Genomes and Genes
Summary: Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.
Publications272 found, 100 shown here
- Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell diseaseGregory J Kato
Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Dr, MSC 1476, Bldg 10CRC, Rm 5 5140, Bethesda, MD 20892, USA
Blood 107:2279-85. 2006..was associated with a clinical subphenotype of pulmonary hypertension, leg ulceration, priapism, and risk of death in patients with sickle cell disease...
- Cardiovascular death and nonfatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting are predicted by residual platelet reactivity to ADP detected by a point-of-care assay: a 12-month follow-upRossella Marcucci
Department of Medical and Surgical Critical Care and Center for Study at Molecular and Clinical Level of Chronic, Degenerative and Neoplastic Diseases to Develop Novel Therapies, University of Florence, Florence, Italy
Circulation 119:237-42. 2009....
- Irresistible bouquet of death--how are burying beetles (Coleoptera: Silphidae: Nicrophorus) attracted by carcassesB Kalinová
Infochemicals Group, Institute of Organic Chemistry and Biochemistry v v i, Academy of Sciences of the Czech Republic, Flemingovo nam 2, 166 10, Prague 6, Czech Republic
Naturwissenschaften 96:889-99. 2009..Chemical analysis showed that immediately after death, emitted volatiles did not differ from those emitted by a living organism...
- Aortic arch plaques and risk of recurrent stroke and deathMarco R Di Tullio
Division of Cardiology, Department of Medicine, Columbia University, College of Physicians and Surgeons, 630 W 168th St, New York, NY 10032, USA
Circulation 119:2376-82. 2009..Aortic arch plaques are a risk factor for ischemic stroke. Although the stroke mechanism is conceivably thromboembolic, no randomized studies have evaluated the efficacy of antithrombotic therapies in preventing recurrent events...
- Pediatric heart transplantation after declaration of cardiocirculatory deathMark M Boucek
Department of Pediatrics, Joe DiMaggio Children s Hospital, Hollywood, FL 33021, USA
N Engl J Med 359:709-14. 2008..The mean age of donors was 3.7 days, and the mean time to death after withdrawal from life support was 18.3 minutes...
- Protein kinase Cepsilon makes the life and death decisionAlakananda Basu
Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Cell Signal 19:1633-42. 2007..is caused by dysregulation in cellular signaling systems that control cell proliferation, differentiation and cell death. Protein kinase C (PKC), a family of serine/threonine kinases, plays an important role in the growth factor signal ..
- Serum neutrophil gelatinase-associated lipocalin as a predictor of organ recovery from delayed graft function after kidney transplantation from donors after cardiac deathMamoru Kusaka
Dept of Urol, Div of Molecular Genetics, Inst for Comp Med Sci and 21st Century COE Program, Dev Center for Targeted and Minimally Invasive Diagnosis and Treatment, Fujita Health University School of Medicine, Japan
Cell Transplant 17:129-34. 2008Because of a worldwide shortage of renal grafts, kidneys procured from donors after cardiac death (DCD) have recently become an important source of renal transplants...
- Pilot study on traumatic grief treatment program for Japanese women bereaved by violent deathNozomu Asukai
Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
J Trauma Stress 24:470-3. 2011..Based on Jacobson's Reliable Change Index, 46% showed change on all 3 measures. These findings suggest that our treatment model may be feasible for treating traumatic grief with PTSD in non-Western settings...
- Distributions of observed death tolls govern sensitivity to human fatalitiesChristopher Y Olivola
Department of Cognitive, Perceptual, and Brain Sciences, University College London, London WC1H 0AP, United Kingdom
Proc Natl Acad Sci U S A 106:22151-6. 2009..the loss of human lives depends largely on the extent to which we are moved by the size of their associated death tolls...
- Good death inventory: a measure for evaluating good death from the bereaved family member's perspectiveMitsunori Miyashita
Department of Adult Nursing Palliative Care Nursing, School of Health Sciences and Nursing, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
J Pain Symptom Manage 35:486-98. 2008The aim of this study was to develop a measure for evaluating good death from the bereaved family member's perspective, and to examine the validity and reliability of the assessment...
- Death toll exceeded 70,000 in Europe during the summer of 2003Jean Marie Robine
INSERM, Demographie et Sante, CRLC, Centre Val d Aurelle, Parc Euromedecine, 34298 Montpellier Cedex 5, France
C R Biol 331:171-8. 2008..Centralizing the count of daily deaths on an operational geographical scale constitutes a priority for Public Health in Europe...
- Hemolytic uremic syndrome and death in persons with Escherichia coli O157:H7 infection, foodborne diseases active surveillance network sites, 2000-2006L Hannah Gould
Enteric Diseases Epidemiology Branch, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Clin Infect Dis 49:1480-5. 2009..We evaluated the age-specific rate of HUS and death among persons with STEC O157 infection and the risk factors associated with developing HUS.
- Parental death during childhood and adult cardiovascular risk in a developing country: the Guangzhou Biobank Cohort StudyC Mary Schooling
Department of Community Medicine, School of Public Health, The University of Hong Kong, Hong Kong SAR, China
PLoS ONE 6:e19675. 2011..We examined the association of a potential marker of childhood emotional adversity with cardiovascular disease risk factors in a developing country...
- Study of recent and future trends in place of death in Belgium using death certificate data: a shift from hospitals to care homesDirk Houttekier
Vrije Universiteit Brussel, End of Life Care Research Group Ghent University and Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
BMC Public Health 11:228. 2011Since most patients prefer out-of-hospital death, place of death can be considered an indicator of end-of-life care quality...
- A palliative-care intervention and death at home: a cluster randomised trialM S Jordhøy
Unit of Applied Clinical Research, Norwegian University of Science and Technology, Kreftbygget, University Hospital of Trondheim
Lancet 356:888-93. 2000..We did a cluster randomised trial to assess the intervention's effectiveness compared with conventional care..
- Place of death in metropolitan regions: metropolitan versus non-metropolitan variation in place of death in Belgium, The Netherlands and EnglandDirk Houttekier
End of Life Care Research Group, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
Health Place 16:132-9. 2010Place of death is an important societal indicator of end-of-life quality for the terminally ill...
- Decapitation in rats: latency to unconsciousness and the 'wave of death'Clementina M Van Rijn
Department of Biological Psychology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
PLoS ONE 6:e16514. 2011..massive wave which can be recorded approximately one minute after decapitation reflects the ultimate border between life and death. This observation might have implications in the discussions on the appropriate time for organ donation.
- Surges of electroencephalogram activity at the time of death: a case seriesLakhmir S Chawla
Department of Critical Care Medicine and Anesthesiology, George Washington University Medical Center, Washington, DC 20037, USA
J Palliat Med 12:1095-100. 2009..in electrical activity occurred when there was no discernable blood pressure, patients who suffer "near death" experiences may be recalling the aggregate memory of the synaptic activity associated with this terminal but ..
- Long-term evolution of 5S ribosomal DNA seems to be driven by birth-and-death processes and selection in Ensis razor shells (Mollusca: Bivalvia)Joaquín Vierna
Department of Molecular and Cell Biology, Evolutionary Biology Group GIBE, Universidade da Coruna, A Zapateira s n, La Coruña 15071, Spain
Biochem Genet 47:635-44. 2009..These results strongly suggest that the long-term evolution of Ensis 5S ribosomal DNA is driven by birth-and-death processes and selection.
- Psychiatric morbidity, violent crime, and suicide among children and adolescents exposed to parental deathHolly C Wilcox
Johns Hopkins University, Baltimore, MD 21287 3325, USA
J Am Acad Child Adolesc Psychiatry 49:514-23; quiz 530. 2010..This retrospective cohort study examined the risk for suicide, psychiatric hospitalization, and violent criminal convictions among offspring of parents who died from suicide, accidents, and other causes...
- New insights on brain stem death: from bedside to benchJulie Y H Chan
Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81346, Taiwan, ROC
Prog Neurobiol 77:396-425. 2005As much as brain stem death is currently the clinical definition of death in many countries and is a phenomenon of paramount medical importance, there is a dearth of information on its mechanistic underpinnings...
- The boundaries of organ donation after circulatory deathJames L Bernat
Dartmouth Medical School, Hanover, NH, USA
N Engl J Med 359:669-71. 2008
- Donating hearts after cardiac death--reversing the irreversibleRobert M Veatch
Kennedy Institute of Ethics, Georgetown University, Washington, DC, USA
N Engl J Med 359:672-3. 2008
- ASTS recommended practice guidelines for controlled donation after cardiac death organ procurement and transplantationD J Reich
Drexel University College of Medicine, Philadelphia, PA, USA
Am J Transplant 9:2004-11. 2009..Controlled donation after cardiac death (DCD) offers the family and the patient with a hopeless prognosis the option to donate when brain death criteria ..
- Epidemiological pathology of dementia: attributable-risks at death in the Medical Research Council Cognitive Function and Ageing StudyFiona E Matthews
Medical Research Council MRC Biostatistics, University of Cambridge, Cambridge, United Kingdom
PLoS Med 6:e1000180. 2009..We report the attributable risks (ARs) for dementia at death for common age-related degenerative and vascular pathologies, and other factors, in the MRC Cognitive Function and ..
- A longitudinal study of the effects of age and time to death on hospital costsMeena Seshamani
University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Health Econ 23:217-35. 2004Recent studies indicate that approaching death, rather than age, may be the main demographic driver of health care costs...
- Death or hospitalization of patients on chronic hemodialysis is associated with a physician-based diagnosis of depressionS Susan Hedayati
Division of Nephrology, Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Kidney Int 74:930-6. 2008..Using time to event (death or hospitalization) models of analysis the hazard ratios were 2.11 and 2...
- The ethics of creating and responding to doubts about death criteriaJames M DuBois
Saint Louis University, 221 N Grand Blvd, St Louis, MO 63103, USA
J Med Philos 35:365-80. 2010Expressing doubts about death criteria can serve healthy purposes, but can also cause a number of harms, including decreased organ donation rates and distress for donor families and health care staff...
- The thin flat line: redefining who is legally dead in organ donation after cardiac deathMaxine M Harrington
Texas Wesleyan University School of Law, USA
Issues Law Med 25:95-143. 2009The debate over whether donation after cardiac death (DCD) donors are truly dead is not new but has surfaced mostly in the academic community...
- Changing pattern of organ donation at a single center: are potential brain dead donors being lost to donation after cardiac death?R F Saidi
Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Am J Transplant 10:2536-40. 2010Donation after cardiac death (DCD) has proven effective at increasing the availability of organs for transplantation...
- The impact of ischemic cholangiopathy in liver transplantation using donors after cardiac death: the untold storyAnton I Skaro
Division of Organ Transplantation, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Surgery 146:543-52; discussion 552-3. 2009Liver transplantation (LT) from donation after cardiac death (DCD) donors is increasingly being used to address organ shortages. Despite encouraging reports, standard survival metrics have overestimated the effectiveness of DCD livers...
- Death and conceptionG Bahadur
Department of Obstetrics and Gynaecology, Fertility and Reproductive Medicine Laboratories, Royal Free and University College Medical School, London, UK
Hum Reprod 17:2769-75. 2002..This may be achieved by offering ample time for informed and support counselling. Finally, consideration should be expressed for the welfare of unborn child, in a balanced, pragmatic and sensible manner...
- Survey of pediatricians' opinions on donation after cardiac death: are the donors dead?Ari R Joffe
Department of Pediatrics, University of Alberta and Stollery Children s Hospital, Edmonton, Alberta, Canada
Pediatrics 122:e967-74. 2008There has been debate in the ethics literature as to whether the donation-after-cardiac-death donor is dead after 5 minutes of absent circulation...
- Excess weight at time of presentation of myocardial infarction is associated with lower initial mortality risks but higher long-term risks including recurrent re-infarction and cardiac deathAnil Nigam
Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
Int J Cardiol 110:153-9. 2006..01). CONCLUSIONS: Following AMI, overweight and obese individuals although paradoxically protected from short-term death have a long-term mortality risk that is similar to normal weight individuals...
- Using students' journals about death experiences as a pedagological toolKevin Doll
Department of Human Development and Family Studies, University of Wisconsin Stout, Menomie, WI, USA
Gerontol Geriatr Educ 29:124-38. 2008The purpose of this article is to evaluate a pedagological tool for student's study of death and bereavement...
- The prevalence of PTSD following the violent death of a child and predictors of change 5 years laterShirley A Murphy
Department of Psychosocial and Community Health, School of Nursing, University of Washington, Seattle, Washington 98195 7263, USA
J Trauma Stress 16:17-25. 2003In this study, we examined the violent death bereavement trajectories of 173 parents by following them prospectively for 5 years after their children's deaths by accident, suicide, homicide, or undetermined causes...
- Place of death: correlations with quality of life of patients with cancer and predictors of bereaved caregivers' mental healthAlexi A Wright
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
J Clin Oncol 28:4457-64. 2010To determine whether the place of death for patients with cancer is associated with patients' quality of life (QoL) at the end of life (EOL) and psychiatric disorders in bereaved caregivers.
- Line-of-duty death: psychological treatment of traumatic bereavement in law enforcementLaurence Miller
Int J Emerg Ment Health 9:13-23. 2007A line-of-duty death (LODD) strikingly brings home the risk and vulnerability of all law enforcement officers and affects the officer's peers, the entire department, the wider police community, and the officer's family...
- Non-heart beating organ donation: old procurement strategy--new ethical problemsM D D Bell
Intensive Care, The General Infirmary at Leeds, Great George Street, Leeds LS1 3EX, UK
J Med Ethics 29:176-81. 2003..on necessity, the process may constitute a desirable outcome for patient and family when progression to brain stem death (BSD) does not occur and conventional organ retrieval from the beating heart donor is thereby prevented...
- Peritoneal cooling may provide improved protection for uncontrolled donors after cardiac death: an exploratory porcine studyA P Navarro
Liver, Renal and Pancreatic Transplant Unit, Freeman Hospital, Newcastle upon Tyne, UK
Am J Transplant 9:1317-23. 2009Uncontrolled donation after cardiac death (DCD) renal transplantation relies on rapid establishment of organ preservation interventions...
- Factors influencing place of death in GermanyLuis Carlos Escobar Pinzón
Institute of Occupational, Social and Environmental Medicine, University Medical Center of Johannes Gutenberg University of Mainz, Mainz, Germany
J Pain Symptom Manage 41:893-903. 2011Knowledge about factors influencing the place of death may be very useful for the planning of public health strategies to improve the situation of terminally ill patients.
- Using livers from donation after cardiac death donors--a proposal to protect the true Achilles heelJohn J Fung
Liver Transpl 13:1633-6. 2007
- Donation after cardiac death: a survey of university student opinions on death and donationAri R Joffe
Department of Pediatrics, 3A3 Stollery Children s Hospital, University of Alberta, 8440 112 Street, Edmonton, AB, T6G 2B7, Canada
Intensive Care Med 35:240-7. 2009To determine if university students consider the donation after cardiac death donor as dead.
- What is a natural cause of death? A survey of how coroners in England and Wales approach borderline casesI S Roberts
Department of Pathological Sciences, University of Manchester, UK
J Clin Pathol 53:367-73. 2000..There are no guidelines to help doctors in dealing with such cases and death certification is often arbitrary and inconsistent...
- Inability to obtain deferred consent due to early death in emergency research: effect on validity of clinical trial resultsTim C Jansen
Department of Intensive Care, Erasmus MC University Medical Center, CA, Rotterdam, The Netherlands
Intensive Care Med 36:1962-5. 2010..To illustrate the impact on the validity of trial results due to excluding patients from a randomized controlled trial for whom no deferred consent could be obtained after randomization because study procedures had already been finished...
- Factors influencing death at home in terminally ill patients with cancer: systematic reviewBarbara Gomes
The Cicely Saunders Foundation Department of Palliative Care, Policy, and Rehabilitation, King s College London, London SE5 9RJ
BMJ 332:515-21. 2006To determine the relative influence of different factors on place of death in patients with cancer.
- Ethical controversies at end of life after traumatic brain injury: defining death and organ donationMichael Souter
Department of Anesthesiology and Pain Medicine and Neurosurgery, Harborview Medical Center, University of Washington, Seattle, WA, USA
Crit Care Med 38:S502-9. 2010b>Death is more than a mere biological occurrence. It has important legal, medical, and social ramifications that make it imperative that those who are responsible for determination of death be accurate and above suspicion...
- Liver transplantation following donation after cardiac death: an analysis using matched pairsJames K Pine
Department of Hepatobiliary Transplant Surgery, St James s University Hospital, Beckett Street, United Kingdom
Liver Transpl 15:1072-82. 2009Grafts from donation after cardiac death (DCD) donors are used to increase the number of organs available for liver transplantation. There is concern that warm ischemia may impair graft function...
- Current situation of donation after circulatory death in European countriesBeatriz Dominguez-Gil
Organizacion Nacional de Trasplantes, Madrid, Spain
Transpl Int 24:676-86. 2011The aim of the present study was to describe the current situation of donation after circulatory death (DCD) in the Council of Europe, through a dedicated survey...
- The dead donor rule: can it withstand critical scrutiny?Franklin G Miller
National Institutes of Health, Bethesda, MD 20892 1156, USA
J Med Philos 35:299-312. 2010..rationale for the DDR by rejecting the underlying premise that it is necessarily wrong for physicians to cause the death of patients and the claim that abandoning this rule would exploit vulnerable patients...
- Grief shortly after suicide and natural death: a comparative study among spouses and first-degree relativesM H de Groot
Department of Social Psychiatry at the University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
Suicide Life Threat Behav 36:418-31. 2006..the felt need for professional help was higher among the former, even after adjustment for expectedness of death, sociodemographic differences, and relatives'/spouses' neuroticism...
- Organ donation after cardiac death: legal and ethical justifications for antemortem interventionsBernadette Richards
Law School, University of Adelaide, Adelaide, SA, Australia
Med J Aust 187:168-70. 2007Organ donation after cardiac death increases organ availability, but raises several legal and ethical issues, including consent...
- The accuracy of histological assessments of dental development and age at deathT M Smith
Department of Anthropology, Stony Brook University, USA
J Anat 208:125-38. 2006..Using known-period incremental features, the crown formation time and age at death of five pig-tailed macaques (Macaca nemestrina) were estimated with standard histological techniques and compared ..
- Machine perfusion as a tool to select kidneys recovered from uncontrolled donors after cardiac deathO N Reznik
St Petersburg State Research Institute for Emergency named after I I Dzhanelidze, Saint Petersburg, Russia
Transplant Proc 40:1023-6. 2008The use of kidneys from uncontrolled donors after cardiac death (uDCD) remains disputable due to significant warm ischemia time (WIT) causing ischemia-reperfusion injuries...
- Talking about death with children who have severe malignant diseaseUlrika Kreicbergs
Division of Clinical Cancer Epidemiology, Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden
N Engl J Med 351:1175-86. 2004..by the parents of a child who is terminally ill with a malignant disease is whether or not they should talk about death with their child...
- Maternal breast cancer risk after the death of a childMats Lambe
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Int J Cancer 110:763-6. 2004The possible association between a severe traumatic life event (death of a child) and breast cancer risk was examined in a case-control study nested within a nation-wide cohort in Sweden...
- Risk factors for graft survival after liver transplantation from donation after cardiac death donors: an analysis of OPTN/UNOS dataR Mateo
Department of Surgery, Division of Transplantation, Keck USC School of Medicine, Los Angeles, California, USA
Am J Transplant 6:791-6. 2006Due to increasing use of allografts from donation after cardiac death (DCD) donors, we evaluated DCD liver transplants and impact of recipient and donor factors on graft survival...
- Death and dying from old people's point of view. A literature reviewIngalill Rahm Hallberg
The Swedish Institute for Health Sciences, Lund University, Lund, Sweden
Aging Clin Exp Res 16:87-103. 2004..This calls for an understanding of older people's view of death and dying, and one way forward is to investigate the current knowledge base...
- Determinants of the place of death in the Brussels metropolitan regionDirk Houttekier
End of Life Care Research Group, Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels 1090, Belgium
J Pain Symptom Manage 37:996-1005. 2009The place where people die is not only considered an indicator of quality of death, but also has implications for health care costs and the organization of end-of-life care...
- A statistical analogy between collapse of solids and death of living organisms: proposal for a 'law of life'Nicola M Pugno
Department of Structural Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy
Med Hypotheses 69:441-7. 2007..collapse of solids and living organisms; in particular we deduce a statistical law governing their probability of death. We have derived such a law coupling the widely used Weibull Statistics, developed for describing the distribution ..
- Near-death experience in a boy undergoing uneventful elective surgery under general anesthesiaUrsula Lopez
Division of Anesthesiology, University Hospital of Geneva, Geneva, Switzerland
Paediatr Anaesth 16:85-8. 2006Near-death experience (NDE) is a complex subjective experience, which may include affective elements such as a sense of peacefulness, paranormal components such as a sensation of floating out of the body, and a perception of being in a ..
- Controlled non-heart beating organ donation: neither the whole solution nor a step too farP Murphy
The General Infirmary, Leeds, UK
Anaesthesia 63:526-30. 2008..care pathway in order to allow donation to take place, and, finally, an uncertainty over how soon after cardiac death organ retrieval can begin...
- Does the addition of functional status indicators to case-mix adjustment indices improve prediction of hospitalization, institutionalization, and death in the elderly?Nancy E Mayo
Medicine and Clinical Epidemiology, McGill University, Montreal, Quebec, Canada
Med Care 43:1194-202. 2005..One type of information that is highly valued but has so far not been captured by administrative health databases is functional status indicators (FSI)...
- Where older people die: a retrospective population-based studyS Ahmad
University Department of Geriatric Medicine, Academic Centre, Llandough Hospital, Penarth, UK
QJM 98:865-70. 2005..Palliative medicine services have invested in the community to support people dying at home. To develop end-of-life care for older people, we need to know where they die...
- Prescribing in palliative care as death approachesDavid C Currow
Department of Palliative and Supportive Services, Flinders University, Bedford Park, South Australia, Australia
J Am Geriatr Soc 55:590-5. 2007..To determine how prescribing for comorbid illnesses and symptom control changes during the palliative phase of a terminal illness...
- Donation after cardiac death in the US: history and usePeter L Abt
Division of Solid Organ Transplantation, Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA
J Am Coll Surg 203:208-25. 2006
- Risk of myocardial infarction and death associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) among healthy individuals: a nationwide cohort studyE L Fosbøl
Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark
Clin Pharmacol Ther 85:190-7. 2009..Using a historical cohort design, we estimated the risk of death and myocardial infarction associated with the use of NSAIDs...
- Organ donation after cardiac death: legal and ethical justifications for antemortem interventionsJames Tibballs
Med J Aust 188:186-7; author reply 188. 2008
- Interval between palliative care referral and death among patients treated at a comprehensive cancer centerWen-Wu Cheng
Shanghai Cancer Hospital, Fudan University, China
J Palliat Med 8:1025-32. 2005..The purpose of this retrospective study was to investigate the interval between palliative care referral and death in patients with advanced cancer...
- Impact of a pediatric donation after cardiac death programKristine M Pleacher
Department of Pediatrics, Division of Pediatric Critical Care, University of Utah, Salt Lake City, UT, USA
Pediatr Crit Care Med 10:166-70. 2009To determine the impact of a pediatric donation after cardiac death (DCD) program on organ donation.
- Prediction of cardiac death in hemodialysis patients by myocardial fatty acid imagingMasato Nishimura
Cardiovascular Division, Toujinkai Hospital, Kyoto, Japan
J Am Coll Cardiol 51:139-45. 2008The aim was to evaluate the potential of single-photon emission computed tomography (SPECT) to predict cardiac death in chronic hemodialysis patients using the iodinated fatty acid analogue iodine-123 123I-beta-methyl iodophenyl-..
- Beta-blockers reduce the risk of early death in ischemic strokeTomasz Dziedzic
Department of Neurology, Jagiellonian University, Botaniczna 3, 31 503 Krakow, Poland
J Neurol Sci 252:53-6. 2007..Experimental studies suggest that beta-blockers have also neuroprotective properties. The aim of this study was to assess if use of beta-blockers is associated with reduced risk of early death in ischemic stroke patients.
- A dual-process model of defense against conscious and unconscious death-related thoughts: an extension of terror management theoryT Pyszczynski
Department of Psychology, University of Colorado at Colorado Springs 80933 7150, USA
Psychol Rev 106:835-45. 1999Distinct defensive processes are activated by conscious and nonconscious but accessible thoughts of death. Proximal defenses, which entail suppressing death-related thoughts or pushing the problem of death into the distant future by ..
- Evaluation of emergency medicine resident death notification skills by direct observationRonald S Benenson
Department of Emergency Medicine, York Hospital, York, PA 17405, USA
Acad Emerg Med 10:219-23. 2003Emergency physicians commonly perform death notifications. Physician training in death notification has been limited. Resident physicians are rarely evaluated in their performance of death notifications.
- Islet transplantation using donors after cardiac death: report of the Japan Islet Transplantation RegistryTakuro Saito
Japanese Islet Transplant Registry, Fukushima Medical University, Fukushima City, Fukushima, Japan
Transplantation 90:740-7. 2010This report summarizes outcomes of islet transplantation employing donors after cardiac death (DCD) between 2004 and 2007 as reported to the Japan Islet Transplantation Registry.
- Extracorporeal support: improves donor renal graft function after cardiac deathA Rojas-Pena
General Surgery Department, Division of Transplantation, University of Michigan Health System, Ann Arbor, MI, USA
Am J Transplant 10:1365-74. 2010Donors after cardiac death (DCD) could increase the organ pool. Data supports good long-term renal graft survival. However, DCDs are <10% of deceased donors in the United States, due to delayed graft function, and primary nonfunction...
- Factors associated with congruence between preferred and actual place of deathChristina L Bell
Department of Geriatric Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
J Pain Symptom Manage 39:591-604. 2010Congruence between preferred and actual place of death may be an essential component in terminal care. Most patients prefer a home death, but many patients do not die in their preferred location...
- The natural history of renal disease in Australian Aborigines. Part 2. Albuminuria predicts natural death and renal failureW E Hoy
Menzies School of Health Research, Darwin, Northern Territory, Australia
Kidney Int 60:249-56. 2001..of this study was to describe the relationship of albuminuria and glomerular filtration rate (GFR) with natural death and renal failure in an Australian Aboriginal community with high rates of renal disease...
- Current status of donation after cardiac death liver transplantationDavid J Reich
Division of Multiorgan Transplantation and Hepatobiliary Surgery, Department of Surgery, Drexel University College of Medicine, Hahnemann University Hospital, Philadelphia, Pennsylvania 19102, USA
Curr Opin Organ Transplant 15:316-21. 2010The article reviews the current state of liver transplantation using allografts from donation after cardiac death (DCD), focusing on single and multicenter outcomes, best practice guidelines and emerging strategies to optimize ..
- Disability occurrence and proximity to deathBart Klijs
Department of Public Health, Erasmus MC, Rotterdam, The Netherlands
Disabil Rehabil 32:1733-41. 2010This paper aims to assess whether disability occurrence is related more strongly to proximity to death than to age.
- Processed electroencephalogram during donation after cardiac deathDavid B Auyong
Department of Anesthesiology, Virginia Mason Medical Center, Seattle, WA 98101, USA
Anesth Analg 110:1428-32. 2010We present a case series of increased bispectral index values during donation after cardiac death (DCD)...
- One hour hypothermic oxygenated perfusion (HOPE) protects nonviable liver allografts donated after cardiac deathOlivier de Rougemont
Department of Surgery, Swiss Hepato Pancreatico Biliary Center, University Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
Ann Surg 250:674-83. 2009..To test, in a large animal model, the efficacy of machine perfusion to rescue livers after prolonged ischemic injury...
- Long-term harm of low preparedness for a wife's death from cancer--a population-based study of widowers 4-5 years after the lossArna Hauksdóttir
Division of Clinical Cancer Epidemiology, Department of Oncology Pathology, Karolinska Institutet, Z5 U1 Karolinska Hospital, 17176 Stockholm, Sweden
Am J Epidemiol 172:389-96. 2010The authors examined the impact of a widower's preparedness before his wife's death from cancer on his risk of long-term morbidity...
- The logic for a conception-to-death cohort studyWilliam Eaton
Department of Mental Hygiene, Johns Hopkins University, Baltimore, MD, USA
Ann Epidemiol 12:445-51. 2002This article proposes that the nation undertake a study of a cohort which will be followed from pregnancy to death- a research project that will require more than 100 years...
- Attachment styles and personality disorders: their connections to each other and to parental divorce, parental death, and perceptions of parental caregivingK A Brennan
Department of Psychology, State University of New York, Brockport 14420 2914, USA
J Pers 66:835-78. 1998..underlying structure, and how both kinds of variables relate to family background factors, including parental death, parental divorce, and current representations of childhood relationships with parents...
- The issue of death and dying: employing problem-based learning in nursing educationEsther Mok
Department of Nursing and Health Sciences, The Hong Kong Polytechnic University, Hong Kong
Nurse Educ Today 22:319-29. 2002..emotionally painful, distressing and sometimes threatening experience for nurses as the illness is incurable and death is imminent...
- Biliary complications after liver transplantation from donation after cardiac death donors: an analysis of risk factors and long-term outcomes from a single centerDavid P Foley
Division of Organ Transplantation, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, 53792, USA
Ann Surg 253:817-25. 2011This study evaluates the long-term outcomes, biliary complication rates, and risk factors for biliary complications after liver transplantation from "donation after cardiac death" (DCD) donors.
- Patient perceptions of an outpatient palliative care intervention: "It had been on my mind before, but I did not know how to start talking about death..."Michael W Rabow
Division of General Internal Medicine, University of California at San Francisco, San Francisco, California 94115, USA
J Pain Symptom Manage 26:1010-5. 2003..6%) would have wanted the intervention even earlier in the course of their illness. Seriously ill outpatients found palliative care acceptable and helpful, reporting increased satisfaction and decreased health care utilization...
- Cold machine perfusion versus static cold storage of kidneys donated after cardiac death: a UK multicenter randomized controlled trialC J E Watson
Department of Surgery, University of Cambridge, Addenbrooke s Hospital, Cambridge
Am J Transplant 10:1991-9. 2010One third of deceased donor kidneys for transplantation in the UK are donated following cardiac death (DCD). Such kidneys have a high rate of delayed graft function (DGF) following transplantation...
- Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamineY M Wang
Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Neuron 19:1285-96. 1997....
- The fate of laterally transferred genes: life in the fast lane to adaptation or deathWeilong Hao
Department of Biology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
Genome Res 16:636-43. 2006..Together, this implies that many of the lineage-specific insertions are lost quickly during evolution and that perhaps a few of the genes inserted by lateral transfer are niche specific...
- Abandon the dead donor rule or change the definition of death?Robert M Veatch
Kennedy Institute of Ethics, Georgetown University, Washington, DC, USA
Kennedy Inst Ethics J 14:261-76. 2004..Another strategy would be to further amend the definition of death to classify one or both groups as deceased, thus permitting procurement without violation of the dead donor rule...
- Impact of lung transplantation on site of death in cystic fibrosisDee Ford
Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
J Cyst Fibros 6:391-5. 2007..Cystic fibrosis (CF) remains a lethal condition where a palliative approach is often taken at the end of life. We wanted to evaluate how lung transplantation impacts end of life care in adult CF patients...
- Donation after cardiac death: the University of Wisconsin experience with liver transplantationDavid P Foley
Department of Surgery, Division of Transplantation, University of Florida, Gainesville, FL, USA
Ann Surg 242:724-31. 2005OBJECTIVE: To determine whether the outcomes of liver transplantation (LTx) from donation after cardiac death (DCD) donors are equivalent to those from donation after brain death (DBD) donors...
- Place of death: analysis of cancer deaths in part of North West EnglandAnthony C Gatrell
Institute for Health Research, Lancaster University, Lancaster LA1 4YT
J Public Health Med 25:53-8. 2003Relatively little work of a detailed geographical nature has been undertaken on the distribution of place of death. In particular, given evidence that most cancer patients would prefer to die at home there is a need to examine the extent ..
- Quality of dying in the ICU: ratings by family membersRichard A Mularski
Oregon Health and Science University and Portland Veterans Affairs Medical Center, Portland, OR, USA
Chest 128:280-7. 2005..To explore the quality of the dying experience and associations to higher quality ratings for people who died in an ICU...
- Pro/con ethics debate: when is dead really dead?Leslie Whetstine
Health Care Ethics Center, Duquesne University, Pittsburgh, PA 15282, USA
Crit Care 9:538-42. 2005Contemporary intensive care unit (ICU) medicine has complicated the issue of what constitutes death in a life support environment...
- Is organ procurement causing the death of patients?James M DuBois
Saint Louis University, USA
Issues Law Med 18:21-41. 2002This article offers a philosophical foundation for the Uniform Determination of Death Act as it first examines death per se, and then examines brain death and the non-heart beating donor criteria for determining death...
- The importance of being dead: non-heart-beating organ donationJerry Menikoff
Department of History and Philosophy of Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Issues Law Med 18:3-20. 2002..wait, after a person's heart stops beating, before concluding that the person meets the heart-lung criteria for death. This question has assumed new importance with attempts to remove transplantable organs from people declared dead ..
- Learning from the dyingSusan D Block
Division of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, USA
N Engl J Med 353:1313-5. 2005
- Discretionary death: conditions, dilemmas, and normative regulationNora Machado
The Netherlands Institute for Advanced Studies, Meijboomslaan 1, Wassenaar, The Netherlands, and Department of Sociology, University of Gothenburg, Sweden, Skanstullsgatan 25, Gothenburg, Sweden or
Death Stud 29:791-809. 2005The author examines a major shift in the conceptualization and practices relating to death and dying in Western and other societies with advanced medicine...
- Il-7 receptor signaling in lymphopoiesisMotonari Kondo; Fiscal Year: 2009..governed by IL-7? receptor signaling include initiation offcell proliferation, protection from apoptotic cell death, and the induction oflineage-speciifiicevents, such as gene rearangement in antiigen receptor loacdi...
- Combination drug treatment to inhibit multiple cell death pathways after TBIALAN FADEN; Fiscal Year: 2009This application entitled "Attenuation of Diverse Cell Death Pathways after Traumatic Brain Injury by Multi- drug Combination Therapy" addresses Broad Challenge Area (15): Translational Science and Specific Challenge Topic: 15-HD-104, ..
- Use of Beta-Lapachone for Lung Cancer ChemotherapyDavid Boothman; Fiscal Year: 2007Use of B-lapachone for non-small cell lung cancer (NSCLC) therapy Lung cancer is the leading cause of death by cancer in the U.S. Non-small cell lung cancer (NSCLC) comprises over 75% of lung cancers diagnosed...
- Use of Beta-Lapachone for Lung Cancer ChemotherapyDavid Boothman; Fiscal Year: 2007Use of B-lapachone for non-small cell lung cancer (NSCLC) therapy Lung cancer is the leading cause of death by cancer in the U.S. Non-small cell lung cancer (NSCLC) comprises over 75% of lung cancers diagnosed...
- Bilirubin oxidation and intracerebral hemorrhageJoseph Clark; Fiscal Year: 2006..Intracerebral hemorrhage (ICH) is a type of stroke caused by bleeding into the brain, resulting in significant death and disability...
- Prognostic Impact and Arrhythmic Potential of Peri-infarct Zone by Cardiac MRIRaymond Y Kwong; Fiscal Year: 2010The incidence of sudden cardiac death (SCD) after myocardial infarction (MI) has remained unchanged and is most significant in the first year after MI...
- Prognostic Impact and Arrhythmic Potential of Peri-infarct Zone by Cardiac MRIRaymond Kwong; Fiscal Year: 2009The incidence of sudden cardiac death (SCD) after myocardial infarction (MI) has remained unchanged and is most significant in the first year after MI...
- Rituximab Elicitation of Tumor Specific T-cell Responses in Lymphoma PatientsSteven Bernstein; Fiscal Year: 2009..Rituximab induced FL cell death is expected to result in the release of tumor antigens, for example antigens derived from the variable regions of ..
- Neonatal Long QT Syndrome and Sudden Infant DeathALFRED GEORGE; Fiscal Year: 2009Sudden death during the first year of life is a leading cause of infant mortality in developed countries...
- Neonatal Long QT Syndrome and Sudden Infant DeathAlfred L George; Fiscal Year: 2010Sudden death during the first year of life is a leading cause of infant mortality in developed countries...
- Neonatal Long QT Syndrome and Sudden Infant DeathALFRED GEORGE; Fiscal Year: 2007Sudden death during the first year of life is a leading cause of infant mortality in developed countries...
- Mechanisms and Modulation of Cell Death in Traumatic Brain InjuryALAN IRA FADEN; Fiscal Year: 2010..However, some of these studies indicate that improvements often reflect only a delay in cell death, which still occurs eventually without the classical apoptotic phenotype...
- Mechanisms and Modulation of Cell Death in Traumatic Brain InjuryALAN IRA FADEN; Fiscal Year: 2009..However, some of these studies indicate that improvements often reflect only a delay in cell death, which still occurs eventually without the classical apoptotic phenotype...
- Regulation of myocardial growth and death by GSK-3Junichi Sadoshima; Fiscal Year: 2010Glycogen synthase kinase-3 (GSK-3), a serine/threonine kinase, plays an important role in regulating growth and death of cardiomyocytes...
- TNF-alpha in cell death & neuroprotection in glaucomaGULGUN TEZEL; Fiscal Year: 2006..cause of worldwide blindness, neither the precise pathogenic mechanisms, which lead to retinal ganglion cell death in glaucoma, nor effective strategies for neuroprotection are known...
- The mitochondrial permeability transition and heart failureWilliam Craigen; Fiscal Year: 2007Mitochondria are central in both energy production and cellular death pathways, yet a variety of questions concerning structure-function relationships of mitochondria remain poorly understood...
- Characterization of autonomic dysfunction in Rett syndrome and other MECP2 disordJeffrey L Neul; Fiscal Year: 2010..have a number of autonomic abnormalities including bradycardia, apnea, and respiratory arrest resulting in death in the first three years of life...
- Vascular smooth muscle apoptosis prevention by glucoseFrank Brosius; Fiscal Year: 2005..It is therefore not surprising that modulation of these processes affects cell death pathways...
- Sphingolipids in Cell Death after PhotodamageDUSKA M SEPAROVIC; Fiscal Year: 2010Sphingolipids in Cell Death after Photodamage Abstract The long-term objective of our research is to augment the efficacy of the cancer treatment photodynamic therapy (PDT)...
- Children's Responses to Sibling Death in NICU/PICU in 3 Racial/Ethnic GroupsJOANNE M contact YOUNGBLUT; Fiscal Year: 2010b>Death of a sibling is a double loss for surviving siblings - loss of a playmate, confidante, friend, role model - and loss of parents whose grief leaves them with little to no emotional energy to reach out to their hurting surviving ..
- Connexins in Ischemia-Induced Neuronal DeathMichael Bennett; Fiscal Year: 2003..The molecular mechanisms underlying this pattern of neuronal death are not well understood...
- PSYCHOSOCIAL FACTORS IN SUDDEN CARDIAC DEATHSue Thomas; Fiscal Year: 2002This proposal "Psychosocial Factor Outcome Study in Sudden Cardiac Death (PFOS)" constitutes an independent project complimentary to the ongoing NIH clinical trial, "Sudden Cardiac Death Heart Failure Trial (SCD-HeFT)...
- Connexins in Ischemia-Induced Neuronal DeathMichael Bennett; Fiscal Year: 2006..The molecular mechanisms underlying this pattern of neuronal death are not well understood...
- Delayed Rectifier K Channel Biogenesis is Unveiled in Models of Long QT SyndromeBRIAN DELISLE; Fiscal Year: 2009Every year, sudden cardiac death claims up to 25,000 people that do not have structural heart disease...
- Connexins in Ischemia-Induced Neuronal DeathMichael Bennett; Fiscal Year: 2007..The molecular mechanisms underlying this pattern of neuronal death are not well understood...
- Multi-Modal Lysosomotropic Death Therapy for Malignant Peripheral Nerve Sheath TuKEVIN AARON ROTH; Fiscal Year: 2010..We have been investigating the cell death promoting activities of chloroquine (CQ), a lysosomotropic agent, for almost ten years and have found that CQ ..
- CYTOMEGALOVIRUS DNA REPLICATION AND INVERSIONANITA LOUISE MCCORMICK; Fiscal Year: 2010..Programmed cell death (PCD), sensor-triggered interferon activation, and signaling cascades are all affected starting at early times ..
- Nuclear Function of Abl in DNA Damage ResponseJean Wang; Fiscal Year: 2009..Persistent damage to the genomic DNA can activate programmed cell death. Therefore, fundamental understanding of genotoxin-induced cell death mechanisms holds the promise of enhancing ..
- Regulation of Cell Death ActivationDing Xue; Fiscal Year: 2010As a normal aspect of animal development and homeostasis, programmed cell death (apoptosis) plays an essential role in maintaining the physiological balance of appropriate cell numbers by opposing uncontrolled cell proliferation...
- Nuclear Function of Abl in DNA Damage ResponseJean Y J Wang; Fiscal Year: 2010..Persistent damage to the genomic DNA can activate programmed cell death. Therefore, fundamental understanding of genotoxin-induced cell death mechanisms holds the promise of enhancing ..
- Non-apoptotic cell death pathways in response to metabolic stress and chemotherapWei Xing Zong; Fiscal Year: 2010..such as DNA alkylating agents remain the most effective means of treating cancer patients by inducing cancer cell death. This suggests that alternative cell death pathways may be involved...
- Cardiac Myocyte Apoptosis: Mechanism and SignificanceRichard N Kitsis; Fiscal Year: 2010Prolonged ischemia with or without reperfusion triggers the apoptotic and non-apoptotic death of cardiac myocytes. The death of these cells is a major component in the pathogenesis of myocardial infarction...
- Prolyl Hydroxylation and Neuronal Cell DeathRobert S Freeman; Fiscal Year: 2010Neuronal death is a highly regulated event that occurs throughout the developing nervous system...
- Prolyl Hydroxylation and Neuronal Cell DeathRobert Freeman; Fiscal Year: 2009Cell death is widespread during the development of the nervous system, where it helps to ensure that the proper number and types of connections are formed between neurons and their targets...
- A Novel Cell Death Pathway Induced by Galectin-1Linda Baum; Fiscal Year: 2004Cell death is a critical regulatory process in development, in homeostasis, and in disease. Many cell death triggers have been identified, although little is known about many of the molecular pathways that lead to cell death...