Genomes and Genes
Summary: Pathological processes consisting of the union of the opposing surfaces of a wound.
Publications255 found, 100 shown here
- Consequences and complications of peritoneal adhesionsH van Goor
Department of Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Colorectal Dis 9:25-34. 2007..b>Adhesions to the ventral abdominal wall are responsible for the majority of trocar injuries...
- Molecular characterization of postoperative adhesions: the adhesion phenotypeGhassan M Saed
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA
J Am Assoc Gynecol Laparosc 11:307-14. 2004..To date, approaches to limit adhesions primarily have involved barriers to separate tissue during reepithelization...
- Prevention of adhesions by bioresorbable tissue barrier following laparoscopic intraabdominal mesh insertionM Mahir Ozmen
Department of Surgery and Pathology, Ankara Numune Teaching and Research Hospital, Turkey
Surg Laparosc Endosc Percutan Tech 12:342-6. 2002Intraabdominal adhesions represent a significant problem because of the morbidity associated with adhesive disease, including small bowel obstruction, difficulties in reoperative surgery, and possibly chronic pain...
- Prevention of peritoneal adhesions by intraperitoneal administration of vitamin E: an experimental study in ratsFernando de la Portilla
Coloproctology Unit, Department of General Surgery, Hospital Juan Ramon Jimenez, Huelva, Spain
Dis Colon Rectum 47:2157-61. 2004Previous studies have shown dietary supplements of vitamin E to reduce the incidence of postoperative peritoneal adhesions. The objective of this study was to show the effect of intramuscular or intraperitoneal administration of vitamin ..
- Prevention of postsurgery-induced abdominal adhesions by electrospun bioabsorbable nanofibrous poly(lactide-co-glycolide)-based membranesXinhua Zong
Department of Chemistry, Stony Brook University, Stony Brook, New York 11794 3400, USA
Ann Surg 240:910-5. 2004The objective of this study was to evaluate the efficacy of nonwoven bioabsorbable nanofibrous membranes of poly(lactideco-glycolide) for prevention of postsurgery-induced abdominal adhesions.
- Fewer adhesions induced by laparoscopic surgery?C N Gutt
Department of General, Visceral and Trauma Surgery, Ruprecht Karls University, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
Surg Endosc 18:898-906. 2004..Laparoscopic surgery has potential theoretical advantages over open surgery in reducing the rate of adhesion formation, but very few comparative studies are available to prove this...
- Population-based study of the surgical workload and economic impact of bowel obstruction caused by postoperative adhesionsJ Kössi
Department of Surgery, University of Turku, Turku, Finland
Br J Surg 90:1441-4. 2003Intestinal obstruction is the most severe consequence of adhesion formation. This study examined the annual surgical workload and costs of intestinal obstruction caused by postoperative intra-abdominal adhesions.
- Macrophage and T-lymphocyte infiltrates in human peritoneal adhesions indicate a chronic inflammatory diseaseMarcel Binnebösel
Department of Surgery, RWTH Aachen University Hospital, Pauwelsstr 30, 52074, Aachen, Germany
World J Surg 32:296-304. 2008Peritoneal adhesions are common and lead to significant clinical morbidity and mortality. Besides various individual factors, notably the inflammatory response to peritoneal defects affects adhesion formation...
- In situ cross-linkable hyaluronan hydrogels containing polymeric nanoparticles for preventing postsurgical adhesionsYoon Yeo
Department of Chemical Engineering and Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA
Ann Surg 245:819-24. 2007..barrier method and drug delivery system ("hybrid system") for preventing postoperative peritoneal adhesions, which could combine the biocompatibility and ease of application of in situ cross-linkable hydrogels with the ..
- In vivo performance of antibiotic embedded electrospun PCL membranes for prevention of abdominal adhesionsN Bolgen
Chemical Engineering Department and Bioengineering Division and TUBITAK USAM Biyomedtek, Hacettepe University, Beytepe, Ankara, Turkey
J Biomed Mater Res B Appl Biomater 81:530-43. 2007..PCL) and their antibiotic containing forms by electrospinning, so as to prevent postsurgery induced abdominal adhesions in rats...
- Surgical adhesions: a timely update, a great challenge for the futureAndrew K Davey
Sansom Institute, University of South Australia, Adelaide, South Australia
J Minim Invasive Gynecol 14:15-22. 2007..While these strategies have provided some success, none have yet proved totally successful in abolishing adhesions. Further research to ensure that adhesion prevention is optimal is therefore essential.
- A comparison of two adjunctive treatments for intrauterine adhesions following lysisA A E Orhue
Human Reproduction Research Programme, Unit Department of Obstetrics and Gynaecology, University of Benin Teaching Hospital, Benin City, Edo State, Nigeria
Int J Gynaecol Obstet 82:49-56. 2003..To assess which treatment modality has a better outcome: the use of an intrauterine contraceptive device or the Foley catheter balloon, for the adjunctive treatment of intrauterine adhesion (IUA) in patients presenting with infertility...
- Reduction of neural adhesions by biodegradable autocrosslinked hyaluronic acid gel after injury of peripheral nerves: an experimental studyXander Smit
Department of Plastic and Reconstructive Surgery, Erasmus MC University Medical Center Rotterdam, The Netherlands
J Neurosurg 101:648-52. 2004..The authors aimed to develop an objective biomechanical method of quantifying nerve adhesions and to use this technique for the evaluation of the efficacy of an autocrosslinked hyaluronic acid (HA) gel as ..
- Prevention of peritendinous adhesions using a hyaluronan-derived hydrogel film following partial-thickness flexor tendon injuryYanchun Liu
Center for Therapeutic Biomaterials and Department of Medicinal Chemistry, The University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, Utah 84108 1257, USA
J Orthop Res 26:562-9. 2008Peritendinous adhesions are an important complication of flexor tendon injury. Three hyaluronan (HA)-derived biomaterials were evaluated for the reduction of peritendinous adhesions following partial-thickness tendon injury in rabbits...
- The effects of anti-adhesion materials in preventing postoperative adhesion in abdominal cavity (anti-adhesion materials for postoperative adhesions)Mustafa Sahin
Department of General Surgery, Selcuk University Meram Medical Faculty, Konya, Turkey
Inflammation 30:244-9. 2007The purpose of this study was to compare the effects of anti-adhesion materials in postoperative adhesions.
- Comparative effectiveness of several agents for preventing postoperative adhesionsJehat Kutlay
2nd General Surgery Department, SSK Ankara Teaching Hospital, Ankara 06090, Turkey
World J Surg 28:662-5. 2004Postoperative adhesions (PAs) are usually clinically asymptomatic...
- In situ cross-linkable hyaluronic acid hydrogels prevent post-operative abdominal adhesions in a rabbit modelYoon Yeo
Department of Chemical Engineering, 77 Massachusetts Avenue, Massachusetts Institute of Technology, Cambridge, 02139, USA
Biomaterials 27:4698-705. 2006..the efficacy of an in situ cross-linked hyaluronic acid hydrogel (HAX) in preventing post-surgical peritoneal adhesions, using a rabbit sidewall defect-cecum abrasion model...
- Modulation of the expression of tissue plasminogen activator and its inhibitor by hypoxia in human peritoneal and adhesion fibroblastsGhassan M Saed
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, and the C S Mott Center for Human Growth and Development, Wayne State University, Detroit, Michigan 48201, USA
Fertil Steril 79:164-8. 2003..To determine whether normal peritoneal and adhesion fibroblasts express tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI-I) and whether their expression is regulated by oxygen...
- Adhesions in a murine flexor tendon graft model: autograft versus allograft reconstructionSys Hasslund
The Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA
J Orthop Res 26:824-33. 2008Reconstruction of flexor tendons often results in adhesions that compromise joint flexion. Little is known about the factors involved in the formation of flexor tendon graft adhesions...
- Intrauterine adhesions after conservative and surgical management of spontaneous abortionWing Hung Tam
Department of Obstetrics and Gynaecology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
J Am Assoc Gynecol Laparosc 9:182-5. 2002To determine the frequency of intrauterine adhesions (IUA) after conservative management, medical evacuation, and surgical evacuation for spontaneous abortion.
- Prevention of abdominal adhesions--present state and what's beyond the horizon?B Tingstedt
Department of Surgery, Lund University, Lund, Sweden
Eur Surg Res 39:259-68. 2007Intra-abdominal adhesions are normally found after most surgical procedures...
- Evaluation of hyaluronic acid sheet for the prevention of postlaminectomy adhesionsTsuyoshi Kato
Department of Spinal and Orthopaedic Surgery, Tokyo Medical and Dental University, Graduate School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 5819, Japan
Spine J 5:479-88. 2005..Hyaluronic acid (HA) solution and gel have been reported to be effective in preventing adhesions postlaminectomy; however, neither has been used clinically after spinal surgery.
- Inhibition of CCL1-CCR8 interaction prevents aggregation of macrophages and development of peritoneal adhesionsAkiyoshi Hoshino
Department of Medical Ecology and Informatics, International Medical Center of Japan, Tokyo, Japan
J Immunol 178:5296-304. 2007Peritoneal adhesions are a significant complication of surgery and visceral inflammation; however, the mechanism has not been fully elucidated...
- Prevention of peritendinous adhesions following flexor tendon injury with seprafilmAdnan Menderes
Dokuz Eylul University, Faculty of Medicine, Department of Plastic, Reconstructive and Aesthetic Surgery, Izmir, Turkey
Ann Plast Surg 53:560-4. 2004Peritendinous adhesions are the most important complication of flexor tendon injury. In this study, Seprafilm was used for the prevention of peritendinous adhesions following flexor tendon repair...
- Abdominal adhesions: intestinal obstruction, pain, and infertilityW W Vrijland
Department of Gynecology, Erasmus Medical Center, Dr Molewaterplein 40, 3015 CD Rotterdam, The Netherlands
Surg Endosc 17:1017-22. 2003b>Adhesions cause bowel obstruction, chronic abdominal pain, and infertility. In this review, the incidence, clinical signs, diagnostic procedures, and treatment of these sequels of abdominal surgery are discussed...
- A randomized, controlled pilot study of the safety and efficacy of 4% icodextrin solution in the reduction of adhesions following laparoscopic gynaecological surgeryG S diZerega
University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Hum Reprod 17:1031-8. 2002Adhesion-related readmissions are frequent sequelae to gynaecological surgery. Attempts to prevent adhesions by separating healing peritoneal surfaces include site-specific barriers and hydroflotation by instilled solutions...
- Adhesion-related readmissions following gynaecological laparoscopy or laparotomy in Scotland: an epidemiological study of 24 046 patientsA M Lower
Isis Fertility Centre, Colchester CO4 9YA, UK
Hum Reprod 19:1877-85. 2004..This study evaluated the epidemiology of adhesion-related readmissions following open and laparoscopic procedures...
- Identification of adhesions on CT in small-bowel obstructionBojan Petrovic
Department of Radiology, Northwestern University Feinberg School of Medicine, Suite 800, 676 N Saint Clair Street, Chicago, IL 60611, USA
Emerg Radiol 12:88-93; discussion 94-5. 2006Identification of adhesions on computed tomography (CT) in cases of small-bowel obstruction (SBO) is currently a diagnosis of exclusion...
- Reproductive outcome following treatment of intrauterine adhesions in Abuja, NigeriaE R Efetie
Department of Obstetrics and Gynaecology National Hospital Abuja, Nigeria
Niger J Clin Pract 9:164-8. 2006..Both of these problems are sometimes traced to intrauterine adhesions (IUA) which is preventable in the majority of cases...
- Inhibition of chemokines prevents intraperitoneal adhesions in miceMurat Berkkanoglu
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
Hum Reprod 20:3047-52. 2005..The present study evaluates the efficacy of a broad-spectrum chemokine inhibitor, NR58-3.14.3, in the prevention of adhesion formation after i.p. surgery in mice...
- Anomalous vitreoretinal adhesions in patients with exudative age-related macular degeneration: an OCT studyM Quaranta-El Maftouhi
Centre Ophtalmologique Rabelais, Lyon, France
Eur J Ophthalmol 16:134-7. 2006..To analyze the relationship between the retina and the vitreous in patients with exudative age-related macular degeneration (ARMD)...
- Efficacy of bioactive polypeptides on bleeding and intra-abdominal adhesionsBobby Tingstedt
Department of Surgery and Physical Chemistry 1, Centre of Chemistry, Lund University, Lund, Sweden
Eur Surg Res 39:35-40. 2007Perioperative bleeding and postoperative adhesions are two problems encountered in abdominal surgery...
- Development of peritoneal adhesions in macrophage depleted miceSandra H Burnett
Department of Microbiology and Molecular Biology, Brigham Young University, Provo, Utah 84602, USA
J Surg Res 131:296-301. 2006BACKGROUND: We present a new mouse model for the study of peritoneal adhesions using macrophage Fas-induced apoptosis (Mafia) transgenic mice expressing a Fas-FKBP construct under control of the murine c-fms promoter...
- Cyclooxygenase-2 is expressed in human fibroblasts isolated from intraperitoneal adhesions but not from normal peritoneal tissuesGhassan M Saed
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Detroit, Michigan 48201, USA
Fertil Steril 79:1404-8. 2003..To determine whether the COX-2 gene is expressed in human fibroblasts isolated from normal peritoneal and adhesion tissues...
- Use of transabdominal ultrasound to identify intraabdominal adhesions prior to laparoscopy: a prospective blinded studyShanu N Kothari
Minimally Invasive Bariatric Surgery Clinic, Gundersen Lutheran Medical Center, La Crosse, WI, USA
Am J Surg 192:843-7. 2006The aim of the current study was to assess the accuracy of transabdominal ultrasound (TAU) in identifying intra-abdominal adhesions (IAA) prior to laparoscopy in patients with previous abdominal surgery.
- Peritoneal effects of prosthetic meshes used to repair abdominal wall defects: monitoring adhesions by sequential laparoscopyJuan M Bellon
Department of Surgery, Alcala University, Madrid, Spain
J Laparoendosc Adv Surg Tech A 17:160-6. 2007..This interface is often a site of complications such as intestinal obstruction or fistulas due to adhesions. The aim of this study was to follow the process of adhesion formation in several prosthetic materials by ..
- Differently charged polypeptides in the prevention of post-surgical peritoneal adhesionsLaszlo Nehez
Department of Surgery, Lund University Hospital, SE 221 85 Lund, Sweden
Scand J Gastroenterol 42:519-23. 2007Peritoneal adhesions develop after almost all surgical interventions in the abdomen...
- Prevention of postoperative peritoneal adhesions: effects of lysozyme, polylysine and polyglutamate versus hyaluronic acidLaszlo Nehez
Department of Surgery, Lund University, Sweden
Scand J Gastroenterol 40:1118-23. 2005Intraperitoneal adhesions are an important cause of postoperative intestinal obstruction, abdominal discomfort and infertility...
- Seprafilm (modified hyaluronic acid and carboxymethylcellulose) acts as a physical barrierL April Gago
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA
Fertil Steril 80:612-6. 2003..To characterize the molecular changes that occur in normal fibroblasts, adhesion fibroblasts, and mesothelial cells as a result of exposure to modified hyaluronic acid and carboxymethylcellulose (Seprafilm)...
- Intra-uterine adhesions and fertility outcome: how to optimize success?Pinar H Kodaman
Yale University School of Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Section of Reproductive Endocrinology and Infertility, New Haven, Connecticut 06520, USA
Curr Opin Obstet Gynecol 19:207-14. 2007To review the etiology, diagnosis, and clinical manifestations of intra-uterine adhesions and to address treatment with a specific focus on fertility outcome.
- Medicolegal consequences of adhesionsHarold Ellis
Division of Anatomy, Guy s, King s and St Thomas School of Biomedical Science, London SE1 1UL
Hosp Med 65:348-50. 2004Postoperative intra-abdominal adhesions are an almost invariable consequence of abdominal and pelvic surgery...
- RNA interference targeting hypoxia inducible factor 1alpha reduces post-operative adhesions in ratsTatiana Segura
Ecole Polytechnique Federale de Lausanne EPFL, Institute of Bioengineering and Institute of Chemical Sciences and Engineering, Lausanne, Switzerland
J Surg Res 141:162-70. 2007..To investigate the use of RNA interference mediated gene down-regulation targeting hypoxia inducible factor 1alpha (HIF-1alpha) and plasminogen activator inhibitor 1 (PAI-1) in an effort to prevent abdominal adhesion formation...
- Pain mapping of adhesionsLarry Demco
University of Calgary, Calgary, Alberta, Canada
J Am Assoc Gynecol Laparosc 11:181-3. 2004To determine the nature and location of adhesions and their relationship to abdominal pain in patients undergoing awake microlaparoscopy.
- Transplantation of an autologous mesothelial cell sheet prepared from tunica vaginalis prevents post-operative adhesions in a canine modelTouko Asano
Department of Urology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Tissue Eng 12:2629-37. 2006Post-operative adhesions often cause severe complications such as bowel obstruction and abdominopelvic pain. Previously, we reported that transplantation of a mesothelial cell sheet is effective for preventing adhesion in rat model...
- Adhesions and colorectal surgery - call for actionM C Parker
Darent Valley Hospital, Dartford, Kent, UK
Colorectal Dis 9:66-72. 2007Mounting evidence highlights that adhesions are now the most frequent complication of abdominopelvic surgery, yet many surgeons are still not aware of the extent of the problem and its serious consequences...
- Intraperitoneal administration of adenosine inhibits formation of abdominal adhesionsEdwin K Jackson
Center for Clinical Pharmacology, Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Dis Colon Rectum 47:1390-6. 2004..fibroblast proliferation and collagen production and inflammation and enhances angiogenesis, we tested the hypothesis that adenosine applied into the abdominal cavity safely and effectively reduces formation of abdominal adhesions.
- Paclitaxel-loaded crosslinked hyaluronic acid films for the prevention of postsurgical adhesionsJohn K Jackson
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada
Pharm Res 19:411-7. 2002....
- Omentum prevents intestinal adhesions to mesh graft in abdominal infections and serosal defectsB Karabulut
Department of Pediatric Surgery, Gazi University, Faculty of Medicine, Ankara, Turkey
Surg Endosc 20:978-82. 2006..In this study, the effects resulting from the presence or absence of the omentum were evaluated in the setting of infection or serosal defects in the formation of adhesions in abdominal closures using mesh grafts.
- Human peritoneal adhesions show evidence of tissue remodeling and markers of angiogenesisJonathan C Epstein
Faculty of Life Sciences, The University of Manchester, and Department of Surgery, Christie Hospital, Manchester, M13 9PT, United Kingdom
Dis Colon Rectum 49:1885-92. 2006This study was designed to investigate the vascular structure and angiogenic activity of human peritoneal adhesions.
- Amnion graft following hysteroscopic lysis of intrauterine adhesionsMohamed I Amer
Department of Obstetrics and Gynecology, Ain Shams University, Cairo, Egypt
J Obstet Gynaecol Res 32:559-66. 2006To evaluate the safety and efficacy of amnion grafting after hysteroscopic lysis of intrauterine adhesions.
- Collagen foil (TissuFoil E) reduces the formation of adhesions when using polypropylene mesh for the repair of experimental abdominal wall defectsFrank Schönleben
Chirurgische Klinik mit Poliklinik der Universität Erlangen Nürnberg, Krankenhausstr 12, 91054 Erlangen, Germany
Int J Colorectal Dis 21:840-6. 2006..Severe adhesions are a common cause of intestinal obstruction, or even intestinal fistulas...
- Transvaginal three-dimensional ultrasonography combined with serum CA 125 level for the diagnosis of pelvic adhesions before laparoscopic surgeryKok Min Seow
Department of Obstetrics and Gynecology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
J Am Assoc Gynecol Laparosc 10:320-6. 2003To investigate the role of transvaginal three-dimensional ultrasonography combined with serum CA 125 level in diagnosing pelvic adhesions before scheduled laparoscopic surgery.
- Interosseous-lumbrical adhesions of the hand: contribution of magnetic resonance imaging to diagnosis and treatment planningVirak Tan
Division of Hand and Microsurgery, University of Medicine and Dentistry of New Jersey NJ Medical School, 90 Bergen Street, DOC Suite 5200, Newark, NJ 07103, USA
J Hand Surg Am 27:639-43. 2002..have not found magnetic resonance imaging (MRI) to be helpful in the diagnosis of interosseous-lumbrical tendon adhesions of the hand...
- Peritoneal adhesions: pathogenesis, assessment and effectsM P Senthilkumar
Department of Surgery, Dumfries and Galloway Royal Infirmary, Dumfries, UK
Trop Gastroenterol 27:11-8. 2006As modem surgery has evolved, there has been an increase in iatrogenic peritoneal adhesions. Most surgeons manage adhesions and their related complications on a regular basis...
- Reduction of postoperative adhesions by N,O-carboxymethylchitosan and spermine NONOate in ratsBulent Duran
Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey
Exp Anim 52:267-72. 2003Postsurgical adhesions can occur following virtually all types of surgery, resulting in serious clinical complications. Therefore, prevention of adhesions is an important goal of surgical practice...
- The effect of Seprafilm on adhesions in strabismus surgery-an experimental studySeyhan B Ozkan
Department of Ophthalmology, Adnan Menderes University Medical School, Aydm, Turkey
J AAPOS 8:46-9. 2004..b>Adhesions occurring after strabismus surgery may affect surgical outcome...
- Expression of transforming growth factor-beta and extracellular matrix by human peritoneal mesothelial cells and by fibroblasts from normal peritoneum and adhesions: effect of TisseelGhassan M Saed
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University Detroit Medical Center, Hutzel Hospital, 4707 St Antoine Boulevard, Detroit, MI 48201, USA
Wound Repair Regen 12:557-64. 2004We have previously shown that fibroblasts obtained from adhesions produce greater amounts of transforming growth factor-beta 1 (TGF-beta1) and extracellular matrix (ECM) molecules than normal fibroblasts isolated from normal peritoneum...
- The prevalence of interstitial cystitis, endometriosis, adhesions, and vulvar pain in women with chronic pelvic painEdward J Stanford
Department of Urogynecology Obstetrics and Gynecology, St Mary s Good Samaritan Hospital, Centralia, Illinois 62801, USA
J Minim Invasive Gynecol 12:43-9. 2005..To estimate the prevalence of bladder-origin pain, intraperitoneal pathology, and vulvar pain in patients undergoing laparoscopy for chronic pelvic pain (CPP)...
- Reduction of adhesions with composite AlloDerm/polypropylene mesh implants for abdominal wall reconstructionCharles E Butler
Department of Plastic Surgery, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
Plast Reconstr Surg 114:464-73. 2004..includes the use of structural prosthetic materials, such as polypropylene mesh, that can induce dense abdominal adhesions to peritoneal structures. AlloDerm (LifeCell Corp., Branchburg, N.J...
- Use of a high-molecular-weight carboxymethylcellulose in a tissue protective solution for prevention of postoperative abdominal adhesions in poniesDavid J Murphy
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610, USA
Am J Vet Res 63:1448-54. 2002To evaluate efficacy and safety of IP administration of high-molecular-weight carboxymethylcellulose (HMW CMC) for the prevention of postoperative intra-abdominal adhesions in ponies.
- Peritoneal fluid concentrations of matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and transforming growth factor-beta in women with pelvic adhesionsYing C Cheong
Department of Obstetrics and Gynaecology, St Mary s Hospital, Milton Road, Portsmouth, Hampshire, United Kingdom
Fertil Steril 79:1168-75. 2003..tissue inhibitor of metalloproteinase-1 (TIMP-1), and transforming growth factor-beta (TGF-beta) is influenced by the presence or absence of adhesions, and whether the concentration of these mediators vary throughout the menstrual cycle.
- Clinical evaluation of a viscoelastic gel for reduction of adhesions following gynaecological surgery by laparoscopy in EuropeP Lundorff
Department of Obstetrics and Gynecology, Viborg Hospital, Viborg, Denmark
Hum Reprod 20:514-20. 2005..Commonly used adhesion prevention devices either cannot be applied or are difficult to use via laparoscopy. A viscoelastic gel was developed specifically for adhesion prophylaxis during minimally invasive surgery...
- Adhesion formation after laparoscopic excision of endometriosis and lysis of adhesionsJason D Parker
National Institutes of Health, Bethesda, MD, USA
Fertil Steril 84:1457-61. 2005..To evaluate adhesion reformation after laparoscopic excision of endometriosis and adhesiolysis in women with chronic pelvic pain...
- Role of fibrin glue in the prevention of peritoneal adhesions in ventral hernia repairJuan Antonio Martín-Cartes
Surgical Department, Laparoscopic Surgery Unit, Virgen del Rocio University Hospital, c Baños 76, 41002, Seville, Spain
Surg Today 38:135-40. 2008..The aim of this study was to investigate the effects of fibrin glue on the prevention of postoperative peritoneal adhesion to prosthetic materials used in ventral hernia repair...
- Apoptosis and proliferation of human peritoneal fibroblasts in response to hypoxiaGhassan M Saed
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, and the C S Mott Center for Human Growth and Development, Wayne State University, Detroit, Michigan 48201, USA
Fertil Steril 78:137-43. 2002To determine the effect of hypoxia on apoptosis and proliferation of fibroblasts cultured from normal peritoneum or adhesions.
- Comparison of two laparoscopic treatments for experimentally induced abdominal adhesions in pony foalsJennifer L Lansdowne
Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Canada
Am J Vet Res 65:681-6. 2004To compare laparoscopic dissection with-laparoscopic dissection combined with abdominal instillation of ferric hyaluronate gel for the treatment of experimentally induced adhesions in pony foals.
- Female infertility and free radicals: potential role in adhesions and endometriosisZeynep Alpay
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, C S Mott Center for Human Growth and Development, Wayne State University, Detroit, Michigan 48201, USA
J Soc Gynecol Investig 13:390-8. 2006..Peritoneal adhesions and endometriosis are relatively commonly identified in women, and are known to be associated with infertility ..
- Special techniques in pain management: lysis of adhesionsCarlos O Viesca
Texas Tech University Health Sciences Center, 3601 4th Street, Room 1C 282, Lubbock, TX 79430, USA
Anesthesiol Clin North America 21:745-66, vi. 2003..To enhance treatment outcome, an understanding of the pathophysiology of the underlying pain and the design of target-specific treatment modalities is important...
- Prevention of gynaecological adhesions using haemostatic fleece in a rabbit modelG Dickneite
ZLB Behring GmbH, Marburg, Germany
J Int Med Res 34:505-13. 2006..After 14 days, the animals were killed and examined for the presence of adhesion. The lengths of any adhesions were measured and the severity was recorded as a score (0, no adhesion; 1, adhesion easy to lyse; 2, adhesion ..
- Complications and feasibility of laparoscopic adhesiolysis in patients with chronic abdominal pain. A retrospective studyD J Swank
Department of Surgery, Groene Hart Hospital, Gouda, PO Box 1098, 2800 BB Gouda, The Netherlands
Surg Endosc 16:1468-73. 2002..A retrospective study was done to determine whether laparoscopic adhesiolysis benefits patients with chronic abdominal pain. Factors that influence complications and feasibility of laparoscopic adhesiolysis were evaluated...
- Evaluation of laparoscopic adhesiolysis for the treatment of experimentally induced adhesions in pony foalsLudovic P Boure
Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Canada
Am J Vet Res 63:289-94. 2002To assess the efficacy of laparoscopic adhesiolysis in the treatment of experimentally induced adhesions in foals.
- Complete hypopharyngeal obstruction by mucosal adhesions: a complication of intensive chemoradiation for advanced head and neck cancerElizabeth J Franzmann
Department of Otolaryngology, University of Miami Sylvester Comprehensive Cancer Center, 1475 NW 12th Avenue, Suite 4037, Miami, FL 33136, USA
Head Neck 28:663-70. 2006..seen with complete obstruction of the hypopharynx distal to the site of the primary cancer, and in whom we postulate that the obstruction was caused by separable mucosal adhesions rather than obliteration by a mature fibrous stricture.
- Bowel injury as a complication of laparoscopyM van der Voort
Department of Surgery, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
Br J Surg 91:1253-8. 2004..Bowel injury is a rare but serious complication of laparoscopic surgery. This review examines the incidence, location, time of diagnosis, causative instruments, management and mortality of laparoscopy-induced bowel injury...
- Two experimental models for generating abdominal adhesionsWolfgang B Gaertner
Department of Surgery, University of Minnesota, 420 Delaware St SE, MMC 195, Minneapolis, MN 55455, USA
J Surg Res 146:241-5. 2008To develop dependable rat models for generating abdominal adhesions that allow for objective evaluation and quantification.
- Adhesions caused by umbilical piercingGary Ventolini
Department of Obstetrics and Gynecology, Good Samaritan Hospital, Cincinnati, OH, USA
J Am Assoc Gynecol Laparosc 10:281. 2003..Diagnostic laparoscopy revealed an umbilical adhesion from the small bowel to the anterior abdominal wall. The patient removed the umbilical piercing but declined surgery for adhesiolysis...
- The preventive effect of Rofecoxib in postoperative intraperitoneal adhesionsM Aldemir
Department of General Surgery, Dicle University, Faculty of Medicine, Diyarbakir, Turkey
Acta Chir Belg 104:97-100. 2004..Therefore, we planned this study to experimentally evaluate the effects of Rofecoxib, the selective cyclo-oxygenase-2 inhibitor, in postoperative intraperitoneal adhesions in an animal model.
- Intraobserver and interobserver reliability of videotaped laparoscopy evaluations for endometriosis and adhesionsPhilomeen T M Weijenborg
Department of Gynecology, Leiden University Medical Center, Leiden, The Netherlands
Fertil Steril 87:373-80. 2007..To determine the intra- and interobserver reliability of evaluations during videotaped laparoscopy, with real-time laparoscopy as the "gold standard."..
- Preoperative ultrasound to predict infraumbilical adhesions: a study of diagnostic accuracyFrank F Tu
Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
Am J Obstet Gynecol 192:74-9. 2005The purpose of this study was to determine the test characteristics of preoperative abdominal ultrasound in predicting infraumbilical adhesions in women.
- Long-term follow-up and cost analysis following surgery for small bowel obstruction caused by intra-abdominal adhesionsB Tingstedt
Department of Surgery, Lund University, Lund, Sweden
Br J Surg 94:743-8. 2007This study examined the natural course of patients following surgery for small bowel obstruction (SBO) caused by abdominal adhesions. In addition, a cost analysis was performed.
- Effectiveness of treatment to prevent adhesions after abdominal surgery: an experimental evaluation in ratsCem Kaan Parsak
Department of General Surgery, Cukurova University, School of Medicine, Adana, Turkey
Adv Ther 24:796-802. 2007..Ileal content was the leading cause of intraperitoneal adhesions in the first phase; in the second phase, in group 1, 2 mL ileal content and 5 mL povidone-iodine (10%) were used;..
- The effects of a combination of hyaluronic and amniotic membrane on the formation of peritendinous adhesions after flexor tendon surgery in chickensG Y Ozgenel
Department of Plastic and Reconstructive Surgery, Division of Hand Surgery, Uludag University Medical School, Bursa, Turkey
J Bone Joint Surg Br 86:301-7. 2004..the effects of the intra-operative application of a combination of hyaluronic acid and amniotic membrane on adhesions in the flexor tendons of a chicken model...
- Camptothecin-loaded films for the prevention of postsurgical adhesionsJ Cashman
ARC Pharmaceuticals Inc, University of British Columbia, 102 2386 East Mall, Vancouver BC, Canada
Inflamm Res 53:355-62. 2004..The purpose of this work was to investigate the local application of camptothecin (CPT), a drug with anti-inflammatory, antiproliferative and antiangiogenic properties, as an inhibitor of surgical adhesion formation in rats...
- Expression of connective tissue growth factor in intra-abdominal adhesionsKlaus Thaler
Department of Colorectal Surgery, Cleveland Clinic Florida, 2950 Cleveland Clinic Boulevard, Weston, FL 33331, USA
Dis Colon Rectum 45:1510-9. 2002..The aim of our study was to determine the expression pattern of connective tissue growth factor in postoperative intra-abdominal adhesions.
- Mast cells facilitate local VEGF release as an early event in the pathogenesis of postoperative peritoneal adhesionsRonan A Cahill
Department of Academic Surgery, Cork University Hospital, Ireland
Surgery 140:108-12. 2006..Peritoneal mast cells are likely to initiate this process, whereas vascular permeability/endothelial growth factor (VEGF) may facilitate the degree to which subsequent adhesion formation occurs...
- Can arthrocentesis release intracapsular adhesions? Arthroscopic findings before and after irrigation under sufficient hydraulic pressureShinya Yura
Oral and Maxillofacial Surgery, Tonami General Hospital, 1 6 Shintomi cho, Tonami City, Toyama ken 939 1395, Japan
J Oral Maxillofac Surg 61:1253-6. 2003To investigate the effect of release of intra-articular adhesions of arthrocentesis, we examined patients with closed lock of the temporomandibular joint by arthroscopy before and after irrigation.
- Role of laparoscopy in identifying the clinical significance and cause of adhesions and chronic pelvic pain: a retrospective review at the Kiel School of Gynecological EndoscopyLiselotte Mettler
Kiel School of Gynecological Endoscopy, Department of Obstetrics and Gynecology, University Hospitals Schleswig Holstein, Campus Kiel, Michaelisstrasse 16, Kiel 24105, Germany
JSLS 11:303-8. 2007We sought to define the role of laparoscopy in identifying the clinical significance, cause, and association between adhesions and chronic pelvic pain.
- Impact of adhesions in colorectal surgeryR Bhardwaj
Department of Surgery, Darent Valley Hospital, Kent, UK
Colorectal Dis 9:45-53. 2007The extent of the problem of adhesions is considerable and poses a significant burden on healthcare systems, the workload of surgeons and the lives of patients...
- Effectiveness of auto-cross-linked hyaluronic acid gel in the prevention of intrauterine adhesions after hysteroscopic adhesiolysis: a prospective, randomized, controlled studyGiuseppe Acunzo
Department of Obstetrics and Gynaecology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
Hum Reprod 18:1918-21. 2003A prospective, randomized, controlled study was performed to assess the efficacy of auto-cross-linked hyaluronic acid (ACP) gel in preventing the development of intrauterine adhesions following hysteroscopic adhesiolysis.
- Temporary ovarian suspension at laparoscopy for prevention of adhesionsMostafa I Abuzeid
Division of Reproductive Endocrinology, Hurley Medical Center, Two Hurley Plaza, Suite 101, Flint, MI 48503, USA
J Am Assoc Gynecol Laparosc 9:98-102. 2002..In four patients (80%), we found no evidence of recurrent adhesions. The remaining 20% had minimal adhesions...
- The incidence and morbidity of adhesions after treatment of neonates with gastroschisis and omphalocele: a 30-year reviewFloortje C van Eijck
Department of General Surgery, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
J Pediatr Surg 43:479-83. 2008..Knowledge of its incidence and potential risk factors in a well-documented group with strict follow-up is needed to guide preventive measures...
- Ovarian endometrioma: postoperative adhesions following bipolar coagulation and sutureM Pellicano
Department of Obstetrics and Gynecology, University of Naples Federico II, Naples, Italy
Fertil Steril 89:796-9. 2008To compare bipolar coagulation and suturing of the ovary in terms of postoperative ovarian adhesions after laparoscopic ovarian cystectomy for endometriosis.
- The effect of resveratrol on surgery-induced peritoneal adhesions in an experimental modelGokhan Sogutlu
General Surgery Department, Inonu University Medical School, Malatya, Turkey
Cell Biochem Funct 25:217-20. 2007..001, respectively). Introduction of resveratrol into the peritoneal cavity at the time of surgery reduced adhesion formation effectively in this model. Resveratrol probably acts through reduction of lipid peroxidation products...
- Endometrial thickness measured by ultrasound scan in women with uterine outlet obstruction due to intrauterine or upper cervical adhesionsSin Ting Lo
Department of Obstetrics and Gynaecology, Queen Elizabeth II Research Institute for Mothers and Infants, University of Sydney, NSW 2006 Australia
Hum Reprod 23:306-9. 2008A subgroup of women with Asherman's syndrome has adhesions of limited extent completely blocking the lower uterine cavity or upper cervix, whereas the upper endometrium remains normal. Haematometra are rarely found in these women...
- Reduction of postoperative perineural adhesions by Hyaloglide gel: an experimental study in the rat sciatic nervePhong Dam-Hieu
Experimental Neurosurgery Laboratory, Centre Hospitalier Universitaire de Bicetre, Faculte de Medecine Paris Sud, Le Kremlin Bicetre, France
Neurosurgery 56:425-33; discussion 425-33. 2005..To assess the effects of Hyaloglide gel (or auto-cross-linked polysaccharide [ACP] gel; Fidia Advanced Biopolymers, Abano Terme, Italy), a hyaluronan-derivative polymer, on peripheral nerve scarring and nerve regeneration...
- Effect of oral D-penicillamine vs. colchicine on experimentally induced peritoneal adhesions in ratsSaman Nikeghbalian
Shiraz Organ Transplantation Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Fertil Steril 88:1187-9. 2007..To evaluate the effects of d-penicillamine on prevention or reduction of adhesion band formation and to compare its effects with those of colchicine in an animal model...
- The effect of immunosuppression on peritoneal adhesions formation after small bowel transplantation in ratsNir Wasserberg
Department of Surgery, University of Miami School of Medicine, Miami, Florida, USA
J Surg Res 141:294-8. 2007..The purpose of the study was to investigate the influence of immunosuppression on peritoneal adhesion formation after intestinal transplantation in rats...
- The role of laparoscopic adhesiolysis in the treatment of patients with chronic abdominal pain or recurrent bowel obstructionVafa Shayani
Department of Surgery, Loyola University Medical Center, Maywood, IL 60153, USA
JSLS 6:111-4. 2002..Laparoscopic adhesiolysis may provide relief of symptoms in patients with prior abdominal surgery with chronic abdominal pain or recurrent bowel obstruction...
- Polymers in the prevention of peritoneal adhesionsYoon Yeo
School of Pharmacy and Pharmaceutical Sciences, Weldon School of Biomedical Engineering, Purdue University, West Lafayelte IN, USA
Eur J Pharm Biopharm 68:57-66. 2008Peritoneal adhesions are serious complications of surgery, and can result in pain, infertility, and potentially lethal bowel obstruction...
- Prevention of postoperative abdominal adhesions by a novel, glycerol/sodium hyaluronate/carboxymethylcellulose-based bioresorbable membrane: a prospective, randomized, evaluator-blinded multicenter studyZane Cohen
Department of Surgery, Mount Sinai Hospital, University of Toronto, Toronto, Canada
Dis Colon Rectum 48:1130-9. 2005Postoperative abdominal adhesions are associated with significant morbidity and mortality, placing a substantial burden on healthcare systems worldwide...
- Micronized purified flavonoid fraction may prevent formation of intraperitoneal adhesions in ratsHatice Gulsen Yilmaz
Department of General Surgery, Faculty of Medicine, University of Dicle, Diyarbakir, Turkey
Fertil Steril 84:1083-8. 2005To evaluate the efficacy of an anti-inflammatory and capillary regulator drug, micronized purified flavonoid fraction (MPFF), in the prevention of postoperative formation of adhesions.
- Crosslinked hyaluronan hydrogels containing mitomycin C reduce postoperative abdominal adhesionsYanchun Liu
Department of Medicinal Chemistry, The University of Utah, 419 Wakara Way, Salt Lake City, UT 84108, USA
Fertil Steril 83:1275-83. 2005To evaluate the efficacy of crosslinked hyaluronan (HA) hydrogels that contained covalently-bound mitomycin C (MMC) in reducing postoperative adhesions in a rat uterine horn model.
- Laser-Activated Collagen Adhesives for HerniorrhaphyBarbara Soltz; Fiscal Year: 2006..In fact, adhesions represent a significant source of morbidity and mortality and are a common cause of small bowel obstruction in ..
- Pathogen-host Interactions that Remodel the CytoskeletonTina Izard; Fiscal Year: 2010..actin cytoskeleton by binding to other key partners such as talin, which binds to integrin receptors in focal adhesions, or to a- actinin, which plays key roles in adherens junctions...
- Nuclear-Cytoplasmic Shuttling of Foxc2 via 14-3-3 Determines Proximal Tubule CellDIANA LYNNE GOLDEN; Fiscal Year: 2012..seen following ischemic tubular injury promotes [unreadable]-actinin stabilization and/or localization to focal adhesions, where it is critical for FA turnover and cell morphogenesis/migration...
- Growth Hormone Regulation of SH2B1Christin Carter-Su; Fiscal Year: 2013..g., focal adhesions, lamellipodia, cytoplasm, nucleus)...
- Genetic Analysis of FAK ActivityDavid D Schlaepfer; Fiscal Year: 2012..Signals generated by integrins at cell attachment sites termed focal adhesions are mediated by the recruitment of cytoskeletal and signaling proteins in a manner that remain under ..
- Regulation of Fibronectin Matrix Assembly by uPARPAULA J MC KEOWN-LONGO; Fiscal Year: 2012..whether uPAR-mediated EGFR transactivation reroutes the trafficking of EGFR from lysosomes and into focal adhesions where it forms complexes with the 1521 integrin...
- Ibuprofen and enteric neural crest precursor migrationELLEN MERRICK; Fiscal Year: 2013..These investigations will allow for in depth analysis of ENCC actin protrusions and the dynamics of focal adhesions. In addition, ENCCs from transgenic animals with null mutations in Cox1 and Cox2, enzymes inhibited by ibuprofen,..
- The Role of Leptin in Liver FibrogenesisFrank A Anania; Fiscal Year: 2012..of hepatic fibrosis by inhibiting activation of focal adhesion kinase (FAK), preventing formation of focal adhesions (FA) which results in the suppression of key fibrogenic properties of the activated HSC...
- Structure and function of stress fibers and cell adhesion sitesMary C Beckerle; Fiscal Year: 2013..of catastrophic stress fiber breaks and restores the capacity of stress fibers to transmit force via the focal adhesions to the underlying substrate...
- Role of the Tail Domain in Vinculin FunctionSharon L Campbell; Fiscal Year: 2010..applicant): This proposal is focused on vinculin, a cytoskeletal protein that is a prominent component of focal adhesions and adherens junctions...
- Multiple Molecular Mechanisms for Adiponectin Therapy in Hepatic FibrogenesisFrank A Anania; Fiscal Year: 2013..of hepatic fibrosis by inhibiting activation of focal adhesion kinase (FAK), preventing formation of focal adhesions (FAs), which results in the suppression of key fibrogenic properties of the activated HSC...
- Role of Focal Adhesion Kinase (FAK) in Nephrosis and NephritisShuta Ishibe; Fiscal Year: 2013..contacts between the glomerular basement membrane and the extracellular matrix, which is comprised of focal adhesions and integrins...
- Novel anti-toxin compounds against Yersinia infectionsMaurizio Pellecchia; Fiscal Year: 2010..type III sectretion system, YopH is a highly active bacterial PTPase that is results in disruption of focal adhesions, and inhibition of integrin-mediated bacterial phagocytosis, both of which are highly dependent on tyrosine ..
- Role of Nox4 in VSMC MigrationMAZEN KHALIL KHALIL; Fiscal Year: 2011..This results in actin polymerization and formation of focal adhesions (FA). The cell uses the FA as a strut against which it contracts and moves...
- Signaling Connections Controlling Cell Motility and InvasionDavid D Schlaepfer; Fiscal Year: 2013..is a highly regulated process that involves the formation and turnover of cell-matrix contact sites termed focal adhesions, sites of matrix-integrin attachment, tension generation, and cell survival signals...
- Smooth muscle adhesion and plasticity in coronary and outflow tract developmentJoan M Taylor; Fiscal Year: 2013..We also made the interesting and potentially important discovery that leupaxin shuttles between focal adhesions and the nucleus and that this process was regulated by FAK signaling...
- Mechanism and role of DLC-1 tumor suppressor loss in lung cancerChanning J Der; Fiscal Year: 2012..DLC-1 is associated with focal adhesions (FAs) and this association is critical for DLC-1 tumor suppression but surprisingly, not for Rho GTPase ..
- Stress: Potential Impact on an Animal Model of EndometriosisCaroline B Appleyard; Fiscal Year: 2012..This condition is characterized by peritoneal inflammation, fibrosis, adhesions and ovarian cysts, which result in chronic pelvic pain, pain during intercourse (dyspareunia), painful periods (..
- Endoplasmic reticulum structure and dynamics in breast cancer cell metastasis andJASON EDWARD LEE; Fiscal Year: 2013..recent studies have reported that integrin-[unreadable]3 and protein phosphatase 1B (PTP1B) trafficking to focal adhesions was dependent on ER tubule extension along microtubules...
- ABNORMAL BIGH3 AGGREGATIONS IN CORNEAL DYSTROPHIESAndrew J W Huang; Fiscal Year: 2011..These dystrophies are found to have abnormal stromal deposits and related poor epithelial adhesions with resultant painful corneal erosions. Corneal transplantation is often needed to restore corneal clarity...
- Spatiotemporal Regulation of Membrane Raft Trafficking in Virus Activated CellsTione Buranda; Fiscal Year: 2012..that the initial binding of SNV to DAF is followed by Rac1 stimulated actin remodeling, disassembly of focal adhesions, and leads to loss of cell-cell contact and cell-substrate adhesion...
- OUTER MEMBRANE PROTEINS OF PATHOGENIC LEPTOSPIRA SPECIESDavid A Haake; Fiscal Year: 2013..of these aims, we will examine the molecular mechanisms by which OMPs are regulated, identify additional OMP adhesions and examine their roles in pathogenesis and immunity, and develop E...
- Identification of Mechanically Sensitive Proteins in Early DevelopmentDouglas W DeSimone; Fiscal Year: 2013..will also be developed that will enable simultaneous application of force to both cadherin and integrin adhesions in order to mimic tissue-level stresses in single cells...
- The Role of HEF1 in Ovarian Cancer Development, Progression, and MetastasisDenise C Connolly; Fiscal Year: 2013HEF1/NEDD9/Cas-L (HEF1) is a molecular scaffolding protein that mediates cellular signaling from focal adhesions during interphase and at centrosomes during mitosis...
- Mechanically Stressed VSMC: A Role for Slingshot Phosphatase in InflammationAlejandra San Martin; Fiscal Year: 2013..One main source of ROS in the vasculature is Nox4, which is found in focal adhesions (FAs), the sites of engagement of the cell to the extracellular substrate...
- Quantitative Analysis of Chemotactic Motility Cycle of Ameboid CellsJUAN CARLOS LASHERAS; Fiscal Year: 2013..of actin-directed motors, F-actin regulation, actin crosslinking, motor protein-mediated contractility, and cell adhesions. However, precise knowledge of the biophysical coordination of these processes has been limited by the lack of ..
- Microtubule-associated RacAnna Birukova; Fiscal Year: 2013..In contrast, effects of barrier-protective agents on crosstalk between MT, cell adhesions, and actin cytoskeleton are not clear, nor the role of MT changes in Rac regulation is described...
- Mechanisms of glomerular disesase progressionJeffrey R Schelling; Fiscal Year: 2012..unreadable]8-dependent cell adhesion - the first demonstration of any [unreadable]8 ligand supporting stable adhesions. We have shown that [unreadable]8 interacts with Rho GDI...
- Macrophage Infiltration of Renal Tissue via beta-3 Integrins and AgrinScott D Blystone; Fiscal Year: 2013..We will characterize the production of macrophage podosomal adhesions and pseudopods that are required for migration into three-dimensional tissues by TIRF microscopy of living ..
- Molecular Function of Palladin's Ig Domains in Cell Adhesion and MotilityCarol A Otey; Fiscal Year: 2010DESCRIPTION (provided by applicant): Both cell-cell and cell-matrix adhesions require the participation of the actin cytoskeleton...
- Regulation of Axon Guidance by Second MessengersTimothy M Gomez; Fiscal Year: 2013..is focused on understanding how axon guidance cues regulate axon outgrowth by modulating integrin-dependent adhesions. As a number of cognitive disorders result from improper axon pathfinding, understanding the molecular basis for ..
- NoxR1, a regulator of Nox4-dependent cytoskeletal remodeling in vascular cellsKathy K Griendling; Fiscal Year: 2010..that NoxR1 overexpression in VSMCs causes a significant increase in NADPH oxidase activity, an increase in focal adhesions, and an increase stress fiber formation, while knockdown of NoxR1 induces a profound alteration of the ..
- Anti-angiogenic activity of neurokinin BSoumen Paul; Fiscal Year: 2010..of focal adhesion kinase, paxillin, p130Cas, spatial and temporal association of these molecules to form focal adhesions, and activation of Rho family of GTPases Rac1 and CDC42...
- Directing Stem Cell Differentiation on Biologically Inspired Micropatterned SurfaAnita Shukla; Fiscal Year: 2012..It is hypothesized that hMSCs that are restricted to making focal adhesions directly mimicking the adhesions of fully differentiated cells will preferentially differentiate to these ..
- Deleted in liver cancer 1 (DLC1) in liver development and diseaseYi Ping Shih; Fiscal Year: 2013..DLC1 regulates cell migration through modulation of the actin cytoskeleton and focal adhesions. Multiple studies have demonstrated that the RhoGAP domain is necessary for the tumor suppressive function of ..
- Role of Surface Roughness in Regulating Tumor Cell BehaviorSarah C Glover; Fiscal Year: 2012..less and more tumorigenic cells cultured on a "peak-like" matrix actually had higher Rho activity and more focal adhesions as revealed by talin staining...
- Vascular Oxidases in MigrationKathy K Griendling; Fiscal Year: 2013..accompanies lamellipodial protrusion, while the production of H2O2 by integrin-mediated Nox4 activation in focal adhesions regulates focal adhesion turnover and stabilizes actin filaments via oxidation...
- The effects of stress on the pathophysiology of endometriosisMARIELLY CUEVAS; Fiscal Year: 2010..This condition is characterized by peritoneal inflammation, fibrosis, adhesions and ovarian cysts, which result in chronic pelvic pain, pain during intercourse (dyspareunia), painful periods (..
- Integrin Targeted Therapy for the Treatment of Ovarian CancerFRANK CALZONE; Fiscal Year: 2013..and polyethylene oxide (PEO) gel approved for human use in Europe and Australia for prevention of post-surgical adhesions. This approach combines the benefits of high-concentration local peritoneal treatment as well as sustained drug ..
- Cell Adhesion and the Regulation of Rho GTPasesKeith Burridge; Fiscal Year: 2013..This grant is aimed at understanding how signals from cell-matrix adhesions regulate members of the Rho family of GTPases, which are themselves key regulators of the cytoskeleton and many ..
- The role of CTGF in bone cell development and functionSteven N Popoff; Fiscal Year: 2012..that osteoblasts attach to CTGF via the av[unreadable]5 integrin, resulting in the formation of focal adhesions, cytoskeletal reorganization and the activation of FAK and Erk...
- STRUCTURAL DYNAMICS OF VINCULIN IN ADHESION JUNCTIONSTina Izard; Fiscal Year: 2012DESCRIPTION (provided by applicant): The formation of cell-matrix (focal adhesions) and cell-cell (adherens junctions) adhesion complexes links signals at the cell surface to the actin cytoskeleton, and these direct cell migration, cell ..
- Protein kinase B (Akt)-mediated pathway regulating endothelial-barrier functionSOMANATH P RAMMOHAN SHENOY; Fiscal Year: 2013..results, we postulate that the events leading to VP, such as expression and/or dynamics of integrins, focal adhesions, cytoskeletal proteins and cortical actin, are dependent on the ability of Akt to differentially modulate 2-Pix-..
- Novel role of AQP2 in cell migration and kidney tubular injury and repairHUA A LU; Fiscal Year: 2013..interacts with integrin [unreadable]1, modulates the trafficking and turnover of integrin [unreadable]1 at focal adhesions (FAs)...
- Image-Guided Surgery of Endocrine Glands and Their Tumors using Near-Infrared FluJohn V Frangioni; Fiscal Year: 2013..tissues, such as the thyroid gland and adrenal gland, can often be difficult to locate during surgery due to adhesions and overlying fascia...
- Characterization of a novel protein required for glomerular podocyte functionLORI L O'BRIEN; Fiscal Year: 2012..As active calpains promote detachment of cellular adhesions, the current hypothesis is that PGAF inhibits calpain activity in podocytes to prevent foot process detachment...
- Actin protrustions, oocytes: Myosin VIIA and the actin cytoskeletonJENNIFER LEIGH SALLEE; Fiscal Year: 2012..microscopy, focusing on irregularities in actin rich structures such as ring canals, microvilli, and cell-cell adhesions. Together these aims will provide insight into how protein complexes are contributing to ck/Myosin VIIA function ..
- Peptide therapeutics for inhibiting abdominal adhesionsCYNTHIA ELLEN LANDER; Fiscal Year: 2012DESCRIPTION (provided by applicant): Disease definition: Adhesions, fibrous scars abnormally conjoining adjacent tissues, are primarily caused by surgical procedures...
- Novel Mechanisms of NSAID-induced GI ToxicityJames D Lillich; Fiscal Year: 2012..determine if NSAIDs impair de-adhesion of cell contacts by measuring the number and distribution of cellular adhesions as well as the expression and rate of turnover of specific adhesion components...
- Phosphoinsitide signaling in Breast Epithelial Morphogenesis and MetastasisKun Ling; Fiscal Year: 2013..interactions generally inhibit cell migration and cancer metastasis, whereas integrin signals at cell-matrix adhesions are required for migration and metastasis...
- Actions of the Sodium-Hydrogen Exchanger Subtype, NHE1Diane L Barber; Fiscal Year: 2012..In Aim 3 we determine the role of NHE1-regulated focal adhesion proteins in remodeling cell-substrate adhesions and in directed migration of fibroblasts...
- The Role of Osteoactivin in Osteoblast Development and FunctionFayez F Safadi; Fiscal Year: 2013..that osteoblasts attach to OA via the [unreadable]v[unreadable]1 integrin, resulting in the formation of focal adhesions, cytoskeletal reorganization and the activation of FAK...
- Mutations in Smooth Muscle Contractile Proteins: Pathways to Vascular DiseasesDianna M Milewicz; Fiscal Year: 2013..of function" in muscular arteries, specifically increased SMC proliferation as a consequence of altered focal adhesions and activation of PDGFR-Beta receptors in response to abnormal cellular force generation...
- Cytoskeletal regulation of T cell-APC interactionsAnna Huttenlocher; Fiscal Year: 2012..contact sites, known as the immune synapse, share many structural components with integrin-mediated focal adhesions, we have demonstrated that the adhesive mechanisms that regulate T cell-APC contact site dynamics are distinct...
- Biophysical Regulation of Breast DifferentiationPatricia J Keely; Fiscal Year: 2013..Our hypothesis is that locally dense ECM enhances the formation of matrix adhesions that result in activation of signaling pathways linked to FAK, and that FAK is a central mediator by which ..
- HEF1 Coordination of Cell Cycle, Migration, and Invasion in CancerErica A Golemis; Fiscal Year: 2013..HEF1 acts to assemble signaling complexes at focal adhesions in interphase cells, at the centrosome in pre-mitotic cells, and at the cilium in cells emerging from quiescence...
- The role of Vimentin in cell adhesion and lung cancer metastasisLAUREN SMITH HAVEL; Fiscal Year: 2013..Vimentin is a dynamic protein whose assembly and disassembly is critical for the formation of new focal adhesions that regulate cell adhesion...
- Role of Irf6 in palatal epitheliumYoussef A Kousa; Fiscal Year: 2013..Third, we know that changes in Irf6 dose lead to clefting and oral adhesions in the mouse...
- Enhanced Tendon Healing through Growth Factor and Cell TherapiesStavros Thomopoulos; Fiscal Year: 2013..Poor clinical outcomes typically result from early repair-site failure and the formation of adhesions between the tendon and its surrounding synovial sheath...
- Zosteric Acid Integrated Thermo-reversible Gels for Preventing Surgical AdhesionsBi min Newby; Fiscal Year: 2012DESCRIPTION (provided by applicant): The development of adhesions following surgery represents a significant, costly morbidity typically expressed as pain and infertility in the patient...
- Device for Surgical Adhesion PreventionREKHA BANSAL; Fiscal Year: 2010..S. where the patient is at risk for the complications from surgical adhesions. After surgery, fibrous adhesions form in the peritoneum, central nervous system, pericardium, pleura and ..
- MULTIDISCIPLINARY STRUCTURES AT VASCULAR CELL SURFACESTimothy A Springer; Fiscal Year: 2013..Project 6 (Eck) examines signaling at focal adhesions and explores activation of the tyrosine kinase of FAK by phosphatidylinositol phosphates through use of ..
- Obstruction-initiated mechanotranscription in colonic smooth muscle cellsXuan Zheng Shi; Fiscal Year: 2012..Numerous pathological conditions, including adhesions, carcinomas, and Hirschsprung's disease, result in obstruction in the gut...
- Structure and function of the integrin-linked kinase-PINCH-parvin complexDavid A Calderwood; Fiscal Year: 2012..networks, and in mammalian systems IPP complex formation precedes and is required for its correct targeting to adhesions. There are currently significant deficiencies in our understanding of how the IPP complex forms, how it ..
- Aqueous humor dynamics studies in vivo and in vitroPAUL LEON KAUFMAN; Fiscal Year: 2010..be enhanced by ILK, PI3K and Src kinase inhibitors, which have been shown to alter the cytoskeleton and cellular adhesions of trabecular meshwork (TM) cells in culture...
- Endogenous Hormones and Risk of EndometriosisStacey Missmer; Fiscal Year: 2009..The consequence is the development of adhesions, scarring, and painful inflammation...
- Xenobiotics and Breast Epithelial Cell-ECM SignalingRaymond Novak; Fiscal Year: 2005..Cells are linked to the ECM via integrin-containing focal adhesions. Other types of structures that link cells to each other or to the ECM include adherens junctions and desmosomes...
- G Proteins and Endothelial Barrier RegulationTatyana Voyno Yasenetskaya; Fiscal Year: 2004..that G-alpha13 protein interacts with the actin-binding protein, radixin, implicated in the assembly of focal adhesions and actin filaments...
- A new absorbable mesh for hernia repairDavid Martin; Fiscal Year: 2007..The absorbability of the mesh would reduce late term fistula and risk of infection and possibly tissue adhesions. Greater flexibility of the fiber will reduce mesh stiffness and eventual absorption will reduce the stiffness ..
- Treatment of Endometriosis-Associated Pelvic PainDavid Guzick; Fiscal Year: 2007..Surgical treatment of endometriosis with laparoscopic excision of implants and lysis of adhesions is often successful in reducing pain in the short term...
- MOLECULAR MECHANISMS OF NEURONAL CELL MIGRATIONRichard Cameron; Fiscal Year: 2000..At present, data indicate that members of several distinct classes of cell adhesions proteins are likely to mediate many of the cell sorting events that characterize neuronal cell migration...
- THREE DIMENSIONAL STRUCTURE OF ALPHA ACTININKenneth Taylor; Fiscal Year: 2000..In tissue cultured cells, alpha-actinin is located in focal adhesions and stress fibers, structural analogs of adhesion plaques and dense bodies...
- A Novel Approach to Prevent Periduaral FibrosisJames Pachence; Fiscal Year: 2001..Although inflammation and production of extracellular matrix components is necessary for normal wound healing, adhesions may also occur which can lead to significant clinical complications...
- Sutureless Resorbable Anti-Adhesion FilmsMICHAEL J DANILICH; Fiscal Year: 2010Postoperative adhesions are an expected outcome with nearly every abdominal operation. Complications caused by adhesions include small bowel obstruction, female infertility, chronic debilitating pain, and difficulty in future operations...