death

Summary

Summary: Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.

Top Publications

  1. pmc Factors influencing death at home in terminally ill patients with cancer: systematic review
    Barbara Gomes
    The Cicely Saunders Foundation Department of Palliative Care, Policy, and Rehabilitation, King s College London, London SE5 9RJ
    BMJ 332:515-21. 2006
  2. ncbi A subset of circulating microRNAs are predictive for cardiac death after discharge for acute myocardial infarction
    Sen Matsumoto
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Biochem Biophys Res Commun 427:280-4. 2012
  3. ncbi Cardiovascular death and nonfatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting are predicted by residual platelet reactivity to ADP detected by a point-of-care assay: a 12-month follow-up
    Rossella Marcucci
    Department of Medical and Surgical Critical Care and Center for Study at Molecular and Clinical Level of Chronic, Degenerative and Neoplastic Diseases to Develop Novel Therapies, University of Florence, Florence, Italy
    Circulation 119:237-42. 2009
  4. pmc Place of death: correlations with quality of life of patients with cancer and predictors of bereaved caregivers' mental health
    Alexi A Wright
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Clin Oncol 28:4457-64. 2010
  5. pmc Birth and death of protein domains: a simple model of evolution explains power law behavior
    Georgy P Karev
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    BMC Evol Biol 2:18. 2002
  6. ncbi Reversal of the British trends in place of death: time series analysis 2004-2010
    Barbara Gomes
    King s College London, Cicely Saunders Institute, Department of Palliative Care, Policy and Rehabilitation, London, UK
    Palliat Med 26:102-7. 2012
  7. pmc Right ventricular structure is associated with the risk of heart failure and cardiovascular death: the Multi-Ethnic Study of Atherosclerosis (MESA)--right ventricle study
    Steven M Kawut
    Penn Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia
    Circulation 126:1681-8. 2012
  8. pmc Manganese superoxide dismutase: beyond life and death
    Aaron K Holley
    University of Kentucky, Lexington, USA
    Amino Acids 42:139-58. 2012
  9. ncbi Hemolytic uremic syndrome and death in persons with Escherichia coli O157:H7 infection, foodborne diseases active surveillance network sites, 2000-2006
    L Hannah Gould
    Enteric Diseases Epidemiology Branch, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Infect Dis 49:1480-5. 2009
  10. pmc The fate of laterally transferred genes: life in the fast lane to adaptation or death
    Weilong Hao
    Department of Biology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    Genome Res 16:636-43. 2006

Detail Information

Publications339 found, 100 shown here

  1. pmc Factors influencing death at home in terminally ill patients with cancer: systematic review
    Barbara Gomes
    The Cicely Saunders Foundation Department of Palliative Care, Policy, and Rehabilitation, King s College London, London SE5 9RJ
    BMJ 332:515-21. 2006
    To determine the relative influence of different factors on place of death in patients with cancer.
  2. ncbi A subset of circulating microRNAs are predictive for cardiac death after discharge for acute myocardial infarction
    Sen Matsumoto
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Biochem Biophys Res Commun 427:280-4. 2012
    ..667 miRs, 11 miRs were found to be differentially expressed in the serum among patients at high-risk for cardiac death. Real-time RT-PCR confirmed that the serum levels of miR-155 and miR-380* were approximately 4- and 3-fold higher, ..
  3. ncbi Cardiovascular death and nonfatal myocardial infarction in acute coronary syndrome patients receiving coronary stenting are predicted by residual platelet reactivity to ADP detected by a point-of-care assay: a 12-month follow-up
    Rossella Marcucci
    Department of Medical and Surgical Critical Care and Center for Study at Molecular and Clinical Level of Chronic, Degenerative and Neoplastic Diseases to Develop Novel Therapies, University of Florence, Florence, Italy
    Circulation 119:237-42. 2009
    ....
  4. pmc Place of death: correlations with quality of life of patients with cancer and predictors of bereaved caregivers' mental health
    Alexi A Wright
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Clin Oncol 28:4457-64. 2010
    To determine whether the place of death for patients with cancer is associated with patients' quality of life (QoL) at the end of life (EOL) and psychiatric disorders in bereaved caregivers.
  5. pmc Birth and death of protein domains: a simple model of evolution explains power law behavior
    Georgy P Karev
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    BMC Evol Biol 2:18. 2002
    ..Exploration of different types of evolutionary models in an attempt to determine which of them lead to power law distributions has the potential of revealing non-trivial aspects of genome evolution...
  6. ncbi Reversal of the British trends in place of death: time series analysis 2004-2010
    Barbara Gomes
    King s College London, Cicely Saunders Institute, Department of Palliative Care, Policy and Rehabilitation, London, UK
    Palliat Med 26:102-7. 2012
    ..Secular trends towards an institutionalised dying have been reported in Britain and other developed world regions...
  7. pmc Right ventricular structure is associated with the risk of heart failure and cardiovascular death: the Multi-Ethnic Study of Atherosclerosis (MESA)--right ventricle study
    Steven M Kawut
    Penn Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia
    Circulation 126:1681-8. 2012
    ..We examined the association of abnormal RV structure and function with the risk of heart failure or cardiovascular death in a population-based multiethnic sample free of clinical cardiovascular disease at baseline.
  8. pmc Manganese superoxide dismutase: beyond life and death
    Aaron K Holley
    University of Kentucky, Lexington, USA
    Amino Acids 42:139-58. 2012
    ..The results demonstrate the role of MnSOD beyond its essential role for survival and suggest a novel strategy for an antioxidant approach to cancer intervention...
  9. ncbi Hemolytic uremic syndrome and death in persons with Escherichia coli O157:H7 infection, foodborne diseases active surveillance network sites, 2000-2006
    L Hannah Gould
    Enteric Diseases Epidemiology Branch, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Infect Dis 49:1480-5. 2009
    ..We evaluated the age-specific rate of HUS and death among persons with STEC O157 infection and the risk factors associated with developing HUS.
  10. pmc The fate of laterally transferred genes: life in the fast lane to adaptation or death
    Weilong Hao
    Department of Biology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    Genome Res 16:636-43. 2006
    ..Together, this implies that many of the lineage-specific insertions are lost quickly during evolution and that perhaps a few of the genes inserted by lateral transfer are niche specific...
  11. ncbi Why do patients choose chemotherapy near the end of life? A review of the perspective of those facing death from cancer
    Robin Matsuyama
    Massey Cancer Center of Virginia Commonwealth University, Richmond, VA 23298 0230, USA
    J Clin Oncol 24:3490-6. 2006
    ..We sought to determine the available sources of knowledge, the choices, and concerns of actual patients, and how patients balanced competing issues...
  12. ncbi Kidney transplantation from donors after cardiac death: a 25-year experience
    Maarten G J Snoeijs
    Department of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands
    Transplantation 90:1106-12. 2010
    ..Donation after cardiac death (DCD) has been shown to increase the number of kidneys available for transplantation...
  13. ncbi Prediction of recurrent stroke and vascular death in patients with transient ischemic attack or nondisabling stroke: a prospective comparison of validated prognostic scores
    Christian Weimar
    Department of Neurology, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
    Stroke 41:487-93. 2010
    ..We aimed to prospectively compare the predictive accuracy of the Essen Stroke Risk Score, Stroke Prognostic Instrument, Hankey score, and the Life Long After Cerebral ischemia score...
  14. ncbi Awareness of general practitioners concerning cancer patients' preferences for place of death: evidence from four European countries
    Winne Ko
    Regional Palliative Care Network, IRCCS AOU San Martino IST, Genoa, Italy
    Eur J Cancer 49:1967-74. 2013
    ..healthcare systems and they supposedly have a role in supporting cancer patients in achieving their desired place of death. A four-country (Belgium, the Netherlands, Italy and Spain) study was carried out exploring current practices.
  15. pmc Smooth and cardiac muscle-selective knock-out of Kruppel-like factor 4 causes postnatal death and growth retardation
    Tadashi Yoshida
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    J Biol Chem 285:21175-84. 2010
    ..In vivo chromatin immunoprecipitation assays on the heart revealed that Klf4 bound to the promoter region of the Gata4 gene. Results provide novel evidence that Klf4 plays a key role in late fetal and/or postnatal cardiac development...
  16. pmc Study of recent and future trends in place of death in Belgium using death certificate data: a shift from hospitals to care homes
    Dirk Houttekier
    Vrije Universiteit Brussel, End of Life Care Research Group Ghent University and Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
    BMC Public Health 11:228. 2011
    Since most patients prefer out-of-hospital death, place of death can be considered an indicator of end-of-life care quality...
  17. ncbi Plasma asymmetric dimethylarginine predicts death and major adverse cardiovascular events in individuals referred for coronary angiography
    Tse Min Lu
    Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Int J Cardiol 153:135-40. 2011
    ..We assessed the prognostic value of plasma ADMA levels in 997 consecutive individuals referred for coronary angiography from July 2006 to June 2009...
  18. pmc Aortic arch plaques and risk of recurrent stroke and death
    Marco R Di Tullio
    Division of Cardiology, Department of Medicine, Columbia University, College of Physicians and Surgeons, 630 W 168th St, New York, NY 10032, USA
    Circulation 119:2376-82. 2009
    ..Aortic arch plaques are a risk factor for ischemic stroke. Although the stroke mechanism is conceivably thromboembolic, no randomized studies have evaluated the efficacy of antithrombotic therapies in preventing recurrent events...
  19. ncbi Irresistible bouquet of death--how are burying beetles (Coleoptera: Silphidae: Nicrophorus) attracted by carcasses
    B Kalinová
    Infochemicals Group, Institute of Organic Chemistry and Biochemistry v v i, Academy of Sciences of the Czech Republic, Flemingovo nam 2, 166 10, Prague 6, Czech Republic
    Naturwissenschaften 96:889-99. 2009
    ..Chemical analysis showed that immediately after death, emitted volatiles did not differ from those emitted by a living organism...
  20. ncbi The transformation of utilities for health states worse than death: consequences for the estimation of EQ-5D value sets
    Leida M Lamers
    Institute for Medical Technology Assessment Department of Health Policy and Management, Erasmus University Medical Center Rotterdam, The Netherlands
    Med Care 45:238-44. 2007
    Utilities for health are measured on an interval scale, where 1 refers to full health and 0 refers to death. No theoretical lower boundary on the utilities for states worse than death exists...
  21. ncbi Death toll exceeded 70,000 in Europe during the summer of 2003
    Jean Marie Robine
    INSERM, Demographie et Sante, CRLC, Centre Val d Aurelle, Parc Euromedecine, 34298 Montpellier Cedex 5, France
    C R Biol 331:171-8. 2008
    ..Centralizing the count of daily deaths on an operational geographical scale constitutes a priority for Public Health in Europe...
  22. ncbi Current situation of donation after circulatory death in European countries
    Beatriz Dominguez-Gil
    Organizacion Nacional de Trasplantes, Madrid, Spain
    Transpl Int 24:676-86. 2011
    The aim of the present study was to describe the current situation of donation after circulatory death (DCD) in the Council of Europe, through a dedicated survey...
  23. ncbi A longitudinal study of the effects of age and time to death on hospital costs
    Meena Seshamani
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Health Econ 23:217-35. 2004
    Recent studies indicate that approaching death, rather than age, may be the main demographic driver of health care costs...
  24. ncbi Pediatric heart transplantation after declaration of cardiocirculatory death
    Mark M Boucek
    Department of Pediatrics, Joe DiMaggio Children s Hospital, Hollywood, FL 33021, USA
    N Engl J Med 359:709-14. 2008
    ..The mean age of donors was 3.7 days, and the mean time to death after withdrawal from life support was 18.3 minutes...
  25. ncbi Nuclear roundness variance predicts prostate cancer progression, metastasis, and death: A prospective evaluation with up to 25 years of follow-up after radical prostatectomy
    Robert W Veltri
    James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Prostate 70:1333-9. 2010
    ..Therefore, we evaluated the prognostic value of nuclear roundness variance (NRV) for prostate cancer (PCa) progression, metastasis and PCa-specific death free survivals in a cohort of 116 men after radical prostatectomy (RP).
  26. ncbi Neurocognitive processes of linguistic cues related to death
    Shihui Han
    Department of Psychology, Peking University, Beijing, People s Republic of China
    Neuropsychologia 48:3436-42. 2010
    ..However, the neural substrates underlying the processing of death-related information remain unclear...
  27. ncbi Propensity for home death among Taiwanese cancer decedents in 2001-2006, determined by services received at end of life
    Siew Tzuh Tang
    Graduate School of Nursing, Chang Gung University, Tao Yuan, Taiwan
    J Pain Symptom Manage 40:566-74. 2010
    The discrepancy between patients' preferred and actual place of death highlights the dilemma inherent in achieving their preferences for home death...
  28. ncbi Time to death, airway wall inflammation and remodelling in fatal asthma
    A L James
    West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia
    Eur Respir J 26:429-34. 2005
    ..Airway smooth muscle contraction and the accumulation of luminal mucus may contribute to death from asthma and relate to time to death...
  29. ncbi Lung transplantation with donation after cardiac death donors: long-term follow-up in a single center
    Nilto C De Oliveira
    Department of Surgery, Division of Cardiothoracic Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wis, USA
    J Thorac Cardiovasc Surg 139:1306-15. 2010
    We sought to examine long-term outcomes at the University of Wisconsin for all lung transplant recipients who received lungs from donation after cardiac death donors since the initiation of this program in 1993.
  30. ncbi Dying, death, and medical education: student voices
    Cynthia M Williams
    Department of Family Medicine, Biostatistics Counsulting Center, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    J Palliat Med 8:372-81. 2005
    ..However, there is very little medical literature that directly addresses how medical students and residents are to behave, manage emotion, and confront their own grieving process when patients die...
  31. ncbi Controlling death: the false promise of advance directives
    Henry S Perkins
    Ecumenical Center for Religion and Health and Division of General Medicine, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Ann Intern Med 147:51-7. 2007
    ....
  32. pmc Long-term effects of the death of a child on parents' adjustment in midlife
    Catherine H Rogers
    Department of Psychology, Georgia State University, Atlanta, GA 30302 5010, USA
    J Fam Psychol 22:203-11. 2008
    The death of a child is a traumatic event that can have long-term effects on the lives of parents...
  33. pmc Deterioration, death and the evolution of reproductive restraint in late life
    John M McNamara
    Department of Mathematics, University of Bristol, University Walk, Bristol BS8 1TW, UK
    Proc Biol Sci 276:4061-6. 2009
    ..It also provides a unified account of not only standard life-history models but of related models involving the allocation of limited resources...
  34. pmc The Quality of Dying and Death Questionnaire (QODD): empirical domains and theoretical perspectives
    Lois Downey
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
    J Pain Symptom Manage 39:9-22. 2010
    ..in Missoula, Montana, to construct a model of latent-variable domains underlying the Quality of Dying and Death questionnaire (QODD)...
  35. ncbi Mortality in parents following the death of a child: a nationwide follow-up study from Sweden
    Mikael Rostila
    Centre for Health Equity Studies, Stockholm University, Stockholm, Sweden
    J Epidemiol Community Health 66:927-33. 2012
    The death of a young child is so devastating that it can increase the risk of mortality in the grieving parent. Little is known about the impact of an adult child's death on the health of parents.
  36. pmc Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people
    H Bruunsgaard
    Department of Infectious Diseases, H S, Rigshospitalet, University of Copenhagen, Glostrup University Hospital, Denmark
    Clin Exp Immunol 132:24-31. 2003
    ..and effects of the two cytokines were independent of each other as well as of other traditional risk factors for death [smoking, blood pressure, physical exercise, total cholesterol, co-morbidity, body mass index (BMI) and intake of ..
  37. ncbi Near-death states reported in a sample of 50 misusers
    Ornella Corazza
    Department of Clinical Pharmacology, University of Hertfordshire, Pharmacy and Postgraduate Medical Schools, Hatfield, Herts, UK
    Subst Use Misuse 45:916-24. 2010
    ..We aimed here at assessing, in a sample of ketamine misusers, concordance between the typical near-death experience (NDE) features and the on-drug psychoactive effects the subjects experienced...
  38. ncbi A retrospective analysis of preferred and actual place of death for hospice patients
    Laura Holdsworth
    University of Kent, UK
    Int J Palliat Nurs 16:424, 426, 428 passim. 2010
    The purpose of this study was to explore recording rates of preferences, and the preferred and actual place of death among hospice patients. Data was collected retrospectively from a group of three hospices over a 6-month period...
  39. ncbi The vortex: families' experiences with death in the intensive care unit
    Karin T Kirchhoff
    University of Utah College of Nursing, Salt Lake City, USA
    Am J Crit Care 11:200-9. 2002
    Lack of communication from healthcare providers contributes to the anxiety and distress reported by patients' families after a patient's death in the intensive care unit.
  40. pmc LACE+ index: extension of a validated index to predict early death or urgent readmission after hospital discharge using administrative data
    Carl van Walraven
    Ottawa Hospital Research Institute, Administrative Services Building, Room 1003, 1053 Carling Avenue, Ottawa, ON K1Y 4E9, Canada
    Open Med 6:e80-90. 2012
    b>Death or urgent readmission after hospital discharge is a common adverse event that can be used to compare outcomes of care between institutions...
  41. ncbi Variability in the determination of death after cardiac arrest: a review of guidelines and statements
    Sonny Dhanani
    Pediatric Critical Care, Children s Hospital of Eastern Ontario, Faculty of Medicine, University of Ottawa, Canada
    J Intensive Care Med 27:238-52. 2012
    The reemergence of organ donation after circulatory determination of death (DCDD) in Canada demands the establishment of clear, evidence-based guidelines for the determination of death...
  42. ncbi Randomized trial of short-course high-dose erythropoietin in donation after cardiac death kidney transplant recipients
    Z Aydin
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Transplant 12:1793-800. 2012
    ..single center study with high-dose recombinant human erythropoietin-β (Epoetin) in 92 donation after cardiac death (DCD) kidney transplant recipients. Patients were randomized to receive an intravenous bolus of Epoetin (3...
  43. ncbi Novel approaches to expanding the lung donor pool: donation after cardiac death and ex vivo conditioning
    Marcelo Cypel
    Division Thoracic Surgery, Toronto Lung Transplant Program, Toronto General Hospital, University of Toronto, Toronto, M5G 2C4, Canada
    Clin Chest Med 32:233-44. 2011
    ..In the first approach, lungs from donation after cardiac death (DCD) donors are used to increase the quantity of organ donors...
  44. pmc Do good health and material circumstances protect older people from the increased risk of death after bereavement?
    Sunil M Shah
    Division of Population Health Sciences and Education, St George s University of London, London, UK
    Am J Epidemiol 176:689-98. 2012
    An increased risk of death in persons who have suffered spousal bereavement has been described in many populations. The impact of modifying factors, such as chronic disease and material circumstances, is less well understood...
  45. ncbi A palliative-care intervention and death at home: a cluster randomised trial
    M S Jordhøy
    Unit of Applied Clinical Research, Norwegian University of Science and Technology, Kreftbygget, University Hospital of Trondheim
    Lancet 356:888-93. 2000
    ..We did a cluster randomised trial to assess the intervention's effectiveness compared with conventional care..
  46. pmc Impact of normothermic preservation with extracellular type solution containing trehalose on rat kidney grafting from a cardiac death donor
    Satomi Iwai
    Laboratory of Small Animal Surgery I, School of Veterinary Medicine, Kitasato University, Aomori, Japan
    PLoS ONE 7:e33157. 2012
    The aim of this study was to investigate factors that may improve the condition of a marginal kidney preserved with a normothermic solution following cardiac death (CD) in a model of rat kidney transplantation (RTx).
  47. ncbi Place of death and hospital care for children who died of cancer in England, 1999-2006
    Anjali Shah
    Childhood Cancer Research Group, Richards Building, University of Oxford, Old Road Campus, Headington, Oxford OX3 7LG, UK
    Eur J Cancer 47:2175-81. 2011
    To describe patterns of hospital care and to evaluate factors influencing place of death for children who died after a diagnosis of cancer in England during 1999-2006.
  48. ncbi Combined use of high-sensitivity ST2 and NTproBNP to improve the prediction of death in heart failure
    Antoni Bayes-Genis
    Heart Failure Unit, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
    Eur J Heart Fail 14:32-8. 2012
    To address the incremental usefulness of biomarkers from different disease pathways for predicting risk of death in heart failure (HF).
  49. pmc Existential neuroscience: neurophysiological correlates of proximal defenses against death-related thoughts
    Johannes Klackl
    Department of Psychology, University of Salzburg, Salzburg, Austria
    Soc Cogn Affect Neurosci 8:333-40. 2013
    ..and worldview defense, presumably in order to deal with the potential for anxiety that roots in the knowledge that death is inevitable...
  50. ncbi Donation after circulatory death: burying the dead donor rule
    David Rodríguez-Arias
    Universidad del Pais Vasco EHU
    Am J Bioeth 11:36-43. 2011
    ..regarding the vital status of both brain-dead donors and individuals who undergo donation after circulatory death (DCD), respecting the dead donor rule (DDR) remains the standard moral framework for organ procurement...
  51. pmc Transfusion of older stored blood and risk of death: a meta-analysis
    Dong Wang
    Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland 20892, USA
    Transfusion 52:1184-95. 2012
    ..Older blood develops lesions and accumulates potentially injurious substances. Some studies report increasing toxicity as blood ages. We assessed the safety of transfused older versus newer stored blood...
  52. pmc Death and seeking alternative therapy largely accounted for lost to follow-up of patients on ART in northwest Ethiopia: a community tracking survey
    Mamo Wubshet
    Institute of Public Health, University of Gondar, Gondar, Ethiopia
    PLoS ONE 8:e59197. 2013
    ..Tracking patients lost to follow-up and understanding their status is essential to maintain program quality and to develop targeted interventions to prevent LTF. We aimed to determine the outcome and factors associated with LTF...
  53. ncbi Involvement of palliative care services strongly predicts place of death in Belgium
    Dirk Houttekier
    End of Life Care Research Group, Ghent University, Brussels, Belgium
    J Palliat Med 13:1461-8. 2010
    Place of death is considered a quality indicator of end-of-life care and enabling people to die where they choose is an important aspiration of palliative care...
  54. ncbi Between life and death: women's experiences of coming close to death, and surviving a severe postpartum haemorrhage and emergency hysterectomy
    Rakime Elmir
    Family and Community Health Research Group FaCH, School of Nursing and Midwifery, University of Western Sydney, Sydney, Penrith South DC, NSW 1797, Australia
    Midwifery 28:228-35. 2012
    ..to describe women's experiences of having an emergency hysterectomy following a severe postpartum haemorrhage...
  55. ncbi A primatological perspective on death
    James R Anderson
    Department of Psychology, University of Stirling, Scotland
    Am J Primatol 73:410-4. 2011
    ..It is argued that particular attention should be paid to how the context of a death affects individuals, for example, traumatic accidental or predation-induced death versus peaceful death following ..
  56. pmc Existential neuroscience: a functional magnetic resonance imaging investigation of neural responses to reminders of one's mortality
    Markus Quirin
    Department of Psychology, Universitat Osnabruck, Seminarstrasse 20, 49069 Osnabruck, Germany
    Soc Cogn Affect Neurosci 7:193-8. 2012
    ..However, extant research has yet to examine the neurological correlates of cognitions about one's inevitable death. The present study thus investigated in 17 male participants patterns of neural activation elicited by mortality ..
  57. ncbi "Death" and the valuation of health-related quality of life
    S Macran
    Center for Health Economics, University of York, Helsington, York, United Kingdom
    Med Care 39:217-27. 2001
    ....
  58. ncbi Stroke in parents who lost a child: a nationwide follow-up study in Denmark
    Jiong Li
    Danish Epidemiology Science Centre, Department of Epidemiology and Social Medicine, University of Aarhus, Aarhus, Denmark
    Neuroepidemiology 22:211-6. 2003
    ..We therefore examined whether or not one of the most extreme psychological stressors, the death of a child, was associated with the risk of stroke in a nationwide population-based follow-up study...
  59. ncbi Review: the quality of dying and death: a systematic review of measures
    Sarah Hales
    Psychosocial Oncology and Palliative Care, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada
    Palliat Med 24:127-44. 2010
    ..To determine whether modern medicine is facilitating 'good' deaths, appropriate measures of the quality of dying and death must be developed and utilized...
  60. ncbi There is nothing paranormal about near-death experiences: how neuroscience can explain seeing bright lights, meeting the dead, or being convinced you are one of them
    Dean Mobbs
    Medical Research Council, Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, CB2 7EF, UK
    Trends Cogn Sci 15:447-9. 2011
    Approximately 3% of Americans declare to have had a near-death experience...
  61. ncbi Death or hospitalization of patients on chronic hemodialysis is associated with a physician-based diagnosis of depression
    S Susan Hedayati
    Division of Nephrology, Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Kidney Int 74:930-6. 2008
    ..Using time to event (death or hospitalization) models of analysis the hazard ratios were 2.11 and 2...
  62. ncbi Ischemic cholangiopathy following liver transplantation from donation after cardiac death donors
    Edie Y Chan
    Division of Transplantation, Department of Surgery, University of Washington, Seattle, WA 98195, USA
    Liver Transpl 14:604-10. 2008
    The use of donation after cardiac death (DCD) donor hepatic allografts is becoming more widespread; however, there have been published reports of increased graft failure from specific complications associated with this type of allograft...
  63. ncbi The effect of normothermic recirculation before cold preservation on post-transplant injury of ischemically damaged donor kidneys
    Cyril Moers
    Surgery Research Laboratory, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Transpl Int 25:210-7. 2012
    Kidneys recovered from donation after cardiac death (DCD) are increasingly used to enlarge the deceased donor pool...
  64. pmc Discordance between living and death assemblages as evidence for anthropogenic ecological change
    Susan M Kidwell
    Department of Geophysical Sciences, University of Chicago, 5734 South Ellis Avenue, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 104:17701-6. 2007
    Mismatches between the composition of a time-averaged death assemblage (dead remains sieved from the upper mixed-zone of the sedimentary column) and the local living community are typically attributed to natural postmortem processes...
  65. ncbi Nurses' experiences with hospice patients who refuse food and fluids to hasten death
    Linda Ganzini
    Department of Veterans Affairs, Oregon Health and Science University, Portland, Oreg, USA
    N Engl J Med 349:359-65. 2003
    Voluntary refusal of food and fluids has been proposed as an alternative to physician-assisted suicide for terminally ill patients who wish to hasten death. There are few reports of patients who have made this choice.
  66. ncbi Increased risk of severe recurrence of hepatitis C virus in liver transplant recipients of donation after cardiac death allografts
    Roberto Hernandez-Alejandro
    Multi Organ Transplant Program, London Health Sciences Centre, University Hospital, London, ON, Canada
    Transplantation 92:686-9. 2011
    In hepatitis C virus (HCV) recipients of donation after cardiac death (DCD) grafts, there is suggestion of lower rates of graft survival, indicating that DCD grafts themselves may represent a significant risk factor for severe recurrence ..
  67. ncbi DSCAM deficiency causes loss of pre-inspiratory neuron synchroneity and perinatal death
    Kenji Amano
    Laboratory for Neurogenetics, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    J Neurosci 29:2984-96. 2009
    ..These results suggest that DSCAM plays a critical role in central respiratory regulation in a dosage-dependent manner...
  68. ncbi Phenomenology of near-death experiences: a cross-cultural perspective
    John Belanti
    Broadmeadows Adult Community Mental Health, Broadmeadows VIC 3407, Australia
    Transcult Psychiatry 45:121-33. 2008
    Near-death experiences (NDEs) include a set of subjective experiences encountered by people who were close to death or were faced with life-threatening situations...
  69. ncbi Predictors of place of death for seniors in Ontario: a population-based cohort analysis
    Sanober S Motiwala
    Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada
    Can J Aging 25:363-71. 2006
    Place of death was determined for all 58,689 seniors (age > or = 66 years) in Ontario who died during fiscal year 2001/2002...
  70. ncbi Does the arousal system contribute to near death experience?
    Kevin R Nelson
    Department of Neurology, University of Kentucky, Lexington, KY, USA
    Neurology 66:1003-9. 2006
    The neurophysiologic basis of near death experience (NDE) is unknown. Clinical observations suggest that REM state intrusion contributes to NDE...
  71. ncbi Anxiety and depression in parents 4-9 years after the loss of a child owing to a malignancy: a population-based follow-up
    Ulrika Kreicbergs
    Clinical Cancer Epidemiology, Department of Oncology and Pathology, Karolinska Institutet Z6 01, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    Psychol Med 34:1431-41. 2004
    Some consider the loss of a child as the most stressful life event. When the death is caused by a malignancy, the parents are commonly exposed not only to their own loss, but also to the protracted physical and emotional suffering of the ..
  72. ncbi Factors influencing place of death in Germany
    Luis Carlos Escobar Pinzón
    Institute of Occupational, Social and Environmental Medicine, University Medical Center of Johannes Gutenberg University of Mainz, Mainz, Germany
    J Pain Symptom Manage 41:893-903. 2011
    Knowledge about factors influencing the place of death may be very useful for the planning of public health strategies to improve the situation of terminally ill patients.
  73. ncbi New insights on brain stem death: from bedside to bench
    Julie Y H Chan
    Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81346, Taiwan, ROC
    Prog Neurobiol 77:396-425. 2005
    As much as brain stem death is currently the clinical definition of death in many countries and is a phenomenon of paramount medical importance, there is a dearth of information on its mechanistic underpinnings...
  74. ncbi Excess weight at time of presentation of myocardial infarction is associated with lower initial mortality risks but higher long-term risks including recurrent re-infarction and cardiac death
    Anil Nigam
    Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Int J Cardiol 110:153-9. 2006
    ..To evaluate the influence of elevated body mass index (BMI) on short- and long-term survival following acute myocardial infarction (AMI)...
  75. pmc Protein kinase Cepsilon makes the life and death decision
    Alakananda Basu
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Cell Signal 19:1633-42. 2007
    ..is caused by dysregulation in cellular signaling systems that control cell proliferation, differentiation and cell death. Protein kinase C (PKC), a family of serine/threonine kinases, plays an important role in the growth factor signal ..
  76. pmc Epidemiological pathology of dementia: attributable-risks at death in the Medical Research Council Cognitive Function and Ageing Study
    Fiona E Matthews
    Medical Research Council MRC Biostatistics, University of Cambridge, Cambridge, United Kingdom
    PLoS Med 6:e1000180. 2009
    ..We report the attributable risks (ARs) for dementia at death for common age-related degenerative and vascular pathologies, and other factors, in the MRC Cognitive Function and ..
  77. ncbi Liver transplantation using Donation after Cardiac Death donors
    Diethard Monbaliu
    Catholic University Leuven, Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium
    J Hepatol 56:474-85. 2012
    ..All countries have strived to expand donor numbers beyond the standard Donation after Brain Death (DBD)...
  78. pmc Inability to obtain deferred consent due to early death in emergency research: effect on validity of clinical trial results
    Tim C Jansen
    Department of Intensive Care, Erasmus MC University Medical Center, CA, Rotterdam, The Netherlands
    Intensive Care Med 36:1962-5. 2010
    ..To illustrate the impact on the validity of trial results due to excluding patients from a randomized controlled trial for whom no deferred consent could be obtained after randomization because study procedures had already been finished...
  79. ncbi Serum neutrophil gelatinase-associated lipocalin as a predictor of organ recovery from delayed graft function after kidney transplantation from donors after cardiac death
    Mamoru Kusaka
    Dept of Urol, Div of Molecular Genetics, Inst for Comp Med Sci and 21st Century COE Program, Dev Center for Targeted and Minimally Invasive Diagnosis and Treatment, Fujita Health University School of Medicine, Japan
    Cell Transplant 17:129-34. 2008
    Because of a worldwide shortage of renal grafts, kidneys procured from donors after cardiac death (DCD) have recently become an important source of renal transplants...
  80. pmc Decapitation in rats: latency to unconsciousness and the 'wave of death'
    Clementina M Van Rijn
    Department of Biological Psychology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
    PLoS ONE 6:e16514. 2011
    ..massive wave which can be recorded approximately one minute after decapitation reflects the ultimate border between life and death. This observation might have implications in the discussions on the appropriate time for organ donation.
  81. ncbi Pilot study on traumatic grief treatment program for Japanese women bereaved by violent death
    Nozomu Asukai
    Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
    J Trauma Stress 24:470-3. 2011
    ..Based on Jacobson's Reliable Change Index, 46% showed change on all 3 measures. These findings suggest that our treatment model may be feasible for treating traumatic grief with PTSD in non-Western settings...
  82. pmc Distributions of observed death tolls govern sensitivity to human fatalities
    Christopher Y Olivola
    Department of Cognitive, Perceptual, and Brain Sciences, University College London, London WC1H 0AP, United Kingdom
    Proc Natl Acad Sci U S A 106:22151-6. 2009
    ..the loss of human lives depends largely on the extent to which we are moved by the size of their associated death tolls...
  83. ncbi Good death inventory: a measure for evaluating good death from the bereaved family member's perspective
    Mitsunori Miyashita
    Department of Adult Nursing Palliative Care Nursing, School of Health Sciences and Nursing, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Pain Symptom Manage 35:486-98. 2008
    The aim of this study was to develop a measure for evaluating good death from the bereaved family member's perspective, and to examine the validity and reliability of the assessment...
  84. pmc Parental death during childhood and adult cardiovascular risk in a developing country: the Guangzhou Biobank Cohort Study
    C Mary Schooling
    Department of Community Medicine, School of Public Health, The University of Hong Kong, Hong Kong SAR, China
    PLoS ONE 6:e19675. 2011
    ..We examined the association of a potential marker of childhood emotional adversity with cardiovascular disease risk factors in a developing country...
  85. ncbi Surges of electroencephalogram activity at the time of death: a case series
    Lakhmir S Chawla
    Department of Critical Care Medicine and Anesthesiology, George Washington University Medical Center, Washington, DC 20037, USA
    J Palliat Med 12:1095-100. 2009
    ..increase in electrical activity occurred when there was no discernable blood pressure, patients who suffer "near death" experiences may be recalling the aggregate memory of the synaptic activity associated with this terminal but ..
  86. ncbi Psychiatric morbidity, violent crime, and suicide among children and adolescents exposed to parental death
    Holly C Wilcox
    Johns Hopkins University, Baltimore, MD 21287 3325, USA
    J Am Acad Child Adolesc Psychiatry 49:514-23; quiz 530. 2010
    ..This retrospective cohort study examined the risk for suicide, psychiatric hospitalization, and violent criminal convictions among offspring of parents who died from suicide, accidents, and other causes...
  87. ncbi Long-term evolution of 5S ribosomal DNA seems to be driven by birth-and-death processes and selection in Ensis razor shells (Mollusca: Bivalvia)
    Joaquín Vierna
    Department of Molecular and Cell Biology, Evolutionary Biology Group GIBE, Universidade da Coruna, A Zapateira s n, La Coruña 15071, Spain
    Biochem Genet 47:635-44. 2009
    ..These results strongly suggest that the long-term evolution of Ensis 5S ribosomal DNA is driven by birth-and-death processes and selection.
  88. ncbi The last 3 months of life: care, transitions and the place of death of older people
    Marianne Klinkenberg
    Department of Palliative Care, Comprehensive Cancer Centre, Amsterdam, The Netherlands
    Health Soc Care Community 13:420-30. 2005
    ..Little is known about the factors associated with place of death. The aim of the present study was to investigate the care received by older people in the last 3 months of their ..
  89. pmc Factors associated with congruence between preferred and actual place of death
    Christina L Bell
    Department of Geriatric Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
    J Pain Symptom Manage 39:591-604. 2010
    Congruence between preferred and actual place of death may be an essential component in terminal care. Most patients prefer a home death, but many patients do not die in their preferred location...
  90. ncbi Place of death in metropolitan regions: metropolitan versus non-metropolitan variation in place of death in Belgium, The Netherlands and England
    Dirk Houttekier
    End of Life Care Research Group, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
    Health Place 16:132-9. 2010
    Place of death is an important societal indicator of end-of-life quality for the terminally ill...
  91. ncbi Determinants of the place of death in the Brussels metropolitan region
    Dirk Houttekier
    End of Life Care Research Group, Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels 1090, Belgium
    J Pain Symptom Manage 37:996-1005. 2009
    The place where people die is not only considered an indicator of quality of death, but also has implications for health care costs and the organization of end-of-life care...
  92. ncbi Talking about death with children who have severe malignant disease
    Ulrika Kreicbergs
    Division of Clinical Cancer Epidemiology, Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden
    N Engl J Med 351:1175-86. 2004
    One of the questions faced by the parents of a child who is terminally ill with a malignant disease is whether or not they should talk about death with their child.
  93. pmc Actual and preferred place of death of cancer patients. Results from the Italian survey of the dying of cancer (ISDOC)
    Monica Beccaro
    Unit of Clinical Epidemiology, National Cancer Institute, Largo Rosanna Benzi, 10, 16132, Genoa, Italy
    J Epidemiol Community Health 60:412-6. 2006
    To describe actual and preferred place of death of Italian cancer patients and to analyse the preferences met regarding the place of death.
  94. pmc Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease
    Gregory J Kato
    Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Dr, MSC 1476, Bldg 10CRC, Rm 5 5140, Bethesda, MD 20892, USA
    Blood 107:2279-85. 2006
    ..was associated with a clinical subphenotype of pulmonary hypertension, leg ulceration, priapism, and risk of death in patients with sickle cell disease...
  95. ncbi Near-death experiences in cardiac arrest survivors
    Christopher C French
    Anomalistic Psychology Research Unit, Department of Psychology, Goldsmiths College, University of London, New Cross, London SE14 6NW, UK
    Prog Brain Res 150:351-67. 2005
    Near-death experiences (NDEs) have become the focus of much interest in the last 30 years or so. Such experiences can occur both when individuals are objectively near to death and also when they simply believe themselves to be...
  96. ncbi A measure of the quality of dying and death. Initial validation using after-death interviews with family members
    J Randall Curtis
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Pain Symptom Manage 24:17-31. 2002
    ..To describe the validity of an instrument assessing the quality of dying and death using the perspective of family members after death and to identify clinical correlates of a high quality death, a ..
  97. ncbi Near-death experiences and the temporal lobe
    Willoughby B Britton
    Department of Psychology, University of Arizona, Tucson, AZ 85721, USA
    Psychol Sci 15:254-8. 2004
    ..We investigated temporal lobe functioning in individuals who reported having transcendental "near-death experiences" during life-threatening events...
  98. ncbi Extracorporeal support for organ donation after cardiac death effectively expands the donor pool
    Joseph F Magliocca
    Department of Surgery, The University of Wisconsin School of Medicine, Madison WI, USA
    J Trauma 58:1095-101; discussion 1101-2. 2005
    ..normothermic, extracorporeal perfusion (ECMO) for donation of abdominal organs for transplantation after cardiac death (DCD)...
  99. ncbi Incidence and correlates of near-death experiences in a cardiac care unit
    Bruce Greyson
    Department of Psychiatric Medicine, University of Virginia Health System, Charlottesville, VA, USA
    Gen Hosp Psychiatry 25:269-76. 2003
    Near-death experiences, unusual experiences during a close brush with death, may precipitate pervasive attitudinal and behavior changes...
  100. ncbi Donation after cardiac death in the US: history and use
    Peter L Abt
    Division of Solid Organ Transplantation, Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA
    J Am Coll Surg 203:208-25. 2006
  101. pmc Trends in the place of death of cancer patients, 1992-1997
    Frederick Burge
    Department of Family Medicine, Dalhousie University, Halifax, NS
    CMAJ 168:265-70. 2003
    ..We carried out a study to describe the yearly trends in the place of death between 1992 and 1997 and to determine predictors of out-of-hospital death for adults with cancer in Nova Scotia.

Research Grants73

  1. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  2. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  3. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  4. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..and underpin the programs to be implemented under this new project Infections are the second most common cause of death in thalassemia major...
  5. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..The injury culminates in the death of cardiomyocytes that were viable immediately before myocardial reperfusion and occurs despite timely reperfusion ..
  6. Optimization of DNA Repair by Abh8
    Lauren Endres; Fiscal Year: 2013
    ..If left unrepaired, these DNA lesions can result in cell death or mutations...
  7. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
    ..reductase 1 (TxRd1), is an essential selenoprotein with defined roles in redox regulation of cell growth, death (apoptosis), transcription, DNA repair, and angiogenesis...
  8. Vaccine Development for Falciparum Malaria in Pregnant Women and Their Offspring
    Ian C Michelow; Fiscal Year: 2013
    ..malaria, but that are not recognized by IgG antibodies from mothers whose infants suffered severe disease or death due to malaria. Dr...
  9. Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
    James D Bryers; Fiscal Year: 2012
    ..Nosocomial infections are the fourth leading cause of death in the U.S. with >2 million cases annually (or ~10% of American hospital patients)...
  10. Iron-mediated vascular disease in sickle cell disease.
    John C Wood; Fiscal Year: 2010
    ..endocrine glands and other tissues results in severe oxidant damage, organ failure, malignant transformation and death, if unrecognized and untreated...
  11. Ligand Directed Transdermal siRNA Delivery to Improve Wound Healing
    David M Evans; Fiscal Year: 2012
    ..large portions of the skin as a result of wounds and wound-related infection may lead to major disability or even death. Every year in the United States more than 1.25 million people suffer burns and 6...
  12. Multi-targeted Countermeasures against Acute and Delayed Effects of OP Exposure
    John A Butera; Fiscal Year: 2013
    ..seizures, paralysis, mucous secretions, eye irritation, cardiorespiratory depression, GI distress, and eventually, death. Additionally, OP exposure initiates a sequelae of mechanisms leading to delayed neurodegeneration in the CNS;..
  13. Prevention of Acute Lung Injury by IL-6 activated STAT3
    Ana Moran; Fiscal Year: 2010
    Trauma is accompanied frequently by hemorrhagic shock and is the leading cause of death for those under 45 years old in the United States...
  14. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    Mona Fouad; Fiscal Year: 2013
    ..Both screened and control participants are to be followed for at least 13 years from randomization for cancer and death ascertainment to determine if the screening regimen results in reduced disease-specific mortality...
  15. Novel Mitochondrial Mechanisms of Ethanol-Induced Cardiac Injury in Aged Females
    DONNA HOPE KORZICK; Fiscal Year: 2010
    ..Of particular interest are adaptive changes in proteins associated with metabolism, oxidative stress, and cell death. Specific aims are as follows: 1) chronic ethanol ingestion will exacerbate age-related increases in I/R injury in ..
  16. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    BARBARA O'BRIEN; Fiscal Year: 2013
    ..Both screened and control participants are to be followed for at least 13 years from randomization for cancer and death ascertainment to determine if the screening regimen results in reduced disease-specific mortality...
  17. Vitamin D3, Interference with Androgen Signal and Inhibition of Prostate Cancer
    Bandana Chatterjee; Fiscal Year: 2013
    ..cancer is a major health concern among elderly men, and metastatic prostate cancer is a leading cause of cancer death in men in the USA, second only to death from lung cancer. Risk for the disease rises from the 5th decade of life...
  18. Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of Sclerod
    Robert B Zurier; Fiscal Year: 2012
    ..to organ dysfunction including debilitating esophageal dysfunction and pulmonary fibrosis, the leading cause of death for SSc patients...
  19. ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYS
    Patrice G Guyenet; Fiscal Year: 2013
    ..such as obstructive sleep apnea (OSA), the treatment of pain with opiates, central sleep apnea, sudden infant death syndrome (SIDS), and rare diseases such as congenital central hypoventilation syndrome (CCHS)...
  20. Soluble Epoxide Hydrolase as a Target for Ischemic Cardioprotection
    Donna M Van Winkle; Fiscal Year: 2012
    ..triphenyltetrazolium staining, cardiac function with a left ventricular conductance catheter, and in vitro cell death by propidium iodide uptake. Measurement of EETs will be performed by liquid chromatography/mass spectrometry...
  21. Reactive (AA)Amyloidosis
    Merrill D Benson; Fiscal Year: 2013
    ..by the extracellular deposition of protein fibrils which disrupts normal organ function and usually leads to death from renal, hepatic or cardiac failure...
  22. Natural History and Prevention of Viral Hepatitis Among Alaska Natives
    BRIAN JAMES MCMAHON; Fiscal Year: 2013
    ..B virus (HBV) can cause chronic infection, resulting in cirrhosis of the liver, liver cancer, liver failure, and death.[4] [5] Much like the hepatitis A vaccine, hepatitis B immunization strategies for infants, children, adolescents ..
  23. Pituitary dysfunction, behavioral symptoms, and quality of life after blast mTBI
    CHARLES WILLIAM WILKINSON; Fiscal Year: 2012
    ..Although termed "mild" in comparison to brain injuries resulting in death, coma, or paralysis, mTBI, particularly repetitive mTBI characteristic of soldiers deployed to Operation Iraqi ..
  24. Pathogenesis and Treatment of Liver Disease in Transaldolase Deficiency
    Andras Perl; Fiscal Year: 2013
    ..HCC was the leading cause of death in both TAL+/- (39/229;17%) and TAL-/- mice (45/97;46%) as compared to TAL+/+ littermates (1/102;1%)...
  25. Agrin/alpha 3 Na,K-ATPase signaling at the neuromuscular junction
    Martin A Smith; Fiscal Year: 2012
    ..lateral sclerosis, toxins such as botulinum toxin, or traumatic injury, results in muscle weakness and even death. Thus, understanding the mechanisms responsible for the formation and maintenance of the neuromuscular junction ..
  26. Impact of the P479L Variant in CPT1A on Infant Mortality in Alaska
    David M Koeller; Fiscal Year: 2011
    ..Like other disorders of fatty acid oxidation, CPT1A deficiency can lead to sudden infant death. Preliminary evidence indicates that 26% of all Alaska Native infants are homozygous for the c...
  27. Epigenetic mechanisms relevant to the pathogenesis of ALS
    Neil W Kowall; Fiscal Year: 2013
    ..Despite this, the cause of motor neuron death is unknown and the role of mutant SOD1 in the generation of oxidative stress in ALS has not been established...
  28. Regulation of ER stress-induced cell death
    Randal J Kaufman; Fiscal Year: 2013
    ..Aim 3, How do eIF2a phosphorylation and CHOP expression prevent cell death? We will evaluate the role of ATF4 in cell death and screen for genes that regulate ER stress induced cell death...
  29. Inhibition of human neutrophil function by Francisella tularensis
    Lee Ann H Allen; Fiscal Year: 2012
    ..Indeed, inhalation of as few as ten organisms is sufficient to cause severe pneumonic disease, tissue necrosis and death. Because of its extreme virulence via the aerosol route, Ft is a potential bioweapon and has been classified as a ..
  30. Sphingolipid Metabolism in Drosophila Development
    Julie D Saba; Fiscal Year: 2013
    ..underlies many human disease states including neurodegenerative diseases, cardiomyopathies, cancer, programmed cell death, and bacterial and viral infections. Thus, our research plan has potentially broad translational significance.
  31. Enterococcus faecalis, Colorectal Cancer, and Bystander Effects
    Mark M Huycke; Fiscal Year: 2012
    ..Sporadic colorectal cancer is a leading cause of cancer and cancer death worldwide. These tumors are believed to arise, in part, because of bacteria in the colon...
  32. Translational Machinery in Stress Signaling and Tumor Suppression
    THOMAS J contact BEGLEY; Fiscal Year: 2010
    ..such as endoplasmic reticulum (ER) stress, can arrest cell growth and promote the repair of damage or promote cell death. Similarly, translational regulation has recently been associated with the DNA damage response, and appears to ..
  33. Targeting Inflammation for the Amelioration of Cisplatin-Hearing Loss
    Vickram Ramkumar; Fiscal Year: 2011
    ..Other treatment approaches target proteins involved in apoptosis which contribute to death of outer hair cells (OHCs)...
  34. Investigating Mechanism of Intracellular Rotational Transport with Optical T
    Jeffrey N Anker; Fiscal Year: 2012
    ..and the depletion of antioxidants, cause global cytoskeletal damage and dysfunction, DNA damage, and cell death. We will test this hypothesis by studying the effect of nanoparticle composition on the motion and transport of ..
  35. Genetic and physiological causes of inherited Vascular and Metabolic Diseases
    Arya Mani; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Coronary artery disease (CAD) and its consequences are the single largest cause of death in the United States. CAD risk factors include high blood pressure, high cholesterol and diabetes...
  36. Collagen X and heparan sulfate proteoglycan in the hematopoietic stem cell niche.
    ELIZABETH G SWEENEY; Fiscal Year: 2012
    ..modification, transcriptional regulation of differentiation, growth hormones, respiration, cell cycle, cell death, spermatogenesis, obesity, stress, immunology, eye development, and dinosaur paleobiology...
  37. MOLECULAR BASIS OF REOVIRUS PATHOGENESIS
    Terence S Dermody; Fiscal Year: 2013
    ..Targets of reovirus infection in vivo will be monitored for apoptotic cell death following inoculation with wild-type and als-mutant viruses to define the function of a1s- induced apoptosis in ..
  38. Insulin Signaling and the Heart in Diabetes
    EVAN DALE ABEL; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Heart disease remains the leading cause of death in individuals with diabetes...
  39. Retinoid Metabolism and Alcohol Induced Disease
    William S Blaner; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Estimates of death rates caused by chronic alcohol consumption, published in 2004 by the World Health Organization, indicate that alcohol accounts for approximately 1.8 million deaths per year...
  40. Prostate cancer chemoprevention by penta-galloyl-glucose
    Junxuan Lu; Fiscal Year: 2013
    ..beta-D-glucose (PGG) for the chemoprevention of prostate cancer (PCa), the number 2 cause of cancer death in US men...
  41. Role of JAK2-PAK1 interaction in prolactin-dependent signaling
    Maria Diakonova; Fiscal Year: 2013
    ..in breast cancer, the leading type of cancer in women and the second leading cause (after lung cancer) of cancer death among women. In 2008, 40,480 women are expected to die from breast cancer in the U.S...
  42. Molecular Markers for Progression of Pulmonary Fibrosis in Systemic Sclerosis
    Shervin Assassi; Fiscal Year: 2013
    ..Pulmonary involvement is the primary cause of SSc-related death. Sequential measurements of pulmonary function in patients with SSc have shown remarkable variability in the ..
  43. Role and Regulation of INrf2
    ANIL KUMAR JAISWAL; Fiscal Year: 2013
    ..interaction with PGAM5/BclXL/Bcl2, HSP90, and pICln and its significance in cellular protection and cell survival/death. The domain deletion, transfection, immunoprecipitation, Western analysis, reporter and apoptosis assays will be ..
  44. Community Participation Research of Breastfeeding Disparities in African American
    Tamar Ringel Kulka; Fiscal Year: 2009
    ..episodes, type I and type II diabetes, episodes of infant diarrhea, and incidents of childhood leukemia and sudden death syndrome...
  45. Novel PET imaging agents for early diagnosis of plaque deposition in Alzheimer's
    Padmakar Kulkarni; Fiscal Year: 2010
    ..Such developments would be a huge breakthrough for a disease that has no cure and can only be diagnosed after death when a patients'brain is autopsied...
  46. Combination drug treatment to inhibit multiple cell death pathways after TBI
    ALAN IRA FADEN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): This application entitled "Attenuation of Diverse Cell Death Pathways after Traumatic Brain Injury by Multi- drug Combination Therapy" addresses Broad Challenge Area (15): Translational Science and ..
  47. Inhibition of IkK to treat lethal Graft-vs.-Host Disease
    Patrick Flood; Fiscal Year: 2009
    ..bone marrow or stem cell transplant from a perfectly matched donor and can cause multiple complications including death of the recipient...
  48. MODULATION OF IFN ACTION VIA NOVEL REGULATORY FACTORS
    DHAN V KALVAKOLANU; Fiscal Year: 2013
    ..One of them is the death associated protein kinase1 (DAPK1), an important regulator of apoptosis, cell cycle, and metastasis...
  49. TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion Injury
    LORI ANN HOLLE; Fiscal Year: 2011
    ..due to embolic stroke, inflammation and edema due to IRI is responsible for a large amount of neuronal cell death in the penumbrum, a large zone around the infarcted area...
  50. Enzymatic Regulation of S-Glutathionylation : Role in Apoptosis and Disease
    John J Mieyal; Fiscal Year: 2012
    ..factor in PD, is likely to perturb natural redox signaling and promote inflammatory responses and apoptotic cell death. Recent studies in the laboratory of the Principal Investigator have revealed that treatment of human dopaminergic ..
  51. Regulation of myocardial growth and death by GSK-3
    Junichi Sadoshima; Fiscal Year: 2013
    ..Glycogen synthase kinase-3 (GSK-3), a serine/threonine kinase, plays an important role in regulating growth and death of cardiomyocytes...
  52. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..manifestation of repolarization in ventricular myocytes, is a major cause of cardiac arrhythmia and sudden death. Long QT syndrome (LQTS) can have a genetic basis or be induced by drug exposure or physiological stress...
  53. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..manifestation of repolarization in ventricular myocytes, is a major cause of cardiac arrhythmia and sudden death. Long QT syndrome (LQTS) can have a genetic basis or be induced by drug exposure or physiological stress...
  54. Improving TB Diagnosis in Children with and without HIV in Kenya
    Rinn Song; Fiscal Year: 2013
    ..Despite the substantial global burden of pediatric TB and the higher risk of severe disease and death among young children than adults, childhood TB has been relatively neglected...
  55. Protein Nitration in the Placenta
    Leslie Myatt; Fiscal Year: 2012
    ..7% of pregnancies and being the leading cause of fetal growth restriction, indicated preterm delivery and maternal death particularly with early onset severe disease...
  56. A MicroRNA Approach to Screen for Sporadic Colon Cancer Exfoliately in Human Stoo
    Farid E Ahmed; Fiscal Year: 2010
    ..CRC is the third leading cause of cancer death among white, African American, Asian/Pacific Islander and Indian/Alaska Native men, but second among Hispanic men ..
  57. Antiarrhythmic Mechanisms in the Hearts of Hibernating Mammals
    Lai Hua Xie; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Sudden cardiac death (SCD) caused by severe arrhythmias such as ventricular tachycardia (VT) and ventricular fibrillation (VF), claims the lives of 300,000-400,000 Americans annually...
  58. Phage Display for Improved Peptide-based Tumor Targeting and Imaging Agents
    Susan L Deutscher; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cancer is the second leading cause of death in the United States and US Veterans. Over 28% of cancer diagnoses in US Veterans in 2009 were for prostate, breast, and ovarian carcinoma...
  59. Arcuate nucleus glutamatergic neurons modulate energy homeostasis
    Anthony N van den Pol; Fiscal Year: 2013
    ..and the resultant increase in heart disease, hypertension, diabetes, joint dysfunction, stroke, cancer, and early death that is estimated to cost upwards of 75 billion dollars per year...
  60. Mechanisms of Sex Determination in Zebrafish
    JOHN HARVEY POSTLETHWAIT; Fiscal Year: 2013
    ..Preliminary experiments show excess cell death in homozygous mutant juvenile gonads and suggest the hypothesis that 1) environmental and genetic factors affect ..
  61. Regulation of AKAP79 Postsynaptic Membrane Targeting
    MARK L DELL'ACQUA; Fiscal Year: 2012
    ..also have relevance for understanding how excessive glutamate receptor activation leads to excitotoxic neuronal death in neurodegenerative diseases, brain injury and stroke...
  62. The Neuroimmunology of Viral Infection
    DANIEL J CARR; Fiscal Year: 2013
    ..in the industrialized world, and frank sporadic encephalitis, a rare but debilitating disease that can result in death. Resistance to infection includes the innate immune system...
  63. Extracorporeal Support for Emergent (Uncontrolled) Donation Following Cardiac Dea
    Shawn J Pelletier; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Extracorporeal Support for Emergent (Uncontrolled) Donation Following Cardiac Death Introduction: The limited availability of donor organs for transplantation has led to an increased interest in the ..
  64. Significance of Caspase-Mediated Cleavage of PARP-1 in Cell Death
    KAREN DAVID; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Significance of Caspase-Mediated Cleavage of PARP-1 in Cell Death Poly (ADP-ribose) polymerase-1 (PARP-1) maintains cell function by facilitating DNA repair...
  65. Systematic analysis of cell death regulation in mosquitoes
    Lei Zhou; Fiscal Year: 2009
    Title: Systematic analysis of cell death regulation in mosquitoes. Cell death (apoptosis) is an important component of the vector/host immuno-response mechanism...
  66. Innate Immune Mechanisms of Motor Neuron Injury
    Timothy Vartanian; Fiscal Year: 2010
    ..Relatedness: A central question in neurodegenerative diseases is how specific populations of neurons undergo cell death. Selective degeneration of motor neurons occurs in the setting of diverse insults including RNA viruses such as ..
  67. Vascular smooth muscle apoptosis prevention by glucose
    Frank Brosius; Fiscal Year: 2005
    ..It is therefore not surprising that modulation of these processes affects cell death pathways...
  68. ICE FAMILY AND NEURONAL CELL DEATH
    Junying Yuan; Fiscal Year: 1999
    ..In the nematode C. elegans the gene ced -3 is essential for cells to undergo programmed cell death. Interleukin-1b converting enzyme (ICE) has been identified as a vertebrate homologue of Ced-3...
  69. Connexins in Ischemia-Induced Neuronal Death
    Michael Bennett; Fiscal Year: 2007
    ..The molecular mechanisms underlying this pattern of neuronal death are not well understood...
  70. PSYCHOSOCIAL FACTORS IN SUDDEN CARDIAC DEATH
    Sue Thomas; Fiscal Year: 2002
    This proposal "Psychosocial Factor Outcome Study in Sudden Cardiac Death (PFOS)" constitutes an independent project complimentary to the ongoing NIH clinical trial, "Sudden Cardiac Death Heart Failure Trial (SCD-HeFT)...
  71. Red Blood Cell Omega-3 Fatty Acids and Coronary Artery Disease
    Luc Djousse; Fiscal Year: 2010
    ..Some observational studies and randomized trials have suggested that n-3 FA may lower the risk of sudden cardiac death (SCD) and coronary events, possibly through antiarrhythmic effects...
  72. Genes That Regulate Neuronal Cell Death
    Robert Freeman; Fiscal Year: 2009
    Cell death is widespread during the development of the nervous system where it helps to ensure that the proper number and types of connections are formed between neurons and their targets...
  73. A Novel Cell Death Pathway Induced by Galectin-1
    Linda Baum; Fiscal Year: 2004
    Cell death is a critical regulatory process in development, in homeostasis, and in disease. Many cell death triggers have been identified, although little is known about many of the molecular pathways that lead to cell death...