atrophy

Summary

Summary: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.

Top Publications

  1. ncbi A voxel-based morphometric study of ageing in 465 normal adult human brains
    C D Good
    Wellcome Department of Cognitive Neurology, Institute of Neurology, London, United Kingdom
    Neuroimage 14:21-36. 2001
  2. ncbi Accurate, robust, and automated longitudinal and cross-sectional brain change analysis
    Stephen M Smith
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, FMRIB, University of Oxford, John Radcliffe Hospital, Headley Way, Headington, Oxford, United Kingdom
    Neuroimage 17:479-89. 2002
  3. doi Regional brain atrophy and functional disconnection across Alzheimer's disease evolution
    T Gili
    MARBILab, Enrico Fermi Centre, Rome, Italy
    J Neurol Neurosurg Psychiatry 82:58-66. 2011
  4. pmc Disability, atrophy and cortical reorganization following spinal cord injury
    Patrick Freund
    Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK
    Brain 134:1610-22. 2011
  5. pmc Longitudinal MRI atrophy biomarkers: relationship to conversion in the ADNI cohort
    Shannon L Risacher
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University, School of Medicine, 950 W Walnut St, Indianapolis, IN 46202, United States
    Neurobiol Aging 31:1401-18. 2010
  6. pmc Association of retinal and macular damage with brain atrophy in multiple sclerosis
    Jan Dorr
    NeuroCure Clinical Research Center, Charite Universitaetsmedizin Berlin, Berlin, Germany
    PLoS ONE 6:e18132. 2011
  7. pmc Regional brain stem atrophy in idiopathic Parkinson's disease detected by anatomical MRI
    Thomas Jubault
    Unité de Neuroimagerie Fonctionelle, Institut Universitaire de Geriatrie de Montreal, Montreal, Quebec, Canada
    PLoS ONE 4:e8247. 2009
  8. ncbi A voxel-based morphometry study of patterns of brain atrophy in ALS and ALS/FTLD
    J L Chang
    Department of Neurology, University of California San Francisco, CA, USA
    Neurology 65:75-80. 2005
  9. pmc Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial
    A David Smith
    Oxford Project to Investigate Memory and Ageing, University of Oxford, Oxford, United Kingdom
    PLoS ONE 5:e12244. 2010
  10. pmc Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease
    C R Jack
    Department of Diagnostic Radiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Neurology 49:786-94. 1997

Detail Information

Publications249 found, 100 shown here

  1. ncbi A voxel-based morphometric study of ageing in 465 normal adult human brains
    C D Good
    Wellcome Department of Cognitive Neurology, Institute of Neurology, London, United Kingdom
    Neuroimage 14:21-36. 2001
    ..There was no interaction of age with sex for regionally specific effects. These results corroborate previous reports and indicate that VBM is a useful technique for studying structural brain correlates of ageing through life in humans...
  2. ncbi Accurate, robust, and automated longitudinal and cross-sectional brain change analysis
    Stephen M Smith
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, FMRIB, University of Oxford, John Radcliffe Hospital, Headley Way, Headington, Oxford, United Kingdom
    Neuroimage 17:479-89. 2002
    Quantitative measurement of brain size, shape, and temporal change (for example, in order to estimate atrophy) is increasingly important in biomedical image analysis applications...
  3. doi Regional brain atrophy and functional disconnection across Alzheimer's disease evolution
    T Gili
    MARBILab, Enrico Fermi Centre, Rome, Italy
    J Neurol Neurosurg Psychiatry 82:58-66. 2011
    To assess the contribution of regional grey matter (GM) atrophy and functional disconnection in determining the level of cognitive decline in patients with Alzheimer's disease (AD) at different clinical stages.
  4. pmc Disability, atrophy and cortical reorganization following spinal cord injury
    Patrick Freund
    Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK
    Brain 134:1610-22. 2011
    ..In conclusion, spinal cord injury leads to cord atrophy, cortical atrophy of primary motor and sensory cortex, and cortical reorganization of the sensorimotor system...
  5. pmc Longitudinal MRI atrophy biomarkers: relationship to conversion in the ADNI cohort
    Shannon L Risacher
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University, School of Medicine, 950 W Walnut St, Indianapolis, IN 46202, United States
    Neurobiol Aging 31:1401-18. 2010
    ..We analyzed magnetic resonance imaging (MRI) atrophy rate from baseline to 1 year in 4 groups of participants from the Alzheimer's Disease Neuroimaging Initiative (..
  6. pmc Association of retinal and macular damage with brain atrophy in multiple sclerosis
    Jan Dorr
    NeuroCure Clinical Research Center, Charite Universitaetsmedizin Berlin, Berlin, Germany
    PLoS ONE 6:e18132. 2011
    ..However, crucial aspects including the association between OCT- and MRI-based atrophy measures or the impact of MS-related parameters on OCT parameters are still unclear...
  7. pmc Regional brain stem atrophy in idiopathic Parkinson's disease detected by anatomical MRI
    Thomas Jubault
    Unité de Neuroimagerie Fonctionelle, Institut Universitaire de Geriatrie de Montreal, Montreal, Quebec, Canada
    PLoS ONE 4:e8247. 2009
    ..This damage could also explain some non-motor symptoms in PD that often precede diagnosis, such as autonomic dysfunction and sleep disorders...
  8. ncbi A voxel-based morphometry study of patterns of brain atrophy in ALS and ALS/FTLD
    J L Chang
    Department of Neurology, University of California San Francisco, CA, USA
    Neurology 65:75-80. 2005
    To investigate the patterns of MRI brain atrophy in patients with ALS with and without clinically evident frontotemporal lobar dementia (FTLD) using voxel-based morphometry (VBM).
  9. pmc Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial
    A David Smith
    Oxford Project to Investigate Memory and Ageing, University of Oxford, Oxford, United Kingdom
    PLoS ONE 5:e12244. 2010
    An increased rate of brain atrophy is often observed in older subjects, in particular those who suffer from cognitive decline. Homocysteine is a risk factor for brain atrophy, cognitive impairment and dementia...
  10. pmc Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease
    C R Jack
    Department of Diagnostic Radiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Neurology 49:786-94. 1997
    ..99 SD, and moderate AD (CDR 2) -2.22 SD. Age- and gender-adjusted, normalized MRI-based hippocampal volumetric measurements provide a sensitive marker of the MTL neuroanatomic degeneration in AD early in the disease process...
  11. pmc Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer's disease
    Clifford R Jack
    Department of Radiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Brain 133:3336-48. 2010
    ..Our objective was to evaluate the ability of Aβ load and neurodegenerative atrophy on magnetic resonance imaging to predict shorter time-to-progression from mild cognitive impairment to Alzheimer'..
  12. pmc Inflammation, atrophy, and gastric cancer
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Invest 117:60-9. 2007
    ..population and is now known to be responsible for inducing chronic gastric inflammation that progresses to atrophy, metaplasia, dysplasia, and gastric cancer...
  13. ncbi Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: involvement of glucocorticoid secretion and excitatory amino acid receptors
    A M Magarinos
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    Neuroscience 69:89-98. 1995
    Repeated restraint stress of rats for 21 days causes atrophy of apical dendrites of hippocampal CA3c pyramidal neurons...
  14. ncbi Thalamic atrophy and cognition in multiple sclerosis
    M K Houtchens
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Partners MS Center, Boston, MA 02115, USA
    Neurology 69:1213-23. 2007
    Recent studies have indicated that brain atrophy is more closely associated with cognitive impairment in multiple sclerosis (MS) than are conventional MRI lesion measures...
  15. doi PI3 kinase regulation of skeletal muscle hypertrophy and atrophy
    David J Glass
    Novartis Institute for Biomedical Research, Cambridge, MA 02139, USA
    Curr Top Microbiol Immunol 346:267-78. 2010
    ..that can induce protein synthesis and block the transcriptional upregulation of key mediators of skeletal muscle atrophy, the E3 ubiquitin ligases MuRF1 and MAFbx (also called Atrogin-1), by phosphorylating and thereby inhibiting the ..
  16. ncbi MRI volumetry of the thalamus in temporal, extratemporal, and idiopathic generalized epilepsy
    Jun Natsume
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute and Hospital, Quebec, Canada
    Neurology 60:1296-300. 2003
    To examine the specificity of thalamic atrophy in epilepsy.
  17. pmc Spatial patterns of brain atrophy in MCI patients, identified via high-dimensional pattern classification, predict subsequent cognitive decline
    Yong Fan
    Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Neuroimage 39:1731-43. 2008
    Spatial patterns of brain atrophy in mild cognitive impairment (MCI) and Alzheimer's disease (AD) were measured via methods of computational neuroanatomy. These patterns were spatially complex and involved many brain regions...
  18. doi Cortical lesions and atrophy associated with cognitive impairment in relapsing-remitting multiple sclerosis
    Massimiliano Calabrese
    Multiple Sclerosis Centre of Veneto Region, First Neurology Clinic, Department of Neurosciences, University Hospital of Padua
    Arch Neurol 66:1144-50. 2009
    ..Double inversion recovery sequences allow cortical lesions (CLs) to be detected in the brain of patients with MS. Modern postprocessing techniques allow cortical atrophy to be assessed reliably.
  19. doi Gray matter atrophy in multiple sclerosis: a longitudinal study
    Elizabeth Fisher
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Ann Neurol 64:255-65. 2008
    To determine gray matter (GM) atrophy rates in multiple sclerosis (MS) patients at all stages of disease, and to identify predictors and clinical correlates of GM atrophy.
  20. ncbi Clinical, genetic, and neuropathologic characteristics of posterior cortical atrophy
    D F Tang-Wai
    Department of Neurology, Mayo Alzheimer s Disease Research Center, Rochester, MN, USA
    Neurology 63:1168-74. 2004
    To examine the clinical, genetic, and neuropathologic features of posterior cortical atrophy (PCA).
  21. pmc Robust atrophy rate measurement in Alzheimer's disease using multi-site serial MRI: tissue-specific intensity normalization and parameter selection
    Kelvin K Leung
    Dementia Research Centre DRC, Institute of Neurology, University College London, London, UK
    Neuroimage 50:516-23. 2010
    We describe an improved method of measuring brain atrophy rates from serial MRI for multi-site imaging studies of Alzheimer's disease (AD)...
  22. pmc Age-related cerebral atrophy in nonhuman primates predicts cognitive impairments
    Jean Luc Picq
    Laboratoire de psychopathologie et de neuropsychologie, EA, 2027, Université Paris 8, 2 rue de la liberté, 93000 St Denis, France
    Neurobiol Aging 33:1096-109. 2012
    ..not in nonhuman primates, a clear relationship has been established between age-associated cognitive decline and atrophy of specific brain regions...
  23. pmc One-year brain atrophy evident in healthy aging
    Anders M Fjell
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, 0317 Oslo, Norway
    J Neurosci 29:15223-31. 2009
    ..Some of the atrophy occurred in areas vulnerable to AD, while other changes were observed in areas less characteristic of the disease ..
  24. pmc Alzheimer's disease pattern of brain atrophy predicts cognitive decline in Parkinson's disease
    Daniel Weintraub
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 3339, USA
    Brain 135:170-80. 2012
    ..To assess the clinical significance of this, we applied a validated Alzheimer's disease-spatial pattern of brain atrophy to patients with Parkinson's disease with a range of cognitive abilities to determine its association with ..
  25. pmc Depressive symptoms in mild cognitive impairment predict greater atrophy in Alzheimer's disease-related regions
    Grace J Lee
    Department of Neurology, David Geffen School of Medicine at University of California Los Angeles, USA
    Biol Psychiatry 71:814-21. 2012
    ..Thus, we examined the neuroanatomical changes associated with depressive symptoms in MCI...
  26. doi Age-related choroidal atrophy
    Richard F Spaide
    Vitreous Retina Macula Consultants of New York and the LuEsther T Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York 10022, USA
    Am J Ophthalmol 147:801-10. 2009
    To report the clinical characteristics of a newly defined entity, age-related choroidal atrophy.
  27. pmc Intellectual enrichment lessens the effect of brain atrophy on learning and memory in multiple sclerosis
    James F Sumowski
    Neuropsychology and Neuroscience Laboratory, Kessler Foundation Research Center, Suite 10, West Orange, NJ 07052, USA
    Neurology 74:1942-5. 2010
    ..with multiple sclerosis (MS); however, such deficits are only weakly associated with MS disease severity (brain atrophy)...
  28. ncbi Whole-brain and regional brain atrophy in amyotrophic lateral sclerosis
    D M Mezzapesa
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    AJNR Am J Neuroradiol 28:255-9. 2007
    ..Our purpose was to obtain measures of global and regional atrophy in nondemented patients with ALS to assess subtle structural brain changes.
  29. doi Basal ganglia, thalamus and neocortical atrophy predicting slowed cognitive processing in multiple sclerosis
    Sônia Batista
    Department of Neurology, Coimbra University Hospitals, Coimbra, Portugal
    J Neurol 259:139-46. 2012
    ..To determine if basal ganglia and thalamus atrophy independently contribute to visual and auditory IPS impairment in MS, after controlling for the influence of ..
  30. doi The pattern of cortical atrophy in patients with Parkinson's disease according to cognitive status
    Sook K Song
    Department of Neurology, Jeju University College of Medicine, Jeju, Korea
    Mov Disord 26:289-96. 2011
    ..Cognitive dysfunction is common in Parkinson's disease (PD), and along with PD with dementia (PDD), the concept of mild cognitive impairment in PD (PD-MCI) has been introduced...
  31. ncbi Focal cortical presentations of Alzheimer's disease
    S Alladi
    Department of Clinical Neurosciences, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Brain 130:2636-45. 2007
    ..AD) pathology in patients presenting with progressive focal cortical syndromes, notably posterior cortical atrophy (PCA), corticobasal syndrome (CBS), behavioural variant frontotemporal dementia (bvFTD), progressive non-fluent ..
  32. ncbi Direct voxel-based comparison between grey matter hypometabolism and atrophy in Alzheimer's disease
    G Chetelat
    Inserm EPHE Universite de Caen Basse Normandie, Unité E0218 U923, Laboratoire de Neuropsychologie, GIP Cyceron, CHU Cote de Nacre, Caen, France
    Brain 131:60-71. 2008
    ..disease are being refined and discrepancies between them are being underlined, the exact relationships between atrophy and hypometabolism are still unclear...
  33. pmc Cerebral tissue repair and atrophy after embolic stroke in rat: a magnetic resonance imaging study of erythropoietin therapy
    Guangliang Ding
    Department of Neurology, Henry Ford Hospital, Detroit, MI 48202, USA
    J Neurosci Res 88:3206-14. 2010
    ..increased after EPO treatment compared with control animals, indicating that EPO significantly reduces atrophy of the ipsilateral hemisphere, although no significant differences in ischemic lesion volume were observed ..
  34. pmc Cardiorespiratory fitness and brain atrophy in early Alzheimer disease
    J M Burns
    Department of Neurology, Hoglund Brain Imaging Center, University of Kansas School of Medicine, 3599 Rainbow Blvd, MSN 2012, Kansas City, KS 66160, USA
    Neurology 71:210-6. 2008
    To examine the correlation of cardiorespiratory fitness with brain atrophy and cognition in early-stage Alzheimer disease (AD).
  35. pmc Hypertrophic cardiomyopathy in high-fat diet-induced obesity: role of suppression of forkhead transcription factor and atrophy gene transcription
    Cindy X Fang
    Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA
    Am J Physiol Heart Circ Physiol 295:H1206-H1215. 2008
    ..Foxo transcription factors initiate an atrophy-related gene program to counter hypertrophic growth...
  36. ncbi Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy
    George J Francis
    Department of Clinical Neurosciences and the Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    Brain 131:3311-34. 2008
    Insulin deficiency in type I diabetes may lead to cognitive impairment, cerebral atrophy and white matter abnormalities...
  37. pmc Brain atrophy correlates with functional outcome in a murine model of multiple sclerosis
    I Pirko
    Mayo Clinic, Department of Neurology, College of Medicine, Rochester, MN 55905, USA
    Neuroimage 54:802-6. 2011
    ..Unlike lesion based measures, volumetric MRI assessment of brain atrophy shows a strong correlation with functional outcome, and the presence of early atrophy predicts a worse disease ..
  38. ncbi Differential regional atrophy of the cingulate gyrus in Alzheimer disease: a volumetric MRI study
    Bethany F Jones
    Department of Neurology, VU University Medical Centre, Amsterdam, The Netherlands
    Cereb Cortex 16:1701-8. 2006
    ..imaging-based volumetric measurements provide a useful technique for quantifying in vivo regional cerebral atrophy in Alzheimer disease (AD)...
  39. pmc Baseline MRI predictors of conversion from MCI to probable AD in the ADNI cohort
    Shannon L Risacher
    IU Center for Neuroimaging, Division of Imaging Sciences, Department of Radiology, Indiana University School of Medicine, 950 W Walnut St, R2 E124, Indianapolis, IN 46202, USA
    Curr Alzheimer Res 6:347-61. 2009
    ..Validation of imaging biomarkers is important as they can help enrich clinical trials of disease modifying agents by identifying individuals at highest risk for progression to AD...
  40. ncbi A longitudinal study of brain volume changes in normal aging using serial registered magnetic resonance imaging
    Rachael I Scahill
    Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, University College London, England
    Arch Neurol 60:989-94. 2003
    To investigate the effect of age on global and regional brain volumes and rates of atrophy, and to compare directly results based on cross-sectional and longitudinal data.
  41. pmc Baseline and longitudinal patterns of brain atrophy in MCI patients, and their use in prediction of short-term conversion to AD: results from ADNI
    Chandan Misra
    Department of Radiology, Section of Biomedical Image Analysis, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Neuroimage 44:1415-22. 2009
    ..whereas they were positive in almost all MCI converters (MCI-C), indicating extensive patterns of AD-like brain atrophy in almost all MCI-C. Both MCI subgroups had similar MMSE scores at baseline...
  42. pmc Atrophy patterns in histologic vs clinical groupings of frontotemporal lobar degeneration
    J M S Pereira
    Department of Clinical Neurosciences, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Neurology 72:1653-60. 2009
    Predictable patterns of atrophy are associated with the clinical subtypes of frontotemporal dementia (FTD): behavioral variant (bvFTD), semantic dementia (SEMD), and progressive nonfluent aphasia (PNFA)...
  43. ncbi Distribution of grey matter atrophy in Huntington's disease patients: a combined ROI-based and voxel-based morphometric study
    G Douaud
    URA CNRS CEA 2210, Service Hospitalier Frederic Joliot, 4, place du General Leclerc, 91 401 Orsay, and Département de Neurologie, CHU Angers, France
    Neuroimage 32:1562-75. 2006
    ..The measurement of striatal atrophy using the bicaudate ratio on CT scanner images has therefore been used for years to assess disease progression, ..
  44. pmc Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease
    Clifford R Jack
    Clifford R Jack, Mayo Clinic, Diagnostic Radiology, 200 First Street SW, Rochester, MN 55905, USA
    Brain 132:1355-65. 2009
    ..PIB retention was quantified in global cortical to cerebellar ratio units and brain atrophy in units of cm(3) by measuring ventricular expansion...
  45. doi Issues with threshold masking in voxel-based morphometry of atrophied brains
    Gerard R Ridgway
    Centre for Medical Image Computing CMIC, Department of Medical Physics and Bioengineering, University College London, WC1E 6BT, London, UK
    Neuroimage 44:99-111. 2009
    ..risk of excluding from the analysis precisely those voxels where the subjects' brains were most vulnerable to atrophy. We investigate the issues related to mask construction, and recommend the use of alternative strategies which ..
  46. doi Hippocampal volume and asymmetry in mild cognitive impairment and Alzheimer's disease: Meta-analyses of MRI studies
    Feng Shi
    National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China
    Hippocampus 19:1055-64. 2009
    ..In this article, meta-analyses are designed to determine the extent of hippocampal atrophy in MCI and AD, and to evaluate the asymmetry pattern of the hippocampal volume in control, MCI, and AD groups...
  47. ncbi Normalized accurate measurement of longitudinal brain change
    S M Smith
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, England
    J Comput Assist Tomogr 25:466-75. 2001
    Quantitative measurement of change in brain size and shape (e.g., to estimate atrophy) is an important current area of research. New methods of change analysis attempt to improve robustness, accuracy, and extent of automation...
  48. ncbi Cyclooxygenase-2 is up-regulated in proliferative inflammatory atrophy of the prostate, but not in prostate carcinoma
    S Zha
    Graduate Program of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer Res 61:8617-23. 2001
    ..tumor and normal tissue regions but was much more consistently observed in areas of proliferative inflammatory atrophy, lesions that have been implicated in prostatic carcinogenesis. Staining was also seen at times in macrophages...
  49. pmc Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy
    Jeffrey J Brault
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 285:19460-71. 2010
    ..gamma coactivator 1alpha (PGC-1alpha), like exercise, increases mitochondrial content and inhibits muscle atrophy. To understand these actions, we tested whether PGC-1alpha or its close homolog, PGC-1beta, influences muscle ..
  50. ncbi Patterns of temporal lobe atrophy in semantic dementia and Alzheimer's disease
    D Chan
    Department of Clinical Neurology, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
    Ann Neurol 49:433-42. 2001
    ..magnetic resonance imaging analyses of 30 subjects were undertaken to quantify the global and temporal lobe atrophy in semantic dementia and Alzheimer's disease...
  51. pmc 3D maps from multiple MRI illustrate changing atrophy patterns as subjects progress from mild cognitive impairment to Alzheimer's disease
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
    Brain 130:1777-86. 2007
    ..The aim of this study was to assess the progression of cerebral atrophy over multiple serial MRI during the period from aMCI to progression to AD...
  52. pmc Automated 3D mapping of hippocampal atrophy and its clinical correlates in 400 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls
    Jonathan H Morra
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
    Hum Brain Mapp 30:2766-88. 2009
    ..84; SD: 6.64). Hippocampal traces were converted to parametric surface meshes and a radial atrophy mapping technique was used to compute average surface models and local statistics of atrophy...
  53. doi Anatomically-distinct genetic associations of APOE epsilon4 allele load with regional cortical atrophy in Alzheimer's disease
    Nicola Filippini
    The Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, UK
    Neuroimage 44:724-8. 2009
    ..Our aim was to define the relationship between APOE epsilon4 allele load and regionally-specific brain cortical atrophy in Alzheimer's Disease (AD)...
  54. ncbi Brain atrophy in clinically early relapsing-remitting multiple sclerosis
    D T Chard
    NMR Research Unit, Department of Clinical Neurology, Institute of Neurology, University College London, UK
    Brain 125:327-37. 2002
    Brain atrophy measured by MRI is a potentially useful tool for monitoring disease progression in multiple sclerosis. The location, extent and mechanisms of brain atrophy in early disease are not well documented...
  55. pmc Sequential relationships between grey matter and white matter atrophy and brain metabolic abnormalities in early Alzheimer's disease
    Nicolas Villain
    Inserm EPHE Universite de Caen Basse Normandie, Unité U923, GIP Cyceron, Bd H Becquerel, BP 5229, 14074 Caen Cedex, France
    Brain 133:3301-14. 2010
    Hippocampal atrophy, posterior cingulate and frontal glucose hypometabolism, and white-matter tract disruption are well described early macroscopic events in Alzheimer's disease...
  56. doi White matter damage in Alzheimer disease and its relationship to gray matter atrophy
    Federica Agosta
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Radiology 258:853-63. 2011
    ..damage in (a) patients with probable Alzheimer disease (AD) and (b) patients with amnestic mild cognitive impairment (aMCI) and at least one abnormal biomarker and to investigate whether WM damage is related to gray matter (GM) atrophy.
  57. doi Increased brain atrophy rates in cognitively normal older adults with low cerebrospinal fluid Aβ1-42
    Jonathan M Schott
    Dementia Research Centre, University College London, Institute of Neurology, London, United Kingdom
    Ann Neurol 68:825-34. 2010
    To identify cognitively normal individuals at risk of Alzheimer disease (AD) based on cerebrospinal fluid (CSF) Aβ1-42, and to determine rates of cerebral atrophy.
  58. pmc Spatial patterns of brain amyloid-beta burden and atrophy rate associations in mild cognitive impairment
    Duygu Tosun
    Center for Imaging Neurodegenerative Diseases, Department of Veterans Affairs Medical Centre, 4150 Clement Street, Building 13, 114 M, San Francisco, CA 94121, USA
    Brain 134:1077-88. 2011
    ..decline, suggesting that events in the brain downstream from amyloid-β deposition, such as regional brain atrophy rates, play an important role...
  59. doi Posterior cingulate cortex atrophy and regional cingulum disruption in mild cognitive impairment and Alzheimer's disease
    Il Han Choo
    Department of Neuropsychiatry and Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    Neurobiol Aging 31:772-9. 2010
    This study aimed to investigate the atrophy of the posterior cingulate cortex (PCC) and medical temporal lobe (MTL) structures (i.e...
  60. ncbi Why voxel-based morphometry should be used
    J Ashburner
    The Wellcome Department of Cognitive Neurology, Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
    Neuroimage 14:1238-43. 2001
    ..We first review the tenets of VBM, paying particular attention to the relationship between VBM and tensor-based morphometry. The last two sections of this response deal with the specific concerns raised by Dr. Bookstein...
  61. ncbi Vestibular loss causes hippocampal atrophy and impaired spatial memory in humans
    Thomas Brandt
    Department of Neurology, Ludwig Maximilians University, Munich, Germany
    Brain 128:2732-41. 2005
    ..that patients (n = 10) with acquired chronic bilateral vestibular loss (BVL) develop a significant selective atrophy of the hippocampus (16.9% decrease relative to controls)...
  62. pmc Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases
    Viviana Moresi
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell 143:35-45. 2010
    ..skeletal muscle structure and function requires innervation by motor neurons, such that denervation causes muscle atrophy. We show that myogenin, an essential regulator of muscle development, controls neurogenic atrophy...
  63. pmc Plasma clusterin concentration is associated with longitudinal brain atrophy in mild cognitive impairment
    Madhav Thambisetty
    Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD 21224, USA
    Neuroimage 59:212-7. 2012
    ..effects regression models investigated whether plasma clusterin concentration was associated with rates of brain atrophy for control and MCI groups and whether these associations differed between groups...
  64. pmc Distinct profiles of brain atrophy in frontotemporal lobar degeneration caused by progranulin and tau mutations
    Jonathan D Rohrer
    Dementia Research Centre, UCL Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Neuroimage 53:1070-6. 2010
    ..Here we investigated patterns of brain atrophy produced by defined molecular lesions in the two common forms of genetically mediated frontotemporal lobar ..
  65. ncbi Neocortical atrophy, third ventricular width, and cognitive dysfunction in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, School of Medicine, State University of New York at Buffalo, 100 High Street, Buffalo, NY 14203, USA
    Arch Neurol 63:1301-6. 2006
    Cognitive dysfunction is common in multiple sclerosis (MS). Correlations are reported between atrophy and neuropsychological test results.
  66. ncbi Retinal nerve fiber layer is associated with brain atrophy in multiple sclerosis
    E Gordon-Lipkin
    Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Neurology 69:1603-9. 2007
    Optical coherence tomography (OCT) noninvasively quantifies retinal nerve fiber layer (RNFL) thickness. Studies show RNFL thinning in multiple sclerosis (MS), and we assessed its association with brain atrophy.
  67. pmc Role of intrinsic muscle atrophy in the etiology of claw toe deformity in diabetic neuropathy may not be as straightforward as widely believed
    Sicco A Bus
    Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Diabetes Care 32:1063-7. 2009
    ..in the diabetic neuropathic foot is believed to be caused by muscle imbalance resulting from intrinsic muscle atrophy. However, experimental data that support this mechanism are lacking...
  68. ncbi Assessing brain atrophy rates in a large population of untreated multiple sclerosis subtypes
    N De Stefano
    Quantitative Neuroimaging Laboratory, Department of Neurological and Behavioural Sciences, University of Siena, Italy
    Neurology 74:1868-76. 2010
    To assess the time course of brain atrophy and the difference across clinical subtypes in multiple sclerosis (MS).
  69. ncbi Whole-brain atrophy rate in Alzheimer disease: identifying fast progressors
    J D Sluimer
    Department of Radiology and Alzheimer Centre, Vrije Universiteit Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neurology 70:1836-41. 2008
    To assess which baseline clinical and MRI measures influence whole-brain atrophy rates, measured from serial MR imaging.
  70. ncbi Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid
    M Miyazaki
    Departments of Biochemistry, University of Wisconsin, Madison, 53706, USA
    J Nutr 131:2260-8. 2001
    ..These results reveal a physiologic role of SCD in cholesterol homeostasis as well as in the de novo biosynthesis of cholesterol esters, triglycerides and wax esters required for normal skin and eyelid function...
  71. pmc Mucosal atrophy in celiac disease: extent of involvement, correlation with clinical presentation, and response to treatment
    Joseph A Murray
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 6:186-93; quiz 125. 2008
    ..In this study, we evaluated the following: (1) the distribution of atrophy in untreated celiac disease, (2) the correlation between extent of changes and clinical manifestations, (3) the ..
  72. ncbi Ischemic necrosis and atrophy of the optic nerve after periocular carboplatin injection for intraocular retinoblastoma
    Ingo Schmack
    Emory Eye Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Ophthalmol 142:310-5. 2006
    ..To report four cases of optic nerve neuropathy in three children treated with periocular carboplatin injections for unilateral or bilateral intraocular retinoblastoma...
  73. ncbi Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease
    Markel Olabarria
    Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
    Glia 58:831-8. 2010
    ..42 and 32.74%). This cytoskeleton atrophy is accompanied by a significant reduction of glial somata volume in DG at 12 and 18 months (40.46 and 75...
  74. ncbi Multiple sclerosis - candidate mechanisms underlying CNS atrophy
    Volker Siffrin
    Department of Neurology, University Medicine Mainz, Johannes Gutenberg University Mainz, Germany
    Trends Neurosci 33:202-10. 2010
    ..Apart from demyelination, neuronal pathology is apparently largely responsible for the brain atrophy that can be observed early on and throughout the course of the disease...
  75. ncbi Cerebral atrophy in Parkinson's disease patients with visual hallucinations
    B Ramirez-Ruiz
    Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    Eur J Neurol 14:750-6. 2007
    ..Structural changes in these areas involved in higher visual processing may be important in understanding the VH and visual deficits in PD patients...
  76. pmc A point mutation in the dynein heavy chain gene leads to striatal atrophy and compromises neurite outgrowth of striatal neurons
    Kerstin E Braunstein
    Department of Neurology, University of Ulm, Ulm, Germany
    Hum Mol Genet 19:4385-98. 2010
    ..In vivo brain imaging using magnetic resonance imaging showed striatal atrophy and lateral ventricle enlargement...
  77. ncbi Retinal atrophy in idiopathic central serous chorioretinopathy
    Maria S M Wang
    Department of Ophthalmology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    Am J Ophthalmol 133:787-93. 2002
    To study retinal atrophy in idiopathic central serous chorioretinopathy (ICSC).
  78. ncbi MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer's disease
    B C Dickerson
    Department of Neurological Sciences, Rush University, Chicago, IL 60612, USA
    Neurobiol Aging 22:747-54. 2001
    ..from each other, as well as from controls, in hippocampal volume, with the mild AD cases showing the greatest atrophy. Follow-up clinical evaluations available on 23/28 non-demented patients indicated that 12/23 had converted to AD ..
  79. pmc Longitudinal pattern of regional brain volume change differentiates normal aging from MCI
    I Driscoll
    Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD 21224, USA
    Neurology 72:1906-13. 2009
    ..We predict that the regions that show early pathologic changes in association with Alzheimer disease will show accelerated volume loss in mild cognitive impairment (MCI) compared to normal aging...
  80. ncbi Delayed recall, hippocampal volume and Alzheimer neuropathology: findings from the Nun Study
    J A Mortimer
    Institute on Aging, University of South Florida, Tampa FL 33612 3805, USA
    Neurology 62:428-32. 2004
    ..To examine the associations of hippocampal volume and the severity of neurofibrillary lesions determined at autopsy with delayed verbal recall performance evaluated an average of 1 year prior to death...
  81. doi Optical coherence tomography in multiple sclerosis: thickness of the retinal nerve fiber layer as a potential measure of axonal loss and brain atrophy
    Malgorzata Siger
    Department of Neurology, Medical University of Lodz, Kopcinskiego 22, 90 153 Lodz, Poland
    J Neurol 255:1555-60. 2008
    ..Axonal distribution within the retinal nerve fiber layer (RNFL) measured by optical coherence tomography (OCT) correlates with axonal viability and integrity...
  82. doi The clinical profile of right temporal lobe atrophy
    Dennis Chan
    Dementia Research Centre, Department of Clinical Neurology, Institute of Neurology, London, UK
    Brain 132:1287-98. 2009
    ..and language figure prominently in two of the three variants, and are associated with left-sided frontotemporal atrophy. The detailed characterization of these syndromes contrasts with the relative paucity of information relating to ..
  83. pmc Neuropathological basis of magnetic resonance images in aging and dementia
    William J Jagust
    School of Public Health and Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720 3190, USA
    Ann Neurol 63:72-80. 2008
    ..Magnetic resonance (MR) imaging is used widely for assessment of patients with cognitive impairment, but the pathological correlates are unclear, especially when multiple pathologies are present...
  84. ncbi Hippocampus and entorhinal cortex in mild cognitive impairment and early AD
    Corina Pennanen
    Department of Neuroscience and Neurology, University of Kuopio and Brain Research Unit, Clinical Research Center, Mediteknia, P O Box 1627, FIN 70 211 Kuopio, Finland
    Neurobiol Aging 25:303-10. 2004
    ..3%) was achieved with hippocampal volumes. Our results suggest that the ERC atrophy precedes hippocampal atrophy in AD...
  85. pmc Hippocampal atrophy on MRI in frontotemporal lobar degeneration and Alzheimer's disease
    L A van de Pol
    VUMC, Department of Neurology, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 77:439-42. 2006
    Hippocampal atrophy on magnetic resonance imaging (MRI) is an early characteristic of Alzheimer's disease. However, hippocampal atrophy may also occur in other dementias, such as frontotemporal lobar degeneration (FTLD).
  86. ncbi Measurement of basal forebrain atrophy in Alzheimer's disease using MRI
    Stefan J Teipel
    Department of Psychiatry, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Dementia and Neuroimaging Section, Ludwig Maximilian University, Munich, Germany
    Brain 128:2626-44. 2005
    ..UK) to determine correlations between signal changes in the substantia innominata and cortical grey matter atrophy in the patients with Alzheimer's disease...
  87. doi Focal posterior cingulate atrophy in incipient Alzheimer's disease
    George Pengas
    University of Cambridge, Neurology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Neurobiol Aging 31:25-33. 2010
    ..studying AD patients at the mild cognitive impairment (MCI) stage, and, if so, to determine whether the amount of atrophy was comparable to that of the hippocampus...
  88. pmc TDP-43 subtypes are associated with distinct atrophy patterns in frontotemporal dementia
    J D Rohrer
    Dementia Research Centre, UCL Institute of Neurology, University College London, Queen Square, London, UK
    Neurology 75:2204-11. 2010
    ..We sought to describe the antemortem clinical and neuroimaging features among patients with frontotemporal lobar degeneration with TDP-43 immunoreactive inclusions (FTLD-TDP)...
  89. doi Three-dimensional surface mapping of hippocampal atrophy progression from MCI to AD and over normal aging as assessed using voxel-based morphometry
    G Chetelat
    Inserm EPHE Universite de Caen Basse Normandie, Unité U923, GIP Cyceron, CHU Cote de Nacre, Caen, France
    Neuropsychologia 46:1721-31. 2008
    ..recently made it possible to assess the respective involvement of the different hippocampal subfields by mapping atrophy on a 3D hippocampal surface view...
  90. ncbi Low thyroid function leads to cardiac atrophy with chamber dilatation, impaired myocardial blood flow, loss of arterioles, and severe systolic dysfunction
    Yi da Tang
    Cardiovascular Research Institute, South Dakota Health Research Foundation, University of South Dakota School of Medicine, Sioux Valley Hospitals and Health Systems, Sioux Falls, SD, USA
    Circulation 112:3122-30. 2005
    ..Although thyroid dysfunction has been linked to heart failure, it is not clear whether hypothyroidism alone can cause heart failure...
  91. doi Diet-induced obesity alters signalling pathways and induces atrophy and apoptosis in skeletal muscle in a prediabetic rat model
    Balindiwe Sishi
    Department of Physiological Sciences, Matieland, Stellenbosch 7600, South Africa
    Exp Physiol 96:179-93. 2011
    ..There is increasing evidence that TNF-α may play a critical role in skeletal muscle atrophy. However, the effects of obesity-induced insulin resistance on these signalling pathways are poorly understood in ..
  92. ncbi Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway
    Esther Latres
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591 6707, USA
    J Biol Chem 280:2737-44. 2005
    ..We first characterized molecular markers of both hypertrophy and atrophy and identified a small subset of genes that are inversely regulated in these two settings (e.g...
  93. ncbi Protective effects of vitamin A and vitamin E succinate against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced body wasting, hepatomegaly, thymic atrophy, production of reactive oxygen species and DNA damage in C57BL/6J mice
    Naser Z Alsharif
    Creighton University Medical Center, School of Pharmacy and Health Professions, Department of Pharmacy Sciences, Omaha, NE 68178, USA
    Basic Clin Pharmacol Toxicol 95:131-8. 2004
    ..05). The results indicate a potential role for oxidative stress in the acute toxicity of TCDD and a protective effect for vitamin A and vitamin E succinate in the overall toxicity of TCDD including measures of oxidative stress...
  94. pmc Temporoparietal MR imaging measures of atrophy in subjects with mild cognitive impairment that predict subsequent diagnosis of Alzheimer disease
    R S Desikan
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    AJNR Am J Neuroradiol 30:532-8. 2009
    ..Mild cognitive impairment (MCI) represents a transitional state between normal aging and Alzheimer disease (AD). Our goal was to determine if specific temporoparietal regions can predict the time to progress from MCI to AD...
  95. ncbi Medial temporal lobe atrophy on MRI predicts dementia in patients with mild cognitive impairment
    Esther S C Korf
    Department of Neurology and Alzheimer Center, Vrije Universiteit Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neurology 63:94-100. 2004
    Although detailed volumetric MRI assessment of medial temporal lobe atrophy (MTA) can predict dementia in patients with mild cognitive impairment (MCI), it is not easily applied to routine clinical practice.
  96. pmc Special article: gait measures indicate underlying focal gray matter atrophy in the brain of older adults
    Caterina Rosano
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
    J Gerontol A Biol Sci Med Sci 63:1380-8. 2008
    Our objective was to identify the spatial distribution of focal atrophy within mobility-related brain regions in relationship with quantitative gait characteristics.
  97. ncbi Vulvovaginal atrophy: current and future therapies (CME)
    Comfort Ibe
    George Washington University Medical Center Obstetrics and Gynecology, Washington, DC 20036, USA
    J Sex Med 7:1042-50; quiz 1051. 2010
    Vulvovaginal atrophy results from estrogen deficiency and affects a large number of postmenopausal women. Symptoms include vaginal dryness, itching, irritation, and dyspareunia.
  98. doi Optical coherence tomography in pediatric patients: a feasible technique for diagnosing celiac disease in children with villous atrophy
    E Masci
    Department of Gastrointestinal Endoscopy, University San Paolo Hospital, Via A Di Rudini 8, 20142 Milan, Italy
    Dig Liver Dis 41:639-43. 2009
    ..This study examined the correlation between the sensitivity and specificity of optical coherence tomography in pediatric patients undergoing esophago-gastro-duodenoscopy for the diagnosis of celiac disease...
  99. doi In vivo mapping of amyloid toxicity in Alzheimer disease
    G B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, I 25123 Brescia, Italy
    Neurology 72:1504-11. 2009
    To study the relationship between gray matter atrophy and amyloid deposition in Alzheimer disease (AD).
  100. doi The relation between person identity nodes, familiarity judgment and biographical information. Evidence from two patients with right and left anterior temporal atrophy
    Guido Gainotti
    Center for Neuropsychological Research, Department of Neurosciences of the Policlinico Gemelli Catholic University of Rome, Italy
    Brain Res 1307:103-14. 2010
    ..this study consisted of using neuropsychological data obtained in two patients (VL and StG) showing a selective atrophy of the anterior parts of the right (VL) and left (StG) temporal lobes to check current cognitive models of ..
  101. pmc Caudate atrophy on MRI is a characteristic feature of FTLD-FUS
    K A Josephs
    Department of Neurology Behavioral Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Eur J Neurol 17:969-75. 2010
    ..We have observed severe caudate atrophy at autopsy in FTLD-FUS, and hence, we aimed to determine whether caudate atrophy on MRI is a feature that can ..

Research Grants108 found, 100 shown here

  1. Non-Human Primate Model of Gluten-Sensitive Enteropathy
    Karol Sestak; Fiscal Year: 2009
    ..presence of AGA, anti-transglutaminase 2 (TG2) antibodies, villous atrophy, increased presence of IELs and inflammatory-cytokine producing intestinal T lymphocytes in macaques with ..
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Title: Pilot Study of the Evaluation of Intravitreal Sirolimus in the Treatment of Bilateral Geographic Atrophy Associated with Age-Related Macular Degeneration Number: 11-EI-0249 Summary: Background: - Age-related macular ..
  3. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
  4. Non-Human Primate Model of Gluten-Sensitive Enteropathy
    Karol Sestak; Fiscal Year: 2010
    ..presence of AGA, anti-transglutaminase 2 (TG2) antibodies, villous atrophy, increased presence of IELs and inflammatory-cytokine producing intestinal T lymphocytes in macaques with ..
  5. Non-Human Primate Model of Gluten-Sensitive Enteropathy
    Karol Sestak; Fiscal Year: 2009
    ..presence of AGA, anti-transglutaminase 2 (TG2) antibodies, villous atrophy, increased presence of IELs and inflammatory-cytokine producing intestinal T lymphocytes in macaques with ..
  6. Genetic Studies of Optic Atrophy
    Taosheng Huang; Fiscal Year: 2010
    Optic atrophy gene 1 (OPA1) is a nuclear gene encoding a mitochondrial protein. Mutation of OPA1 is the most common cause for autosomal dominant optic atrophy (DOA)...
  7. Genetic Studies of Optic Atrophy
    Taosheng Huang; Fiscal Year: 2009
    Optic atrophy gene 1 (OPA1) is a nuclear gene encoding a mitochondrial protein. Mutation of OPA1 is the most common cause for autosomal dominant optic atrophy (DOA)...
  8. Ca Signaling in Progression of Amyotrophic Lateral Sclerosis in Skeletal Muscle
    Jingsong Zhou; Fiscal Year: 2010
    ..lateral sclerosis (ALS) is a progressive neuromuscular disorder involving degeneration of motor neurons and atrophy of skeletal muscle...
  9. Molecular Pathphysiology of FSHD muscular dystrophy via genome-wide approaches
    Yi Wen Chen; Fiscal Year: 2009
    ..2007). In addition, the Pitx1 transgenic mouse model generated in aim2 showed muscle atrophy phenotype with pathology similar to FSHD...
  10. Role of 12/15-lipoxygenase in mechanisms of muscle atrophy during aging
    Arunabh Bhattacharya; Fiscal Year: 2011
    ..in San Antonio, he has been studying the role of lipid mediators generated by the inflammatory pathways in muscle atrophy, which is a new direction of research at UTHSCSA...
  11. Glucocorticoid control of gene expression during skeletal muscle atrophy
    J DAVID contact FURLOW; Fiscal Year: 2010
    ..David Skeletal muscle wasting, or atrophy, is a major human health concern...
  12. Protease regulation of ovarian recrudescence
    KELLY ANSLEY YOUNG; Fiscal Year: 2010
    ..in day length can either inhibit or stimulate hypothalamic/ pituitary secretion of GnRH/gonadotropins, leading to atrophy or resumption of ovarian function...
  13. REGULATION OF ATROPHY-INDUCED PROGENITOR CELLS IN THE GASTRIC CORPUS
    Jason C Mills; Fiscal Year: 2012
    ..Within 6 hours, parietal cells begin to die (atrophy), and progenitor cells in the isthmal stem cel niche of corpus gastric units begin to expand in response...
  14. Muscle Wasting in Uremia
    Ralph Rabkin; Fiscal Year: 2009
    ..Preliminary data indicate that disuse atrophy may be exaggerated in CKD and that recovery may be impaired...
  15. Spinal muscular atrophy: a novel role of SMN in axonal ribonucleoprotein complexe
    Wilfried Rossoll; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Spinal muscular atrophy (SMA) represents the most common genetic cause of infant mortality...
  16. EMPHYSEMA--INFLUENCES ON DIAPHRAGM FATIGUE RESISTANCE
    Michael Lewis; Fiscal Year: 1990
    ..in chronic obstructive pulmonary disease (COPD) resulting in altered diaphragmatic strength and endurance, due to atrophy of fast- twitch muscle fibers corticosteroids, which are often used in COPD, also causes as well as a decrease in ..
  17. EMPHYSEMA--INFLUENCES ON DIAPHRAGM FATIGUE RESISTANCE
    Michael Lewis; Fiscal Year: 1992
    ..in chronic obstructive pulmonary disease (COPD) resulting in altered diaphragmatic strength and endurance, due to atrophy of fast- twitch muscle fibers corticosteroids, which are often used in COPD, also causes as well as a decrease in ..
  18. Acute Nutritional Deprivation: Diaphragm Influences
    Michael Lewis; Fiscal Year: 2005
    ..improved understanding of potential molecular targets in the management of disordered protein turnover and muscle atrophy in the diaphragm of a clinically relevant animal model of severe short-term nutritional deprivation (ND)...
  19. Acute Nutritional Deprivation: Diaphragm Influences
    Michael Lewis; Fiscal Year: 2007
    ..improved understanding of potential molecular targets in the management of disordered protein turnover and muscle atrophy in the diaphragm of a clinically relevant animal model of severe short-term nutritional deprivation (ND)...
  20. Heat shock proteins and disuse muscle atrophy
    ANDREW ROBERT JUDGE; Fiscal Year: 2010
    Project summary/Abstract Skeletal muscle disuse atrophy is a widespread physiological phenomenon associated with immobilization, bed rest, denervation, and space flight, or any general reduction in weight bearing activity...
  21. Heat shock proteins and disuse muscle atrophy
    Andrew Judge; Fiscal Year: 2009
    Project summary/Abstract Skeletal muscle disuse atrophy is a widespread physiological phenomenon associated with immobilization, bed rest, denervation, and space flight, or any general reduction in weight bearing activity...
  22. Acute Nutritional Deprivation: Diaphragm Influences
    Michael Lewis; Fiscal Year: 2004
    ..improved understanding of potential molecular targets in the management of disordered protein turnover and muscle atrophy in the diaphragm of a clinically relevant animal model of severe short-term nutritional deprivation (ND)...
  23. Acute Nutritional Deprivation: Diaphragm Influences
    Michael Lewis; Fiscal Year: 2006
    ..improved understanding of potential molecular targets in the management of disordered protein turnover and muscle atrophy in the diaphragm of a clinically relevant animal model of severe short-term nutritional deprivation (ND)...
  24. HIV: Metabolic Abnormalities
    Rakhi Kohli; Fiscal Year: 2010
    ..The pathogenesis of insulin resistance in persons with central fat deposition vs. peripheral fat atrophy may differ;increased rates of lipolysis may alter fat content in the peripheral muscle and liver, leading to ..
  25. MECHANICAL VENTILATION AND RESPIRATORY MUSCLES
    Scott Powers; Fiscal Year: 2002
    ..Indeed, we have recently demonstrated that prolonged MV results in diaphragmatic atrophy and a significant reduction in diaphragmatic maximal force production...
  26. MECHANICAL VENTILATION AND RESPIRATORY MUSCLES
    Scott Powers; Fiscal Year: 2001
    ..Indeed, we have recently demonstrated that prolonged MV results in diaphragmatic atrophy and a significant reduction in diaphragmatic maximal force production...
  27. MECHANICAL VENTILATION AND RESPIRATORY MUSCLES
    Scott Powers; Fiscal Year: 2003
    ..Indeed, we have recently demonstrated that prolonged MV results in diaphragmatic atrophy and a significant reduction in diaphragmatic maximal force production...
  28. MECHANICAL VENTILATION AND RESPIRATORY MUSCLES
    Scott Powers; Fiscal Year: 2004
    ..Indeed, we have recently demonstrated that prolonged MV results in diaphragmatic atrophy and a significant reduction in diaphragmatic maximal force production...
  29. Spinal Muscular Atrophy: Is it a motor axon disease?
    Christine E Beattie; Fiscal Year: 2010
    ..Spinal muscular atrophy (SMA) is an autosomal recessive disease that causes motoneuron dysfunction leading to paralysis and in severe ..
  30. Consequences of Prolonged Febrile Seizures in Childhood
    Shlomo Shinnar; Fiscal Year: 2010
    ..the consequences of febrile status epilepticus (FSE) and will clarify the relationship between FSE, hippocampal atrophy, MTS, and subsequent epilepsy and cognitive impairment...
  31. Consequences of Prolonged Febrile Seizures in Childhood
    Shlomo Shinnar; Fiscal Year: 2010
    ..the consequences of febrile status epilepticus (FSE) and will clarify the relationship between FSE, hippocampal atrophy, MTS, and subsequent epilepsy and cognitive impairment...
  32. Consequences of Prolonged Febrile Seizures in Childhood
    Shlomo Shinnar; Fiscal Year: 2009
    ..the consequences of febrile status epilepticus (FSE) and will clarify the relationship between FSE, hippocampal atrophy, MTS, and subsequent epilepsy and cognitive impairment...
  33. Consequences of Prolonged Febrile Seizures in Childhood
    Shlomo Shinnar; Fiscal Year: 2009
    ..the consequences of febrile status epilepticus (FSE) and will clarify the relationship between FSE, hippocampal atrophy, MTS, and subsequent epilepsy and cognitive impairment...
  34. CLINICAL TRIALS FOR PEDIATRIC SPINAL MUSCULAR ATROPHY
    Susan Iannaccone; Fiscal Year: 2003
    DESCRIPTION (provided by the applicant): Spinal muscular atrophy (SMA) is a genetic disease, frequency 8 per 100,000 live births, with a high mortality during infancy and no known treatment...
  35. CLINICAL TRIALS FOR PEDIATRIC SPINAL MUSCULAR ATROPHY
    Susan Iannaccone; Fiscal Year: 2004
    DESCRIPTION (provided by the applicant): Spinal muscular atrophy (SMA) is a genetic disease, frequency 8 per 100,000 live births, with a high mortality during infancy and no known treatment...
  36. CLINICAL TRIALS FOR PEDIATRIC SPINAL MUSCULAR ATROPHY
    Susan Iannaccone; Fiscal Year: 2005
    DESCRIPTION (provided by the applicant): Spinal muscular atrophy (SMA) is a genetic disease, frequency 8 per 100,000 live births, with a high mortality during infancy and no known treatment...
  37. CRH in stress-induced hippocampal neuroplasticity
    Tallie Z Baram; Fiscal Year: 2009
    ..which results in enduring deficits of hippocampus-dependent cognitive function and LTP, together with dendritic atrophy, we found that post hoc blocking of the receptor (CRFR1) of the stress-activated neuropeptide, corticotropin ..
  38. The toxicity of the RNA CGG repeats in FXTAS
    Lubov T Timchenko; Fiscal Year: 2012
    ..Syndrome (FXTAS) is a progressive neurodegenerative disease characterized by tremor with ataxia, brain atrophy and cognitive defects...
  39. Spinal Muscular Atrophy: Cell-based drug screens for treatment of axonal defects
    Wilfried Rossoll; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Spinal muscular atrophy (SMA) is the leading genetic cause of infant mortality...
  40. Noncoding RNA targets of the spinal muscular atrophy protein
    Livio Pellizzoni; Fiscal Year: 2010
    ..recessive disorder characterized by degeneration of motor neurons in the spinal cord and skeletal muscle atrophy. SMA is the leading genetic cause of death in infancy for which no effective treatment is currently available...
  41. Noncoding RNA targets of the spinal muscular atrophy protein
    Livio Pellizzoni; Fiscal Year: 2009
    ..recessive disorder characterized by degeneration of motor neurons in the spinal cord and skeletal muscle atrophy. SMA is the leading genetic cause of death in infancy for which no effective treatment is currently available...
  42. MRI Signal Validation and Evaluation of Pathogenic Iron compounds as an Early Bio
    Christopher Batich; Fiscal Year: 2007
    ..MRI is currently being used as a diagnostic tool for AD, where both atrophy (the loss of brain cells), and senile plaques, are being imaged to assist confirmation of diagnosis...
  43. Animal models to examine role of ZPR1 protein complexes
    Laxman Gangwani; Fiscal Year: 2009
    ..of diverse human genetic diseases ranging from cancer to neurodegenerative disorders, including spinal muscular atrophy (SMA)...
  44. Animal models to examine role of ZPR1 protein complexes
    LAXMAN DASS GANGWANI; Fiscal Year: 2010
    ..of diverse human genetic diseases ranging from cancer to neurodegenerative disorders, including spinal muscular atrophy (SMA)...
  45. Musculo-Dynamics in Bone Fluid Flow, Circulation and Ada
    Yi Xian Qin; Fiscal Year: 2005
    ..g., bedrest and microgravity), have significant physiological effects in muscle atrophy and osteopenia. Exercise such as muscle contraction appears to increase blood flow to the skeletal tissues, i.e...
  46. Role of Musculo-Dynamics in Bone Fluid Flow, Circulation and Adaptation
    Yi Xian Qin; Fiscal Year: 2009
    ..g., bedrest and microgravity), have significant physiological effects in muscle atrophy and osteopenia. Exercise such as muscle contraction appears to increase blood flow to the skeletal tissues, i.e...
  47. Role of Musculo-Dynamics in Bone Fluid Flow, Circulatio*
    Yi Xian Qin; Fiscal Year: 2006
    ..g., bedrest and microgravity), have significant physiological effects in muscle atrophy and osteopenia. Exercise such as muscle contraction appears to increase blood flow to the skeletal tissues, i.e...
  48. Investigation of Gemin5 in Coordinated mRNA Regulation
    DANIEL BATTLE; Fiscal Year: 2011
    ..Gemin5 binds to snRNAs and delivers then to SMN for snRNP assembly. Mutations in SMN cause Spinal Muscular Atrophy (SMA), a common and often fatal neurodegenerative disease characterized by motor-neuron degeneration and severe ..
  49. Aging, AMP Kinase and Skeletal Muscle Overload
    Scott Gordon; Fiscal Year: 2005
    Significant skeletal muscle atrophy results in a loss of functional independence and quality of life, and interventions such as resistance exercise training are not fully effective in restoring muscle mass in elderly individuals...
  50. Molecular Mechanisms of Age-related Muscle Loss
    Christopher M Adams; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Age-related skeletal muscle atrophy is a debilitating condition that is common in veteran patients. However, it is poorly understood and lacks a therapy...
  51. Intercellular Signaling in Obstructive Nephropathy
    ROBERT CHEVALIER; Fiscal Year: 2002
    ..obstruction (UUO) are dependent on the balance between two nephron populations: those undergoing progressive atrophy, and those that maintain structural integrity and function...
  52. Intercellular Signaling in Obstructive Nephropathy
    ROBERT CHEVALIER; Fiscal Year: 2005
    ..obstruction (UUO) are dependent on the balance between two nephron populations: those undergoing progressive atrophy, and those that maintain structural integrity and function...
  53. Intercellular Signaling in Obstructive Nephropathy
    ROBERT CHEVALIER; Fiscal Year: 2003
    ..obstruction (UUO) are dependent on the balance between two nephron populations: those undergoing progressive atrophy, and those that maintain structural integrity and function...
  54. Intercellular Signaling in Obstructive Nephropathy
    ROBERT CHEVALIER; Fiscal Year: 2004
    ..obstruction (UUO) are dependent on the balance between two nephron populations: those undergoing progressive atrophy, and those that maintain structural integrity and function...
  55. GYRATE ATROPHY-MODEL FOR MOLECULAR STUDY OF EYE DISEASES
    George Inana; Fiscal Year: 1991
    ..Among the various inherited retinal degenerative diseases that lead to blindness in man, gyrate atrophy (GA) serves as a unique model because knowledge of the underlying biochemical defect, i.e...
  56. Lesion Activity and Atrophy in Multiple Sclerosis: Analysis of Multi-center MRI
    Ponnada A Narayana; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The relation between inflammatory lesions and atrophy (global, tissue-specific, and regional) that is thought to represent neurodegeneration in multiple sclerosis (MS) is of fundamental importance in ..
  57. Subconjunctival Sirolimus in the Treatment of AMD Bilateral Geographic Atrophy
    Darby Thompson; Fiscal Year: 2009
    Pilot Study of the Evaluation of Subconjunctival Sirolimus in the Treatment of Bilateral Geographic Atrophy Associated with Age-Related Macular Degeneration This study will determine if a drug called sirolimus is safe to give to people ..
  58. Tissue injury and inflammation in MS (P50)
    Richard M Ransohoff; Fiscal Year: 2010
    ..into MRI-pathology correlations;a longitudinal MRI cohort which has illuminated the mechanisms underlying brain atrophy in MS;and newly-recruited, a series of MS biopsy cases which can be studied to understand cortical pathology ..
  59. Macrostructural and Microstructural Imaging Biomarkers of Traumatic Brain Injury
    Pratik Mukherjee; Fiscal Year: 2009
    ..The macrostructural biomarker measures post- traumatic focal atrophy using deformation-based morphometry (DBM) of serial high-resolution 3D MR scans of the brain...
  60. Nemo-Like Kinase and the Pathogenesis of Spinal and Bulbar Muscular Atrophy
    TIFFANY WERLYNE TODD; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Spinal and Bulbar Muscular Atrophy (SBMA, Kennedy's Disease) is an X-linked progressive neurodegenerative disease affecting the proximal spinal and bulbar motoneurons...
  61. Impact of Exercise on Sarcopenia
    Judd M Aiken; Fiscal Year: 2010
    ..DESCRIPTION (provided by applicant): Sarcopenia, the loss of muscle mass and function due to muscle fiber loss and atrophy, is a prominent and debilitating age-related consequence in humans...
  62. Impact of Exercise on Sarcopenia
    Judd Aiken; Fiscal Year: 2009
    ..DESCRIPTION (provided by applicant): Sarcopenia, the loss of muscle mass and function due to muscle fiber loss and atrophy, is a prominent and debilitating age-related consequence in humans...
  63. Mechanical ventilation, oxidative stress, and diaphragmatic atrophy
    SCOTT KLINE POWERS; Fiscal Year: 2010
    ..Studies indicate that MV-induced diaphragmatic weakness, due to both atrophy and contractile dysfunction, is a significant contributor to weaning difficulties...
  64. Mechanical ventilation, oxidative stress, and diaphragmatic atrophy
    Scott Powers; Fiscal Year: 2009
    ..Studies indicate that MV-induced diaphragmatic weakness, due to both atrophy and contractile dysfunction, is a significant contributor to weaning difficulties...
  65. Acute Lung Injury Induces Skeletal Muscle Atrophy
    DANIEL FILES; Fiscal Year: 2009
    ..Our preliminary data show that ALI mice develop skeletal muscle atrophy, measured by histological changes and by activation of skeletal muscle specific protein degradation pathways...
  66. Motoneuron-selective Rescue of SMA Model Mice
    Mendell Rimer; Fiscal Year: 2012
    ..provided by applicant): Lower motoneuron death is believed to be the primary defect in spinal muscular atrophy (SMA), a childhood hereditary neuromuscular disease almost as prevalent as cystic fibrosis, perhaps the best-..
  67. Mechanisms of Gastric Mucous Cell Metaplasia
    JAMES RICHARD GOLDENRING; Fiscal Year: 2010
    ..The loss of parietal cells (oxyntic atrophy) is a critical step in the pathogenesis of chronic gastritis and gastric cancer...
  68. Attenuation of denervation atrophy by nandrolone: molecular mechanisms
    Christopher Cardozo; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Androgenic steroids reduce muscle atrophy through molecular mechanisms that are poorly understood...
  69. Mechanisms of Gastric Mucous Cell Metaplasia
    James Goldenring; Fiscal Year: 2009
    ..The loss of parietal cells (oxyntic atrophy) is a critical step in the pathogenesis of chronic gastritis and gastric cancer...
  70. Spinal Muscular Atrophy: inducing SMN expression
    CHRISTINE DIDONATO; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Spinal Muscular Atrophy (SMA), a common autosomal recessive motor neuron disorder that is the leading genetic cause of infant mortality...
  71. Spinal Muscular Atrophy: inducing SMN expression
    CHRISTINE DIDONATO; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Spinal Muscular Atrophy (SMA), a common autosomal recessive motor neuron disorder that is the leading genetic cause of infant mortality...
  72. Spinal Muscular Atrophy: inducing SMN expression
    CHRISTINE DIDONATO; Fiscal Year: 2007
    Spinal Muscular Atrophy (SMA), a common autosomal recessive motor neuron disorder that is the leading genetic cause of infant mortality. SMA is caused by the loss of the survival motor neuron gene (SMN1)...
  73. Spinal Muscular Atrophy: inducing SMN expression
    CHRISTINE DIDONATO; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Spinal Muscular Atrophy (SMA), a common autosomal recessive motor neuron disorder that is the leading genetic cause of infant mortality...
  74. Targeting SMN2 Alternative Splicing for the Treatment of Spinal Muscular Atrophy
    Michelle L Hastings; Fiscal Year: 2010
    ..One disease that can potentially be cured by targeting pre- mRNA splicing is spinal muscular atrophy (SMA). SMA is a pediatric neurodegenerative disease for which there is currently no cure or effective therapy...
  75. Spinal Muscular Atrophy: inducing SMN expression
    CHRISTINE DIDONATO; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Spinal Muscular Atrophy (SMA), a common autosomal recessive motor neuron disorder that is the leading genetic cause of infant mortality...
  76. Muscle and neuromuscular junctions in spinal muscular atrophy
    CHARLOTTE SUMNER; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Spinal muscular atrophy (SMA) is a currently untreatable, autosomal recessive motor neuron disease that is the leading inherited cause of infant mortality...
  77. PROPOSED RAT MODEL OF OLIVOPONTOCEREBELLAR ATROPHY
    CHERYL GUYER; Fiscal Year: 1999
    Olivopontocerebellar atrophy (OPCA) is one entity in a diverse group of familial, progressive, neurodegenerative disorders in man and animals that is characterized by variable atrophy of the cerebellum, basis pontis, and olivary nuclei...
  78. PROPOSED RAT MODEL OF OLIVOPONTOCEREBELLAR ATROPHY
    CHERYL GUYER; Fiscal Year: 2000
    Olivopontocerebellar atrophy (OPCA) is one entity in a diverse group of familial, progressive, neurodegenerative disorders in man and animals that is characterized by variable atrophy of the cerebellum, basis pontis, and olivary nuclei...
  79. Mouse Models of Gastric Cancer
    Timothy Wang; Fiscal Year: 2001
    ..Previous investigations have suggested that parietal cell loss or gastric atrophy represents a key preneoplastic precursor...
  80. Mouse Models of Gastric Cancer
    Timothy Wang; Fiscal Year: 2005
    ..Previous investigations have suggested that parietal cell loss or gastric atrophy represents a key preneoplastic precursor...
  81. Mouse Models of Gastric Cancer
    Timothy Wang; Fiscal Year: 2004
    ..Previous investigations have suggested that parietal cell loss or gastric atrophy represents a key preneoplastic precursor...
  82. Mouse Models of Gastric Cancer
    Timothy Wang; Fiscal Year: 2003
    ..Previous investigations have suggested that parietal cell loss or gastric atrophy represents a key preneoplastic precursor...
  83. Mouse Models of Gastric Cancer
    Timothy Wang; Fiscal Year: 2002
    ..Previous investigations have suggested that parietal cell loss or gastric atrophy represents a key preneoplastic precursor...
  84. Testing Compounds that Increase SMN levels for Efficacy in Mouse Models of SMA
    Elliot Androphy; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Spinal muscular atrophy (SMA) is an autosomal recessive form of muscular dystrophy that afflicts approximately 1 in 6,000 live births and clinically manifests as progressive muscle weakness due to ..
  85. Mouse Models of Gastric Cancer
    Timothy Wang; Fiscal Year: 2004
    ..Previous investigations have suggested that parietal cell loss or gastric atrophy represents a key preneoplastic precursor...
  86. Therapeutic Strategies to Augment Muscle Rehabilitation
    Krista Vandenborne; Fiscal Year: 2009
    The long-range of this project is to develop novel therapeutic strategies that ameliorate muscle atrophy and accelerate muscle rehabilitation following pathological conditions such as spinal cord injury...
  87. Large Animal Model of Spinal Muscular Atrophy
    MONIQUE LORSON; Fiscal Year: 2009
    ..Project summary/abstract: This application proposes the generation of a swine model of Spinal Muscular Atrophy (SMA) (pSMN1-/-;hSMN2) using somatic cell nuclear transfer of gene targeted fetal fibroblasts and breeding...
  88. Spinal Muscular Atrophy: Is it a motor axon disease?
    CHRISTINE BEATTIE; Fiscal Year: 2009
    Spinal muscular atrophy (SMA) is an autosomal recessive disease and one of the leading causes of infant mortality. To elucidate the biological mechanism underlying this motoneuron disease, SMA has been modeled in mice and zebrafish...
  89. Spinal Muscular Atrophy: Is it a motor axon disease?
    CHRISTINE BEATTIE; Fiscal Year: 2009
    Spinal muscular atrophy (SMA) is an autosomal recessive disease and one of the leading causes of infant mortality. To elucidate the biological mechanism underlying this motoneuron disease, SMA has been modeled in mice and zebrafish...
  90. Optimizing automated MRI measures of atrophy in neurodegenerative disease
    Ronald Pierson; Fiscal Year: 2012
    ..with both the standard FreeSurfer and the longitudinal stream in FreeSurfer, our methods detect a higher annual atrophy rate with a lower relative standard deviation...
  91. NON-INVASIVE MEASUREMENT OF RPE LIPOFUSCIN
    Francois DeLori; Fiscal Year: 2001
    ..Its hallmarks are neovascularization and/or atrophy of photoreceptors and retinal pigment epithelial cells (RPE)...
  92. CLINICAL TRIALS FOR PEDIATRIC SPINAL MUSCULAR ATROPHY
    Susan Iannaccone; Fiscal Year: 2000
    Spinal muscular atrophy (SMA) is an autosomal recessive genetic disease of the anterior horn cell of the spinal cord; this disease is attributable to mutations in the 5q11 site which includes the SMN (survival motor neuron), the neuronal ..
  93. CLINICAL TRIALS FOR PEDIATRIC SPINAL MUSCULAR ATROPHY
    Susan Iannaccone; Fiscal Year: 2001
    Spinal muscular atrophy (SMA) is an autosomal recessive genetic disease of the anterior horn cell of the spinal cord; this disease is attributable to mutations in the 5q11 site which includes the SMN (survival motor neuron), the neuronal ..
  94. NON-INVASIVE MEASUREMENT OF RPE LIPOFUSCIN
    Francois DeLori; Fiscal Year: 2002
    ..Its hallmarks are neovascularization and/or atrophy of photoreceptors and retinal pigment epithelial cells (RPE)...
  95. CLINICAL TRIALS FOR PEDIATRIC SPINAL MUSCULAR ATROPHY
    Susan Iannaccone; Fiscal Year: 2002
    Spinal muscular atrophy (SMA) is an autosomal recessive genetic disease of the anterior horn cell of the spinal cord; this disease is attributable to mutations in the 5q11 site which includes the SMN (survival motor neuron), the neuronal ..
  96. Peripapillary Atrophy Progression During The Ocular Hypertension Treatment Study
    Donald L Budenz; Fiscal Year: 2010
    ..The overall goal of this study is to assess the prognostic significance of per papillary atrophy (PPA) progression during the course of ocular hypertension (OHT)...
  97. Novel Gene Delivery Development for Spinal Muscular Atrophy
    Brian Kaspar; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Spinal muscular atrophy (SMA) is a genetic disorder characterized by the loss of lower motor neurons (LMNs) residing along the entire length of the spinal cord...
  98. NON-INVASIVE MEASUREMENT OF RPE LIPOFUSCIN
    Francois DeLori; Fiscal Year: 2005
    ..Its hallmarks are neovascularization and/or atrophy of photoreceptors and retinal pigment epithelial cells (RPE)...