genetic translocation

Summary

Summary: A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.

Top Publications

  1. ncbi Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
    S E Artandi
    Department of Adult Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 406:641-5. 2000
  2. ncbi The impact of translocations and gene fusions on cancer causation
    Felix Mitelman
    Lund University, Department of Clinical Genetics, Lund University Hospital, SE 221 85 Lund, Sweden
    Nat Rev Cancer 7:233-45. 2007
  3. pmc Intermingling of chromosome territories in interphase suggests role in translocations and transcription-dependent associations
    Miguel R Branco
    MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom
    PLoS Biol 4:e138. 2006
  4. pmc The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations
    D O Ferguson
    Howard Hughes Medical Institute, The Children s Hospital, The Center for Blood Research, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:6630-3. 2000
  5. ncbi The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers
    M Ohta
    Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Cell 84:587-97. 1996
  6. pmc The neurobeachin gene is disrupted by a translocation in a patient with idiopathic autism
    D Castermans
    J Med Genet 40:352-6. 2003
  7. ncbi Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
    Scott A Tomlins
    Department of Pathology, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109 0602, USA
    Science 310:644-8. 2005
  8. pmc No requirement for V(D)J recombination in p53-deficient thymic lymphoma
    M J Liao
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill Medical School, Chapel Hill, North Carolina 27599, USA
    Mol Cell Biol 18:3495-501. 1998
  9. ncbi Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains
    Jacob A Aten
    Center for Microscopical Research, Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, Netherlands
    Science 303:92-5. 2004
  10. pmc AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations
    Davide F Robbiani
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
    Cell 135:1028-38. 2008

Detail Information

Publications263 found, 100 shown here

  1. ncbi Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
    S E Artandi
    Department of Adult Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 406:641-5. 2000
    ..Our data suggest a model in which telomere dysfunction brought about by continual epithelial renewal during life generates the massive ploidy changes associated with the development of epithelial cancers...
  2. ncbi The impact of translocations and gene fusions on cancer causation
    Felix Mitelman
    Lund University, Department of Clinical Genetics, Lund University Hospital, SE 221 85 Lund, Sweden
    Nat Rev Cancer 7:233-45. 2007
    ..With the advent of new and powerful investigative tools that enable the detection of cytogenetically cryptic rearrangements, this proportion is likely to increase substantially...
  3. pmc Intermingling of chromosome territories in interphase suggests role in translocations and transcription-dependent associations
    Miguel R Branco
    MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom
    PLoS Biol 4:e138. 2006
    ..These findings suggest that local chromatin conformation and gene transcription influence the extent with which chromosomes interact and affect their overall properties, with direct consequences for cell-type specific genome stability...
  4. pmc The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations
    D O Ferguson
    Howard Hughes Medical Institute, The Children s Hospital, The Center for Blood Research, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:6630-3. 2000
    ..We conclude that nonhomologous DNA end-joining plays a crucial role as a caretaker of the mammalian genome, and that an alternative repair pathway exists that often leads to nonreciprocal translocations...
  5. ncbi The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers
    M Ohta
    Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Cell 84:587-97. 1996
    ..Aberrant transcripts of the FHIT locus were found in approximately 50% of esophageal, stomach, and colon carcinomas...
  6. pmc The neurobeachin gene is disrupted by a translocation in a patient with idiopathic autism
    D Castermans
    J Med Genet 40:352-6. 2003
  7. ncbi Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
    Scott A Tomlins
    Department of Pathology, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109 0602, USA
    Science 310:644-8. 2005
    ..These results have implications in the development of carcinomas and the molecular diagnosis and treatment of prostate cancer...
  8. pmc No requirement for V(D)J recombination in p53-deficient thymic lymphoma
    M J Liao
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill Medical School, Chapel Hill, North Carolina 27599, USA
    Mol Cell Biol 18:3495-501. 1998
    ....
  9. ncbi Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains
    Jacob A Aten
    Center for Microscopical Research, Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, Netherlands
    Science 303:92-5. 2004
    ..Our results support the breakage-first theory to explain the origin of chromosomal translocations...
  10. pmc AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations
    Davide F Robbiani
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
    Cell 135:1028-38. 2008
    ..Thus, in addition to producing somatic mutations and DNA breaks in antibody genes, AID is also responsible for the DNA lesions in oncogenes that are required for their translocation...
  11. ncbi The loss of a single telomere can result in instability of multiple chromosomes in a human tumor cell line
    Laure Sabatier
    Laboratoire de Radiologie et Oncologie, Commissariat a l Energie Atomique, Fontenay aux Roses, France
    Mol Cancer Res 3:139-50. 2005
    ..Factors promoting telomere loss are therefore likely to have an important role in generating the karyotype evolution associated with human cancer...
  12. pmc Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease
    T Goossens
    Institute for Genetics, University of Cologne, 50931 Cologne, Germany
    Proc Natl Acad Sci U S A 95:2463-8. 1998
    ....
  13. ncbi Molecular diagnosis of Burkitt's lymphoma
    Sandeep S Dave
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    N Engl J Med 354:2431-42. 2006
    ..We examined whether gene-expression profiling could reliably distinguish Burkitt's lymphoma from diffuse large-B-cell lymphoma...
  14. ncbi The protooncogene TCL1 is an Akt kinase coactivator
    J Laine
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell 6:395-407. 2000
    ..In vivo, TCL1 forms trimers, which associate with Akt. TCL1 facilitates the oligomerization and activation of Akt. Our data show that TCL1 is a novel Akt kinase coactivator, which promotes Akt-induced cell survival and proliferation...
  15. ncbi Effect of antiviral treatment in patients with chronic HCV infection and t(14;18) translocation
    Francesca Giannelli
    Department of Internal Medicine, University of Florence, School of Medicine, Italy
    Blood 102:1196-201. 2003
    ..This in turn suggests that antiviral treatment may help prevent or treat HCV-related LPDs...
  16. ncbi MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia
    Scott A Armstrong
    Departments of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Nat Genet 30:41-7. 2002
    ..Establishing that MLL is a unique entity is critical, as it mandates the examination of selectively expressed genes for urgently needed molecular targets...
  17. pmc Cruciform DNA structure underlies the etiology for palindrome-mediated human chromosomal translocations
    Hiroki Kurahashi
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    J Biol Chem 279:35377-83. 2004
    ..Our data imply that for human chromosomes, translocation susceptibility is mediated by PATRRs and likely results from their unstable conformation...
  18. pmc Signatures of selection in fusion transcripts resulting from chromosomal translocations in human cancer
    Iñigo Ortiz de Mendíbil
    Department of Genetics, University of Navarra, Pamplona, Spain
    PLoS ONE 4:e4805. 2009
    ..However, it has also been suggested that functional constraints might contribute to delimit the position of translocation breakpoints within the genes involved, but a quantitative analysis of such contribution has been lacking...
  19. pmc The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif
    C G Begley
    Navy Medical Oncology Branch, National Naval Medical Center, Bethesda, MD 20814
    Proc Natl Acad Sci U S A 86:10128-32. 1989
    ..SCL mRNA is observed in "early" hematopoietic tissues. Taken together, these studies lead to the speculation that SCL plays a role in differentiation and/or commitment events during hematopoiesis...
  20. ncbi Chromosome translocations: dangerous liaisons revisited
    J D Rowley
    Department of Medicine, University of Chicago Medical Center, Illinois 60637, USA
    Nat Rev Cancer 1:245-50. 2001
    ..The prevailing view for most of this period was that chromosome changes were secondary events. What happened to change this view?..
  21. ncbi The asynaptic chromatin in spermatocytes of translocation carriers contains the histone variant gamma-H2AX and associates with the XY body
    R Sciurano
    Biologia Celular, CIR, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    Hum Reprod 22:142-50. 2007
    ..Because in many of these carriers spermatogenesis is deeply disturbed at the spermatocyte level, the association of autosomal chromatin with the XY body may impair the spermatocyte life...
  22. pmc Nucleotide-resolution mapping of topoisomerase-mediated and apoptotic DNA strand scissions at or near an MLL translocation hotspot
    Marc Edouard Mirault
    Unit of Health and Environment, Centre de Recherche du Centre Hospitalier Universitaire de Quebec Centre Hospitalier de l Universite Laval, Quebec City, Quebec, Canada
    Am J Hum Genet 79:779-91. 2006
    ..ELMPCR provides a new tool for investigating the role of DNA topoisomerases in fundamental genetic processes and translocations associated with cancer treatments involving topoisomerase-targeted drugs...
  23. ncbi Recurrent chromosome aberrations in cancer
    F Mitelman
    Department of Clinical Genetics, University Hospital, SE 221 85, Lund, Sweden
    Mutat Res 462:247-53. 2000
    ..Data obtained during recent years strongly suggest that corresponding breakthroughs will be achieved in solid tumors within a not-too-distant future...
  24. ncbi Mouse c-myc oncogene is located on chromosome 15 and translocated to chromosome 12 in plasmacytomas
    S Crews
    Science 218:1319-21. 1982
    ..The translocated c-myc sequence is not the same oncogene detected in urine plasmacytomas by the NIH-3T3 cell transformation assay...
  25. ncbi Origins of chromosome translocations in childhood leukaemia
    Mel F Greaves
    LRF Centre for Cell and Molecular Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK
    Nat Rev Cancer 3:639-49. 2003
    ..How, when and where do translocations arise? And can these insights aid our understanding of the natural history, pathogenesis and causes of leukaemia?..
  26. pmc Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157
    Qi Jin
    State Key Laboratory for Molecular Virology and Genetic Engineering, Beijing 100052, China
    Nucleic Acids Res 30:4432-41. 2002
    ..coli strains. All of these could be subjected to investigations towards novel preventative and treatment strategies against shigellosis...
  27. pmc Chromosomal rearrangement interferes with meiotic X chromosome inactivation
    David Homolka
    Institute of Molecular Genetics, Academy of Sciences of Czech Republic, 142 20 Prague 4, Czech Republic
    Genome Res 17:1431-7. 2007
    ..Our findings provide direct evidence on the MSUC acting at the mRNA level, and implicate that autosomal asynapsis in meiosis may cause male sterility by interfering with meiotic sex chromosome inactivation...
  28. ncbi A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations
    K Aoki
    Department of Immunology, National Institute of Health, Tokyo, Japan
    Nat Genet 10:167-74. 1995
    ....
  29. pmc MLL fusions: pathways to leukemia
    Han Liu
    Molecular Oncology, Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Biol Ther 8:1204-11. 2009
    ..Here, we summarize the critical biological and pathological activities of MLL and MLL fusions, and discuss available models and potential therapeutic targets of MLL associated leukemias...
  30. ncbi siRNA-mediated AML1/MTG8 depletion affects differentiation and proliferation-associated gene expression in t(8;21)-positive cell lines and primary AML blasts
    J Dunne
    Cancer Research UK Medical Oncology Laboratory, Barts and the London School of Medicine, London, UK
    Oncogene 25:6067-78. 2006
    ..Furthermore, the results suggest that the specific targeting of AML1/MTG8 function may be a promising approach for complementing existing treatment strategies...
  31. ncbi In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia
    Joseph L Wiemels
    Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California San Francisco 94143 0560, USA
    Blood 99:3801-5. 2002
    ....
  32. ncbi An Atlas on genes and chromosomes in oncology and haematology
    J L Huret
    Genetics, Dept of Medical Information, UMR 8125 CNRS IGR, University Hospital, F 86021 Poitiers, France
    Cell Mol Biol (Noisy-le-grand) 50:805-7. 2004
    ..It contributes to 'meta-medicine', a mediation using new information technology, between the overflowing information provided by the scientific community and the individual practitioner...
  33. ncbi Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia
    T Nakamura
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research and Development Center, Maryland 21702, USA
    Nat Genet 12:154-8. 1996
    ....
  34. ncbi Proteins encoded by genes involved in chromosomal alterations in lymphoma and leukemia: clinical value of their detection by immunocytochemistry
    Brunangelo Falini
    Institute of Hematology, University of Perugia, Italy
    Blood 99:409-26. 2002
    ....
  35. ncbi Common fragile sites as targets for chromosome rearrangements
    Martin F Arlt
    Department of Human, Genetics University of Michigan, 4909 Buhl Box 0618, 1241 E Catherine Street, Ann Arbor, MI 48109, USA
    DNA Repair (Amst) 5:1126-35. 2006
    ..Here we review the relationship of fragile sites to chromosome rearrangements, particularly in tumor cells, and discuss the mechanisms that may be involved...
  36. ncbi A chromosomal translocation in cyclin D1-negative/cyclin D2-positive mantle cell lymphoma fuses the CCND2 gene to the IGK locus
    Stefan Gesk
    Blood 108:1109-10. 2006
  37. ncbi Lymphoid malignancies: the dark side of B-cell differentiation
    A L Shaffer
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 2:920-32. 2002
    ..The similarities and differences between malignant and normal B cells indicate strategies for the treatment of these cancers...
  38. pmc Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis
    Sandrine Roulland
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, 13288 Marseille, France
    J Exp Med 203:2425-31. 2006
    ..These findings strongly impact both on the current understanding of disease progression and on the proper handling of t(14;18) frequency in blood as a potential early biomarker for lymphoma...
  39. pmc Positional stability of single double-strand breaks in mammalian cells
    Evi Soutoglou
    National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Nat Cell Biol 9:675-82. 2007
    ..These results support a contact-first model in which chromosome translocations predominantly form among spatially proximal DSBs...
  40. ncbi Template switching during break-induced replication
    Catherine E Smith
    Department of Microbiology, Columbia University Medical Center, 701 West 168th Street, New York, New York 10032, USA
    Nature 447:102-5. 2007
    ..This dynamic process could function to promote gene conversion by capture of the displaced invading strand at two-ended DSBs to prevent BIR...
  41. ncbi Role of AML1/Runx1 in the pathogenesis of hematological malignancies
    Mineo Kurokawa
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo113 8655, Japan
    Cancer Sci 94:841-6. 2003
    ..However, AML1-related translocations or haploinsufficiency of AML1 are not immediately leukemogenic in animal models, suggesting that additional genetic events are required for the development of full-blown leukemia...
  42. ncbi The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25
    M Ladanyi
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Oncogene 20:48-57. 2001
    ..Oncogene (2001) 20, 48 - 57...
  43. ncbi Incidence of additional genetic changes in the TEL and AML1 genes in DCOG and COALL-treated t(12;21)-positive pediatric ALL, and their relation with drug sensitivity and clinical outcome
    W A G Stams
    Erasmus MC, Sophia Children s Hospital, Erasmus University Medical Center Rotterdam, Division of Pediatric Oncology Hematology, Rotterdam, The Netherlands
    Leukemia 20:410-6. 2006
    ..78, 95% CI 1.45-23.0; P=0.01) is an independent prognostic factor in DCOG- and COALL-treated t(12;21)-positive ALL...
  44. ncbi A mutational analysis of Caenorhabditis elegans in space
    Yang Zhao
    Department of Medical Genetics, University of British Columbia, Life Sciences Centre, Room 1364 2350 Health Sciences Mall, Vancouver, BC, Canada
    Mutat Res 601:19-29. 2006
    ....
  45. pmc AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations
    Davide F Robbiani
    The Rockefeller University, New York, NY 10065, USA
    Mol Cell 36:631-41. 2009
    ..We conclude that AID produces DSBs throughout the genome, which can lead to lymphoma-associated chromosome translocations in mature B cells...
  46. ncbi Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas
    L W Stanton
    Nature 303:401-6. 1983
    ..The second and third exons of the mouse c-myc gene are substantially conserved in the v-myc gene of the avian retrovirus, MC29...
  47. ncbi Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22
    J Groffen
    Cell 36:93-9. 1984
    ..The highly specific presence of a chromosomal breakpoint within bcr in Ph'-positive CML patients strongly suggests the involvement of bcr in this type of leukemia...
  48. ncbi Mechanisms of B-cell lymphoma pathogenesis
    Ralf Kuppers
    Institute for Cell Biology Tumor Research, University of Duisburg Essen, Medical School, Germany
    Nat Rev Cancer 5:251-62. 2005
    ..Recent insights into the lymphomagenic role of factors supplied by the microenvironment also offer new therapeutic strategies...
  49. ncbi The topological organization of chromosomes 9 and 22 in cell nuclei has a determinative role in the induction of t(9,22) translocations and in the pathogenesis of t(9,22) leukemias
    S Kozubek
    Institute of Biophysics, Academy of Sciences, Brno, Czech Republic
    Chromosoma 108:426-35. 1999
    ..HL60 cells and bone marrow cells. This finding suggests that the specific chromatin structure mentioned might be responsible for the high rate of induction of t(9;22)-positive leukemias in the human population...
  50. ncbi Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney
    Michael S Anglesio
    Department of Pathology, British Columbia Research Institute for Children s and Women s Health, University of British Columbia, Vancouver, BC, V5Z 4H4, Canada
    Hum Mol Genet 13:2061-74. 2004
    ..Our findings implicate Hace1 as a novel ubiquitin-protein ligase and demonstrate that its expression is very low in primary Wilms' tumors...
  51. pmc Spatial genome organization in the formation of chromosomal translocations
    Karen J Meaburn
    National Cancer Institute, NIH, Bethesda, MD 20892, United States
    Semin Cancer Biol 17:80-90. 2007
    ..We review here the emerging principles of spatial genome organization and discuss the implications of non-random spatial genome organization for the genesis and specificity of cancerous chromosomal translocations...
  52. ncbi The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome
    Fred S Dietrich
    Biozentrum der Universitat Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Science 304:304-7. 2004
    ..cerevisiae included a whole genome duplication or fusion of two related species and showed, through inferred ancient gene orders, which of the duplicated genes lost one copy and which retained both copies...
  53. ncbi A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma
    Masumichi Saito
    Institute for Cancer Genetics, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
    Cancer Cell 12:280-92. 2007
    ..A subset of DLBCL displays chromosomal translocations or mutations that disrupt the IRF4-responsive region in the BCL6 promoter and block its downregulation by CD40 signaling...
  54. pmc Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell-like diffuse large B cell lymphoma
    Georg Lenz
    Metabolism Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 204:633-43. 2007
    ..Accordingly, aberrant switch recombination was responsible for translocations in ABC DLBCLs involving BCL6, MYC, and a novel translocation partner, SPIB...
  55. ncbi Novel genomic imbalances and chromosome translocations involving c-myc gene in Burkitt's lymphoma
    D B Zimonjic
    Laboratory of Experimental Carcinogenesis, Division of Basic Sciences, National Cancer Institute, NIH, Bethesda, MD 20892-4255, USA
    Leukemia 15:1582-8. 2001
    ..Duplication of the bands 1q23-24 commonly observed in EBV-negative lines was identified only in highly tumorigenic CA46 cells suggesting that this region harbor gene(s) associated with tumor cell invasiveness...
  56. pmc Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma
    L R Finger
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140
    Proc Natl Acad Sci U S A 86:5039-43. 1989
    ..Rearrangement of the TCL5 locus in a human melanoma cell line carrying a del(1p32) further implies that the TCL5 gene may play a role in malignant transformation...
  57. pmc Synovial sarcoma: from genetics to genetic-based animal modeling
    Malay Haldar
    Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112 5331, USA
    Clin Orthop Relat Res 466:2156-67. 2008
    ....
  58. pmc Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript
    I Fligman
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Am J Pathol 147:1592-9. 1995
    ..Thus, a diagnosis of SS may be confirmed in > 90% of cases using RT-PCR detection of the chimeric transcript resulting from the t(X;18), and the incidence of molecular variants appears low...
  59. ncbi MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations
    M H Stern
    Laboratoire d Hématologie Moléculaire, Hopital Saint Louis, Paris, France
    Oncogene 8:2475-83. 1993
    ..This gene, named MTCP-1 (Mature T Cell Proliferation-1) is the first candidate gene potentially involved in the leukemogenic process of mature T cell proliferations...
  60. ncbi Spatial proximity of translocation-prone gene loci in human lymphomas
    Jeffrey J Roix
    National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 34:287-91. 2003
    ..Our results suggest that the formation of specific translocations in human lymphomas, and perhaps other tissues, is determined in part by higher-order spatial organization of the genome...
  61. pmc Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein
    Paul M Ayton
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Cell Biol 24:10470-8. 2004
    ..Our results define a critical role for the CXXC DNA binding domain in MLL-associated oncogenesis, most likely via epigenetic recognition of CpG DNA sites within the regulatory elements of target genes...
  62. ncbi Constitutive NF-kappaB activation by the t(11;18)(q21;q21) product in MALT lymphoma is linked to deregulated ubiquitin ligase activity
    Honglin Zhou
    Molecular Oncology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA
    Cancer Cell 7:425-31. 2005
    ..Thus, t(11;18)(q21;q21) deregulates MALT1/paracaspase ubiquitin ligase activity, causing constitutive NF-kappaB activation and promoting tumorigenesis...
  63. pmc Pericentromeric organization at the fusion point of mouse Robertsonian translocation chromosomes
    S Garagna
    Dipartimento di Biologia Animale, Laboratorio di Biologia dello Sviluppo, Universita degli Studi di Pavia, Piazza Botta 9, 27100 Pavia, Italy
    Proc Natl Acad Sci U S A 98:171-5. 2001
    ..These results are important for an understanding of the geometry of Rb translocations and suggest the study of DNA orientation as a new tool for investigating these rearrangements...
  64. ncbi The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9
    J Borrow
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA
    Nat Genet 12:159-67. 1996
    ..The predicted NUP98-HOXA9 fusion protein may promote leukaemogenesis through inhibition of HOXA9-mediated terminal differentiation and/or aberrant nucleocytoplasmic transport...
  65. pmc Chimeric IgH-TCRalpha/delta translocations in T lymphocytes mediated by RAG
    Elsa Callen
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Cycle 8:2408-12. 2009
    ..We suggest a new model for how oncogenic translocations can arise from two non-concerted physiological DSBs...
  66. pmc A palindrome-mediated mechanism distinguishes translocations involving LCR-B of chromosome 22q11.2
    Anthony L Gotter
    Division of Human Genetics and Molecular Biology, Children s Hospital of Philadelphia, PA 19104, USA
    Hum Mol Genet 13:103-15. 2004
    ..Further analysis suggests that constitutional translocations in general occur between sequences of similar melting temperature and propensity for secondary structure...
  67. pmc Chromosomal translocation and segmental duplication in Cryptococcus neoformans
    James A Fraser
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Eukaryot Cell 4:401-6. 2005
    ..These findings resolve a genome project assembly anomaly and illustrate an example of rapid genome evolution in a fungal genome rich in repetitive elements...
  68. pmc MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation
    Yair Dorsett
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
    Immunity 28:630-8. 2008
    ..A similar but more pronounced translocation phenotype was also found in miR-155-deficient mice. Our experiments indicate that miR-155 can act as a tumor suppressor by reducing potentially oncogenic translocations generated by AID...
  69. doi Benign cartilaginous tumors of bone: from morphology to somatic and germ-line genetics
    Salvatore Romeo
    Department of Pathology, Treviso Regional Hospital, Treviso, Italy
    Adv Anat Pathol 16:307-15. 2009
    ..The main genetic findings are hereby reviewed...
  70. ncbi DNA double-strand break repair and chromosome translocations
    Sheba Agarwal
    Department of Cell Biology and Genetics, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    DNA Repair (Amst) 5:1075-81. 2006
    ..Due to selection at the level of the DNA, the cell, and the tissue certain forms of cancer are associated with specific translocations that can be used as a tool for diagnosis and prognosis of these cancers...
  71. ncbi A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution
    Karl Vandepoele
    Department for Molecular Biomedical Research, VIB Ghent University, Ghent, Belgium
    Mol Biol Evol 22:2265-74. 2005
    ..Overall, this novel NBPF family reflects the continuous evolution of primate genomes that resulted in large physiological differences, and its potential role in this process is discussed...
  72. pmc Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice
    Ai Kotani
    Department of Immunology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 104:1616-20. 2007
    ..Thus, AID may play multiple roles in B cell lymphomagenesis...
  73. ncbi Novel t(5;9)(q33;q22) fuses ITK to SYK in unspecified peripheral T-cell lymphoma
    B Streubel
    Department of Pathology, Medical University of Vienna, Vienna, Austria
    Leukemia 20:313-8. 2006
    ..These results demonstrate the presence of a recurrent t(5;9)(q33;q22) in a subset of unspecified PTCL, which may represent a novel distinct subgroup of PTCL...
  74. ncbi Molecular pathways in follicular lymphoma
    R J Bende
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Leukemia 21:18-29. 2007
    ....
  75. pmc Human subtelomeres are hot spots of interchromosomal recombination and segmental duplication
    Elena V Linardopoulou
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North C3 168, Seattle, Washington 98109, USA
    Nature 437:94-100. 2005
    ..More generally, our analyses suggest an evolutionary cycle between segmental polymorphisms and genome rearrangements...
  76. pmc Stability of large segmental duplications in the yeast genome
    Romain Koszul
    Unité de Génétique Moléculaire des Levures CNRS URA2171, UFR927 Université Pierre et Marie Curie, Département de Structure et Dynamique des Génomes, Institut Pasteur, Paris, 75724 Cedex 15, France
    Genetics 172:2211-22. 2006
    ....
  77. ncbi Genetic abnormalities associated with the t(12;21) and their impact in the outcome of 56 patients with B-precursor acute lymphoblastic leukemia
    Y Alvarez
    Departamento de Biologia Animal, Biología Vegetal y Ecología, Unidad de Antropologia, Facultad de Ciencias, Universidad Autonoma de Barcelona, 08193 Bellaterra Barcelona, Spain
    Cancer Genet Cytogenet 162:21-9. 2005
    ..3 months, secondary abnormalities did not influence patients' outcome. It seems therefore that the prognostic value of the t(12;21) does not vary and that ETV6/RUNX1 rearrangement is an independent indicator of good prognosis...
  78. ncbi The proto-oncoprotein SYT interacts with SYT-interacting protein/co-activator activator (SIP/CoAA), a human nuclear receptor co-activator with similarity to EWS and TLS/FUS family of proteins
    Michela Perani
    Section of Molecular Carcinogenesis, Institute of Cancer Research and Cancer Research UK Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, United Kingdom
    J Biol Chem 280:42863-76. 2005
    ..The stimulation is strongly reduced if the N-terminal region of hBRM/BRG1 (amino acids 1-211) is deleted. This region encompasses the SNF11 binding domain (amino acids 156-211), which interacts specifically with SYT in vivo and in vitro...
  79. pmc AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development
    Makiko Takizawa
    Genomic Integrity and Immunity, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 205:1949-57. 2008
    ..These results thus provide a causality link between the extent of AID enzymatic activity, the number of emerging Igh-cMyc-translocated cells, and the incidence of B cell transformation...
  80. ncbi The role of LMO2 in development and in T cell leukemia after chromosomal translocation or retroviral insertion
    Chang Hoon Nam
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Mol Ther 13:15-25. 2006
    ..In this review, we outline the current knowledge about LMO2 and some possible routes to develop reagents that might be possible macromolecular drugs in the future...
  81. ncbi Translocation (6;17)(q23;q11.2): a novel cytogenetic abnormality in congenital acute myeloid leukemia?
    Elspeth C Ferguson
    Department of Pediatric Haematology and North Trent Cytogenetics Service, Sheffield Children s Hospital, Western Bank, Sheffield S10 2TH, United Kingdom
    Cancer Genet Cytogenet 163:71-3. 2005
    ..These patients generally have a poor prognosis. We present a case of congenital leukemia (AML FAB type M1) with an acquired translocation between chromosomes 6 and 17...
  82. pmc Genetic variation affects de novo translocation frequency
    Takema Kato
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, 1 98 Dengakugakubo, Kutsukake cho, Toyoake Aichi 470 1192, Japan corrected
    Science 311:971. 2006
    ..Alleles with an asymmetric center do not form the t(11;22). Our data show the importance of genome sequence on chromosomal rearrangements, a class of human mutation that is thought to be random...
  83. ncbi [Determination of BCR/ABL translocation in radiation-associated acute myeloid leukemia patients by fluorescence in situ hybridization]
    S V Klymenko
    Tsitol Genet 39:55-9. 2005
    ..BCR/ABL translocation which was detected in 4 and I case respectively may play an important role in radiation-induced leukemigenesis...
  84. ncbi Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocations
    Sonia Franco
    Howard Hughes Medical Institute, The Children s Hospital Boston, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    DNA Repair (Amst) 5:1030-41. 2006
    ..Here, we review recent advances in understanding factors and protein complexes involved in the response to DNA DSBs with a focus on the B lymphocyte specific process of CSR...
  85. ncbi The (epi)genetics of human synovial sarcoma
    Diederik R H de Bruijn
    Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands
    Genes Chromosomes Cancer 46:107-17. 2007
    ..The implications of this model for human synovial sarcoma development and future treatment are discussed...
  86. pmc RAD59 is required for efficient repair of simultaneous double-strand breaks resulting in translocations in Saccharomyces cerevisiae
    Nicholas R Pannunzio
    Division of Molecular Biology, Beckman Research Institute of the City of Hope, 1500 E Duarte Road, Duarte, CA 91010 0269, United States
    DNA Repair (Amst) 7:788-800. 2008
    ..The high frequency of these events suggests that SSA may be an important mechanism of genome rearrangement following acute radiation exposure...
  87. ncbi Antiapoptotic function of apoptosis inhibitor 2-MALT1 fusion protein involved in t(11;18)(q21;q21) mucosa-associated lymphoid tissue lymphoma
    Yoshitaka Hosokawa
    Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Res 64:3452-7. 2004
    ..Thus, our results provide direct experimental evidence that API2-MALT1 can confer resistance to apoptosis, at least in part, by neutralizing apoptosis promoted by Smac...
  88. ncbi A constitutively active SPTBN1-FLT3 fusion in atypical chronic myeloid leukemia is sensitive to tyrosine kinase inhibitors and immunotherapy
    Francis H Grand
    Wessex Regional Genetics Laboratory, University of Southampton, Salisbury, UK
    Exp Hematol 35:1723-7. 2007
    ..To determine the consequences and significance of an acquired 46XX,t(2;13;2;21)(p13;q12;q33;q11.2) in atypical chronic myeloid leukemia (aCML)...
  89. doi E2A-ZNF384 and NOL1-E2A fusion created by a cryptic t(12;19)(p13.3; p13.3) in acute leukemia
    C H Zhong
    Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA
    Leukemia 22:723-9. 2008
    ..This is the first report of expression of E2A fusion protein that includes the DNA binding and protein dimerization domains due to a more proximal break in E2A compared to those described previously...
  90. ncbi AID is required for c-myc/IgH chromosome translocations in vivo
    Almudena R Ramiro
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    Cell 118:431-8. 2004
    ..Here we report that AID is essential for the c-myc/IgH chromosome translocations induced by IL6...
  91. ncbi Characterization of a familial t(16;22) balanced translocation associated with congenital cataract leads to identification of a novel gene, TMEM114, expressed in the lens and disrupted by the translocation
    Robyn V Jamieson
    Academic Unit of Medical Genetics and Regional Genetic Service, University of Manchester, St Mary s Hospital, Manchester, United Kingdom
    Hum Mutat 28:968-77. 2007
    ..Our findings implicate dysregulation of expression of this novel human gene, TMEM114, in mammalian cataract formation...
  92. ncbi IgH class switching and translocations use a robust non-classical end-joining pathway
    Catherine T Yan
    Howard Hughes Medical Institute, of Genetics, Boston, Massachusetts 02115, USA
    Nature 449:478-82. 2007
    ..In the absence of C-NHEJ, this alternative end-joining pathway also frequently joins Igh locus breaks to other chromosomes to generate translocations...
  93. pmc Myc dynamically and preferentially relocates to a transcription factory occupied by Igh
    Cameron S Osborne
    Laboratory of Chromatin and Gene Expression, The Babraham Institute, Cambridge, United Kingdom
    PLoS Biol 5:e192. 2007
    ..Furthermore, the data imply a direct link between the nonrandom interchromosomal organization of transcribed genes at transcription factories and the incidence of specific chromosomal translocations...
  94. doi ETV6/GOT1 fusion in a case of t(10;12)(q24;p13)-positive myelodysplastic syndrome
    Stephanie Struski
    Haematologica 93:467-8. 2008
    ....
  95. ncbi ATM prevents the persistence and propagation of chromosome breaks in lymphocytes
    Elsa Callen
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1360, USA
    Cell 130:63-75. 2007
    ..Silencing this checkpoint permits DNA ends produced by V(D)J recombination in a lymphoid precursor to serve as substrates for translocations with chromosomes subsequently damaged by other means in mature cells...
  96. pmc Reciprocal translocations in Saccharomyces cerevisiae formed by nonhomologous end joining
    Xin Yu
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Genetics 166:741-51. 2004
    ..In some cases the translocation partner is formed by a break at a cryptic HO recognition site. Our results demonstrate that NHEJ-mediated reciprocal translocations can form in S. cerevisiae as a consequence of DSB repair...
  97. ncbi Fluorescence in situ hybridization characterization of different cryptic BCR-ABL rearrangements in chronic myeloid leukemia
    Shaun Haigh
    Institute of Human Genetics, University of Newcastle upon Tyne, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK
    Cancer Genet Cytogenet 155:132-7. 2004
    ..The fourth case also showed evidence of a more complex rearrangement involving chromosome 1...
  98. ncbi NCOA3, a new fusion partner for MOZ/MYST3 in M5 acute myeloid leukemia
    S Esteyries
    Leukemia 22:663-5. 2008
  99. ncbi BCL2 accelerates inflammation-induced BALB/c plasmacytomas and promotes novel tumors with coexisting T(12;15) and T(6;15) translocations
    Santiago Silva
    Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    Cancer Res 63:8656-63. 2003
    ..Accelerated plasmacytomagenesis in strain C.BCL2 may be useful for designing and testing BCL2 inhibition strategies in human plasma cell tumors overexpressing BCL2, such as Waldenström's macroglobulinemia and multiple myeloma...
  100. pmc Smc5-Smc6 complex suppresses gross chromosomal rearrangements mediated by break-induced replications
    Ji Young Hwang
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Bethesda, MD 20892 USA
    DNA Repair (Amst) 7:1426-36. 2008
    ....
  101. pmc Aberrant V(D)J recombination is not required for rapid development of H2ax/p53-deficient thymic lymphomas with clonal translocations
    Craig H Bassing
    Howard Hughes Medical Institute, The Children s Hospital, Center for Blood Research, Institute for Biomedical Research, Department of Genetics, Harvard University Medical School, Boston, MA, USA
    Blood 111:2163-9. 2008
    ..Thus, H2AX is essential for suppressing the transformation of developing thymocytes arising from the aberrant repair of spontaneous DSBs...

Research Grants138 found, 100 shown here

  1. MECHANISMS OF HUMAN LYMPHOID CHROMOSOMAL TRANSLOCATION
    Michael Lieber; Fiscal Year: 2007
    ..Aims 1 through 4 will advance our understanding of chromosomal fragile sites in a general way because the DNA structural principles are likely to apply to other chromosomal fragile sites. ..
  2. MOLECULAR MECHANISMS IN GENE EXPRESSION
    JOAN STEITZ; Fiscal Year: 1980
    ..ribosomes or their subcomponents, RNA processing enzymes, or DNA recognition proteins involved in genetic translocation will then be examined using both chemical and physical techniques...
  3. Chromatin structure maintenance and cancer
    Jianxin You; Fiscal Year: 2010
    ..Brd4 is also a target of the oncogenic Kaposi's sarcoma-associated herpesvirus (KSHV), and the genetic translocation t(15;19) that defines a highly lethal carcinoma...
  4. Risk Factors for Molecularly Defined Subgroups of Lymphoma: A Pooled Analysis
    Brian Chiu; Fiscal Year: 2007
    ..This project directly responds to the NCI strategic plan for cancer preemption because it can elucidate the etiology of NHL. ..
  5. Case-Control Study of Pesticides and t(14;18) Lymphoma
    Brian Chiu; Fiscal Year: 2002
    ..The low-term objective is to improve understanding of the disease process which may ultimately lead to improved prevention of NHL in the general population. ..
  6. Activating liver carcinogens in yeast by expressing CYP450 polymorphisms
    Michael Fasullo; Fiscal Year: 2007
    ..Ultimately, the information will aid public health practitioners and clinicians to identify which individuals are at highest risk for liver cancer, and guide prevention and early detection efforts. ..
  7. Activating liver carcinogens in yeast by expressing CYP450 polymorphisms
    Michael Fasullo; Fiscal Year: 2007
    ....
  8. Full karyotype single cell interphase analysis
    Santiago Munne; Fiscal Year: 2005
    ..In phase-I we propose to develop two of the three sets of probes, and to test that these probes will work with 90% efficiency after three rounds of hybridization in single polar bodies. ..
  9. RADIATION INDUCTION OF GENOMIC REARRANGEMENTS IN YEAST
    Michael Fasullo; Fiscal Year: 2004
    ..abstract_text> ..
  10. HUMAN V(D)J RECOMBINASE IN NEOPLASTIC AND PRIMARY CELLS
    Michael Lieber; Fiscal Year: 2004
    ..Corresponding studies of such regions on minichromosomes will permit the testing of the effects of the direction of DNA replication and transcription. ..
  11. RECOMBINATION MECHANISMS IN YEAST CELL DIFFERENTIATION
    James Haber; Fiscal Year: 2006
    ..abstract_text> ..
  12. NORMAL AND MUTANT LYMPHOID V(D)J RECOMBINASE
    Michael Lieber; Fiscal Year: 2004
    ..Aim 5 utilizes all of these assays to understand human SCID defects due to V(D)J recombination. Aim 6 is directed at continuing our earlier work on chromatin effects on V(D)J recombination. ..
  13. Arrest, Recovery, and Adaptation from DNA Damage
    James Haber; Fiscal Year: 2004
    ..By spreading out the time between the induction of damage and repair, it will be possible to assess the contributions of many checkpoint proteins. ..
  14. Prognostic Models in Diffuse Large B-Cell Lymphoma
    Izidore Lossos; Fiscal Year: 2009
    ..Further, establishment of a paraffin-based RNA prognostic model using the new methodology of RNA extraction could serve as a paradigm for other lymphomas and tumors. ..
  15. GENETIC AND BIOCHEMICAL MECHANISMS OF REGULATION
    James Haber; Fiscal Year: 2007
    ..Funds are requested for 10 predoctoral Trainees. ..
  16. Mechanism and Regulation of Nonhomologous DNA End Joining
    Michael R Lieber; Fiscal Year: 2010
    ..The benefits of some chemotherapy and therapeutic radiation work can be increased by this deeper level of understanding of this key DNA repair pathway. ..
  17. NORMAL AND MUTANT LYMPHOID V(D)J RECOMBINASE
    Michael R Lieber; Fiscal Year: 2010
    ..In the long-term, all of these studies will help establish optimal therapy for many human SCID patients and to understand the human immune repertoire. ..
  18. Significance and Function of HGAL in Lymphoma
    Izidore S Lossos; Fiscal Year: 2010
    ..These findings will not only elucidate the mechanisms of tumor dissemination but also will identify a new potential molecular target for novel therapeutic intervention. ..
  19. MECHANISM OF DNA RECOMBINATION AT CLASS SWITCH SEQUENCES
    Michael R Lieber; Fiscal Year: 2010
    ..Hence, this proposal tests in vivo substrate structure, its mechanism of formation, the action of AID enzyme on that structure, and the pathway for rejoining the ends after breakage has occurred. ..
  20. Arrest, Recovery, and Adaptation from DNA Damage
    James Haber; Fiscal Year: 2009
    ..Hence, it is important to study the DCC in budding yeast, where the fate of broken DNA and the recruitment of DNA damage-responsive proteins can be studied in great detail. ..
  21. Significance and Function of HGAL in Lymphoma
    Izidore Lossos; Fiscal Year: 2009
    ..These findings will not only elucidate the mechanisms of tumor dissemination but also will identify a new potential molecular target for novel therapeutic intervention. ..
  22. Prognostic Models in Diffuse Large B-Cell Lymphoma
    Izidore S Lossos; Fiscal Year: 2010
    ..Further, establishment of a paraffin-based RNA prognostic model using the new methodology of RNA extraction could serve as a paradigm for other lymphomas and tumors. ..
  23. NORMAL AND MUTANT LYMPHOID V(D)J RECOMBINASE
    Michael Lieber; Fiscal Year: 2009
    ..In the long-term, all of these studies will help establish optimal therapy for many human SCID patients and to understand the human immune repertoire. ..
  24. Prognostic Models in Diffuse Large B-Cell Lymphoma
    Izidore Lossos; Fiscal Year: 2007
    ..Further, establishment of a paraffin-based RNA prognostic model using the new methodology of RNA extraction could serve as a paradigm for other lymphomas and tumors. ..
  25. MECHANISM OF DNA RECOMBINATION AT CLASS SWITCH SEQUENCES
    Michael Lieber; Fiscal Year: 2009
    ..Hence, this proposal tests in vivo substrate structure, its mechanism of formation, the action of AID enzyme on that structure, and the pathway for rejoining the ends after breakage has occurred. ..
  26. RECOMBINATION MECHANISMS IN YEAST CELL DIFFERENTIATION
    James Haber; Fiscal Year: 2007
    ..Cis-acting sequences that constrain the left arm of chromosome III, including HML, will be identified. Rapid light microscopy will also be used to analyze the constraints on chromosome movement regulated by RE. ..
  27. MECHANISM AND REGULATION OF NONHOMOLOGOUS DNA ENDJOINING
    Michael Lieber; Fiscal Year: 2007
    ..The long-term medical benefit of a biochemically-defined NHEJ system includes the ability to test small molecule drug inhibitors for roles in cancer therapy. ..
  28. Significance and Function of HGAL in Lymphoma
    Izidore S Lossos; Fiscal Year: 2010
    ..These findings will not only elucidate the mechanisms of tumor dissemination but also will identify a new potential molecular target for novel therapeutic intervention. ..
  29. CONTROL OF CELL TYPE AND GAMETOGENESIS
    James Haber; Fiscal Year: 1990
    ..Preliminary experiments have suggested that these mutations affect a network of genes that affect protein synthesis, amino acid biosynthesis and cell cycle arrest...
  30. RECOMBINATION MECHANISMS IN YEAST CELL DIFFERENTIATION
    James Haber; Fiscal Year: 1993
    ..The way in which these distant sequences can be brought together for recombination may shed light on similar events in the generation of human immunoglobulin gene rearrangements...
  31. MECHANISM OF DNA RECOMBINATION AT CLASS SWITCH SEQUENCES
    Michael Lieber; Fiscal Year: 2001
    ..Fifth, we search for enzymatic activities in extracts that carry out the cleavage step in class switch recombination. ..
  32. HUMAN V(D)J RECOMBINASE IN NEOPLASTIC AND PRIMARY CELLS
    Michael Lieber; Fiscal Year: 1999
    ....
  33. The Role of MLL-AF9 in Acute Myeloid Leukemia
    James C Mulloy; Fiscal Year: 2010
    ..RELEVANCE (See instructions): We have recently shown that human blood stem cells can be induced to make leukemia upon introduction ..
  34. Moderators and Outcomes in Children With Mild to Severe Hearing Impairment
    JAMES BRUCE contact TOMBLIN; Fiscal Year: 2010
    ..These data will, therefore, form the foundation for evidenced based practice and policy for the clinical management of children with hearing loss. ..
  35. The Genetics of Specific Language Impairment
    JAMES TOMBLIN; Fiscal Year: 2009
    ..The phenotypes and endophenotypes from these individuals will then be used in conjunction with the existing genotyping for additional genome-wide screens and further follow-up fine mapping studies. ..
  36. STUDIES OF CHILDHOOD SOLID TUMORS
    Peter Houghton; Fiscal Year: 2007
    ..Our intent remains to advance preclinical information to the design of clinical trials, and extend these to cooperative groups. ..
  37. BAC-FISH Assays for Sensitive Karyotyping of Cancer Cells
    Heinz Ulrich Weier; Fiscal Year: 2007
    ....
  38. RADIATION-INDUCED THYROID CANCER
    Heinz Ulrich G Weier; Fiscal Year: 2010
    ..We expect this research to lead to improved control of PTC with regard to early disease detection and better disease management and, thus, to enhance public health services. ..
  39. The Genetics of Specific Language Impairment
    JAMES TOMBLIN; Fiscal Year: 2009
    ..The phenotypes and endophenotypes from these individuals will then be used in conjunction with the existing genotyping for additional genome-wide screens and further follow-up fine mapping studies. ..
  40. Aneuploid Cells in the Human Placenta
    Heinz Ulrich Weier; Fiscal Year: 2006
    ..We will also have detailed information about the frequency, localization and types of aneuploid cells at the fetal-maternal interface and the effects of aneuploidy on CTB proliferation and HLA-G gene expression. ..
  41. RADIATION INDUCED THYROID CANCER
    Heinz Ulrich Weier; Fiscal Year: 2002
    ..We will prepare stable cell lines carrying the oncogenic rearrangements for further characterization and distribution. Finally, we will examine the levels and localization of mRNAs with Northern and in situ hybridization analysis. ..
  42. Collaboration on Specific Language Impairment
    JAMES TOMBLIN; Fiscal Year: 2005
    ..abstract_text> ..
  43. The Role of CBFb-MYH11 in Acute Myeloid Leukemia
    James C Mulloy; Fiscal Year: 2010
    ..To identify specific signals that will cooperate in the transformation to acute leukemia, defined eenetic elements and saturatine retroviral mutaeenesis will be used. ..
  44. MECHANISM OF DNA RECOMBINATION AT CLASS SWITCH SEQUENCES
    Michael Lieber; Fiscal Year: 2005
    ..Hence, this proposal tests in vivo substrate structure, its mechanism of formation, the action of AID enzyme on that structure, and the pathway for rejoining the ends after breakage has occurred. ..
  45. MTG-16 Regulation by Phosphorylation
    Michael Engel; Fiscal Year: 2006
    ..Ultimately, the goal is to ascertain the effect of specific phosphorylation events on growth, transformation and development. These data may have future therapeutic implications for diverse cancer types. ..