atrophy

Summary

Summary: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.

Top Publications

  1. ncbi Accurate, robust, and automated longitudinal and cross-sectional brain change analysis
    Stephen M Smith
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, FMRIB, University of Oxford, John Radcliffe Hospital, Headley Way, Headington, Oxford, United Kingdom
    Neuroimage 17:479-89. 2002
  2. ncbi A voxel-based morphometric study of ageing in 465 normal adult human brains
    C D Good
    Wellcome Department of Cognitive Neurology, Institute of Neurology, London, United Kingdom
    Neuroimage 14:21-36. 2001
  3. ncbi Regional brain atrophy and functional disconnection across Alzheimer's disease evolution
    T Gili
    MARBILab, Enrico Fermi Centre, Rome, Italy
    J Neurol Neurosurg Psychiatry 82:58-66. 2011
  4. pmc Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2
    Xiao ding Peng
    Department of Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Genes Dev 17:1352-65. 2003
  5. ncbi Gray matter atrophy in multiple sclerosis: a longitudinal study
    Elizabeth Fisher
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Ann Neurol 64:255-65. 2008
  6. pmc Disability, atrophy and cortical reorganization following spinal cord injury
    Patrick Freund
    Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK
    Brain 134:1610-22. 2011
  7. pmc Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer's disease
    Clifford R Jack
    Department of Radiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Brain 133:3336-48. 2010
  8. ncbi Issues with threshold masking in voxel-based morphometry of atrophied brains
    Gerard R Ridgway
    Centre for Medical Image Computing CMIC, Department of Medical Physics and Bioengineering, University College London, WC1E 6BT, London, UK
    Neuroimage 44:99-111. 2009
  9. pmc Denervation causes fiber atrophy and myosin heavy chain co-expression in senescent skeletal muscle
    Sharon L Rowan
    Muscle and Aging Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Canada
    PLoS ONE 7:e29082. 2012
  10. ncbi Basal ganglia, thalamus and neocortical atrophy predicting slowed cognitive processing in multiple sclerosis
    Sônia Batista
    Department of Neurology, Coimbra University Hospitals, Coimbra, Portugal
    J Neurol 259:139-46. 2012

Detail Information

Publications288 found, 100 shown here

  1. ncbi Accurate, robust, and automated longitudinal and cross-sectional brain change analysis
    Stephen M Smith
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, FMRIB, University of Oxford, John Radcliffe Hospital, Headley Way, Headington, Oxford, United Kingdom
    Neuroimage 17:479-89. 2002
    Quantitative measurement of brain size, shape, and temporal change (for example, in order to estimate atrophy) is increasingly important in biomedical image analysis applications...
  2. ncbi A voxel-based morphometric study of ageing in 465 normal adult human brains
    C D Good
    Wellcome Department of Cognitive Neurology, Institute of Neurology, London, United Kingdom
    Neuroimage 14:21-36. 2001
    ..There was no interaction of age with sex for regionally specific effects. These results corroborate previous reports and indicate that VBM is a useful technique for studying structural brain correlates of ageing through life in humans...
  3. ncbi Regional brain atrophy and functional disconnection across Alzheimer's disease evolution
    T Gili
    MARBILab, Enrico Fermi Centre, Rome, Italy
    J Neurol Neurosurg Psychiatry 82:58-66. 2011
    To assess the contribution of regional grey matter (GM) atrophy and functional disconnection in determining the level of cognitive decline in patients with Alzheimer's disease (AD) at different clinical stages.
  4. pmc Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2
    Xiao ding Peng
    Department of Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Genes Dev 17:1352-65. 2003
    ..These mice display impaired skin development because of a proliferation defect, severe skeletal muscle atrophy because of a marked decrease in individual muscle cell size, and impaired bone development...
  5. ncbi Gray matter atrophy in multiple sclerosis: a longitudinal study
    Elizabeth Fisher
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Ann Neurol 64:255-65. 2008
    To determine gray matter (GM) atrophy rates in multiple sclerosis (MS) patients at all stages of disease, and to identify predictors and clinical correlates of GM atrophy.
  6. pmc Disability, atrophy and cortical reorganization following spinal cord injury
    Patrick Freund
    Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK
    Brain 134:1610-22. 2011
    ..In conclusion, spinal cord injury leads to cord atrophy, cortical atrophy of primary motor and sensory cortex, and cortical reorganization of the sensorimotor system...
  7. pmc Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer's disease
    Clifford R Jack
    Department of Radiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Brain 133:3336-48. 2010
    ..Our objective was to evaluate the ability of Aβ load and neurodegenerative atrophy on magnetic resonance imaging to predict shorter time-to-progression from mild cognitive impairment to Alzheimer'..
  8. ncbi Issues with threshold masking in voxel-based morphometry of atrophied brains
    Gerard R Ridgway
    Centre for Medical Image Computing CMIC, Department of Medical Physics and Bioengineering, University College London, WC1E 6BT, London, UK
    Neuroimage 44:99-111. 2009
    ..risk of excluding from the analysis precisely those voxels where the subjects' brains were most vulnerable to atrophy. We investigate the issues related to mask construction, and recommend the use of alternative strategies which ..
  9. pmc Denervation causes fiber atrophy and myosin heavy chain co-expression in senescent skeletal muscle
    Sharon L Rowan
    Muscle and Aging Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Canada
    PLoS ONE 7:e29082. 2012
    Although denervation has long been implicated in aging muscle, the degree to which it is causes the fiber atrophy seen in aging muscle is unknown...
  10. ncbi Basal ganglia, thalamus and neocortical atrophy predicting slowed cognitive processing in multiple sclerosis
    Sônia Batista
    Department of Neurology, Coimbra University Hospitals, Coimbra, Portugal
    J Neurol 259:139-46. 2012
    ..To determine if basal ganglia and thalamus atrophy independently contribute to visual and auditory IPS impairment in MS, after controlling for the influence of ..
  11. pmc Regional brain stem atrophy in idiopathic Parkinson's disease detected by anatomical MRI
    Thomas Jubault
    Unité de Neuroimagerie Fonctionelle, Institut Universitaire de Geriatrie de Montreal, Montreal, Quebec, Canada
    PLoS ONE 4:e8247. 2009
    ..This damage could also explain some non-motor symptoms in PD that often precede diagnosis, such as autonomic dysfunction and sleep disorders...
  12. ncbi Return to the fetal gene program protects the stressed heart: a strong hypothesis
    Mitra Rajabi
    Department of Internal Medicine, Division of Cardiology, University of Texas Houston Medical School, 6431 Fannin, Houston, TX 77030, USA
    Heart Fail Rev 12:331-43. 2007
    ..program is predominant in a variety of pathophysiologic conditions including hypoxia, ischemia, hypertrophy, and atrophy. A common feature of all of these conditions is extensive remodeling, a decrease in the rate of aerobic ..
  13. ncbi A voxel-based morphometry study of patterns of brain atrophy in ALS and ALS/FTLD
    J L Chang
    Department of Neurology, University of California San Francisco, CA, USA
    Neurology 65:75-80. 2005
    To investigate the patterns of MRI brain atrophy in patients with ALS with and without clinically evident frontotemporal lobar dementia (FTLD) using voxel-based morphometry (VBM).
  14. ncbi Imaging cerebral atrophy: normal ageing to Alzheimer's disease
    Nick C Fox
    Dementia Research Group, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Lancet 363:392-4. 2004
    ..Alzheimer's disease is associated with progressive cerebral atrophy, which can be seen on MRI with high resolution...
  15. pmc The val158met COMT polymorphism's effect on atrophy in healthy aging and Parkinson's disease
    J B Rowe
    University of Cambridge, Department of Clinical Neurosciences, Cambridge, UK
    Neurobiol Aging 31:1064-8. 2010
    ..val(158)met polymorphism is associated with differences in cortical dopamine metabolism, our data suggest a role for dopamine in cortical development followed by differential vulnerability to cortical atrophy across the adult life span.
  16. pmc Bias in estimation of hippocampal atrophy using deformation-based morphometry arises from asymmetric global normalization: an illustration in ADNI 3 T MRI data
    Paul A Yushkevich
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroimage 50:434-45. 2010
    ..is manifested as a non-zero intercept of the regression line fitted to the 6 and 12 month rates of hippocampal atrophy. The bias is further confirmed by applying DBM to repeat scans of subjects acquired on the same day...
  17. pmc Reduced lean mass in early Alzheimer disease and its association with brain atrophy
    Jeffrey M Burns
    Department of Neurology, University of Kansas School of Medicine, 3599 Rainbow Blvd, Kansas City, KS 66160, USA
    Arch Neurol 67:428-33. 2010
    ..To examine body composition in individuals with early AD and without dementia and its relation to cognition and brain volume...
  18. ncbi The progression of regional atrophy in premanifest and early Huntington's disease: a longitudinal voxel-based morphometry study
    Nicola Z Hobbs
    Dementia Research Centre, UCL Institute of Neurology, University College London, London, UK
    J Neurol Neurosurg Psychiatry 81:756-63. 2010
    ..They may also provide tools for assessing disease-modifying interventions. The authors investigated the progression of regional atrophy in premanifest and early HD compared with controls.
  19. pmc Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases
    Viviana Moresi
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell 143:35-45. 2010
    ..skeletal muscle structure and function requires innervation by motor neurons, such that denervation causes muscle atrophy. We show that myogenin, an essential regulator of muscle development, controls neurogenic atrophy...
  20. pmc Longitudinal MRI atrophy biomarkers: relationship to conversion in the ADNI cohort
    Shannon L Risacher
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University, School of Medicine, 950 W Walnut St, Indianapolis, IN 46202, United States
    Neurobiol Aging 31:1401-18. 2010
    ..We analyzed magnetic resonance imaging (MRI) atrophy rate from baseline to 1 year in 4 groups of participants from the Alzheimer's Disease Neuroimaging Initiative (..
  21. pmc Cardiorespiratory fitness and brain atrophy in early Alzheimer disease
    J M Burns
    Department of Neurology, Hoglund Brain Imaging Center, University of Kansas School of Medicine, 3599 Rainbow Blvd, MSN 2012, Kansas City, KS 66160, USA
    Neurology 71:210-6. 2008
    To examine the correlation of cardiorespiratory fitness with brain atrophy and cognition in early-stage Alzheimer disease (AD).
  22. pmc Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease
    C R Jack
    Department of Diagnostic Radiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Neurology 49:786-94. 1997
    ..99 SD, and moderate AD (CDR 2) -2.22 SD. Age- and gender-adjusted, normalized MRI-based hippocampal volumetric measurements provide a sensitive marker of the MTL neuroanatomic degeneration in AD early in the disease process...
  23. pmc The impact of lesion in-painting and registration methods on voxel-based morphometry in detecting regional cerebral gray matter atrophy in multiple sclerosis
    A Ceccarelli
    Department of Neurology, Brigham and Women s Hospital, Laboratory for Neuroimaging Research, Partners MS Center, Harvard Medical School, Boston, MA 02445, USA
    AJNR Am J Neuroradiol 33:1579-85. 2012
    VBM has been widely used to study GM atrophy in MS. MS lesions lead to segmentation and registration errors that may affect the reliability of VBM results...
  24. ncbi Subcortical and cortical gray matter atrophy in a large sample of patients with clinically isolated syndrome and early relapsing-remitting multiple sclerosis
    N Bergsland
    Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, NY 14203, USA
    AJNR Am J Neuroradiol 33:1573-8. 2012
    Recent studies have shown that selective regional, but not global, GM atrophy occurs from clinical onset to conversion to clinically definite MS...
  25. ncbi Atypical form of Alzheimer's disease with prominent posterior cortical atrophy: a review of lesion distribution and circuit disconnection in cortical visual pathways
    P R Hof
    Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Vision Res 37:3609-25. 1997
    ....
  26. ncbi AddNeuroMed and ADNI: similar patterns of Alzheimer's atrophy and automated MRI classification accuracy in Europe and North America
    Eric Westman
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    Neuroimage 58:818-28. 2011
    ..We hypothesized that the two cohorts would show similar patterns of atrophy, despite demographic differences and could therefore be combined...
  27. ncbi Clinical, genetic, and neuropathologic characteristics of posterior cortical atrophy
    D F Tang-Wai
    Department of Neurology, Mayo Alzheimer s Disease Research Center, Rochester, MN, USA
    Neurology 63:1168-74. 2004
    To examine the clinical, genetic, and neuropathologic features of posterior cortical atrophy (PCA).
  28. ncbi Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: involvement of glucocorticoid secretion and excitatory amino acid receptors
    A M Magarinos
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    Neuroscience 69:89-98. 1995
    Repeated restraint stress of rats for 21 days causes atrophy of apical dendrites of hippocampal CA3c pyramidal neurons...
  29. ncbi Persistent cognitive impairment, hippocampal atrophy and EEG changes in sepsis survivors
    Alexander Semmler
    Department of Neurology, University of Bonn, Bonn, Germany
    J Neurol Neurosurg Psychiatry 84:62-9. 2013
    ....
  30. pmc Cerebral atrophy in mild cognitive impairment and Alzheimer disease: rates and acceleration
    Kelvin K Leung
    Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK
    Neurology 80:648-54. 2013
    To quantify the regional and global cerebral atrophy rates and assess acceleration rates in healthy controls, subjects with mild cognitive impairment (MCI), and subjects with mild Alzheimer disease (AD).
  31. ncbi Whole-brain and regional brain atrophy in amyotrophic lateral sclerosis
    D M Mezzapesa
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    AJNR Am J Neuroradiol 28:255-9. 2007
    ..Our purpose was to obtain measures of global and regional atrophy in nondemented patients with ALS to assess subtle structural brain changes.
  32. pmc Impaired sprouting and axonal atrophy in cerebellar climbing fibres following in vivo silencing of the growth-associated protein GAP-43
    Giorgio Grasselli
    Santa Lucia Foundation IRCCS, Rome, Italy
    PLoS ONE 6:e20791. 2011
    ..We show that lack of GAP-43 causes an atrophy of the CF in non-traumatic conditions, consisting in a decrease of its length, branching and number of synaptic ..
  33. pmc Spatial patterns of brain atrophy in MCI patients, identified via high-dimensional pattern classification, predict subsequent cognitive decline
    Yong Fan
    Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Neuroimage 39:1731-43. 2008
    Spatial patterns of brain atrophy in mild cognitive impairment (MCI) and Alzheimer's disease (AD) were measured via methods of computational neuroanatomy. These patterns were spatially complex and involved many brain regions...
  34. pmc Segmentation of brain magnetic resonance images for measurement of gray matter atrophy in multiple sclerosis patients
    Kunio Nakamura
    Department of Biomedical Engineering ND20, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Neuroimage 44:769-76. 2009
    ..exist for segmentation of GM, but none were specifically designed to handle issues associated with MS, such as atrophy and the effects that MS lesions may have on the classification of GM...
  35. ncbi PI3 kinase regulation of skeletal muscle hypertrophy and atrophy
    David J Glass
    Novartis Institute for Biomedical Research, Cambridge, MA 02139, USA
    Curr Top Microbiol Immunol 346:267-78. 2010
    ..that can induce protein synthesis and block the transcriptional upregulation of key mediators of skeletal muscle atrophy, the E3 ubiquitin ligases MuRF1 and MAFbx (also called Atrogin-1), by phosphorylating and thereby inhibiting the ..
  36. ncbi Thalamic atrophy associated with painful osteoarthritis of the hip is reversible after arthroplasty: a longitudinal voxel-based morphometric study
    Stephen E Gwilym
    University of Oxford, Oxford, UK
    Arthritis Rheum 62:2930-40. 2010
    ..From this previous work, it appears that chronic pain is associated with altered brain morphology. The present study was undertaken to assess these potential alterations in patients with painful hip osteoarthritis (OA)...
  37. pmc Inflammation, atrophy, and gastric cancer
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Invest 117:60-9. 2007
    ..population and is now known to be responsible for inducing chronic gastric inflammation that progresses to atrophy, metaplasia, dysplasia, and gastric cancer...
  38. ncbi A longitudinal study of brain volume changes in normal aging using serial registered magnetic resonance imaging
    Rachael I Scahill
    Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, University College London, England
    Arch Neurol 60:989-94. 2003
    To investigate the effect of age on global and regional brain volumes and rates of atrophy, and to compare directly results based on cross-sectional and longitudinal data.
  39. ncbi Increased brain atrophy rates in cognitively normal older adults with low cerebrospinal fluid Aβ1-42
    Jonathan M Schott
    Dementia Research Centre, University College London, Institute of Neurology, London, United Kingdom
    Ann Neurol 68:825-34. 2010
    To identify cognitively normal individuals at risk of Alzheimer disease (AD) based on cerebrospinal fluid (CSF) Aβ1-42, and to determine rates of cerebral atrophy.
  40. pmc Robust atrophy rate measurement in Alzheimer's disease using multi-site serial MRI: tissue-specific intensity normalization and parameter selection
    Kelvin K Leung
    Dementia Research Centre DRC, Institute of Neurology, University College London, London, UK
    Neuroimage 50:516-23. 2010
    We describe an improved method of measuring brain atrophy rates from serial MRI for multi-site imaging studies of Alzheimer's disease (AD)...
  41. pmc Mapping the evolution of regional atrophy in Alzheimer's disease: unbiased analysis of fluid-registered serial MRI
    Rachael I Scahill
    Dementia Research Group, Department of Clinical Neurology, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom
    Proc Natl Acad Sci U S A 99:4703-7. 2002
    Alzheimer's disease (AD) is characterized by progressive cerebral atrophy, which may be assessed by using volumetric MRI...
  42. pmc Association of retinal and macular damage with brain atrophy in multiple sclerosis
    Jan Dorr
    NeuroCure Clinical Research Center, Charite Universitaetsmedizin Berlin, Berlin, Germany
    PLoS ONE 6:e18132. 2011
    ..However, crucial aspects including the association between OCT- and MRI-based atrophy measures or the impact of MS-related parameters on OCT parameters are still unclear...
  43. ncbi MRI volumetry of the thalamus in temporal, extratemporal, and idiopathic generalized epilepsy
    Jun Natsume
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute and Hospital, Quebec, Canada
    Neurology 60:1296-300. 2003
    To examine the specificity of thalamic atrophy in epilepsy.
  44. ncbi Thalamic atrophy and cognition in multiple sclerosis
    M K Houtchens
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Partners MS Center, Boston, MA 02115, USA
    Neurology 69:1213-23. 2007
    Recent studies have indicated that brain atrophy is more closely associated with cognitive impairment in multiple sclerosis (MS) than are conventional MRI lesion measures...
  45. pmc Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer's disease
    Susanne G Mueller
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Hum Brain Mapp 31:1339-47. 2010
    ..2) To determine if measurements of hippocampal subfields provide advantages over total hippocampal volume for differentiation between groups...
  46. ncbi Gray matter atrophy is related to long-term disability in multiple sclerosis
    Leonora K Fisniku
    Nuclear Magnetic Resonance Research Unit, Institute of Neurology, University College London, UK
    Ann Neurol 64:247-54. 2008
    ..To determine the relation of gray matter (GM) and white matter (WM) brain volumes, and WM lesion load, with clinical outcomes 20 years after first presentation with clinically isolated syndrome suggestive of multiple sclerosis (MS)...
  47. ncbi White matter damage in Alzheimer disease and its relationship to gray matter atrophy
    Federica Agosta
    Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Radiology 258:853-63. 2011
    ..damage in (a) patients with probable Alzheimer disease (AD) and (b) patients with amnestic mild cognitive impairment (aMCI) and at least one abnormal biomarker and to investigate whether WM damage is related to gray matter (GM) atrophy.
  48. ncbi Automatic differentiation of anatomical patterns in the human brain: validation with studies of degenerative dementias
    Catriona D Good
    Wellcome Department of Cognitive Neurology, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, United Kingdom
    Neuroimage 17:29-46. 2002
    ..In conclusion, the automated technique detects a general trend of atrophy similar to that of expertly labeled ROI measurements in AD and SD, although there are discrepancies in the ..
  49. pmc Validation study of villous atrophy and small intestinal inflammation in Swedish biopsy registers
    Jonas F Ludvigsson
    Department of Pediatrics, Orebro University Hospital, Orebro, Sweden
    BMC Gastroenterol 9:19. 2009
    Small intestinal biopsy with villous atrophy (VA) is the gold standard for the diagnosis of celiac disease (CD). We validated VA (Marsh 3) and small intestinal inflammation without VA (Marsh 1+2) in Swedish regional biopsy registers.
  50. pmc NF-κB inhibition protects against tumor-induced cardiac atrophy in vivo
    Ashley Wysong
    Duke University School of Medicine, Durham, North Carolina, USA
    Am J Pathol 178:1059-68. 2011
    ..cachexia (C26 adenocarcinoma), we determined how these drugs affected the development of tumor-induced cardiac atrophy and function...
  51. ncbi Essential head tremor is associated with cerebellar vermis atrophy: a volumetric and voxel-based morphometry MR imaging study
    A Quattrone
    Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy
    AJNR Am J Neuroradiol 29:1692-7. 2008
    ..Our aim was to investigate the presence of brain gray matter (GM) abnormalities in patients with different forms of essential tremor (ET)...
  52. ncbi Topical estrogen therapy in the management of postmenopausal vaginal atrophy: an up-to-date overview
    O Al-Baghdadi
    Obstetrics and Gynaecology, Frimley Park Hospital, London
    Climacteric 12:91-105. 2009
    Vaginal atrophy, a manifestation of estrogen deprivation after the menopause, could affect up to 60% of women, with a significant impact on their quality of life. It is often under-diagnosed and inadequately treated...
  53. ncbi Cortical lesions and atrophy associated with cognitive impairment in relapsing-remitting multiple sclerosis
    Massimiliano Calabrese
    Multiple Sclerosis Centre of Veneto Region, First Neurology Clinic, Department of Neurosciences, University Hospital of Padua
    Arch Neurol 66:1144-50. 2009
    ..Double inversion recovery sequences allow cortical lesions (CLs) to be detected in the brain of patients with MS. Modern postprocessing techniques allow cortical atrophy to be assessed reliably.
  54. ncbi Assessment of lateral geniculate nucleus atrophy with 3T MR imaging and correlation with clinical stage of glaucoma
    H Dai
    Department of Radiology, Tongji Hospital, Huazhong University of Science and Technology University, Wuhan, China
    AJNR Am J Neuroradiol 32:1347-53. 2011
    Although previous animal studies have shown structural changes in ocular hypertension such as atrophy of the LGN, such changes have not been thoroughly studied in human glaucoma patients nor correlation made with clinical stage...
  55. pmc Microstructural white matter changes, not hippocampal atrophy, detect early amnestic mild cognitive impairment
    Lin Zhuang
    Centre for Healthy Brain Ageing, University of New South Wales, Randwick, New South Wales, Australia
    PLoS ONE 8:e58887. 2013
    ..The evolution of white matter deterioration and its relationship with gray matter atrophy remains elusive in amnestic mild cognitive impairment (aMCI), a prodromal stage of AD.
  56. pmc Plasma biomarkers of brain atrophy in Alzheimer's disease
    Madhav Thambisetty
    Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 6:e28527. 2011
    ..The most widely used indicator of AD pathology in life at present is neuroimaging evidence of brain atrophy. We therefore performed a proteomic analysis of plasma to derive biomarkers associated with brain atrophy in AD...
  57. pmc Serological assessment of gastric mucosal atrophy in gastric cancer
    Jan Bornschein
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University of Magdeburg, Magdeburg, Germany
    BMC Gastroenterol 12:10. 2012
    ..Aim of this study was to assess the performance of these serological tests in the presence of gastric neoplasia...
  58. pmc Hippocampal atrophy and ventricular enlargement in normal aging, mild cognitive impairment (MCI), and Alzheimer Disease
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Alzheimer Dis Assoc Disord 26:17-27. 2012
    Alzheimer disease (AD) is the most common type of dementia worldwide. Hippocampal atrophy and ventricular enlargement have been associated with AD but also with normal aging. We analyzed 1...
  59. pmc CLADA: cortical longitudinal atrophy detection algorithm
    Kunio Nakamura
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Neuroimage 54:278-89. 2011
    Measurement of changes in brain cortical thickness is useful for the assessment of regional gray matter atrophy in neurodegenerative conditions...
  60. pmc Longitudinal progression of Alzheimer's-like patterns of atrophy in normal older adults: the SPARE-AD index
    Christos Davatzikos
    Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Brain 132:2026-35. 2009
    ..Recent literature suggests that spatial patterns of brain atrophy discriminate amongst Alzheimer's disease, mild cognitive impairment (MCI) and cognitively normal (CN) older ..
  61. pmc Gray matter atrophy rate as a marker of disease progression in AD
    Valerie M Anderson
    Department of Neuroinflammation, UCL Institute of Neurology, Queen Square, London, UK
    Neurobiol Aging 33:1194-202. 2012
    Global gray matter (GM) atrophy rates were quantified from magnetic resonance imaging (MRI) over 6- and 12-month intervals in 37 patients with Alzheimer's disease (AD) and 19 controls using: (1) nonlinear registration and integration of ..
  62. pmc Cancer causes cardiac atrophy and autophagy in a sexually dimorphic manner
    Pippa F Cosper
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado, USA
    Cancer Res 71:1710-20. 2011
    ..The heart also undergoes atrophy in cancer patients, but the mechanisms and the basis for apparent sex differences are unclear...
  63. ncbi Brain atrophy accelerates cognitive decline in cerebral small vessel disease: the LADIS study
    H Jokinen
    Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland
    Neurology 78:1785-92. 2012
    To examine the independent contributions and combined interactions of medial temporal lobe atrophy (MTA), cortical and subcortical atrophy, and white matter lesion (WML) volume in longitudinal cognitive performance.
  64. ncbi Mesial temporal damage in temporal lobe epilepsy: a volumetric MRI study of the hippocampus, amygdala and parahippocampal region
    N Bernasconi
    Department of Neurology and Neurosurgery, McGill University and Montreal Neurological Institute and Hospital, Montreal, Quebec, Canada
    Brain 126:462-9. 2003
    ..and posterior parahippocampal cortex were detectable by MRI; and (ii) to study the distribution and degree of atrophy in mesial temporal structures including the hippocampal head, body and tail, amygdala, entorhinal cortex, ..
  65. pmc Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial
    A David Smith
    Oxford Project to Investigate Memory and Ageing, University of Oxford, Oxford, United Kingdom
    PLoS ONE 5:e12244. 2010
    An increased rate of brain atrophy is often observed in older subjects, in particular those who suffer from cognitive decline. Homocysteine is a risk factor for brain atrophy, cognitive impairment and dementia...
  66. pmc Age-associated reductions in cerebral blood flow are independent from regional atrophy
    J Jean Chen
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 55:468-78. 2011
    ..the spatial distribution of such changes, potentially a result of neglecting the effect of age-related tissue atrophy in CBF measurements...
  67. pmc Effects of ApoE4 and maternal history of dementia on hippocampal atrophy
    John P Andrawis
    Pritzker School of Medicine, University of Chicago, Chicago, IL, USA
    Neurobiol Aging 33:856-66. 2012
    ..maternal history of dementia had smaller hippocampal volumes at baseline and at follow-up, and greater 12-month atrophy rates than subjects with negative maternal history...
  68. ncbi Foveal crowding in posterior cortical atrophy: a specific early-visual-processing deficit affecting word reading
    Sebastian J Crutch
    Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College London, London, UK
    Cogn Neuropsychol 24:843-66. 2007
    ..with peripheral dyslexia and a third with visual disorientation consequent to bilateral posterior cortical atrophy. In one case, reading showed the effects of word length typical of letter-by-letter reading, whereas the second ..
  69. pmc Age-related cerebral atrophy in nonhuman primates predicts cognitive impairments
    Jean Luc Picq
    Laboratoire de psychopathologie et de neuropsychologie, EA, 2027, Université Paris 8, 2 rue de la liberté, 93000 St Denis, France
    Neurobiol Aging 33:1096-109. 2012
    ..not in nonhuman primates, a clear relationship has been established between age-associated cognitive decline and atrophy of specific brain regions...
  70. pmc Hypertrophic cardiomyopathy in high-fat diet-induced obesity: role of suppression of forkhead transcription factor and atrophy gene transcription
    Cindy X Fang
    Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA
    Am J Physiol Heart Circ Physiol 295:H1206-H1215. 2008
    ..Foxo transcription factors initiate an atrophy-related gene program to counter hypertrophic growth...
  71. ncbi Age-related choroidal atrophy
    Richard F Spaide
    Vitreous Retina Macula Consultants of New York and the LuEsther T Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York 10022, USA
    Am J Ophthalmol 147:801-10. 2009
    To report the clinical characteristics of a newly defined entity, age-related choroidal atrophy.
  72. ncbi Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy
    George J Francis
    Department of Clinical Neurosciences and the Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    Brain 131:3311-34. 2008
    Insulin deficiency in type I diabetes may lead to cognitive impairment, cerebral atrophy and white matter abnormalities...
  73. pmc One-year brain atrophy evident in healthy aging
    Anders M Fjell
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, 0317 Oslo, Norway
    J Neurosci 29:15223-31. 2009
    ..Some of the atrophy occurred in areas vulnerable to AD, while other changes were observed in areas less characteristic of the disease ..
  74. ncbi The pattern of cortical atrophy in patients with Parkinson's disease according to cognitive status
    Sook K Song
    Department of Neurology, Jeju University College of Medicine, Jeju, Korea
    Mov Disord 26:289-96. 2011
    ..Cognitive dysfunction is common in Parkinson's disease (PD), and along with PD with dementia (PDD), the concept of mild cognitive impairment in PD (PD-MCI) has been introduced...
  75. ncbi Focal cortical presentations of Alzheimer's disease
    S Alladi
    Department of Clinical Neurosciences, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Brain 130:2636-45. 2007
    ..AD) pathology in patients presenting with progressive focal cortical syndromes, notably posterior cortical atrophy (PCA), corticobasal syndrome (CBS), behavioural variant frontotemporal dementia (bvFTD), progressive non-fluent ..
  76. pmc Brain atrophy correlates with functional outcome in a murine model of multiple sclerosis
    I Pirko
    Mayo Clinic, Department of Neurology, College of Medicine, Rochester, MN 55905, USA
    Neuroimage 54:802-6. 2011
    ..Unlike lesion based measures, volumetric MRI assessment of brain atrophy shows a strong correlation with functional outcome, and the presence of early atrophy predicts a worse disease ..
  77. pmc Alzheimer's disease pattern of brain atrophy predicts cognitive decline in Parkinson's disease
    Daniel Weintraub
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 3339, USA
    Brain 135:170-80. 2012
    ..To assess the clinical significance of this, we applied a validated Alzheimer's disease-spatial pattern of brain atrophy to patients with Parkinson's disease with a range of cognitive abilities to determine its association with ..
  78. pmc Cerebral tissue repair and atrophy after embolic stroke in rat: a magnetic resonance imaging study of erythropoietin therapy
    Guangliang Ding
    Department of Neurology, Henry Ford Hospital, Detroit, MI 48202, USA
    J Neurosci Res 88:3206-14. 2010
    ..increased after EPO treatment compared with control animals, indicating that EPO significantly reduces atrophy of the ipsilateral hemisphere, although no significant differences in ischemic lesion volume were observed ..
  79. pmc Depressive symptoms in mild cognitive impairment predict greater atrophy in Alzheimer's disease-related regions
    Grace J Lee
    Department of Neurology, David Geffen School of Medicine at University of California Los Angeles, USA
    Biol Psychiatry 71:814-21. 2012
    ..Thus, we examined the neuroanatomical changes associated with depressive symptoms in MCI...
  80. ncbi Direct voxel-based comparison between grey matter hypometabolism and atrophy in Alzheimer's disease
    G Chetelat
    Inserm EPHE Universite de Caen Basse Normandie, Unité E0218 U923, Laboratoire de Neuropsychologie, GIP Cyceron, CHU Cote de Nacre, Caen, France
    Brain 131:60-71. 2008
    ..disease are being refined and discrepancies between them are being underlined, the exact relationships between atrophy and hypometabolism are still unclear...
  81. pmc Intellectual enrichment lessens the effect of brain atrophy on learning and memory in multiple sclerosis
    James F Sumowski
    Neuropsychology and Neuroscience Laboratory, Kessler Foundation Research Center, Suite 10, West Orange, NJ 07052, USA
    Neurology 74:1942-5. 2010
    ..with multiple sclerosis (MS); however, such deficits are only weakly associated with MS disease severity (brain atrophy)...
  82. pmc Baseline MRI predictors of conversion from MCI to probable AD in the ADNI cohort
    Shannon L Risacher
    IU Center for Neuroimaging, Division of Imaging Sciences, Department of Radiology, Indiana University School of Medicine, 950 W Walnut St, R2 E124, Indianapolis, IN 46202, USA
    Curr Alzheimer Res 6:347-61. 2009
    ..Validation of imaging biomarkers is important as they can help enrich clinical trials of disease modifying agents by identifying individuals at highest risk for progression to AD...
  83. ncbi Differential regional atrophy of the cingulate gyrus in Alzheimer disease: a volumetric MRI study
    Bethany F Jones
    Department of Neurology, VU University Medical Centre, Amsterdam, The Netherlands
    Cereb Cortex 16:1701-8. 2006
    ..imaging-based volumetric measurements provide a useful technique for quantifying in vivo regional cerebral atrophy in Alzheimer disease (AD)...
  84. pmc Baseline and longitudinal patterns of brain atrophy in MCI patients, and their use in prediction of short-term conversion to AD: results from ADNI
    Chandan Misra
    Department of Radiology, Section of Biomedical Image Analysis, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Neuroimage 44:1415-22. 2009
    ..whereas they were positive in almost all MCI converters (MCI-C), indicating extensive patterns of AD-like brain atrophy in almost all MCI-C. Both MCI subgroups had similar MMSE scores at baseline...
  85. ncbi Distribution of grey matter atrophy in Huntington's disease patients: a combined ROI-based and voxel-based morphometric study
    G Douaud
    URA CNRS CEA 2210, Service Hospitalier Frederic Joliot, 4, place du General Leclerc, 91 401 Orsay, and Département de Neurologie, CHU Angers, France
    Neuroimage 32:1562-75. 2006
    ..The measurement of striatal atrophy using the bicaudate ratio on CT scanner images has therefore been used for years to assess disease progression, ..
  86. ncbi Normalized accurate measurement of longitudinal brain change
    S M Smith
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, England
    J Comput Assist Tomogr 25:466-75. 2001
    Quantitative measurement of change in brain size and shape (e.g., to estimate atrophy) is an important current area of research. New methods of change analysis attempt to improve robustness, accuracy, and extent of automation...
  87. ncbi Hippocampal volume and asymmetry in mild cognitive impairment and Alzheimer's disease: Meta-analyses of MRI studies
    Feng Shi
    National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China
    Hippocampus 19:1055-64. 2009
    ..In this article, meta-analyses are designed to determine the extent of hippocampal atrophy in MCI and AD, and to evaluate the asymmetry pattern of the hippocampal volume in control, MCI, and AD groups...
  88. ncbi Cyclooxygenase-2 is up-regulated in proliferative inflammatory atrophy of the prostate, but not in prostate carcinoma
    S Zha
    Graduate Program of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer Res 61:8617-23. 2001
    ..tumor and normal tissue regions but was much more consistently observed in areas of proliferative inflammatory atrophy, lesions that have been implicated in prostatic carcinogenesis. Staining was also seen at times in macrophages...
  89. pmc Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease
    Clifford R Jack
    Clifford R Jack, Mayo Clinic, Diagnostic Radiology, 200 First Street SW, Rochester, MN 55905, USA
    Brain 132:1355-65. 2009
    ..PIB retention was quantified in global cortical to cerebellar ratio units and brain atrophy in units of cm(3) by measuring ventricular expansion...
  90. pmc Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy
    Jeffrey J Brault
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 285:19460-71. 2010
    ..gamma coactivator 1alpha (PGC-1alpha), like exercise, increases mitochondrial content and inhibits muscle atrophy. To understand these actions, we tested whether PGC-1alpha or its close homolog, PGC-1beta, influences muscle ..
  91. pmc Atrophy patterns in histologic vs clinical groupings of frontotemporal lobar degeneration
    J M S Pereira
    Department of Clinical Neurosciences, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Neurology 72:1653-60. 2009
    Predictable patterns of atrophy are associated with the clinical subtypes of frontotemporal dementia (FTD): behavioral variant (bvFTD), semantic dementia (SEMD), and progressive nonfluent aphasia (PNFA)...
  92. ncbi Patterns of temporal lobe atrophy in semantic dementia and Alzheimer's disease
    D Chan
    Department of Clinical Neurology, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
    Ann Neurol 49:433-42. 2001
    ..magnetic resonance imaging analyses of 30 subjects were undertaken to quantify the global and temporal lobe atrophy in semantic dementia and Alzheimer's disease...
  93. pmc 3D maps from multiple MRI illustrate changing atrophy patterns as subjects progress from mild cognitive impairment to Alzheimer's disease
    Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
    Brain 130:1777-86. 2007
    ..The aim of this study was to assess the progression of cerebral atrophy over multiple serial MRI during the period from aMCI to progression to AD...
  94. pmc Automated 3D mapping of hippocampal atrophy and its clinical correlates in 400 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls
    Jonathan H Morra
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
    Hum Brain Mapp 30:2766-88. 2009
    ..84; SD: 6.64). Hippocampal traces were converted to parametric surface meshes and a radial atrophy mapping technique was used to compute average surface models and local statistics of atrophy...
  95. ncbi Posterior cingulate cortex atrophy and regional cingulum disruption in mild cognitive impairment and Alzheimer's disease
    Il Han Choo
    Department of Neuropsychiatry and Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    Neurobiol Aging 31:772-9. 2010
    This study aimed to investigate the atrophy of the posterior cingulate cortex (PCC) and medical temporal lobe (MTL) structures (i.e...
  96. pmc Spatial patterns of brain amyloid-beta burden and atrophy rate associations in mild cognitive impairment
    Duygu Tosun
    Center for Imaging Neurodegenerative Diseases, Department of Veterans Affairs Medical Centre, 4150 Clement Street, Building 13, 114 M, San Francisco, CA 94121, USA
    Brain 134:1077-88. 2011
    ..decline, suggesting that events in the brain downstream from amyloid-β deposition, such as regional brain atrophy rates, play an important role...
  97. ncbi Brain atrophy in clinically early relapsing-remitting multiple sclerosis
    D T Chard
    NMR Research Unit, Department of Clinical Neurology, Institute of Neurology, University College London, UK
    Brain 125:327-37. 2002
    Brain atrophy measured by MRI is a potentially useful tool for monitoring disease progression in multiple sclerosis. The location, extent and mechanisms of brain atrophy in early disease are not well documented...
  98. ncbi Why voxel-based morphometry should be used
    J Ashburner
    The Wellcome Department of Cognitive Neurology, Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
    Neuroimage 14:1238-43. 2001
    ..We first review the tenets of VBM, paying particular attention to the relationship between VBM and tensor-based morphometry. The last two sections of this response deal with the specific concerns raised by Dr. Bookstein...
  99. ncbi Anatomically-distinct genetic associations of APOE epsilon4 allele load with regional cortical atrophy in Alzheimer's disease
    Nicola Filippini
    The Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, UK
    Neuroimage 44:724-8. 2009
    ..Our aim was to define the relationship between APOE epsilon4 allele load and regionally-specific brain cortical atrophy in Alzheimer's Disease (AD)...
  100. pmc Sequential relationships between grey matter and white matter atrophy and brain metabolic abnormalities in early Alzheimer's disease
    Nicolas Villain
    Inserm EPHE Universite de Caen Basse Normandie, Unité U923, GIP Cyceron, Bd H Becquerel, BP 5229, 14074 Caen Cedex, France
    Brain 133:3301-14. 2010
    Hippocampal atrophy, posterior cingulate and frontal glucose hypometabolism, and white-matter tract disruption are well described early macroscopic events in Alzheimer's disease...
  101. ncbi Neocortical atrophy, third ventricular width, and cognitive dysfunction in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, School of Medicine, State University of New York at Buffalo, 100 High Street, Buffalo, NY 14203, USA
    Arch Neurol 63:1301-6. 2006
    Cognitive dysfunction is common in multiple sclerosis (MS). Correlations are reported between atrophy and neuropsychological test results.

Research Grants78

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Title: Pilot Study of the Evaluation of Intravitreal Sirolimus in the Treatment of Bilateral Geographic Atrophy Associated with Age-Related Macular Degeneration Number: 11-EI-0249 Summary: Background: - Age-related macular ..
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Title: Pilot Study of the Evaluation of Intravitreal Sirolimus in the Treatment of Bilateral Geographic Atrophy Associated with Age-Related Macular Degeneration Number: 11-EI-0249 Summary: Background: - Age-related macular ..
  3. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
  4. Agrin/alpha 3 Na,K-ATPase signaling at the neuromuscular junction
    Martin A Smith; Fiscal Year: 2012
    ..Disruption of this system by disease, as occurs in various myasthenic disorders, spinal muscular atrophy, and amyotrophic lateral sclerosis, toxins such as botulinum toxin, or traumatic injury, results in muscle ..
  5. Sphingolipid Metabolism in Drosophila Development
    Julie D Saba; Fiscal Year: 2013
    ..cell biology;2) To dissect the role of SPL in muscle development;and 3) To establish the role of SPL in muscle atrophy and regeneration...
  6. Mechanisms of action of ghrelin in muscle and adipose tissue in cancer-related ca
    Jose M Garcia; Fiscal Year: 2013
    ..model of cisplatin-induced cachexia we have observed that ghrelin prevents cisplatin-induced fat and muscle atrophy. We are now proposing to determine the mechanisms involved in this setting and further characterize these ..
  7. Regulation of epithelial cell homeostasis by actin microfilaments
    Seema Khurana; Fiscal Year: 2010
    ..Defects in apoptosis are associated with several gastrointestinal conditions including villus atrophy, epithelial hyperplasia, loss of normal absorptive function and increased risk of tumorigenesis...
  8. BIOCHEMISTRY OF PRE-MRNA SPLICING
    Adrian R Krainer; Fiscal Year: 2010
    ..Some of these approaches are already being tested in clinical trials for muscular dystrophy and spinal muscular atrophy, while others are still in the pre-clinical stages...
  9. Genetic Studies of Optic Atrophy
    Taosheng Huang; Fiscal Year: 2012
    Optic atrophy gene 1 (OPA1) is a nuclear gene encoding a mitochondrial protein. Mutation of OPA1 is the most common cause for autosomal dominant optic atrophy (DOA)...
  10. Genetics of the Neuromuscular Junction: Mechanisms and Disease Models
    Robert W Burgess; Fiscal Year: 2013
    ..CMT2D patients may present with purely motor deficits (diagnosed as distal Spinal Muscular Atrophy type V, dSMAV), whereas others carrying the same mutation present with both motor and sensory deficits...
  11. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2011
    ..by drastic side effects such as diabetes mellitus, peptic ulcer, Cushing's syndrome, osteoporosis, skin atrophy, psychosis, glaucoma, and many others upon chronic use...
  12. Ca Signaling in Progression of Amyotrophic Lateral Sclerosis in Skeletal Muscle
    Jingsong Zhou; Fiscal Year: 2013
    ..lateral sclerosis (ALS) is a progressive neuromuscular disorder involving degeneration of motor neurons and atrophy of skeletal muscle...
  13. Misty: a model for central regulation of bone remodeling
    CLIFFORD JAMES ROSEN; Fiscal Year: 2013
    ..In addition, aging also profoundly affects adipose tissue through atrophy of preformed brown adipose tissue (BAT), lipid deposition in non-adipose sites, and changes in white adipose ..
  14. A Ribozyme Rescue Strategy for Dry Age-Related Macular Degeneration
    John M Sullivan; Fiscal Year: 2013
    ..would act to preserve overlying PRs, maintain central vision, and slow or halt emergence of geographic macular atrophy. The long term objective is to develop a safe and effective gene therapy for dAMD/JMD...
  15. Role of Dendritic Ca2+ Transients in Respiratory Rhythm Generation
    Jack L Feldman; Fiscal Year: 2010
    ..Various neurodegenerative diseases, such as Parkinson's disease, multiple systems atrophy and amyotrophic lateral sclerosis, are associated with sleep disordered breathing that we hypothesize results ..
  16. Role of troponin T isoforms in nemaline myopathy
    Jian Ping Jin; Fiscal Year: 2012
    ..TnT knockdown mouse model in which lowered slow TnT gene expression results in decreased slow TnT protein, muscle atrophy and a switch to fast fiber phenotypes with decreased tolerance to fatigue...
  17. Nutrition and Anabolic Interventions in Cancer Cachexia
    Melinda Sheffield-Moore; Fiscal Year: 2013
    ..mass and muscle strength, 2) muscle protein turnover, and 3) inflammatory biomarkers and signaling pathways of atrophy in skeletal muscle...
  18. Reversing Corticosteroid-Induced Memory Impairment
    E Sherwood Brown; Fiscal Year: 2013
    ..The human literature is quite limited. However, impairment in declarative memory and hippocampal atrophy, have been reported in patients with corticosteroid excess due to Cushing's disease, and, more recently by ..
  19. Markers of Renal Damage in Renovascular Hypertension
    Juan C Romero; Fiscal Year: 2011
    ..aim tests the hypothesis that the efficacy of PTRA to restore renal function is determined by a) the degree of atrophy and functional decline in the ST-KD;b) the amount of ST-KD function that has been transferred to CONT-KD;c) the ..
  20. Muscle stem cell therapy in a mouse model of premature aging
    Johnny Huard; Fiscal Year: 2010
    ..pathologies including ataxia, kyphosis, cachexia, disc degeneration, osteoporosis, incontinence, epidermal atrophy, sarcopenia, bone marrow degeneration and liver as well as kidney dysfunction...
  21. High-affinity RNA targets of Survival Motor Neuron Protein
    Ravindra N Singh; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Spinal muscular atrophy (SMA) is a developmental disorder characterized by a progressive loss of motor neurons during early childhood...
  22. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2013
    ..by drastic side effects such as diabetes mellitus, peptic ulcer, Cushing's syndrome, osteoporosis, skin atrophy, psychosis, glaucoma, and many others upon chronic use...
  23. Intravenous Protein Therapy for Myotonic Dystrophy Type 1
    Richard Weisbart; Fiscal Year: 2010
    ..account for the observed phenotype in DM1;including muscle wasting and myotonia, insulin resistance, testicular atrophy, cutaneous tumors cardiac arrhythmia and cognition defects (4- 8)...
  24. Mitochondrial Oxidative Stress in the Retinal Pigment Epithelium as a Model for A
    Alfred S Lewin; Fiscal Year: 2013
    ..cells and by stimulating an inflammatory cascade that leads to the pathologic hallmarks of the disease, localized atrophy of the retina and choroidal neovascularization...
  25. Klotho regulation and aging
    Gwendalyn D King; Fiscal Year: 2010
    ..in aged humans (cognitive impairment, atherosclerosis, ectopic calcification, emphysema, osteoporosis, skin atrophy and hair loss, thymic involution, infertility and decreased bone mineral density)...
  26. REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORI
    Yoshio Yamaoka; Fiscal Year: 2013
    ..is induced early and results in inflammation and ulceration whereas NF- B and ISRE are induced late and result in atrophy). Our previous results are based on analysis of the whole gastric mucosa...
  27. Innate Immune Mechanisms of Motor Neuron Injury
    Timothy Vartanian; Fiscal Year: 2010
    ..such as Primary Lateral Sclerosis, pure Hereditary Spastic Paraplegia, Kennedy's disease, Spinal Muscular Atrophy, Progressive Muscular Atrophy, and amyotrophic lateral sclerosis, as well as in viral diseases such as Polio, HIV,..
  28. Mechanisms of tubular atrophy in renal disease
    Jeffrey R Schelling; Fiscal Year: 2012
    ..However, progression to end stage is more tightly coupled to proximal tubule disappearance (tubular atrophy), which is caused by apoptosis...
  29. Muscle Wasting in Uremia
    Ralph Rabkin; Fiscal Year: 2012
    ..Preliminary data indicate that disuse atrophy may be exaggerated in CKD and that recovery may be impaired...
  30. In vivo analysis of the mechanisms of axon transport.
    Catherine M Drerup; Fiscal Year: 2011
    ..in this process are associated with numerous developmental and neurodegenerative diseases such as Spinal Muscular Atrophy, Alzheimer's Disease, and Amyotrophic Lateral Sclerosis...
  31. Analysis of the tumor suppressor gene Tsc1 in motor neuron patterning
    Onanong Chivatakarn; Fiscal Year: 2013
    ..locomotion, respiration and autonomic responses, and are profoundly affected by diseases such as spinal muscle atrophy (SMA) and amyotrophic lateral sclerosis (ALS)...
  32. Dysfunctional PGC-1alpha expression in skeletal muscle during diabetes
    S Russ Price; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Skeletal muscle atrophy is a frequent co-morbidity of diabetes mellitus (DM) and other chronic diseases that causes fatigue and weakness...
  33. Investigating the role of interleukin-22 in thymus function
    Jarrod Dudakov; Fiscal Year: 2013
    ..and (d) breakdown of IL-22 regenerative pathways underlie chronic thymic involution, including age-related atrophy. Exploring the functional translation of IL-22-mediated regeneration is a natural progression of my postdoctoral ..
  34. REGULATION OF ATROPHY-INDUCED PROGENITOR CELLS IN THE GASTRIC CORPUS
    Jason C Mills; Fiscal Year: 2013
    ..Within 6 hours, parietal cells begin to die (atrophy), and progenitor cells in the isthmal stem cel niche of corpus gastric units begin to expand in response...
  35. The Role of RNA Splicing Factors in Retinal Degeneration
    Michael Farkas; Fiscal Year: 2012
    ..In this case, the neurologic disorder spinal muscular atrophy (SMA), which is caused by mutations in the survival motor neurons (SMN) gene...
  36. Noncoding RNA targets of the spinal muscular atrophy protein
    Livio Pellizzoni; Fiscal Year: 2010
    ..recessive disorder characterized by degeneration of motor neurons in the spinal cord and skeletal muscle atrophy. SMA is the leading genetic cause of death in infancy for which no effective treatment is currently available...
  37. AGE-RELATED ALTERATION OF LEYDIG CELL REDOX ENVIRONMENT A RISK FACTOR FOR SUSCEPT
    Kassim Traore; Fiscal Year: 2013
    ..to DEHP have been shown to result in reduced litter size, and, later in life, Leydig cell hyperplasia, testicular atrophy, reduced serum levels of seru testosterone, and reduced fertility...
  38. IL-22 in Thymic Regeneration
    Marcel R m van den Brink; Fiscal Year: 2013
    ..not only for recipients of allo-HSCT, but also for individuals with T cell deficiencies due to aging (lymphoid atrophy), autoimmune diseases, infectious diseases, shock, radio- or chemo-therapy and radiation injury (nuclear accident ..
  39. Testing Compounds that Increase SMN levels for Efficacy in Mouse Models of SMA
    Elliot J Androphy; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Spinal muscular atrophy (SMA) is an autosomal recessive form of muscular dystrophy that afflicts approximately 1 in 6,000 live births and clinically manifests as progressive muscle weakness due to ..
  40. Identification and Validation of Alcohol Biomarker Signatures by Proteomics
    Emanuel Rubin; Fiscal Year: 2010
    ..Alcoholism also causes atrophy of skeletal muscle, termed alcoholic myopathy, which is closely correlated with ACM...
  41. Harness Germinal Matrix Hemorrhage
    John H Zhang; Fiscal Year: 2013
    ..Debilitating consequences of GMH include the formation of post- hemorrhagic hydrocephalus, leading to brain atrophy and neurological impairments...
  42. Optimization of HDAC6 Inhibitors in the Treatment of CMT
    Ludo Van Den Bosch; Fiscal Year: 2013
    ..CMT, also known as hereditary motor and sensory neuropathy (HMSN) or peroneal muscular atrophy, is made up of a group disorders that affect peripheral nerves. CMT affects both motor and sensory nerves...
  43. Gq-coupled Receptors Inhibit PI 3-kinase/Akt Signaling Pathway
    Richard Z Lin; Fiscal Year: 2012
    ..Aim 3 investigates if ablation of p110alpha or p110beta affects skeletal muscle atrophy caused by hindlimb unloading or muscle regrowth following reambulation...
  44. Rocker Shoes for Natural Immobilization of the Ankle during Single Limb Support
    Andrew H Hansen; Fiscal Year: 2012
    ..the use of walking casts or boots reduce the need for muscular contractions across the ankle joint, leading to atrophy and weakness of the leg muscles...
  45. SPLICING OF MRNA PRECURSORS
    Michael R Green; Fiscal Year: 2013
    ..result in a variety of human diseases including atypical cystic fibrosis, retinitis pigmentosa, spinal muscular atrophy and facioscapulohumeral muscular dystrophy, and has also been associated with cancer and metastasis...
  46. C/EBP, atrogin-1, and muscle wasting
    Per Olof Hasselgren; Fiscal Year: 2009
    ..The role of p300 and C/EBP[unreadable] in sepsis- and dexamethasone-induced muscle proteolysis, atrophy, and atrogin1 and MuRF1 expression is tested by transfecting rat extensor digitorum longus muscle or cultured ..
  47. Identification of stromal responses during castration-induced thymic regrowth.
    Howard T Petrie; Fiscal Year: 2013
    ..Because the output of new T cells from the thymus is directly proportional to its mass, age-related thymic atrophy results in a lifelong, progressive decline in the production of new, naive T cells...
  48. Longitudinal Study of Lipids and APOE in the Development of AD and AD Pathology
    Michelle M Mielke; Fiscal Year: 2013
    ..decline in tests of memory;2) incident MCI, all-cause dementia, and AD;3) change in serial MRI measures of brain atrophy and white matter lesion burden over 10 years;and 4) amyloid-beta deposition on 11C-PIB PET scans...
  49. Small Oligonucleotides As Therapeutic Agents Of Spinal Muscular Atrophy
    Ravindra N Singh; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Spinal Muscular Atrophy (SMA) is a leading genetic cause of infant mortality...
  50. The survival of motor neuron protein in axonal mRNA localization
    PAUL GREGORY DONLIN-ASP; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Spinal muscular atrophy (SMA) is the leading genetic cause of infant mortality and the second most common autosomal recessive genetic disorder worldwide...
  51. A Spontaneous Mouse Model of Motor Neuron Disease
    Kevin L Seburn; Fiscal Year: 2011
    ..a motor neuron disease in mice that directly led to the identification of the genetic basis of Spinal Muscular Atrophy with Respiratory Distress in humans...
  52. REACTIVE OXYGEN SPECIES: STRESS AND DAMAGE IN OLD MUSCLE
    Susan V Brooks; Fiscal Year: 2012
    ..neurons, skeletal muscle fibers and mitochondria that cause acceleration in the development of age-related muscle atrophy and weakness...
  53. Klotho regulation and aging
    GWENDALYN DIANN KING; Fiscal Year: 2013
    ..in aged humans (cognitive impairment, atherosclerosis, ectopic calcification, emphysema, osteoporosis, skin atrophy and hair loss, thymic involution, infertility and decreased bone mineral density)...
  54. Mitochondrial Inborn Errors in Metabolism
    Douglas C Wallace; Fiscal Year: 2013
    ..years of development we have succeeded in isolating in the mouse mtDNA a mutation that is known to cause optic atrophy in humans (ND6 P25L) and in introducing this mtDNA mutation into the mouse female germ line in the homoplasmic ..
  55. Cerebrovascular Disease and its Consequences in the Strong Study Cohort
    Dedra S Buchwald; Fiscal Year: 2013
    ..defined by brain MRI findings, specifically white matter hyperintensities, infarcts, hemorrhages, and cerebral atrophy;2) assess the relationship of risk factors with prevalent MRI-defined CBVD such as demographic, lifestyle, ..
  56. Development of novel therapies for aging-induced skeletal muscle atrophy.
    SCOTT MATTHEW EBERT; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aging-induced skeletal muscle atrophy, also known as sarcopenia, affects approximately 30 million people in the United States, often leading to weakness, reduced quality-of-life, falls, fractures, ..
  57. Molecular and Cellular Regulation of Mammalian Renal Medulla Development
    Jing Yu; Fiscal Year: 2013
    ..Renal medulla atrophy is a prominent symptom of hydronephrosis, a common condition occurs in approximately 1 in 100 people and a ..
  58. Function of the Zinc Finger Protein ZPR1 in neurodegeneration
    LAXMAN DASS GANGWANI; Fiscal Year: 2013
    ..is to understand the physiological role of zinc finger protein ZPR1 in the pathogenesis of spinal muscular atrophy (SMA) caused by mutation of the survival motor neurons (SMN1) gene...
  59. Non-Human Primate Model of Gluten-Sensitive Enteropathy
    Karol Sestak; Fiscal Year: 2013
    ..presence of AGA, anti-transglutaminase 2 (TG2) antibodies, villous atrophy, increased presence of IELs and inflammatory-cytokine producing intestinal T lymphocytes in macaques with ..
  60. Role of Stasimon Dysfunction in Spinal Muscular Atrophy
    Livio Pellizzoni; Fiscal Year: 2013
    Project Summary Spinal muscular atrophy (SMA) is an inherited neurodegenerative disease characterized by motor neuron loss and skeletal muscle atrophy...
  61. QUANTITATIVE ANALYSIS OF AGING RETINA
    Christine A Curcio; Fiscal Year: 2012
    ..Project MACULA (Maculopathy Unveiled by Laminar Analysis) will use aged normal, early ARM, geographic atrophy, and neovascular ARM to: 1...
  62. Mechanisms Involved in Age-Related Loss of Muscle Mass and Growth Response
    SUE CAROL BODINE; Fiscal Year: 2012
    ..the resistance of muscle to grow in response to increased loading and nutrition following disuse-induced atrophy. Our working hypothesis is that the age-associated loss of load-induced muscle growth is the result of increased ..
  63. Cooperative lead development program for treatment of spinal muscular atrophy
    Elliot J Androphy; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Spinal Muscular Atrophy (SMA) is a common form of muscular dystrophy and the leading genetic cause of infant mortality...
  64. EMPHYSEMA--INFLUENCES ON DIAPHRAGM FATIGUE RESISTANCE
    Michael Lewis; Fiscal Year: 1992
    ..in chronic obstructive pulmonary disease (COPD) resulting in altered diaphragmatic strength and endurance, due to atrophy of fast- twitch muscle fibers corticosteroids, which are often used in COPD, also causes as well as a decrease in ..
  65. Acute Nutritional Deprivation: Diaphragm Influences
    Michael Lewis; Fiscal Year: 2007
    ..improved understanding of potential molecular targets in the management of disordered protein turnover and muscle atrophy in the diaphragm of a clinically relevant animal model of severe short-term nutritional deprivation (ND)...
  66. MECHANICAL VENTILATION AND RESPIRATORY MUSCLES
    Scott Powers; Fiscal Year: 2004
    ..Indeed, we have recently demonstrated that prolonged MV results in diaphragmatic atrophy and a significant reduction in diaphragmatic maximal force production...
  67. CLINICAL TRIALS FOR PEDIATRIC SPINAL MUSCULAR ATROPHY
    Susan Iannaccone; Fiscal Year: 2005
    DESCRIPTION (provided by the applicant): Spinal muscular atrophy (SMA) is a genetic disease, frequency 8 per 100,000 live births, with a high mortality during infancy and no known treatment...
  68. Animal models to examine role of ZPR1 protein complexes
    LAXMAN DASS GANGWANI; Fiscal Year: 2010
    ..of diverse human genetic diseases ranging from cancer to neurodegenerative disorders, including spinal muscular atrophy (SMA)...
  69. Role of Musculo-Dynamics in Bone Fluid Flow, Circulation and Adaptation
    Yi Xian Qin; Fiscal Year: 2009
    ..g., bedrest and microgravity), have significant physiological effects in muscle atrophy and osteopenia. Exercise such as muscle contraction appears to increase blood flow to the skeletal tissues, i.e...
  70. Aging, AMP Kinase and Skeletal Muscle Overload
    Scott Gordon; Fiscal Year: 2005
    Significant skeletal muscle atrophy results in a loss of functional independence and quality of life, and interventions such as resistance exercise training are not fully effective in restoring muscle mass in elderly individuals...
  71. Intercellular Signaling in Obstructive Nephropathy
    ROBERT CHEVALIER; Fiscal Year: 2005
    ..obstruction (UUO) are dependent on the balance between two nephron populations: those undergoing progressive atrophy, and those that maintain structural integrity and function...
  72. GYRATE ATROPHY-MODEL FOR MOLECULAR STUDY OF EYE DISEASES
    George Inana; Fiscal Year: 1991
    ..Among the various inherited retinal degenerative diseases that lead to blindness in man, gyrate atrophy (GA) serves as a unique model because knowledge of the underlying biochemical defect, i.e...
  73. Motoneuron-selective Rescue of SMA Model Mice
    Mendell Rimer; Fiscal Year: 2012
    ..provided by applicant): Lower motoneuron death is believed to be the primary defect in spinal muscular atrophy (SMA), a childhood hereditary neuromuscular disease almost as prevalent as cystic fibrosis, perhaps the best-..
  74. Attenuation of denervation atrophy by nandrolone: molecular mechanisms
    Christopher Cardozo; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Androgenic steroids reduce muscle atrophy through molecular mechanisms that are poorly understood...
  75. PROPOSED RAT MODEL OF OLIVOPONTOCEREBELLAR ATROPHY
    CHERYL GUYER; Fiscal Year: 2000
    Olivopontocerebellar atrophy (OPCA) is one entity in a diverse group of familial, progressive, neurodegenerative disorders in man and animals that is characterized by variable atrophy of the cerebellum, basis pontis, and olivary nuclei...
  76. Large Animal Model of Spinal Muscular Atrophy
    MONIQUE LORSON; Fiscal Year: 2009
    ..Project summary/abstract: This application proposes the generation of a swine model of Spinal Muscular Atrophy (SMA) (pSMN1-/-;hSMN2) using somatic cell nuclear transfer of gene targeted fetal fibroblasts and breeding...
  77. NON-INVASIVE MEASUREMENT OF RPE LIPOFUSCIN
    Francois DeLori; Fiscal Year: 2005
    ..Its hallmarks are neovascularization and/or atrophy of photoreceptors and retinal pigment epithelial cells (RPE)...
  78. Novel Gene Delivery Development for Spinal Muscular Atrophy
    Brian Kaspar; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Spinal muscular atrophy (SMA) is a genetic disorder characterized by the loss of lower motor neurons (LMNs) residing along the entire length of the spinal cord...