death

Summary

Summary: Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.

Top Publications

  1. pmc Factors influencing death at home in terminally ill patients with cancer: systematic review
    Barbara Gomes
    The Cicely Saunders Foundation Department of Palliative Care, Policy, and Rehabilitation, King s College London, London SE5 9RJ
    BMJ 332:515-21. 2006
  2. doi Cardiovascular death and nonfatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting are predicted by residual platelet reactivity to ADP detected by a point-of-care assay: a 12-month follow-up
    Rossella Marcucci
    Department of Medical and Surgical Critical Care and Center for Study at Molecular and Clinical Level of Chronic, Degenerative and Neoplastic Diseases to Develop Novel Therapies, University of Florence, Florence, Italy
    Circulation 119:237-42. 2009
  3. ncbi Hemolytic uremic syndrome and death in persons with Escherichia coli O157:H7 infection, foodborne diseases active surveillance network sites, 2000-2006
    L Hannah Gould
    Enteric Diseases Epidemiology Branch, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Infect Dis 49:1480-5. 2009
  4. pmc Place of death: correlations with quality of life of patients with cancer and predictors of bereaved caregivers' mental health
    Alexi A Wright
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Clin Oncol 28:4457-64. 2010
  5. doi Reversal of the British trends in place of death: time series analysis 2004-2010
    Barbara Gomes
    King s College London, Cicely Saunders Institute, Department of Palliative Care, Policy and Rehabilitation, London, UK
    Palliat Med 26:102-7. 2012
  6. pmc Study of recent and future trends in place of death in Belgium using death certificate data: a shift from hospitals to care homes
    Dirk Houttekier
    Vrije Universiteit Brussel, End of Life Care Research Group Ghent University and Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
    BMC Public Health 11:228. 2011
  7. doi Plasma asymmetric dimethylarginine predicts death and major adverse cardiovascular events in individuals referred for coronary angiography
    Tse Min Lu
    Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Int J Cardiol 153:135-40. 2011
  8. pmc Aortic arch plaques and risk of recurrent stroke and death
    Marco R Di Tullio
    Division of Cardiology, Department of Medicine, Columbia University, College of Physicians and Surgeons, 630 W 168th St, New York, NY 10032, USA
    Circulation 119:2376-82. 2009
  9. ncbi Irresistible bouquet of death--how are burying beetles (Coleoptera: Silphidae: Nicrophorus) attracted by carcasses
    B Kalinová
    Infochemicals Group, Institute of Organic Chemistry and Biochemistry v v i, Academy of Sciences of the Czech Republic, Flemingovo nam 2, 166 10, Prague 6, Czech Republic
    Naturwissenschaften 96:889-99. 2009
  10. doi Death toll exceeded 70,000 in Europe during the summer of 2003
    Jean Marie Robine
    INSERM, Demographie et Sante, CRLC, Centre Val d Aurelle, Parc Euromedecine, 34298 Montpellier Cedex 5, France
    C R Biol 331:171-8. 2008

Detail Information

Publications305 found, 100 shown here

  1. pmc Factors influencing death at home in terminally ill patients with cancer: systematic review
    Barbara Gomes
    The Cicely Saunders Foundation Department of Palliative Care, Policy, and Rehabilitation, King s College London, London SE5 9RJ
    BMJ 332:515-21. 2006
    To determine the relative influence of different factors on place of death in patients with cancer.
  2. doi Cardiovascular death and nonfatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting are predicted by residual platelet reactivity to ADP detected by a point-of-care assay: a 12-month follow-up
    Rossella Marcucci
    Department of Medical and Surgical Critical Care and Center for Study at Molecular and Clinical Level of Chronic, Degenerative and Neoplastic Diseases to Develop Novel Therapies, University of Florence, Florence, Italy
    Circulation 119:237-42. 2009
    ....
  3. ncbi Hemolytic uremic syndrome and death in persons with Escherichia coli O157:H7 infection, foodborne diseases active surveillance network sites, 2000-2006
    L Hannah Gould
    Enteric Diseases Epidemiology Branch, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Infect Dis 49:1480-5. 2009
    ..We evaluated the age-specific rate of HUS and death among persons with STEC O157 infection and the risk factors associated with developing HUS.
  4. pmc Place of death: correlations with quality of life of patients with cancer and predictors of bereaved caregivers' mental health
    Alexi A Wright
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Clin Oncol 28:4457-64. 2010
    To determine whether the place of death for patients with cancer is associated with patients' quality of life (QoL) at the end of life (EOL) and psychiatric disorders in bereaved caregivers.
  5. doi Reversal of the British trends in place of death: time series analysis 2004-2010
    Barbara Gomes
    King s College London, Cicely Saunders Institute, Department of Palliative Care, Policy and Rehabilitation, London, UK
    Palliat Med 26:102-7. 2012
    ..Secular trends towards an institutionalised dying have been reported in Britain and other developed world regions...
  6. pmc Study of recent and future trends in place of death in Belgium using death certificate data: a shift from hospitals to care homes
    Dirk Houttekier
    Vrije Universiteit Brussel, End of Life Care Research Group Ghent University and Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
    BMC Public Health 11:228. 2011
    Since most patients prefer out-of-hospital death, place of death can be considered an indicator of end-of-life care quality...
  7. doi Plasma asymmetric dimethylarginine predicts death and major adverse cardiovascular events in individuals referred for coronary angiography
    Tse Min Lu
    Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Int J Cardiol 153:135-40. 2011
    ..We assessed the prognostic value of plasma ADMA levels in 997 consecutive individuals referred for coronary angiography from July 2006 to June 2009...
  8. pmc Aortic arch plaques and risk of recurrent stroke and death
    Marco R Di Tullio
    Division of Cardiology, Department of Medicine, Columbia University, College of Physicians and Surgeons, 630 W 168th St, New York, NY 10032, USA
    Circulation 119:2376-82. 2009
    ..Aortic arch plaques are a risk factor for ischemic stroke. Although the stroke mechanism is conceivably thromboembolic, no randomized studies have evaluated the efficacy of antithrombotic therapies in preventing recurrent events...
  9. ncbi Irresistible bouquet of death--how are burying beetles (Coleoptera: Silphidae: Nicrophorus) attracted by carcasses
    B Kalinová
    Infochemicals Group, Institute of Organic Chemistry and Biochemistry v v i, Academy of Sciences of the Czech Republic, Flemingovo nam 2, 166 10, Prague 6, Czech Republic
    Naturwissenschaften 96:889-99. 2009
    ..Chemical analysis showed that immediately after death, emitted volatiles did not differ from those emitted by a living organism...
  10. doi Death toll exceeded 70,000 in Europe during the summer of 2003
    Jean Marie Robine
    INSERM, Demographie et Sante, CRLC, Centre Val d Aurelle, Parc Euromedecine, 34298 Montpellier Cedex 5, France
    C R Biol 331:171-8. 2008
    ..Centralizing the count of daily deaths on an operational geographical scale constitutes a priority for Public Health in Europe...
  11. doi Place of death in metropolitan regions: metropolitan versus non-metropolitan variation in place of death in Belgium, The Netherlands and England
    Dirk Houttekier
    End of Life Care Research Group, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
    Health Place 16:132-9. 2010
    Place of death is an important societal indicator of end-of-life quality for the terminally ill...
  12. ncbi A palliative-care intervention and death at home: a cluster randomised trial
    M S Jordhøy
    Unit of Applied Clinical Research, Norwegian University of Science and Technology, Kreftbygget, University Hospital of Trondheim
    Lancet 356:888-93. 2000
    ..We did a cluster randomised trial to assess the intervention's effectiveness compared with conventional care..
  13. ncbi The transformation of utilities for health states worse than death: consequences for the estimation of EQ-5D value sets
    Leida M Lamers
    Institute for Medical Technology Assessment Department of Health Policy and Management, Erasmus University Medical Center Rotterdam, The Netherlands
    Med Care 45:238-44. 2007
    Utilities for health are measured on an interval scale, where 1 refers to full health and 0 refers to death. No theoretical lower boundary on the utilities for states worse than death exists...
  14. ncbi Pediatric heart transplantation after declaration of cardiocirculatory death
    Mark M Boucek
    Department of Pediatrics, Joe DiMaggio Children s Hospital, Hollywood, FL 33021, USA
    N Engl J Med 359:709-14. 2008
    ..The mean age of donors was 3.7 days, and the mean time to death after withdrawal from life support was 18.3 minutes...
  15. doi Death or hospitalization of patients on chronic hemodialysis is associated with a physician-based diagnosis of depression
    S Susan Hedayati
    Division of Nephrology, Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Kidney Int 74:930-6. 2008
    ..Using time to event (death or hospitalization) models of analysis the hazard ratios were 2.11 and 2...
  16. doi There is nothing paranormal about near-death experiences: how neuroscience can explain seeing bright lights, meeting the dead, or being convinced you are one of them
    Dean Mobbs
    Medical Research Council, Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, CB2 7EF, UK
    Trends Cogn Sci 15:447-9. 2011
    Approximately 3% of Americans declare to have had a near-death experience...
  17. ncbi Stroke in parents who lost a child: a nationwide follow-up study in Denmark
    Jiong Li
    Danish Epidemiology Science Centre, Department of Epidemiology and Social Medicine, University of Aarhus, Aarhus, Denmark
    Neuroepidemiology 22:211-6. 2003
    ..We therefore examined whether or not one of the most extreme psychological stressors, the death of a child, was associated with the risk of stroke in a nationwide population-based follow-up study...
  18. ncbi "Death" and the valuation of health-related quality of life
    S Macran
    Center for Health Economics, University of York, Helsington, York, United Kingdom
    Med Care 39:217-27. 2001
    ....
  19. doi Review: the quality of dying and death: a systematic review of measures
    Sarah Hales
    Psychosocial Oncology and Palliative Care, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada
    Palliat Med 24:127-44. 2010
    ..To determine whether modern medicine is facilitating 'good' deaths, appropriate measures of the quality of dying and death must be developed and utilized...
  20. doi Factors influencing place of death in Germany
    Luis Carlos Escobar Pinzón
    Institute of Occupational, Social and Environmental Medicine, University Medical Center of Johannes Gutenberg University of Mainz, Mainz, Germany
    J Pain Symptom Manage 41:893-903. 2011
    Knowledge about factors influencing the place of death may be very useful for the planning of public health strategies to improve the situation of terminally ill patients.
  21. pmc Discordance between living and death assemblages as evidence for anthropogenic ecological change
    Susan M Kidwell
    Department of Geophysical Sciences, University of Chicago, 5734 South Ellis Avenue, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 104:17701-6. 2007
    Mismatches between the composition of a time-averaged death assemblage (dead remains sieved from the upper mixed-zone of the sedimentary column) and the local living community are typically attributed to natural postmortem processes...
  22. doi Current situation of donation after circulatory death in European countries
    Beatriz Dominguez-Gil
    Organizacion Nacional de Trasplantes, Madrid, Spain
    Transpl Int 24:676-86. 2011
    The aim of the present study was to describe the current situation of donation after circulatory death (DCD) in the Council of Europe, through a dedicated survey...
  23. pmc Protein kinase Cepsilon makes the life and death decision
    Alakananda Basu
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Cell Signal 19:1633-42. 2007
    ..is caused by dysregulation in cellular signaling systems that control cell proliferation, differentiation and cell death. Protein kinase C (PKC), a family of serine/threonine kinases, plays an important role in the growth factor signal ..
  24. ncbi Predictors of place of death for seniors in Ontario: a population-based cohort analysis
    Sanober S Motiwala
    Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada
    Can J Aging 25:363-71. 2006
    Place of death was determined for all 58,689 seniors (age > or = 66 years) in Ontario who died during fiscal year 2001/2002...
  25. ncbi Excess weight at time of presentation of myocardial infarction is associated with lower initial mortality risks but higher long-term risks including recurrent re-infarction and cardiac death
    Anil Nigam
    Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Int J Cardiol 110:153-9. 2006
    ..To evaluate the influence of elevated body mass index (BMI) on short- and long-term survival following acute myocardial infarction (AMI)...
  26. pmc Manganese superoxide dismutase: beyond life and death
    Aaron K Holley
    University of Kentucky, Lexington, USA
    Amino Acids 42:139-58. 2012
    ..The results demonstrate the role of MnSOD beyond its essential role for survival and suggest a novel strategy for an antioxidant approach to cancer intervention...
  27. ncbi New insights on brain stem death: from bedside to bench
    Julie Y H Chan
    Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81346, Taiwan, ROC
    Prog Neurobiol 77:396-425. 2005
    As much as brain stem death is currently the clinical definition of death in many countries and is a phenomenon of paramount medical importance, there is a dearth of information on its mechanistic underpinnings...
  28. pmc Inability to obtain deferred consent due to early death in emergency research: effect on validity of clinical trial results
    Tim C Jansen
    Department of Intensive Care, Erasmus MC University Medical Center, CA, Rotterdam, The Netherlands
    Intensive Care Med 36:1962-5. 2010
    ..To illustrate the impact on the validity of trial results due to excluding patients from a randomized controlled trial for whom no deferred consent could be obtained after randomization because study procedures had already been finished...
  29. ncbi Does the arousal system contribute to near death experience?
    Kevin R Nelson
    Department of Neurology, University of Kentucky, Lexington, KY, USA
    Neurology 66:1003-9. 2006
    The neurophysiologic basis of near death experience (NDE) is unknown. Clinical observations suggest that REM state intrusion contributes to NDE...
  30. ncbi Anxiety and depression in parents 4-9 years after the loss of a child owing to a malignancy: a population-based follow-up
    Ulrika Kreicbergs
    Clinical Cancer Epidemiology, Department of Oncology and Pathology, Karolinska Institutet Z6 01, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    Psychol Med 34:1431-41. 2004
    Some consider the loss of a child as the most stressful life event. When the death is caused by a malignancy, the parents are commonly exposed not only to their own loss, but also to the protracted physical and emotional suffering of the ..
  31. doi Prediction of recurrent stroke and vascular death in patients with transient ischemic attack or nondisabling stroke: a prospective comparison of validated prognostic scores
    Christian Weimar
    Department of Neurology, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
    Stroke 41:487-93. 2010
    ..We aimed to prospectively compare the predictive accuracy of the Essen Stroke Risk Score, Stroke Prognostic Instrument, Hankey score, and the Life Long After Cerebral ischemia score...
  32. pmc Epidemiological pathology of dementia: attributable-risks at death in the Medical Research Council Cognitive Function and Ageing Study
    Fiona E Matthews
    Medical Research Council MRC Biostatistics, University of Cambridge, Cambridge, United Kingdom
    PLoS Med 6:e1000180. 2009
    ..We report the attributable risks (ARs) for dementia at death for common age-related degenerative and vascular pathologies, and other factors, in the MRC Cognitive Function and ..
  33. ncbi Nurses' experiences with hospice patients who refuse food and fluids to hasten death
    Linda Ganzini
    Department of Veterans Affairs, Oregon Health and Science University, Portland, Oreg, USA
    N Engl J Med 349:359-65. 2003
    Voluntary refusal of food and fluids has been proposed as an alternative to physician-assisted suicide for terminally ill patients who wish to hasten death. There are few reports of patients who have made this choice.
  34. doi Phenomenology of near-death experiences: a cross-cultural perspective
    John Belanti
    Broadmeadows Adult Community Mental Health, Broadmeadows VIC 3407, Australia
    Transcult Psychiatry 45:121-33. 2008
    Near-death experiences (NDEs) include a set of subjective experiences encountered by people who were close to death or were faced with life-threatening situations...
  35. ncbi Ischemic cholangiopathy following liver transplantation from donation after cardiac death donors
    Edie Y Chan
    Division of Transplantation, Department of Surgery, University of Washington, Seattle, WA 98195, USA
    Liver Transpl 14:604-10. 2008
    The use of donation after cardiac death (DCD) donor hepatic allografts is becoming more widespread; however, there have been published reports of increased graft failure from specific complications associated with this type of allograft...
  36. doi A subset of circulating microRNAs are predictive for cardiac death after discharge for acute myocardial infarction
    Sen Matsumoto
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Biochem Biophys Res Commun 427:280-4. 2012
    ..667 miRs, 11 miRs were found to be differentially expressed in the serum among patients at high-risk for cardiac death. Real-time RT-PCR confirmed that the serum levels of miR-155 and miR-380* were approximately 4- and 3-fold higher, ..
  37. pmc Right ventricular structure is associated with the risk of heart failure and cardiovascular death: the Multi-Ethnic Study of Atherosclerosis (MESA)--right ventricle study
    Steven M Kawut
    Penn Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia
    Circulation 126:1681-8. 2012
    ..We examined the association of abnormal RV structure and function with the risk of heart failure or cardiovascular death in a population-based multiethnic sample free of clinical cardiovascular disease at baseline.
  38. ncbi DSCAM deficiency causes loss of pre-inspiratory neuron synchroneity and perinatal death
    Kenji Amano
    Laboratory for Neurogenetics, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    J Neurosci 29:2984-96. 2009
    ..These results suggest that DSCAM plays a critical role in central respiratory regulation in a dosage-dependent manner...
  39. doi Determinants of the place of death in the Brussels metropolitan region
    Dirk Houttekier
    End of Life Care Research Group, Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels 1090, Belgium
    J Pain Symptom Manage 37:996-1005. 2009
    The place where people die is not only considered an indicator of quality of death, but also has implications for health care costs and the organization of end-of-life care...
  40. doi Increased risk of severe recurrence of hepatitis C virus in liver transplant recipients of donation after cardiac death allografts
    Roberto Hernandez-Alejandro
    Multi Organ Transplant Program, London Health Sciences Centre, University Hospital, London, ON, Canada
    Transplantation 92:686-9. 2011
    In hepatitis C virus (HCV) recipients of donation after cardiac death (DCD) grafts, there is suggestion of lower rates of graft survival, indicating that DCD grafts themselves may represent a significant risk factor for severe recurrence ..
  41. ncbi Liver transplantation using Donation after Cardiac Death donors
    Diethard Monbaliu
    Catholic University Leuven, Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium
    J Hepatol 56:474-85. 2012
    ..All countries have strived to expand donor numbers beyond the standard Donation after Brain Death (DBD)...
  42. ncbi The effect of normothermic recirculation before cold preservation on post-transplant injury of ischemically damaged donor kidneys
    Cyril Moers
    Surgery Research Laboratory, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Transpl Int 25:210-7. 2012
    Kidneys recovered from donation after cardiac death (DCD) are increasingly used to enlarge the deceased donor pool...
  43. pmc Decapitation in rats: latency to unconsciousness and the 'wave of death'
    Clementina M Van Rijn
    Department of Biological Psychology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
    PLoS ONE 6:e16514. 2011
    ..massive wave which can be recorded approximately one minute after decapitation reflects the ultimate border between life and death. This observation might have implications in the discussions on the appropriate time for organ donation.
  44. doi Pilot study on traumatic grief treatment program for Japanese women bereaved by violent death
    Nozomu Asukai
    Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
    J Trauma Stress 24:470-3. 2011
    ..Based on Jacobson's Reliable Change Index, 46% showed change on all 3 measures. These findings suggest that our treatment model may be feasible for treating traumatic grief with PTSD in non-Western settings...
  45. doi Surges of electroencephalogram activity at the time of death: a case series
    Lakhmir S Chawla
    Department of Critical Care Medicine and Anesthesiology, George Washington University Medical Center, Washington, DC 20037, USA
    J Palliat Med 12:1095-100. 2009
    ..increase in electrical activity occurred when there was no discernable blood pressure, patients who suffer "near death" experiences may be recalling the aggregate memory of the synaptic activity associated with this terminal but ..
  46. pmc Parental death during childhood and adult cardiovascular risk in a developing country: the Guangzhou Biobank Cohort Study
    C Mary Schooling
    Department of Community Medicine, School of Public Health, The University of Hong Kong, Hong Kong SAR, China
    PLoS ONE 6:e19675. 2011
    ..We examined the association of a potential marker of childhood emotional adversity with cardiovascular disease risk factors in a developing country...
  47. pmc Distributions of observed death tolls govern sensitivity to human fatalities
    Christopher Y Olivola
    Department of Cognitive, Perceptual, and Brain Sciences, University College London, London WC1H 0AP, United Kingdom
    Proc Natl Acad Sci U S A 106:22151-6. 2009
    ..the loss of human lives depends largely on the extent to which we are moved by the size of their associated death tolls...
  48. ncbi Serum neutrophil gelatinase-associated lipocalin as a predictor of organ recovery from delayed graft function after kidney transplantation from donors after cardiac death
    Mamoru Kusaka
    Dept of Urol, Div of Molecular Genetics, Inst for Comp Med Sci and 21st Century COE Program, Dev Center for Targeted and Minimally Invasive Diagnosis and Treatment, Fujita Health University School of Medicine, Japan
    Cell Transplant 17:129-34. 2008
    Because of a worldwide shortage of renal grafts, kidneys procured from donors after cardiac death (DCD) have recently become an important source of renal transplants...
  49. ncbi Good death inventory: a measure for evaluating good death from the bereaved family member's perspective
    Mitsunori Miyashita
    Department of Adult Nursing Palliative Care Nursing, School of Health Sciences and Nursing, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Pain Symptom Manage 35:486-98. 2008
    The aim of this study was to develop a measure for evaluating good death from the bereaved family member's perspective, and to examine the validity and reliability of the assessment...
  50. doi Long-term evolution of 5S ribosomal DNA seems to be driven by birth-and-death processes and selection in Ensis razor shells (Mollusca: Bivalvia)
    Joaquín Vierna
    Department of Molecular and Cell Biology, Evolutionary Biology Group GIBE, Universidade da Coruna, A Zapateira s n, La Coruña 15071, Spain
    Biochem Genet 47:635-44. 2009
    ..These results strongly suggest that the long-term evolution of Ensis 5S ribosomal DNA is driven by birth-and-death processes and selection.
  51. ncbi Psychiatric morbidity, violent crime, and suicide among children and adolescents exposed to parental death
    Holly C Wilcox
    Johns Hopkins University, Baltimore, MD 21287 3325, USA
    J Am Acad Child Adolesc Psychiatry 49:514-23; quiz 530. 2010
    ..This retrospective cohort study examined the risk for suicide, psychiatric hospitalization, and violent criminal convictions among offspring of parents who died from suicide, accidents, and other causes...
  52. pmc Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease
    Gregory J Kato
    Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Dr, MSC 1476, Bldg 10CRC, Rm 5 5140, Bethesda, MD 20892, USA
    Blood 107:2279-85. 2006
    ..was associated with a clinical subphenotype of pulmonary hypertension, leg ulceration, priapism, and risk of death in patients with sickle cell disease...
  53. ncbi Controlling death: the false promise of advance directives
    Henry S Perkins
    Ecumenical Center for Religion and Health and Division of General Medicine, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Ann Intern Med 147:51-7. 2007
    ....
  54. pmc Actual and preferred place of death of cancer patients. Results from the Italian survey of the dying of cancer (ISDOC)
    Monica Beccaro
    Unit of Clinical Epidemiology, National Cancer Institute, Largo Rosanna Benzi, 10, 16132, Genoa, Italy
    J Epidemiol Community Health 60:412-6. 2006
    To describe actual and preferred place of death of Italian cancer patients and to analyse the preferences met regarding the place of death.
  55. ncbi Extracorporeal support for organ donation after cardiac death effectively expands the donor pool
    Joseph F Magliocca
    Department of Surgery, The University of Wisconsin School of Medicine, Madison WI, USA
    J Trauma 58:1095-101; discussion 1101-2. 2005
    ..normothermic, extracorporeal perfusion (ECMO) for donation of abdominal organs for transplantation after cardiac death (DCD)...
  56. ncbi A measure of the quality of dying and death. Initial validation using after-death interviews with family members
    J Randall Curtis
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Pain Symptom Manage 24:17-31. 2002
    ..To describe the validity of an instrument assessing the quality of dying and death using the perspective of family members after death and to identify clinical correlates of a high quality death, a ..
  57. ncbi Near-death experiences in cardiac arrest survivors
    Christopher C French
    Anomalistic Psychology Research Unit, Department of Psychology, Goldsmiths College, University of London, New Cross, London SE14 6NW, UK
    Prog Brain Res 150:351-67. 2005
    Near-death experiences (NDEs) have become the focus of much interest in the last 30 years or so. Such experiences can occur both when individuals are objectively near to death and also when they simply believe themselves to be...
  58. ncbi Near-death experiences and the temporal lobe
    Willoughby B Britton
    Department of Psychology, University of Arizona, Tucson, AZ 85721, USA
    Psychol Sci 15:254-8. 2004
    ..We investigated temporal lobe functioning in individuals who reported having transcendental "near-death experiences" during life-threatening events...
  59. ncbi Incidence and correlates of near-death experiences in a cardiac care unit
    Bruce Greyson
    Department of Psychiatric Medicine, University of Virginia Health System, Charlottesville, VA, USA
    Gen Hosp Psychiatry 25:269-76. 2003
    Near-death experiences, unusual experiences during a close brush with death, may precipitate pervasive attitudinal and behavior changes...
  60. ncbi The last 3 months of life: care, transitions and the place of death of older people
    Marianne Klinkenberg
    Department of Palliative Care, Comprehensive Cancer Centre, Amsterdam, The Netherlands
    Health Soc Care Community 13:420-30. 2005
    ..Little is known about the factors associated with place of death. The aim of the present study was to investigate the care received by older people in the last 3 months of their ..
  61. ncbi Donation after cardiac death in the US: history and use
    Peter L Abt
    Division of Solid Organ Transplantation, Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA
    J Am Coll Surg 203:208-25. 2006
  62. pmc The accuracy of histological assessments of dental development and age at death
    T M Smith
    Department of Anthropology, Stony Brook University, USA
    J Anat 208:125-38. 2006
    ..Using known-period incremental features, the crown formation time and age at death of five pig-tailed macaques (Macaca nemestrina) were estimated with standard histological techniques and compared ..
  63. doi Cardiac related death in thalassaemia major: time trend and risk factors in a large Greek Unit
    Giorgos Chouliaras
    Thalassaemia Unit, First Department of Paediatrics, Aghia Sophia Children s Hospital, Athens, Greece
    Eur J Haematol 82:381-7. 2009
    Cardiac complications are the leading cause of death in thalassaemic patients (TM) worldwide...
  64. ncbi Transforming self-rated health and the SF-36 scales to include death and improve interpretability
    P Diehr
    Department of Biostatistics, University of Washington, Seattle, Washington 98195-7232, USA
    Med Care 39:670-80. 2001
    ..EVGGFP) and the physical component score of the SF-36 (PCS) to new variables that include a defensible value for death. METHODS: Using longitudinal data from two large studies of older adults, health variables were transformed to the ..
  65. pmc Trends in the place of death of cancer patients, 1992-1997
    Frederick Burge
    Department of Family Medicine, Dalhousie University, Halifax, NS
    CMAJ 168:265-70. 2003
    ..We carried out a study to describe the yearly trends in the place of death between 1992 and 1997 and to determine predictors of out-of-hospital death for adults with cancer in Nova Scotia.
  66. doi Prediction of cardiac death in hemodialysis patients by myocardial fatty acid imaging
    Masato Nishimura
    Cardiovascular Division, Toujinkai Hospital, Kyoto, Japan
    J Am Coll Cardiol 51:139-45. 2008
    The aim was to evaluate the potential of single-photon emission computed tomography (SPECT) to predict cardiac death in chronic hemodialysis patients using the iodinated fatty acid analogue iodine-123 123I-beta-methyl iodophenyl-..
  67. doi Donating hearts after cardiac death--reversing the irreversible
    Robert M Veatch
    Kennedy Institute of Ethics, Georgetown University, Washington, DC, USA
    N Engl J Med 359:672-3. 2008
  68. doi The boundaries of organ donation after circulatory death
    James L Bernat
    Dartmouth Medical School, Hanover, NH, USA
    N Engl J Med 359:669-71. 2008
  69. ncbi ASTS recommended practice guidelines for controlled donation after cardiac death organ procurement and transplantation
    D J Reich
    Drexel University College of Medicine, Philadelphia, PA, USA
    Am J Transplant 9:2004-11. 2009
    ..Controlled donation after cardiac death (DCD) offers the family and the patient with a hopeless prognosis the option to donate when brain death criteria ..
  70. ncbi A longitudinal study of the effects of age and time to death on hospital costs
    Meena Seshamani
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Health Econ 23:217-35. 2004
    Recent studies indicate that approaching death, rather than age, may be the main demographic driver of health care costs...
  71. pmc Smooth and cardiac muscle-selective knock-out of Kruppel-like factor 4 causes postnatal death and growth retardation
    Tadashi Yoshida
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    J Biol Chem 285:21175-84. 2010
    ..In vivo chromatin immunoprecipitation assays on the heart revealed that Klf4 bound to the promoter region of the Gata4 gene. Results provide novel evidence that Klf4 plays a key role in late fetal and/or postnatal cardiac development...
  72. ncbi Preferred place of care and place of death of the general public and cancer patients in Japan
    Akemi Yamagishi
    Department of Nursing, Seirei Christopher University, Hamamatsu, Shizuoka, Japan
    Support Care Cancer 20:2575-82. 2012
    ..The primary aim was to clarify (1) differences in preferred place of care and place of death among the general public across four areas across Japan and (2) preferred place of care and place of death among ..
  73. pmc Order, disorder, death: lessons from a superorganism
    Gro V Amdam
    Arizona State University, School of Life Sciences, Tempe, Arizona 85287, USA
    Adv Cancer Res 95:31-60. 2006
    ..A facultatively sterile caste, the workers, regulates patterns of growth, differentiation, homeostasis, and death. Workers differentiate into temporal phenotypes in response to dynamic social cues; chemosensory signals that can ..
  74. ncbi A retrospective analysis of preferred and actual place of death for hospice patients
    Laura Holdsworth
    University of Kent, UK
    Int J Palliat Nurs 16:424, 426, 428 passim. 2010
    The purpose of this study was to explore recording rates of preferences, and the preferred and actual place of death among hospice patients. Data was collected retrospectively from a group of three hospices over a 6-month period...
  75. pmc Social inequality and death as illustrated in late-medieval death dances
    J P Mackenbach
    Department of Public Health, Erasmus University, Rotterdam, The Netherlands
    Am J Public Health 85:1285-92. 1995
    Late-medieval murals and books of the then-popular "dances of death" usually represented the living according to their social standing...
  76. pmc The dead donor rule: can it withstand critical scrutiny?
    Franklin G Miller
    National Institutes of Health, Bethesda, MD 20892 1156, USA
    J Med Philos 35:299-312. 2010
    ..rationale for the DDR by rejecting the underlying premise that it is necessarily wrong for physicians to cause the death of patients and the claim that abandoning this rule would exploit vulnerable patients...
  77. ncbi The ethics of creating and responding to doubts about death criteria
    James M DuBois
    Saint Louis University, 221 N Grand Blvd, St Louis, MO 63103, USA
    J Med Philos 35:365-80. 2010
    Expressing doubts about death criteria can serve healthy purposes, but can also cause a number of harms, including decreased organ donation rates and distress for donor families and health care staff...
  78. doi Ethical controversies at end of life after traumatic brain injury: defining death and organ donation
    Michael Souter
    Department of Anesthesiology and Pain Medicine and Neurosurgery, Harborview Medical Center, University of Washington, Seattle, WA, USA
    Crit Care Med 38:S502-9. 2010
    b>Death is more than a mere biological occurrence. It has important legal, medical, and social ramifications that make it imperative that those who are responsible for determination of death be accurate and above suspicion...
  79. doi Survey of pediatricians' opinions on donation after cardiac death: are the donors dead?
    Ari R Joffe
    Department of Pediatrics, University of Alberta and Stollery Children s Hospital, Edmonton, Alberta, Canada
    Pediatrics 122:e967-74. 2008
    There has been debate in the ethics literature as to whether the donation-after-cardiac-death donor is dead after 5 minutes of absent circulation...
  80. ncbi The thin flat line: redefining who is legally dead in organ donation after cardiac death
    Maxine M Harrington
    Texas Wesleyan University School of Law, USA
    Issues Law Med 25:95-143. 2009
    The debate over whether donation after cardiac death (DCD) donors are truly dead is not new but has surfaced mostly in the academic community...
  81. doi Using students' journals about death experiences as a pedagological tool
    Kevin Doll
    Department of Human Development and Family Studies, University of Wisconsin Stout, Menomie, WI, USA
    Gerontol Geriatr Educ 29:124-38. 2008
    The purpose of this article is to evaluate a pedagological tool for student's study of death and bereavement...
  82. ncbi Grief shortly after suicide and natural death: a comparative study among spouses and first-degree relatives
    M H de Groot
    Department of Social Psychiatry at the University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Suicide Life Threat Behav 36:418-31. 2006
    ..the felt need for professional help was higher among the former, even after adjustment for expectedness of death, sociodemographic differences, and relatives'/spouses' neuroticism...
  83. ncbi Using livers from donation after cardiac death donors--a proposal to protect the true Achilles heel
    John J Fung
    Liver Transpl 13:1633-6. 2007
  84. ncbi Liver transplantation following donation after cardiac death: an analysis using matched pairs
    James K Pine
    Department of Hepatobiliary Transplant Surgery, St James s University Hospital, Beckett Street, United Kingdom
    Liver Transpl 15:1072-82. 2009
    Grafts from donation after cardiac death (DCD) donors are used to increase the number of organs available for liver transplantation. There is concern that warm ischemia may impair graft function...
  85. ncbi Death and conception
    G Bahadur
    Department of Obstetrics and Gynaecology, Fertility and Reproductive Medicine Laboratories, Royal Free and University College Medical School, London, UK
    Hum Reprod 17:2769-75. 2002
    ..This may be achieved by offering ample time for informed and support counselling. Finally, consideration should be expressed for the welfare of unborn child, in a balanced, pragmatic and sensible manner...
  86. pmc The impact of ischemic cholangiopathy in liver transplantation using donors after cardiac death: the untold story
    Anton I Skaro
    Division of Organ Transplantation, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Surgery 146:543-52; discussion 552-3. 2009
    Liver transplantation (LT) from donation after cardiac death (DCD) donors is increasingly being used to address organ shortages. Despite encouraging reports, standard survival metrics have overestimated the effectiveness of DCD livers...
  87. ncbi The prevalence of PTSD following the violent death of a child and predictors of change 5 years later
    Shirley A Murphy
    Department of Psychosocial and Community Health, School of Nursing, University of Washington, Seattle, Washington 98195 7263, USA
    J Trauma Stress 16:17-25. 2003
    In this study, we examined the violent death bereavement trajectories of 173 parents by following them prospectively for 5 years after their children's deaths by accident, suicide, homicide, or undetermined causes...
  88. ncbi Peritoneal cooling may provide improved protection for uncontrolled donors after cardiac death: an exploratory porcine study
    A P Navarro
    Liver, Renal and Pancreatic Transplant Unit, Freeman Hospital, Newcastle upon Tyne, UK
    Am J Transplant 9:1317-23. 2009
    Uncontrolled donation after cardiac death (DCD) renal transplantation relies on rapid establishment of organ preservation interventions...
  89. ncbi Line-of-duty death: psychological treatment of traumatic bereavement in law enforcement
    Laurence Miller
    Int J Emerg Ment Health 9:13-23. 2007
    A line-of-duty death (LODD) strikingly brings home the risk and vulnerability of all law enforcement officers and affects the officer's peers, the entire department, the wider police community, and the officer's family...
  90. pmc Non-heart beating organ donation: old procurement strategy--new ethical problems
    M D D Bell
    Intensive Care, The General Infirmary at Leeds, Great George Street, Leeds LS1 3EX, UK
    J Med Ethics 29:176-81. 2003
    ..on necessity, the process may constitute a desirable outcome for patient and family when progression to brain stem death (BSD) does not occur and conventional organ retrieval from the beating heart donor is thereby prevented...
  91. doi Donation after cardiac death: a survey of university student opinions on death and donation
    Ari R Joffe
    Department of Pediatrics, 3A3 Stollery Children s Hospital, University of Alberta, 8440 112 Street, Edmonton, AB, T6G 2B7, Canada
    Intensive Care Med 35:240-7. 2009
    To determine if university students consider the donation after cardiac death donor as dead.
  92. ncbi Changing pattern of organ donation at a single center: are potential brain dead donors being lost to donation after cardiac death?
    R F Saidi
    Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Transplant 10:2536-40. 2010
    Donation after cardiac death (DCD) has proven effective at increasing the availability of organs for transplantation...
  93. pmc What is a natural cause of death? A survey of how coroners in England and Wales approach borderline cases
    I S Roberts
    Department of Pathological Sciences, University of Manchester, UK
    J Clin Pathol 53:367-73. 2000
    ..There are no guidelines to help doctors in dealing with such cases and death certification is often arbitrary and inconsistent...
  94. doi Risk of myocardial infarction and death associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) among healthy individuals: a nationwide cohort study
    E L Fosbøl
    Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark
    Clin Pharmacol Ther 85:190-7. 2009
    ..Using a historical cohort design, we estimated the risk of death and myocardial infarction associated with the use of NSAIDs...
  95. ncbi Beta-blockers reduce the risk of early death in ischemic stroke
    Tomasz Dziedzic
    Department of Neurology, Jagiellonian University, Botaniczna 3, 31 503 Krakow, Poland
    J Neurol Sci 252:53-6. 2007
    ..Experimental studies suggest that beta-blockers have also neuroprotective properties. The aim of this study was to assess if use of beta-blockers is associated with reduced risk of early death in ischemic stroke patients.
  96. ncbi Organ donation after cardiac death: legal and ethical justifications for antemortem interventions
    James Tibballs
    Med J Aust 188:186-7; author reply 188. 2008
  97. ncbi A statistical analogy between collapse of solids and death of living organisms: proposal for a 'law of life'
    Nicola M Pugno
    Department of Structural Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy
    Med Hypotheses 69:441-7. 2007
    ..collapse of solids and living organisms; in particular we deduce a statistical law governing their probability of death. We have derived such a law coupling the widely used Weibull Statistics, developed for describing the distribution ..
  98. ncbi Machine perfusion as a tool to select kidneys recovered from uncontrolled donors after cardiac death
    O N Reznik
    St Petersburg State Research Institute for Emergency named after I I Dzhanelidze, Saint Petersburg, Russia
    Transplant Proc 40:1023-6. 2008
    The use of kidneys from uncontrolled donors after cardiac death (uDCD) remains disputable due to significant warm ischemia time (WIT) causing ischemia-reperfusion injuries...
  99. doi Controlled non-heart beating organ donation: neither the whole solution nor a step too far
    P Murphy
    The General Infirmary, Leeds, UK
    Anaesthesia 63:526-30. 2008
    ..care pathway in order to allow donation to take place, and, finally, an uncertainty over how soon after cardiac death organ retrieval can begin...
  100. ncbi Talking about death with children who have severe malignant disease
    Ulrika Kreicbergs
    Division of Clinical Cancer Epidemiology, Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden
    N Engl J Med 351:1175-86. 2004
    One of the questions faced by the parents of a child who is terminally ill with a malignant disease is whether or not they should talk about death with their child.
  101. ncbi Disability occurrence and proximity to death
    Bart Klijs
    Department of Public Health, Erasmus MC, Rotterdam, The Netherlands
    Disabil Rehabil 32:1733-41. 2010
    This paper aims to assess whether disability occurrence is related more strongly to proximity to death than to age.

Research Grants95

  1. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  2. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  3. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  4. A Network Biology Approach to Antibiotic Action and Bacterial Defense Mechanisms
    James Collins; Fiscal Year: 2009
    ..strains of bacteria, a better understanding of the specific sequences of events leading to cell death from bactericidal antibiotics is needed for future antibacterial drug development...
  5. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS DELL ITALIA; Fiscal Year: 2009
    ..The injury culminates in the death of cardiomyocytes that were viable immediately before myocardial reperfusion and occurs despite timely reperfusion ..
  6. Il-7 receptor signaling in lymphopoiesis
    Motonari Kondo; Fiscal Year: 2009
    ..governed by IL-7? receptor signaling include initiation offcell proliferation, protection from apoptotic cell death, and the induction oflineage-speciifiicevents, such as gene rearangement in antiigen receptor loacdi...
  7. Intracavitary Hemostatic Agent for Non-compressible Hemorrhage
    Maja Nowakowski; Fiscal Year: 2009
    Hemorrhage resulting from traumatic injuries is a major cause of death in accidents, and the primary cause of death on the battlefield. Over 40% of the trauma cases admitted at hospitals in the USA, are due to road traffic accidents...
  8. Intracavitary Hemostatic Agent for Non-compressible Hemorrhage
    Maja Nowakowski; Fiscal Year: 2010
    Hemorrhage resulting from traumatic injuries is a major cause of death in accidents, and the primary cause of death on the battlefield. Over 40% of the trauma cases admitted at hospitals in the USA, are due to road traffic accidents...
  9. Intracavitary Hemostatic Agent for Non-compressible Hemorrhage
    Maja Nowakowski; Fiscal Year: 2010
    Hemorrhage resulting from traumatic injuries is a major cause of death in accidents, and the primary cause of death on the battlefield. Over 40% of the trauma cases admitted at hospitals in the USA, are due to road traffic accidents...
  10. TESTING THE DNA-CALCIUM HYPOTHESIS OF TOXIC CELL DEATH
    George Corcoran; Fiscal Year: 1993
    Alkylation by reactive chemicals or metabolites causes toxic cell death or necrosis. Our ability to prevent such cell death is limited by an incomplete understanding of the process...
  11. Combination drug treatment to inhibit multiple cell death pathways after TBI
    ALAN FADEN; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): This application entitled "Attenuation of Diverse Cell Death Pathways after Traumatic Brain Injury by Multi- drug Combination Therapy" addresses Broad Challenge Area (15): Translational Science and ..
  12. Combination drug treatment to inhibit multiple cell death pathways after TBI
    ALAN FADEN; Fiscal Year: 2009
    This application entitled "Attenuation of Diverse Cell Death Pathways after Traumatic Brain Injury by Multi- drug Combination Therapy" addresses Broad Challenge Area (15): Translational Science and Specific Challenge Topic: 15-HD-104, ..
  13. Combination drug treatment to inhibit multiple cell death pathways after TBI
    ALAN IRA FADEN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): This application entitled "Attenuation of Diverse Cell Death Pathways after Traumatic Brain Injury by Multi- drug Combination Therapy" addresses Broad Challenge Area (15): Translational Science and ..
  14. Use of Beta-Lapachone for Lung Cancer Chemotherapy
    David Boothman; Fiscal Year: 2007
    Use of B-lapachone for non-small cell lung cancer (NSCLC) therapy Lung cancer is the leading cause of death by cancer in the U.S. Non-small cell lung cancer (NSCLC) comprises over 75% of lung cancers diagnosed...
  15. Use of Beta-Lapachone for Lung Cancer Chemotherapy
    David Boothman; Fiscal Year: 2007
    Use of B-lapachone for non-small cell lung cancer (NSCLC) therapy Lung cancer is the leading cause of death by cancer in the U.S. Non-small cell lung cancer (NSCLC) comprises over 75% of lung cancers diagnosed...
  16. Bilirubin oxidation and intracerebral hemorrhage
    Joseph Clark; Fiscal Year: 2006
    ..Intracerebral hemorrhage (ICH) is a type of stroke caused by bleeding into the brain, resulting in significant death and disability...
  17. Prognostic Impact and Arrhythmic Potential of Peri-infarct Zone by Cardiac MRI
    Raymond Y Kwong; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The incidence of sudden cardiac death (SCD) after myocardial infarction (MI) has remained unchanged and is most significant in the first year after MI...
  18. Prognostic Impact and Arrhythmic Potential of Peri-infarct Zone by Cardiac MRI
    Raymond Kwong; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The incidence of sudden cardiac death (SCD) after myocardial infarction (MI) has remained unchanged and is most significant in the first year after MI...
  19. Research Study to Assess the Risk of Blood Borne Transmission of Creutzfeldt-Jako
    Shimian Zou; Fiscal Year: 2009
    ..identified in this study and continue to monitor these recipients'vital status, including the causes of death should they die;5) continue a plan that will (a) search national, state, and local organizations databases to ..
  20. Research Study to Assess the Risk of Blood Borne Transmission of Creutzfeldt-Jako
    Shimian Zou; Fiscal Year: 2010
    ..identified in this study and continue to monitor these recipients'vital status, including the causes of death should they die;5) continue a plan that will (a) search national, state, and local organizations databases to ..
  21. Staphylococcal biofilm and disease
    Kenneth Bayles; Fiscal Year: 2009
    ..application includes four projects centered around staphylococcal biofilm and disease including: regulated cell death during biofilm development (Project 1, K...
  22. RTP801 and ATF4 in Neuronal Death in PD
    OREN ABRAHAM LEVY; Fiscal Year: 2010
    ..Since joining the lab I have authored a review article on cell death mechanisms in Parkinson's disease...
  23. Rituximab Elicitation of Tumor Specific T-cell Responses in Lymphoma Patients
    Steven Bernstein; Fiscal Year: 2009
    ..Rituximab induced FL cell death is expected to result in the release of tumor antigens, for example antigens derived from the variable regions of ..
  24. Tumorigenic role of mitochondria in African-American women
    Keshav K Singh; Fiscal Year: 2010
    ..These functions include ATP production via oxidative phosphorylation (OXPHOS), control of cell growth, cell death, development and various metabolic pathways...
  25. Extracorporeal Support for Emergent (Uncontrolled) Donation Following Cardiac Dea
    Shawn J Pelletier; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Extracorporeal Support for Emergent (Uncontrolled) Donation Following Cardiac Death Introduction: The limited availability of donor organs for transplantation has led to an increased interest in the ..
  26. Extracorporeal Support for Emergent (Uncontrolled) Donation Following Cardiac Dea
    Shawn Pelletier; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Extracorporeal Support for Emergent (Uncontrolled) Donation Following Cardiac Death Introduction: The limited availability of donor organs for transplantation has led to an increased interest in the ..
  27. Neonatal Long QT Syndrome and Sudden Infant Death
    Alfred L George; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Sudden death during the first year of life is a leading cause of infant mortality in developed countries...
  28. Neonatal Long QT Syndrome and Sudden Infant Death
    ALFRED GEORGE; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Sudden death during the first year of life is a leading cause of infant mortality in developed countries...
  29. Neonatal Long QT Syndrome and Sudden Infant Death
    ALFRED GEORGE; Fiscal Year: 2007
    Sudden death during the first year of life is a leading cause of infant mortality in developed countries...
  30. Mechanisms and Modulation of Cell Death in Traumatic Brain Injury
    ALAN IRA FADEN; Fiscal Year: 2010
    ..However, some of these studies indicate that improvements often reflect only a delay in cell death, which still occurs eventually without the classical apoptotic phenotype...
  31. Mechanisms and Modulation of Cell Death in Traumatic Brain Injury
    ALAN IRA FADEN; Fiscal Year: 2009
    ..However, some of these studies indicate that improvements often reflect only a delay in cell death, which still occurs eventually without the classical apoptotic phenotype...
  32. Mechanisms and Modulation of Cell Death in Traumatic Brain Injury
    ALAN FADEN; Fiscal Year: 2009
    ..However, some of these studies indicate that improvements often reflect only a delay in cell death, which still occurs eventually without the classical apoptotic phenotype...
  33. Regulation of myocardial growth and death by GSK-3
    Junichi Sadoshima; Fiscal Year: 2010
    ..Glycogen synthase kinase-3 (GSK-3), a serine/threonine kinase, plays an important role in regulating growth and death of cardiomyocytes...
  34. TNF-alpha in cell death & neuroprotection in glaucoma
    GULGUN TEZEL; Fiscal Year: 2003
    ..cause of worldwide blindness, neither the precise pathogenic mechanisms, which lead to retinal ganglion cell death in glaucoma, nor effective strategies for neuroprotection are known...
  35. TNF-alpha in cell death & neuroprotection in glaucoma
    GULGUN TEZEL; Fiscal Year: 2006
    ..cause of worldwide blindness, neither the precise pathogenic mechanisms, which lead to retinal ganglion cell death in glaucoma, nor effective strategies for neuroprotection are known...
  36. TNF-alpha in cell death & neuroprotection in glaucoma
    GULGUN TEZEL; Fiscal Year: 2004
    ..cause of worldwide blindness, neither the precise pathogenic mechanisms, which lead to retinal ganglion cell death in glaucoma, nor effective strategies for neuroprotection are known...
  37. TNF-alpha in cell death & neuroprotection in glaucoma
    GULGUN TEZEL; Fiscal Year: 2005
    ..cause of worldwide blindness, neither the precise pathogenic mechanisms, which lead to retinal ganglion cell death in glaucoma, nor effective strategies for neuroprotection are known...
  38. Unfolded Protein Response in Lens Epithelial Cells
    Toshimichi Shinohara; Fiscal Year: 2009
    ..cataractogenic stressors also exhibit endoplasmic reticulum (ER) stress and induce well-defined protective and death pathways called the unfolded protein response (UPR)...
  39. Significance of Caspase-Mediated Cleavage of PARP-1 in Cell Death
    KAREN DAVID; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Significance of Caspase-Mediated Cleavage of PARP-1 in Cell Death Poly (ADP-ribose) polymerase-1 (PARP-1) maintains cell function by facilitating DNA repair...
  40. Systematic analysis of cell death regulation in mosquitoes
    Lei Zhou; Fiscal Year: 2009
    Title: Systematic analysis of cell death regulation in mosquitoes. Cell death (apoptosis) is an important component of the vector/host immuno-response mechanism...
  41. Innate Immune Mechanisms of Motor Neuron Injury
    Timothy Vartanian; Fiscal Year: 2010
    ..Relatedness: A central question in neurodegenerative diseases is how specific populations of neurons undergo cell death. Selective degeneration of motor neurons occurs in the setting of diverse insults including RNA viruses such as ..
  42. Innate Immune Mechanisms of Motor Neuron Injury
    Timothy Vartanian; Fiscal Year: 2009
    ..Relatedness: A central question in neurodegenerative diseases is how specific populations of neurons undergo cell death. Selective degeneration of motor neurons occurs in the setting of diverse insults including RNA viruses such as ..
  43. The mitochondrial permeability transition and heart failure
    William Craigen; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Mitochondria are central in both energy production and cellular death pathways, yet a variety of questions concerning structure-function relationships of mitochondria remain poorly ..
  44. The role of intracellular calcium in ototoxin-mediated hair cell death
    Robert Esterberg; Fiscal Year: 2011
    ..Our lab is investigating the causative role of these drugs in hair cell death in hopes of identifying protective strategies...
  45. Characterizing autonomic dysfunction in Rett syndrome and other MECP2 disorders
    Jeffrey L Neul; Fiscal Year: 2012
    ..have a number of autonomic abnormalities including bradycardia, apnea, and respiratory arrest resulting in death in the first three years of life...
  46. Characterization of autonomic dysfunction in Rett syndrome and other MECP2 disord
    Jeffrey L Neul; Fiscal Year: 2010
    ..have a number of autonomic abnormalities including bradycardia, apnea, and respiratory arrest resulting in death in the first three years of life...
  47. Sphingolipids in Cell Death after Photodamage
    DUSKA M SEPAROVIC; Fiscal Year: 2010
    Sphingolipids in Cell Death after Photodamage Abstract The long-term objective of our research is to augment the efficacy of the cancer treatment photodynamic therapy (PDT)...
  48. Vascular smooth muscle apoptosis prevention by glucose
    Frank Brosius; Fiscal Year: 2004
    ..It is therefore not surprising that modulation of these processes affects cell death pathways...
  49. Vascular smooth muscle apoptosis prevention by glucose
    Frank Brosius; Fiscal Year: 2003
    ..It is therefore not surprising that modulation of these processes affects cell death pathways...
  50. Vascular smooth muscle apoptosis prevention by glucose
    Frank Brosius; Fiscal Year: 2002
    ..It is therefore not surprising that modulation of these processes affects cell death pathways...
  51. Vascular smooth muscle apoptosis prevention by glucose
    Frank Brosius; Fiscal Year: 2005
    ..It is therefore not surprising that modulation of these processes affects cell death pathways...
  52. Sphingolipids in Cell Death after Photodamage
    Duska Separovic; Fiscal Year: 2009
    Sphingolipids in Cell Death after Photodamage Abstract The long-term objective of our research is to augment the efficacy of the cancer treatment photodynamic therapy (PDT)...
  53. ICE FAMILY AND NEURONAL CELL DEATH
    Junying Yuan; Fiscal Year: 1999
    ..In the nematode C. elegans the gene ced -3 is essential for cells to undergo programmed cell death. Interleukin-1b converting enzyme (ICE) has been identified as a vertebrate homologue of Ced-3...
  54. Children's Responses to Sibling Death in NICU/PICU in 3 Racial/Ethnic Groups
    JOANNE M contact YOUNGBLUT; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Death of a sibling is a double loss for surviving siblings - loss of a playmate, confidante, friend, role model - and loss of parents whose grief leaves them with little to no emotional energy to ..
  55. PSYCHOSOCIAL FACTORS IN SUDDEN CARDIAC DEATH
    Sue Thomas; Fiscal Year: 2000
    This proposal "Psychosocial Factor Outcome Study in Sudden Cardiac Death (PFOS)" constitutes an independent project complimentary to the ongoing NIH clinical trial, "Sudden Cardiac Death Heart Failure Trial (SCD-HeFT)...
  56. PSYCHOSOCIAL FACTORS IN SUDDEN CARDIAC DEATH
    Sue Thomas; Fiscal Year: 2001
    This proposal "Psychosocial Factor Outcome Study in Sudden Cardiac Death (PFOS)" constitutes an independent project complimentary to the ongoing NIH clinical trial, "Sudden Cardiac Death Heart Failure Trial (SCD-HeFT)...
  57. Connexins in Ischemia-Induced Neuronal Death
    Michael Bennett; Fiscal Year: 2003
    ..The molecular mechanisms underlying this pattern of neuronal death are not well understood...
  58. Delayed Rectifier K Channel Biogenesis is Unveiled in Models of Long QT Syndrome
    BRIAN DELISLE; Fiscal Year: 2009
    Every year, sudden cardiac death claims up to 25,000 people that do not have structural heart disease...
  59. Connexins in Ischemia-Induced Neuronal Death
    Michael Bennett; Fiscal Year: 2006
    ..The molecular mechanisms underlying this pattern of neuronal death are not well understood...
  60. PSYCHOSOCIAL FACTORS IN SUDDEN CARDIAC DEATH
    Sue Thomas; Fiscal Year: 2002
    This proposal "Psychosocial Factor Outcome Study in Sudden Cardiac Death (PFOS)" constitutes an independent project complimentary to the ongoing NIH clinical trial, "Sudden Cardiac Death Heart Failure Trial (SCD-HeFT)...
  61. Connexins in Ischemia-Induced Neuronal Death
    Michael Bennett; Fiscal Year: 2007
    ..The molecular mechanisms underlying this pattern of neuronal death are not well understood...
  62. Delayed Rectifier K Channel Biogenesis is Unveiled in Models of Long QT Syndrome
    BRIAN DELISLE; Fiscal Year: 2009
    Every year, sudden cardiac death claims up to 25,000 people that do not have structural heart disease...
  63. CYTOMEGALOVIRUS DNA REPLICATION AND INVERSION
    ANITA LOUISE MCCORMICK; Fiscal Year: 2010
    ..Programmed cell death (PCD), sensor-triggered interferon activation, and signaling cascades are all affected starting at early times ..
  64. Multi-Modal Lysosomotropic Death Therapy for Malignant Peripheral Nerve Sheath Tu
    KEVIN AARON ROTH; Fiscal Year: 2010
    ..We have been investigating the cell death promoting activities of chloroquine (CQ), a lysosomotropic agent, for almost ten years and have found that CQ ..
  65. Multi-Modal Lysosomotropic Death Therapy for Malignant Peripheral Nerve Sheath Tu
    Kevin Roth; Fiscal Year: 2009
    ..We have been investigating the cell death promoting activities of chloroquine (CQ), a lysosomotropic agent, for almost ten years and have found that CQ ..
  66. CYTOMEGALOVIRUS DNA REPLICATION AND INVERSION
    ANITA MCCORMICK; Fiscal Year: 2009
    ..Programmed cell death (PCD), sensor-triggered interferon activation, and signaling cascades are all affected starting at early times ..
  67. Omega-3 Fatty Acids and Risk of Sudden Cardiac Death in Hemodialysis Patients
    ALLON NIR FRIEDMAN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Though sudden cardiac death is the single leading cause of mortality in dialysis patients, no effective or practical treatment presently exists...
  68. Red Blood Cell Omega-3 Fatty Acids and Coronary Artery Disease
    Luc Djousse; Fiscal Year: 2009
    ..Some observational studies and randomized trials have suggested that n-3 FA may lower the risk of sudden cardiac death (SCD) and coronary events, possibly through antiarrhythmic effects...
  69. Red Blood Cell Omega-3 Fatty Acids and Coronary Artery Disease
    Luc Djousse; Fiscal Year: 2010
    ..Some observational studies and randomized trials have suggested that n-3 FA may lower the risk of sudden cardiac death (SCD) and coronary events, possibly through antiarrhythmic effects...
  70. Nuclear Function of Abl in DNA Damage Response
    Jean Wang; Fiscal Year: 2009
    ..Persistent damage to the genomic DNA can activate programmed cell death. Therefore, fundamental understanding of genotoxin-induced cell death mechanisms holds the promise of enhancing ..
  71. Regulation of Cell Death Activation
    Ding Xue; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): As a normal aspect of animal development and homeostasis, programmed cell death (apoptosis) plays an essential role in maintaining the physiological balance of appropriate cell numbers by opposing ..
  72. Nuclear Function of Abl in DNA Damage Response
    Jean Y J Wang; Fiscal Year: 2010
    ..Persistent damage to the genomic DNA can activate programmed cell death. Therefore, fundamental understanding of genotoxin-induced cell death mechanisms holds the promise of enhancing ..
  73. Genes That Regulate Neuronal Cell Death
    Robert Freeman; Fiscal Year: 2009
    Cell death is widespread during the development of the nervous system where it helps to ensure that the proper number and types of connections are formed between neurons and their targets...
  74. ANALYSIS OF DROSOPHILA Hsp27 IN DEVELOPMENTALLY REGULATED APOPTOSIS
    Jonathan S Minden; Fiscal Year: 2010
    ..Developmentally regulated cell death is a complex and dynamic process, with many input signals and many downstream cellular responses...
  75. Non-apoptotic cell death pathways in response to metabolic stress and chemotherap
    Wei Xing Zong; Fiscal Year: 2009
    ..such as DNA alkylating agents remain the most effective means of treating cancer patients by inducing cancer cell death. This suggests that alternative cell death pathways may be involved...
  76. Non-apoptotic cell death pathways in response to metabolic stress and chemotherap
    Wei Xing Zong; Fiscal Year: 2010
    ..such as DNA alkylating agents remain the most effective means of treating cancer patients by inducing cancer cell death. This suggests that alternative cell death pathways may be involved...
  77. INTRACELLULAR MECHANISMS OF CELL DEATH FOLLOWING TBI
    Ramesh Raghupathi; Fiscal Year: 2000
    Traumatic brain injury (TBI) is a significant cause of death in individuals under the age of 45 in the United States and survivors are faced with chronic brain damage leading to debilitating behavioral dysfunction...
  78. Cardiac Myocyte Apoptosis: Mechanism and Significance
    RICHARD KITSIS; Fiscal Year: 2009
    Prolonged ischemia with or without reperfusion triggers the apoptotic and non-apoptotic death of cardiac myocytes. The death of these cells is a major component in the pathogenesis of myocardial infarction...
  79. Cardiac Myocyte Apoptosis: Mechanism and Significance
    Richard N Kitsis; Fiscal Year: 2010
    Prolonged ischemia with or without reperfusion triggers the apoptotic and non-apoptotic death of cardiac myocytes. The death of these cells is a major component in the pathogenesis of myocardial infarction...
  80. GENETIC ANALYSIS OF HYPOXIC DEATH IN C ELEGANS
    C Michael Crowder; Fiscal Year: 2009
    Hypoxic cell death in the form of stroke and myocardial infarction is the largest single cause of death in the United States. The fundamental molecular mechanisms of hypoxic cell death are incompletely understood...
  81. Autophagy in epidermal melanocyte: a protective or a destructive role?
    Vijayasaradhi Setaluri; Fiscal Year: 2012
    ..Disruption of melanocyte homeostasis leads to skin disorders. Most notably, loss due to death of melanocyte causes depigmentary disorder vitiligo and accompanying skin photosensitivity, and gain of ..
  82. Determinants of Disease Expression in Arrhythmogenic Cardiomyopathy
    Jeffrey Saffitz; Fiscal Year: 2009
    ..heart muscle disorder characterized by a high incidence of serious ventricular tachyarrhythmias and sudden cardiac death, typically preceding the development of contractile dysfunction and cardiac remodeling1, 2...
  83. NONSUSTAINED VENTRICULAR TACHYCARDIA
    Alfred Buxton; Fiscal Year: 1991
    Coronary artery disease is the most common cause of death in the United States today, and half of the deaths in patients with coronary disease occur suddenly...
  84. Prolyl Hydroxylation and Neuronal Cell Death
    Robert S Freeman; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Neuronal death is a highly regulated event that occurs throughout the developing nervous system...
  85. p53-Independent Cell Death Signaling by Mitomycin DNA Adducts
    Jill Bargonetti; Fiscal Year: 2009
    The need to identify drugs and pathways that induce cell death independently of p53 deserves substantial attention...
  86. Prolyl Hydroxylation and Neuronal Cell Death
    Robert Freeman; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Neuronal death is a highly regulated event that occurs throughout the developing nervous system...
  87. Prolyl Hydroxylation and Neuronal Cell Death
    Robert Freeman; Fiscal Year: 2009
    Cell death is widespread during the development of the nervous system, where it helps to ensure that the proper number and types of connections are formed between neurons and their targets...
  88. Regulated cell death during biofilm development
    Kenneth Bayles; Fiscal Year: 2009
    ..been extensively studied in the context of cell growth, but the molecular details by which bacteria undergo cell death and lysis have remained a near complete mystery...
  89. Sudden Cardiac Death in Heart Failure Trial 10 year Follow-up (SCD-HeFT 10 yr.)
    Gust Bardy; Fiscal Year: 2009
    ..and focuses on Comparative Effectiveness Research in a prior NHLBI sponsored clinical trial (The Sudden Cardiac Death in Heart Failure Trial, SCD-HeFT, UO1s HL55297, HL55496, HL55766)...
  90. A Novel Cell Death Pathway Induced by Galectin-1
    Linda Baum; Fiscal Year: 2002
    Cell death is a critical regulatory process in development, in homeostasis, and in disease. Many cell death triggers have been identified, although little is known about many of the molecular pathways that lead to cell death...
  91. A Novel Cell Death Pathway Induced by Galectin-1
    Linda Baum; Fiscal Year: 2003
    Cell death is a critical regulatory process in development, in homeostasis, and in disease. Many cell death triggers have been identified, although little is known about many of the molecular pathways that lead to cell death...
  92. A Novel Cell Death Pathway Induced by Galectin-1
    Linda Baum; Fiscal Year: 2004
    Cell death is a critical regulatory process in development, in homeostasis, and in disease. Many cell death triggers have been identified, although little is known about many of the molecular pathways that lead to cell death...
  93. A Novel Cell Death Pathway Induced by Galectin-1
    Linda Baum; Fiscal Year: 2001
    Cell death is a critical regulatory process in development, in homeostasis, and in disease. Many cell death triggers have been identified, although little is known about many of the molecular pathways that lead to cell death...