sudden infant death

Summary

Summary: The abrupt and unexplained death of an apparently healthy infant under one year of age, remaining unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of the clinical history. (Pediatr Pathol 1991 Sep-Oct;11(5):677-84)

Top Publications

  1. ncbi Cytokine responses and sudden infant death syndrome: genetic, developmental, and environmental risk factors
    C Caroline Blackwell
    Faculty of Health, School of Biomedical Sciences, University of Newcastle and Hunter Medical Research Institute, John Hunter Hospital, Lookout Road, New Lambton, NSW 2300, Australia
    J Leukoc Biol 78:1242-54. 2005
  2. ncbi Prevalence of long-QT syndrome gene variants in sudden infant death syndrome
    Marianne Arnestad
    Institute of Forensic Medicine, University of Oslo, Oslo, Norway
    Circulation 115:361-7. 2007
  3. pmc Sudden infant death syndrome in mice with an inherited mutation in RyR2
    Nitin Mathur
    Department of Molecular Physiology and Biophysics, Division of Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
    Circ Arrhythm Electrophysiol 2:677-85. 2009
  4. ncbi A comparison of the effects of parental risk markers on pre- and perinatal variables in multiple patient cohorts with fetal alcohol syndrome, autism, Tourette syndrome, and sudden infant death syndrome: an enviromic analysis
    Marilyn G Klug
    North Dakota Fetal Alcohol Syndrome Center, School of Medicine and Health Sciences, University of North Dakota, Box 9037, 501 N Columbia Road, Grand Forks, ND 58202 9037, USA
    Neurotoxicol Teratol 25:707-17. 2003
  5. pmc Connexin43 mutation causes heterogeneous gap junction loss and sudden infant death
    David W Van Norstrand
    Mayo Clinic, MN 55905, USA
    Circulation 125:474-81. 2012
  6. pmc A mechanism for sudden infant death syndrome (SIDS): stress-induced leak via ryanodine receptors
    David J Tester
    Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota 55901, USA
    Heart Rhythm 4:733-9. 2007
  7. ncbi Differences in mortality between late-preterm and term singleton infants in the United States, 1995-2002
    Kay M Tomashek
    Maternal and Infant Health Branch, Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Pediatr 151:450-6, 456.e1. 2007
  8. ncbi Recent national trends in sudden, unexpected infant deaths: more evidence supporting a change in classification or reporting
    Carrie K Shapiro-Mendoza
    Maternal and Infant Health Branch, Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA 30341 3717, USA
    Am J Epidemiol 163:762-9. 2006
  9. ncbi Electrospray tandem mass spectrometry for analysis of acylcarnitines in dried postmortem blood specimens collected at autopsy from infants with unexplained cause of death
    D H Chace
    Neo Gen Screening, PO Box 219, Bridgeville, PA 15017, USA
    Clin Chem 47:1166-82. 2001
  10. ncbi [Epidemiology of 25 years of crib death (sudden infant death syndrome) in the Netherlands; incidence of crib death and prevalence of risk factors in 1980-2004]
    G A de Jonge
    Centraal Bureau voor de Statistiek, Voorburg
    Ned Tijdschr Geneeskd 149:1273-8. 2005

Detail Information

Publications316 found, 100 shown here

  1. ncbi Cytokine responses and sudden infant death syndrome: genetic, developmental, and environmental risk factors
    C Caroline Blackwell
    Faculty of Health, School of Biomedical Sciences, University of Newcastle and Hunter Medical Research Institute, John Hunter Hospital, Lookout Road, New Lambton, NSW 2300, Australia
    J Leukoc Biol 78:1242-54. 2005
    Despite the success of the campaigns to reduce the risk of sudden infant death syndrome (SIDS), it still remains the major cause of postneonatal mortality...
  2. ncbi Prevalence of long-QT syndrome gene variants in sudden infant death syndrome
    Marianne Arnestad
    Institute of Forensic Medicine, University of Oslo, Oslo, Norway
    Circulation 115:361-7. 2007
    The hypothesis that some cases of sudden infant death syndrome (SIDS) could be caused by long-QT syndrome (LQTS) has been supported by molecular studies...
  3. pmc Sudden infant death syndrome in mice with an inherited mutation in RyR2
    Nitin Mathur
    Department of Molecular Physiology and Biophysics, Division of Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
    Circ Arrhythm Electrophysiol 2:677-85. 2009
    Mutations in the cardiac ryanodine receptor gene (RyR2) have been recently identified in victims of sudden infant death syndrome...
  4. ncbi A comparison of the effects of parental risk markers on pre- and perinatal variables in multiple patient cohorts with fetal alcohol syndrome, autism, Tourette syndrome, and sudden infant death syndrome: an enviromic analysis
    Marilyn G Klug
    North Dakota Fetal Alcohol Syndrome Center, School of Medicine and Health Sciences, University of North Dakota, Box 9037, 501 N Columbia Road, Grand Forks, ND 58202 9037, USA
    Neurotoxicol Teratol 25:707-17. 2003
    ..were patients from four diagnostic registries in North Dakota for fetal alcohol syndrome (FAS), autism, sudden infant death syndrome (SIDS), and Tourette syndrome...
  5. pmc Connexin43 mutation causes heterogeneous gap junction loss and sudden infant death
    David W Van Norstrand
    Mayo Clinic, MN 55905, USA
    Circulation 125:474-81. 2012
    An estimated 10% to 15% of sudden infant death syndrome (SIDS) cases may stem from channelopathy-mediated lethal arrhythmias...
  6. pmc A mechanism for sudden infant death syndrome (SIDS): stress-induced leak via ryanodine receptors
    David J Tester
    Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota 55901, USA
    Heart Rhythm 4:733-9. 2007
    b>Sudden infant death syndrome (SIDS) is the leading cause of postneonatal mortality in the United States...
  7. ncbi Differences in mortality between late-preterm and term singleton infants in the United States, 1995-2002
    Kay M Tomashek
    Maternal and Infant Health Branch, Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Pediatr 151:450-6, 456.e1. 2007
    ..To assess differences in mortality between late-preterm (34-36 weeks) and term (37-41 weeks) infants...
  8. ncbi Recent national trends in sudden, unexpected infant deaths: more evidence supporting a change in classification or reporting
    Carrie K Shapiro-Mendoza
    Maternal and Infant Health Branch, Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA 30341 3717, USA
    Am J Epidemiol 163:762-9. 2006
    The recent US decline in sudden infant death syndrome (SIDS) rates may be explained by a shift in how these deaths are classified or reported...
  9. ncbi Electrospray tandem mass spectrometry for analysis of acylcarnitines in dried postmortem blood specimens collected at autopsy from infants with unexplained cause of death
    D H Chace
    Neo Gen Screening, PO Box 219, Bridgeville, PA 15017, USA
    Clin Chem 47:1166-82. 2001
    ..inherited metabolic disorders may remain undiagnosed after postmortem examination and may be classified as sudden infant death syndrome...
  10. ncbi [Epidemiology of 25 years of crib death (sudden infant death syndrome) in the Netherlands; incidence of crib death and prevalence of risk factors in 1980-2004]
    G A de Jonge
    Centraal Bureau voor de Statistiek, Voorburg
    Ned Tijdschr Geneeskd 149:1273-8. 2005
    To describe the prevalence of risk factors and the incidence of cot death (sudden infant death syndrome; SIDS) in the Netherlands during the last 25 years.
  11. ncbi Apparent life-threatening events in presumably healthy newborns during early skin-to-skin contact
    Virginie Andres
    Neonatal Intensive Care Unit, La Conception University Hospital, Marseille, France
    Pediatrics 127:e1073-6. 2011
    ..Although many ALTEs are apparently caused by obstruction, we suggest that a standardized investigational workup be performed after an ALTE...
  12. ncbi Sudden unexpected infant death in Auckland: a retrospective case review
    B Lynne Hutchison
    Department of Paediatrics, The University of Auckland, Auckland, New Zealand
    Acta Paediatr 100:1108-12. 2011
    ..To review autopsy reports of all SUDI deaths in the Auckland region, New Zealand, from October 2000 to December 2009...
  13. ncbi Autonomic responses to sighs in healthy infants and in victims of sudden infant death
    Patricia Franco
    Pediatric Sleep Unit, Hopital Erasme, Brussels, Belgium
    Sleep Med 4:569-77. 2003
    ..Sigh may be followed by a central apnea. As impairment of autonomic control was postulated in future SIDS victims, we hypothesized that their autonomic responses to sighs were different from those of healthy control infants...
  14. ncbi Who is blaming the baby?
    C Peters
    Simpson Centre for Reproductive Health, Royal Infirmary of Edinburgh, Edinburgh, UK
    Arch Dis Child Fetal Neonatal Ed 94:F377-8. 2009
    ..It is postulated that some infants with an underlying vulnerability may maladapt to extrauterine life following an hypoxic stressor possibly caused by positional airway obstruction...
  15. ncbi Sudden Infant Death Syndrome (SIDS): a study of cardiac conduction system
    L Matturri
    Institute of Pathology, University of Milan, Milan, Italy
    Cardiovasc Pathol 9:137-45. 2000
    The theory that Sudden Infant Death Syndrome (SIDS) may be related to lethal cardiac arrhythmias or heart block due to structural abnormalities of the conduction system is attractive and still of particular interest...
  16. ncbi Infection and sudden unexpected death in infancy: a systematic retrospective case review
    M A Weber
    Department of Paediatric Pathology, Great Ormond Street Hospital for Children and the Institute of Child Health, University College London, London, UK
    Lancet 371:1848-53. 2008
    ..The cause and mechanism of most cases of sudden unexpected death in infancy (SUDI) remain unknown, despite specialist autopsy examination. We reviewed autopsy results to determine whether infection was a cause of SUDI...
  17. ncbi Unexpected collapse in apparently healthy newborns--a prospective national study of a missing cohort of neonatal deaths and near-death events
    Julie Clare Becher
    Department of Neonatology, Simpson Centre for Reproductive Health, Royal Infirmary of Edinburgh, Little France Crescent, Edinburgh, UK
    Arch Dis Child Fetal Neonatal Ed 97:F30-4. 2012
    ..The authors undertook a prospective study to ascertain the population incidence of SUPC in the UK...
  18. ncbi Breastfeeding and reduced risk of sudden infant death syndrome: a meta-analysis
    Fern R Hauck
    Department of Family Medicine, University of Virginia School of Medicine, PO Box 800729, Charlottesville, VA 22908, USA
    Pediatrics 128:103-10. 2011
    Benefits of breastfeeding include lower risk of postneonatal mortality. However, it is unclear whether breastfeeding specifically lowers sudden infant death syndrome (SIDS) risk, because study results have been conflicting.
  19. ncbi Possible pathomechanisms of sudden infant death syndrome: key role of chronic hypoxia, infection/inflammation states, cytokine irregularities, and metabolic trauma in genetically predisposed infants
    Joseph Prandota
    Faculty of Medicine and Dentistry, and Department of Social Pediatrics, Faculty of Public Health, University Medical School, Wroclaw, Poland
    Am J Ther 11:517-46. 2004
    ..inflammation states, biochemical disorders, and genetic abnormalities are the most likely trigger of sudden infant death syndrome (SIDS)...
  20. ncbi Sudden unexpected neonatal death in the first week of life: autopsy findings from a specialist centre
    Martin A Weber
    Department of Paediatric Pathology, Great Ormond Street Hospital for Children, London, UK
    J Matern Fetal Neonatal Med 22:398-404. 2009
    ..The aim of this study was to review SUEND autopsies performed in a single specialist centre over a 10-year period, (1996-2005)...
  21. ncbi Sudden deaths and severe apparent life-threatening events in term infants within 24 hours of birth
    Anette Poets
    Department of Neonatology, Tuebingen University Hospital, Calwerstr 7, 72076 Tuebingen, Germany
    Pediatrics 127:e869-73. 2011
    ..To determine the incidence of and possible risk factors for unexpected sudden infant deaths (SID) and severe apparent life-threatening events (S-ALTE) that occurred within 24 hours of birth. This was a monthly epidemiologic survey...
  22. ncbi Sudden Infant Death Syndrome (SIDS) risk reduction and infant sleep location - moving the discussion forward
    Helen L Ball
    Parent Infant Sleep Lab, Department of Anthropology and Wolfson Research Institute, Durham University, Dawson Building, South Road, Durham DH1 3LE, UK
    Soc Sci Med 79:84-91. 2013
    ..We present examples of how more detailed research and culturally-embedded interventions could reorient discussion around infant sleep location...
  23. ncbi Maternal smoking and alcohol consumption during pregnancy as risk factors for sudden infant death
    M McDonnell-Naughton
    Department of Nursing and Health Science, Athlone Institute of Technology, Co Westmeath
    Ir Med J 105:105-8. 2012
    ..The adjusted odds ratio for those consuming alcohol in all three trimesters was 3.59 (CI:1.40-9.20). Both of these risk factors are modifiable and need to be incorporated into antenatal education from a SIDS point of view...
  24. pmc A mouse model to study the link between hypoxia, long QT interval and sudden infant death syndrome
    Marianne T Neary
    Developmental Biology, MRC National Institute for Medical Research, London, NW7 1AA, UK
    Dis Model Mech 6:503-7. 2013
    The pathology of sudden infant death syndrome (SIDS) is poorly understood. Many risk factors, including hypoxia, have been identified...
  25. ncbi Diurnal temperature range as a novel risk factor for sudden infant death
    Chen Chu
    Cardiovascular Center, Children s Hospital of Fudan University, Shanghai 201102, China
    Biomed Environ Sci 24:518-22. 2011
    To assess the relationship between diurnal temperature range (DTR) and sudden infant death (SID) between 2001 and 2004 in Shanghai, China.
  26. pmc An 8 year study of risk factors for SIDS: bed-sharing versus non-bed-sharing
    C McGarvey
    National Sudden Infant Death Register, George s Hall, The Children s University Hospital, Temple St, Dublin 1, Ireland
    Arch Dis Child 91:318-23. 2006
    It is unclear if it is safe for babies to bed share with adults. In Ireland 49% of sudden infant death syndrome (SIDS) cases occur when the infant is bed-sharing with an adult.
  27. ncbi Serotonin transporter gene variation is a risk factor for sudden infant death syndrome in the Japanese population
    N Narita
    Department of Pediatrics, Dokkyo University, School of Medicine, Koshigaya Hospital, Saitama, Japan
    Pediatrics 107:690-2. 2001
    ..Therefore, we aimed to identify the possibility that specific allele variants of the 5-HTT gene can be found as a genetic background for sudden infant death syndrome (SIDS).
  28. pmc Lack of association of the serotonin transporter polymorphism with the sudden infant death syndrome in the San Diego Dataset
    David S Paterson
    Department of Pathology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Res 68:409-13. 2010
    ..respiratory and autonomic function is postulated to underlie the pathogenesis of the majority of sudden infant death syndrome (SIDS) cases...
  29. pmc Hazardous cosleeping environments and risk factors amenable to change: case-control study of SIDS in south west England
    Peter S Blair
    Department of Community Based Medicine, University of Bristol
    BMJ 339:b3666. 2009
    To investigate the factors associated with sudden infant death syndrome (SIDS) from birth to age 2 years, whether recent advice has been followed, whether any new risk factors have emerged, and the specific circumstances in which SIDS ..
  30. pmc Loss-of-function mutations in the KCNJ8-encoded Kir6.1 K(ATP) channel and sudden infant death syndrome
    David J Tester
    Department of Medicine, Division of Cardiovascular Diseases, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN 55905, USA
    Circ Cardiovasc Genet 4:510-5. 2011
    Approximately 10% of sudden infant death syndrome (SIDS) may stem from cardiac channelopathies. The KCNJ8-encoded Kir6...
  31. pmc A perspective on SIDS pathogenesis. the hypotheses: plausibility and evidence
    Paul N Goldwater
    Microbiology and Infectious Diseases, SA Pathology at the Women s and Children s Hospital
    BMC Med 9:64. 2011
    Several theories of the underlying mechanisms of Sudden Infant Death Syndrome (SIDS) have been proposed...
  32. ncbi Factors associated with the transition to nonprone sleep positions of infants in the United States: the National Infant Sleep Position Study
    M Willinger
    Pregnancy and Perinatology Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 7510, USA
    JAMA 280:329-35. 1998
    Studies have demonstrated strong associations between the prone sleep position (on the stomach) and sudden infant death syndrome (SIDS)...
  33. ncbi Clinical correlates, natural history and outcome of neonatal apnoea
    Terry M Baird
    Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH 44106, USA
    Semin Neonatol 9:205-11. 2004
    ..Infants who have apnoea in the newborn period are thought not to be at higher risk for sudden infant death syndrome (SIDS)...
  34. ncbi The frequency of molecular detection of virulence genes encoding cytolysin A, high-pathogenicity island and cytolethal distending toxin of Escherichia coli in cases of sudden infant death syndrome does not differ from that in other infant deaths and healt
    Amanda R Highet
    Department of Microbiology and Infectious Diseases, Women s and Children s Hospital, North Adelaide, South Australia, Australia
    J Med Microbiol 58:285-9. 2009
    Consistent pathological findings in sudden infant death syndrome (SIDS) are seen which display similarities to the pathogenesis of toxaemic shock and/or sepsis...
  35. ncbi Review of risk factors for sudden infant death syndrome
    F M Sullivan
    Division of Pharmacology and Toxicology, United Medical School, University of London, UK
    Paediatr Perinat Epidemiol 15:144-200. 2001
    b>Sudden infant death syndrome (SIDS) accounts for the largest number of deaths during the first year of life in developed countries...
  36. ncbi Intrathoracic petechial hemorrhages in sudden infant death syndrome and other infant deaths: time for re-examination
    Paul N Goldwater
    Microbiology and Infectious Diseases Department, The Women s and Children s Hospital, Discipline of Paediatrics, Children, Youth and Women s Health Service, North Adelaide, South Australia 5006, Australia
    Pediatr Dev Pathol 11:450-5. 2008
    ..pathogenesis of intrathoracic petechial hemorrhages through a retrospective autopsy report review of 174 sudden infant death syndrome (SIDS) cases (2004 definition) and 67 age-matched comparison deaths...
  37. ncbi SIDS: past, present and future
    Edwin A Mitchell
    Department of Paediatrics, University of Auckland, Auckland, New Zealand
    Acta Paediatr 98:1712-9. 2009
    ..This paper describes the position in the 1980s, the contribution of the New Zealand Cot Death Study, what should be recommended and the current research priorities...
  38. pmc Prenatal nicotine-exposure alters fetal autonomic activity and medullary neurotransmitter receptors: implications for sudden infant death syndrome
    Jhodie R Duncan
    Dept of Pathology, Enders 1112 1, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    J Appl Physiol (1985) 107:1579-90. 2009
    During pregnancy, exposure to nicotine and other compounds in cigarette smoke increases the risk of the sudden infant death syndrome (SIDS) two- to fivefold...
  39. ncbi Sudden infant death syndrome: how significant are the cardiac channelopathies?
    David J Tester
    Department of Medicine, Mayo Clinic College of Medicine, United States
    Cardiovasc Res 67:388-96. 2005
    ..This tragedy is compounded when the infant's death is unexpected and unexplained, signed out as sudden infant death syndrome (SIDS)...
  40. pmc Risk factor changes for sudden infant death syndrome after initiation of Back-to-Sleep campaign
    Felicia L Trachtenberg
    New England Research Institutes, Watertown, Massachusetts, USA
    Pediatrics 129:630-8. 2012
    To test the hypothesis that the profile of sudden infant death syndrome (SIDS) changed after the Back-to-Sleep (BTS) campaign initiation, document prevalence and patterns of multiple risks, and determine the age profile of risk factors.
  41. ncbi Guidelines for neuropathologic diagnostics of perinatal unexpected loss and sudden infant death syndrome (SIDS): a technical protocol
    Luigi Matturri
    Institute of Pathology, University of Milan, Via della Commenda, Milan, Italy
    Virchows Arch 452:19-25. 2008
    ..of the growing information on the pathophysiology and clinical aspects of unexpected perinatal loss and sudden infant death syndrome (SIDS), a novel approach to the inherent problems by pathologists has become necessary...
  42. pmc Air pollution and infant death in southern California, 1989-2000
    Beate Ritz
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, PO Box 951772, 650 Charles E Young Dr, Los Angeles, California 90095 1772, USA
    Pediatrics 118:493-502. 2006
    ..We evaluated the influence of outdoor air pollution on infant death in the South Coast Air Basin of California, an area characterized by some of the worst air quality in the United States...
  43. ncbi Why babies should never sleep alone: a review of the co-sleeping controversy in relation to SIDS, bedsharing and breast feeding
    James J McKenna
    University of Notre Dame, Notre Dame, Indiana, IN 46556, USA
    Paediatr Respir Rev 6:134-52. 2005
    ....
  44. pmc Social deprivation and the causes of stillbirth and infant mortality
    Z E Guildea
    Department of Child Health, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Arch Dis Child 84:307-10. 2001
    ..The early neonatal mortality rate was not significantly associated with deprivation. Sudden infant death syndrome showed a 307% (95% CI 197% to 456%) increase in mortality across the range of deprivation...
  45. ncbi Smoking and the sudden infant death syndrome
    E A Mitchell
    Department of Paediatrics, University of Auckland, New Zealand
    Rev Environ Health 21:81-103. 2006
    ..are (a) to critically examine the epidemiologic evidence for a possible association between smoking and the sudden infant death syndrome (SIDS), (b) to review the pathology and postulated physiological mechanism(s) by which smoking ..
  46. doi International trends in sudden infant death syndrome: stabilization of rates requires further action
    Fern R Hauck
    University of Virginia School of Medicine, Department of Family Medicine, PO Box 800729, Charlottesville, VA 22908 0729, USA
    Pediatrics 122:660-6. 2008
  47. ncbi An infectious aetiology of sudden infant death syndrome
    A R Highet
    Department of Microbiology and Infectious Diseases, Children, Youth and Women s Health Service, Women s and Children s Hospital, North Adelaide, SA, Australia
    J Appl Microbiol 105:625-35. 2008
    Due attention has been given to infectious agents and immune responses to infection in sudden infant death syndrome (SIDS)...
  48. ncbi The triple risk hypotheses in sudden infant death syndrome
    Warren G Guntheroth
    Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington 98195 6320, USA
    Pediatrics 110:e64. 2002
    b>Sudden infant death syndrome (SIDS) victims were regarded as normal as a matter of definition (Beckwith 1970) until 1952 when Kinney and colleagues argued for elimination of the clause, "unexpected by history...
  49. ncbi Cardiorespiratory events recorded on home monitors: Comparison of healthy infants with those at increased risk for SIDS
    R Ramanathan
    Department of Pediatrics, Yale Medical School, Box 208064, New Haven, CT 06520-8064, USA
    JAMA 285:2199-207. 2001
    ..monitors designed to identify cardiorespiratory events are frequently used in infants at increased risk for sudden infant death syndrome (SIDS), but the efficacy of such devices for this use is unproven...
  50. pmc Infants bed-sharing with mothers
    M Wailoo
    Department of Child Health, University of Leicester, Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK
    Arch Dis Child 89:1082-3. 2004
  51. ncbi The G protein beta3 subunit 825C allele is associated with sudden infant death due to infection
    Siri Hauge Opdal
    Institute of Forensic Medicine, University of Oslo, Department of Medical Biochemistry, Rikshospitalet University Hospital, Oslo, Norway
    Acta Paediatr 95:1129-32. 2006
    ..The reported association between the Gbeta3s protein and increased immune cell function in humans makes this polymorphism highly interesting both with regard to sudden infant death syndrome (SIDS) and deleterious infectious disease.
  52. ncbi Sudden infant and perinatal unexplained death: are we moving forward yet?
    Giulia Ottaviani
    Dipartimento di Scienze Materno Infantili, Fondazione IRCCS Ospedale Maggiore Policlinico Mangiagalli Regina Elena, Universita degli Studi di Milano, Milan, Italy
    Cardiovasc Pathol 20:302-6. 2011
    ..system and cardiac conducting system dysfunctions have been proposed to be implied in the pathogenesis of sudden infant death syndrome (SIDS)...
  53. ncbi Alveolar septal collapse in the transitional infant lung: a possible common mechanism in sudden unexpected death in infancy
    N J Sebire
    Department of Paediatric Pathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK
    Med Hypotheses 63:485-93. 2004
    ..Many epidemiological risk factors for SUDI could influence such a mechanism, leading to the proposal that Alveolar Septal Collapse in Infancy (ASCI) is a core mechanism via which these factors act...
  54. ncbi Coxsackie B3 myocarditis in 4 cases of suspected sudden infant death syndrome: diagnosis by immunohistochemical and molecular-pathologic investigations
    Reinhard Dettmeyer
    Department of Forensic Medicine, University of Bonn, Bonn, Germany
    Pathol Res Pract 198:689-96. 2002
    ..Their deaths were attributed to SIDS (sudden infant death syndrome)...
  55. pmc Widening social inequalities in risk for sudden infant death syndrome
    Kate E Pickett
    Department of Health Sciences, Seebohm Rowntree Building, Area 3, University of York, Heslington, York, Y010 5DD, England
    Am J Public Health 95:1976-81. 2005
    ..Public Health Service launched the "Back to Sleep" campaign, promoting the supine sleep position to prevent sudden infant death syndrome (SIDS)...
  56. pmc A multivariate "time based" analysis of SIDS risk factors
    T Matthews
    University College Dublin, Dept of Paediatrics, The Children s University Hospital, Temple St, Dublin, Republic of Ireland
    Arch Dis Child 89:267-71. 2004
    To investigate the influence of analytical design on the variability of published results in studies of sudden infant death syndrome (SIDS).
  57. ncbi Sudden, unexpected and unexplained early neonatal deaths in the North of England
    J Y Leow
    Newcastle University, Newcastle upon Tyne, UK
    Arch Dis Child Fetal Neonatal Ed 96:F440-2. 2011
    ..The authors conclude that unexplained ENSUD is even more rare than has been appreciated and its incidence has not been altered by the considerable changes in maternity care over the last 25 years...
  58. ncbi Unexplained stillbirth versus SIDS: common congenital diseases of the autonomic nervous system--pathology and nosology
    Luigi Matturri
    Lino Rossi Research Center for the Study and Prevention of Sudden Perinatal Death and SIDS, Department of Surgical, Reconstructive and Diagnostic Sciences, University of Milan, Milan 20122, Italy
    Early Hum Dev 87:209-15. 2011
    ..To contribute to a more balanced assessment of the morphological substrates underlying unexplained perinatal death and SIDS...
  59. ncbi Sudden infant death syndrome: association with a promoter polymorphism of the serotonin transporter gene
    Debra E Weese-Mayer
    Department of Pediatrics, Rush University, Rush Children s Hospital at Rush Presbyterian St Luke s Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA
    Am J Med Genet A 117:268-74. 2003
    ..raphé obscurus, and other medullary regions is decreased in sudden infant death syndrome (SIDS) cases...
  60. ncbi Infant sleeping position and the risk of sudden infant death syndrome in California, 1997-2000
    De Kun Li
    Division of Research, Kaiser Foundation Research Institute, Kaiser Permanente, Oakland, CA 94612, USA
    Am J Epidemiol 157:446-55. 2003
    To assess the association between infant sleeping position and risk of sudden infant death syndrome (SIDS) in an ethnically diverse US population, the authors conducted a population-based case-control study in 11 counties in California ..
  61. ncbi [Sleeping habits related to sudden infant death syndrome: a population-based study]
    Lorena Teresinha Consalter Geib
    Universidade de Passo Fundo, Rua Tiradentes 400, Apto 601, Passo Fundo, RS 99010 260, Brazil
    Cad Saude Publica 22:415-23. 2006
    This cross-sectional study on sleeping habits with potential risk for sudden infant death syndrome included all live births in Passo Fundo, Rio Grande do Sul, Brazil, in 2003 with data collection from Certificates of Live Birth and ..
  62. ncbi Crib death: further support for the concept of fatal cardiac electrical instability as the final common pathway
    Giulia Ottaviani
    Institute of Pathology, University of Milan, Via della Commenda 19, 20122 Milan, Italy
    Int J Cardiol 92:17-26. 2003
    ....
  63. ncbi Cytomegalovirus-induced pneumonia and myocarditis in three cases of suspected sudden infant death syndrome (SIDS): diagnosis by immunohistochemical techniques and molecularpathologic methods
    Reinhard Dettmeyer
    Department of Forensic Medicine, University of Bonn, Stiftsplatz 12, D 53111 Bonn, Germany
    Forensic Sci Int 174:229-33. 2008
    ..Their deaths were attributed to SIDS (sudden infant death syndrome)...
  64. ncbi Mechanisms of pathogenesis in the Sudden Infant Death Syndrome
    J C Leiter
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, United States
    Respir Physiol Neurobiol 159:127-38. 2007
    The likely processes of the Sudden Infant Death Syndrome (SIDS) were identified many years ago (apnea, failed arousal, failed autoresuscitation, etc.)...
  65. ncbi Bed-sharing in the first four months of life: a risk factor for sudden infant death
    Jan H Ruys
    Leiden University Medical Center, Reviuslaan 38, 2343 JR Oegstgeest, The Netherlands
    Acta Paediatr 96:1399-403. 2007
    To investigate the risk of sudden infant death in the Netherlands during bed-sharing in the first half year of life and the protective effect of breastfeeding on it.
  66. ncbi Parallel incidences of sudden infant death syndrome and infantile hypertrophic pyloric stenosis: a common cause?
    S Persson
    Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    Pediatrics 108:E70. 2001
    ..a correlation between the incidence of infantile hypertrophic pyloric stenosis (IHPS) and the incidence of sudden infant death syndrome (SIDS) during the period 1970 to 1997 and to discuss different causative factors that could be ..
  67. ncbi Identification of Pneumocystis carinii in the lungs of infants dying of sudden infant death syndrome
    D J Morgan
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Pediatr Infect Dis J 20:306-9. 2001
    ..Pneumocystis carinii has been identified in a significant number of infants diagnosed as having died from sudden infant death syndrome (SIDS) in South America and Europe...
  68. ncbi Sleep position and bed-sharing in sudden infant deaths: an examination of autopsy findings
    J R Thogmartin
    Palm Beach County Medical Examiner Office, West Palm Beach, Florida 33406, USA
    J Pediatr 138:212-7. 2001
    ..supine and side sleeping infants were more likely to be classified as a natural disease process other than sudden infant death syndrome (P <.01). Significant autopsy findings that could explain death were found in 47...
  69. ncbi Sudden and unexpected and near death during the early neonatal period: a multicenter study
    Pei Chen Tsao
    Institute of Emergency and Critical Care Medicine and Department of Pediatrics, National Yang Ming University School of Medicine, Taipei, Taiwan, ROC
    J Chin Med Assoc 75:65-9. 2012
    ..To investigate the incidence, clinical presentation and possible etiologies or risk factors of early onset of sudden and unexpected death or near-miss...
  70. ncbi Expression of brain-derived neurotrophic factor and TrkB receptor in the sudden infant death syndrome brainstem
    Samantha Tang
    Department of Paediatrics and Child Health, University of Sydney, NSW 2006, Australia Bosch Institute, The University of Sydney, NSW 2006, Australia
    Respir Physiol Neurobiol 180:25-33. 2012
    ..study compared the expression of BDNF (proBDNF and rhBDNF forms) and its receptor TrkB, in the medulla of sudden infant death syndrome (SIDS) infants and infants who died from known causes (non-SIDS)...
  71. ncbi Sudden infant death syndrome (SIDS): characteristics of deaths since the fall in SIDS in the French region of Languedoc-Roussillon
    C Rouleau
    Department of Pathology, Lapeyronie Hospital, 34295 Montpellier, France
    Arch Dis Child 94:894-6. 2009
    The characteristics of sudden infant death syndrome (SIDS) in the French region of Languedoc-Roussillon from 2003-2008 were examined in a retrospective study of two groups classified as unexplained sudden unexpected death in infancy (..
  72. ncbi Does breastfeeding reduce the risk of sudden infant death syndrome?
    M M Vennemann
    PD, University of Munster, Institute of Legal Medicine, Röntgenstrasse 23, D 48149 Munster, Germany
    Pediatrics 123:e406-10. 2009
    In the last 20 years, the prevention campaigns to reduce the risk of sudden infant death syndrome were very successful. In some countries the advice to breastfeed is included in the campaigns' messages, but in other countries it is not.
  73. ncbi Pneumocystis is not a direct cause of sudden infant death syndrome
    Sergio L Vargas
    Programa de Microbiología Instituto de Ciencias Biomédicas, Facultad de Medicina Universidad de Chile, Santiago, Chile
    Pediatr Infect Dis J 26:81-3. 2007
    We compared the frequency of Pneumocystis in 126 sudden infant death syndrome (SIDS) cases with a control group of 24 infants from the San Diego SIDS/SUDC Research Project who died of accidental or inflicted injuries...
  74. ncbi SIDS-protective infant care practices among Auckland, New Zealand mothers
    Lynne Hutchison
    Department of Paediatrics, The University of Auckland, Auckland
    N Z Med J 119:U2365. 2006
    To survey the knowledge and implementation of sudden infant death syndrome (SIDS)-protective infant care practices in mothers of infants aged less than 4 months.
  75. pmc Sudden unexpected infant deaths: sleep environment and circumstances
    Patricia G Schnitzer
    Patricia G Schnitzer is with the Sinclair School of Nursing, University of Missouri, Columbia Theresa M Covington is with the National Center for Child Death Review, Michigan Public Health Institute, Okemos Heather K Dykstra is with the Michigan Public Health Institute
    Am J Public Health 102:1204-12. 2012
    ..infants who die suddenly and unexpectedly and to examine similarities and differences in risk factors among infants whose deaths are classified as resulting from sudden infant death syndrome (SIDS), suffocation, or undetermined causes.
  76. ncbi Increasing prevalence of smoke-free homes and decreasing rates of sudden infant death syndrome in the United States: an ecological association study
    Ilan Behm
    Center for Global Tobacco Control, Department of Society, Human Development, and Health, Harvard School of Public Health, Boston, MA 02115, USA
    Tob Control 21:6-11. 2012
    This study utilises an ecological design to analyse the relation between concurrent temporal trends in sudden infant death syndrome (SIDS) rates and prevalence of smoke-free households with infants in the USA, controlling for an ..
  77. pmc Size for gestational age at birth: impact on risk for sudden infant death and other causes of death, USA 2002
    Michael H Malloy
    Department of Pediatrics, University of Texas Medical Branch, 301 University Blvd, Galveston, Texas, USA
    Arch Dis Child Fetal Neonatal Ed 92:F473-8. 2007
    Small for gestational age (SGA) infants have been reported to be at higher risk for sudden infant death syndrome (SIDS).
  78. pmc Tragic and sudden death. Potential and proven mechanisms causing sudden infant death syndrome
    Bradley Thach
    Department of Pediatrics, Washington University in St Louis, MO, USA
    EMBO Rep 9:114-8. 2008
  79. ncbi Gliosis in neonatal SUDI cases
    May Chiu
    Medical Student, University of Otago, Wellington, New Zealand
    Acta Paediatr 101:30-3. 2012
    ..To review sudden unexpected infant deaths (SUDI) in the first 28 days of life referred to a Coronial Perinatal Forensic Pathology Service over a 10-year period from 2000 to 2009...
  80. ncbi Influence of environmental factors in higher risk of sudden infant death syndrome linked with parental mental illness
    Roger T Webb
    Centre for Women s Mental Health and Health Methodology Research Group, University of Manchester, Room 2 311, University Place, Oxford Road, Manchester M13 9PL, England
    Arch Gen Psychiatry 67:69-77. 2010
    Since national risk reduction campaigns have been conducted, sudden infant death syndrome (SIDS) has become increasingly concentrated among disadvantaged families, including those affected by mental illness...
  81. ncbi Studying sudden and unexpected infant deaths in a time of changing death certification and investigation practices: evaluating sleep-related risk factors for infant death in New York City
    Lindsay Senter
    Bureau of Maternal, Infant and Reproductive Health, New York City Department of Health and Mental Hygiene, 2 Lafayette Street, New York, NY 10007, USA
    Matern Child Health J 15:242-8. 2011
    ..This will help jurisdictions interpret their infant mortality statistics, which in turn will improve education and prevention efforts...
  82. ncbi Sarcomeric gene mutations in sudden infant death syndrome (SIDS)
    Maria Brion
    Genetics of Cardiovascular and Ophthalmologic Diseases, Hospital University Complex of Santiago CHUS, Santiago de Compostela, Spain
    Forensic Sci Int 219:278-81. 2012
    In developed countries, sudden infant death syndrome (SIDS) represents the most prevalent cause of death in children between 1 month and 1 year of age...
  83. ncbi The metabolic investigation of sudden infant death
    Simon E Olpin
    Department of Clinical Chemistry, Sheffield Children s Hospital, Sheffield S10 2TH, UK
    Ann Clin Biochem 41:282-93. 2004
    ..In particular, inherited disorders of fatty acid oxidation may closely mimic sudden infant death syndrome. Post-mortem investigations offer the final opportunity to establish a diagnosis...
  84. ncbi Infant-parent co-sleeping in an evolutionary perspective: implications for understanding infant sleep development and the sudden infant death syndrome
    J J McKenna
    Pomona College, Claremont, California 91711
    Sleep 16:263-82. 1993
    ..of optimal sleep patterning in infants and confer other benefits, including reducing the risk of the sudden infant death syndrome (SIDS). These postulations by McKenna are considered from different perspectives by the coauthors...
  85. ncbi An audit of the use of definitions of sudden infant death syndrome (SIDS)
    Roger W Byard
    Discipline of Pathology, Level 3, Medical School North, The University of Adelaide, Frome Road, Adelaide 5005, Australia
    J Forensic Leg Med 14:453-5. 2007
    ..Failure to use standard published definitions of SIDS and/or to clearly specify the definition that has been followed may severely hamper the evaluation of SIDS research...
  86. ncbi A serotonin malfunction hypothesis by finding clear mutual relationships between several risk factors and symptoms associated with sudden infant death syndrome
    N Okado
    Neurobiology Laboratory, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8577, Japan
    Med Hypotheses 58:232-6. 2002
    ..variants in the promoter of serotonin transporter (5-HTT) gene have been shown as a novel risk factor for sudden infant death syndrome (SIDS)...
  87. ncbi Sudden infant death syndrome in twins and singletons
    Peter O D Pharoah
    Department of Public Health, University of Liverpool, Liverpool, United Kingdom
    Twin Res Hum Genet 10:644-8. 2007
    ..The aim of this study is to investigate whether zygosity is a risk factor for the sudden infant death syndrome (SIDS)...
  88. ncbi Sudden fetal and infant deaths: shared characteristics and distinctive features
    William P Fifer
    Department Psychiatry, Columbia University, and Psychiatric Institute New York, 10032, USA
    Semin Perinatol 26:89-96. 2002
    Recent evidence suggests sudden infant death syndrome (SIDS) infants have a diminished capacity to respond to autonomic challenges during a vulnerable developmental period...
  89. ncbi Risk factors, diagnosis and prevention of sudden unexpected infant death
    Akihiro Takatsu
    Department of Forensic Medicine, Jikei University School of Medicine, 3 25 8, Nishi Shinbashi, Minato ku, Tokyo 105 8461, Japan
    Leg Med (Tokyo) 9:76-82. 2007
    ..During the sudden infant death syndrome (SIDS) epidemic, many reports described the risk factors of SIDS as well as mechanical suffocation ..
  90. ncbi Sudden infant death syndrome (SIDS) and child care centres (CCC)
    U Kiechl-Kohlendorfer
    Department of Paediatrics, Division of Neonatology, Neuropaediatrics and Metabolic Diseases, Innsbruck Medical University, Innsbruck, Austria
    Acta Paediatr 97:844-5. 2008
    Our aim was to review the risk of sudden infant death syndrome (SIDS) when infants are in child care (CC), to discuss factors potentially responsible for SIDS in this setting and to describe the impact of previous information campaigns ..
  91. ncbi Prenatal to early postnatal nicotine exposure impairs central chemoreception and modifies breathing pattern in mouse neonates: a probable link to sudden infant death syndrome
    Jaime Eugenin
    Laboratory of Neural Systems, Department of Biology, Faculty of Chemistry and Biology, Universidad de Santiago de Chile, Santiago 9160000, Chile
    J Neurosci 28:13907-17. 2008
    Nicotine is a neuroteratogen and is the likely link between maternal cigarette smoking during pregnancy and sudden infant death syndrome (SIDS)...
  92. ncbi Heterozygous nonsense SCN5A mutation W822X explains a simultaneous sudden infant death syndrome
    Emanuela Turillazzi
    Department of Forensic Pathology, University of Foggia, Ospedale Colonnello D Avanzo, Viale degli Aviatori 1, 71100, Foggia, Italy
    Virchows Arch 453:209-16. 2008
    The sudden, unexpected, and unexplained death of both members of a set of healthy twins (simultaneous sudden infant death syndrome (SSIDS)) is defined as a case in which both infants meet the definition of sudden infant death syndrome ..
  93. ncbi Repeat sudden unexpected and unexplained infant deaths: natural or unnatural?
    R G Carpenter
    Medical Statistics Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Lancet 365:29-35. 2005
    ..We aimed to estimate the probability that a second infant death is natural versus unnatural...
  94. ncbi Molecular typing of Pneumocystis jirovecii found in formalin-fixed paraffin-embedded lung tissue sections from sudden infant death victims
    M Chabé
    Ecology of Parasitism, EA 3609 IFR17, Pasteur Institute of Lille, 1 rue du Professeur Calmette BP245, 59019 Lille, France
    Microbiology 150:1167-72. 2004
    ..studies have provided histological evidence of an association between primary Pneumocystis infection and sudden infant death syndrome (SIDS)...
  95. ncbi Unexplained infant and child death: a review of sudden infant death syndrome, sudden unexplained infant death, and child maltreatment fatalities including shaken baby syndrome
    Alice W Newton
    Department of Pediatrics, Harvard Medical School, and the Child Protection Program of Massachusetts General Hospital, Boston, Massachusetts 02115, USA
    Curr Opin Pediatr 18:196-200. 2006
    This review will examine the most recent published literature on Sudden Infant Death, Sudden Unexplained Infant Death, infant and child death due to maltreatment, and Shaken Baby Syndrome.
  96. pmc Sudden infant death syndrome and sleeping position in pre-term and low birth weight infants: an opportunity for targeted intervention
    P S Blair
    Institute of Child Life and Health, Department of Clinical Science, South Bristol, University of Bristol, UK
    Arch Dis Child 91:101-6. 2006
    To determine the combined effects of sudden infant death syndrome (SIDS) risk factors in the sleeping environment for infants who were "small at birth" (pre-term (<37 weeks), low birth weight (<2500 g), or both).
  97. ncbi NHE3 in the human brainstem: implication for the pathogenesis of the sudden infant death syndrome (SIDS)?
    Martin Wiemann
    University of Duisburg Essen, Department of Physiology
    Adv Exp Med Biol 605:508-13. 2008
    ..As an insufficient drive to breath may be a final event causing sudden infant death, we compared the expression of NHE3 mRNA in a collective of children who died from non-natural causes to an ..
  98. ncbi Mother-infant cosleeping, breastfeeding and sudden infant death syndrome: what biological anthropology has discovered about normal infant sleep and pediatric sleep medicine
    James J McKenna
    Department of Anthropology and Mother Baby Behavioral Sleep Laboratory, University of Notre Dame, Notre Dame, IN 46556, USA
    Am J Phys Anthropol . 2007
    ....
  99. ncbi Sudden unexpected infant death and bedsharing: referrals to the Wellington Coroner 1997-2006
    Alistair Escott
    School of Medicine andHealth Sciences, University of Otago, Wellington, PO Box 7343, Wellington, New Zealand
    N Z Med J 122:59-68. 2009
    ..To describe the factors associated with sudden unexpected infant deaths, for which there was no clear medical diagnosis, referred to the Wellington-based coronial paediatric pathology service over the decade from 1997 to 2006...
  100. ncbi Sudden Infant Death Syndrome and the time of death: factors associated with night-time and day-time deaths
    P S Blair
    Institute of Child Life and Health, Department of Clinical Science, South Bristol, University of Bristol, UK
    Int J Epidemiol 35:1563-9. 2006
    To investigate the diurnal occurrence of Sudden Infant Death Syndrome (SIDS) and interaction with established risk factors in the infant sleeping environment.
  101. ncbi Genetics of the sudden infant death syndrome
    Cornelius Courts
    Institute of Forensic Medicine, University of Bonn, Bonn, Germany
    Forensic Sci Int 203:25-33. 2010
    The sudden infant death syndrome (SIDS) is currently defined as "the sudden unexpected death of an infant less than 1 year of age with onset of the fatal episode apparently occurring during sleep, that remains unexplained after a ..

Research Grants69

  1. ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYS
    Patrice G Guyenet; Fiscal Year: 2013
    ..conditions such as obstructive sleep apnea (OSA), the treatment of pain with opiates, central sleep apnea, sudden infant death syndrome (SIDS), and rare diseases such as congenital central hypoventilation syndrome (CCHS)...
  2. Impact of the P479L Variant in CPT1A on Infant Mortality in Alaska
    David M Koeller; Fiscal Year: 2011
    ..Like other disorders of fatty acid oxidation, CPT1A deficiency can lead to sudden infant death. Preliminary evidence indicates that 26% of all Alaska Native infants are homozygous for the c...
  3. Electrochemical tools to measure local cerebral blood flow and metabolism
    ROBERT MARK WIGHTMAN; Fiscal Year: 2013
    ..These actions are of importance because they have been suggested to be involved in migraine headaches and sudden infant death syndrome, and also to contribute to the signals observed in functional magnetic resonance imaging...
  4. Wireless At-Risk Infant Monitoring System
    JASON HOLMSTEDT; Fiscal Year: 2012
    ..g., sudden infant death syndrome)...
  5. Role of Dendritic Ca2+ Transients in Respiratory Rhythm Generation
    Jack L Feldman; Fiscal Year: 2010
    ..central alveolar hypo- ventilation syndrome, hyperventilation syndrome, Rett syndrome, and perhaps sudden infant death syndrome, leads to serious adverse health consequences, even death...
  6. BRAINSTEM MATURATION IN THE SUDDEN INFANT DEATH SYNDROME
    HANNAH CHASE KINNEY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The sudden infant death syndrome (SIDS) is the leading cause of postneonatal infant mortality in the United States today...
  7. EEG Synchrony, perinatal risk and outcome: analysis of CHIME data
    PHILIP GEORGE GRIEVE; Fiscal Year: 2010
    ..These data are from groups with varying degrees of vulnerability to sudden infant death syndrome (SIDS) and include prematurely born infants, infants with apparent life threatening events (ALTE), ..
  8. High Throughput Methods to Measure Disparities in Childhood Exposure to Tobacco
    Sharon E Murphy; Fiscal Year: 2010
    ..birth- weight, asthma induction, asthma exacerbation, increased ear and lower respiratory infections, and sudden infant death syndrome. Notably, SHS exposure and the health effects of SHS vary by race, ethnicity and SES...
  9. Neural Representation of Reach-to-Grasp for Cortical FES Neuroprostheses
    Abidemi Bolu Ajiboye; Fiscal Year: 2012
    ..Advancements towards this end resulting from the proposed work could significantly improve the quality of life and care of Veterans that is expected after one experiences an impairment resulting in severe paralysis. ..
  10. The upper airway and the Sudden Infant Death Syndrome
    Donald Bartlett; Fiscal Year: 2012
    6. Project Summary/Abstract The incidence of the Sudden Infant Death Syndrome (SIDS) has decreased substantially in the United States and elsewhere as a result of educational campaigns favoring the supine posture for sleeping infants...
  11. BRAINSTEM MATURATION IN THE SUDDEN INFANT DEATH SYNDROME
    Hannah C Kinney; Fiscal Year: 2010
    The sudden infant death syndrome (SEDS) is the leading cause of postneonatal infant mortality, with an overall incidence of 0.8/1000 live births. Its cause(s) is unknown...
  12. Developmental defects in serotonin neurons and the response to O2 and CO2
    George B Richerson; Fiscal Year: 2011
    b>Sudden infant death syndrome (SIDS) is the most common cause of post neonatal infant death in the U.S. The mechanisms are unknown, but abnormalities in the serotonin system have been consistently found in autopsy studies...
  13. Structure and Function of Enzymes in Fatty Acid Oxidation
    JUNG JA P KIM; Fiscal Year: 2013
    ..These disorders present sudden infant death syndrome, cause cardiomyopathy, and are the most common cause of skeletal myopathy in older children and ..
  14. Targeted epigenetic therapy of triple-negative breast cancer
    Samuel Waxman; Fiscal Year: 2013
    ..Successful SID decoy development offers other therapeutic options for triple negative breast cancer and also novel drugable targets. ..
  15. Motivational Incentives to Reduce Secondhand Smoke in NICU Infants'Homes
    Angela L Stotts; Fiscal Year: 2013
    ..pulmonary function and contributes to respiratory illness, wheeze, cough, asthma, middle ear disease, and sudden infant death syndrome...
  16. Predictors of Prenatal Care Providers Counseling Women on Tobacco Use/Exposure
    BETH LEONG PINELES; Fiscal Year: 2013
    ..Low birthweight, preterm birth, stillbirth, and sudden infant death syndrome are among the most prominent effects of maternal smoking and secondhand smoke exposure during ..
  17. Nicotine Modulation of Parasympathetic Cardiac Neurons
    David Mendelowitz; Fiscal Year: 2013
    ..However an exaggerated diving reflex has been implicated in sudden infant death syndrome (SIDS). SIDS is the leading cause of death among infants who are 1 month to 1 year old...
  18. RESPIRATORY PATTERN GENERATION STUDIED IN VITRO
    Jack L Feldman; Fiscal Year: 2012
    ..congenital central hypoventilation syndrome, hyperventilation syndrome, Rett syndrome, and perhaps sudden infant death syndrome, leads to serious adverse health consequences, even death...
  19. Aging and Antipsychotic Efficacy - Epigenetic Mechanisms
    Hongxin Dong; Fiscal Year: 2013
    ..By advancing our understanding of the epigenetic mechanisms of drug efficacy, it will be possible to develop new psychotropic treatment strategies that maximize benefits while minimizing side effects. ..
  20. GENETIC ORGANIZATION OF RESPIRATORY CIRCUITS IN MOUSE BRAINSTEM
    Paul Gray; Fiscal Year: 2013
    ..health are directly related to the brainstem networks underlying breathing such as apnea of prematurity and Sudden Infant Death Syndrome in infants or sleep apnea in adults...
  21. IGF::OT::IGF
    Vivian Leung; Fiscal Year: 2013
    ..SCD has been documented at all ages (approximately 10-15% of sudden infant death syndrome cases may be due to ion channelopathies) and may be associated with competitive athletics...
  22. Genetic and Functional Profiles of Serotonergic Neuron Subtypes
    Rachael D Brust; Fiscal Year: 2013
    ..neurotransmission are implicated in numerous disorders from pediatric developmental disorders including the sudden infant death syndrome (SIDS), autism, Rett syndrome, and Prader-Willi syndrome1-6, to adult psychiatric disorders ..
  23. Hybrid atomic force-optical imaging system to investigate prenatal nicotine
    Jeffrey Potts; Fiscal Year: 2009
    ..breathing, diminishes the compensatory respiratory response to hypoxic stress and contributes to sudden infant death syndrome (SIDS)...
  24. Impact of Exercise on Body Composition in Premature Infants: New Approaches
    Dan M Cooper; Fiscal Year: 2013
    ..interventions has been recently demonstrated by the success of the "Back-To-Sleep" campaign in mitigating sudden infant death syndrome...
  25. Coordination of orofacial and respiratory movements
    Detlef H Heck; Fiscal Year: 2012
    ..in coordinating orofacial and respiratory movements are implicated in human health conditions such as sudden infant death syndrome (SIDS), swallowing dysfunction (dysphagia) and speech disorders (dysarthria)...
  26. Sleep, Arousal, and Spontaneous Movements in Opioid Exposed Infants
    Marie J Hayes; Fiscal Year: 2010
    ..Our preliminary studies in apneic and alcohol-exposed infants at high risk for Sudden Infant Death Syndrome (SIDS) revealed reduced vigor in SM burst duration compared to normative samples...
  27. Molecular Genetic Tools for Parasitic Helminths
    Edward J Pearce; Fiscal Year: 2013
    ....
  28. Effect of Prenatal Nicotinic Exposure on Control of Hypoxic Ventilatory Response
    Fadi Xu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Sudden infant death syndrome (SIDS) is a leading cause of infant mortality. Cigarette smoke (nicotinic exposure) is the key risk factor and hypoxemia is an acute precursor for SIDS...
  29. The Ventral Medulla and the Sudden Infant Death Syndrome
    HANNAH CHASE KINNEY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The sudden infant death syndrome (SIDS) is the sudden death of an infant that remains unexplained after a complete review of the history, autopsy, and death scene investigation;it is the leading ..
  30. Molecular mechanisms of central chemoreception in breathing
    Marco Martina; Fiscal Year: 2013
    ..central hypoventilation syndrome, chronic obstructive pulmonary disease, as well as sleep apnea and sudden infant death syndrome (SIDS)...
  31. MECHANISM OF CARDIORESPIRATORY RHYTHM IN NEONATES
    David Mendelowitz; Fiscal Year: 2013
    ..However an exaggerated diving reflex has been implicated in sudden infant death syndrome (SIDS)...
  32. Infant Sleep Environment Monitoring System (SEMS) for SIDS
    ROBERT A LIEBERMAN; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Many cases of Sudden Infant Death Syndrome (SIDS) could be avoided if the known sleep situations linked to SIDS could be detected and corrected way early before suffocation and/or apnea occurs...
  33. Mechanisms of respiratory long-term facilitation
    Gordon S Mitchell; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Some ventilatory control disorders such as sudden infant death syndrome (SIDS) or respiratory insufficiency in patients with cervical spinal injury or neurodegenerative ..
  34. ETHICAL & SOCIAL IMPLICATIONS OF GENETIC TESTING IN THE CASE OF UNEXPECTED DEATHS
    Siobhan M Dolan; Fiscal Year: 2010
    ..this project are: 1) To evaluate and systematize ethical and social issues associated with investigation of sudden infant death syndrome (SIDS) and sudden unexplained death syndrome (SUDS) that reveals a molecular cardiogenetic cause ..
  35. TripleTOF 5600 Hybrid Mass Spectrometer
    Hanno Steen; Fiscal Year: 2012
    ..pain, Ureteropelvic junction (UPJ) obstruction and pancreatitis, understanding the pathophysiology of Sudden Infant Death Syndrome (SIDS) and Spinal Muscular Atrophy (SMA), the identification of cytokines and receptors on sensory ..
  36. Generation of Respiratory Rhythm
    Jack L Feldman; Fiscal Year: 2013
    ..congenital central hypoventilation syndrome, hyperventilation syndrome, Rett syndrome, and perhaps sudden infant death syndrome, leads to serious adverse health consequences, even death...
  37. Functional dissection of medullary respiratory microcircuits
    Jack L Feldman; Fiscal Year: 2013
    ..congenital central hypoventilation syndrome, hyperventilation syndrome, Rett syndrome, and perhaps sudden infant death syndrome, leads to serious adverse health consequences, even death...
  38. Novel Methods to Reduce Children's Secondhand Smoke Exposure
    THEODORE LEE WAGENER; Fiscal Year: 2013
    ..S. exposed to secondhand smoke. SHSe decreases lung growth and increases the incidence of sudden infant death, respiratory illness, middle-ear disease, and impaired pulmonary function...
  39. Screening for Jervell and Lange-Nielsen Syndrome
    Ruey Kang R Chang; Fiscal Year: 2010
    ..Sudden cardiac death of infants with undiagnosed JLNS is often reported as sudden infant death syndrome (SIDS)...
  40. Cardiac Channel Mutations in SIDS
    MICHAEL JOHN ACKERMAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): With over 2000 deaths each year in the United States, sudden infant death syndrome (SIDS) remains a leading cause of death in infants under 1 year of age...
  41. Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirgh (PASS) Network
    Kimberly A Dukes; Fiscal Year: 2013
    ....
  42. Improving the Self-Efficacy of African American Parents in Infant Supine Sleep
    Kathryn L Moseley; Fiscal Year: 2013
    ..African American infants also die of Sudden Infant Death Syndrome (SIDS) at rates 2-3 times greater than non-Hispanic White infants...
  43. National Estimates for Inpatient Care, Outcomes &Hospital Effect among Hispanics
    Amresh D Hanchate; Fiscal Year: 2013
    ....
  44. Molecular Genetic Analysis of Extracellular RNAs in C. elegans
    CRAIG PATRICK HUNTER; Fiscal Year: 2012
    ..Understanding how dsRNA crosses cell membranes to trigger RNAi will lead to improvements in targeting and delivery efficiency, and will limit potential deleterious side effects of this exciting therapeutic strategy. ..
  45. Cigarette Smoke Induced Injury in Alveolar Cells in Model Systems
    Charles A Downs; Fiscal Year: 2010
    ..to cigarette smoke results in small for gestational age infants and correlates with increased risk for sudden infant death syndrome and asthma...
  46. Regulation of Systemic RNA Interference in the Nematode C. elegans
    JENNIFER SUNG WHANGBO; Fiscal Year: 2013
    ..Execution of these aims will elucidate fundamental mechanisms underlying the import and export of RNA-mediated silencing signals between cells and tissues. ..
  47. Impact of Heath Information Technology on Delivery and Quality of Patient Care
    AMANDA JANE HESSELS; Fiscal Year: 2012
    ..This will impact public health by generating knowledge that may be used to direct valuable resources that will have the greatest positive effect for hospitalized patients. ..
  48. Study of Attitudes and Factors Affecting Infant Care
    Michael J Corwin; Fiscal Year: 2013
    ..Pediatrics'and the Public Health Service's "Back to Sleep" recommendations to reduce the risk of Sudden Infant Death Syndrome (SIDS), and to expand on current studies with a new study that examines in greater depth the ..
  49. The Role of the Transient Outward Current in Genetically Elusive Sudden Death
    John R Giudicessi; Fiscal Year: 2013
    ..autopsy negative sudden death, including 35% of Sudden Unexplained Death Syndrome (SUDS) and 10% of Sudden Infant Death Syndrome (SIDS) cases...
  50. Prenatal ethanol exposure, arousal and the Sudden Infant Death Syndrome (SIDS)
    Robert A Darnall; Fiscal Year: 2013
    ..first trimester of pregnancy, especially those that binge drink, are 6-8 times more likely to die from the Sudden Infant death Syndrome (SIDS), the leading cause post-neonatal infant death...
  51. Neonatal apnea: Online risk score from new analyses of bedside monitor waveforms
    JOSEPH RANDALL contact MOORMAN; Fiscal Year: 2010
    ..to understand its natural history, its therapy, and its relationship to the major public health problem of sudden infant death syndrome, or SIDS...
  52. CSF and the central chemical control of breathing.
    Eugene Edward Nattie; Fiscal Year: 2013
    ..Abnormal central chemoreception is a key defect in the congenital central hypoventilation syndrome and is hypothesized to play a role in the Sudden Infant Death Syndrome.
  53. Retrotrapezoid nucleus and central chemoreception
    Patrice G Guyenet; Fiscal Year: 2013
    ..for congenital central hypoventilation syndrome (CCHS), central and obstructive sleep apnea (OSA), sudden infant death syndrome (SIDS) and the treatment of pain with opiates...
  54. Role of Central 5-HT Transmission in Respiratory Arrest Induced by Seizures
    Huajun Feng; Fiscal Year: 2013
    ..Third, deficits of 5-HT neurotransmission in medulla play a causative role in sudden infant death syndrome, a disorder thought to share similar pathophysiology with SUDEP...
  55. CHD1, Chromatin Dynamics, and Salivary Gland Differentiation
    JOSEPH ADAM HALL; Fiscal Year: 2010
    ..Also, novel therapeutic targets aimed at re-activation of SLG functionality could be identified. ..
  56. Contribution of ASIC channels to intrinsic chemosensitivity of NTS neurons
    Rafiq Huda; Fiscal Year: 2013
    ..in severe morbidity and is implicated in disorders such as congenital central hypoventilation syndrome and sudden infant death syndrome. Yet, the exact molecular mechanisms underlying chemosensitivity have remained largely elusive...
  57. Neonatal Long QT Syndrome and Sudden Infant Death
    Alfred L George; Fiscal Year: 2013
    ....
  58. Brainstem GABAergic Neuron Development and Function
    Russell S Ray; Fiscal Year: 2012
    ..that associated with many common and debilitating, even life-threatening disorders, such as the respiratory abnormalities associated with infant prematurity, with Retts syndrome, Joubert syndrome, and sudden infant death syndrome,
  59. HYPOXIC EFFECTS ON MAMMALIAN RESPIRATORY NEURAL NETWORK
    JAN M RAMIREZ; Fiscal Year: 2010
    b>Sudden infant death syndrome (SIDS) remains the leading cause of postnatal infant mortality in the USA...
  60. Accuracy of Self-Reported Prenatal Smoking in Child Cancer Epidemiology Studies
    Beth A Mueller; Fiscal Year: 2010
    ..This information may help improve studies of childhood cancer and other outcomes such as malformations and Sudden Infant Death Syndrome.
  61. TRPV1 Function at Laryngeal Labeled NTS Neurons
    Mackenzie E Hofmann; Fiscal Year: 2013
    ..DESCRIPTION (provided by applicant): The laryngeal chemoreflex (LCR) is believed to play an integral role in Sudden Infant Death Syndrome (SIDS)...
  62. Dissecting the preB?tzinger complex neural network using holographic photolysis
    Jason Worrell; Fiscal Year: 2013
    ..such as sleep apnea, Rett syndrome, central congenital hypoventilation syndrome (CCHS) and possibly sudden infant death syndrome (SIDS)...
  63. STRUCTURAL STUDIES OF SUPERANTIGENS
    Douglas Ohlendorf; Fiscal Year: 1999
    ..food poisoning, toxic shock syndrome, scarlet and rheumatic fever, arthritis, multiple sclerosis, diabetes, sudden infant death syndrome, Kawasaki syndrome (a leading cause of acquired heart defects), and MDS...
  64. ADENOSINE RECEPTORS AND THE PATHOPHYSIOLOGY OF SIDS
    H Zielke; Fiscal Year: 1990
    Abnormal respiratory control has been cited as a possible cause of death of infants dying from the Sudden Infant Death Syndrome (SIDS)...
  65. Identification of Factors Influencing Climbing Fiber Neuron Fate in the Dorsal Hi
    REBECCA LANDSBERG; Fiscal Year: 2009
    ..documented in association with a number of inherited ataxic syndromes, autism, fetal alcohol syndrome, and sudden infant death syndrome (SIDS), the leading cause of infant mortality in the United States...
  66. PROFILING THE NEEDS OF DYING CHILDREN
    JOHN FEUDTNER; Fiscal Year: 2004
    ..As deaths due to injury, prematurity, and sudden infant death syndrome are prevented, the remaining deaths may be increasingly associated with chronic conditions...
  67. NEUROCHEMICAL CONTROL OF RESPIRATION IN SIDS
    Laurence Becker; Fiscal Year: 1991
    b>Sudden infant death syndrome (SIDS) is a leading cause of death under one year of age. Inspite of numerous investigations, the etiology and pathogenesis of SIDS remains unknown...
  68. Mu Opioid Receptor Regulation in Neonatal Brainstem
    GEORGE OLSEN; Fiscal Year: 2006
    ..These neonates exhibit withdrawal hyperventilation and an increased incidence of sudden infant death syndrome (SIDS)...
  69. ESOPHAGO-LARYNGEAL ADDUCTOR REFLEX
    Nancy Bauman; Fiscal Year: 2000
    ..that bears important similarities with the age predisposition of apparent life-threatening events, and sudden infant death syndrome...