extrinsic allergic alveolitis

Summary

Summary: Conditions in which inhalation of organic dusts results in hypersensitivity reactions at the alveolar level, associated with the production of precipitins.

Top Publications

  1. ncbi Metal working fluid-associated hypersensitivity pneumonitis: an outbreak investigation and case-control study
    J Fox
    Centers for Disease Control and Prevention, Division of Field Epidemiology, Atlanta, GA, USA
    Am J Ind Med 35:58-67. 1999
  2. ncbi Hypersensitivity pneumonitis: current concepts and future questions
    A M Patel
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Allergy Clin Immunol 108:661-70. 2001
  3. pmc Gene expression profiles distinguish idiopathic pulmonary fibrosis from hypersensitivity pneumonitis
    Moises Selman
    Neurocrine Biosciences, 12790 El Camino Real, San Diego, CA 92130, USA
    Am J Respir Crit Care Med 173:188-98. 2006
  4. ncbi Extrinsic allergic alveolitis caused by misting fountains
    Dirk Koschel
    Zusamklinik der LVA Schwaben, Pneumology, Allergy and Sleep Medicine, Paracelsusstr 3, 86441 Zusmarshausen, Germany
    Respir Med 99:943-7. 2005
  5. ncbi Clinical diagnosis of hypersensitivity pneumonitis
    Yves Lacasse
    Centre de Pneumologie, Hopital Laval, Universite Laval, Ste Foy, Quebec, Canada
    Am J Respir Crit Care Med 168:952-8. 2003
  6. pmc Extrinsic allergic alveolitis (hypersensitivity pneumonitis) caused by Sphingobacterium spiritivorum from the water reservoir of a steam iron
    Peter Kampfer
    Institut fur Angewandte Mikrobiologie, Justus Liebig Universitat Giessen, Germany
    J Clin Microbiol 43:4908-10. 2005
  7. ncbi Cockade-like structures in alveolar macrophages in extrinsic allergic alveolitis
    Esra Uzaslan
    Department of Pneumology and Allergy, Ruhrlandklinik, Essen, Germany
    Respiration 72:46-51. 2005
  8. ncbi CCL18/DC-CK-1/PARC up-regulation in hypersensitivity pneumonitis
    A Pardo
    Facultad de Ciencias,
    J Leukoc Biol 70:610-6. 2001
  9. ncbi Extrinsic allergic alveolitis: inhibitory effects of pentoxifylline on cytokine production by alveolar macrophages
    Zhaohui Tong
    Department of Pneumology and Allergy, Ruhrlandklinik, Medical Faculty, University of Essen, Essen, Germany
    Ann Allergy Asthma Immunol 92:234-9. 2004
  10. ncbi Significance of precipitins and asymptomatic lymphocytic alveolitis: a 20-yr follow-up
    Y Cormier
    Unite de Recherche, Centre de Pneumologie, Dept de Radiologie, Institut Universitaire de Cardiologie et de Pneumologie, Hopital Laval, 2725 Chemin Ste Foy, Ste Foy, Quebec, Canada, G1V 4G5
    Eur Respir J 23:523-5. 2004

Research Grants

  1. The Role of Neutrophils in Hypersensitivity Pneumonitis
    Elizabeth Fitzpatrick; Fiscal Year: 2009
  2. The Role of Neutrophils in Hypersensitivity Pneumonitis
    ELIZABETH ANN FITZPATRICK; Fiscal Year: 2010
  3. The Role of Neutrophils in Hypersensitivity Pneumonitis
    Elizabeth Fitzpatrick; Fiscal Year: 2009
  4. The Role of Neutrophils in Hypersensitivity Pneumonitis
    Elizabeth Fitzpatrick; Fiscal Year: 2007
  5. Interleukin-4 effects on calcium in airway smooth muscle
    JOHN MADISON; Fiscal Year: 2005
  6. Novel Therapeutic Approaches in IPF
    Fernando Martinez; Fiscal Year: 2005
  7. Exposure Intervention in a Rural Pediatric Asthma Cohort
    Peter Thorne; Fiscal Year: 2004
  8. Interleukin-4 effects on calcium in airway smooth muscle
    JOHN MADISON; Fiscal Year: 2004
  9. Strategies to Prevent COPD Exacerbation
    Fernando Martinez; Fiscal Year: 2004
  10. Exposure Intervention in a Rural Pediatric Asthma Cohort
    Peter Thorne; Fiscal Year: 2003

Detail Information

Publications164 found, 100 shown here

  1. ncbi Metal working fluid-associated hypersensitivity pneumonitis: an outbreak investigation and case-control study
    J Fox
    Centers for Disease Control and Prevention, Division of Field Epidemiology, Atlanta, GA, USA
    Am J Ind Med 35:58-67. 1999
    ..Reactivity to used but not unused MWF suggests a biocontaminant, probably bacteria or fungi, is the causative antigen in the development of HP in this setting...
  2. ncbi Hypersensitivity pneumonitis: current concepts and future questions
    A M Patel
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Allergy Clin Immunol 108:661-70. 2001
    Hypersensitivity pneumonitis (extrinsic allergic alveolitis) caused by inhaled allergens can progress to disabling or even fatal end-stage lung disease. The only truly effective treatment is early recognition and control of exposure...
  3. pmc Gene expression profiles distinguish idiopathic pulmonary fibrosis from hypersensitivity pneumonitis
    Moises Selman
    Neurocrine Biosciences, 12790 El Camino Real, San Diego, CA 92130, USA
    Am J Respir Crit Care Med 173:188-98. 2006
    ..Many of the interstitial lung diseases represent a diagnostic and therapeutic challenge because their clinical and even histologic features are often nonspecific. Likewise, the transcriptional signatures of most of them are unknown...
  4. ncbi Extrinsic allergic alveolitis caused by misting fountains
    Dirk Koschel
    Zusamklinik der LVA Schwaben, Pneumology, Allergy and Sleep Medicine, Paracelsusstr 3, 86441 Zusmarshausen, Germany
    Respir Med 99:943-7. 2005
    ..A diagnosis of extrinsic allergic alveolitis (EAA) or toxic alveolitis was made on the basis of the history and the clinical, radiological, ..
  5. ncbi Clinical diagnosis of hypersensitivity pneumonitis
    Yves Lacasse
    Centre de Pneumologie, Hopital Laval, Universite Laval, Ste Foy, Quebec, Canada
    Am J Respir Crit Care Med 168:952-8. 2003
    ..The rule retained its accuracy when validated in a separate cohort of 261 patients. The diagnosis of HP can often be made or rejected with confidence, especially in areas of high or low prevalence, respectively, without BAL or biopsy...
  6. pmc Extrinsic allergic alveolitis (hypersensitivity pneumonitis) caused by Sphingobacterium spiritivorum from the water reservoir of a steam iron
    Peter Kampfer
    Institut fur Angewandte Mikrobiologie, Justus Liebig Universitat Giessen, Germany
    J Clin Microbiol 43:4908-10. 2005
    A case of extrinsic allergic alveolitis (EAA) caused by Sphingobacterium spiritivorum is described. The symptoms were associated with the use of a steam iron. The water reservoir was heavily contaminated with S...
  7. ncbi Cockade-like structures in alveolar macrophages in extrinsic allergic alveolitis
    Esra Uzaslan
    Department of Pneumology and Allergy, Ruhrlandklinik, Essen, Germany
    Respiration 72:46-51. 2005
    In immunocytochemical preparations of bronchoalveolar lavage (BAL) cells from patients with extrinsic allergic alveolitis (EAA), we observed the presence of alveolar macrophages with cockade-like structures in their cytoplasm (cockade+ ..
  8. ncbi CCL18/DC-CK-1/PARC up-regulation in hypersensitivity pneumonitis
    A Pardo
    Facultad de Ciencias,
    J Leukoc Biol 70:610-6. 2001
    ..High levels of CCL18 were detected in the subacute rather than the chronic phase of HP. These findings suggest a role for CCL18 in the pathogenesis of HP...
  9. ncbi Extrinsic allergic alveolitis: inhibitory effects of pentoxifylline on cytokine production by alveolar macrophages
    Zhaohui Tong
    Department of Pneumology and Allergy, Ruhrlandklinik, Medical Faculty, University of Essen, Essen, Germany
    Ann Allergy Asthma Immunol 92:234-9. 2004
    ..b>Extrinsic allergic alveolitis (EAA) is a granulomatous disease that is driven by T-cell and alveolar macrophage (AM)-derived ..
  10. ncbi Significance of precipitins and asymptomatic lymphocytic alveolitis: a 20-yr follow-up
    Y Cormier
    Unite de Recherche, Centre de Pneumologie, Dept de Radiologie, Institut Universitaire de Cardiologie et de Pneumologie, Hopital Laval, 2725 Chemin Ste Foy, Ste Foy, Quebec, Canada, G1V 4G5
    Eur Respir J 23:523-5. 2004
    ..Serum precipitins and asymptomatic lymphocytic alveolitis in an asymptomatic, exposed dairy farmer have no clinically meaningful long-term consequences...
  11. ncbi Needs and opportunities for research in hypersensitivity pneumonitis
    Jordan N Fink
    DLD NHLBI, Two Rockledge Center, 6701 Rockledge Drive, Bethesda, MD 20892 7952, USA
    Am J Respir Crit Care Med 171:792-8. 2005
    ....
  12. ncbi Chemokine production during hypersensitivity pneumonitis
    Stephanie Nance
    University of Tennessee Health Science Center, Department of Molecular Sciences, Memphis 38163, USA
    Eur J Immunol 34:677-85. 2004
    ..These results suggest that IFN-gamma mediates the recruitment of CXCR3+/CD4+ T cells into the lung via production of the chemokines IP-10, Mig, and I-TAC, resulting in granuloma formation...
  13. ncbi Hot tub lung: presenting features and clinical course of 21 patients
    Viktor Hanak
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Respir Med 100:610-5. 2006
    ..Hot tub lung is an emerging lung disorder associated with exposure to Mycobacterium avium complex organisms contaminating hot tub water...
  14. ncbi Production of soluble tumor necrosis factor receptors and tumor necrosis factor-alpha by alveolar macrophages in sarcoidosis and extrinsic allergic alveolitis
    Huaping Dai
    Department of Penumology and Allergy, Ruhrlandklinik, Medical Faculty, University of Essen, Essen, Germany
    Chest 127:251-6. 2005
    ..tumor necrosis factor (TNF)-alpha plays a pivotal role in the pathogenesis of sarcoidosis and extrinsic allergic alveolitis (EAA)...
  15. pmc Mycobacterium sp. as a possible cause of hypersensitivity pneumonitis in machine workers
    B G Shelton
    PathCon Laboratories, Norcross, Georgia 30092, USA
    Emerg Infect Dis 5:270-3. 1999
    ..Retrospective review of samples submitted to our laboratory showed an association between presence of mycobacteria and HP...
  16. ncbi Diffuse pulmonary disease caused by nontuberculous mycobacteria in immunocompetent people (hot tub lung)
    A Khoor
    Department of Pathology, Mayo Clinic, Jacksonville, FL, USA
    Am J Clin Pathol 115:755-62. 2001
    ..These findings suggest that disease due to NTM may manifest as diffuse infiltrates in immunocompetent adults and that hot tub use may be an important risk factor for this disease pattern...
  17. pmc Mycobacterial aerosols and respiratory disease
    Joseph O Falkinham
    Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA
    Emerg Infect Dis 9:763-7. 2003
    ..Disinfection may select for the predominance and growth of mycobacteria. Therefore, mycobacteria may be responsible, in part, for many outbreaks of hypersensitivity pneumonitis and other respiratory problems in the workplace and home...
  18. pmc Metalworking fluid with mycobacteria and endotoxin induces hypersensitivity pneumonitis in mice
    Peter S Thorne
    The University of Iowa, College of Public Health, 100 Oakdale Campus, IREH Iowa City, IA 52242 5000, USA
    Am J Respir Crit Care Med 173:759-68. 2006
    ..Other constituents of in-use metalworking fluids (MWFs) may also contribute to the development of lung disease. We investigated the potential for Mycobacterium immunogenum (MI) in MWFs to induce HP...
  19. ncbi Extrinsic allergic alveolitis
    Tengku Ismail
    Faculty of Medicine, Universiti Teknologi MARA, Shah Alam, Malaysia, and North Glasgow University Hospitals NHS Trust, UK
    Respirology 11:262-8. 2006
    b>Extrinsic allergic alveolitis (also known as hypersensitivity pneumonitis) is caused by repeated inhalation of mainly organic antigens by sensitized subjects...
  20. ncbi Case records of the Massachusetts General Hospital. Case 9-2005. A 67-year-old man with acute respiratory failure
    David M Systrom
    Department of Pulmonary and Critical Care, Massachusetts General Hospital, USA
    N Engl J Med 352:1238-46. 2005
  21. ncbi Mycobacterium immunogenum causes hypersensitivity pneumonitis-like pathology in mice
    Terry Gordon
    Institute of Environmental Medicine, New York University, School of Medicine, Tuxedo, New York, USA
    Inhal Toxicol 18:449-56. 2006
    ..immunogenum is an unrecognized class of microorganisms capable of causing hypersensitivity pneumonitis and plays a role in the outbreaks of hypersensitivity pneumonitis in automotive plants...
  22. ncbi Hot-tub lung: hypersensitivity to Mycobacterium avium but not hypersensitivity pneumonitis
    Ritesh Agarwal
    Respir Med 100:1478. 2006
  23. ncbi Hypersensitivity pneumonitis associated with Mycobacterium avium complex and hot tub use
    Otis B Rickman
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 77:1233-7. 2002
    ..Hypersensitivity to MAC, rather than an infection, is the likely underlying mechanism in these 2 cases of hot tub lung...
  24. ncbi [A case of hypersensitivity pneumonitis caused by inhalation of Mycobacterium avium from a home bath with a circulating water system]
    Hirotsugu Kenmotsu
    Department of Respiratory Medicine, Shizuoka General Hospital
    Nihon Kokyuki Gakkai Zasshi 43:689-92. 2005
    ..We believe the case is hypersensitivity pneumonitis to MAC in an immunocompetent patient, simulating hot tub lung. Hypersensitivity pneumonitis caused by MAC is rare in Japan...
  25. ncbi Hypersensitivity pneumonitis reaction to Mycobacterium avium in household water
    Theodore K Marras
    Division of Respirology, Toronto Western Hospital, Edith Cavell 4 022, 399 Bathurst St, Toronto, ON, Canada M5T 2S8
    Chest 127:664-71. 2005
    ..Hypersensitivity pneumonitis has been described with exposure to aerosolized Mycobacterium avium complex (MAC) in indoor hot tubs (hot tub lung)...
  26. ncbi Characterization of functional, radiologic and lung function recovery post-treatment of hot tub lung. A case report and review of the literature
    Nathaniel Marchetti
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Lung 182:271-7. 2004
    ..Prednisone therapy offered minimal further improvement while anti-MAC therapy provided no further improvement. These results are suggestive of a hypersensitivity pneumonitis rather than an infectious etiology...
  27. ncbi Hypersensitivity pneumonitis associated with hot tub use
    John M Travaline
    Arch Intern Med 163:2250; author reply 2250-1. 2003
  28. ncbi Mycobacterial contamination of metalworking fluids: involvement of a possible new taxon of rapidly growing mycobacteria
    J S Moore
    Department of Nuclear Engineering, Texas A and M University, College Station 77843 3133, USA
    AIHAJ 61:205-13. 2000
    ..The relationship of this mycobacterium to the cases of HP is unknown...
  29. ncbi Hot tub-related Mycobacterium avium intracellulare pneumonitis
    Amin Mery
    Immunology, Rheumatology, Allergy Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Allergy Asthma Proc 23:271-3. 2002
    ....
  30. ncbi [Case of pulmonary mycobacterium avium complex disease, showing hypersensitivity pneumonitis-like diffuse shadow]
    Rina Ohashi
    Department of Respiratory Disease, National Hospital Organization Tokyo National Hospital, Japan
    Kekkaku 81:19-23. 2006
    ..Although we did not examine the presence of Mycobacterium avium in the water of sauna bath, we suspected this case as Hot Tub Lung based on clinical features and the response to treatment...
  31. ncbi [Hypersensitivity pneumonitis: a technical note on precipitins]
    G Reboux
    Laboratoire de Parasitologie Mycologie, CHU de Besancon, Besancon, France
    Rev Mal Respir 20:140-3. 2003
  32. ncbi Metalworking fluid--the toxicity of a complex mixture
    Terry Gordon
    NYU School of Medicine, Tuxedo, New York 10987, USA
    J Toxicol Environ Health A 67:209-19. 2004
    ..This review discusses the methodologies used to examine the toxicity of the complex nature of modern metalworking fluids and the findings that point toward bacterial endotoxin as a major contributor to their adverse effects...
  33. ncbi The hypersensitivity pneumonitis diagnostic index: use of non-invasive testing to diagnose hypersensitivity pneumonitis in metalworkers
    Kenneth H Dangman
    Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut 06030, USA
    Am J Ind Med 42:150-62. 2002
    ..They had variable findings on clinical tests, which complicated diagnosis. An HP diagnostic index was developed to help reduce the uncertainties in case identification...
  34. ncbi [Prevalence of extrinsic allergic alveolitis in cattle breeders from the province of Reggio Emilia]
    F Ferri
    Distretto di Scandiano, Via Martiri della libertà 8, 42019 Scandiano, re
    Med Lav 94:380-90. 2003
    Several new cases of Extrinsic Allergic Alveolitis or Farmer's Lung (FL) in farm workers were reported to Occupational Health Services in the province of Reggio Emilia (Italy)...
  35. ncbi An outbreak of hypersensitivity pneumonitis at a metalworking plant: a longitudinal assessment of intervention effectiveness
    Anne Bracker
    University of Connecticut Health Center, Farmington, Connecticut, USA
    Appl Occup Environ Hyg 18:96-108. 2003
    ..1, df = 7, p <.0002). Measured oil mist air levels did not exceed the Occupational Safety and Health Administration's (OSHA's) permissible exposure limit (PEL), and in fact, did not exceed 0.5 mg/m(3)...
  36. ncbi Experimental hypersensitivity pneumonitis: role of MCP-1
    Mark Schuyler
    Department of Medicine, Albequerque Veterans Affairs Medical Center, University of New Mexico, 87108, USA
    J Lab Clin Med 142:187-95. 2003
    ..We conclude that interaction of MCP-1 with CCR2 is not necessary for the development of pulmonary inflammation in response to intratracheally administered S rectivirgula or cells able to adoptively transfer experimental HP...
  37. ncbi Hypersensitivity pneumonitis from Pezizia domiciliana. A case of El Niño lung
    R S Wright
    Department of Medicine, University of California, Los Angeles School of Medicine, Los Angeles, California, USA
    Am J Respir Crit Care Med 160:1758-61. 1999
    ..Open lung biopsy revealed extrinsic allergic alveolitis (hypersensitivity pneumonitis)...
  38. ncbi IgG antibodies typical for extrinsic allergic alveolitis--an inter-laboratory quality assessment
    W Aberer
    Division of Environmental Dermatology, Department of Dermatology, Auenbruggerplatz 8, A 8036 Graz, Austria
    Eur J Med Res 6:498-504. 2001
    Determination of specific IgG antibodies is important for the diagnosis of extrinsic allergic alveolitis (EAA)...
  39. pmc Hypersensitivity pneumonitis from ordinary residential exposures
    M J Apostolakos
    Pulmonary and Critical Care Division, Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Environ Health Perspect 109:979-81. 2001
    ..We propose that hypersensitivity pneumonitis may occur in North America, as it does in Japan, from domestic exposures alone...
  40. ncbi Machine operator's lung. A hypersensitivity pneumonitis disorder associated with exposure to metalworking fluid aerosols
    D I Bernstein
    University of Cincinnati College of Medicine, Department of Internal Medicine, OH, USA
    Chest 108:636-41. 1995
    ..Observed precipitin responses to a variety of microbial contaminants in metalworking fluid strongly suggest a causative role for microbial antigens in the induction and elicitation of this manifestation of hypersensitivity pneumonitis...
  41. ncbi High-resolution computed tomography in hypersensitivity pneumonitis - correlation with pulmonary function
    Dariusz Ziora
    Department of Pneumonology of the Silesian Medical Acatemy, Zabrze, Poland
    Ann Agric Environ Med 12:31-4. 2005
    ..Extent of pathological changes, i.e. nodularity, lines, honeycombing but not ground-glass estimated by HRCT and expressed as a score correlated significantly with lung function abnormalities...
  42. ncbi Uniportal VATS wedge pulmonary resections
    Gaetano Rocco
    The Price Thomas Thoracic Unit, Department of Cardiothoracic Surgery, Northern General Hospital, Sheffield, United Kingdom
    Ann Thorac Surg 77:726-8. 2004
    ..This initial experience shows that, for specific indications, uniportal video-assisted thoracic surgery for wedge pulmonary resections can be safe and effective...
  43. ncbi The role of bronchoalveolar lavage in diffuse parenchymal lung diseases
    Günseli Kilinç
    Department of Pulmonary Diseases, Cerrahpasa Medical Faculty, University of Istanbul, Turkey
    Curr Opin Pulm Med 11:417-21. 2005
    ..To evaluate the role of bronchoalveolar lavage in the diagnosis of diffuse parenchymal lung diseases and review the recent literature published within the past 12 months...
  44. ncbi Chronic hypersensitivity pneumonitis
    Andrew Churg
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Surg Pathol 30:201-8. 2006
    ..Despite the presence of extensive fibrosis, some patients responded to removal from exposure and steroid therapy...
  45. ncbi [Occupational hypersensitivity pneumonitis]
    I Thaon
    Service des Maladies Professionnelles, CHU de Besancon, France
    Rev Mal Respir 23:705-25. 2006
    ..The main purpose of this review is to report current concepts regarding aetiologies, epidemiology, diagnosis, treatment as well as legal aspects of HP...
  46. ncbi A woman with cough, fever, and micronodular infiltrates on chest radiograph
    Viranuj Sueblinvong
    University of Vermont Fletcher Allen Health Care, Burlington, VT 05401, USA
    South Med J 99:873-5. 2006
    ..We describe a patient with HP featuring well-formed granulomas on transbronchial biopsy specimens, a finding believed to be unique to MAC-related HP, also referred to as "hot tub lung"...
  47. ncbi Expression of the thioredoxin system in interstitial lung disease
    Leena Tiitto
    Department of Internal Medicine, University of Oulu and Oulu University Hospital, Oulu, Finland
    J Pathol 201:363-70. 2003
    ....
  48. ncbi [A familial case of summer-type hypersensitivity pneumonitis possibly associated with bird breeder's lung diagnosed by bronchoalveolar lavage fluid]
    Kiyoshi Makinodan
    Second Department of Interanl Medicine, Nara Medical University Center for Infectious Diseases
    Nihon Kokyuki Gakkai Zasshi 43:693-9. 2005
    ..Although a positive finding of returning-home provocation test was definitive in diagnosing summer-type hypersensitivity pneumonitis, he was also suspected of having bird fancier's lung...
  49. ncbi Increased surfactant protein-A levels in patients with newly diagnosed idiopathic pulmonary fibrosis
    David S Phelps
    Department of Pediatrics, Penn State College of Medicine, PO Box 850, Hershey, PA 17033, USA
    Chest 125:617-25. 2004
    ..To measure surfactant protein-A (SP-A) in the BAL of patients with idiopathic pulmonary fibrosis (IPF)...
  50. ncbi Expression of tumour necrosis factor receptors by bronchoalveolar cells in hypersensitivity pneumonitis
    B Chen
    Ruhrlandklinik, Tuschener Weg 40, 45239 Essen, Germany
    Eur Respir J 25:1039-43. 2005
    ..In conclusion, this study shows evidence of altered expression of tumour necrosis factor superfamily receptors in hypersensitivity pneumonitis...
  51. pmc Hypersensitivity pneumonitis associated with environmental mycobacteria
    William Beckett
    Pulmonary and Critical Care Division, Occupational Medicine Program and Finger Lakes Occupational Health Services, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Environ Health Perspect 113:767-70. 2005
    ..The employer, metalworking fluid supplier, union, and the National Institute for Occupational Safety and Health were notified of this sentinel health event. No further cases have been documented in this workplace...
  52. ncbi Therapeutic effects for hypersensitivity pneumonitis induced by Japanese mushroom (Bunashimeji)
    Kenji Tsushima
    First Department of Internal Medicine, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    Am J Ind Med 49:826-35. 2006
    ..An evaluation of protective measures was initiated using the outcomes of clinical, immunological, and radiological findings...
  53. ncbi [Mold fungi as disease agents. Sick people in sick houses?]
    P Stiefelhagen
    MMW Fortschr Med 146:4-6. 2004
  54. ncbi An outbreak of extrinsic alveolitis at a car engine plant
    Paul Dawkins
    Occupational Lung Disease Service, Birmingham Chest Clinic Heart of England NHS Trust, Great Charles Street, Birmingham B3 3HX, UK
    Occup Med (Lond) 56:559-65. 2006
    Twelve workers from a car engine-manufacturing plant presented with extrinsic allergic alveolitis (EAA), with heterogeneous clinical, radiological and pathological findings...
  55. ncbi Flow cytometric detection of cell-associated interleukin-8 in alveolar macrophages in vivo from patients with hypersensitivity pneumonitis and sarcoidosis
    S Fujishima
    Department of Emergency and Critical Care Medicine, School of Medicine, Keio University, Tokyo, Japan
    Scand J Clin Lab Invest 64:237-43. 2004
    ..However, the source of IL-8 may be different and AMs are the candidate source of IL-8 in HP, but not in SAR. The flow cytometric method may be useful in assessing cytokines production by AMs...
  56. ncbi Update in diffuse parenchymal lung diseases 2005
    Fernando J Martinez
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI 48109 0360, USA
    Am J Respir Crit Care Med 173:1066-71. 2006
  57. ncbi [Extrinsic allergic alveolitis]
    S Pabst
    Medizinische Poliklinik, Universitatsklinikum Bonn, Wilhelmstrasse 35 37, D 53111 Bonn E Mail
    Praxis (Bern 1994) 93:643-8. 2004
  58. ncbi Uniportal video-assisted thoracoscopic surgery wedge lung biopsy in the diagnosis of interstitial lung diseases
    Gaetano Rocco
    Price Thomas Thoracic Unit, Department of Cardiothoracic Surgery, Northern General Hospital, Sheffield Teaching Hospitals, Sheffield, United Kingdom
    J Thorac Cardiovasc Surg 129:947-8. 2005
  59. ncbi Interstitial lung diseases: characteristics at diagnosis and mortality risk assessment
    Michiel J Thomeer
    Department of Respiratory Medicine, Universitaire Ziekenhuizen Leuven, Afdeling Longziekten, Herestraat 49, Leuven B 3000, Belgium
    Respir Med 98:567-73. 2004
    ..A Cox regression analysis showed that type of ILD, FVC, age at diagnosis and % of macrophages in BALF predict outcome of patients affected by ILD...
  60. ncbi Pathology of hypersensitivity pneumonitis
    Tamiko Takemura
    Department of Pathology, Japanese Red Cross Medical Center, Japan
    Curr Opin Pulm Med 14:440-54. 2008
    ..This study reviews the previously reported information and provides new insights into the pathological features of chronic hypersensitivity pneumonitis...
  61. ncbi [Is it possible to diagnose interstitial pneumonia only with lung imaging?]
    J P Senac
    Imagerie Medicale, Hopital Arnaud de Villeneuve, Montpellier, France
    Rev Mal Respir 23:10S92-10S96. 2006
  62. ncbi Ground-glass opacity: interpretation of high resolution CT findings
    Giuseppe Battista
    Dipartimento Clinico di Scienze Radiologiche e Istocitopatologiche, Sezione Diagnostica per Immagini, Policlinico S Orsola Malpighi, Universita degli Studi, Bologna, Italy
    Radiol Med 106:425-42; quiz 443-4. 2003
    ..This distinction can be made by evaluating the vessel calibre and air trapping on expiratory scans...
  63. ncbi Microbial cell wall product contamination of bedding may induce pulmonary inflammation in rats
    B Ewaldsson
    AstraZeneca R and D, Laboratory Animal Resources, Molndal, Sweden
    Lab Anim 36:282-90. 2002
    ..The results suggest that further studies need to be undertaken to elucidate the role of microbial cell wall products in the development of inflammatory lung responses among research animals...
  64. ncbi Functional diversity of T-cell subpopulations in subacute and chronic hypersensitivity pneumonitis
    Lourdes Barrera
    Instituto Nacional de Enfermedades Respiratorias, Tlalpan 4502, CP 14080, Mexico DF, Mexico
    Am J Respir Crit Care Med 177:44-55. 2008
    ..Hypersensitivity pneumonitis (HP) exhibits a diverse outcome. Patients with acute/subacute HP usually improve, whereas patients with chronic disease often progress to fibrosis. However, the mechanisms underlying this difference are unknown...
  65. ncbi High-resolution CT in the evaluation of occupational and environmental disease
    Masanori Akira
    Department of Radiology, National Kinki Chuo Hospital for Chest Disease, Sakai City, Osaka, Japan
    Radiol Clin North Am 40:43-59. 2002
    ..HRCT is useful in achieving more accurate categorization of the parenchymal changes in each type of pneumoconiosis...
  66. ncbi Chronic hypersensitivity pneumonitis: differentiation from idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia by using thin-section CT
    C Isabela S Silva
    Department of Radiology, Vancouver General Hospital, University of British Columbia, 3350 950 W 10th Ave, Vancouver, BC, Canada V5Z 4E3
    Radiology 246:288-97. 2008
    ....
  67. ncbi Hypersensitivity pneumonitis induced by spores of Lyophyllum aggregatum
    K Tsushima
    First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Chest 120:1085-93. 2001
    ..However, the chest HRCT images showed the typical subacute phase of HP...
  68. ncbi [Hypersensitivity pneumonitis]
    V Spinu
    U M F Carol Davila Bucuresti, Catedra de Pneumologie
    Pneumologia 50:90-6. 2001
    ..Natural history, clinical findings, chest radiography, pulmonary function, immunological investigations, the use of the bronchoalveolar lavage, the prognostic and management of HP are discussed...
  69. ncbi Challenges in pulmonary fibrosis: 6--Problematic granulomatous lung disease
    J L Myers
    The University of Michigan Medical School, Ann Arbor, Michigan, USA
    Thorax 63:78-84. 2008
    ..This review focuses on the patterns of granulomatous inflammation that can cause diffuse lung disease, highlighting histopathological features helpful in differential diagnosis...
  70. ncbi Decreased expression of haem oxygenase-1 by alveolar macrophages in idiopathic pulmonary fibrosis
    Q Ye
    Dept of Pneumology and Allergology, Ruhrlandklinik, Medical Faculty, 45239 Essen, Germany
    Eur Respir J 31:1030-6. 2008
    ..This supports the hypothesis of an oxidant-antioxidant imbalance in the pathogenesis of idiopathic pulmonary fibrosis...
  71. pmc MyD88 is necessary for neutrophil recruitment in hypersensitivity pneumonitis
    Stephanie C Nance
    Deptartment of Molecular Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Leukoc Biol 83:1207-17. 2008
    ..rectivirgula exposure. The results from our studies suggest that one or more PRR(s) upstream of MyD88 are necessary for neutrophil recruitment following S. rectivirgula exposure...
  72. ncbi Human bronchoalveolar lavage fluid protein two-dimensional database: study of interstitial lung diseases
    R Wattiez
    Department of Biological Chemistry, University of Mons Hainaut, Belgium
    Electrophoresis 21:2703-12. 2000
    ..The significance of the modifications observed between the different lung pathologies is discussed with the aim of understanding the mechanistic bases of lung disease pathogenesis and finding new potential lung markers of disorders...
  73. doi High-resolution CT findings of parenchymal fibrosis correlate with prognosis in hypersensitivity pneumonitis
    Viktor Hanak
    Division of Pulmonary, Critical Care, and Sleep, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Chest 134:133-8. 2008
    ..Changes of pulmonary fibrosis detected on CT may also correlate with prognosis in patients with HP...
  74. ncbi [Chronic hypersensitivity pneumonitis induced by Shiitake mushroom cultivation: case report and review of literature]
    Naoko Kai
    Department of Infectious Diseases, Oita University Faculty of Medicine
    Nihon Kokyuki Gakkai Zasshi 46:411-5. 2008
    ..There was a tendency toward increasing lymphocytes and high CD4/CD8 ratio in bronchoalveolar lavage fluids. Treatment with steroids seems to have a limited effect, while avoidance of the antigen is important...
  75. doi Effects of single or repeated amphetamine treatment and withdrawal on lung allergic inflammation in rats
    A P Ligeiro de Oliveira
    Department of Pharmacology, Biomedical Sciences Institute, University of Sao Paulo, Sao Paulo, Brazil
    Int Immunopharmacol 8:1164-71. 2008
    ..The possible involvement of vesicular monoamine transporter type 2 (VMAT2) with these observed effects was discussed...
  76. ncbi Diagnosis of usual interstitial pneumonia and distinction from other fibrosing interstitial lung diseases
    Anna Luise A Katzenstein
    Departments of Pathology at SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Hum Pathol 39:1275-94. 2008
    ..This review is an attempt to clarify the diagnostic pathologic features of usual interstitial pneumonia and to provide guidelines for its distinction from other interstitial lung diseases that enter the differential diagnosis...
  77. ncbi [Spinach powder-induced exogenous allergic alveolitis]
    J Schreiber
    Forschungszentrum Borstel, Medizinische Klinik
    Pneumologie 52:61-5. 1998
    ..24 hours after exposure bronchoalveolar lavage showed an increase of neutrophils. In lung parenchyma mononuclear interstitial infiltrates and an epitheloid cell granuloma were seen...
  78. ncbi Blockade of leukocyte function-associated antigen (LFA-1) in a murine model of lung inflammation
    M Denis
    Pulmonary Research Unit, Faculty of Medicine, University of Sherbrooke, Canada
    Am J Respir Cell Mol Biol 10:481-6. 1994
    ..From these results, we conclude that the fibrosis and tissue-damaging reactions in hypersensitivity pneumonitis, but not the alveolitis, are partly dependent on LFA-1-mediated cellular interactions.(ABSTRACT TRUNCATED AT 250 WORDS)..
  79. ncbi [Exogenous allergic alveolitis: 22 year follow-up of malt worker's lung]
    H Thomas
    St. Elisabeth-Krankenhauses Dorsten
    Pneumologie 49:32-4. 1995
    ..Reasons are being sought for the failure of all other diagnostic methods to diagnose exogenous allergic alveolitis. The disease is distinguished from the "organic dust toxic syndrome" by differential diagnosis...
  80. ncbi Elevated levels of thymus- and activation-regulated chemokine in bronchoalveolar lavage fluid from patients with eosinophilic pneumonia
    Eishi Miyazaki
    Third Department of Internal Medicine, Oita Medical University, Oita, Japan
    Am J Respir Crit Care Med 165:1125-31. 2002
    ..Our results, in concordance with previous studies, demonstrate the potential activity of TARC for recruiting Th2 cells to the lungs and suggest a significant role for TARC in the pathogenesis of eosinophilic pneumonia...
  81. ncbi Nonspecific interstitial pneumonitis as the sole histologic expression of hypersensitivity pneumonitis
    Jason S Vourlekis
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
    Am J Med 112:490-3. 2002
  82. ncbi Thrombin-activatable fibrinolysis inhibitor and protein C inhibitor in interstitial lung disease
    Hajime Fujimoto
    Respiratory Division, Third Department of Internal Medicine, Mie University School of Medicine, Edobashi 2 174, Tsu City, Mie 514 8507, Japan
    Am J Respir Crit Care Med 167:1687-94. 2003
    ..Overall, these findings suggest that thrombin-activatable fibrinolysis inhibitor and protein C inhibitor may play important roles in the mechanism of intraalveolar hypofibrinolysis associated with interstitial lung diseases...
  83. ncbi Cytokine mRNA expression in isocyanate-induced hypersensitivity pneumonitis
    Yuki Sumi
    The Pulmonary Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Respiration 70:284-91. 2003
    ..Diisocyanate is widely used as a polymerizing agent for manufacturing many products. However, repeated inhalation exposure to diisocyanates in the workplace can cause bronchial asthma, hypersensitivity pneumonitis (HP), and neoplasia...
  84. ncbi [Guidelines for diagnosing extrinsic allergic alveolitis (hypersensitivity pneumonitis) (German Extrinsic Allergic Alveolitis Study Group)]
    J Sennekamp
    Die Institutsangaben sind am Ende des Beitrags gelistet
    Pneumologie 61:52-6. 2007
  85. ncbi What the allergist should know about hypersensitivity pneumonitis
    Raymond G Slavin
    Division of Allergy and Immunology, Department of Internal Medicine, Saint Louis University School of Medicine, Missouri 63104, USA
    Allergy Asthma Proc 28:25-7. 2007
    ..The immunopathogenesis appears to represent a combination of type III and IV immune responses. Identifying the offending antigen is vital so that appropriate environmental precautions can be carried out...
  86. ncbi Local and circulating microchimerism is associated with hypersensitivity pneumonitis
    Martha L Bustos
    Instituto Nacional de Enfermedades Respiratorias, Mexico, DF, Mexico
    Am J Respir Crit Care Med 176:90-5. 2007
    ..Microchimerism has been implicated in the pathogenesis of autoimmune diseases, especially in those showing increased incidence after childbearing age...
  87. ncbi [Clinical research in the field of occupational diseases (pneumonology aspects)]
    G Rivolta
    Dipartimento di Medicina del Lavoro Clinica del Lavoro Luigi Devoto, Universita degli Studi di Milano, Azienda Ospedaliera Istituti Clinici di Perfezionamento di Milano
    Med Lav 94:59-63. 2003
    ..In extrinsic allergic alveolitis, we noted the presence of a large lymphocytic alveolitis mostly with CD4+/CD8+ reverse ratio, ..
  88. ncbi Mushroom worker's lung: organic dust exposure in the spawning shed
    Ryan F Hoy
    Department of Respiratory and Sleep Medicine, Austin Health, Melbourne, Victoria, Australia
    Med J Aust 186:472-4. 2007
    ..With absence from the workplace and no steroid therapy, the symptoms of both patients subsided and the results of lung function tests and CT scans improved markedly...
  89. ncbi Bronchoalveolar lavage in interstitial lung diseases: does the recovery rate affect the results?
    J Schildge
    Abteilung Pneumologie, Medizinische Klinik, St Vincentius Kliniken Karlsruhe, Karlsruhe, Germany
    Respiration 74:553-7. 2007
    ..Bronchoalveolar lavage (BAL) is an established diagnostic tool in interstitial lung diseases. BAL frequently yields findings of diagnostic value and at times even confirmatory diagnostic results...
  90. ncbi [Chronic hypersensitivity pneumonitis complicated by recurrent pneumothorax]
    Naomi Yamasaki
    Research Institute for Diseases of the Chest, Graduate School of Medical Science, Kyushu University, Fukuoka
    Nihon Naika Gakkai Zasshi 92:310-2. 2003
  91. ncbi Radiology of acute diffuse lung disease in the immunocompetent host
    Loren Ketai
    Department of Radiology, UNMHSC, 915 Camino de Salud, Albuquerque, NM 87131 5336, USA
    Semin Roentgenol 37:25-36. 2002
  92. ncbi Hypersensitivity pneumonitis
    Eunhee S Yi
    Department of Pathology, University of California, San Diego, School of Medicine, San Diego 92103 8720, CA, USA
    Crit Rev Clin Lab Sci 39:581-629. 2002
    ....
  93. ncbi Expansion of pulmonary CD8+CD56+ natural killer T-cells in hypersensitivity pneumonitis
    Peter Korosec
    Laboratory of Immunology and Molecular Biology, University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia
    Chest 132:1291-7. 2007
    ..Natural killer T (NKT) cells, a newly identified subgroup of T cells with immunoregulatory function, may be implicated in the pathogenesis of interstitial lung disease (ILD)...
  94. ncbi Granuloma associated with Trichosporon asahii infection in the lung: Unusual pathological findings and PCR detection of Trichosporon DNA
    Masamitsu Nakajima
    Faculty of Health Science, Hiroshima International University, Kurose Higashihiroshima, Japan
    Med Mycol 45:641-4. 2007
    ..This case suggests that Trichosporon infection may develop into granuloma with multinucleated giant cells...
  95. ncbi Expression of sarcoidosis related genes in lung lavage cells
    Rene Thonhofer
    Laboratories for Molecular Cytogenetics, Environmental and Respiratory Pathology, Institute of Pathology, Karl Franzens University of Graz, Austria
    Sarcoidosis Vasc Diffuse Lung Dis 19:59-65. 2002
    ..Mycobacterial DNA has been found in about 30% of sarcoidosis patients within the granulomas, which has been interpreted as a probable trigger mechanism...
  96. ncbi Airborne fungi in industrial environments--potential agents of respiratory diseases
    Albinas Lugauskas
    Institute of Botany, Zaliuju ezeru 49, LT 2021 Vilnius, Lithuania
    Ann Agric Environ Med 11:19-25. 2004
    ..the identified fungal species are characterized as allergenic and an exposure to their spores may provoke adverse health effects (such as allergic rhinitis, bronchial asthma or extrinsic allergic alveolitis) in susceptible individuals.
  97. ncbi Avian circoviruses of the genus Circovirus: A potential trigger in Pigeon breeder's lung (PBL)/Bird fancier's lung (BFL)
    Petros A Bougiouklis
    Clinic of Avian Medicine, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, St Voutira 11, 54627 Thessaloniki, Hellas Greece
    Med Hypotheses 68:320-3. 2007
    Pigeon breeder's lung (PBL) or Bird fancier's lung (BFL) is one of the most common extrinsic allergic alveolitis or hypersensitivity pneumonitis...
  98. ncbi [Dental technician's pneumoconiosis; a case report]
    Canan Karaman Eyüboğlu
    Department of Chest Diseases, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey
    Tuberk Toraks 56:204-9. 2008
    Since 1939, it has been known that, silicosis and extrinsic allergic alveolitis can be seen among dental technicians...
  99. ncbi [Isocyanates: occupational exposures and disorders]
    X Baur
    Ordinariat und Zentralinstitut für Arbeitsmedizin, Universitat Hamburg, Germany
    Pneumologie 57:526-31. 2003
    ..Obstructive airway diseases are the major disorder caused by isocyanates. Rare cases suffer from extrinsic allergic alveolitis or eczema...
  100. ncbi Leukotrienes, LTC4 and LTB4, in bronchoalveolar lavage in bronchial asthma and other respiratory diseases
    A J Wardlaw
    Department of Allergy, Cardiothoracic Institute, London, England
    J Allergy Clin Immunol 84:19-26. 1989
    ..fibrosing alveolitis [CFA] or idiopathic pulmonary fibrosis), three with sarcoidosis, one with extrinsic allergic alveolitis, one with sulphonamide-induced pneumonia, and one patient with eosinophilic granuloma...
  101. doi Induced sputum in interstitial lung diseases: novel insights in the diagnosis, evaluation and research
    Foteini Economidou
    Department of Thoracic Medicine, University of Crete Medical School, Heraklion, Greece
    Respiration 77:351-8. 2009
    ..applications of IS in the assessment of fibrotic and granulomatous diseases such as sarcoidosis and extrinsic allergic alveolitis, idiopathic pulmonary fibrosis, connective tissue disorders, occupational lung diseases and other ..

Research Grants50

  1. The Role of Neutrophils in Hypersensitivity Pneumonitis
    Elizabeth Fitzpatrick; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Hypersensitivity Pneumonitis (HP), or extrinsic allergic alveolitis, is an interstitial lung disease that develops following repeated exposure to inhaled environmental antigens...
  2. The Role of Neutrophils in Hypersensitivity Pneumonitis
    ELIZABETH ANN FITZPATRICK; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hypersensitivity Pneumonitis (HP), or extrinsic allergic alveolitis, is an interstitial lung disease that develops following repeated exposure to inhaled environmental antigens...
  3. The Role of Neutrophils in Hypersensitivity Pneumonitis
    Elizabeth Fitzpatrick; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Hypersensitivity Pneumonitis (HP), or extrinsic allergic alveolitis, is an interstitial lung disease that develops following repeated exposure to inhaled environmental antigens...
  4. The Role of Neutrophils in Hypersensitivity Pneumonitis
    Elizabeth Fitzpatrick; Fiscal Year: 2007
    Hypersensitivity Pneumonitis (HP), or extrinsic allergic alveolitis, is an interstitial lung disease that develops following repeated exposure to inhaled environmental antigens...
  5. Interleukin-4 effects on calcium in airway smooth muscle
    JOHN MADISON; Fiscal Year: 2005
    ..Studies will be done with freshly-dispersed bovine and cultured human airway smooth muscle cells. ..
  6. Novel Therapeutic Approaches in IPF
    Fernando Martinez; Fiscal Year: 2005
    ..These protocols will define the role of standard therapy, test the efficacy of targeted combination therapy, and explore the promise of a novel approach to the design and delivery of therapeutic agents for IPF. (End of Abstract) ..
  7. Exposure Intervention in a Rural Pediatric Asthma Cohort
    Peter Thorne; Fiscal Year: 2004
    ..Detailed health and home hygiene questionnaires and home inspections will be conducted at baseline and one year later, as will child spirometry. ..
  8. Interleukin-4 effects on calcium in airway smooth muscle
    JOHN MADISON; Fiscal Year: 2004
    ..Studies will be done with freshly-dispersed bovine and cultured human airway smooth muscle cells. ..
  9. Strategies to Prevent COPD Exacerbation
    Fernando Martinez; Fiscal Year: 2004
    ..abstract_text> ..
  10. Exposure Intervention in a Rural Pediatric Asthma Cohort
    Peter Thorne; Fiscal Year: 2003
    ..Detailed health and home hygiene questionnaires and home inspections will be conducted at baseline and one year later, as will child spirometry. ..
  11. Interleukin-4 effects on calcium in airway smooth muscle
    JOHN MADISON; Fiscal Year: 2003
    ..Studies will be done with freshly-dispersed bovine and cultured human airway smooth muscle cells. ..
  12. Exposure Intervention in a Rural Pediatric Asthma Cohort
    Peter Thorne; Fiscal Year: 2005
    ..Detailed health and home hygiene questionnaires and home inspections will be conducted at baseline and one year later, as will child spirometry. ..
  13. Novel Therapies in Idiopathic Pulmonary Fibrosis
    Fernando Martinez; Fiscal Year: 2007
    ..This will become particularly important if translational research is to keep pace as strides are made in the basic immunology, genetics and biochemistry of IPF. ..
  14. ENVIRONMENTAL HEALTH SCIENCES RESEARCH CENTER
    Peter Thorne; Fiscal Year: 2008
    ..ESSENTIAL CHARACTERISTICS Strategic Vision and Impact on Environmental Health ..
  15. ENVIRONMENTAL HEALTH SCIENCES RESEARCH CENTER
    Peter Thorne; Fiscal Year: 2008
    ..ESSENTIAL CHARACTERISTICS Strategic Vision and Impact on Environmental Health ..
  16. Novel Therapeutic Approaches in IPF
    Fernando Martinez; Fiscal Year: 2008
    ..These protocols will define the role of standard therapy, test the efficacy of targeted combination therapy, and explore the promise of a novel approach to the design and delivery of therapeutic agents for IPF. (End of Abstract) ..
  17. Strategies to Prevent COPD Exacerbation
    Fernando Martinez; Fiscal Year: 2007
    ..abstract_text> ..
  18. Novel Therapies in Idiopathic Pulmonary Fibrosis
    Fernando Martinez; Fiscal Year: 2008
    ..This will become particularly important if translational research is to keep pace as strides are made in the basic immunology, genetics and biochemistry of IPF. ..
  19. Novel Therapeutic Approaches in IPF
    Fernando Martinez; Fiscal Year: 2007
    ..These protocols will define the role of standard therapy, test the efficacy of targeted combination therapy, and explore the promise of a novel approach to the design and delivery of therapeutic agents for IPF. (End of Abstract) ..
  20. ENVIRONMENTAL HEALTH SCIENCES RESEARCH CENTER
    Peter Thorne; Fiscal Year: 2007
    ..ESSENTIAL CHARACTERISTICS Strategic Vision and Impact on Environmental Health ..
  21. LINKING OCCUPATIONAL INJURY AND ILLNESS DATA BASES
    Kenneth Rosenman; Fiscal Year: 2002
    ..We have assembled an interdisciplinary team consisting of an occupational health physician, epidemiologists, a biostatistician and a computer programmer. We have arranged access to all nine data systems. ..
  22. IMMUNOPATHOGENESIS OF ALLERGIC ASPERGILLOSIS
    RAYMOND SLAVIN; Fiscal Year: 2003
    ..abstract_text> ..
  23. CALCIUM REGULATION IN SINGLE AIRWAY SMOOTH MUSCLE CELLS
    JOHN MADISON; Fiscal Year: 2000
    ..To address these aims, the principal method is radiometric imaging of [Ca2+]i in single, bovine airway smooth muscle cells loaded with the calcium dye, fura-2. ..
  24. IMMUNOPATHOGENESIS OF ALLERGIC ASPERGILLOSIS
    RAYMOND SLAVIN; Fiscal Year: 2000
    ....
  25. PULMONARY SURFACTANT EFFECTS ON THE MACROPHAGE PHENOTYPE
    DAVID PHELPS; Fiscal Year: 1999
    ..The object of these experiments is to confirm that the responses we are obtaining with the in vitro studies resemble the responses of actual immune cells. The volunteers are being used as a source of normal cells. ..
  26. INHALED PARTICLE CHARACTERISTICS AND EARLY LUNG EFFECTS
    William Beckett; Fiscal Year: 2000
    ..We anticipate that the results will help to determine whether there are differential effects for equal mass exposures to fine particles of different size fractions in the pathogenesis of COPD ..
  27. CALCIUM REGULATION IN SINGLE AIRWAY SMOOTH MUSCLE CELLS
    JOHN MADISON; Fiscal Year: 1999
    ..To address these aims, the principal method is radiometric imaging of [Ca2+]i in single, bovine airway smooth muscle cells loaded with the calcium dye, fura-2. ..
  28. IMMUNOPATHOGENESIS OF ALLERGIC ASPERGILLOSIS
    RAYMOND SLAVIN; Fiscal Year: 1999
    ....
  29. PULMONARY SURFACTANT EFFECTS ON THE MACROPHAGE PHENOTYPE
    DAVID PHELPS; Fiscal Year: 2000
    ..The object of these experiments is to confirm that the responses we are obtaining with the in vitro studies resemble the responses of actual immune cells. The volunteers are being used as a source of normal cells. ..
  30. LINKING OCCUPATIONAL INJURY AND ILLNESS DATA BASES
    Kenneth Rosenman; Fiscal Year: 2000
    ..We have assembled an interdisciplinary team consisting of an occupational health physician, epidemiologists, a biostatistician and a computer programmer. We have arranged access to all nine data systems. ..
  31. IMMUNOPATHOGENESIS OF ALLERGIC ASPERGILLOSIS
    RAYMOND SLAVIN; Fiscal Year: 2001
    ....
  32. Genetic/Exposure Interaction in Beryllium Disease
    Kenneth Rosenman; Fiscal Year: 2003
    ..0% of the cohort has developed these changes. The results of this study will help to elucidate the underlying mechanism of beryllium sensitization and chronic disease. ..
  33. PULMONARY SURFACTANT EFFECTS ON THE MACROPHAGE PHENOTYPE
    DAVID PHELPS; Fiscal Year: 2002
    ..The object of these experiments is to confirm that the responses we are obtaining with the in vitro studies resemble the responses of actual immune cells. The volunteers are being used as a source of normal cells. ..
  34. INHALED PARTICLE CHARACTERISTICS AND EARLY LUNG EFFECTS
    William Beckett; Fiscal Year: 2002
    ..We anticipate that the results will help to determine whether there are differential effects for equal mass exposures to fine particles of different size fractions in the pathogenesis of COPD ..
  35. Exposure Intervention in a Rural Pediatric Asthma Cohort
    Peter Thorne; Fiscal Year: 2002
    ..Detailed health and home hygiene questionnaires and home inspections will be conducted at baseline and one year later, as will child spirometry. ..
  36. LINKING OCCUPATIONAL INJURY AND ILLNESS DATA BASES
    Kenneth Rosenman; Fiscal Year: 2001
    ..We have assembled an interdisciplinary team consisting of an occupational health physician, epidemiologists, a biostatistician and a computer programmer. We have arranged access to all nine data systems. ..
  37. Exposure Intervention in a Rural Pediatric Asthma Cohort
    Peter Thorne; Fiscal Year: 2001
    ..Detailed health and home hygiene questionnaires and home inspections will be conducted at baseline and one year later, as will child spirometry. ..
  38. Interleukin-4 effects on calcium in airway smooth muscle
    JOHN MADISON; Fiscal Year: 2002
    ..Studies will be done with freshly-dispersed bovine and cultured human airway smooth muscle cells. ..
  39. PULMONARY SURFACTANT EFFECTS ON THE MACROPHAGE PHENOTYPE
    DAVID PHELPS; Fiscal Year: 2001
    ..The object of these experiments is to confirm that the responses we are obtaining with the in vitro studies resemble the responses of actual immune cells. The volunteers are being used as a source of normal cells. ..
  40. INHALED PARTICLE CHARACTERISTICS AND EARLY LUNG EFFECTS
    William Beckett; Fiscal Year: 2001
    ..We anticipate that the results will help to determine whether there are differential effects for equal mass exposures to fine particles of different size fractions in the pathogenesis of COPD ..