFANT DEATH SYNDROME
    Hannah Kinney; Fiscal Year: 2003
    DESCRIPTION (adapted from applicant's abstract): The sudden infant death syndrome (SIDS) is the leading cause of postneonatal infant mortality, with an overall incidence of 0.8/1000 live births. Its cause(s) is unknown...
  54. NMR STUDIES OF METALS IN KINASES AND RELATED ENZYMES
    Thomas Nowak; Fiscal Year: 1990
    ..The abnormal functioning of these enzymes are implicated in sudden infant death syndrome, secondary metabolic problems in diabetics, anemia and muscle functions...
  55. Developmental defects in serotonin neurons and the response to O2 and CO2
    George Richerson; Fiscal Year: 2009
    b>Sudden infant death syndrome (SIDS) is the most common cause of post neonatal infant death in the U.S. The mechanisms are unknown, but abnormalities in the serotonin system have been consistently found in autopsy studies...
  56. BRAINSTEM MATURATION IN THE SUDDEN INFANT DEATH SYNDROME
    Hannah Kinney; Fiscal Year: 2001
    DESCRIPTION (adapted from applicant's abstract): The sudden infant death syndrome (SIDS) is the leading cause of postneonatal infant mortality, with an overall incidence of 0.8/1000 live births. Its cause(s) is unknown...
  57. NEUROCHEMICAL CONTROL OF RESPIRATION IN SIDS
    Laurence Becker; Fiscal Year: 1990
    b>Sudden infant death syndrome (SIDS) is a leading cause of death under one year of age. Inspite of numerous investigations, the etiology and pathogenesis of SIDS remains unknown...
  58. MODELING OF SIDS IN NEONATAL SWINE
    PHYLLIS GOOTMAN; Fiscal Year: 1991
    Using neonatal swine as our animal model of sudden infant death syndrome (SIDS), we will investigate (using both acute and chronic preparations): 1) postnatal differences in innervation of the heart by vagal and postganglionic ..
  59. Mu Opioid Receptor Regulation in Neonatal Brainstem
    GEORGE OLSEN; Fiscal Year: 2006
    ..These neonates exhibit withdrawal hyperventilation and an increased incidence of sudden infant death syndrome (SIDS)...
  60. Mu Opioid Receptor Regulation in Neonatal Brainstem
    GEORGE OLSEN; Fiscal Year: 2004
    ..These neonates exhibit withdrawal hyperventilation and an increased incidence of sudden infant death syndrome (SIDS)...
  61. Mu Opioid Receptor Regulation in Neonatal Brainstem
    GEORGE OLSEN; Fiscal Year: 2003
    ..These neonates exhibit withdrawal hyperventilation and an increased incidence of sudden infant death syndrome (SIDS)...
  62. ESOPHAGO-LARYNGEAL ADDUCTOR REFLEX
    Nancy Bauman; Fiscal Year: 1999
    ..that bears important similarities with the age predisposition of apparent life-threatening events, and sudden infant death syndrome...
  63. ESOPHAGO-LARYNGEAL ADDUCTOR REFLEX
    Nancy Bauman; Fiscal Year: 2000
    ..that bears important similarities with the age predisposition of apparent life-threatening events, and sudden infant death syndrome...
  64. The Ventral Medulla and the Sudden Infant Death Syndrome
    Hannah Kinney; Fiscal Year: 2004
    Despite an almost 50% decline in the incidence of the sudden infant death syndrome (SIDS) following the 1992 national recommendation for the supine sleep position, SIDS remains the leading cause of postneonatal infant mortality in the ..
  65. The Ventral Medulla and the Sudden Infant Death Syndrome
    Hannah Kinney; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Despite an almost 50% decline in the incidence of the sudden infant death syndrome (SIDS) following the 1992 national recommendation for the supine sleep position, SIDS remains the leading cause of ..
  66. The Ventral Medulla and the Sudden Infant Death Syndrome
    Hannah Kinney; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): Despite an almost 50% decline in the incidence of the sudden infant death syndrome (SIDS) following the 1992 national recommendation for the supine sleep position, SIDS remains the leading cause of ..
  67. The Ventral Medulla and the Sudden Infant Death Syndrome
    Hannah Kinney; Fiscal Year: 2003
    Despite an almost 50% decline in the incidence of the sudden infant death syndrome (SIDS) following the 1992 national recommendation for the supine sleep position, SIDS remains the leading cause of postneonatal infant mortality in the ..
  68. The Ventral Medulla and the Sudden Infant Death Syndrome
    Hannah Kinney; Fiscal Year: 2005
    Despite an almost 50% decline in the incidence of the sudden infant death syndrome (SIDS) following the 1992 national recommendation for the supine sleep position, SIDS remains the leading cause of postneonatal infant mortality in the ..
  69. BRAINSTEM MATURATION IN THE SUDDEN INFANT DEATH SYNDROME
    Hannah Kinney; Fiscal Year: 2009
    The sudden infant death syndrome (SEDS) is the leading cause of postneonatal infant mortality, with an overall incidence of 0.8/1000 live births. Its cause(s) is unknown...
  70. BRAINSTEM MATURATION IN THE SUDDEN INFANT DEATH SYNDROME
    Hannah Kinney; Fiscal Year: 2002
    DESCRIPTION (adapted from applicant's abstract): The sudden infant death syndrome (SIDS) is the leading cause of postneonatal infant mortality, with an overall incidence of 0.8/1000 live births. Its cause(s) is unknown...
  71. BRAINSTEM MATURATION IN THE SUDDEN INFANT DEATH SYNDROME
    Hannah Kinney; Fiscal Year: 2006
    DESCRIPTION (adapted from applicant's abstract): The sudden infant death syndrome (SIDS) is the leading cause of postneonatal infant mortality, with an overall incidence of 0.8/1000 live births. Its cause(s) is unknown...
  72. BRAINSTEM MATURATION IN THE SUDDEN INFANT DEATH SYNDROME
    Hannah Kinney; Fiscal Year: 2004
    DESCRIPTION (adapted from applicant's abstract): The sudden infant death syndrome (SIDS) is the leading cause of postneonatal infant mortality, with an overall incidence of 0.8/1000 live births. Its cause(s) is unknown...
  73. BRAINSTEM MATURATION IN THE SUDDEN INFANT DEATH SYNDROME
    Hannah Kinney; Fiscal Year: 2000
    DESCRIPTION (adapted from applicant's abstract): The sudden infant death syndrome (SIDS) is the leading cause of postneonatal infant mortality, with an overall incidence of 0.8/1000 live births. Its cause(s) is unknown...