adhesions

Summary

Summary: Pathological processes consisting of the union of the opposing surfaces of a wound.

Top Publications

  1. ncbi Molecular characterization of postoperative adhesions: the adhesion phenotype
    Ghassan M Saed
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA
    J Am Assoc Gynecol Laparosc 11:307-14. 2004
  2. ncbi Reduction of postoperative adhesions with an auto-crosslinked hyaluronan gel in gynaecological laparoscopic surgery: a blinded, controlled, randomized, multicentre study
    V Mais
    Division of Gynecology, Obstetrics and Pathophysiology of Human Reproduction, Department of Surgery, Maternal Fetal Medicine and Imaging, University of Cagliari, Italy
    Hum Reprod 21:1248-54. 2006
  3. ncbi Prevention of peritoneal adhesions by intraperitoneal administration of vitamin E: an experimental study in rats
    Fernando de la Portilla
    Coloproctology Unit, Department of General Surgery, Hospital Juan Ramon Jimenez, Huelva, Spain
    Dis Colon Rectum 47:2157-61. 2004
  4. ncbi Laparoscopy for adhesions
    Petachia Reissman
    Department of Surgery, Shaare Zedek Medical Center, Jerusalem, Israel
    Semin Laparosc Surg 10:185-90. 2003
  5. ncbi Prevention of adhesions by bioresorbable tissue barrier following laparoscopic intraabdominal mesh insertion
    M Mahir Ozmen
    Department of Surgery and Pathology, Ankara Numune Teaching and Research Hospital, Turkey
    Surg Laparosc Endosc Percutan Tech 12:342-6. 2002
  6. ncbi Fewer adhesions induced by laparoscopic surgery?
    C N Gutt
    Department of General, Visceral and Trauma Surgery, Ruprecht Karls University, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
    Surg Endosc 18:898-906. 2004
  7. pmc In situ cross-linkable hyaluronan hydrogels containing polymeric nanoparticles for preventing postsurgical adhesions
    Yoon Yeo
    Department of Chemical Engineering and Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA
    Ann Surg 245:819-24. 2007
  8. pmc Prevention of postsurgery-induced abdominal adhesions by electrospun bioabsorbable nanofibrous poly(lactide-co-glycolide)-based membranes
    Xinhua Zong
    Department of Chemistry, Stony Brook University, Stony Brook, New York 11794 3400, USA
    Ann Surg 240:910-5. 2004
  9. ncbi The effects of anti-adhesion materials in preventing postoperative adhesion in abdominal cavity (anti-adhesion materials for postoperative adhesions)
    Mustafa Sahin
    Department of General Surgery, Selcuk University Meram Medical Faculty, Konya, Turkey
    Inflammation 30:244-9. 2007
  10. ncbi Comparative effectiveness of several agents for preventing postoperative adhesions
    Jehat Kutlay
    2nd General Surgery Department, SSK Ankara Teaching Hospital, Ankara 06090, Turkey
    World J Surg 28:662-5. 2004

Detail Information

Publications229 found, 100 shown here

  1. ncbi Molecular characterization of postoperative adhesions: the adhesion phenotype
    Ghassan M Saed
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA
    J Am Assoc Gynecol Laparosc 11:307-14. 2004
    ..To date, approaches to limit adhesions primarily have involved barriers to separate tissue during reepithelization...
  2. ncbi Reduction of postoperative adhesions with an auto-crosslinked hyaluronan gel in gynaecological laparoscopic surgery: a blinded, controlled, randomized, multicentre study
    V Mais
    Division of Gynecology, Obstetrics and Pathophysiology of Human Reproduction, Department of Surgery, Maternal Fetal Medicine and Imaging, University of Cagliari, Italy
    Hum Reprod 21:1248-54. 2006
    Following myomectomy, postoperative adhesions occur in many patients with adverse effects on fertility...
  3. ncbi Prevention of peritoneal adhesions by intraperitoneal administration of vitamin E: an experimental study in rats
    Fernando de la Portilla
    Coloproctology Unit, Department of General Surgery, Hospital Juan Ramon Jimenez, Huelva, Spain
    Dis Colon Rectum 47:2157-61. 2004
    Previous studies have shown dietary supplements of vitamin E to reduce the incidence of postoperative peritoneal adhesions. The objective of this study was to show the effect of intramuscular or intraperitoneal administration of vitamin ..
  4. ncbi Laparoscopy for adhesions
    Petachia Reissman
    Department of Surgery, Shaare Zedek Medical Center, Jerusalem, Israel
    Semin Laparosc Surg 10:185-90. 2003
    Intestinal and abdominal adhesions may be responsible for a variety of clinical conditions, including chronic recurrent small-bowel obstruction, acute small-bowel obstruction, closed-loop bowel obstruction and, debatably, abdominal or ..
  5. ncbi Prevention of adhesions by bioresorbable tissue barrier following laparoscopic intraabdominal mesh insertion
    M Mahir Ozmen
    Department of Surgery and Pathology, Ankara Numune Teaching and Research Hospital, Turkey
    Surg Laparosc Endosc Percutan Tech 12:342-6. 2002
    Intraabdominal adhesions represent a significant problem because of the morbidity associated with adhesive disease, including small bowel obstruction, difficulties in reoperative surgery, and possibly chronic pain...
  6. ncbi Fewer adhesions induced by laparoscopic surgery?
    C N Gutt
    Department of General, Visceral and Trauma Surgery, Ruprecht Karls University, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
    Surg Endosc 18:898-906. 2004
    ..Laparoscopic surgery has potential theoretical advantages over open surgery in reducing the rate of adhesion formation, but very few comparative studies are available to prove this...
  7. pmc In situ cross-linkable hyaluronan hydrogels containing polymeric nanoparticles for preventing postsurgical adhesions
    Yoon Yeo
    Department of Chemical Engineering and Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA
    Ann Surg 245:819-24. 2007
    ..barrier method and drug delivery system ("hybrid system") for preventing postoperative peritoneal adhesions, which could combine the biocompatibility and ease of application of in situ cross-linkable hydrogels with the ..
  8. pmc Prevention of postsurgery-induced abdominal adhesions by electrospun bioabsorbable nanofibrous poly(lactide-co-glycolide)-based membranes
    Xinhua Zong
    Department of Chemistry, Stony Brook University, Stony Brook, New York 11794 3400, USA
    Ann Surg 240:910-5. 2004
    The objective of this study was to evaluate the efficacy of nonwoven bioabsorbable nanofibrous membranes of poly(lactideco-glycolide) for prevention of postsurgery-induced abdominal adhesions.
  9. ncbi The effects of anti-adhesion materials in preventing postoperative adhesion in abdominal cavity (anti-adhesion materials for postoperative adhesions)
    Mustafa Sahin
    Department of General Surgery, Selcuk University Meram Medical Faculty, Konya, Turkey
    Inflammation 30:244-9. 2007
    The purpose of this study was to compare the effects of anti-adhesion materials in postoperative adhesions.
  10. ncbi Comparative effectiveness of several agents for preventing postoperative adhesions
    Jehat Kutlay
    2nd General Surgery Department, SSK Ankara Teaching Hospital, Ankara 06090, Turkey
    World J Surg 28:662-5. 2004
    Postoperative adhesions (PAs) are usually clinically asymptomatic...
  11. ncbi Intrauterine adhesions after conservative and surgical management of spontaneous abortion
    Wing Hung Tam
    Department of Obstetrics and Gynaecology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    J Am Assoc Gynecol Laparosc 9:182-5. 2002
    To determine the frequency of intrauterine adhesions (IUA) after conservative management, medical evacuation, and surgical evacuation for spontaneous abortion.
  12. ncbi Seprafilm (modified hyaluronic acid and carboxymethylcellulose) acts as a physical barrier
    L April Gago
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Fertil Steril 80:612-6. 2003
    ..To characterize the molecular changes that occur in normal fibroblasts, adhesion fibroblasts, and mesothelial cells as a result of exposure to modified hyaluronic acid and carboxymethylcellulose (Seprafilm)...
  13. ncbi In situ cross-linkable hyaluronic acid hydrogels prevent post-operative abdominal adhesions in a rabbit model
    Yoon Yeo
    Department of Chemical Engineering, 77 Massachusetts Avenue, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Biomaterials 27:4698-705. 2006
    ..the efficacy of an in situ cross-linked hyaluronic acid hydrogel (HAX) in preventing post-surgical peritoneal adhesions, using a rabbit sidewall defect-cecum abrasion model...
  14. ncbi Prevention of abdominal adhesions--present state and what's beyond the horizon?
    B Tingstedt
    Department of Surgery, Lund University, Lund, Sweden
    Eur Surg Res 39:259-68. 2007
    Intra-abdominal adhesions are normally found after most surgical procedures...
  15. ncbi Modulation of the expression of tissue plasminogen activator and its inhibitor by hypoxia in human peritoneal and adhesion fibroblasts
    Ghassan M Saed
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, and the C S Mott Center for Human Growth and Development, Wayne State University, Detroit, Michigan 48201, USA
    Fertil Steril 79:164-8. 2003
    ..To determine whether normal peritoneal and adhesion fibroblasts express tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI-I) and whether their expression is regulated by oxygen...
  16. ncbi RNA interference targeting hypoxia inducible factor 1alpha reduces post-operative adhesions in rats
    Tatiana Segura
    Ecole Polytechnique Federale de Lausanne EPFL, Institute of Bioengineering and Institute of Chemical Sciences and Engineering, Lausanne, Switzerland
    J Surg Res 141:162-70. 2007
    ..To investigate the use of RNA interference mediated gene down-regulation targeting hypoxia inducible factor 1alpha (HIF-1alpha) and plasminogen activator inhibitor 1 (PAI-1) in an effort to prevent abdominal adhesion formation...
  17. pmc Adhesions in a murine flexor tendon graft model: autograft versus allograft reconstruction
    Sys Hasslund
    The Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA
    J Orthop Res 26:824-33. 2008
    Reconstruction of flexor tendons often results in adhesions that compromise joint flexion. Little is known about the factors involved in the formation of flexor tendon graft adhesions...
  18. ncbi Consequences and complications of peritoneal adhesions
    H van Goor
    Department of Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Colorectal Dis 9:25-34. 2007
    ..b>Adhesions to the ventral abdominal wall are responsible for the majority of trocar injuries...
  19. ncbi Evaluation of hyaluronic acid sheet for the prevention of postlaminectomy adhesions
    Tsuyoshi Kato
    Department of Spinal and Orthopaedic Surgery, Tokyo Medical and Dental University, Graduate School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 5819, Japan
    Spine J 5:479-88. 2005
    ..Hyaluronic acid (HA) solution and gel have been reported to be effective in preventing adhesions postlaminectomy; however, neither has been used clinically after spinal surgery.
  20. ncbi Adhesion-related readmissions following gynaecological laparoscopy or laparotomy in Scotland: an epidemiological study of 24 046 patients
    A M Lower
    Isis Fertility Centre, Colchester CO4 9YA, UK
    Hum Reprod 19:1877-85. 2004
    ..This study evaluated the epidemiology of adhesion-related readmissions following open and laparoscopic procedures...
  21. ncbi A randomized, controlled pilot study of the safety and efficacy of 4% icodextrin solution in the reduction of adhesions following laparoscopic gynaecological surgery
    G S diZerega
    University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Hum Reprod 17:1031-8. 2002
    Adhesion-related readmissions are frequent sequelae to gynaecological surgery. Attempts to prevent adhesions by separating healing peritoneal surfaces include site-specific barriers and hydroflotation by instilled solutions...
  22. ncbi Peritoneal adhesions: pathogenesis, assessment and effects
    M P Senthilkumar
    Department of Surgery, Dumfries and Galloway Royal Infirmary, Dumfries, UK
    Trop Gastroenterol 27:11-8. 2006
    As modem surgery has evolved, there has been an increase in iatrogenic peritoneal adhesions. Most surgeons manage adhesions and their related complications on a regular basis...
  23. ncbi Population-based study of the surgical workload and economic impact of bowel obstruction caused by postoperative adhesions
    J Kössi
    Department of Surgery, University of Turku, Turku, Finland
    Br J Surg 90:1441-4. 2003
    Intestinal obstruction is the most severe consequence of adhesion formation. This study examined the annual surgical workload and costs of intestinal obstruction caused by postoperative intra-abdominal adhesions.
  24. ncbi Clinical evaluation of a viscoelastic gel for reduction of adhesions following gynaecological surgery by laparoscopy in Europe
    P Lundorff
    Department of Obstetrics and Gynecology, Viborg Hospital, Viborg, Denmark
    Hum Reprod 20:514-20. 2005
    ..Commonly used adhesion prevention devices either cannot be applied or are difficult to use via laparoscopy. A viscoelastic gel was developed specifically for adhesion prophylaxis during minimally invasive surgery...
  25. ncbi Apoptosis and proliferation of human peritoneal fibroblasts in response to hypoxia
    Ghassan M Saed
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, and the C S Mott Center for Human Growth and Development, Wayne State University, Detroit, Michigan 48201, USA
    Fertil Steril 78:137-43. 2002
    To determine the effect of hypoxia on apoptosis and proliferation of fibroblasts cultured from normal peritoneum or adhesions.
  26. ncbi Reduction of postoperative adhesions by N,O-carboxymethylchitosan and spermine NONOate in rats
    Bulent Duran
    Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey
    Exp Anim 52:267-72. 2003
    Postsurgical adhesions can occur following virtually all types of surgery, resulting in serious clinical complications. Therefore, prevention of adhesions is an important goal of surgical practice...
  27. ncbi Adhesion formation after laparoscopic excision of endometriosis and lysis of adhesions
    Jason D Parker
    National Institutes of Health, Bethesda, MD, USA
    Fertil Steril 84:1457-61. 2005
    ..To evaluate adhesion reformation after laparoscopic excision of endometriosis and adhesiolysis in women with chronic pelvic pain...
  28. ncbi The prevalence of interstitial cystitis, endometriosis, adhesions, and vulvar pain in women with chronic pelvic pain
    Edward J Stanford
    Department of Urogynecology Obstetrics and Gynecology, St Mary s Good Samaritan Hospital, Centralia, Illinois 62801, USA
    J Minim Invasive Gynecol 12:43-9. 2005
    ..To estimate the prevalence of bladder-origin pain, intraperitoneal pathology, and vulvar pain in patients undergoing laparoscopy for chronic pelvic pain (CPP)...
  29. ncbi Use of a high-molecular-weight carboxymethylcellulose in a tissue protective solution for prevention of postoperative abdominal adhesions in ponies
    David J Murphy
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610, USA
    Am J Vet Res 63:1448-54. 2002
    To evaluate efficacy and safety of IP administration of high-molecular-weight carboxymethylcellulose (HMW CMC) for the prevention of postoperative intra-abdominal adhesions in ponies.
  30. doi Role of fibrin glue in the prevention of peritoneal adhesions in ventral hernia repair
    Juan Antonio Martín-Cartes
    Surgical Department, Laparoscopic Surgery Unit, Virgen del Rocio University Hospital, c Baños 76, 41002, Seville, Spain
    Surg Today 38:135-40. 2008
    ..The aim of this study was to investigate the effects of fibrin glue on the prevention of postoperative peritoneal adhesion to prosthetic materials used in ventral hernia repair...
  31. ncbi Expression of transforming growth factor-beta and extracellular matrix by human peritoneal mesothelial cells and by fibroblasts from normal peritoneum and adhesions: effect of Tisseel
    Ghassan M Saed
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University Detroit Medical Center, Hutzel Hospital, 4707 St Antoine Boulevard, Detroit, MI 48201, USA
    Wound Repair Regen 12:557-64. 2004
    We have previously shown that fibroblasts obtained from adhesions produce greater amounts of transforming growth factor-beta 1 (TGF-beta1) and extracellular matrix (ECM) molecules than normal fibroblasts isolated from normal peritoneum...
  32. ncbi Reduction of adhesions with composite AlloDerm/polypropylene mesh implants for abdominal wall reconstruction
    Charles E Butler
    Department of Plastic Surgery, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Plast Reconstr Surg 114:464-73. 2004
    ..includes the use of structural prosthetic materials, such as polypropylene mesh, that can induce dense abdominal adhesions to peritoneal structures. AlloDerm (LifeCell Corp., Branchburg, N.J...
  33. ncbi The effect of Seprafilm on adhesions in strabismus surgery-an experimental study
    Seyhan B Ozkan
    Department of Ophthalmology, Adnan Menderes University Medical School, Aydm, Turkey
    J AAPOS 8:46-9. 2004
    ..b>Adhesions occurring after strabismus surgery may affect surgical outcome...
  34. ncbi Peritoneal fluid concentrations of matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and transforming growth factor-beta in women with pelvic adhesions
    Ying C Cheong
    Department of Obstetrics and Gynaecology, St Mary s Hospital, Milton Road, Portsmouth, Hampshire, United Kingdom
    Fertil Steril 79:1168-75. 2003
    ..tissue inhibitor of metalloproteinase-1 (TIMP-1), and transforming growth factor-beta (TGF-beta) is influenced by the presence or absence of adhesions, and whether the concentration of these mediators vary throughout the menstrual cycle.
  35. ncbi Comparison of two laparoscopic treatments for experimentally induced abdominal adhesions in pony foals
    Jennifer L Lansdowne
    Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Canada
    Am J Vet Res 65:681-6. 2004
    To compare laparoscopic dissection with-laparoscopic dissection combined with abdominal instillation of ferric hyaluronate gel for the treatment of experimentally induced adhesions in pony foals.
  36. ncbi Bowel injury as a complication of laparoscopy
    M van der Voort
    Department of Surgery, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Br J Surg 91:1253-8. 2004
    ..Bowel injury is a rare but serious complication of laparoscopic surgery. This review examines the incidence, location, time of diagnosis, causative instruments, management and mortality of laparoscopy-induced bowel injury...
  37. ncbi Special techniques in pain management: lysis of adhesions
    Carlos O Viesca
    Texas Tech University Health Sciences Center, 3601 4th Street, Room 1C 282, Lubbock, TX 79430, USA
    Anesthesiol Clin North America 21:745-66, vi. 2003
    ..To enhance treatment outcome, an understanding of the pathophysiology of the underlying pain and the design of target-specific treatment modalities is important...
  38. ncbi Reduction of neural adhesions by biodegradable autocrosslinked hyaluronic acid gel after injury of peripheral nerves: an experimental study
    Xander Smit
    Department of Plastic and Reconstructive Surgery, Erasmus MC University Medical Center Rotterdam, The Netherlands
    J Neurosurg 101:648-52. 2004
    ..The authors aimed to develop an objective biomechanical method of quantifying nerve adhesions and to use this technique for the evaluation of the efficacy of an autocrosslinked hyaluronic acid (HA) gel as ..
  39. ncbi Complications and feasibility of laparoscopic adhesiolysis in patients with chronic abdominal pain. A retrospective study
    D J Swank
    Department of Surgery, Groene Hart Hospital, Gouda, PO Box 1098, 2800 BB Gouda, The Netherlands
    Surg Endosc 16:1468-73. 2002
    ..A retrospective study was done to determine whether laparoscopic adhesiolysis benefits patients with chronic abdominal pain. Factors that influence complications and feasibility of laparoscopic adhesiolysis were evaluated...
  40. ncbi In vivo performance of antibiotic embedded electrospun PCL membranes for prevention of abdominal adhesions
    N Bolgen
    Chemical Engineering Department and Bioengineering Division and TUBITAK USAM Biyomedtek, Hacettepe University, Beytepe, Ankara, Turkey
    J Biomed Mater Res B Appl Biomater 81:530-43. 2007
    ..PCL) and their antibiotic containing forms by electrospinning, so as to prevent postsurgery induced abdominal adhesions in rats...
  41. ncbi Female infertility and free radicals: potential role in adhesions and endometriosis
    Zeynep Alpay
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, C S Mott Center for Human Growth and Development, Wayne State University, Detroit, Michigan 48201, USA
    J Soc Gynecol Investig 13:390-8. 2006
    ..Peritoneal adhesions and endometriosis are relatively commonly identified in women, and are known to be associated with infertility ..
  42. ncbi Evaluation of laparoscopic adhesiolysis for the treatment of experimentally induced adhesions in pony foals
    Ludovic P Boure
    Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Canada
    Am J Vet Res 63:289-94. 2002
    To assess the efficacy of laparoscopic adhesiolysis in the treatment of experimentally induced adhesions in foals.
  43. ncbi Complete hypopharyngeal obstruction by mucosal adhesions: a complication of intensive chemoradiation for advanced head and neck cancer
    Elizabeth J Franzmann
    Department of Otolaryngology, University of Miami Sylvester Comprehensive Cancer Center, 1475 NW 12th Avenue, Suite 4037, Miami, FL 33136, USA
    Head Neck 28:663-70. 2006
    ..seen with complete obstruction of the hypopharynx distal to the site of the primary cancer, and in whom we postulate that the obstruction was caused by separable mucosal adhesions rather than obliteration by a mature fibrous stricture.
  44. ncbi Prevention of gynaecological adhesions using haemostatic fleece in a rabbit model
    G Dickneite
    ZLB Behring GmbH, Marburg, Germany
    J Int Med Res 34:505-13. 2006
    ..After 14 days, the animals were killed and examined for the presence of adhesion. The lengths of any adhesions were measured and the severity was recorded as a score (0, no adhesion; 1, adhesion easy to lyse; 2, adhesion ..
  45. doi Two experimental models for generating abdominal adhesions
    Wolfgang B Gaertner
    Department of Surgery, University of Minnesota, 420 Delaware St SE, MMC 195, Minneapolis, MN 55455, USA
    J Surg Res 146:241-5. 2008
    To develop dependable rat models for generating abdominal adhesions that allow for objective evaluation and quantification.
  46. ncbi Adhesions caused by umbilical piercing
    Gary Ventolini
    Department of Obstetrics and Gynecology, Good Samaritan Hospital, Cincinnati, OH, USA
    J Am Assoc Gynecol Laparosc 10:281. 2003
    ..Diagnostic laparoscopy revealed an umbilical adhesion from the small bowel to the anterior abdominal wall. The patient removed the umbilical piercing but declined surgery for adhesiolysis...
  47. ncbi Long-term follow-up and cost analysis following surgery for small bowel obstruction caused by intra-abdominal adhesions
    B Tingstedt
    Department of Surgery, Lund University, Lund, Sweden
    Br J Surg 94:743-8. 2007
    This study examined the natural course of patients following surgery for small bowel obstruction (SBO) caused by abdominal adhesions. In addition, a cost analysis was performed.
  48. ncbi Effectiveness of treatment to prevent adhesions after abdominal surgery: an experimental evaluation in rats
    Cem Kaan Parsak
    Department of General Surgery, Cukurova University, School of Medicine, Adana, Turkey
    Adv Ther 24:796-802. 2007
    ..Ileal content was the leading cause of intraperitoneal adhesions in the first phase; in the second phase, in group 1, 2 mL ileal content and 5 mL povidone-iodine (10%) were used;..
  49. ncbi Intraobserver and interobserver reliability of videotaped laparoscopy evaluations for endometriosis and adhesions
    Philomeen T M Weijenborg
    Department of Gynecology, Leiden University Medical Center, Leiden, The Netherlands
    Fertil Steril 87:373-80. 2007
    ..To determine the intra- and interobserver reliability of evaluations during videotaped laparoscopy, with real-time laparoscopy as the "gold standard."..
  50. ncbi The effects of a combination of hyaluronic and amniotic membrane on the formation of peritendinous adhesions after flexor tendon surgery in chickens
    G Y Ozgenel
    Department of Plastic and Reconstructive Surgery, Division of Hand Surgery, Uludag University Medical School, Bursa, Turkey
    J Bone Joint Surg Br 86:301-7. 2004
    ..the effects of the intra-operative application of a combination of hyaluronic acid and amniotic membrane on adhesions in the flexor tendons of a chicken model...
  51. ncbi The preventive effect of Rofecoxib in postoperative intraperitoneal adhesions
    M Aldemir
    Department of General Surgery, Dicle University, Faculty of Medicine, Diyarbakir, Turkey
    Acta Chir Belg 104:97-100. 2004
    ..Therefore, we planned this study to experimentally evaluate the effects of Rofecoxib, the selective cyclo-oxygenase-2 inhibitor, in postoperative intraperitoneal adhesions in an animal model.
  52. ncbi Preoperative ultrasound to predict infraumbilical adhesions: a study of diagnostic accuracy
    Frank F Tu
    Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Am J Obstet Gynecol 192:74-9. 2005
    The purpose of this study was to determine the test characteristics of preoperative abdominal ultrasound in predicting infraumbilical adhesions in women.
  53. ncbi Camptothecin-loaded films for the prevention of postsurgical adhesions
    J Cashman
    ARC Pharmaceuticals Inc, University of British Columbia, 102 2386 East Mall, Vancouver BC, Canada
    Inflamm Res 53:355-62. 2004
    ..The purpose of this work was to investigate the local application of camptothecin (CPT), a drug with anti-inflammatory, antiproliferative and antiangiogenic properties, as an inhibitor of surgical adhesion formation in rats...
  54. ncbi Can arthrocentesis release intracapsular adhesions? Arthroscopic findings before and after irrigation under sufficient hydraulic pressure
    Shinya Yura
    Oral and Maxillofacial Surgery, Tonami General Hospital, 1 6 Shintomi cho, Tonami City, Toyama ken 939 1395, Japan
    J Oral Maxillofac Surg 61:1253-6. 2003
    To investigate the effect of release of intra-articular adhesions of arthrocentesis, we examined patients with closed lock of the temporomandibular joint by arthroscopy before and after irrigation.
  55. pmc Role of laparoscopy in identifying the clinical significance and cause of adhesions and chronic pelvic pain: a retrospective review at the Kiel School of Gynecological Endoscopy
    Liselotte Mettler
    Kiel School of Gynecological Endoscopy, Department of Obstetrics and Gynecology, University Hospitals Schleswig Holstein, Campus Kiel, Michaelisstrasse 16, Kiel 24105, Germany
    JSLS 11:303-8. 2007
    We sought to define the role of laparoscopy in identifying the clinical significance, cause, and association between adhesions and chronic pelvic pain.
  56. ncbi Expression of connective tissue growth factor in intra-abdominal adhesions
    Klaus Thaler
    Department of Colorectal Surgery, Cleveland Clinic Florida, 2950 Cleveland Clinic Boulevard, Weston, FL 33331, USA
    Dis Colon Rectum 45:1510-9. 2002
    ..The aim of our study was to determine the expression pattern of connective tissue growth factor in postoperative intra-abdominal adhesions.
  57. ncbi Impact of adhesions in colorectal surgery
    R Bhardwaj
    Department of Surgery, Darent Valley Hospital, Kent, UK
    Colorectal Dis 9:45-53. 2007
    The extent of the problem of adhesions is considerable and poses a significant burden on healthcare systems, the workload of surgeons and the lives of patients...
  58. ncbi Mast cells facilitate local VEGF release as an early event in the pathogenesis of postoperative peritoneal adhesions
    Ronan A Cahill
    Department of Academic Surgery, Cork University Hospital, Ireland
    Surgery 140:108-12. 2006
    ..Peritoneal mast cells are likely to initiate this process, whereas vascular permeability/endothelial growth factor (VEGF) may facilitate the degree to which subsequent adhesion formation occurs...
  59. ncbi Prevention of peritendinous adhesions following flexor tendon injury with seprafilm
    Adnan Menderes
    Dokuz Eylul University, Faculty of Medicine, Department of Plastic, Reconstructive and Aesthetic Surgery, Izmir, Turkey
    Ann Plast Surg 53:560-4. 2004
    Peritendinous adhesions are the most important complication of flexor tendon injury. In this study, Seprafilm was used for the prevention of peritendinous adhesions following flexor tendon repair...
  60. ncbi The effect of immunosuppression on peritoneal adhesions formation after small bowel transplantation in rats
    Nir Wasserberg
    Department of Surgery, University of Miami School of Medicine, Miami, Florida, USA
    J Surg Res 141:294-8. 2007
    ..The purpose of the study was to investigate the influence of immunosuppression on peritoneal adhesion formation after intestinal transplantation in rats...
  61. doi The incidence and morbidity of adhesions after treatment of neonates with gastroschisis and omphalocele: a 30-year review
    Floortje C van Eijck
    Department of General Surgery, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Pediatr Surg 43:479-83. 2008
    ..Knowledge of its incidence and potential risk factors in a well-documented group with strict follow-up is needed to guide preventive measures...
  62. ncbi Reduction of postoperative perineural adhesions by Hyaloglide gel: an experimental study in the rat sciatic nerve
    Phong Dam-Hieu
    Experimental Neurosurgery Laboratory, Centre Hospitalier Universitaire de Bicetre, Faculte de Medecine Paris Sud, Le Kremlin Bicetre, France
    Neurosurgery 56:425-33; discussion 425-33. 2005
    ..To assess the effects of Hyaloglide gel (or auto-cross-linked polysaccharide [ACP] gel; Fidia Advanced Biopolymers, Abano Terme, Italy), a hyaluronan-derivative polymer, on peripheral nerve scarring and nerve regeneration...
  63. ncbi Endometrial thickness measured by ultrasound scan in women with uterine outlet obstruction due to intrauterine or upper cervical adhesions
    Sin Ting Lo
    Department of Obstetrics and Gynaecology, Queen Elizabeth II Research Institute for Mothers and Infants, University of Sydney, NSW 2006 Australia
    Hum Reprod 23:306-9. 2008
    A subgroup of women with Asherman's syndrome has adhesions of limited extent completely blocking the lower uterine cavity or upper cervix, whereas the upper endometrium remains normal. Haematometra are rarely found in these women...
  64. ncbi Ovarian endometrioma: postoperative adhesions following bipolar coagulation and suture
    M Pellicano
    Department of Obstetrics and Gynecology, University of Naples Federico II, Naples, Italy
    Fertil Steril 89:796-9. 2008
    To compare bipolar coagulation and suturing of the ovary in terms of postoperative ovarian adhesions after laparoscopic ovarian cystectomy for endometriosis.
  65. ncbi The effect of resveratrol on surgery-induced peritoneal adhesions in an experimental model
    Gokhan Sogutlu
    General Surgery Department, Inonu University Medical School, Malatya, Turkey
    Cell Biochem Funct 25:217-20. 2007
    ..001, respectively). Introduction of resveratrol into the peritoneal cavity at the time of surgery reduced adhesion formation effectively in this model. Resveratrol probably acts through reduction of lipid peroxidation products...
  66. ncbi Surgical adhesions: a timely update, a great challenge for the future
    Andrew K Davey
    Sansom Institute, University of South Australia, Adelaide, South Australia
    J Minim Invasive Gynecol 14:15-22. 2007
    ..While these strategies have provided some success, none have yet proved totally successful in abolishing adhesions. Further research to ensure that adhesion prevention is optimal is therefore essential.
  67. ncbi Effect of oral D-penicillamine vs. colchicine on experimentally induced peritoneal adhesions in rats
    Saman Nikeghbalian
    Shiraz Organ Transplantation Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
    Fertil Steril 88:1187-9. 2007
    ..To evaluate the effects of d-penicillamine on prevention or reduction of adhesion band formation and to compare its effects with those of colchicine in an animal model...
  68. pmc Polymers in the prevention of peritoneal adhesions
    Yoon Yeo
    School of Pharmacy and Pharmaceutical Sciences, Weldon School of Biomedical Engineering, Purdue University, West Lafayelte IN, USA
    Eur J Pharm Biopharm 68:57-66. 2008
    Peritoneal adhesions are serious complications of surgery, and can result in pain, infertility, and potentially lethal bowel obstruction...
  69. ncbi Prevention of intraperitoneal adhesions by intraperitoneal lavage and intraperitoneal 5-fluorouracil: experimental studies
    Sophie R Pestieau
    The Washington Cancer Institute, Washington Hospital Center, District of Columbia 20010, USA
    Int Surg 87:195-200. 2002
    Postoperative adhesions remain the leading cause of small bowel obstruction. Peritoneal adhesions were induced in 180 rats by scraping the cecum and burning the adjacent parietal peritoneum by electrocoagulation...
  70. ncbi Effectiveness of auto-cross-linked hyaluronic acid gel in the prevention of intrauterine adhesions after hysteroscopic adhesiolysis: a prospective, randomized, controlled study
    Giuseppe Acunzo
    Department of Obstetrics and Gynaecology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Hum Reprod 18:1918-21. 2003
    A prospective, randomized, controlled study was performed to assess the efficacy of auto-cross-linked hyaluronic acid (ACP) gel in preventing the development of intrauterine adhesions following hysteroscopic adhesiolysis.
  71. pmc The role of laparoscopic adhesiolysis in the treatment of patients with chronic abdominal pain or recurrent bowel obstruction
    Vafa Shayani
    Department of Surgery, Loyola University Medical Center, Maywood, IL 60153, USA
    JSLS 6:111-4. 2002
    ..Laparoscopic adhesiolysis may provide relief of symptoms in patients with prior abdominal surgery with chronic abdominal pain or recurrent bowel obstruction...
  72. ncbi Temporary ovarian suspension at laparoscopy for prevention of adhesions
    Mostafa I Abuzeid
    Division of Reproductive Endocrinology, Hurley Medical Center, Two Hurley Plaza, Suite 101, Flint, MI 48503, USA
    J Am Assoc Gynecol Laparosc 9:98-102. 2002
    ..In four patients (80%), we found no evidence of recurrent adhesions. The remaining 20% had minimal adhesions...
  73. ncbi Inhibition of CCL1-CCR8 interaction prevents aggregation of macrophages and development of peritoneal adhesions
    Akiyoshi Hoshino
    Department of Medical Ecology and Informatics, International Medical Center of Japan, Tokyo, Japan
    J Immunol 178:5296-304. 2007
    Peritoneal adhesions are a significant complication of surgery and visceral inflammation; however, the mechanism has not been fully elucidated...
  74. ncbi Prevention of postoperative abdominal adhesions by a novel, glycerol/sodium hyaluronate/carboxymethylcellulose-based bioresorbable membrane: a prospective, randomized, evaluator-blinded multicenter study
    Zane Cohen
    Department of Surgery, Mount Sinai Hospital, University of Toronto, Toronto, Canada
    Dis Colon Rectum 48:1130-9. 2005
    Postoperative abdominal adhesions are associated with significant morbidity and mortality, placing a substantial burden on healthcare systems worldwide...
  75. ncbi Effect of reactive oxygen species scavengers, antiinflammatory drugs, and calcium-channel blockers on carbon dioxide pneumoperitoneum-enhanced adhesions in a laparoscopic mouse model
    M M Binda
    Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Herestraat 49 Bus 611, B3000, Leuven, Belgium
    Surg Endosc 21:1826-34. 2007
    Postoperative adhesions are a clinical problem. They can cause female infertility, intestinal obstruction, chronic pelvic pain, and difficulties at the time of reoperation...
  76. ncbi Retroperitoneoscopic subcapsular nephrectomy for infective nonfunctioning kidney with dense perinephric adhesions
    Zhang Xu
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
    BJU Int 94:1329-31. 2004
    To evaluate the feasibility and clinical efficacy of retroperitoneoscopic subcapsular nephrectomy for infective nonfunctioning kidneys with dense perinephric adhesions.
  77. ncbi Laparoscopic lysis of adhesions
    Ritu Chopra
    Center for Minimally Invasive Surgery, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Am Surg 69:966-8. 2003
    ..01), bowel resection (P < 0.01) and op-time (P < 0.003). Laparoscopic release of adhesions is a viable option in the surgical management of small bowel obstruction...
  78. ncbi Effectiveness of auto-crosslinked hyaluronic acid gel in the prevention of intrauterine adhesions after hysteroscopic surgery: a prospective, randomized, controlled study
    Maurizio Guida
    Department of Obstetrics and Gynecology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Hum Reprod 19:1461-4. 2004
    A prospective, randomized, controlled study was performed to assess the efficacy of auto-crosslinked hyaluronic acid (ACP) gel to prevent the development of de-novo intrauterine adhesions following hysteroscopic surgery.
  79. ncbi Detection of peritoneal adhesions using ultrasound examination for the evaluation of an innovative intraperitoneal mesh
    C Aube
    Department of Radiology, University Hospital Angers, 49033 Angers Cedex, France
    Surg Endosc 18:131-5. 2004
    ..study, we evaluated the efficiency of a specific ultrasound examination in detecting postoperative bowel adhesions and assessed the adhesion rate associated with the intraperitoneal use of Parietex composite mesh (polyester ..
  80. ncbi Expression of transforming growth factor beta isoform mRNA in injured peritoneum that healed with adhesions and without adhesions and in uninjured peritoneum
    Michael L Freeman
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Detroit Medical Center, Wayne State University, Detroit, Michigan, USA
    Fertil Steril 80:708-13. 2003
    ..the mRNA levels of transforming growth factor beta (TGF-beta) isoforms 1, 2, and 3 among surgically injured peritoneum that healed with adhesions, surgically injured peritoneum that healed without adhesions, and uninjured peritoneum.
  81. pmc Prevention of peritendinous adhesions using a hyaluronan-derived hydrogel film following partial-thickness flexor tendon injury
    Yanchun Liu
    Center for Therapeutic Biomaterials and Department of Medicinal Chemistry, The University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, Utah 84108 1257, USA
    J Orthop Res 26:562-9. 2008
    Peritendinous adhesions are an important complication of flexor tendon injury. Three hyaluronan (HA)-derived biomaterials were evaluated for the reduction of peritendinous adhesions following partial-thickness tendon injury in rabbits...
  82. ncbi Peritoneal molecular environment, adhesion formation and clinical implication
    Nasser Chegini
    Division of Reproductive Endocrinology and Infertility, Institute for Wound Research, Department of Obstetrics and Gynecology, University of Florida, Gainesville, FL 32610, USA
    Front Biosci 7:e91-115. 2002
    Whether induced by infection, inflammation, ischemia, and/or surgical injury, peritoneal adhesions are the leading cause of pelvic pain, bowel obstruction and infertility...
  83. ncbi Epidemiology of adhesions: the burden
    Michael C Parker
    Darent Valley Hospital, Dartford, Kent DA2 8DA
    Hosp Med 65:330-6. 2004
    ..The clinical consequences and burden of disease are reviewed...
  84. pmc Prevention of adhesion to prosthetic mesh: comparison of different barriers using an incisional hernia model
    Martijne van 't Riet
    Department of General Surgery, Erasmus University Medical Centre, Rotterdam Dijkzigt, The Netherlands
    Ann Surg 237:123-8. 2003
    ..To assess whether use of antiadhesive liquids or coatings could prevent adhesion formation to prosthetic mesh...
  85. ncbi Cine magnetic resonance imaging vs high-resolution ultrasonography for detection of adhesions after laparoscopic and open incisional hernia repair: a matched pair pilot analysis
    T Mussack
    Department of Surgery Innenstadt, Klinikum der Universitat Munchen, Nussbaumstrasse 20, 80336, Munchen, Germany
    Surg Endosc 19:1538-43. 2005
    Intraabdominal adhesions represent nonspecific complications before or after laparoscopic or open incisional hernia repair...
  86. ncbi Long-term outcome, adhesions, and quality of life after laparoscopic and open surgical therapies for acute abdomen: follow-up of a prospective trial
    W D Majewski
    Department of General and Transplantation Surgery and Faculty of Nursing, Pomeranian Medical University, Szczecin, Poland
    Surg Endosc 19:81-90. 2005
    The objective of this study was to determine the long-term outcome of laparoscopic and open therapies for acute abdomen, and to assess the patients postoperative quality of life, with special attention to adhesions.
  87. ncbi Seprafilm reduces adhesions to polypropylene mesh and increases peritoneal hydroxyproline
    Irfan Altuntas
    Department of Biochemistry and Clinical Biochemistry, Suleyman Demirel University School of Medicine, Isparta, Turkey
    Am Surg 68:759-61. 2002
    ..mesh is an effective and widely used material in repairing abdominal wall defects, but it causes dense adhesions when in contact with abdominal viscera directly...
  88. ncbi Adhesions in patients with chronic pelvic pain: a role for adhesiolysis?
    Ahmad Hammoud
    Department of Obstetrics and Gynecology, Wayne State University The Detroit Medical Center, Detroit, Michigan, USA
    Fertil Steril 82:1483-91. 2004
    To review the relation between adhesions and pelvic pain and the effectiveness of adhesiolysis in pain control.
  89. pmc A randomized controlled trial of 0.5% ferric hyaluronate gel (Intergel) in the prevention of adhesions following abdominal surgery
    Choong Leong Tang
    Department of Colorectal Surgery, Singapore General Hospital, Singapore
    Ann Surg 243:449-55. 2006
    ..Intergel is a hyaluronate-based gel that reduces the incidence of postoperative adhesions when added to the peritoneal cavity before closure in gynecologic surgery...
  90. ncbi The role of intra-peritoneal honey administration in preventing post-operative peritoneal adhesions
    Erhan Aysan
    General Surgery Department, SSK Istanbul Educational Hospital, Istanbul, Turkey
    Eur J Obstet Gynecol Reprod Biol 104:152-5. 2002
    ..Because peritoneal healing is a kind of wound healing process we hypothesised that post-operative peritoneal adhesions (PPA) may be reduced with intra-peritoneal honey administration.
  91. ncbi An evaluation of low molecular weight heparin and hyperbaric oxygen treatment in the prevention of intra-abdominal adhesions and wound healing
    Soykan Arikan
    General Surgery Clinic, Haseki Education and Research Hospital, Istanbul, Turkey
    Am J Surg 189:155-60. 2005
    Abdominal surgery can lead to intra-abdominal adhesions with significant morbidity and mortality...
  92. ncbi Comparison of the reduction of postoperative adhesions by two barriers, one solution, and two pharmacologic agents in the rat uterine model
    Tevfik Yoldemir
    Second Obstetrics and Gynecology Clinic, Sisli Etfal Training and Research Hospital, Istanbul, Turkey
    Fertil Steril 78:335-9. 2002
    ..To evaluate the effects of two barriers, one solution, and two pharmacologic agents, in single or in combined use, for preventing postsurgical adhesion formation in the rat model...
  93. ncbi Preventing intra-abdominal adhesions with polylactic acid film: an animal study
    Shmuel Avital
    Division of Colon and Rectal Surgery, Department of Surgery, University of Miami School of Medicine, Miami, Florida 33136, USA
    Dis Colon Rectum 48:153-7. 2005
    The aim of this study was to evaluate the efficacy of an absorbable polylactic acid film (SurgiWrap) in preventing postoperative intra-abdominal adhesions in an animal model.
  94. pmc Adhesions and adhesiolysis: the role of laparoscopy
    Stephen M Kavic
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06512, USA
    JSLS 6:99-109. 2002
    b>Adhesions commonly result from abdominal and pelvic surgical procedures and may result in intestinal obstruction, infertility, chronic pain, or complicate subsequent operations...
  95. ncbi Phospholipids reduce adhesion formation in the rabbit uterine horn model
    Stefan A Müller
    Department of Surgery, Medical Faculty, Rhenish Westphalian Technical University, Aachen, Germany
    Fertil Steril 77:1269-73. 2002
    To access the ability of intraperitoneal phospholipids to reduce adhesions in a standardized model for gynecologic operations.
  96. pmc The prevention of peritoneal adhesions by in situ cross-linking hydrogels of hyaluronic acid and cellulose derivatives
    Taichi Ito
    Department of Chemical Engineering, Massachusetts Institute of Technology, 45 Carleton St, Cambridge, MA 02142, USA
    Biomaterials 28:975-83. 2007
    Post-operative peritoneal adhesions can cause pelvic pain, infertility, and potentially lethal bowel obstruction...
  97. ncbi Practicalities and costs of adhesions
    M S Wilson
    Department of Surgery, Christie Hospital, Manchester, UK
    Colorectal Dis 9:60-5. 2007
    In spite of postoperative adhesions being common there appears to be a reluctance to use anti-adhesion products routinely. This article compares the incidence of adhesions with other conditions in order to identify the level of risk...
  98. pmc Minimal adhesions to ePTFE mesh after laparoscopic ventral incisional hernia repair: reoperative findings in 65 cases
    Richard H Koehler
    Springfield Hospital, Springfield, Vermont 05156, USA
    JSLS 7:335-40. 2003
    ..involves intraabdominal placement of a synthetic mesh, and the possibility of formation of severe visceral adhesions to the prosthesis is a principal concern...
  99. ncbi The difficult patient in gastroenterology: chronic pelvic pain, adhesions, and sub occlusive episodes
    A A W Peters
    Department of Gynaecology, Leiden University Medical Centre, K 6 P, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Best Pract Res Clin Gastroenterol 21:445-63. 2007
    Chronic pelvic pain (CPP) with or without adhesions and symptoms of intestinal occlusion is a complex but relatively common complaint. The etiology and pathophysiology of CPP and adhesions are unclear, as is their possible relation...
  100. ncbi Midkine, a heparin-binding cytokine, plays key roles in intraperitoneal adhesions
    Kazuhiko Inoh
    Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Biochem Biophys Res Commun 317:108-13. 2004
    ..Therefore, midkine was concluded to play important roles in the formation of intraperitoneal adhesions, at least partly by promoting the migration of macrophages and neutrophils to the omentum.
  101. ncbi Laparoscopic compared with conventional treatment of acute adhesive small bowel obstruction
    C Wullstein
    Chirurgische Abteilung, Allgemeines Krankenhaus Barmbek, Hamburg, Germany
    Br J Surg 90:1147-51. 2003
    Although laparoscopy may be associated with fewer intra-abdominal adhesions and quicker recovery of bowel function, it remains unclear whether patients with acute small bowel obstruction (SBO) might benefit from laparoscopic techniques.

Research Grants89

  1. Laser-Activated Collagen Adhesives for Herniorrhaphy
    Barbara Soltz; Fiscal Year: 2006
    ..In fact, adhesions represent a significant source of morbidity and mortality and are a common cause of small bowel obstruction in ..
  2. Obstruction-initiated mechanotranscription in colonic smooth muscle cells
    Xuan Zheng Shi; Fiscal Year: 2009
    ..Numerous pathological conditions, including adhesions, carcinomas, and Hirschsprung's disease, result in obstruction in the gut...
  3. Pathogen-host Interactions that Remodel the Cytoskeleton
    Tina Izard; Fiscal Year: 2010
    ..actin cytoskeleton by binding to other key partners such as talin, which binds to integrin receptors in focal adhesions, or to a- actinin, which plays key roles in adherens junctions...
  4. Focal Adhesion Modulation of IL-1 Signaling: Importance in Pulmonary Fibrosis
    GREGORY DOWNEY; Fiscal Year: 2009
    ..Our studies to date have determined that in fibroblasts, IL-1-induced signaling requires focal adhesions (FA) and that IL-1 signals are dissipated by FA dispersing peptides that we have developed...
  5. Aqueous humor dynamics studies in vivo and in vitro
    PAUL LEON KAUFMAN; Fiscal Year: 2010
    ..be enhanced by ILK, PI3K and Src kinase inhibitors, which have been shown to alter the cytoskeleton and cellular adhesions of trabecular meshwork (TM) cells in culture...
  6. Aqueous humor dynamics studies in vivo and in vitro
    Paul Kaufman; Fiscal Year: 2009
    ..be enhanced by ILK, PI3K and Src kinase inhibitors, which have been shown to alter the cytoskeleton and cellular adhesions of trabecular meshwork (TM) cells in culture...
  7. Engineered Biologics for Repair of Abdominal Wall Musculofascia
    Anshu B Mathur; Fiscal Year: 2010
    ..tissue flaps), which are limited in supply, synthetic materials such as polypropylene (PP mesh) that cause bowel adhesions, and naturally derived degradable extracellular matrix (ECM) scaffolds (acellular dermis, small intestine ..
  8. Focal Adhesion Modulation of IL-1 Signaling: Importance in Pulmonary Fibrosis
    GREGORY DOWNEY; Fiscal Year: 2009
    ..Our studies to date have determined that in fibroblasts, IL-1-induced signaling requires focal adhesions (FA) and that IL-1 signals are dissipated by FA dispersing peptides that we have developed...
  9. Focal Adhesion Modulation of IL-1 Signaling: Importance in Pulmonary Fibrosis
    GREGORY PAUL DOWNEY; Fiscal Year: 2010
    ..Our studies to date have determined that in fibroblasts, IL-1-induced signaling requires focal adhesions (FA) and that IL-1 signals are dissipated by FA dispersing peptides that we have developed...
  10. Genetic Analysis of FAK Activity
    David D Schlaepfer; Fiscal Year: 2010
    ..Signals generated by integrins at cell attachment sites termed focal adhesions are mediated by the recruitment of cytoskeletal and signaling proteins in a manner that remain under ..
  11. Endogenous Hormones and Risk of Endometriosis
    Stacey Missmer; Fiscal Year: 2007
    ..The consequence is the development of adhesions, scarring, and painful inflammation...
  12. The role of CTGF in bone cell development and function
    STEVEN POPOFF; Fiscal Year: 2009
    ..We have demonstrated that osteoblasts attach to CTGF via the av5 integrin, resulting in the formation of focal adhesions, cytoskeletal reorganization and the activation of FAK and Erk...
  13. Endogenous Hormones and Risk of Endometriosis
    Stacey Missmer; Fiscal Year: 2009
    ..The consequence is the development of adhesions, scarring, and painful inflammation...
  14. Biomimetic Scaffolds for Abdominal Wall Repair
    Anshu Mathur; Fiscal Year: 2007
    ..tissue flaps), which are limited in supply, synthetic materials such as polypropylene (PP mesh) that cause bowel adhesions, and naturally derived degradable extracellular matrix (ECM) scaffolds (AllodermZ, SurgisisZ) that are animal ..
  15. Obstruction-initiated mechanotranscription in colonic smooth muscle cells
    Xuan Zheng Shi; Fiscal Year: 2010
    ..Numerous pathological conditions, including adhesions, carcinomas, and Hirschsprung's disease, result in obstruction in the gut...
  16. SNP Analysis of Endometriosis Candidate Genes
    Idhaliz Flores; Fiscal Year: 2006
    ..This condition is characterized by inflammation, fibrosis, adhesions, and chocolate cysts, which result in chronic pelvic pain, pain during intercourse (dyspareunia), painful ..
  17. Role of the Tail Domain in Vinculin Function
    Sharon L Campbell; Fiscal Year: 2010
    This proposal is focused on vinculin, a cytoskeletal protein that is a prominent component of focal adhesions and adherens junctions...
  18. Role of the Tail Domain in Vinculin Function
    Sharon Campbell; Fiscal Year: 2009
    This proposal is focused on vinculin, a cytoskeletal protein that is a prominent component of focal adhesions and adherens junctions...
  19. Xenobiotics and Breast Epithelial Cell-ECM Signaling
    Raymond Novak; Fiscal Year: 2005
    ..Cells are linked to the ECM via integrin-containing focal adhesions. Other types of structures that link cells to each other or to the ECM include adherens junctions and desmosomes...
  20. Quantitative Analysis of Chemotactic Motility Cycle of Ameboid Cells
    JUAN CARLOS contact LASHERAS; Fiscal Year: 2010
    ..of actin-directed motors, F-actin regulation, actin crosslinking, motor protein-mediated contractility, and cell adhesions. However, precise knowledge of the biophysical coordination of these processes has been limited by the lack of ..
  21. G Proteins and Endothelial Barrier Regulation
    Tatyana Voyno Yasenetskaya; Fiscal Year: 2004
    ..that G-alpha13 protein interacts with the actin-binding protein, radixin, implicated in the assembly of focal adhesions and actin filaments...
  22. A new absorbable mesh for hernia repair
    David Martin; Fiscal Year: 2007
    ..The absorbability of the mesh would reduce late term fistula and risk of infection and possibly tissue adhesions. Greater flexibility of the fiber will reduce mesh stiffness and eventual absorption will reduce the stiffness ..
  23. Molecular Function of Palladin's Ig Domains in Cell Adhesion and Motility
    Carol A Otey; Fiscal Year: 2010
    Both cell-cell and cell-matrix adhesions require the participation of the actin cytoskeleton...
  24. Molecular Function of Palladin's Ig Domains in Cell Adhesion and Motility
    Carol Otey; Fiscal Year: 2009
    Both cell-cell and cell-matrix adhesions require the participation of the actin cytoskeleton...
  25. STRUCTURE AND FUNCTION OF PAXILLIN
    Christopher Turner; Fiscal Year: 1999
    ..in targeting paxillin to specialized sites of cell attachment to the extracellular matrix known as focal adhesions. Proteins interacting with the individual domains of paxillin will be identified and characterized...
  26. Treatment of Endometriosis-Associated Pelvic Pain
    David Guzick; Fiscal Year: 2007
    ..Surgical treatment of endometriosis with laparoscopic excision of implants and lysis of adhesions is often successful in reducing pain in the short term...
  27. Mechanisms Driving Cortical Cytoskeleton Dynamics in Cancer Cell Invasion
    Kathryn M Eisenmann; Fiscal Year: 2010
    ..ACM is distinct from the mesenchymal-type of cell motility involving focal adhesions and matrix metalloproteinases (MMPs);ACM is a specialized mode of cancer cell migration and is proposed to play ..
  28. STRUCTURAL DYNAMICS OF VINCULIN IN ADHESION JUNCTIONS
    Tina Izard; Fiscal Year: 2007
    ..cytoskeleton by binding to key scaffold proteins, including talin, which binds to integrin receptors in focal adhesions, and to a-actinin and a-catenin, which bind to cadherins in adherens junctions...
  29. ABNORMAL BIGH3 AGGREGATIONS IN CORNEAL DYSTROPHIES
    Andrew J W Huang; Fiscal Year: 2010
    ..These dystrophies are found to have abnormal stromal deposits and related poor epithelial adhesions with resultant painful corneal erosions. Corneal transplantation is often needed to restore corneal clarity...
  30. Growth Hormone Regulation of SH2B1
    Christin Carter Su; Fiscal Year: 2010
    ..g., focal adhesions, lamellipodia, cytoplasm, nucleus)...
  31. Molecular Basis of ILK/PINCH Function in Cell Adhesion
    Jun Qin; Fiscal Year: 2010
    ..signals into intracellular compartment leading to the formation of large protein complexes called focal adhesions (FAs) that connect integrin cytoplasmic tails (CTs) to the actin cytoskeleton. This latter step, i.e...
  32. Role of Surface Roughness in Regulating Tumor Cell Behavior
    Sarah Glover; Fiscal Year: 2009
    ..less and more tumorigenic cells cultured on a "peak-like" matrix actually had higher Rho activity and more focal adhesions as revealed by talin staining...
  33. INTEGRIN INTRACELLULAR FUNCTION
    SUSAN LAFLAMME; Fiscal Year: 2009
    ..Preliminary studies demonstrate that adhesion-induced FAK activation, Src signaling and the formation of focal adhesions are inhibited in cells adhered by the mutant integrin...
  34. ROLE OF PYK2 IN REGULATING OSTEOCLASTIC BONE RESORPTION
    Wen Cheng Xiong; Fiscal Year: 2005
    ..They are similar to focal adhesions in fibroblasts...
  35. Actions of the Sodium-Hydrogen Exchanger Subtype, NHE1
    DIANE BARBER; Fiscal Year: 2007
    ..for directed cell migration and are required for cell polarity, actin polymerization, and remodeling of focal adhesions. A novel DNHE1 in Drosophila that binds an ERM ortholog, and a novel DdNHE1 in Dictyostelium discoideum that is ..
  36. Image-Guided Surgery of Endocrine Glands and Their Tumors using Near-Infrared Flu
    John V Frangioni; Fiscal Year: 2010
    ..tissues, such as the thyroid gland and adrenal gland, can often be difficult to locate during surgery due to adhesions and overlying fascia...