adhesions

Summary

Summary: Pathological processes consisting of the union of the opposing surfaces of a wound.

Top Publications

  1. ncbi Consequences and complications of peritoneal adhesions
    H van Goor
    Department of Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Colorectal Dis 9:25-34. 2007
  2. ncbi Molecular characterization of postoperative adhesions: the adhesion phenotype
    Ghassan M Saed
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA
    J Am Assoc Gynecol Laparosc 11:307-14. 2004
  3. ncbi Prevention of adhesions by bioresorbable tissue barrier following laparoscopic intraabdominal mesh insertion
    M Mahir Ozmen
    Department of Surgery and Pathology, Ankara Numune Teaching and Research Hospital, Turkey
    Surg Laparosc Endosc Percutan Tech 12:342-6. 2002
  4. ncbi Prevention of peritoneal adhesions by intraperitoneal administration of vitamin E: an experimental study in rats
    Fernando de la Portilla
    Coloproctology Unit, Department of General Surgery, Hospital Juan Ramon Jimenez, Huelva, Spain
    Dis Colon Rectum 47:2157-61. 2004
  5. pmc Prevention of postsurgery-induced abdominal adhesions by electrospun bioabsorbable nanofibrous poly(lactide-co-glycolide)-based membranes
    Xinhua Zong
    Department of Chemistry, Stony Brook University, Stony Brook, New York 11794 3400, USA
    Ann Surg 240:910-5. 2004
  6. ncbi Fewer adhesions induced by laparoscopic surgery?
    C N Gutt
    Department of General, Visceral and Trauma Surgery, Ruprecht Karls University, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
    Surg Endosc 18:898-906. 2004
  7. ncbi Population-based study of the surgical workload and economic impact of bowel obstruction caused by postoperative adhesions
    J Kössi
    Department of Surgery, University of Turku, Turku, Finland
    Br J Surg 90:1441-4. 2003
  8. ncbi Macrophage and T-lymphocyte infiltrates in human peritoneal adhesions indicate a chronic inflammatory disease
    Marcel Binnebösel
    Department of Surgery, RWTH Aachen University Hospital, Pauwelsstr 30, 52074, Aachen, Germany
    World J Surg 32:296-304. 2008
  9. pmc In situ cross-linkable hyaluronan hydrogels containing polymeric nanoparticles for preventing postsurgical adhesions
    Yoon Yeo
    Department of Chemical Engineering and Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA
    Ann Surg 245:819-24. 2007
  10. ncbi In vivo performance of antibiotic embedded electrospun PCL membranes for prevention of abdominal adhesions
    N Bolgen
    Chemical Engineering Department and Bioengineering Division and TUBITAK USAM Biyomedtek, Hacettepe University, Beytepe, Ankara, Turkey
    J Biomed Mater Res B Appl Biomater 81:530-43. 2007

Research Grants

  1. Laser-Activated Collagen Adhesives for Herniorrhaphy
    Barbara Soltz; Fiscal Year: 2006
  2. Pathogen-host Interactions that Remodel the Cytoskeleton
    Tina Izard; Fiscal Year: 2010
  3. Nuclear-Cytoplasmic Shuttling of Foxc2 via 14-3-3 Determines Proximal Tubule Cell
    DIANA LYNNE GOLDEN; Fiscal Year: 2012
  4. Growth Hormone Regulation of SH2B1
    Christin Carter-Su; Fiscal Year: 2013
  5. Genetic Analysis of FAK Activity
    David D Schlaepfer; Fiscal Year: 2012
  6. Regulation of Fibronectin Matrix Assembly by uPAR
    PAULA J MC KEOWN-LONGO; Fiscal Year: 2012
  7. Ibuprofen and enteric neural crest precursor migration
    ELLEN MERRICK; Fiscal Year: 2013
  8. The Role of Leptin in Liver Fibrogenesis
    Frank A Anania; Fiscal Year: 2012
  9. Structure and function of stress fibers and cell adhesion sites
    Mary C Beckerle; Fiscal Year: 2013
  10. Role of the Tail Domain in Vinculin Function
    Sharon L Campbell; Fiscal Year: 2010

Detail Information

Publications255 found, 100 shown here

  1. ncbi Consequences and complications of peritoneal adhesions
    H van Goor
    Department of Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Colorectal Dis 9:25-34. 2007
    ..b>Adhesions to the ventral abdominal wall are responsible for the majority of trocar injuries...
  2. ncbi Molecular characterization of postoperative adhesions: the adhesion phenotype
    Ghassan M Saed
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA
    J Am Assoc Gynecol Laparosc 11:307-14. 2004
    ..To date, approaches to limit adhesions primarily have involved barriers to separate tissue during reepithelization...
  3. ncbi Prevention of adhesions by bioresorbable tissue barrier following laparoscopic intraabdominal mesh insertion
    M Mahir Ozmen
    Department of Surgery and Pathology, Ankara Numune Teaching and Research Hospital, Turkey
    Surg Laparosc Endosc Percutan Tech 12:342-6. 2002
    Intraabdominal adhesions represent a significant problem because of the morbidity associated with adhesive disease, including small bowel obstruction, difficulties in reoperative surgery, and possibly chronic pain...
  4. ncbi Prevention of peritoneal adhesions by intraperitoneal administration of vitamin E: an experimental study in rats
    Fernando de la Portilla
    Coloproctology Unit, Department of General Surgery, Hospital Juan Ramon Jimenez, Huelva, Spain
    Dis Colon Rectum 47:2157-61. 2004
    Previous studies have shown dietary supplements of vitamin E to reduce the incidence of postoperative peritoneal adhesions. The objective of this study was to show the effect of intramuscular or intraperitoneal administration of vitamin ..
  5. pmc Prevention of postsurgery-induced abdominal adhesions by electrospun bioabsorbable nanofibrous poly(lactide-co-glycolide)-based membranes
    Xinhua Zong
    Department of Chemistry, Stony Brook University, Stony Brook, New York 11794 3400, USA
    Ann Surg 240:910-5. 2004
    The objective of this study was to evaluate the efficacy of nonwoven bioabsorbable nanofibrous membranes of poly(lactideco-glycolide) for prevention of postsurgery-induced abdominal adhesions.
  6. ncbi Fewer adhesions induced by laparoscopic surgery?
    C N Gutt
    Department of General, Visceral and Trauma Surgery, Ruprecht Karls University, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
    Surg Endosc 18:898-906. 2004
    ..Laparoscopic surgery has potential theoretical advantages over open surgery in reducing the rate of adhesion formation, but very few comparative studies are available to prove this...
  7. ncbi Population-based study of the surgical workload and economic impact of bowel obstruction caused by postoperative adhesions
    J Kössi
    Department of Surgery, University of Turku, Turku, Finland
    Br J Surg 90:1441-4. 2003
    Intestinal obstruction is the most severe consequence of adhesion formation. This study examined the annual surgical workload and costs of intestinal obstruction caused by postoperative intra-abdominal adhesions.
  8. ncbi Macrophage and T-lymphocyte infiltrates in human peritoneal adhesions indicate a chronic inflammatory disease
    Marcel Binnebösel
    Department of Surgery, RWTH Aachen University Hospital, Pauwelsstr 30, 52074, Aachen, Germany
    World J Surg 32:296-304. 2008
    Peritoneal adhesions are common and lead to significant clinical morbidity and mortality. Besides various individual factors, notably the inflammatory response to peritoneal defects affects adhesion formation...
  9. pmc In situ cross-linkable hyaluronan hydrogels containing polymeric nanoparticles for preventing postsurgical adhesions
    Yoon Yeo
    Department of Chemical Engineering and Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA
    Ann Surg 245:819-24. 2007
    ..barrier method and drug delivery system ("hybrid system") for preventing postoperative peritoneal adhesions, which could combine the biocompatibility and ease of application of in situ cross-linkable hydrogels with the ..
  10. ncbi In vivo performance of antibiotic embedded electrospun PCL membranes for prevention of abdominal adhesions
    N Bolgen
    Chemical Engineering Department and Bioengineering Division and TUBITAK USAM Biyomedtek, Hacettepe University, Beytepe, Ankara, Turkey
    J Biomed Mater Res B Appl Biomater 81:530-43. 2007
    ..PCL) and their antibiotic containing forms by electrospinning, so as to prevent postsurgery induced abdominal adhesions in rats...
  11. ncbi Surgical adhesions: a timely update, a great challenge for the future
    Andrew K Davey
    Sansom Institute, University of South Australia, Adelaide, South Australia
    J Minim Invasive Gynecol 14:15-22. 2007
    ..While these strategies have provided some success, none have yet proved totally successful in abolishing adhesions. Further research to ensure that adhesion prevention is optimal is therefore essential.
  12. ncbi A comparison of two adjunctive treatments for intrauterine adhesions following lysis
    A A E Orhue
    Human Reproduction Research Programme, Unit Department of Obstetrics and Gynaecology, University of Benin Teaching Hospital, Benin City, Edo State, Nigeria
    Int J Gynaecol Obstet 82:49-56. 2003
    ..To assess which treatment modality has a better outcome: the use of an intrauterine contraceptive device or the Foley catheter balloon, for the adjunctive treatment of intrauterine adhesion (IUA) in patients presenting with infertility...
  13. ncbi Reduction of neural adhesions by biodegradable autocrosslinked hyaluronic acid gel after injury of peripheral nerves: an experimental study
    Xander Smit
    Department of Plastic and Reconstructive Surgery, Erasmus MC University Medical Center Rotterdam, The Netherlands
    J Neurosurg 101:648-52. 2004
    ..The authors aimed to develop an objective biomechanical method of quantifying nerve adhesions and to use this technique for the evaluation of the efficacy of an autocrosslinked hyaluronic acid (HA) gel as ..
  14. pmc Prevention of peritendinous adhesions using a hyaluronan-derived hydrogel film following partial-thickness flexor tendon injury
    Yanchun Liu
    Center for Therapeutic Biomaterials and Department of Medicinal Chemistry, The University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, Utah 84108 1257, USA
    J Orthop Res 26:562-9. 2008
    Peritendinous adhesions are an important complication of flexor tendon injury. Three hyaluronan (HA)-derived biomaterials were evaluated for the reduction of peritendinous adhesions following partial-thickness tendon injury in rabbits...
  15. ncbi The effects of anti-adhesion materials in preventing postoperative adhesion in abdominal cavity (anti-adhesion materials for postoperative adhesions)
    Mustafa Sahin
    Department of General Surgery, Selcuk University Meram Medical Faculty, Konya, Turkey
    Inflammation 30:244-9. 2007
    The purpose of this study was to compare the effects of anti-adhesion materials in postoperative adhesions.
  16. ncbi Comparative effectiveness of several agents for preventing postoperative adhesions
    Jehat Kutlay
    2nd General Surgery Department, SSK Ankara Teaching Hospital, Ankara 06090, Turkey
    World J Surg 28:662-5. 2004
    Postoperative adhesions (PAs) are usually clinically asymptomatic...
  17. ncbi In situ cross-linkable hyaluronic acid hydrogels prevent post-operative abdominal adhesions in a rabbit model
    Yoon Yeo
    Department of Chemical Engineering, 77 Massachusetts Avenue, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Biomaterials 27:4698-705. 2006
    ..the efficacy of an in situ cross-linked hyaluronic acid hydrogel (HAX) in preventing post-surgical peritoneal adhesions, using a rabbit sidewall defect-cecum abrasion model...
  18. ncbi Modulation of the expression of tissue plasminogen activator and its inhibitor by hypoxia in human peritoneal and adhesion fibroblasts
    Ghassan M Saed
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, and the C S Mott Center for Human Growth and Development, Wayne State University, Detroit, Michigan 48201, USA
    Fertil Steril 79:164-8. 2003
    ..To determine whether normal peritoneal and adhesion fibroblasts express tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI-I) and whether their expression is regulated by oxygen...
  19. pmc Adhesions in a murine flexor tendon graft model: autograft versus allograft reconstruction
    Sys Hasslund
    The Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA
    J Orthop Res 26:824-33. 2008
    Reconstruction of flexor tendons often results in adhesions that compromise joint flexion. Little is known about the factors involved in the formation of flexor tendon graft adhesions...
  20. ncbi Intrauterine adhesions after conservative and surgical management of spontaneous abortion
    Wing Hung Tam
    Department of Obstetrics and Gynaecology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    J Am Assoc Gynecol Laparosc 9:182-5. 2002
    To determine the frequency of intrauterine adhesions (IUA) after conservative management, medical evacuation, and surgical evacuation for spontaneous abortion.
  21. ncbi Prevention of abdominal adhesions--present state and what's beyond the horizon?
    B Tingstedt
    Department of Surgery, Lund University, Lund, Sweden
    Eur Surg Res 39:259-68. 2007
    Intra-abdominal adhesions are normally found after most surgical procedures...
  22. ncbi Evaluation of hyaluronic acid sheet for the prevention of postlaminectomy adhesions
    Tsuyoshi Kato
    Department of Spinal and Orthopaedic Surgery, Tokyo Medical and Dental University, Graduate School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 5819, Japan
    Spine J 5:479-88. 2005
    ..Hyaluronic acid (HA) solution and gel have been reported to be effective in preventing adhesions postlaminectomy; however, neither has been used clinically after spinal surgery.
  23. ncbi Inhibition of CCL1-CCR8 interaction prevents aggregation of macrophages and development of peritoneal adhesions
    Akiyoshi Hoshino
    Department of Medical Ecology and Informatics, International Medical Center of Japan, Tokyo, Japan
    J Immunol 178:5296-304. 2007
    Peritoneal adhesions are a significant complication of surgery and visceral inflammation; however, the mechanism has not been fully elucidated...
  24. ncbi Prevention of peritendinous adhesions following flexor tendon injury with seprafilm
    Adnan Menderes
    Dokuz Eylul University, Faculty of Medicine, Department of Plastic, Reconstructive and Aesthetic Surgery, Izmir, Turkey
    Ann Plast Surg 53:560-4. 2004
    Peritendinous adhesions are the most important complication of flexor tendon injury. In this study, Seprafilm was used for the prevention of peritendinous adhesions following flexor tendon repair...
  25. ncbi Abdominal adhesions: intestinal obstruction, pain, and infertility
    W W Vrijland
    Department of Gynecology, Erasmus Medical Center, Dr Molewaterplein 40, 3015 CD Rotterdam, The Netherlands
    Surg Endosc 17:1017-22. 2003
    b>Adhesions cause bowel obstruction, chronic abdominal pain, and infertility. In this review, the incidence, clinical signs, diagnostic procedures, and treatment of these sequels of abdominal surgery are discussed...
  26. ncbi A randomized, controlled pilot study of the safety and efficacy of 4% icodextrin solution in the reduction of adhesions following laparoscopic gynaecological surgery
    G S diZerega
    University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Hum Reprod 17:1031-8. 2002
    Adhesion-related readmissions are frequent sequelae to gynaecological surgery. Attempts to prevent adhesions by separating healing peritoneal surfaces include site-specific barriers and hydroflotation by instilled solutions...
  27. ncbi Adhesion-related readmissions following gynaecological laparoscopy or laparotomy in Scotland: an epidemiological study of 24 046 patients
    A M Lower
    Isis Fertility Centre, Colchester CO4 9YA, UK
    Hum Reprod 19:1877-85. 2004
    ..This study evaluated the epidemiology of adhesion-related readmissions following open and laparoscopic procedures...
  28. ncbi Identification of adhesions on CT in small-bowel obstruction
    Bojan Petrovic
    Department of Radiology, Northwestern University Feinberg School of Medicine, Suite 800, 676 N Saint Clair Street, Chicago, IL 60611, USA
    Emerg Radiol 12:88-93; discussion 94-5. 2006
    Identification of adhesions on computed tomography (CT) in cases of small-bowel obstruction (SBO) is currently a diagnosis of exclusion...
  29. ncbi Reproductive outcome following treatment of intrauterine adhesions in Abuja, Nigeria
    E R Efetie
    Department of Obstetrics and Gynaecology National Hospital Abuja, Nigeria
    Niger J Clin Pract 9:164-8. 2006
    ..Both of these problems are sometimes traced to intrauterine adhesions (IUA) which is preventable in the majority of cases...
  30. ncbi Inhibition of chemokines prevents intraperitoneal adhesions in mice
    Murat Berkkanoglu
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Hum Reprod 20:3047-52. 2005
    ..The present study evaluates the efficacy of a broad-spectrum chemokine inhibitor, NR58-3.14.3, in the prevention of adhesion formation after i.p. surgery in mice...
  31. ncbi Anomalous vitreoretinal adhesions in patients with exudative age-related macular degeneration: an OCT study
    M Quaranta-El Maftouhi
    Centre Ophtalmologique Rabelais, Lyon, France
    Eur J Ophthalmol 16:134-7. 2006
    ..To analyze the relationship between the retina and the vitreous in patients with exudative age-related macular degeneration (ARMD)...
  32. ncbi Efficacy of bioactive polypeptides on bleeding and intra-abdominal adhesions
    Bobby Tingstedt
    Department of Surgery and Physical Chemistry 1, Centre of Chemistry, Lund University, Lund, Sweden
    Eur Surg Res 39:35-40. 2007
    Perioperative bleeding and postoperative adhesions are two problems encountered in abdominal surgery...
  33. ncbi Development of peritoneal adhesions in macrophage depleted mice
    Sandra H Burnett
    Department of Microbiology and Molecular Biology, Brigham Young University, Provo, Utah 84602, USA
    J Surg Res 131:296-301. 2006
    BACKGROUND: We present a new mouse model for the study of peritoneal adhesions using macrophage Fas-induced apoptosis (Mafia) transgenic mice expressing a Fas-FKBP construct under control of the murine c-fms promoter...
  34. ncbi Cyclooxygenase-2 is expressed in human fibroblasts isolated from intraperitoneal adhesions but not from normal peritoneal tissues
    Ghassan M Saed
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Detroit, Michigan 48201, USA
    Fertil Steril 79:1404-8. 2003
    ..To determine whether the COX-2 gene is expressed in human fibroblasts isolated from normal peritoneal and adhesion tissues...
  35. ncbi Use of transabdominal ultrasound to identify intraabdominal adhesions prior to laparoscopy: a prospective blinded study
    Shanu N Kothari
    Minimally Invasive Bariatric Surgery Clinic, Gundersen Lutheran Medical Center, La Crosse, WI, USA
    Am J Surg 192:843-7. 2006
    The aim of the current study was to assess the accuracy of transabdominal ultrasound (TAU) in identifying intra-abdominal adhesions (IAA) prior to laparoscopy in patients with previous abdominal surgery.
  36. ncbi Peritoneal effects of prosthetic meshes used to repair abdominal wall defects: monitoring adhesions by sequential laparoscopy
    Juan M Bellon
    Department of Surgery, Alcala University, Madrid, Spain
    J Laparoendosc Adv Surg Tech A 17:160-6. 2007
    ..This interface is often a site of complications such as intestinal obstruction or fistulas due to adhesions. The aim of this study was to follow the process of adhesion formation in several prosthetic materials by ..
  37. ncbi Differently charged polypeptides in the prevention of post-surgical peritoneal adhesions
    Laszlo Nehez
    Department of Surgery, Lund University Hospital, SE 221 85 Lund, Sweden
    Scand J Gastroenterol 42:519-23. 2007
    Peritoneal adhesions develop after almost all surgical interventions in the abdomen...
  38. ncbi Prevention of postoperative peritoneal adhesions: effects of lysozyme, polylysine and polyglutamate versus hyaluronic acid
    Laszlo Nehez
    Department of Surgery, Lund University, Sweden
    Scand J Gastroenterol 40:1118-23. 2005
    Intraperitoneal adhesions are an important cause of postoperative intestinal obstruction, abdominal discomfort and infertility...
  39. ncbi Seprafilm (modified hyaluronic acid and carboxymethylcellulose) acts as a physical barrier
    L April Gago
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Fertil Steril 80:612-6. 2003
    ..To characterize the molecular changes that occur in normal fibroblasts, adhesion fibroblasts, and mesothelial cells as a result of exposure to modified hyaluronic acid and carboxymethylcellulose (Seprafilm)...
  40. ncbi Intra-uterine adhesions and fertility outcome: how to optimize success?
    Pinar H Kodaman
    Yale University School of Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Section of Reproductive Endocrinology and Infertility, New Haven, Connecticut 06520, USA
    Curr Opin Obstet Gynecol 19:207-14. 2007
    To review the etiology, diagnosis, and clinical manifestations of intra-uterine adhesions and to address treatment with a specific focus on fertility outcome.
  41. ncbi Medicolegal consequences of adhesions
    Harold Ellis
    Division of Anatomy, Guy s, King s and St Thomas School of Biomedical Science, London SE1 1UL
    Hosp Med 65:348-50. 2004
    Postoperative intra-abdominal adhesions are an almost invariable consequence of abdominal and pelvic surgery...
  42. ncbi RNA interference targeting hypoxia inducible factor 1alpha reduces post-operative adhesions in rats
    Tatiana Segura
    Ecole Polytechnique Federale de Lausanne EPFL, Institute of Bioengineering and Institute of Chemical Sciences and Engineering, Lausanne, Switzerland
    J Surg Res 141:162-70. 2007
    ..To investigate the use of RNA interference mediated gene down-regulation targeting hypoxia inducible factor 1alpha (HIF-1alpha) and plasminogen activator inhibitor 1 (PAI-1) in an effort to prevent abdominal adhesion formation...
  43. ncbi Pain mapping of adhesions
    Larry Demco
    University of Calgary, Calgary, Alberta, Canada
    J Am Assoc Gynecol Laparosc 11:181-3. 2004
    To determine the nature and location of adhesions and their relationship to abdominal pain in patients undergoing awake microlaparoscopy.
  44. ncbi Transplantation of an autologous mesothelial cell sheet prepared from tunica vaginalis prevents post-operative adhesions in a canine model
    Touko Asano
    Department of Urology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Tissue Eng 12:2629-37. 2006
    Post-operative adhesions often cause severe complications such as bowel obstruction and abdominopelvic pain. Previously, we reported that transplantation of a mesothelial cell sheet is effective for preventing adhesion in rat model...
  45. ncbi Adhesions and colorectal surgery - call for action
    M C Parker
    Darent Valley Hospital, Dartford, Kent, UK
    Colorectal Dis 9:66-72. 2007
    Mounting evidence highlights that adhesions are now the most frequent complication of abdominopelvic surgery, yet many surgeons are still not aware of the extent of the problem and its serious consequences...
  46. ncbi Intraperitoneal administration of adenosine inhibits formation of abdominal adhesions
    Edwin K Jackson
    Center for Clinical Pharmacology, Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Dis Colon Rectum 47:1390-6. 2004
    ..fibroblast proliferation and collagen production and inflammation and enhances angiogenesis, we tested the hypothesis that adenosine applied into the abdominal cavity safely and effectively reduces formation of abdominal adhesions.
  47. ncbi Paclitaxel-loaded crosslinked hyaluronic acid films for the prevention of postsurgical adhesions
    John K Jackson
    Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada
    Pharm Res 19:411-7. 2002
    ....
  48. ncbi Omentum prevents intestinal adhesions to mesh graft in abdominal infections and serosal defects
    B Karabulut
    Department of Pediatric Surgery, Gazi University, Faculty of Medicine, Ankara, Turkey
    Surg Endosc 20:978-82. 2006
    ..In this study, the effects resulting from the presence or absence of the omentum were evaluated in the setting of infection or serosal defects in the formation of adhesions in abdominal closures using mesh grafts.
  49. ncbi Human peritoneal adhesions show evidence of tissue remodeling and markers of angiogenesis
    Jonathan C Epstein
    Faculty of Life Sciences, The University of Manchester, and Department of Surgery, Christie Hospital, Manchester, M13 9PT, United Kingdom
    Dis Colon Rectum 49:1885-92. 2006
    This study was designed to investigate the vascular structure and angiogenic activity of human peritoneal adhesions.
  50. ncbi Amnion graft following hysteroscopic lysis of intrauterine adhesions
    Mohamed I Amer
    Department of Obstetrics and Gynecology, Ain Shams University, Cairo, Egypt
    J Obstet Gynaecol Res 32:559-66. 2006
    To evaluate the safety and efficacy of amnion grafting after hysteroscopic lysis of intrauterine adhesions.
  51. ncbi Collagen foil (TissuFoil E) reduces the formation of adhesions when using polypropylene mesh for the repair of experimental abdominal wall defects
    Frank Schönleben
    Chirurgische Klinik mit Poliklinik der Universität Erlangen Nürnberg, Krankenhausstr 12, 91054 Erlangen, Germany
    Int J Colorectal Dis 21:840-6. 2006
    ..Severe adhesions are a common cause of intestinal obstruction, or even intestinal fistulas...
  52. ncbi Transvaginal three-dimensional ultrasonography combined with serum CA 125 level for the diagnosis of pelvic adhesions before laparoscopic surgery
    Kok Min Seow
    Department of Obstetrics and Gynecology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    J Am Assoc Gynecol Laparosc 10:320-6. 2003
    To investigate the role of transvaginal three-dimensional ultrasonography combined with serum CA 125 level in diagnosing pelvic adhesions before scheduled laparoscopic surgery.
  53. ncbi Interosseous-lumbrical adhesions of the hand: contribution of magnetic resonance imaging to diagnosis and treatment planning
    Virak Tan
    Division of Hand and Microsurgery, University of Medicine and Dentistry of New Jersey NJ Medical School, 90 Bergen Street, DOC Suite 5200, Newark, NJ 07103, USA
    J Hand Surg Am 27:639-43. 2002
    ..have not found magnetic resonance imaging (MRI) to be helpful in the diagnosis of interosseous-lumbrical tendon adhesions of the hand...
  54. ncbi Peritoneal adhesions: pathogenesis, assessment and effects
    M P Senthilkumar
    Department of Surgery, Dumfries and Galloway Royal Infirmary, Dumfries, UK
    Trop Gastroenterol 27:11-8. 2006
    As modem surgery has evolved, there has been an increase in iatrogenic peritoneal adhesions. Most surgeons manage adhesions and their related complications on a regular basis...
  55. ncbi Reduction of postoperative adhesions by N,O-carboxymethylchitosan and spermine NONOate in rats
    Bulent Duran
    Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey
    Exp Anim 52:267-72. 2003
    Postsurgical adhesions can occur following virtually all types of surgery, resulting in serious clinical complications. Therefore, prevention of adhesions is an important goal of surgical practice...
  56. ncbi The effect of Seprafilm on adhesions in strabismus surgery-an experimental study
    Seyhan B Ozkan
    Department of Ophthalmology, Adnan Menderes University Medical School, Aydm, Turkey
    J AAPOS 8:46-9. 2004
    ..b>Adhesions occurring after strabismus surgery may affect surgical outcome...
  57. ncbi Expression of transforming growth factor-beta and extracellular matrix by human peritoneal mesothelial cells and by fibroblasts from normal peritoneum and adhesions: effect of Tisseel
    Ghassan M Saed
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University Detroit Medical Center, Hutzel Hospital, 4707 St Antoine Boulevard, Detroit, MI 48201, USA
    Wound Repair Regen 12:557-64. 2004
    We have previously shown that fibroblasts obtained from adhesions produce greater amounts of transforming growth factor-beta 1 (TGF-beta1) and extracellular matrix (ECM) molecules than normal fibroblasts isolated from normal peritoneum...
  58. ncbi The prevalence of interstitial cystitis, endometriosis, adhesions, and vulvar pain in women with chronic pelvic pain
    Edward J Stanford
    Department of Urogynecology Obstetrics and Gynecology, St Mary s Good Samaritan Hospital, Centralia, Illinois 62801, USA
    J Minim Invasive Gynecol 12:43-9. 2005
    ..To estimate the prevalence of bladder-origin pain, intraperitoneal pathology, and vulvar pain in patients undergoing laparoscopy for chronic pelvic pain (CPP)...
  59. ncbi Reduction of adhesions with composite AlloDerm/polypropylene mesh implants for abdominal wall reconstruction
    Charles E Butler
    Department of Plastic Surgery, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Plast Reconstr Surg 114:464-73. 2004
    ..includes the use of structural prosthetic materials, such as polypropylene mesh, that can induce dense abdominal adhesions to peritoneal structures. AlloDerm (LifeCell Corp., Branchburg, N.J...
  60. ncbi Use of a high-molecular-weight carboxymethylcellulose in a tissue protective solution for prevention of postoperative abdominal adhesions in ponies
    David J Murphy
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610, USA
    Am J Vet Res 63:1448-54. 2002
    To evaluate efficacy and safety of IP administration of high-molecular-weight carboxymethylcellulose (HMW CMC) for the prevention of postoperative intra-abdominal adhesions in ponies.
  61. ncbi Peritoneal fluid concentrations of matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and transforming growth factor-beta in women with pelvic adhesions
    Ying C Cheong
    Department of Obstetrics and Gynaecology, St Mary s Hospital, Milton Road, Portsmouth, Hampshire, United Kingdom
    Fertil Steril 79:1168-75. 2003
    ..tissue inhibitor of metalloproteinase-1 (TIMP-1), and transforming growth factor-beta (TGF-beta) is influenced by the presence or absence of adhesions, and whether the concentration of these mediators vary throughout the menstrual cycle.
  62. ncbi Clinical evaluation of a viscoelastic gel for reduction of adhesions following gynaecological surgery by laparoscopy in Europe
    P Lundorff
    Department of Obstetrics and Gynecology, Viborg Hospital, Viborg, Denmark
    Hum Reprod 20:514-20. 2005
    ..Commonly used adhesion prevention devices either cannot be applied or are difficult to use via laparoscopy. A viscoelastic gel was developed specifically for adhesion prophylaxis during minimally invasive surgery...
  63. ncbi Adhesion formation after laparoscopic excision of endometriosis and lysis of adhesions
    Jason D Parker
    National Institutes of Health, Bethesda, MD, USA
    Fertil Steril 84:1457-61. 2005
    ..To evaluate adhesion reformation after laparoscopic excision of endometriosis and adhesiolysis in women with chronic pelvic pain...
  64. ncbi Role of fibrin glue in the prevention of peritoneal adhesions in ventral hernia repair
    Juan Antonio Martín-Cartes
    Surgical Department, Laparoscopic Surgery Unit, Virgen del Rocio University Hospital, c Baños 76, 41002, Seville, Spain
    Surg Today 38:135-40. 2008
    ..The aim of this study was to investigate the effects of fibrin glue on the prevention of postoperative peritoneal adhesion to prosthetic materials used in ventral hernia repair...
  65. ncbi Apoptosis and proliferation of human peritoneal fibroblasts in response to hypoxia
    Ghassan M Saed
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, and the C S Mott Center for Human Growth and Development, Wayne State University, Detroit, Michigan 48201, USA
    Fertil Steril 78:137-43. 2002
    To determine the effect of hypoxia on apoptosis and proliferation of fibroblasts cultured from normal peritoneum or adhesions.
  66. ncbi Comparison of two laparoscopic treatments for experimentally induced abdominal adhesions in pony foals
    Jennifer L Lansdowne
    Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Canada
    Am J Vet Res 65:681-6. 2004
    To compare laparoscopic dissection with-laparoscopic dissection combined with abdominal instillation of ferric hyaluronate gel for the treatment of experimentally induced adhesions in pony foals.
  67. ncbi Female infertility and free radicals: potential role in adhesions and endometriosis
    Zeynep Alpay
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, C S Mott Center for Human Growth and Development, Wayne State University, Detroit, Michigan 48201, USA
    J Soc Gynecol Investig 13:390-8. 2006
    ..Peritoneal adhesions and endometriosis are relatively commonly identified in women, and are known to be associated with infertility ..
  68. ncbi Special techniques in pain management: lysis of adhesions
    Carlos O Viesca
    Texas Tech University Health Sciences Center, 3601 4th Street, Room 1C 282, Lubbock, TX 79430, USA
    Anesthesiol Clin North America 21:745-66, vi. 2003
    ..To enhance treatment outcome, an understanding of the pathophysiology of the underlying pain and the design of target-specific treatment modalities is important...
  69. ncbi Prevention of gynaecological adhesions using haemostatic fleece in a rabbit model
    G Dickneite
    ZLB Behring GmbH, Marburg, Germany
    J Int Med Res 34:505-13. 2006
    ..After 14 days, the animals were killed and examined for the presence of adhesion. The lengths of any adhesions were measured and the severity was recorded as a score (0, no adhesion; 1, adhesion easy to lyse; 2, adhesion ..
  70. ncbi Complications and feasibility of laparoscopic adhesiolysis in patients with chronic abdominal pain. A retrospective study
    D J Swank
    Department of Surgery, Groene Hart Hospital, Gouda, PO Box 1098, 2800 BB Gouda, The Netherlands
    Surg Endosc 16:1468-73. 2002
    ..A retrospective study was done to determine whether laparoscopic adhesiolysis benefits patients with chronic abdominal pain. Factors that influence complications and feasibility of laparoscopic adhesiolysis were evaluated...
  71. ncbi Evaluation of laparoscopic adhesiolysis for the treatment of experimentally induced adhesions in pony foals
    Ludovic P Boure
    Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Canada
    Am J Vet Res 63:289-94. 2002
    To assess the efficacy of laparoscopic adhesiolysis in the treatment of experimentally induced adhesions in foals.
  72. ncbi Complete hypopharyngeal obstruction by mucosal adhesions: a complication of intensive chemoradiation for advanced head and neck cancer
    Elizabeth J Franzmann
    Department of Otolaryngology, University of Miami Sylvester Comprehensive Cancer Center, 1475 NW 12th Avenue, Suite 4037, Miami, FL 33136, USA
    Head Neck 28:663-70. 2006
    ..seen with complete obstruction of the hypopharynx distal to the site of the primary cancer, and in whom we postulate that the obstruction was caused by separable mucosal adhesions rather than obliteration by a mature fibrous stricture.
  73. ncbi Bowel injury as a complication of laparoscopy
    M van der Voort
    Department of Surgery, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Br J Surg 91:1253-8. 2004
    ..Bowel injury is a rare but serious complication of laparoscopic surgery. This review examines the incidence, location, time of diagnosis, causative instruments, management and mortality of laparoscopy-induced bowel injury...
  74. ncbi Two experimental models for generating abdominal adhesions
    Wolfgang B Gaertner
    Department of Surgery, University of Minnesota, 420 Delaware St SE, MMC 195, Minneapolis, MN 55455, USA
    J Surg Res 146:241-5. 2008
    To develop dependable rat models for generating abdominal adhesions that allow for objective evaluation and quantification.
  75. ncbi Adhesions caused by umbilical piercing
    Gary Ventolini
    Department of Obstetrics and Gynecology, Good Samaritan Hospital, Cincinnati, OH, USA
    J Am Assoc Gynecol Laparosc 10:281. 2003
    ..Diagnostic laparoscopy revealed an umbilical adhesion from the small bowel to the anterior abdominal wall. The patient removed the umbilical piercing but declined surgery for adhesiolysis...
  76. ncbi The preventive effect of Rofecoxib in postoperative intraperitoneal adhesions
    M Aldemir
    Department of General Surgery, Dicle University, Faculty of Medicine, Diyarbakir, Turkey
    Acta Chir Belg 104:97-100. 2004
    ..Therefore, we planned this study to experimentally evaluate the effects of Rofecoxib, the selective cyclo-oxygenase-2 inhibitor, in postoperative intraperitoneal adhesions in an animal model.
  77. ncbi Intraobserver and interobserver reliability of videotaped laparoscopy evaluations for endometriosis and adhesions
    Philomeen T M Weijenborg
    Department of Gynecology, Leiden University Medical Center, Leiden, The Netherlands
    Fertil Steril 87:373-80. 2007
    ..To determine the intra- and interobserver reliability of evaluations during videotaped laparoscopy, with real-time laparoscopy as the "gold standard."..
  78. ncbi Preoperative ultrasound to predict infraumbilical adhesions: a study of diagnostic accuracy
    Frank F Tu
    Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Am J Obstet Gynecol 192:74-9. 2005
    The purpose of this study was to determine the test characteristics of preoperative abdominal ultrasound in predicting infraumbilical adhesions in women.
  79. ncbi Long-term follow-up and cost analysis following surgery for small bowel obstruction caused by intra-abdominal adhesions
    B Tingstedt
    Department of Surgery, Lund University, Lund, Sweden
    Br J Surg 94:743-8. 2007
    This study examined the natural course of patients following surgery for small bowel obstruction (SBO) caused by abdominal adhesions. In addition, a cost analysis was performed.
  80. ncbi Effectiveness of treatment to prevent adhesions after abdominal surgery: an experimental evaluation in rats
    Cem Kaan Parsak
    Department of General Surgery, Cukurova University, School of Medicine, Adana, Turkey
    Adv Ther 24:796-802. 2007
    ..Ileal content was the leading cause of intraperitoneal adhesions in the first phase; in the second phase, in group 1, 2 mL ileal content and 5 mL povidone-iodine (10%) were used;..
  81. ncbi The effects of a combination of hyaluronic and amniotic membrane on the formation of peritendinous adhesions after flexor tendon surgery in chickens
    G Y Ozgenel
    Department of Plastic and Reconstructive Surgery, Division of Hand Surgery, Uludag University Medical School, Bursa, Turkey
    J Bone Joint Surg Br 86:301-7. 2004
    ..the effects of the intra-operative application of a combination of hyaluronic acid and amniotic membrane on adhesions in the flexor tendons of a chicken model...
  82. ncbi Camptothecin-loaded films for the prevention of postsurgical adhesions
    J Cashman
    ARC Pharmaceuticals Inc, University of British Columbia, 102 2386 East Mall, Vancouver BC, Canada
    Inflamm Res 53:355-62. 2004
    ..The purpose of this work was to investigate the local application of camptothecin (CPT), a drug with anti-inflammatory, antiproliferative and antiangiogenic properties, as an inhibitor of surgical adhesion formation in rats...
  83. ncbi Expression of connective tissue growth factor in intra-abdominal adhesions
    Klaus Thaler
    Department of Colorectal Surgery, Cleveland Clinic Florida, 2950 Cleveland Clinic Boulevard, Weston, FL 33331, USA
    Dis Colon Rectum 45:1510-9. 2002
    ..The aim of our study was to determine the expression pattern of connective tissue growth factor in postoperative intra-abdominal adhesions.
  84. ncbi Mast cells facilitate local VEGF release as an early event in the pathogenesis of postoperative peritoneal adhesions
    Ronan A Cahill
    Department of Academic Surgery, Cork University Hospital, Ireland
    Surgery 140:108-12. 2006
    ..Peritoneal mast cells are likely to initiate this process, whereas vascular permeability/endothelial growth factor (VEGF) may facilitate the degree to which subsequent adhesion formation occurs...
  85. ncbi Can arthrocentesis release intracapsular adhesions? Arthroscopic findings before and after irrigation under sufficient hydraulic pressure
    Shinya Yura
    Oral and Maxillofacial Surgery, Tonami General Hospital, 1 6 Shintomi cho, Tonami City, Toyama ken 939 1395, Japan
    J Oral Maxillofac Surg 61:1253-6. 2003
    To investigate the effect of release of intra-articular adhesions of arthrocentesis, we examined patients with closed lock of the temporomandibular joint by arthroscopy before and after irrigation.
  86. pmc Role of laparoscopy in identifying the clinical significance and cause of adhesions and chronic pelvic pain: a retrospective review at the Kiel School of Gynecological Endoscopy
    Liselotte Mettler
    Kiel School of Gynecological Endoscopy, Department of Obstetrics and Gynecology, University Hospitals Schleswig Holstein, Campus Kiel, Michaelisstrasse 16, Kiel 24105, Germany
    JSLS 11:303-8. 2007
    We sought to define the role of laparoscopy in identifying the clinical significance, cause, and association between adhesions and chronic pelvic pain.
  87. ncbi Impact of adhesions in colorectal surgery
    R Bhardwaj
    Department of Surgery, Darent Valley Hospital, Kent, UK
    Colorectal Dis 9:45-53. 2007
    The extent of the problem of adhesions is considerable and poses a significant burden on healthcare systems, the workload of surgeons and the lives of patients...
  88. ncbi Effectiveness of auto-cross-linked hyaluronic acid gel in the prevention of intrauterine adhesions after hysteroscopic adhesiolysis: a prospective, randomized, controlled study
    Giuseppe Acunzo
    Department of Obstetrics and Gynaecology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Hum Reprod 18:1918-21. 2003
    A prospective, randomized, controlled study was performed to assess the efficacy of auto-cross-linked hyaluronic acid (ACP) gel in preventing the development of intrauterine adhesions following hysteroscopic adhesiolysis.
  89. ncbi Temporary ovarian suspension at laparoscopy for prevention of adhesions
    Mostafa I Abuzeid
    Division of Reproductive Endocrinology, Hurley Medical Center, Two Hurley Plaza, Suite 101, Flint, MI 48503, USA
    J Am Assoc Gynecol Laparosc 9:98-102. 2002
    ..In four patients (80%), we found no evidence of recurrent adhesions. The remaining 20% had minimal adhesions...
  90. ncbi The incidence and morbidity of adhesions after treatment of neonates with gastroschisis and omphalocele: a 30-year review
    Floortje C van Eijck
    Department of General Surgery, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Pediatr Surg 43:479-83. 2008
    ..Knowledge of its incidence and potential risk factors in a well-documented group with strict follow-up is needed to guide preventive measures...
  91. ncbi Ovarian endometrioma: postoperative adhesions following bipolar coagulation and suture
    M Pellicano
    Department of Obstetrics and Gynecology, University of Naples Federico II, Naples, Italy
    Fertil Steril 89:796-9. 2008
    To compare bipolar coagulation and suturing of the ovary in terms of postoperative ovarian adhesions after laparoscopic ovarian cystectomy for endometriosis.
  92. ncbi The effect of resveratrol on surgery-induced peritoneal adhesions in an experimental model
    Gokhan Sogutlu
    General Surgery Department, Inonu University Medical School, Malatya, Turkey
    Cell Biochem Funct 25:217-20. 2007
    ..001, respectively). Introduction of resveratrol into the peritoneal cavity at the time of surgery reduced adhesion formation effectively in this model. Resveratrol probably acts through reduction of lipid peroxidation products...
  93. ncbi Endometrial thickness measured by ultrasound scan in women with uterine outlet obstruction due to intrauterine or upper cervical adhesions
    Sin Ting Lo
    Department of Obstetrics and Gynaecology, Queen Elizabeth II Research Institute for Mothers and Infants, University of Sydney, NSW 2006 Australia
    Hum Reprod 23:306-9. 2008
    A subgroup of women with Asherman's syndrome has adhesions of limited extent completely blocking the lower uterine cavity or upper cervix, whereas the upper endometrium remains normal. Haematometra are rarely found in these women...
  94. ncbi Reduction of postoperative perineural adhesions by Hyaloglide gel: an experimental study in the rat sciatic nerve
    Phong Dam-Hieu
    Experimental Neurosurgery Laboratory, Centre Hospitalier Universitaire de Bicetre, Faculte de Medecine Paris Sud, Le Kremlin Bicetre, France
    Neurosurgery 56:425-33; discussion 425-33. 2005
    ..To assess the effects of Hyaloglide gel (or auto-cross-linked polysaccharide [ACP] gel; Fidia Advanced Biopolymers, Abano Terme, Italy), a hyaluronan-derivative polymer, on peripheral nerve scarring and nerve regeneration...
  95. ncbi Effect of oral D-penicillamine vs. colchicine on experimentally induced peritoneal adhesions in rats
    Saman Nikeghbalian
    Shiraz Organ Transplantation Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
    Fertil Steril 88:1187-9. 2007
    ..To evaluate the effects of d-penicillamine on prevention or reduction of adhesion band formation and to compare its effects with those of colchicine in an animal model...
  96. ncbi The effect of immunosuppression on peritoneal adhesions formation after small bowel transplantation in rats
    Nir Wasserberg
    Department of Surgery, University of Miami School of Medicine, Miami, Florida, USA
    J Surg Res 141:294-8. 2007
    ..The purpose of the study was to investigate the influence of immunosuppression on peritoneal adhesion formation after intestinal transplantation in rats...
  97. pmc The role of laparoscopic adhesiolysis in the treatment of patients with chronic abdominal pain or recurrent bowel obstruction
    Vafa Shayani
    Department of Surgery, Loyola University Medical Center, Maywood, IL 60153, USA
    JSLS 6:111-4. 2002
    ..Laparoscopic adhesiolysis may provide relief of symptoms in patients with prior abdominal surgery with chronic abdominal pain or recurrent bowel obstruction...
  98. pmc Polymers in the prevention of peritoneal adhesions
    Yoon Yeo
    School of Pharmacy and Pharmaceutical Sciences, Weldon School of Biomedical Engineering, Purdue University, West Lafayelte IN, USA
    Eur J Pharm Biopharm 68:57-66. 2008
    Peritoneal adhesions are serious complications of surgery, and can result in pain, infertility, and potentially lethal bowel obstruction...
  99. ncbi Prevention of postoperative abdominal adhesions by a novel, glycerol/sodium hyaluronate/carboxymethylcellulose-based bioresorbable membrane: a prospective, randomized, evaluator-blinded multicenter study
    Zane Cohen
    Department of Surgery, Mount Sinai Hospital, University of Toronto, Toronto, Canada
    Dis Colon Rectum 48:1130-9. 2005
    Postoperative abdominal adhesions are associated with significant morbidity and mortality, placing a substantial burden on healthcare systems worldwide...
  100. ncbi Micronized purified flavonoid fraction may prevent formation of intraperitoneal adhesions in rats
    Hatice Gulsen Yilmaz
    Department of General Surgery, Faculty of Medicine, University of Dicle, Diyarbakir, Turkey
    Fertil Steril 84:1083-8. 2005
    To evaluate the efficacy of an anti-inflammatory and capillary regulator drug, micronized purified flavonoid fraction (MPFF), in the prevention of postoperative formation of adhesions.
  101. ncbi Crosslinked hyaluronan hydrogels containing mitomycin C reduce postoperative abdominal adhesions
    Yanchun Liu
    Department of Medicinal Chemistry, The University of Utah, 419 Wakara Way, Salt Lake City, UT 84108, USA
    Fertil Steril 83:1275-83. 2005
    To evaluate the efficacy of crosslinked hyaluronan (HA) hydrogels that contained covalently-bound mitomycin C (MMC) in reducing postoperative adhesions in a rat uterine horn model.

Research Grants74

  1. Laser-Activated Collagen Adhesives for Herniorrhaphy
    Barbara Soltz; Fiscal Year: 2006
    ..In fact, adhesions represent a significant source of morbidity and mortality and are a common cause of small bowel obstruction in ..
  2. Pathogen-host Interactions that Remodel the Cytoskeleton
    Tina Izard; Fiscal Year: 2010
    ..actin cytoskeleton by binding to other key partners such as talin, which binds to integrin receptors in focal adhesions, or to a- actinin, which plays key roles in adherens junctions...
  3. Nuclear-Cytoplasmic Shuttling of Foxc2 via 14-3-3 Determines Proximal Tubule Cell
    DIANA LYNNE GOLDEN; Fiscal Year: 2012
    ..seen following ischemic tubular injury promotes [unreadable]-actinin stabilization and/or localization to focal adhesions, where it is critical for FA turnover and cell morphogenesis/migration...
  4. Growth Hormone Regulation of SH2B1
    Christin Carter-Su; Fiscal Year: 2013
    ..g., focal adhesions, lamellipodia, cytoplasm, nucleus)...
  5. Genetic Analysis of FAK Activity
    David D Schlaepfer; Fiscal Year: 2012
    ..Signals generated by integrins at cell attachment sites termed focal adhesions are mediated by the recruitment of cytoskeletal and signaling proteins in a manner that remain under ..
  6. Regulation of Fibronectin Matrix Assembly by uPAR
    PAULA J MC KEOWN-LONGO; Fiscal Year: 2012
    ..whether uPAR-mediated EGFR transactivation reroutes the trafficking of EGFR from lysosomes and into focal adhesions where it forms complexes with the 1521 integrin...
  7. Ibuprofen and enteric neural crest precursor migration
    ELLEN MERRICK; Fiscal Year: 2013
    ..These investigations will allow for in depth analysis of ENCC actin protrusions and the dynamics of focal adhesions. In addition, ENCCs from transgenic animals with null mutations in Cox1 and Cox2, enzymes inhibited by ibuprofen,..
  8. The Role of Leptin in Liver Fibrogenesis
    Frank A Anania; Fiscal Year: 2012
    ..of hepatic fibrosis by inhibiting activation of focal adhesion kinase (FAK), preventing formation of focal adhesions (FA) which results in the suppression of key fibrogenic properties of the activated HSC...
  9. Structure and function of stress fibers and cell adhesion sites
    Mary C Beckerle; Fiscal Year: 2013
    ..of catastrophic stress fiber breaks and restores the capacity of stress fibers to transmit force via the focal adhesions to the underlying substrate...
  10. Role of the Tail Domain in Vinculin Function
    Sharon L Campbell; Fiscal Year: 2010
    ..applicant): This proposal is focused on vinculin, a cytoskeletal protein that is a prominent component of focal adhesions and adherens junctions...
  11. Multiple Molecular Mechanisms for Adiponectin Therapy in Hepatic Fibrogenesis
    Frank A Anania; Fiscal Year: 2013
    ..of hepatic fibrosis by inhibiting activation of focal adhesion kinase (FAK), preventing formation of focal adhesions (FAs), which results in the suppression of key fibrogenic properties of the activated HSC...
  12. Role of Focal Adhesion Kinase (FAK) in Nephrosis and Nephritis
    Shuta Ishibe; Fiscal Year: 2013
    ..contacts between the glomerular basement membrane and the extracellular matrix, which is comprised of focal adhesions and integrins...
  13. Novel anti-toxin compounds against Yersinia infections
    Maurizio Pellecchia; Fiscal Year: 2010
    ..type III sectretion system, YopH is a highly active bacterial PTPase that is results in disruption of focal adhesions, and inhibition of integrin-mediated bacterial phagocytosis, both of which are highly dependent on tyrosine ..
  14. Role of Nox4 in VSMC Migration
    MAZEN KHALIL KHALIL; Fiscal Year: 2011
    ..This results in actin polymerization and formation of focal adhesions (FA). The cell uses the FA as a strut against which it contracts and moves...
  15. Signaling Connections Controlling Cell Motility and Invasion
    David D Schlaepfer; Fiscal Year: 2013
    ..is a highly regulated process that involves the formation and turnover of cell-matrix contact sites termed focal adhesions, sites of matrix-integrin attachment, tension generation, and cell survival signals...
  16. Smooth muscle adhesion and plasticity in coronary and outflow tract development
    Joan M Taylor; Fiscal Year: 2013
    ..We also made the interesting and potentially important discovery that leupaxin shuttles between focal adhesions and the nucleus and that this process was regulated by FAK signaling...
  17. Mechanism and role of DLC-1 tumor suppressor loss in lung cancer
    Channing J Der; Fiscal Year: 2012
    ..DLC-1 is associated with focal adhesions (FAs) and this association is critical for DLC-1 tumor suppression but surprisingly, not for Rho GTPase ..
  18. Stress: Potential Impact on an Animal Model of Endometriosis
    Caroline B Appleyard; Fiscal Year: 2012
    ..This condition is characterized by peritoneal inflammation, fibrosis, adhesions and ovarian cysts, which result in chronic pelvic pain, pain during intercourse (dyspareunia), painful periods (..
  19. Endoplasmic reticulum structure and dynamics in breast cancer cell metastasis and
    JASON EDWARD LEE; Fiscal Year: 2013
    ..recent studies have reported that integrin-[unreadable]3 and protein phosphatase 1B (PTP1B) trafficking to focal adhesions was dependent on ER tubule extension along microtubules...
  20. ABNORMAL BIGH3 AGGREGATIONS IN CORNEAL DYSTROPHIES
    Andrew J W Huang; Fiscal Year: 2011
    ..These dystrophies are found to have abnormal stromal deposits and related poor epithelial adhesions with resultant painful corneal erosions. Corneal transplantation is often needed to restore corneal clarity...
  21. Spatiotemporal Regulation of Membrane Raft Trafficking in Virus Activated Cells
    Tione Buranda; Fiscal Year: 2012
    ..that the initial binding of SNV to DAF is followed by Rac1 stimulated actin remodeling, disassembly of focal adhesions, and leads to loss of cell-cell contact and cell-substrate adhesion...
  22. OUTER MEMBRANE PROTEINS OF PATHOGENIC LEPTOSPIRA SPECIES
    David A Haake; Fiscal Year: 2013
    ..of these aims, we will examine the molecular mechanisms by which OMPs are regulated, identify additional OMP adhesions and examine their roles in pathogenesis and immunity, and develop E...
  23. Identification of Mechanically Sensitive Proteins in Early Development
    Douglas W DeSimone; Fiscal Year: 2013
    ..will also be developed that will enable simultaneous application of force to both cadherin and integrin adhesions in order to mimic tissue-level stresses in single cells...
  24. The Role of HEF1 in Ovarian Cancer Development, Progression, and Metastasis
    Denise C Connolly; Fiscal Year: 2013
    HEF1/NEDD9/Cas-L (HEF1) is a molecular scaffolding protein that mediates cellular signaling from focal adhesions during interphase and at centrosomes during mitosis...
  25. Mechanically Stressed VSMC: A Role for Slingshot Phosphatase in Inflammation
    Alejandra San Martin; Fiscal Year: 2013
    ..One main source of ROS in the vasculature is Nox4, which is found in focal adhesions (FAs), the sites of engagement of the cell to the extracellular substrate...
  26. Quantitative Analysis of Chemotactic Motility Cycle of Ameboid Cells
    JUAN CARLOS LASHERAS; Fiscal Year: 2013
    ..of actin-directed motors, F-actin regulation, actin crosslinking, motor protein-mediated contractility, and cell adhesions. However, precise knowledge of the biophysical coordination of these processes has been limited by the lack of ..
  27. Microtubule-associated Rac
    Anna Birukova; Fiscal Year: 2013
    ..In contrast, effects of barrier-protective agents on crosstalk between MT, cell adhesions, and actin cytoskeleton are not clear, nor the role of MT changes in Rac regulation is described...
  28. Mechanisms of glomerular disesase progression
    Jeffrey R Schelling; Fiscal Year: 2012
    ..unreadable]8-dependent cell adhesion - the first demonstration of any [unreadable]8 ligand supporting stable adhesions. We have shown that [unreadable]8 interacts with Rho GDI...
  29. Macrophage Infiltration of Renal Tissue via beta-3 Integrins and Agrin
    Scott D Blystone; Fiscal Year: 2013
    ..We will characterize the production of macrophage podosomal adhesions and pseudopods that are required for migration into three-dimensional tissues by TIRF microscopy of living ..
  30. Molecular Function of Palladin's Ig Domains in Cell Adhesion and Motility
    Carol A Otey; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Both cell-cell and cell-matrix adhesions require the participation of the actin cytoskeleton...
  31. Regulation of Axon Guidance by Second Messengers
    Timothy M Gomez; Fiscal Year: 2013
    ..is focused on understanding how axon guidance cues regulate axon outgrowth by modulating integrin-dependent adhesions. As a number of cognitive disorders result from improper axon pathfinding, understanding the molecular basis for ..
  32. NoxR1, a regulator of Nox4-dependent cytoskeletal remodeling in vascular cells
    Kathy K Griendling; Fiscal Year: 2010
    ..that NoxR1 overexpression in VSMCs causes a significant increase in NADPH oxidase activity, an increase in focal adhesions, and an increase stress fiber formation, while knockdown of NoxR1 induces a profound alteration of the ..
  33. Anti-angiogenic activity of neurokinin B
    Soumen Paul; Fiscal Year: 2010
    ..of focal adhesion kinase, paxillin, p130Cas, spatial and temporal association of these molecules to form focal adhesions, and activation of Rho family of GTPases Rac1 and CDC42...
  34. Directing Stem Cell Differentiation on Biologically Inspired Micropatterned Surfa
    Anita Shukla; Fiscal Year: 2012
    ..It is hypothesized that hMSCs that are restricted to making focal adhesions directly mimicking the adhesions of fully differentiated cells will preferentially differentiate to these ..
  35. Deleted in liver cancer 1 (DLC1) in liver development and disease
    Yi Ping Shih; Fiscal Year: 2013
    ..DLC1 regulates cell migration through modulation of the actin cytoskeleton and focal adhesions. Multiple studies have demonstrated that the RhoGAP domain is necessary for the tumor suppressive function of ..
  36. Role of Surface Roughness in Regulating Tumor Cell Behavior
    Sarah C Glover; Fiscal Year: 2012
    ..less and more tumorigenic cells cultured on a "peak-like" matrix actually had higher Rho activity and more focal adhesions as revealed by talin staining...
  37. Vascular Oxidases in Migration
    Kathy K Griendling; Fiscal Year: 2013
    ..accompanies lamellipodial protrusion, while the production of H2O2 by integrin-mediated Nox4 activation in focal adhesions regulates focal adhesion turnover and stabilizes actin filaments via oxidation...
  38. The effects of stress on the pathophysiology of endometriosis
    MARIELLY CUEVAS; Fiscal Year: 2010
    ..This condition is characterized by peritoneal inflammation, fibrosis, adhesions and ovarian cysts, which result in chronic pelvic pain, pain during intercourse (dyspareunia), painful periods (..
  39. Integrin Targeted Therapy for the Treatment of Ovarian Cancer
    FRANK CALZONE; Fiscal Year: 2013
    ..and polyethylene oxide (PEO) gel approved for human use in Europe and Australia for prevention of post-surgical adhesions. This approach combines the benefits of high-concentration local peritoneal treatment as well as sustained drug ..
  40. Cell Adhesion and the Regulation of Rho GTPases
    Keith Burridge; Fiscal Year: 2013
    ..This grant is aimed at understanding how signals from cell-matrix adhesions regulate members of the Rho family of GTPases, which are themselves key regulators of the cytoskeleton and many ..
  41. The role of CTGF in bone cell development and function
    Steven N Popoff; Fiscal Year: 2012
    ..that osteoblasts attach to CTGF via the av[unreadable]5 integrin, resulting in the formation of focal adhesions, cytoskeletal reorganization and the activation of FAK and Erk...
  42. STRUCTURAL DYNAMICS OF VINCULIN IN ADHESION JUNCTIONS
    Tina Izard; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The formation of cell-matrix (focal adhesions) and cell-cell (adherens junctions) adhesion complexes links signals at the cell surface to the actin cytoskeleton, and these direct cell migration, cell ..
  43. Protein kinase B (Akt)-mediated pathway regulating endothelial-barrier function
    SOMANATH P RAMMOHAN SHENOY; Fiscal Year: 2013
    ..results, we postulate that the events leading to VP, such as expression and/or dynamics of integrins, focal adhesions, cytoskeletal proteins and cortical actin, are dependent on the ability of Akt to differentially modulate 2-Pix-..
  44. Novel role of AQP2 in cell migration and kidney tubular injury and repair
    HUA A LU; Fiscal Year: 2013
    ..interacts with integrin [unreadable]1, modulates the trafficking and turnover of integrin [unreadable]1 at focal adhesions (FAs)...
  45. Image-Guided Surgery of Endocrine Glands and Their Tumors using Near-Infrared Flu
    John V Frangioni; Fiscal Year: 2013
    ..tissues, such as the thyroid gland and adrenal gland, can often be difficult to locate during surgery due to adhesions and overlying fascia...
  46. Characterization of a novel protein required for glomerular podocyte function
    LORI L O'BRIEN; Fiscal Year: 2012
    ..As active calpains promote detachment of cellular adhesions, the current hypothesis is that PGAF inhibits calpain activity in podocytes to prevent foot process detachment...
  47. Actin protrustions, oocytes: Myosin VIIA and the actin cytoskeleton
    JENNIFER LEIGH SALLEE; Fiscal Year: 2012
    ..microscopy, focusing on irregularities in actin rich structures such as ring canals, microvilli, and cell-cell adhesions. Together these aims will provide insight into how protein complexes are contributing to ck/Myosin VIIA function ..
  48. Peptide therapeutics for inhibiting abdominal adhesions
    CYNTHIA ELLEN LANDER; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Disease definition: Adhesions, fibrous scars abnormally conjoining adjacent tissues, are primarily caused by surgical procedures...
  49. Novel Mechanisms of NSAID-induced GI Toxicity
    James D Lillich; Fiscal Year: 2012
    ..determine if NSAIDs impair de-adhesion of cell contacts by measuring the number and distribution of cellular adhesions as well as the expression and rate of turnover of specific adhesion components...
  50. Phosphoinsitide signaling in Breast Epithelial Morphogenesis and Metastasis
    Kun Ling; Fiscal Year: 2013
    ..interactions generally inhibit cell migration and cancer metastasis, whereas integrin signals at cell-matrix adhesions are required for migration and metastasis...
  51. Actions of the Sodium-Hydrogen Exchanger Subtype, NHE1
    Diane L Barber; Fiscal Year: 2012
    ..In Aim 3 we determine the role of NHE1-regulated focal adhesion proteins in remodeling cell-substrate adhesions and in directed migration of fibroblasts...
  52. The Role of Osteoactivin in Osteoblast Development and Function
    Fayez F Safadi; Fiscal Year: 2013
    ..that osteoblasts attach to OA via the [unreadable]v[unreadable]1 integrin, resulting in the formation of focal adhesions, cytoskeletal reorganization and the activation of FAK...
  53. Mutations in Smooth Muscle Contractile Proteins: Pathways to Vascular Diseases
    Dianna M Milewicz; Fiscal Year: 2013
    ..of function" in muscular arteries, specifically increased SMC proliferation as a consequence of altered focal adhesions and activation of PDGFR-Beta receptors in response to abnormal cellular force generation...
  54. Cytoskeletal regulation of T cell-APC interactions
    Anna Huttenlocher; Fiscal Year: 2012
    ..contact sites, known as the immune synapse, share many structural components with integrin-mediated focal adhesions, we have demonstrated that the adhesive mechanisms that regulate T cell-APC contact site dynamics are distinct...
  55. Biophysical Regulation of Breast Differentiation
    Patricia J Keely; Fiscal Year: 2013
    ..Our hypothesis is that locally dense ECM enhances the formation of matrix adhesions that result in activation of signaling pathways linked to FAK, and that FAK is a central mediator by which ..
  56. HEF1 Coordination of Cell Cycle, Migration, and Invasion in Cancer
    Erica A Golemis; Fiscal Year: 2013
    ..HEF1 acts to assemble signaling complexes at focal adhesions in interphase cells, at the centrosome in pre-mitotic cells, and at the cilium in cells emerging from quiescence...
  57. The role of Vimentin in cell adhesion and lung cancer metastasis
    LAUREN SMITH HAVEL; Fiscal Year: 2013
    ..Vimentin is a dynamic protein whose assembly and disassembly is critical for the formation of new focal adhesions that regulate cell adhesion...
  58. Role of Irf6 in palatal epithelium
    Youssef A Kousa; Fiscal Year: 2013
    ..Third, we know that changes in Irf6 dose lead to clefting and oral adhesions in the mouse...
  59. Enhanced Tendon Healing through Growth Factor and Cell Therapies
    Stavros Thomopoulos; Fiscal Year: 2013
    ..Poor clinical outcomes typically result from early repair-site failure and the formation of adhesions between the tendon and its surrounding synovial sheath...
  60. Zosteric Acid Integrated Thermo-reversible Gels for Preventing Surgical Adhesions
    Bi min Newby; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The development of adhesions following surgery represents a significant, costly morbidity typically expressed as pain and infertility in the patient...
  61. Device for Surgical Adhesion Prevention
    REKHA BANSAL; Fiscal Year: 2010
    ..S. where the patient is at risk for the complications from surgical adhesions. After surgery, fibrous adhesions form in the peritoneum, central nervous system, pericardium, pleura and ..
  62. MULTIDISCIPLINARY STRUCTURES AT VASCULAR CELL SURFACES
    Timothy A Springer; Fiscal Year: 2013
    ..Project 6 (Eck) examines signaling at focal adhesions and explores activation of the tyrosine kinase of FAK by phosphatidylinositol phosphates through use of ..
  63. Obstruction-initiated mechanotranscription in colonic smooth muscle cells
    Xuan Zheng Shi; Fiscal Year: 2012
    ..Numerous pathological conditions, including adhesions, carcinomas, and Hirschsprung's disease, result in obstruction in the gut...
  64. Structure and function of the integrin-linked kinase-PINCH-parvin complex
    David A Calderwood; Fiscal Year: 2012
    ..networks, and in mammalian systems IPP complex formation precedes and is required for its correct targeting to adhesions. There are currently significant deficiencies in our understanding of how the IPP complex forms, how it ..
  65. Aqueous humor dynamics studies in vivo and in vitro
    PAUL LEON KAUFMAN; Fiscal Year: 2010
    ..be enhanced by ILK, PI3K and Src kinase inhibitors, which have been shown to alter the cytoskeleton and cellular adhesions of trabecular meshwork (TM) cells in culture...
  66. Endogenous Hormones and Risk of Endometriosis
    Stacey Missmer; Fiscal Year: 2009
    ..The consequence is the development of adhesions, scarring, and painful inflammation...
  67. Xenobiotics and Breast Epithelial Cell-ECM Signaling
    Raymond Novak; Fiscal Year: 2005
    ..Cells are linked to the ECM via integrin-containing focal adhesions. Other types of structures that link cells to each other or to the ECM include adherens junctions and desmosomes...
  68. G Proteins and Endothelial Barrier Regulation
    Tatyana Voyno Yasenetskaya; Fiscal Year: 2004
    ..that G-alpha13 protein interacts with the actin-binding protein, radixin, implicated in the assembly of focal adhesions and actin filaments...
  69. A new absorbable mesh for hernia repair
    David Martin; Fiscal Year: 2007
    ..The absorbability of the mesh would reduce late term fistula and risk of infection and possibly tissue adhesions. Greater flexibility of the fiber will reduce mesh stiffness and eventual absorption will reduce the stiffness ..
  70. Treatment of Endometriosis-Associated Pelvic Pain
    David Guzick; Fiscal Year: 2007
    ..Surgical treatment of endometriosis with laparoscopic excision of implants and lysis of adhesions is often successful in reducing pain in the short term...
  71. MOLECULAR MECHANISMS OF NEURONAL CELL MIGRATION
    Richard Cameron; Fiscal Year: 2000
    ..At present, data indicate that members of several distinct classes of cell adhesions proteins are likely to mediate many of the cell sorting events that characterize neuronal cell migration...
  72. THREE DIMENSIONAL STRUCTURE OF ALPHA ACTININ
    Kenneth Taylor; Fiscal Year: 2000
    ..In tissue cultured cells, alpha-actinin is located in focal adhesions and stress fibers, structural analogs of adhesion plaques and dense bodies...
  73. A Novel Approach to Prevent Periduaral Fibrosis
    James Pachence; Fiscal Year: 2001
    ..Although inflammation and production of extracellular matrix components is necessary for normal wound healing, adhesions may also occur which can lead to significant clinical complications...
  74. Sutureless Resorbable Anti-Adhesion Films
    MICHAEL J DANILICH; Fiscal Year: 2010
    Postoperative adhesions are an expected outcome with nearly every abdominal operation. Complications caused by adhesions include small bowel obstruction, female infertility, chronic debilitating pain, and difficulty in future operations...