pathologic processes


Summary: The abnormal mechanisms and forms involved in the dysfunctions of tissues and organs.

Top Publications

  1. pmc Transforming growth factor-beta - and tumor necrosis factor-alpha -mediated induction and proteolytic activation of MMP-9 in human skin
    Y P Han
    Division of Plastic and Reconstructive Surgery, University of Southern California School of Medicine, Los Angeles, California 90033, USA
    J Biol Chem 276:22341-50. 2001
  2. ncbi [Nitric oxide, from vascular physiology to therapeutics]
    S Adnot
    , ,
    Arch Mal Coeur Vaiss 87:41-51. 1994
  3. ncbi Specificity of intertubular capillary changes: comparative ultrastructural studies in renal allografts and native kidneys
    C B Drachenberg
    Department of Pathology, University of Maryland School of Medicine, Baltimore, USA
    Ultrastruct Pathol 21:227-33. 1997
  4. ncbi Cholecystokinin-B (CCK-B)/gastrin receptor targeting peptides for staging and therapy of medullary thyroid cancer and other CCK-B receptor expressing malignancies
    Martin Behe
    Department of Nuclear Medicine of the Philipps University of Marburg, Marburg, Germany
    Biopolymers 66:399-418. 2002
  5. ncbi [Behavior disorders during REM sleep. Two clinical cases]
    A Manquillo
    , , Madrid,
    Rev Neurol 28:1170-4. 1999
  6. ncbi Pathophysiologic role of oxygen-free radicals in toxic damage of the liver
    K Janicki
    1st Department of Surgery and Transplantology, Medical University of Lublin
    Ann Univ Mariae Curie Sklodowska Med 56:201-6. 2001
  7. pmc Role of oxidative stress in female reproduction
    Ashok Agarwal
    Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Glickman Urological Institute and Department of Obstetrics Gynecology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Reprod Biol Endocrinol 3:28. 2005
  8. ncbi Bony and vascular anatomy of the normal cervical spine in the sheep
    C C Cain
    Department of Orthopaedic Surgery and Trauma, Royal Adelaide Hospital, South Australia
    Spine (Phila Pa 1976) 20:759-65. 1995
  9. pmc CCKB/gastrin receptor antagonists: recent advances and potential uses in gastric secretory disorders
    R T Jensen
    National Institutes of Health, Bethesda, Maryland 20892-1804, USA
    Yale J Biol Med 69:245-59. 1996
  10. ncbi The physiological and pharmacological significance of cardiovascular T-type, voltage-gated calcium channels
    D J Triggle
    State University of New York at Buffalo, 14260, USA
    Am J Hypertens 11:80S-87S. 1998

Detail Information

Publications220 found, 100 shown here

  1. pmc Transforming growth factor-beta - and tumor necrosis factor-alpha -mediated induction and proteolytic activation of MMP-9 in human skin
    Y P Han
    Division of Plastic and Reconstructive Surgery, University of Southern California School of Medicine, Los Angeles, California 90033, USA
    J Biol Chem 276:22341-50. 2001
    Both cytokines and matrix metalloproteinases (MMPs) are active during physiologic and pathologic processes such as cancer metastasis and wound repair. We have systematically studied cytokine-mediated MMP regulation...
  2. ncbi [Nitric oxide, from vascular physiology to therapeutics]
    S Adnot
    , ,
    Arch Mal Coeur Vaiss 87:41-51. 1994
    ..The inhalation of NO, which is increasingly used in neonatal and adult intensive care units, is an alternative therapeutic approach in many conditions associated with pulmonary hypertension...
  3. ncbi Specificity of intertubular capillary changes: comparative ultrastructural studies in renal allografts and native kidneys
    C B Drachenberg
    Department of Pathology, University of Maryland School of Medicine, Baltimore, USA
    Ultrastruct Pathol 21:227-33. 1997
    ..This association is particularly true for cases with severe ITC abnormalities...
  4. ncbi Cholecystokinin-B (CCK-B)/gastrin receptor targeting peptides for staging and therapy of medullary thyroid cancer and other CCK-B receptor expressing malignancies
    Martin Behe
    Department of Nuclear Medicine of the Philipps University of Marburg, Marburg, Germany
    Biopolymers 66:399-418. 2002
    ..They allow for a sensitive and reliable staging of patients with metastatic MTC. Initial therapeutic results are promising, but nephrotoxicity is a major concern to be solved...
  5. ncbi [Behavior disorders during REM sleep. Two clinical cases]
    A Manquillo
    , , Madrid,
    Rev Neurol 28:1170-4. 1999
    ..Finally we consider the pharmacological treatment of this disorder...
  6. ncbi Pathophysiologic role of oxygen-free radicals in toxic damage of the liver
    K Janicki
    1st Department of Surgery and Transplantology, Medical University of Lublin
    Ann Univ Mariae Curie Sklodowska Med 56:201-6. 2001
    ..The histological preparations were evaluated in electron microscope. In all the experimental groups adaptative and probably temporary histopathological changes were noted in the liver. The observed damages were probably reversible...
  7. pmc Role of oxidative stress in female reproduction
    Ashok Agarwal
    Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Glickman Urological Institute and Department of Obstetrics Gynecology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Reprod Biol Endocrinol 3:28. 2005
    ..Serial measurement of oxidative stress biomarkers in longitudinal studies may help delineate the etiology of some of the diosorders in female reproduction such as preeclampsia...
  8. ncbi Bony and vascular anatomy of the normal cervical spine in the sheep
    C C Cain
    Department of Orthopaedic Surgery and Trauma, Royal Adelaide Hospital, South Australia
    Spine (Phila Pa 1976) 20:759-65. 1995
    ..CONCLUSIONS. To properly assess the effect of various pathological processes on the spinal cord, an anatomically valid model is required. This study established that the sheep is a suitable animal model for studies of this type...
  9. pmc CCKB/gastrin receptor antagonists: recent advances and potential uses in gastric secretory disorders
    R T Jensen
    National Institutes of Health, Bethesda, Maryland 20892-1804, USA
    Yale J Biol Med 69:245-59. 1996
    ..Knowledge of the physiological role and role of CCKB receptors in pathologic processes has been particularly limited by the availability of selective, potent receptor antagonists...
  10. ncbi The physiological and pharmacological significance of cardiovascular T-type, voltage-gated calcium channels
    D J Triggle
    State University of New York at Buffalo, 14260, USA
    Am J Hypertens 11:80S-87S. 1998
    ..also seem to have an important role in normal growth processes and in the tissue remodeling that occurs in pathologic processes such as cardiac hypertrophy. Traditional calcium antagonists act on L-type channels...
  11. ncbi [Cysteine proteinase and neurodegeneration]
    J Jordan
    Instituto de Neurociencias, Facultad de Medicina, Universidad Miguel Hernandez, Alicante, Espana
    Rev Neurol 31:333-40. 2000
    ..This is a review of the part played by the cysteine proteases in different physiological and pathological processes...
  12. ncbi Generation of a specific immunological response to FGF-2 does not affect wound healing or reproduction
    Stacy M Plum
    EntreMed, Inc, Rockville, Maryland 20850, USA
    Immunopharmacol Immunotoxicol 26:29-41. 2004
    ..capillary formation from pre-existing vessels, has been established as an important mechanism involved in pathologic processes, such as cancer, as well as in normal physiology (Ribatti, D.; Vacca, A.; Roncali, L.; Dammacco, F...
  13. ncbi The development and pathologic processes that influence maxillary sinus pneumatization
    William Lawson
    Department of Otolaryngology, Mount Sinai Medical Center, New York, New York 10029, USA
    Anat Rec (Hoboken) 291:1554-63. 2008
    ..Fibro-osseous disorders similarly produce size and shape distortions by external impingement. Although diverse developmental and pathological conditions influence maxillary sinus morphology, there is a limited range of biologic response...
  14. ncbi Biological activities of the natural imidazole-containing peptidomimetics n-acetylcarnosine, carcinine and L-carnosine in ophthalmic and skin care products
    Mark A Babizhayev
    Innovative Vision Products, Inc, 3511 Silverside Road, Suite 105, County of New Castle, Delaware 19810, USA
    Life Sci 78:2343-57. 2006
    ..The biologically significant applications of carnosine mimetics were patented by Dr. Babizhayev and the alliance Groups (WO 2004/028536 A1; WO 94/19325; WO 95/12581; WO 2004/064866 A1)...
  15. ncbi Histopathologic correlation of magnetic resonance imaging signal patterns in a spinal cord injury model
    S D Weirich
    Division of Orthopaedic Surgery, University of Texas Health Science Center, Houston
    Spine (Phila Pa 1976) 15:630-8. 1990
    ..Magnetic resonance imaging delineates the pathologic processes resulting from acute spinal cord injury and can be used to differentiate the type of injury and prognosis.
  16. ncbi Immunolocalization of bone morphogenetic protein and its receptors in degeneration of intervertebral disc
    R Takae
    Department of Physical Therapy, School of Allied Medical Sciences
    Spine (Phila Pa 1976) 24:1397-401. 1999
    ..SUMMARY OF BACKGROUND DATA: Biologic and pathologic processes in the cell during the degeneration of the intervertebral disc are as yet poorly understood...
  17. ncbi Compression of the upper cervical spinal cord causing symptoms of brainstem compromise. A case report
    W S Rosenberg
    Department of Neurosurgery, University of California, San Francisco, USA
    Spine (Phila Pa 1976) 23:1497-500. 1998
    ..SUMMARY OF BACKGROUND DATA: Pathologic processes at the craniocervical junction may cause brainstem compromise with neurologic symptoms...
  18. ncbi [Neuronal plasticity]
    I Pascual Castroviejo
    , Hospital La Paz, Madrid
    Rev Neurol 24:1361-6. 1996
    ..In pediatric Neurology, the concept of brain plasticity is frequently used to explain the favourable clinic evolution in a lot of cases with severe brain injury...
  19. ncbi Dermal Wound Fibroblasts and Matrix Metaloproteinases (MMPs): Their Possible Role in Allergic Contact Dermatitis
    Mohammad Reza Khorramizadeh
    Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Iran J Allergy Asthma Immunol 3:7-11. 2004
    ..In particular, MMP-2 is postulated to be an aim for further gene therapy protocols...
  20. ncbi Effect of steroid hormones and retinoids on the formation of capillary-like tubular structures of human microvascular endothelial cells in fibrin matrices is related to urokinase expression
    M Lansink
    Gaubius Laboratory TNO PG, Leiden, The Netherlands
    Blood 92:927-38. 1998
    ..These effects can be explained by hormone-receptor-mediated changes in u-PA expression, resulting in enhanced local proteolytic capacity of the u-PA/u-PA receptor complex...
  21. ncbi Headache and sferics
    D Vaitl
    Department of Clinical and Physiological Psychology, Justus-Liebig, University of Giessen, Otto-Behaghel-Strasse 10, D-35394 Giessen, Germany
    Headache 41:845-53. 2001
    ..In summer, tension-type headaches were associated with other weather parameters such as temperature (r = 0.36, P<.01) and vapor pressure (r = 0.27, P<.05)...
  22. ncbi Does variability in carotenoid composition and concentration in tissues of the breast and reproductive tract in women depend on type of lesion?
    E Czeczuga-Semeniuk
    Department of Reproduction and Gynecological Endocrinology, Medical University of Białystok, Białystok, Poland
    Adv Med Sci 53:270-7. 2008
    ..The study objective was to compare the carotenoid content in benign and malignant lesions of the breast, ovary and uterus, and to demonstrate quantitative and qualitative similarities or differences between the study groups...
  23. ncbi Selected growth factors in peritoneal dialysis: their relationship to markers of inflammation, dialysis adequacy, residual renal function, and peritoneal membrane transport
    Tomasz Stompor
    Department of Nephrology, Jagiellonian University, Krakow, Poland
    Perit Dial Int 22:670-6. 2002
    ..inflammation, acute-phase reactants, and growth factors may be concomitantly involved in a number of pathologic processes in the general population and uremic patients...
  24. ncbi [Composition and structure of the neuronal membrane: molecular basis of its physiology and pathology]
    C Gimenez
    Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias Universidad Autónoma de Madrid, Espana
    Rev Neurol 26:232-9. 1998
  25. ncbi [Parkinson disease of juvenile onset with systemic lupus erythematosus in a pre-symptomatic stage]
    J Chacon
    Servicio de Neurologia, Hospital Virgen de la Macarena, Sevilla, Espana
    Rev Neurol 29:725-7. 1999
  26. ncbi Isolation and characterization of ellagic acid derivatives isolated from Casearia sylvestris SW aqueous extract with anti-PLA(2) activity
    Saulo L Da Silva
    Campus Avançado de Divinópolis, Universidade Fed de São João Del Rei, CEP 35501 296 Divinópolis, MG, Brazil
    Toxicon 52:655-66. 2008
    ..SW (Flacourtiaceae) is utilized in folk medicine (Brazil and all Latin American) to treat several pathologic processes as inflammation, cancer, microbial infection and snake bites. Studies showed that C...
  27. ncbi Basic pathologic processes in the nervous system
    J W Griffin
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Toxicol Pathol 18:83-8. 1990
    ..In the future, new screening techniques based on immunocytochemical analyses and measurement of specific mRNA levels can be anticipated...
  28. ncbi Disarticulation resections of the mandible: a prospective review of 16 cases
    Eric R Carlson
    Division of Oral and Maxillofacial Surgery, University of Miami School of Medicine, Miami, FL 33136, USA
    J Oral Maxillofac Surg 60:176-81. 2002
    ..Recommendations are also proposed for preservation versus sacrifice of the meniscus when performing a disarticulation resection of the mandible. Finally, complications are evaluated in this type of mandibular resection...
  29. ncbi [Polymorphism of gene promotor region for MMP-2 in rheumatoid arthritis]
    P Nemec
    Revmatologická ambulance II interní kliniky Lékaské fakulty MU a FN u sv Anny, Brno
    Vnitr Lek 52:348-54. 2006
    ..Increased levels of MMP-2 (gelatinase A) are observed in serum and synovial fluid of patients with RA. Gene polymorphism for MMP-2 can affect susceptibility to development and/or severity of RA...
  30. ncbi Hepatobiliary scintigraphy in children
    H R Nadel
    Department of Radiology, British Columbia s Children s Hospital, Vancouver, Canada
    Semin Nucl Med 26:25-42. 1996
    ..Hepatobiliary imaging in children who have undergone liver transplantation will assess graft vascularity, parenchymal function, biliary drainage, presence of a leak, and obstruction...
  31. ncbi Expression of insulin-like growth-factor-1 receptor (IGF-1R) in peripheral nerve sheath tumors in neurofibromatosis type 1
    R E Friedrich
    Maxillofacial Surgery Clinic, Eppendorf University Hospital, University of Hamburg, Germany
    Anticancer Res 27:2085-90. 2007
    ..Factor and receptor are involved in the growth control of numerous physiological and pathological processes, including Schwann cell development...
  32. ncbi Increased transforming growth factor-beta(1) circulating levels and production in human monocytes after 3-hydroxy-3-methyl-glutaryl-coenzyme a reductase inhibition with pravastatin
    Ettore Porreca
    Department of Medicine and Aging, Atherosclerosis and Thrombosis Section, University of Chieti Medical School, Via dei Vestino, 66013 Chieti, Italy
    J Am Coll Cardiol 39:1752-7. 2002
  33. pmc Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases
    Douglas B Kell
    School of Chemistry and Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess St, Manchester, M1 7DN, UK
    BMC Med Genomics 2:2. 2009
    ..Understanding these requires an integrative, systems-level approach that may lead to novel therapeutic targets...
  34. ncbi Overexpression of G protein-coupled receptors in cancer cells: involvement in tumor progression
    Shuyu Li
    Integrative Biology, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Int J Oncol 27:1329-39. 2005
  35. pmc Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors
    Roberta Noberini
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Biol Chem 283:29461-72. 2008
    ..Furthermore, the newly identified inhibitors represent possible leads for the development of therapies to treat pathologies in which EphA4 and EphA2 are involved, including nerve injuries and cancer...
  36. ncbi Transepithelial elimination of cutaneous vulval granuloma inguinale
    P K Ramdial
    Department of Anatomical Pathology, School of Pathology and Laboratory Medicine, University of Natal, Durban, South Africa
    J Cutan Pathol 27:493-9. 2000
  37. ncbi New insights in the DNA-[Cr(phen)2(dppz)]3+ binding and photocleavage properties by the complex with an intercalating ligand
    Judith Toneatto
    INFIQC CONICET, Dpto de Fisicoquimica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, 5000 Cordoba, Argentina
    J Inorg Biochem 104:697-703. 2010
    ..In sum, our results allow us to postulate the [Cr(phen)(2)(dppz)](3+) complex as a very attractive candidate for DNA photocleavage with potential applications in Photodynamic Therapy (PDT)...
  38. ncbi Towards understanding the kallikrein-kinin system: insights from measurement of kinin peptides
    D J Campbell
    St Vincent s Institute of Medical Research, Fitzroy, Victoria, Australia
    Braz J Med Biol Res 33:665-77. 2000
    ..Measurement of the levels of individual kinin peptides has given important information about the operation of the kallikrein-kinin system and its role in physiology and disease states...
  39. ncbi Development of the ethmoid sinus and extramural migration: the anatomical basis of this paranasal sinus
    Samuel Márquez
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
    Anat Rec (Hoboken) 291:1535-53. 2008
    Frontal and/or maxillary sinusitis frequently originates with pathologic processes of the ethmoid sinuses...
  40. ncbi Functional role of alpha-actinin, PI 3-kinase and MEK1/2 in insulin-like growth factor I receptor kinase regulated motility of human breast carcinoma cells
    Marina A Guvakova
    Department of Microbiology, University of Pennsylvania, 3610 Hamilton Walk, 211 Johnson Pavilion, Philadelphia PA 19104, USA
    J Cell Sci 115:4149-65. 2002
  41. ncbi Analyzing cell mechanics in hematologic diseases with microfluidic biophysical flow cytometry
    Michael J Rosenbluth
    Department of Bioengineering, 608B Stanley Hall, Berkeley, CA 94720 3220, USA
    Lab Chip 8:1062-70. 2008
    ..Biophysical flow cytometry offers a low-cost and high-throughput diagnostic and drug discovery platform for hematologic diseases that affect microcirculatory flow...
  42. ncbi Immunolocalization of VEGF, VEGFR-1 and VEGFR-2 in lung tissues after acute hemorrhage in rats
    Nuran Ekerbicer
    Department of Physiology, Faculty of Medicine, Celal Bayar University, Dekanlik Binasi, Uncubozkoy Mevkii, 45030 Manisa, Turkey
    Acta Histochem 110:285-93. 2008
    ..In summary, the vascular protecting effects of these factors were observed with fluid resuscitation, contributing to the pathophysiological changes seen in hypovolemia...
  43. pmc Structure, regulation, and pathophysiology of tight junctions in the gastrointestinal tract
    M S Balda
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510
    Yale J Biol Med 65:725-35; discussion 737-40. 1992
    ..we consider experimental evidence defining how the barrier properties of junctions are physiologically regulated and, third, how barrier properties are specifically altered in, and contribute to, pathologic processes affecting epithelia.
  44. ncbi Anoikis in the cardiovascular system: known and unknown extracellular mediators
    Jean Baptiste Michel
    INSERM Unit 460, CHU Xavier Bichat, 46, rue Henri Huchard, 75877 Paris Cedex 18, France
    Arterioscler Thromb Vasc Biol 23:2146-54. 2003
    ..However, the exact role of anoïkis in cardiovascular pathologies remains to be further defined...
  45. ncbi Dual effect of exogenous hydrogen sulfide on the spontaneous contraction of gastric smooth muscle in guinea-pig
    Peng Zhao
    Department of Physiology, Shanghai Jiaotong University School of Medicine, 800 Dongchuan Road, 328 Wenxuan Medical Building, Shanghai 200240, China
    Eur J Pharmacol 616:223-8. 2009
    ..An excitatory effect is mediated via inhibition of the voltage-gated K(+) channel and an inhibitory effect is mediated via activation of the K(ATP) channel...
  46. ncbi Endoscopic endonasal surgery for biopsy of cavernous sinus lesions
    H S Liu
    Department of Neurosurgery, Affiliated Yu Qian Hospital of Qing Hua University, Beijing, People s Republic of China
    Minim Invasive Neurosurg 52:69-73. 2009
    ..The authors present a new application to endoscopic endonasal surgery for the biopsy of lesions arising from or invading the cavernous sinus...
  47. ncbi Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation
    Gerald S Horan
    Department of Exploratory Biology, Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, USA
    Am J Respir Crit Care Med 177:56-65. 2008
  48. ncbi Assessment and management of pressure ulcers in the elderly: current strategies
    Efraim Jaul
    Skilled Geriatric Nursing Department, Herzog Hospital, Jerusalem, Israel
    Drugs Aging 27:311-25. 2010
    ..This article discusses the pathogenesis of pressure ulcer development in the elderly in relation to concomitant diseases, risk factor assessment and the management of such ulcers...
  49. ncbi Beta-carotene inhibits tumor-specific angiogenesis by altering the cytokine profile and inhibits the nuclear translocation of transcription factors in B16F-10 melanoma cells
    C Guruvayoorappan
    Department of Immunology, Amala Cancer Research Centre, Amala Nagar, Kerala State, India
    Integr Cancer Ther 6:258-70. 2007
    ..These observations show that beta -carotene exerts its antiangiogenic effect by altering the cytokine profile and could inhibit the activation and nuclear translocation of transcription factors...
  50. ncbi Site-directed mutagenesis of alpha II spectrin at codon 1175 modulates its mu-calpain susceptibility
    P R Stabach
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Biochemistry 36:57-65. 1997
    ..Their action is implicated in an array of cellular and pathologic processes, including long-term potentiation, synaptic remodeling, protein kinase C and steroid receptor activation, ..
  51. ncbi Oxidation and inactivation of SERCA by selective reaction of cysteine residues with amino acid peroxides
    Elena S Dremina
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence 66047, USA
    Chem Res Toxicol 20:1462-9. 2007
    ..Our data demonstrate a potential role of peptide- and protein-derived peroxides as important mediators of oxidative stress in vivo, which may cause a selective oxidation of Cys residues leading to inactivation of membrane proteins...
  52. ncbi [Jugular megabulb as a cause of pulsatile tinnitus]
    S Abilleira
    , Hospital General Universitari de la Vall d Hebron, Barcelona,
    Rev Neurol 25:1422-4. 1997
    ..CONCLUSIONS: The presence of AP may be for many years the only sign of subjacent vascular pathology, such as a megabulb of the jugular vein...
  53. ncbi [Psychogenic paroxysmal disorders in children]
    F Mulas
    , Hospital Infantil Universitario La Fe Valencia,
    Rev Neurol 28:81-3. 1999
    ..Amongst these investigations, we emphasize the importance of the video-EEG for differential diagnosis of paroxystic disorders in children...
  54. pmc Characterization of the ovine ribosomal protein SA gene and its pseudogenes
    Alice Van den Broeke
    Department of Nutrition, Genetics and Ethology, Faculty of Veterinary Medicine, Ghent University, Heidestraat 19, Merelbeke, Belgium
    BMC Genomics 11:179. 2010
    ..The present work aims at deciphering the RPSA family in sheep...
  55. ncbi Molecular biology of HMGA proteins: hubs of nuclear function
    R Reeves
    Department of Biochemistry and Biophysics, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4660, USA
    Gene 277:63-81. 2001
    ..This review covers recent advances that have contributed to our understanding of how this constellation of structural and biological features allows the HMGA proteins to serve as central 'hubs' of nuclear function...
  56. ncbi Nitric oxide and cellular stress response in brain aging and neurodegenerative disorders: the role of vitagenes
    Vittorio Calabrese
    Section of Biochemistry and Molecular Biology, Department of Chemistry, Faculty of Medicine, University of Catania, Catania, Italy
    In Vivo 18:245-67. 2004
    ..Consistent with this notion, maintenance or recovery of the activity of vitagenes may possibly delay the aging process and decrease the occurrence of age-related diseases with resulting prolongation of a healthy life span...
  57. ncbi Alcohol reduces GM1 ganglioside content in the serum of inbred mouse strains
    Mitsuo Saito
    Division of Analytical Psychopharmacology, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Alcohol Clin Exp Res 28:1107-13. 2004
    Endogenous and exogenous gangliosides in the plasma affect physiologic and pathologic processes such as angiogenesis and atherogenesis...
  58. ncbi Accelerated evolution of Fetuin-A (FETUA, also AHSG) is driven by positive Darwinian selection, not GC-biased gene conversion
    Yvonne Döring
    Institute for Molecular Cardiovascular Research, University Hospital Aachen, 52074 Aachen, Germany
    Gene 463:49-55. 2010
    ..The script is available upon request and the presented approach of testing the extended null hypothesis of molecular evolution can be transferred to every other protein coding locus...
  59. ncbi Linker histone H1 binds to disease associated amyloid-like fibrils
    James A Duce
    Centre for Neuroscience, The University of Melbourne, Victoria 3010, Australia
    J Mol Biol 361:493-505. 2006
    ..We conclude that the binding of histone H1 to a general amyloid-like motif indicates that histone H1 may play an important common role in diseases associated with amyloid-like fibrils...
  60. ncbi The relationship of brain and cervical cord volume to disability in clinical subtypes of multiple sclerosis: a three-dimensional MRI study
    X Lin
    Division of Clinical Neurology, Faculty of Medicine, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Acta Neurol Scand 108:401-6. 2003
    ..We aimed at measuring volume in different parts of the central nervous system, and its relationship with clinical measures, in relapsing-remitting (RR) and secondary progressive (SP) MS patients...
  61. ncbi The renin receptor: the facts, the promise and the hope
    Genevieve Nguyen
    National Institute for Health and Medical Research, INSERM Unit 489, Tenon Hospital, Paris, France
    Curr Opin Nephrol Hypertens 12:51-5. 2003
    ..The search for a receptor of renin was based on the idea that tissue (pro)renin is taken up from the circulation and on data suggesting that renin has cellular effects independent of angiotensin II...
  62. pmc Activated endothelium binds lymphocytes through a novel binding site in the alternately spliced domain of vascular cell adhesion molecule-1
    L Osborn
    Biogen, Inc, Cambridge, Massachusetts 02142
    J Exp Med 176:99-107. 1992
    ..Therefore both sites must be blocked in clinical, animal, or in vitro studies depending on the use of anti-VCAM-1 antibodies to inactivate the VCAM-1/VLA-4 adhesion pathway...
  63. ncbi Lipidomic processes in homeostatic and LPS-modified cell renewal cycle. Role of phosphatidylinositol 3-kinase pathway in biomembrane synthesis and restitution of apical epithelial membrane
    A Slomiany
    Research Center University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    J Physiol Pharmacol 54:533-51. 2003
  64. ncbi In situ hybridization in the study of remodeling in proliferative glomerulonephritis
    J L Barnes
    The Medical Research Service, Audie Murphy Memorial Veterans Administration Hospital, San Antonio, Texas 78284, USA
    Toxicol Pathol 26:43-51. 1998
    ..between cellular sources of mRNA and localization of translated protein in normal biologic and pathologic processes. In this symposium, techniques in probe selection for the detection of mRNA in normal kidney and renal ..
  65. ncbi Acidic fibroblast growth factor (FGF-1) and FGF receptor 1 signaling in human Y79 retinoblastoma
    Sandrine Siffroi-Fernandez
    Laboratoire de Physiopathologie Cellulaire et Moleculaire de la Retine, Institut National de la Santé et de la Récherche Médicale Université Louis Pasteur U 592, Centre Hospitalier Universitaire Régional, Strasbourg, France
    Arch Ophthalmol 123:368-76. 2005
    ..Little is known about their possible implication in retinoblastoma growth. We sought to examine FGF high- and low-affinity receptor (FGFR) expression, activation of FGFR1 by acidic FGF (FGF-1), and proliferative effects on Y79 cells...
  66. ncbi Up-regulation of cystatin C expression in the murine hippocampus following perforant path transections
    G X Ying
    Key Laboratory of Neurobiology, Shanghai Institute of Physiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China
    Neuroscience 112:289-98. 2002
  67. ncbi [Diagnostic imaging and differential diagnosis of pathological processes of the sinus cavernosus]
    T J Vogl
    Institut für Diagnostische und Interventionelle Radiologie, Johann Wolfgang Goethe Universitat Frankfurt Main
    Radiologe 43:161-70. 2003
    ..Digital subtraction angiography as an invasive technique is used during therapeutic procedures such as the local treatment of aneurysms or carotid-cavernous fistulas...
  68. ncbi Cardiac troponin T vs other biochemical markers in patients with congestive heart failure
    Yukiko Nishio
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Circ J 71:631-5. 2007
    Several pathologic processes can cause myocardial injury, which is followed by cardiac remodeling and congestive heart failure (CHF)...
  69. pmc Novel MMP-9 substrates in cancer cells revealed by a label-free quantitative proteomics approach
    Danmei Xu
    Radiation Oncology and Biology, Medical Science Division, Churchill Hospital, University of Oxford, Oxford OX3 7LJ, United Kingdom
    Mol Cell Proteomics 7:2215-28. 2008
  70. ncbi Identification of fucosylated glycoconjugates in Xenopus laevis testis by lectin histochemistry
    Galder Valbuena
    Departamento de Biología Celular e Histología, Facultad de Medicina y Odontologia, Universidad del Pais Vasco Euskal Herriko Unibertsitatea, 48940 Leioa Vizcaya, Spain
    Histochem Cell Biol 134:215-25. 2010
    ..Labelling with AAL could be explained by the fact that this lectin could be binding to diverse fucosylated glycans in N- and O-glycans, and even in glycolipids. The importance of these glycans is discussed...
  71. ncbi Rudolf Virchow and presentation of his scientific achievement in Polish medical magazines in the 19th century and the beginning of 20th century
    Daniel Sabat
    Department of Pathomorphology, Medical Faculty in Zabrze, Silesian Academy of Medicine, Katowice
    Pol J Pathol 53:163-8. 2002
    ..In 1858, his theory of cellular pathology became a basis for the understanding and fight against pathologic processes in living organisms...
  72. ncbi Incidence of acute nerve function impairment and reactions in leprosy: a prospective cohort analysis after 5 years of follow-up
    Jan H Richardus
    Department of Public Health, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Int J Epidemiol 33:337-43. 2004
    ..The objective of this study was to assess the need for and duration of surveillance of NFI...
  73. ncbi Effect of platelet activating factor with and without receptor antagonist (WEB2170) on morphology of isolated cochlear outer hair cells
    Timothy T K Jung
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, Loma Linda University School of Medicine, and Jerry L Pettis Memorial Veterans Medical Center, Loma Linda, California, USA
    Ann Otol Rhinol Laryngol 113:164-8. 2004
    ..This study demonstrated that exposure to PAF causes morphological changes in isolated OHCs that can be prevented by the PAF receptor antagonist WEB2170...
  74. ncbi The course of enzymatically induced lipid peroxidation in homogenized porcine kidney tissue
    U Kiessling
    , , Germany
    Z Naturforsch C 53:431-7. 1998
    ..These observations reflect that the generation and degradation of hydroperoxides occurs at different rates which might be of interest in pathological processes connected with tissue injury, e.g. myocardial infarction...
  75. ncbi A clinical study of degenerative spondylolisthesis. Radiographic analysis and choice of treatment
    K Satomi
    Department of Orthopaedics, School of Medicine, Keio University, Tokyo, Japan
    Spine (Phila Pa 1976) 17:1329-36. 1992
    ..Computed tomographies after myelography provided the key images for identifying pathologic processes in degenerative spondylolisthesis and selecting appropriate surgical procedures.
  76. pmc Etiology of diverticular disease with classic illustrations
    D W McCarthy
    Department of Surgery, State University of New York at Buffalo School of Medicine 14215, USA
    J Natl Med Assoc 88:389-90. 1996
    ..Theories relating to the etiology of the pathologic processes are commonly quoted, although the actual anatomic features are rarely seen during colonoscopic examinations...
  77. ncbi Prolidase dependent inhibition of collagen biosynthesis in Chinese hamster ovary cells
    Wojciech Miltyk
    Department of Pharmaceutical Analysis, Medical University in Bialystok Kilińskiego 1 15 089 Bialystok, Poland
    J Biochem 144:409-14. 2008
    ..The results presented provide evidence for important role of prolidase in collagen biosynthesis...
  78. ncbi Mapping limbic network organization in temporal lobe epilepsy using morphometric correlations: insights on the relation between mesiotemporal connectivity and cortical atrophy
    Boris C Bernhardt
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute and Hospital, Montreal, Quebec, Canada
    Neuroimage 42:515-24. 2008
    ..This divergence underlines the complexity of the pathophysiological mechanisms leading to neocortical atrophy in TLE...
  79. ncbi Pericytes as a new target for pathological processes in CADASIL
    Dorota Dziewulska
    Department of Neurology, Medical University ofWarsaw, Banacha str 1A, 02 097 Warsaw, Poland
    Neuropathology 32:515-21. 2012
  80. ncbi A structural network associated with the kallikrein-kinin and renin-angiotensin systems
    Veronika Stoka
    Department of Biochemistry and Molecular and Structural Biology, J Stefan Institute, Ljubljana, Slovenia
    Biol Chem 391:443-54. 2010
    ..From the latter, all domain interactors up to level 4 were retrieved, thus displaying a more comprehensive representation of the KKS-RAS structural network...
  81. ncbi Biodiversity and noncanonical Notch signaling
    Pascal Heitzler
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
    Curr Top Dev Biol 92:457-81. 2010
    ..In this review, we will focus on some noncanonical Notch activities and their in vivo significance during developmental and pathological processes...
  82. pmc Novel treatment targets for cerebral edema
    Brian P Walcott
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Neurotherapeutics 9:65-72. 2012
    ..A specific antagonist of the vasopressin V1A- and V2-receptor, conivaptan, promotes water excretion while sparing electrolytes through a process known as aquaresis...
  83. ncbi Four causes of cadaveric kidney transplant failure: a competing risk analysis
    David W Gjertson
    Department of Biostatistics, University of California at Los Angeles, USA
    Am J Transplant 2:84-93. 2002
    ..6% + 6.6%)] and 88.3% for Blacks and non-Blacks, respectively. The growing complexity of transplantation will benefit from new analytic approaches that accommodate multiple transitions along diverse paths to eventual graft loss or death...
  84. ncbi A case of palpable purpura and nephropathy: Occam's Razor or Hickam's Dictum
    Ranadeep Mandhadi
    1Internal Medicine, Rosalind Franklin University of Medicine and Sciences, North Chicago, IL and 2Internal Medicine, Mount Sinai Hospital Medical Center, Chicago, IL
    Am J Ther 20:572-5. 2013
    ..Thus, it was thought that nephropathy and vasculitis, in this case, are two distinct pathologic processes, both induced by infection (HIV and/or hepatitis C). The patient responded to low-dose steroid therapy...
  85. ncbi EphB3 is overexpressed in non-small-cell lung cancer and promotes tumor metastasis by enhancing cell survival and migration
    Xiao Dan Ji
    Center for Cancer Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of Chinese Academy of Sciences, Shanghai, PR China
    Cancer Res 71:1156-66. 2011
    ..of transmembrane tyrosine kinase receptors, have been increasingly implicated in various physiologic and pathologic processes, and the roles of the Eph family members during tumorigenesis have recently attracted growing attention...
  86. ncbi Optical imaging in cancer research: basic principles, tumor detection, and therapeutic monitoring
    Metasebya Solomon
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Med Princ Pract 20:397-415. 2011
    ..Moreover, optical imaging has at its disposal diverse contrast mechanisms for distinguishing normal from pathologic processes and tissues. To accommodate these signaling strategies, an array of imaging techniques has been developed...
  87. pmc miRNA-34b as a tumor suppressor in estrogen-dependent growth of breast cancer cells
    Yee Ming Lee
    Graduate Institute of Toxicology, College of Medicine, National Taiwan University, NO, 1, Sec, 1, Ren Ai Road, Taipei, 100, Taiwan
    Breast Cancer Res 13:R116. 2011
    ..In the present study, we identified the estrogen-regulated miR-34b and investigated its functional role in breast cancer progression...
  88. ncbi Quantification of circulating cell-free plasma DNA and endothelial gene RNA in patients with burns and relation to acute thermal injury
    A Fox
    Stem Cells and Immunotherapies Laboratory, NHS Blood and Transplant Service, Oxford, UK
    Burns 34:809-16. 2008
    ..Raised levels of cell-free nucleic acids have been detected in various pathological processes including burns. We quantified circulating nucleic acids as potential objective measures of burn severity with predictive and prognostic value...
  89. ncbi Neuroprotection from tissue inhibitor of metalloproteinase-1 and its nanoparticles
    Mayank Chaturvedi
    Department of Molecular and Cellular Neurobiology, Nencki Institute, Warsaw, Poland
    Neurochem Int 61:1065-71. 2012
    ..Since gelatinolytic activity assay showed a decrease in MMP-9 activity, it can be suggested that this neuroprotection might be mediated by the gelatinase inhibition...
  90. ncbi Otalgia
    Ryan E Neilan
    Department of Otolaryngology Head and Neck Surgery, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9035, USA
    Med Clin North Am 94:961-71. 2010
    ..pain in the ear, can be a consequence of otologic disease (primary or otogenic otalgia), or can arise from pathologic processes and structures other than the ear (secondary or referred otalgia)...
  91. ncbi Mast cells populations fluctuate along the spinal dura mater of the developing rat
    Helen Michaloudi
    Laboratory of Anatomy and Histology, Veterinary School, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
    Brain Res 1226:8-17. 2008
    ..The findings may be of importance in elucidating physiological and pathological processes in the dura mater and the vertebral column...
  92. ncbi Specific thermographic changes during Walker 256 carcinoma development: differential infrared imaging of tumour, inflammation and haematoma
    Marija Poljak-Blazi
    Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia
    Cancer Detect Prev 32:431-6. 2009
    ..Infrared imaging measures spatial variations in the skin temperature aiming to determine pathological processes; hence possible use of this non-invasive analytical method in cancer detection is emerging...
  93. ncbi A non-oxidative electrochemical approach to online measurements of dopamine release through laccase-catalyzed oxidation and intramolecular cyclization of dopamine
    Yuqing Lin
    Beijing National Laboratory for Molecular Sciences, Laboratory of Life Analytical Chemistry, Institute of Chemistry, the Chinese Academy of Sciences CAS, Beijing, China
    Biosens Bioelectron 25:1350-5. 2010
    ..3 microM. The high selectivity and the good linearity as well as the high stability of the online method make it very potential for continuous monitoring of cerebral DA release in physiological and pathological processes...
  94. ncbi Clinical and model research of neurotrauma
    Andras Buki
    Department of Neurosurgery, Pecs University, Pecs, Hungary
    Methods Mol Biol 566:41-55. 2009
    ..This chapter provides protocols for relevant experimental models of TBI and clinical materials for neuroproteomic analysis...
  95. ncbi Chapter 15: Live-cell single-molecule force spectroscopy
    Terrence M Dobrowsky
    Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Methods Cell Biol 89:411-32. 2008
  96. ncbi N-terminal domains of CCN family 2/connective tissue growth factor bind to aggrecan
    Eriko Aoyama
    Biodental Research Center, Okayama University Dental School, 2 5 1 Shikata cho, Kita ku, Okayama, Japan
    Biochem J 420:413-20. 2009
    ..These results indicate that CCN2/CTGF binds to aggrecan through its N-terminal IGFBP and VWC modules, and this binding may be related to the CCN2/CTGF-enhanced production and secretion of aggrecan by chondrocytes...
  97. ncbi Proteomics: clinical applications
    Delfina C Dominguez
    University of Texas at El Paso, Clinical Laboratory Science, College of Health Sciences, 1101 N Campbell Street, El Paso, TX 79902 4238, USA
    Clin Lab Sci 20:245-8. 2007
    ..Here we present an overview of proteomics applications to the study of disease and its potential to improve diagnosis and prognosis...
  98. ncbi Triple therapy for neovascular age-related macular degeneration (verteporfin photodynamic therapy, intravitreal dexamethasone, and intravitreal bevacizumab)
    David Ehmann
    Pasqua Hospital Eye Centre, University of Saskatchewan, Regina, Sask, Canada
    Can J Ophthalmol 45:36-40. 2010
    ..We propose triple therapy consisting of verteporfin photodynamic therapy (PDT), intravitreal bevacizumab, and intravitreal dexamethasone...
  99. ncbi IGF signaling pathway as a selective target of familial breast cancer therapy
    Vivek Shukla
    Genetics of Development and Disease Branch, 10 9N105, Diabetes Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Mol Med 8:727-40. 2008
    ..Here, we will examine our understanding of the functions of IGF/IGF-receptor signaling, the development of new inhibitors of this pathway and the related mechanisms of familial breast cancer formation...
  100. pmc Bilirubin oxidation products, oxidative stress, and intracerebral hemorrhage
    J F Clark
    Department of Neurology, University of Cincinnati, Cincinnati, OH 45267 0536, USA
    Acta Neurochir Suppl 105:7-12. 2008
    ..Oxidation of unconjugated bilirubin to yield bioactive molecules, such as BOXes, is an important discovery, expanding the role of bilirubin in pathological processes seen after ICH...
  101. ncbi A comparative study of ectonucleotidase and P2 receptor mRNA profiles in C6 cell line cultures and C6 ex vivo glioma model
    Elizandra Braganhol
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, UFRGS, Rua Ramiro Barcelos 2600 anexo, CEP 90035 003 Porto Alegre, RS, Brazil
    Cell Tissue Res 335:331-40. 2009
    ..Thus, the disruption of purinergic signalling is a feature shown not only by glioma cell lineages, but also by primary glioma cultures. Our results therefore suggest the participation of the purinergic system in glioma malignancy...

Research Grants68

  1. Cross-talk Between Coagulation, Inflammation, and Immunity
    Lawrence L Leung; Fiscal Year: 2013
    ..We believe that this crosstalk between blood clotting, inflammation and immunity is important and highly relevant to our understanding of many diseases including cancer, inflammatory diseases, and abnormal blood clotting. ..
  2. Mechanisms of hepcidin effects in the anemia of chronic disease
    Robert T Means; Fiscal Year: 2013
    ..ACD has generally been considered to result from a combination of pathologic processes which can be linked to the cytokine mediators of inflammation...
  3. Cellular &Molecular Defects in Human B Cell Development
    Charlotte Cunningham-Rundles; Fiscal Year: 2013
    ..We hypothesize that mutations in this receptor and its isoforms can be used to elucidate the complex functions of this receptor in a human system. ..
    Alex Brown; Fiscal Year: 2010
    ..acid is metabolized to leukotrienes and prostaglandins that have well established roles in physiologic and pathologic processes such as renal perfusion, gastric cytoprotection, hemostasis, cancer, host defense, inflammation, and asthma...
  5. Molecular physiology of voltage-gated Ca2+ channels
    Jian Yang; Fiscal Year: 2013
    ..By studying a novel form of activity-dependent fragmentation of VGCCs on the cell membrane, this work may lead to a better understanding of VGCC function and regulation in physiological and pathological conditions. ..
  6. Identifying Key Structural Elements in the Activation of the Arp2/3 Complex
    Patricia A Khuu; Fiscal Year: 2013
    ..Arp2/3 is also involved in metastasis as it is required in the formation of cellular structures such as lamellipodia of migrating cells and invadopodia of cancers cells [5, 6]. ..
    SHELLY CHI LOO LU; Fiscal Year: 2013
  8. Targeting Galectin-1 with radiation in lung cancer
    QUYNH THU XUAN LE; Fiscal Year: 2013
    ..Gal-1 has been implicated in several pathologic processes including tumor proliferation, aggregation, adhesion, migration, angiogenesis and enhancing T-cell ..
    Keiko Hirose; Fiscal Year: 2013
    ..We will use methods to suppress monocytes and macrophages, important cellular components of inflammation, to determine how these cells affect injury in the inner ear after exposure to ototoxic medications. ..
  10. Developing a New Antioxidant Activator to Intervene in Lung Inflammatory Diseases
    JOHN WILLIMANN; Fiscal Year: 2009
    ..Antioxidants synthesized in lung tissues are known to offer protection against pathologic processes associated with many of these diseases...
  11. Structure and function of chloride channels and transporters
    Alessio Accardi; Fiscal Year: 2013
    ..unreadable][unreadable] ..
  12. Inner Ear Impact of Chronic Middle Ear Inflammation
    DENNIS ROYAL TRUNE; Fiscal Year: 2013
    ..of inner ear gene expression due to acute and chronic middle ear inflammation and assess how these pathologic processes can be controlled by targeted therapies...
  13. Neurotrophic Factors: Genetic Variation and Serum Levels in Brain Aging
    Sudha Seshadri; Fiscal Year: 2010
  14. Seahorse XF96 Extracellular Flux Analyzer
    Enrique Saez; Fiscal Year: 2013
  15. Molecular Regulation of Vascular Regression
    Roberto Nicosia; Fiscal Year: 2013
    ..the formation of new blood vessels, plays a critical role in the progression of cancer and other pathologic processes, but it also ameliorates coronary artery disease and other ischemic conditions caused by inadequate ..
  16. WNT and gonadotropin mediated regulation of ovarian steroidogenesis
  17. Coordination of Pathophysiologic Endothelial Cell Signaling by ROS
    Madesh Muniswamy; Fiscal Year: 2012
  18. Regulation and Function of the Matricellular Protein CCN1 in Ischemic Retinopathy
    Brahim Chaqour; Fiscal Year: 2013
    ..This proposal will provide new insights into the molecular mechanisms of CCN1 activities in vivo and may foster future safer, less destructive, and more effective therapies to harness ischemia-induced neovascularization in ROP. ..
  19. Role of Protein Kinase D in Skin Epithelia
    Soosan Ghazizadeh; Fiscal Year: 2012
  20. Predicting Cognitive Decline in Adults with Down Syndrome
    Ira T Lott; Fiscal Year: 2013
    ..This proposal is consistent with the mission of NICHD in directing attention towards the prevention of disease and disability in a population with a common developmental disorder. ..
  21. Role of microRNAs in lipid metabolism and cardiovascular disease
    Carlos Fernandez Hernando; Fiscal Year: 2013
  22. Signaling Connections Controlling Cell Motility and Invasion
    David D Schlaepfer; Fiscal Year: 2013
    ..This multi-faceted approach will yield a comprehensive understanding of Rgnef-FAK signaling axis within fibroblasts and ovarian cancer cells and provide new insights into pathways driving disease progression. ..
  23. Biomarkers of Kidney Pathology
    Sushrut S Waikar; Fiscal Year: 2013
    ..Urine, plasma, and DNA samples will be shared with the Consortium for future studies. ..
  24. Genetic Regulation of Metabolic and Fibrotic Programs in Hypertrophic Heart
    M A Q Siddiqui; Fiscal Year: 2013
  25. The role and biology of Fra-1 in lung injury and repair
    Sekhar P Reddy; Fiscal Year: 2013 activated by environmental insults and regulates gene expression that is involved in both normal and pathologic processes. During the last funding period, we have shown that interplay between the upstream promoter elements and ..
  26. The Roles of Semaphorin Signaling During Valvuloseptal Development
    Kai Jiao; Fiscal Year: 2013
  27. Monocyte microRNA155 and atherosclerosis
    Daping Fan; Fiscal Year: 2012
    ..We will also explore the underlying molecular mechanism. ..
  28. Developing A Novel Therapy for Diabetic Retinopathy
    Danyang Chen; Fiscal Year: 2013
    ..The proposed studies will lay a solid groundwork for future Phase II preclinical studies of CLT-020 and this project may develop a more effective therapeutics to cure DR. ..
  29. The Three Rs of Immunity: Recognition, Response and Resolution
    Robert A Clark; Fiscal Year: 2010
    ..Finally, it is important to note that the work presented will be highly relevant to a wide range of pathological processes and diseases that are highly prevalent in the US and worldwide populations. ..
  30. Estrogen Receptor-Coregulator Functional Interactions
    Carolyn Louise Smith; Fiscal Year: 2012
    ..g. tissue selectivity) and pathophysiological scenarios (e.g. breast cancer), and ultimately provide new approaches for identification and characterization of ER-based therapeutics. ..
  31. Modulation of Rab7-Dependent Degradative Pathways by Novel Adenovirus Protein
    Cathleen R Carlin; Fiscal Year: 2012
    ..Altogether these studies will provide novel insights to the cell biology of membrane protein trafficking, and also the molecular basis for adenovirus-induced inflammatory disease. ..
  32. Neuroprotective agents for retinal diseases
    CHRIS LINDSEY; Fiscal Year: 2012
    ..At this time, there are no effective therapies that can restore mitochondrial function to promote photoreceptor repair/regeneration. Thus, research is needed to develop new drugs that promote mitochondrial function in the retina. ..
  33. MiR-1 is a Critical Regulator of VEGF-Induced Angiogenesis
    Seyedtaghi Takyar; Fiscal Year: 2012
  34. MiR-1 is a Critical Regulator of VEGF-Induced Angiogenesis
    Seyedtaghi Takyar; Fiscal Year: 2013
  35. Estrogen signaling transgenic mouse models
    Richard R Behringer; Fiscal Year: 2011
    ..This project will develop novel estrogen receptor transgenic mouse models to activate estrogen-regulated gene expression in different organs to study the diverse physiological and pathological processes controlled by estrogen. ..
  36. Interleukin-18 and post infarct myocardial remodeling
    Bysani Chandrasekar; Fiscal Year: 2013
    ..The primary goal of this proposal is to better understand the role of inflammatory cytokines, interleukin-18 in particular, in post-infarct myocardial injury, remodeling and failure. ..
  37. Human serum carbonyl proteome in cardiovascular diseases
    Nisha Jain Garg; Fiscal Year: 2010
    ..These studies will yield potential targets for the development of new drug therapies. ..
  38. The connection between Notch signaling and VEGFR1 in angiogenesis
    HASINA HAMILTON OUTTZ; Fiscal Year: 2011
  39. GST alleles and oxidant pollutants in the pathogenesis of asthma
    Beverly H Koller; Fiscal Year: 2010
    ..Inhaled pollutants can contribute to the risk for development of lung disease through a number of pathologic processes, including inflammation of the airways...
  40. Role of Beta 1 containing Integrins in Cutaneous Basement Membrane Organization
    Srikala Raghavan; Fiscal Year: 2010
  41. Cutaneous wound remodeling by re-differentiating keratinocytes expressing CXCR3 l
    ARTHUR HUEN; Fiscal Year: 2013
    ..Well's laboratory studies molecular mechanisms regulating cellular migration in both physiologic and pathologic processes such as wound healing and tumor invasion, respectively...
  42. Mechanisms of Acceptance in Mouse Renal Allografts
    Robert B Colvin; Fiscal Year: 2013
  43. Atrogin-1 and Muscle Protein Balance
    Stewart H Lecker; Fiscal Year: 2010
    ..These studies of atrogin-1 function will help elucidate how the body regulates muscle size, and will ultimately lead to development of drugs to combat muscle wasting. ..
  44. Measurement of Beta Cell Death in Diabetes
    Kevan C Herold; Fiscal Year: 2012
    ..the course of T1D but the effective application of these therapies requires a clearer understanding of the pathologic processes including the timing and precipitants of [unreadable] cell death because these therapies have not led to ..
  45. p38 MAPK a regulator of muscle contraction and function
    Zhen Yan; Fiscal Year: 2013
  46. Circadian Repressors Cry1 and Cry2 Modulate Nuclear Hormone Receptor Function
    Katja A Lamia; Fiscal Year: 2013
    ..This project involves the study of a novel regulator for nuclear hormone receptor function and will contribute to the knowledge base needed for the development of therapeutic strategies to treat metabolic disease. ..
  47. Creation of adult epithelial stem cells from differentiated epithelial
    Robert A Weinberg; Fiscal Year: 2010
    ..We believe that this strategy can be applied to many epithelial tissues, such as the skin or mouth mucosa. ..
  48. Features of chronic tinnitus in an animal model as indicated by MEMRI and MRS
    BORIS M ODINTSOV; Fiscal Year: 2012
    ..The benefit of the proposed studies is that they will identify brain areas and pathological processes that may then be targeted for therapeutic intervention. ..
  49. 2012 Thiol-based Redox Regulation &Signaling GRC and GRS
    Leslie B Poole; Fiscal Year: 2011
  50. Apoptosis and Necrosis in Pancreatitis
    Anna S Gukovskaya; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The pathologic processes that initiate and perpetuate acute pancreatitis remain unclear. A recognized feature of this disease is the accumulation of vacuoles in acinar cells...
  51. Role of Prion Protein in Manganese Neurotoxicity
    ..Together, results from the proposed studies will not only provide new insights into the role of prion protein in manganese neurotoxicity but also will advance understanding of the role of metals in the pathogenesis of prion diseases. ..
  52. The Role of miRNAs in Epithelial-Mesenchymal Transition and Metastasis
    Yibin Kang; Fiscal Year: 2013
    Frank D Gilliland; Fiscal Year: 2013
  54. Circadian rhythms and melatonin signaling in the aging gastrointestinal system
    Vincent M Cassone; Fiscal Year: 2013
  55. Mechanisms of Protein Kinase Activation by Ubiquitin in the NF-kB Pathways
    Zhijian J Chen; Fiscal Year: 2013
    ..If successful, our research should reveal the fundamental mechanisms of NF-kB activation in immune and inflammatory responses and provide potential new approaches to inhibit aberrant NF-kB activation in human diseases. ..
  56. Dysregulated Hypothalamic-pituitary-adrenal Axis During Biliary Hyperplasia
    Sharon Demorrow; Fiscal Year: 2013
    ..This knowledge may play a paramount role in the development of therapeutic strategies for the treatment of cholangiopathies. ..
  57. Transmissibility of Neurodegenerative Diseases
    DMITRY Y GOLDGABER; Fiscal Year: 2011
    ..It will also open new approaches and new opportunities in studying the pathological processes and in the development of new treatments of neurodegenerative diseases. ..
  58. Admixture Mapping of Preterm Birth Genes
    Jerome F Strauss; Fiscal Year: 2013
    ..Finally, genetic markers could refine understanding of the normal as well as pathologic processes underlying parturition, and lead to innovative medical treatments based on contributing genes...
  59. Study the roles of RNA editing enzyme ADAR1 in the regulation of cell death
    Qingde Wang; Fiscal Year: 2010
    ..the research of ADAR1 is to define its function and mechanism in order to therapeutically target ADAR1 in pathologic processes. Our preliminary data has shown that ADAR1 directly interacts with the NF-kB pathway and up-regulates NF-kB ..
  60. Hybridization Chain Reaction: In Situ Amplification for Biological Imaging
    Niles A Pierce; Fiscal Year: 2013
    ..abstract_text> ..
  61. Regulation & Function of Calponin
    Jian Ping Jin; Fiscal Year: 2010
    ..The results will provide new insights into many important physiological and pathological processes, such as cell proliferation, cell migration, wound healing, myogenesis, lung alveolar mechanics, and tumor metastasis. ..
  62. The role of interleukin-18 in myocardial hypertrophy and failure
    Bysani Chandrasekar; Fiscal Year: 2013
    ..The primary goal of this proposal is to better understand the role of inflammatory cytokines, interleukin-18 in particular, in myocardial hypertrophy and its transition to failure. ..
  63. Chemistry of Reactive Intermediates Generated from Benzothiazole Derived Drug Can
    Michael Novak; Fiscal Year: 2009
    ..This proposed study of the chemistry of these metabolites will make it possible to understand how these compounds function in their biological roles and may ultimately lead to the design of better drug candidates. ..
  64. Algorithms and Image Analysis Software Tool for Automated Recognition and Identif
    JELENA KOVACEVIC; Fiscal Year: 2010
  65. Olympus NanoZoomer RS Whole Slide Imaging System
    Brendan F Boyce; Fiscal Year: 2010
    ..assessment of paraffin-embedded H&E-stained sections on glass slides to distinguish normal from pathologic processes, followed by analysis of further sections stained with special histochemical or immunohistochemical (IHC) ..
    John Wright; Fiscal Year: 1993
    ..The long range goal of this project is to understand the normal and pathological development of human enamel and to definitively delineate the different AI types...
    Douglas Ross; Fiscal Year: 1992
    JEFFREY DAVIDSON; Fiscal Year: 1999