croup

Summary

Summary: A condition characterized by resonant barking cough, hoarseness and persistant stridor and caused by allergy, foreign body, infection, or neoplasm. It occurs chiefly in infants and children.

Top Publications

  1. ncbi Viral croup: a current perspective
    Alexander K C Leung
    Department of Pediatrics, University of Calgary and the Alberta Children s Hospital, Canada
    J Pediatr Health Care 18:297-301. 2004
  2. ncbi Budesonide offers no advantage when added to oral dexamethasone in the treatment of croup
    Gary Cornelis Geelhoed
    Emergency Department, Princess Margaret Hospital for Children, Perth, WA, Australia
    Pediatr Emerg Care 21:359-62. 2005
  3. ncbi Outpatient treatment of moderate croup with dexamethasone: intramuscular versus oral dosing
    K K Rittichier
    Primary Children s Medical Center, University of Utah, Salt Lake City, Utah, USA
    Pediatrics 106:1344-8. 2000
  4. ncbi Comparison between single-dose oral prednisolone and oral dexamethasone in the treatment of croup: a randomized, double-blinded clinical trial
    Allison A Fifoot
    Department of Emergency Medicine, Royal Brisbane and Women s Hospital, Brisbane, Queensland, Australia
    Emerg Med Australas 19:51-8. 2007
  5. ncbi A comparison of nebulized budesonide, and intramuscular, and oral dexamethasone for treatment of croup
    Feyzullah Cetinkaya
    Pediatrician and Pediatric Allergist in Sisli Etfal Education and Research Hospital, Istanbul, Turkey
    Int J Pediatr Otorhinolaryngol 68:453-6. 2004
  6. ncbi Effectiveness of oral or nebulized dexamethasone for children with mild croup
    J W Luria
    Division of Emergency Medicine, Children s Hospital Medical Center, 3333 Burnet Ave OSB 4, Cincinnati, OH 45229 3039, USA
    Arch Pediatr Adolesc Med 155:1340-5. 2001
  7. ncbi The effect of epinephrine by nebulization on measures of airway obstruction in patients with acute severe croup
    A C Argent
    Division of Paediatric Critical Care and Children s Heart Disease, Red Cross War Memorial Children s Hospital and University of Cape Town, Rondebosch, 7700 Cape Town, South Africa
    Intensive Care Med 34:138-47. 2008
  8. ncbi Oral betamethasone versus intramuscular dexamethasone for the treatment of mild to moderate viral croup: a prospective, randomized trial
    Lisa Amir
    Unit of Emergency Medicine, Schneider Children s Medical Center of Israel, Petah Tiqva, Israel
    Pediatr Emerg Care 22:541-4. 2006
  9. ncbi The mechanics of breathing in children with acute severe croup
    Andrew C Argent
    University of Cape Town, Division of Paediatric Critical Care and Children s Heart Disease, School of Child and Adolescent Health, Cape Town, South Africa
    Intensive Care Med 34:324-32. 2008
  10. ncbi Clinical practice. Croup
    James D Cherry
    Division of Infectious Diseases, Mattel Children's Hospital UCLA, and the Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1752, USA
    N Engl J Med 358:384-91. 2008

Research Grants

  1. Mechanisms of viral proteases in coronavirus replication and pathogenesis
    Andrew D Mesecar; Fiscal Year: 2010
  2. Glycoprotein interactions in paramyxovirus fusion
    Ronald M Iorio; Fiscal Year: 2010
  3. Glycoprotein interactions in paramyxovirus fusion
    RONALD IORIO; Fiscal Year: 2007
  4. A Simulator for Sound Production in Airways
    Ingo R Titze; Fiscal Year: 2010
  5. A Simulator for Sound Production in Airways
    Ingo Titze; Fiscal Year: 2007
  6. A Simulator for Sound Production in Airways
    Ingo Titze; Fiscal Year: 2009
  7. HOST VIRUS INTERACTION AND GENE EXPRESSION
    Amiya Banerjee; Fiscal Year: 1993
  8. MOLECULAR BASIS FOR PARAINFLUENZA 3 INFECTION
    Anne Moscona; Fiscal Year: 2002
  9. Pulsus Paradoxus Monitor
    Gregory Jay; Fiscal Year: 2005
  10. Developing Quality Measures to Assess Pediatric Inpatient Respiratory Care
    Rita Mangione Smith; Fiscal Year: 2010

Detail Information

Publications159 found, 100 shown here

  1. ncbi Viral croup: a current perspective
    Alexander K C Leung
    Department of Pediatrics, University of Calgary and the Alberta Children s Hospital, Canada
    J Pediatr Health Care 18:297-301. 2004
    Viral croup is the most common cause of upper airway obstruction in children 6 months to 6 years of age. Parainfluenza virus accounts for the majority of cases...
  2. ncbi Budesonide offers no advantage when added to oral dexamethasone in the treatment of croup
    Gary Cornelis Geelhoed
    Emergency Department, Princess Margaret Hospital for Children, Perth, WA, Australia
    Pediatr Emerg Care 21:359-62. 2005
    To evaluate the effect of adding inhaled budesonide (2 mg) to oral dexamethasone 0.15 mg/kg in children hospitalized with croup.
  3. ncbi Outpatient treatment of moderate croup with dexamethasone: intramuscular versus oral dosing
    K K Rittichier
    Primary Children s Medical Center, University of Utah, Salt Lake City, Utah, USA
    Pediatrics 106:1344-8. 2000
    Steroid use for the treatment of croup has been supported by several studies, although few have addressed the use of oral dexamethasone for outpatient management...
  4. ncbi Comparison between single-dose oral prednisolone and oral dexamethasone in the treatment of croup: a randomized, double-blinded clinical trial
    Allison A Fifoot
    Department of Emergency Medicine, Royal Brisbane and Women s Hospital, Brisbane, Queensland, Australia
    Emerg Med Australas 19:51-8. 2007
    To compare the effectiveness of three corticosteroid regimens in children with mild to moderate croup.
  5. ncbi A comparison of nebulized budesonide, and intramuscular, and oral dexamethasone for treatment of croup
    Feyzullah Cetinkaya
    Pediatrician and Pediatric Allergist in Sisli Etfal Education and Research Hospital, Istanbul, Turkey
    Int J Pediatr Otorhinolaryngol 68:453-6. 2004
    OBJECTIVES: Croup or acute laryngotracheobronchitis is the most common cause of the upper airway obstruction. Cool mist, nebulized racemic epinephrine and steroids are commonly used for therapy...
  6. ncbi Effectiveness of oral or nebulized dexamethasone for children with mild croup
    J W Luria
    Division of Emergency Medicine, Children s Hospital Medical Center, 3333 Burnet Ave OSB 4, Cincinnati, OH 45229 3039, USA
    Arch Pediatr Adolesc Med 155:1340-5. 2001
    To assess the efficacy of oral dexamethasone or nebulized dexamethasone sodium phosphate in children with mild croup.
  7. ncbi The effect of epinephrine by nebulization on measures of airway obstruction in patients with acute severe croup
    A C Argent
    Division of Paediatric Critical Care and Children s Heart Disease, Red Cross War Memorial Children s Hospital and University of Cape Town, Rondebosch, 7700 Cape Town, South Africa
    Intensive Care Med 34:138-47. 2008
    To demonstrate that tests of pulmonary function applicable to sick infants and small children with acute severe viral croup would provide clear, objective evidence of responsiveness to therapy with nebulized epinephrine.
  8. ncbi Oral betamethasone versus intramuscular dexamethasone for the treatment of mild to moderate viral croup: a prospective, randomized trial
    Lisa Amir
    Unit of Emergency Medicine, Schneider Children s Medical Center of Israel, Petah Tiqva, Israel
    Pediatr Emerg Care 22:541-4. 2006
    Intramuscular dexamethasone is an effective, but painful, treatment for croup. The effectiveness of betamethasone, an oral, palatable, and equally potent glucocorticoid has not been studied...
  9. ncbi The mechanics of breathing in children with acute severe croup
    Andrew C Argent
    University of Cape Town, Division of Paediatric Critical Care and Children s Heart Disease, School of Child and Adolescent Health, Cape Town, South Africa
    Intensive Care Med 34:324-32. 2008
    The assessment of the severity of croup and response to therapy has remained a clinical one...
  10. ncbi Clinical practice. Croup
    James D Cherry
    Division of Infectious Diseases, Mattel Children's Hospital UCLA, and the Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1752, USA
    N Engl J Med 358:384-91. 2008
  11. ncbi Nebulized budesonide and oral dexamethasone for treatment of croup: a randomized controlled trial
    T P Klassen
    Department of Pediatrics, University of Ottawa, Ontario, Canada
    JAMA 279:1629-32. 1998
    The effectiveness of glucocorticoids for patients with croup is well established but it remains uncertain which glucocorticoid regimen is most effective.
  12. ncbi Prednisolone versus dexamethasone in croup: a randomised equivalence trial
    A Sparrow
    Emergency Department, Princess Margaret Hospital for Children, Perth, Western Australia, Australia
    Arch Dis Child 91:580-3. 2006
    BACKGROUND: Croup remains a common respiratory problem presenting to emergency departments. A single oral treatment of oral dexamethasone results in improved outcome...
  13. ncbi A randomized comparison of dexamethasone 0.15 mg/kg versus 0.6 mg/kg for the treatment of moderate to severe croup
    S Chub Uppakarn
    Pediatric Division, Hatyai Hospital, Songkhla 90110, and Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hatyai, Thailand
    Int J Pediatr Otorhinolaryngol 71:473-7. 2007
    Although previous studies have shown that dexamethasone is useful in croup, the optimal dosage has not been clarified yet. The aim of this study was to investigate the effectiveness of dexamethasone 0...
  14. ncbi Humidified air inhalation for treating croup
    M Moore
    Three Swans Surgery, Rollestone Street, Salisbury, UK SP1 1DX
    Cochrane Database Syst Rev 3:CD002870. 2006
    b>Croup (laryngotracheobronchitis) is a common cause of upper airway obstruction in children with a peak incidence of 60 per 1000 child years in those aged between one and two years...
  15. ncbi New approaches to respiratory infections in children. Bronchiolitis and croup
    Robert Bruce Wright
    Division of Emergency Medicine, Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Emerg Med Clin North Am 20:93-114. 2002
    b>Croup is a disease that is commonly seen in children younger than the age of 6 years. The cause is viral, with parainfluenza viruses and RSV being the two most common pathogens...
  16. ncbi Croup is associated with the novel coronavirus NL63
    Lia van der Hoek
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS Med 2:e240. 2005
    ..We therefore determined its association with disease in young children with lower respiratory tract infection (LRTI)...
  17. ncbi A randomized trial of a single dose of oral dexamethasone for mild croup
    Candice L Bjornson
    Department of Pediatrics, University of Calgary, Calgary, Alta, Canada
    N Engl J Med 351:1306-13. 2004
    BACKGROUND: The benefits of dexamethasone treatment for moderate-to-severe croup are well established...
  18. ncbi Interactions of viral pathogens on hospital admissions for pneumonia, croup and chronic obstructive pulmonary diseases: results of a multivariate time-series analysis
    R E G Upshur
    Primary Care Research Unit, Sunnybrook and Women s College Health Sciences Centre, Toronto, ON, Canada
    Epidemiol Infect 134:1174-8. 2006
    ..0001). The use of multivariate time series and Granger causality applied to epidemiological data clearly illustrates the significant contribution of influenza and RSV to morbidity in the population...
  19. ncbi The management of croup
    Julie C Brown
    Division of General Academic Pediatrics, Department of Pediatrics, University of Washington School of Medicine, and Children's Hospital and Regional Medical Center, Seattle, Washington 98105-0371, USA
    Br Med Bull 61:189-202. 2002
    b>Croup is a common paediatric respiratory illness involving inflammation and narrowing of the subglottic region of the larynx, frequently precipitated by viral infections...
  20. ncbi Effectiveness of a croup clinical pathway in the management of children with croup presenting to an emergency department
    R Chin
    Department of Emergency Medicine, The Children's Hospital at Westmead, Royal Alexandra Hospital for Children, Westmead, New South Wales, Australia
    J Paediatr Child Health 38:382-7. 2002
    OBJECTIVE: The aim of this study was to evaluate the safety and effectiveness of a clinical pathway for croup in an emergency department (ED)...
  21. ncbi Practice variation in the emergency management of croup
    Louis C Hampers
    Section of Pediatric Emergency Medicine and the Children s Hospital Pediatric Urgent Care Network, Children s Hospital, Denver, Colorado 80218, USA
    Pediatrics 109:505-8. 2002
    To explore the effect of physician training background on the emergency management of croup.
  22. ncbi A randomized controlled trial of mist in the acute treatment of moderate croup
    Gina M Neto
    Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada
    Acad Emerg Med 9:873-9. 2002
    To determine whether the use of mist improves clinical symptoms in children presenting to the emergency department (ED) with moderate croup.
  23. ncbi A randomized comparison of helium-oxygen mixture (Heliox) and racemic epinephrine for the treatment of moderate to severe croup
    J E Weber
    Hurley Medical Center, Flint, Michigan, USA
    Pediatrics 107:E96. 2001
    To compare the additive effect of a helium-oxygen mixture (Heliox) or racemic epinephrine (RE) on croup scores (CSs) in children with moderate to severe croup treated with humidified oxygen and steroids. Design...
  24. ncbi Croup-treatment update
    Candice Leigh Bjornson
    Alberta Children's Hospital/University of Calgary, Canada
    Pediatr Emerg Care 21:863-70; quiz 871-3. 2005
  25. ncbi Acquired upper airway obstruction
    Jürg Hammer
    Division of Paediatric Intensive Care and Pulmonology, University Children s Hospital Basel, Romergasse 8, 4005 Basel, Switzerland
    Paediatr Respir Rev 5:25-33. 2004
    ..If respiratory failure is imminent, airway protection and endoscopy for definitive diagnosis may have priority over any other therapeutic or diagnostic procedure...
  26. ncbi How long does stridor at rest persist in croup after the administration of oral prednisolone?
    Robyn Parker
    Department of Emergency Medicine, Northern Hospital, Cardiff, UK
    Emerg Med Australas 16:135-8. 2004
    ..at rest (SAR) after the administration of oral prednisolone (1 mg/kg) to children admitted to hospital with croup from the ED...
  27. ncbi Frequency of anesthesia-related complications in children with Down syndrome under general anesthesia for noncardiac procedures
    Lawrence M Borland
    Department of Pediatric Anesthesiology, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Paediatr Anaesth 14:733-8. 2004
    ..Craniofacial and cardiac anomalies of Down syndrome (DS; trisomy 21) would seem to place these patients at higher risk of anesthesia-related complications (ARCs), but to date no comprehensive large-scale study has quantified this risk...
  28. ncbi [Croup in children--results of prospective, multicenter observation]
    Leszek Szenborn
    Klinika Chorób Zakaźnych Dzieci, Akademii Medycznej we Wrocławiu
    Przegl Lek 61:457-62. 2004
    b>Croup syndrome is an urgent and frequent reason for hospitalization of children.
  29. ncbi Viral croup in children
    Janelle Gardner
    School of Nursing, California State University, Chico, CA, USA
    Nursing 38:57-8. 2008
  30. ncbi Controlled delivery of high vs low humidity vs mist therapy for croup in emergency departments: a randomized controlled trial
    Dennis Scolnik
    Division of Pediatric Emergency Medicine, The Hospital for Sick Children, and University of Toronto, Toronto, Ontario
    JAMA 295:1274-80. 2006
    Children with croup are often treated with humidity even though this is not scientifically based, consumes time, and can be harmful...
  31. ncbi Dexamethasone reduces reintubation rate due to postextubation stridor in a high-risk paediatric population
    Ingrid M A Lukkassen
    Department of Paediatrics, St Antonius Hospital, Nieuwegein, The Netherlands
    Acta Paediatr 95:74-6. 2006
    ..To study the effect of dexamethasone on postextubation stridor (PS) incidence and reintubation rate due to PS in a high-risk paediatric intensive care population...
  32. ncbi Fit and seal characteristics of a new paediatric tracheal tube with high volume-low pressure polyurethane cuff
    A Dullenkopf
    Department of Anaesthesia, University Children's Hospital Zurich, Zurich, Switzerland
    Acta Anaesthesiol Scand 49:232-7. 2005
    ..Sealing pressure was assessed by auscultation. Post-extubation croup requiring therapy was noted. RESULTS: Five-hundred children were studied...
  33. ncbi Management of stridor in neonates and infants
    J Claes
    Department of Otorhinolaryngology, Head and Neck Surgery, Antwerp University Hospital, Belgium
    B-ENT . 2005
    ..Stridor may be congenital or acquired, acute, intermittent or chronic. Laryngotracheal inflammation (croup) is the most common cause of acute stridor...
  34. ncbi A prospective, randomized double-blind study in children comparing two doses of nebulized L-epinephrine in postintubation croup
    Aroonwan Preutthipan
    Departments of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University Bangkok, Thailand
    J Med Assoc Thai 88:508-12. 2005
    ..05 mL/kg versus 0.5 mL/kg in the treatment of postintubation croup in children...
  35. ncbi Managing children with croup in emergency departments
    Juliet Dykes
    Royal Hospital for Sick Children, Edinburgh
    Emerg Nurse 13:14-9. 2005
  36. ncbi Pulmonary arterial pressure in children with croup syndrome
    Bulent Oran
    Department of Pediatrics and Otorhinolaryngology, Meram Medical Faculty, Selcuk University, Konya, Turkey
    Am J Otolaryngol 27:150-3. 2006
    b>Croup syndrome or laryngotracheitis is one of the frequent causes of transient upper airway obstruction by laryngeal and tracheal blockage in infants and children...
  37. ncbi Epiglottitis and croup
    Steven E Sobol
    Department of Otolaryngology Head and Neck Surgery, Emory University School of Medicine, 1405 Clifton Road, Atlanta, GA 30322, USA
    Otolaryngol Clin North Am 41:551-66, ix. 2008
    Infections of the upper airways are a frequent cause of morbidity in children. Viral laryngotracheobronchitis (croup) is the most common cause of stridor in children and usually has a self-limited course with occasional relapses in early ..
  38. ncbi Croup
    Graham Worrall
    Family Medicine at Memorial University of Newfoundland in St John's
    Can Fam Physician 54:573-4. 2008
  39. ncbi Respiratory viruses in laryngeal croup of young children
    Heikki Rihkanen
    Department of Otorhinolaryngology, Head and Neck Surgery, Helsinki University Central Hospital, Helsinki, Finland
    J Pediatr 152:661-5. 2008
    To determine the viral cause of laryngeal croup by use of highly sensitive methods, and including recently recognized viruses in the analysis.
  40. ncbi Trends in pneumonia and empyema in Scottish children in the past 25 years
    C S D Roxburgh
    Department of Child Health, Royal Aberdeen Children s Hospital, Foresterhill, Aberdeen AB25 2ZG, UK
    Arch Dis Child 93:316-8. 2008
    ..The incidence of childhood empyema, a complication of pneumonia, is increasing, and the underlying mechanisms are not understood. Whether a rise in pneumonia incidence could account for the increase in empyema remains to be seen...
  41. ncbi Recurrent croup presentation, diagnosis, and management
    Kelvin Kwong
    Wayne State University School of Medicine, Detroit, MI 48201, USA
    Am J Otolaryngol 28:401-7. 2007
    The lack of clinical insight into recurrent croup often leads to underdiagnosis of an upper airway lesion, and subsequently, inadequate treatment...
  42. ncbi [Seroepidemiological surveillance of human parainfluenza viruses (HPIVs) types 2 and 3 in an infantile population selected in Havana City]
    Lídice Palerm Caraballo
    Instituto de Medicina Tropical Pedro Kouri, Ciudad de La Habana, Cuba
    Rev Cubana Med Trop 57:169-74. 2005
    ..9%). The circulation of human parainfluenza viruses was corroborated during all the months of the year and in all the analyzed age groups. It was observed an increase in the positivity percentages with age...
  43. ncbi Use of helium-oxygen mixtures in the treatment of croup: a systematic review
    C Vorwerk
    Emergency Department Academic Unit, Leicester Royal Infirmary, Leicester LE1 5WW, UK
    Emerg Med J 25:547-50. 2008
    To determine the effect of helium-oxygen inhalation on relieving symptoms and distress in children with croup as measured by the croup score, and to identify areas of uncertainty for future research.
  44. ncbi Tracheostomy in human immuno-deficiency virus infected children at the Red Cross War Memorial Children's Hospital, Cape Town, South Africa
    W K Mulwafu
    Department of Otolaryngology, Red Cross War Memorial Children s Hospital and School of Child and Adolescent Health, University of Cape Town, 7700 Cape Town, South Africa
    Int J Pediatr Otorhinolaryngol 71:1125-8. 2007
    ..The cause of upper airway obstruction was croup in 14 (93%) of these 15 children. Following tracheostomy all were treated with ART...
  45. ncbi Hospitalizations with primary versus secondary discharge diagnoses of asthma: implications for pediatric asthma surveillance
    David G Bundy
    Center for Health Care Quality, Cincinnati Children s Hospital Medical Center, Chapel Hill, North Carolina, USA
    J Pediatr 150:446-9, 449.e1. 2007
    ..Surveillance systems tracking the hospitalization burden of pediatric asthma should consider including selected hospitalizations with a secondary diagnosis of asthma...
  46. ncbi Paediatric airway emergencies in Northern Ireland, 1990-2003
    B Devlin
    Otolaryngology Department, Ulster Hospital, Belfast, Northern Ireland
    J Laryngol Otol 121:659-63. 2007
    ..The most common conditions are acute viral laryngotracheobronchitis (croup), acute epiglottitis and bacterial tracheitis...
  47. ncbi Clinical manifestations of human coronavirus NL63 infection in children in Taiwan
    Ping Sheng Wu
    Department of Pediatrics, Buddhist Tzu Chi General Hospital, Taipei Branch, Taipei, Taiwan
    Eur J Pediatr 167:75-80. 2008
    ..HCoV-NL63 was the most common pathogen (14.7%) in children with croup and was the cause of three cases of croup in October...
  48. ncbi Human Coronavirus-NL63 infections in Korean children, 2004-2006
    Tae Hee Han
    Department of Diagnostic Laboratory Medicine, Sanggyepaik Hospital, College of Medicine, Inje University, Seoul, Republic of Korea
    J Clin Virol 38:27-31. 2007
    ..Human coronavirus-NL63 (HCoV-NL63) has been isolated from children with respiratory tract infections and its prevalence in Korea has not been reported...
  49. ncbi Detection of human bocavirus in Canadian children in a 1-year study
    Nathalie Bastien
    National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington St, Winnipeg, Manitoba R3E 3R2, Canada
    J Clin Microbiol 45:610-3. 2007
    ..The spectrum of illness included upper respiratory infection, croup, bronchiolitis, and pneumonia with a prominence of cough and fever.
  50. ncbi [Evaluation of chosen parameters of acute-phase reaction in children during pseudocroup according to their age]
    Beata Pucher
    Klinika Otolaryngologii Dzieciecej Katedry Otolaryngologii AM w Poznaniu
    Otolaryngol Pol 60:743-6. 2006
    ..Analysis of glycosylation profile revealed acute inflammatory process during episode of pseudocroup in the oldest children (over 5 years old) and chronic inflammation in group of the youngest children...
  51. ncbi Changing epidemiology of life-threatening upper airway infections: the reemergence of bacterial tracheitis
    Amelia Hopkins
    Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA
    Pediatrics 118:1418-21. 2006
    ..We report our experience over 9 years with viral croup, epiglottitis, and bacterial tracheitis...
  52. ncbi Use of heliox in children
    Timothy R Myers
    Asthma Center, Cleveland, OH 44106, USA
    Respir Care 51:619-31. 2006
    ..This article reviews the rationale and methods for heliox treatment of children with asthma, airway obstruction, bronchiolitis, and croup.
  53. ncbi Correlating the clinical course of recurrent croup with endoscopic findings: a retrospective observational study
    Michael Hoa
    Department of Otolaryngology Head and Neck Surgery, Wayne State University, Detroit, MI 48201, USA
    Ann Otol Rhinol Laryngol 117:464-9. 2008
    We sought to correlate endoscopic findings with the clinical course of recurrent croup.
  54. ncbi Intramuscular versus oral dexamethasone for the treatment of moderate-to-severe croup: a randomized, double-blind trial
    David Donaldson
    Department of Emergency Medicine, William Beaumont Hospital, Royal Oak, MI 48067, USA
    Acad Emerg Med 10:16-21. 2003
    Glucocorticoids are an effective treatment for croup, although the most beneficial route of administration remains unclear...
  55. ncbi [Acute epiglottitis or so-called pseudocroup? Dyspnea is always a true emergency]
    A Klemens
    HNO Klinik, Klinikum Starnberg GmbH
    MMW Fortschr Med 144:38-40. 2002
  56. ncbi [Acute dyspnea in childhood. Croup or foreign body--bronchiolitis or asthma?]
    M Griese
    Dr von Hauner sches Kinderspital, Munchen
    MMW Fortschr Med 145:40-3. 2003
    ..perinatal complications and infections are major causes, in infants bronchiolitis/obstructive bronchitis and croup, while in older children and adolescents acute asthmatic attacks and pneumonia predominate...
  57. ncbi Diagnosis of recurrent intermittent airway obstruction ("recurrent croup") in children
    T L Farmer
    Department of Otolaryngology-Head and Neck Surgery, Virginia Commonwealth University School of Medicine, and Children's Hospital, Richmond, USA
    Ann Otol Rhinol Laryngol 110:600-5. 2001
    ..can present with a constellation of signs and symptoms labeled by their primary care physician as "recurrent croup." Recurrent croup, however, is not a diagnosis and should alert the clinician to the potential for intrinsic ..
  58. ncbi Clinical courses of croup caused by influenza and parainfluenza viruses
    Ville Peltola
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    Pediatr Infect Dis J 21:76-8. 2002
    Influenza viruses have occasionally been associated with severe manifestations of croup, but no comparative studies of different viral etiologies are available...
  59. ncbi Pediatric pulmonary emergencies
    William S Krost
    Emergency Medicine Special Operations Institute, University of Cincinnati College of Medicine, USA
    Emerg Med Serv 33:71-7; quiz 105. 2004
  60. ncbi Viral croup
    Doug Knutson
    Department of Family Medicine, Ohio State University College of Medicine and Public Health, Columbus, Ohio 43201, USA
    Am Fam Physician 69:535-40. 2004
    Viral croup is the most common form of airway obstruction in children six months to six years of age. The frightening nature of croup often prompts parents and caregivers to seek physician consultation...
  61. ncbi [Rare acute disease pictures of the upper respiratory tract in children]
    A E Oestreich
    Children s Hospital Medical Center, 3333 Burnet AV, Cincinnati, OH 45229 3039, USA
    Radiologe 42:217-21. 2002
    The radiologist should recognize dangerous uncommon conditions such as epiglottitis and membranous croup by their pattern on conventional images...
  62. ncbi [Heliox in pediatrics]
    Pascal Stucki
    CHUV, BHO5, Rue du Bugnon 46 1011 Lausanne
    Rev Med Suisse Romande 122:637-9. 2002
    ..Its usefulness in the child is established in croup or in post-extubation stridor...
  63. ncbi Upper airway obstruction
    P B Baines
    Paediatric Intensive Care Unit, Royal Liverpool Children's Hospital, Liverpool L12 2AP
    Hosp Med 65:108-11. 2004
  64. ncbi Relation of two different subtypes of croup before age three to wheezing, atopy, and pulmonary function during childhood: a prospective study
    J A Castro-Rodriguez
    Respiratory Sciences Center, University of Arizona, College of Medicine, Tucson, Arizona, USA
    Pediatrics 107:512-8. 2001
    Some retrospective evidence suggests that children with a history of croup may be at increased risk of subsequently developing asthma, atopy, and diminished pulmonary function...
  65. ncbi Clinical presentation as a guide to the identification of GERD in children
    M M Carr
    Department of Pediatric Otolaryngology, Children s Hospital of Buffalo, 219 Bryant St, Buffalo, NY 14222, USA
    Int J Pediatr Otorhinolaryngol 54:27-32. 2000
    ..to determine if there is a correlation between common otolaryngologic symptoms and presence of gastroesophageal reflux disease (GERD) in children...
  66. ncbi Respiratory syncytial virus and human rhinoviruses are the major causes of severe lower respiratory tract infections in Kuwait
    M Khadadah
    Department of Medicine, Faculty of Medicine, Kuwait University, Kuwait
    J Med Virol 82:1462-7. 2010
    ..One hundred fifty-five (53.8%) presented with bronchiolitis, 100 (43.7%) with pneumonia, and 33 (11.5%) with croup. One hundred six (36.8%) and 99 (34...
  67. ncbi Suppression of pulmonary host defenses and enhanced susceptibility to respiratory bacterial infection in mice following inhalation exposure to trichloroethylene and chloroform
    MaryJane K Selgrade
    Office of Research and Development, National Health and Environmental Effects Research Laboratory, U S EPA, Research Triangle Park, NC, USA
    J Immunotoxicol 7:350-6. 2010
    ..episodes of increased air pollution with increased incidence of respiratory disease, including pneumonia, croup, and bronchitis. Trichloroethylene (TCE) and chloroform are among 33 hazardous air pollutants identified by the U...
  68. ncbi The pediatric hybrid observation unit: an analysis of 6477 consecutive patient encounters
    Michelle Zebrack
    Division of Pediatric Emergency Medicine, Primary Children s Medical Center, 100 N Medical Dr, Salt Lake City, UT 84113, USA
    Pediatrics 115:e535-42. 2005
    ....
  69. ncbi Pulmonary diseases and corticosteroids
    G R Sethi
    Department of Pediatrics Maulana Azad Medical College, New Delhi, India
    Indian J Pediatr 75:1045-56. 2008
    ..Corticosteroids are used in many pulmonary conditions. Corticosteroids have a proven beneficial role in asthma, croup (Laryngotracheobronchitis), decreasing the risk and severity of respiratory distress syndrome (RDS), allergic ..
  70. ncbi Respiratory syncytial virus: the virus, the disease and the immune response
    Pearay L Ogra
    Department of Pediatrics, State University of New York at Buffalo, Children s Hospital of Buffalo, NY 14222, USA
    Paediatr Respir Rev 5:S119-26. 2004
    ..ranges from mild upper tract illness, infection in middle ear which progresses to acute otitis media, croup, to apnoea in premature infants, pneumonia and bronchiolitis...
  71. ncbi Membranous laryngitis in a child
    Michael Somenek
    Rush University Medical Center, 1653 W Congress Parkway, Department of Otolaryngology, Chicago, IL 60612, USA
    Int J Pediatr Otorhinolaryngol 74:704-6. 2010
    The most common etiologies for acute infectious airway obstruction include epiglottitis, croup, and bacterial tracheitis. We present a unique cause of upper airway obstruction in a child not previously described...
  72. ncbi [Evaluation of Seeplex RV detection kit for detecting rhinovirus, human metapneumovirus, and coronavirus]
    Heungsup Sung
    Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea
    Korean J Lab Med 28:109-17. 2008
    ..The objective of this study was to evaluate a multiplex reverse transcriptase-PCR method using Seeplex RV Detection kit (Seegene, Korea) for the detection of rhinovirus, coronavirus, and human metapneumovirus (hMPV)...
  73. ncbi Early respiratory infections, asthma, and allergy: 10-year follow-up of the Oslo Birth Cohort
    Per Nafstad
    Department of General Practice and Community Medicine, Medical Faculty, University of Oslo, PB 1130 Blindern, 0316 Oslo, Norway
    Pediatrics 116:e255-62. 2005
    ..We also considered birth order and attendance at a child care center as proxy measures of increased exposure to infections early in life...
  74. ncbi Assessing disease burden of respiratory disorders in Hong Kong children with hospital discharge data and linked laboratory data
    Edmund A S Nelson
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Hong Kong Med J 13:114-21. 2007
    ..To describe the pattern of respiratory disorders in the Hong Kong paediatric population admitted to government hospitals, and to assess the reliability of the diagnoses by linkage with laboratory data...
  75. ncbi Risk factors associated with severe viral croup in hospitalised Malaysian children
    P W K Chan
    Department of Paediatrics, University Malaya Medical Centre, Kuala Lumpur, Malaysia
    Singapore Med J 43:124-7. 2002
    To determine the risk factors associated with severe viral croup in hospitalised Malaysian children.
  76. ncbi Transcutaneous carbon dioxide monitoring in infants and children
    Joseph D Tobias
    Division of Pediatric Anesthesiology, Departments of Anesthesiology and Pediatrics, University of Missouri, 3W 27G HSC, One Hospital Drive, Columbia, MO 65212, USA
    Paediatr Anaesth 19:434-44. 2009
    ..To review the technology required for and the applications of transcutaneous carbon dioxide (TC-CO2) monitoring in infants and children...
  77. ncbi Influence of chromium tripicolinate on growth and glucose metabolism in yearling horses
    E A Ott
    Animal Science Department, University of Florida, Gainesville 32611 0910, USA
    J Anim Sci 77:3022-30. 1999
    ..weighed, measured for withers and hip height, heart girth, and body length and underwent ultrasound evaluation for croup fat thickness. The concentrate was fed for ad libitum consumption for two, 1.5-hr feeding periods daily...
  78. ncbi Rapid diagnosis of Mycoplasma pneumoniae infection in children by polymerase chain reaction
    Fang Ching Liu
    Department of Pediatrics, Jen Ai Hospital, Taichung, Taiwan
    J Microbiol Immunol Infect 40:507-12. 2007
    ..A rapid test would be useful to define the etiology and initiate appropriate management. We studied the usefulness of polymerase chain reaction (PCR) analysis for diagnosis in this setting...
  79. ncbi Development of toxicity criteria for petroleum hydrocarbon fractions in the Petroleum Hydrocarbon Criteria Working Group approach for risk-based management of total petroleum hydrocarbons in soil
    L E Twerdok
    Health and Environmental Sciences Department, American Petroleum Institute, NW, Washington, DC 20005, USA
    Drug Chem Toxicol 22:275-91. 1999
    The Total Petroleum Hydrocarbon Criteria Working Croup (TPHCWG) was formed in 1993 based on the observation that widely different clean-up requirements were being used by states at sites that were contaminated with hydrocarbon materials ..
  80. ncbi Acute upper respiratory infections in Western Australian emergency departments, 2000-2003
    Sharyn L Ingarfield
    Emergency Medicine, University of Western Australia, R Block, Level 2, QEII Medical Centre, Nedlands, Perth, WA 6009, Australia
    Aust Health Rev 32:691-9. 2008
    ..To describe the epidemiological and other characteristics of emergency department (ED) presentations diagnosed with acute upper respiratory infection (URI)...
  81. ncbi Day care attendance in the first year of life and illnesses of the upper and lower respiratory tract in children with a familial history of atopy
    J C Celedon
    Channing Laboratory and Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Pediatrics 104:495-500. 1999
    ..To examine the relationship between day care attendance and illnesses of the upper and lower respiratory tract in the first year of life...
  82. ncbi Recurrent respiratory papillomatosis: a review
    Craig S Derkay
    Department of Otolaryngology Head and Neck Surgery, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    Laryngoscope 118:1236-47. 2008
    ..Differential diagnoses include asthma, croup, allergies, vocal nodules, or bronchitis. Reports estimate the incidence of RRP in the United States at 4...
  83. ncbi A comparison of parent-reported wheezing or shortness of breath among infants as assessed by questionnaire and physician-interview: The Generation R study
    Ashna D Mohangoo
    The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, The Netherlands
    Pediatr Pulmonol 45:500-7. 2010
    ..The aim of this study was to compare parent-reported wheezing or shortness of breath among infants as assessed by questionnaire and physician-interview...
  84. ncbi Sex differences in the incidence and severity of respiratory tract infections
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos Street, 151 23 Marousi, Greece
    Respir Med 101:1845-63. 2007
    ..On the other hand, males are more commonly affected with otitis media, croup, and most important, lower RTIs...
  85. ncbi Epidemiology and clinical presentations of human coronavirus NL63 infections in hong kong children
    Ting Fan Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong
    J Clin Microbiol 47:3486-92. 2009
    ..HCoV-NL63-infected patients were younger and more likely to have croup, febrile convulsions, and acute gastroenteritis...
  86. ncbi Acute dyspnea in the office
    Roger J Zoorob
    Department of Family Medicine, Louisiana State University School of Medicine Health Sciences Center, Kenner, Louisiana 70065, USA
    Am Fam Physician 68:1803-10. 2003
    ..Differential diagnoses in children include bronchiolitis, croup, epiglottitis, and foreign body aspiration...
  87. ncbi Safety and immunogenicity of intranasal murine parainfluenza virus type 1 (Sendai virus) in healthy human adults
    Karen S Slobod
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Vaccine 22:3182-6. 2004
    Human parainfluenza virus-type 1 (hPIV-1) is the most common cause of pediatric laryngotracheobronchitis (croup) and results in close to 30,000 US hospitalizations each year. No effective vaccine is available...
  88. ncbi National disease burden of respiratory viruses detected in children by polymerase chain reaction
    Kelly J Henrickson
    Department of Pediatrics, Medical College of Wisconsin and Children s Hospital of Wisconsin, Milwaukee, 53226, USA
    Pediatr Infect Dis J 23:S11-8. 2004
    ..The epidemiology of community-acquired respiratory viruses at the Children's Hospital of Wisconsin between 1996 and 1998 was examined with molecular [multiplex (M) PCR] and standard virologic methods...
  89. ncbi Benchmarks for the emergency department care of children with asthma, bronchiolitis, and croup
    Jane F Knapp
    Children s Mercy Hospitals and Clinics, The University of Missouri Kansas City School of Medicine, Kansas City, MO, USA
    Pediatr Emerg Care 26:364-9. 2010
    ..children's hospital emergency departments (EDs) in the care of children with asthma, bronchiolitis, and croup (ABC) using 5 clinical quality indicators and (2) to construct achievable benchmarks for 7 clinical quality ..
  90. ncbi Gaps in enrollment from a Medicaid managed care program: effects on emergency department visits and hospitalizations for children with asthma
    William O Cooper
    Division of General Pediatrics, Vanderbilt Children s Hospital, Nashville, Tennessee 37232 8555, USA
    Med Care 43:718-25. 2005
    ..For high-risk children with asthma enrolled in Medicaid, loss of Medicaid coverage is a potential threat to access to quality asthma care...
  91. ncbi Pediatric otolaryngologic manifestations of gastroesophageal reflux disease
    Mark A Gilger
    Baylor College of Medicine, Texas Children s Hospital, Room 1010, 6621 Fannin, Houston, TX 77030 2399, USA
    Curr Gastroenterol Rep 5:247-52. 2003
    ..attributed to GERD, including hoarseness, laryngitis, chronic rhinitis, sinusitis, globus pharyngeus, recurrent croup, laryngomalacia, stridor, subglottic stenosis, otalgia, vocal cord granulomas, and oropharyngeal dysphagia...
  92. ncbi Impact of respiratory virus infections on persons with chronic underlying conditions
    W P Glezen
    Department of Microbiology and Immunology, Baylor College of Medicine, Houston, Tex 77030, USA
    JAMA 283:499-505. 2000
    ..Development of new approaches for prevention of acute respiratory tract conditions requires studies of the etiologies of infections and quantification of the risk of hospitalization for vulnerable patients...
  93. ncbi Interactive effect of family history and environmental factors on respiratory tract-related morbidity in infancy
    Sandra Kuiper
    Department of General Practice, Care and Public Health Research Institute, University of Maastricht, Maastricht, The Netherlands
    J Allergy Clin Immunol 120:388-95. 2007
    ..Family and environmental factors affect the development of respiratory morbidity. How these factors interact is unclear...
  94. ncbi Cost-effectiveness of palivizumab in New Zealand
    A M Vogel
    Department of Paediatrics, University of Auckland, New Zealand
    J Paediatr Child Health 38:352-7. 2002
    ..To establish the preterm infant hospitalization risks from respiratory syncytial virus (RSV) in New Zealand and the net cost per hospitalization averted by palivizumab...
  95. ncbi The effectiveness of local corticosteroids therapy in the management of mild to moderate viral croup
    M Eboriadou
    Second Pediatric Department, School of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece
    Minerva Pediatr 62:23-8. 2010
    The purpose of this study was to determine whether local anti-inflammatory therapy with inhaled beclomethasone dipropionate is effective in the outpatient management of acute viral croup.
  96. ncbi [Efficacy of heliox therapy in respiratory insufficiency in infants and children]
    C Iglesias Fernández
    Seccion de Cuidados Intensivos Pediatricos, Hospital General Universitario Gregorio Maranon, Madrid, Espana
    An Pediatr (Barc) 66:240-7. 2007
    ..To analyze response to heliox therapy in critically ill infants and children with upper and/or lower airway respiratory insufficiency...
  97. ncbi The C proteins of human parainfluenza virus type 1 (HPIV1) control the transcription of a broad array of cellular genes that would otherwise respond to HPIV1 infection
    Jim B Boonyaratanakornkit
    Laboratory of Infectious Diseases, Respiratory Viruses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 8007, USA
    J Virol 83:1892-910. 2009
    ..virus type 1 (HPIV1) is an important respiratory pathogen in children and the most common cause of viral croup. We performed a microarray-based analysis of gene expression kinetics to examine how wild-type (wt) HPIV1 ..
  98. ncbi Relevance of human metapneumovirus in exacerbations of COPD
    G Rohde
    Department of Internal Medicine III, Pneumology, Allergology and Sleep Medicine, University Hospital Bergmannsheil, D 44789 Bochum, Germany
    Respir Res 6:150. 2005
    Human metapneumovirus (hMPV) is a recently discovered respiratory virus associated with bronchiolitis, pneumonia, croup and exacerbations of asthma...
  99. ncbi Factors associated with asthma in school children
    M A Moussa
    Department of Community Medicine and Behavioral Sciences, Faculty of Medicine, Kuwait University
    Eur J Epidemiol 12:583-8. 1996
    ..was used to obtain information about respiratory illnesses (pneumonia, bronchitis, bronchiolitis, sinusitis and croup); atopy (allergic rhinitis and atopic dermatitis) and familial allergic diseases (parental asthma and atopy)...
  100. ncbi The "air leak" test around the endotracheal tube, as a predictor of postextubation stridor, is age dependent in children
    Maroun J Mhanna
    Department of Pediatrics, Division of Pediatric Critical Care, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
    Crit Care Med 30:2639-43. 2002
    ..Our objectives were to determine whether the airleak test predicts postextubation stridor in children and if age affects its sensitivity and specificity...
  101. ncbi Subglottic hemangioma
    T J O-Lee
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Nevada School of Medicine, Las Vegas, NV 89102, USA
    Otolaryngol Clin North Am 41:903-11, viii-ix. 2008
    ..It is common for subglottic hemangioma to be misdiagnosed as croup initially...

Research Grants62

  1. Mechanisms of viral proteases in coronavirus replication and pathogenesis
    Andrew D Mesecar; Fiscal Year: 2010
    ..are positive strand RNA viruses which cause a range of illness, from relatively mild respiratory disease (croup and common cold like symptoms due to HCoV- NL63, 229e or OC43) to severe acute respiratory syndrome (SARS) ..
  2. Glycoprotein interactions in paramyxovirus fusion
    Ronald M Iorio; Fiscal Year: 2010
    ..HPIV types 1-3 have long been recognized as causative agents of croup and as important respiratory pathogens, especially of infants and children and hPIVS is a major cause of pneumonia ..
  3. Glycoprotein interactions in paramyxovirus fusion
    RONALD IORIO; Fiscal Year: 2007
    ..HPIV types 1-3 have long been recognized as causative agents of croup and as important respiratory pathogens, especially of infants and children and hPIVS is a major cause of pneumonia ..
  4. A Simulator for Sound Production in Airways
    Ingo R Titze; Fiscal Year: 2010
    ..g. snoring, pediatric strider, croup, and several symptoms of influenza and the common cold)...
  5. A Simulator for Sound Production in Airways
    Ingo Titze; Fiscal Year: 2007
    ..g. snoring, pediatric strider, croup, and several symptoms of influenza and the common cold)...
  6. A Simulator for Sound Production in Airways
    Ingo Titze; Fiscal Year: 2009
    ..g. snoring, pediatric strider, croup, and several symptoms of influenza and the common cold)...
  7. HOST VIRUS INTERACTION AND GENE EXPRESSION
    Amiya Banerjee; Fiscal Year: 1993
    ..in different parts of the world indicate that these viruses are associated with approximately 40% of severe croup in children. HPIV3 is most pathogenic among the other HPIV types...
  8. MOLECULAR BASIS FOR PARAINFLUENZA 3 INFECTION
    Anne Moscona; Fiscal Year: 2002
    ..lower respiratory tract disease in children and causes several of the most significant childhood viral diseases (croup, bronchiolitis and pneumonia). The recognition of infections caused by HPF3 is increasing in the U.S...
  9. Pulsus Paradoxus Monitor
    Gregory Jay; Fiscal Year: 2005
    ..Pulsus paradoxus is present in asthma, croup, and pericardial tamponade and tension pneumothorax. It appears prior to hypoxia in all of these conditions...
  10. Developing Quality Measures to Assess Pediatric Inpatient Respiratory Care
    Rita Mangione Smith; Fiscal Year: 2010
    ..assessment of inpatient management for children treated for six respiratory conditions: asthma, bronchiolitis, croup, pneumonia, congenital lung malformations, and cystic fibrosis...
  11. Developing Quality Measures to Assess Pediatric Inpatient Respiratory Care
    Rita Mangione Smith; Fiscal Year: 2009
    ..assessment of inpatient management for children treated for six respiratory conditions: asthma, bronchiolitis, croup, pneumonia, congenital lung malformations, and cystic fibrosis...
  12. HOST VIRUS INTERACTION AND GENE EXPRESSION
    Amiya Banerjee; Fiscal Year: 2006
    ..epithelial cells of the respiratory tract of infants and children leading to acute bronchiolitis, pneumonia and croup. Effective vaccines or antivirals to combat HPIV3 infection are currently unavailable...
  13. Study of HPIV3 replication using reverse genetics
    Michael Hoffman; Fiscal Year: 2006
    ..in an important respiratory tract pathogen capable of causing diseases such as pneumonia, bronchiolitus and croup in infants, young children, elderly and immunocompromised individuals...
  14. Mechanisms of cardiovascular remodeling
    ANTHONY GERDES; Fiscal Year: 2006
    ..NIH-funded research programs and will add depth and additional expertise to the croup. We believe the end result will be an internationally recognized research program that makes substantial ..
  15. COLUMBIA UNIVERSITY SOUTHWEST ONCOLOGY GROUP PROGRAM
    Daniel Petrylak; Fiscal Year: 2003
    ..strategies for cancer at Columbia for eventual evaluation in larger clinical trials in the Southwest Oncology Croup. 2...
  16. Alphavirus-based Vaccine for Prevention of MPV Infection
    James Crowe; Fiscal Year: 2007
    ..The genetic features of the HIV-specific antibodies will be defined, and recombinant human monoclonal antibodies specified by these genes will be made for study of how broadly neutralizing HIV antibodies function. ..
  17. Genes, Home Allergens and Asthma in Puerto Rican Children
    JUAN CELEDON; Fiscal Year: 2009
    ..This application will contribute greatly to our understanding of asthma in general, and among Puerto Ricans in particular. ..
  18. Suicidality Associated with Antidepressants inTennCare Children and Adolescents
    William O Cooper; Fiscal Year: 2010
    ..Finally, understanding the risk of suicidality for periods off and on treatment will inform practitioners, patients, and families faced with treating an important condition. ..
  19. Genes, Home Allergens and Asthma in Puerto Rican Children
    JUAN CELEDON; Fiscal Year: 2007
    ..This application will contribute greatly to our understanding of asthma in general, and among Puerto Ricans in particular. ..
  20. ONTOGENY OF RSV-SPECIFIC B CELL RESPONSES IN HUMANS
    James Crowe; Fiscal Year: 2001
    ..The data from this work will direct decisions about the best vaccine strategy to use against RSV in neonates, and will delineate basic mechanisms of the ontogeny of B-cell repertoire diversity in humans. ..
  21. Multiplex PCR Detection of CDC 'A' Bioterrorism Agents
    Kelly Henrickson; Fiscal Year: 2005
    ..Specific Aim 4: To determine if this multiplex assay is equivalent to these "singleplex" assays in a clinical trial. ..
  22. The Genetic Epidemiology of Asthma in Costa Rica
    JUAN CELEDON; Fiscal Year: 2005
    ..In addition, it will create a bank of phenotypic and genotypic information that will facilitate further hypothesis testing in a unique patient cohort. ..
  23. The Epidemiology of Barrett's Esophagus in Children
    Mark Gilger; Fiscal Year: 2005
    ....
  24. Novel methods for generation of human B cell hybridomas
    James Crowe; Fiscal Year: 2005
    ..abstract_text> ..
  25. Human T Cells Responses to RSV
    James Crowe; Fiscal Year: 2006
    ..abstract_text> ..
  26. Cell-Mediated Immune Responses to Vaccinia Viruses
    James Crowe; Fiscal Year: 2006
    ..We will examine many of these questions by taking advantage of new technology that allows for examination of T cell responses at the single cell level, and in an immunodominant epitope specific manner. ..
  27. Alphavirus-based Vaccine for Prevention of MPV Infection
    James Crowe; Fiscal Year: 2007
    ..The consortium submitting this application brings together an experienced investigator group with expertise in pneumovirus and alphavirus virology, immunology, and vaccine development. ..
  28. Human Antibody Responses to Rotavirus
    James Crowe; Fiscal Year: 2007
    ..This work will demonstrate that infant B cell repertoires used to make specific antiviral responses, in contrast to much previous speculation, are much closer in character to adult repertoires than fetal repertoires. ..
  29. HUMAN MONOCLONAL ANTIBODIES THAT NEUTRALIZE VACCINIA
    James Crowe; Fiscal Year: 2002
    ..In summary, this work will yield a safe and effective immunotherapeutic strategy for treatment of vaccinia complications. ..