Research Topics
Genomes and Genes
Species | common coldSummarySummary: A catarrhal disorder of the upper respiratory tract, which may be viral, a mixed infection, or an allergic reaction. It is marked by acute coryza, slight rise in temperature, chilly sensations, and general indisposition. (Dorland, 27th ed) Top Publications
Research Grants
| Scientific Experts
|
Detail Information
Publications
Duration and severity of symptoms and levels of plasma interleukin-1 receptor antagonist, soluble tumor necrosis factor receptor, and adhesion molecules in patients with common cold treated with zinc acetateAnanda S Prasad
Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
J Infect Dis 197:795-802. 2008Zinc lozenges have been used for treatment of the common cold; however, the results remain controversial.
Sleep habits and susceptibility to the common coldSheldon Cohen
Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
Arch Intern Med 169:62-7. 2009Sleep quality is thought to be an important predictor of immunity and, in turn, susceptibility to the common cold. This article examines whether sleep duration and efficiency in the weeks preceding viral exposure are associated with cold ..
Rhinovirus-induced airway inflammation in asthma: effect of treatment with inhaled corticosteroids before and during experimental infectionK Grunberg
Department of Pulmonology, Department of Medical Decision Making, Leiden University Medical Center LUMC, Leiden, The Netherlands
Am J Respir Crit Care Med 164:1816-22. 2001..The latter finding is in keeping with the limited protection of inhaled corticosteroids against acute asthma exacerbations...
Antibiotic prescribing for adults with colds, upper respiratory tract infections, and bronchitis by ambulatory care physiciansR Gonzales
Division of General Internal Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
JAMA 278:901-4. 1997..How frequently antibiotics are prescribed for these conditions and for and by whom is not known...
Relations among questionnaire and laboratory measures of rhinovirus infectionB Barrett
University of Wisconsin Medical School, 777 S Mills, Madison, WI 53715, USA
Eur Respir J 28:358-63. 2006..The inclusion of functional and quality-of-life items in the Wisconsin Upper Respiratory Symptom Survey does not significantly decrease the strength of association with laboratory-assessed biomarkers...
Transmission of viral respiratory infections in the homeD A Goldmann
Department of Medicine Children s Hospital, Boston, MA 02115, USA
Pediatr Infect Dis J 19:S97-102. 2000..study, from the plains of Salisbury, to the hills of Virginia, to the collegiate environment of Madison, WI, the precise routes rhinovirus takes to inflict the misery of the common cold on a susceptible population remain controversial.
Echinacea for prevention of the common cold: an illustrative overview of how information from different systematic reviews is summarised on the internetAnna Hart
School of Public Health and Clinical Sciences, University of Central Lancashire, Harrington Building, Adelphi Street, Preston, Lancashire, PR1 2HE, UK
Prev Med 49:78-82. 2009..Our study objectives were to illustrate how selection criteria for trials in each of the reviews could lead to different conclusions, and to classify the ways in which webpage authors use the reviews to construct advice about echinacea...
Visits by adults to family physicians for the common coldW J McIsaac
Mt Sinai Family Medicine Centre, Toronto, Ontario, Canada
J Fam Pract 47:366-9. 1998..We examined how often a large population of adults visited doctors when they had a cold, the degree to which they engaged in self care, and the characteristics of those seeking care...
Vitamin C and acute respiratory infectionsH Hemilä
Department of Public Health, University of Helsinki, Finland
Int J Tuberc Lung Dis 3:756-61. 1999So far over 60 studies have examined the effects of vitamin C on the common cold. No effect on common cold incidence was observed in the six largest studies, indicating that vitamin C has no preventive effects in normally nourished ..
A clinical trial of hypertonic saline nasal spray in subjects with the common cold or rhinosinusitisP Adam
Riverside University Family Practice Clinic, University of Minnesota Department of Family Practice and Community Health, Minneapolis 55406, USA
Arch Fam Med 7:39-43. 1998To determine whether hypertonic saline nasal spray relieves nasal symptoms and shortens illness duration in patients with the common cold or acute rhinosinusitis.
Evidence for correlation of objective and subjective measures of nasal airflow in patients with common coldJ D Clarke
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, Cardiff, UK
Clin Otolaryngol 30:35-8. 2005..To utilize posterior rhinomanometry and conductance, as units of measurement, to further investigate the relationship between subjective and objective measures of nasal airflow...
Echinacea for preventing and treating the common coldKarin Woelkart
Institute of Pharmaceutical Sciences, Department of Pharmacognosy, Karl Franzens University, Graz, Austria
Planta Med 74:633-7. 2008Echinacea preparations are widely used for common cold. Many consumers and healthcare professionals are not aware that products available under the term Echinacea may differ in their composition, due to the use of different species, ..
Nasal inflammation induced by a common cold: comparison between controls and patients with nasal polyposis under topical steroid therapyC Dassonville
Laboratory of Public Health and Environment, Faculty of Pharmacy, University Paris V, Paris
Acta Otorhinolaryngol Ital 27:78-82. 2007The evolution of nasal inflammation during a common cold in patients with nasal polyposis under topical steroid treatment is not clearly defined in the literature...
Inflammatory changes during the 'common cold' are associated with platelet activation and increased reactivity of platelets to agonistsRolf P Kreutz
Sinai Center for Thrombosis Research, Baltimore, Maryland 21215, USA
Blood Coagul Fibrinolysis 18:713-8. 2007..We hypothesized that changes in platelet activation and reactivity and inflammation occur during the 'common cold'. Previously healthy individuals with viral upper respiratory tract infections were studied (n = 18)...
[Cough induction by high-frequency chest percussion in healthy volunteers and patients with common cold]P C L Lee
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, UK
Respir Med 98:771-6. 2004..This method of inducing cough in subjects with URTI may be useful for studies on the mechanism of cough and for studies on antitussive medicines...
Zinc lozenges as cure for the common cold--a review and hypothesisGeorge A Eby
Director of Research, George Eby Research Institute, 14909 C Fitzhugh Road, Austin, TX 78736, USA
Med Hypotheses 74:482-92. 2010..the iZn hypothesis, lozenge iZn and total daily iZn in trials were found highly correlated with reductions in common cold durations with statistical significance for mean duration (P<0.001) and median duration (P<0...
Echinacea purpurea therapy for the treatment of the common cold: a randomized, double-blind, placebo-controlled clinical trialSteven H Yale
Department of Internal Medicine, Marshfield Clinic, and the Biostatistics and Bioinformatics Core, Marshfield Clinic Research Foundation, Marshfield, WI 54449, USA
Arch Intern Med 164:1237-41. 2004..We sought to determine the efficacy of a standardized preparation of E purpurea in reducing symptom severity and duration of the common cold.
Echinacea for treating the common cold: a randomized trialBruce Barrett
Department of Family Medicine, University of Wisconsin, Madison, Wisconsin 53715, USA
Ann Intern Med 153:769-77. 2010Echinacea is widely used to treat the common cold.
Mechanisms of symptoms of the common cold and influenzaRon Eccles
Common Cold Centre, Cardiff University, Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US
Br J Hosp Med (Lond) 68:71-5. 2007
Willingness to pay for health care services in common cold, retinal detachment, and myocardiac infarction: an internet survey in JapanHideo Yasunaga
Department of Planning, Information and Management, University of Tokyo Hospital, Tokyo, Japan
BMC Health Serv Res 6:12. 2006..The objective of this survey is to measure WTP for the treatment of typical acute illnesses and to analyze the factors affecting WTP...
Effect of Lactobacillus gasseri PA 16/8, Bifidobacterium longum SP 07/3, B. bifidum MF 20/5 on common cold episodes: a double blind, randomized, controlled trialMichael de Vrese
Institute for Physiology and Biochemistry of Nutrition, Federal Research Centre of Nutrition and Food, Hermann Weigmann Strasse 1, D 24103 Kiel, Germany
Clin Nutr 24:481-91. 2005..bifidum MF 20/5 (5 x 10(7) cfu/tablet) during at least 3 months influences the severity of symptoms and the incidence and duration of the common cold.
Efficacy of Echinacea purpurea in patients with a common cold. A placebo-controlled, randomised, double-blind clinical trialB Schulten
Company Medical Service, Madaus AG, Cologne, Germany
Arzneimittelforschung 51:563-8. 2001..Echinaceae purpureae herba (Echinacin, EC31J0) has shown promising results in the relief of common cold symptoms and the time taken to improvement compared to placebo...
The prophylactic and therapeutic effectiveness of zinc sulphate on common cold in childrenZafer Kurugol
Department of Paediatrics, Faculty of Medicine, Ege University, Izmir, Turkey
Acta Paediatr 95:1175-81. 2006To determine the efficacy of prophylactic administration of zinc sulphate in reducing the occurrence of the common cold in children, and to evaluate the efficacy of zinc sulphate in reducing the duration and severity of cold symptoms.
Nitric oxide and the common coldDavid Proud
Respiratory Research Group and Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
Curr Opin Allergy Clin Immunol 5:37-42. 2005The common cold is a clinical syndrome triggered by a variety of viral pathogens, but rhinoviruses are the most frequent cause...
Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort studyJonathan M Corne
University Medicine, Southampton General Hospital, Southampton, UK
Lancet 359:831-4. 2002..Rhinovirus infections cause exacerbations of asthma. We postulated that people with asthma are more susceptible to rhinovirus infection than people without the disease and compared the susceptibility of these groups...
Psychological job demands as a risk factor for common cold in a Dutch working populationD C Mohren
Department of Epidemiology, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands
J Psychosom Res 50:21-7. 2001We investigated the effect of Psychological Job Demands (PJD) on the occurrence of the clinical symptoms of common cold.
Productivity losses related to the common coldThomas J Bramley
J Occup Environ Med 44:822-9. 2002..We conclude that the economic cost of lost productivity due to the common cold approaches $25 billion, of which $16...
Vitamin C for preventing and treating the common coldRobert M Douglas
National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australia
PLoS Med 2:e168; quiz e217. 2005
Comparison of anchor-based and distributional approaches in estimating important difference in common coldBruce Barrett
Department of Family Medicine, University of Wisconsin Medical School, 777 South Mills, Madison, WI 53715, USA
Qual Life Res 17:75-85. 2008..Several approaches to minimal important difference (MID) and responsiveness have been developed...
Effects of rhinovirus infection on histamine and cytokine production by cell lines from human mast cells and basophilsMasayoshi Hosoda
Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan
J Immunol 169:1482-91. 2002..These findings suggest that RV14 infection may prime the cytokine and histamine production from mast cells and basophils and may cause airway inflammation in asthma...
Rationale and methods for a trial assessing placebo, echinacea, and doctor-patient interaction in the common coldBruce Barrett
Department of Family Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA
Explore (NY) 3:561-72. 2007..DESIGN: This trial uses two-way factorial allocation to randomize people with new onset common cold in two directions: pill related and doctor related...
The common coldTerho Heikkinen
Department of Paediatrics, Turku University Hospital, Turku, Finland
Lancet 361:51-9. 2003Despite great advances in medicine, the common cold continues to be a great burden on society in terms of human suffering and economic losses. Of the several viruses that cause the disease, the role of rhinoviruses is most prominent...
Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteersFrederick G Hayden
Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
Antimicrob Agents Chemother 47:3907-16. 2003..Results from these studies in experimental rhinoviral infection support continued investigation of intranasal ruprintrivir in the setting of natural HRV infection...
Evaluation of echinacea for the prevention and treatment of the common cold: a meta-analysisSachin A Shah
University of Connecticut School of Pharmacy, Storrs, CT, USA
Lancet Infect Dis 7:473-80. 2007..commonly used herbal products, but controversy exists about its benefit in the prevention and treatment of the common cold. Thus, we did a meta-analysis evaluating the effect of echinacea on the incidence and duration of the common ..
Sociability and susceptibility to the common coldSheldon Cohen
Carnegie Mellon University, Pittsburgh, PA 15213, USA
Psychol Sci 14:389-95. 2003..They were subsequently exposed to a virus that causes a common cold and monitored to see who developed verifiable illness...
Emotional style and susceptibility to the common coldSheldon Cohen
Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213 3890, USA
Psychosom Med 65:652-7. 2003..We tested these hypotheses for host resistance to the common cold.
New considerations in the treatment and prevention of rhinovirus infectionsRonald B Turner
University of Virginia School of Medicine, Department of Pediatrics, Charlottesville, VA 22908, USA
Pediatr Ann 34:53-7. 2005..Although these infections are most closely associated with the common cold, recent studies have established the rhinoviruses as important causes of other upper and lower respiratory ..
Using benefit harm tradeoffs to estimate sufficiently important difference: the case of the common coldBruce Barrett
Department of Family Medicine, University of Wisconsin Medical School, Madison, WI 53715, USA
Med Decis Making 25:47-55. 2005..Little is known about patient preferences regarding benefits and harms of common cold treatments.
Increase in common cold symptoms and mouth ulcers following smoking cessationM Ussher
Department of Psychology, St George s Hospital Medical School, University of London, UK
Tob Control 12:86-8. 2003To examine changes in reports of common cold symptoms and mouth ulcers following smoking cessation. It was hypothesised that reports of these symptoms would increase on stopping smoking.
Efficacy and safety of single and multiple doses of pseudoephedrine in the treatment of nasal congestion associated with common coldRonald Eccles
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, United Kingdom
Am J Rhinol 19:25-31. 2005..taken in tablet or syrup formulations every 4-6 hours for the treatment of nasal congestion associated with common cold and allergy...
Human rhinovirus infection induces airway epithelial cell production of human beta-defensin 2 both in vitro and in vivoDavid Proud
Respiratory Research Group and Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
J Immunol 172:4637-45. 2004..This represents the first demonstration that HRV infection induces epithelial expression of HBD-2 both in vitro and in vivo, and supports the concept that HBD-2 may play a role in host defense to HRV infection...
Vitamin C, vitamin E, and beta-carotene in relation to common cold incidence in male smokersHarri Hemilä
Department of Public Health, Universityof Helsinki, Finland
Epidemiology 13:32-7. 2002..E, and beta-carotene, as well as long-term vitamin E and beta-carotene supplementation, on the incidence of common cold episodes...
Viruses and bacteria in the etiology of the common coldM J Mäkelä
Department of Pediatrics, University of Turku, Finland
J Clin Microbiol 36:539-42. 1998..The results show that although approximately 50% of episodes of the common cold were caused by rhinoviruses, the etiology can vary depending on the epidemiological situation with regard to ..
The treatment of rhinovirus infections: progress and potentialR B Turner
Department of Pediatrics, Medical University of South Carolina, Clinical Sciences Building, Room 312, 171 Ashley Avenue, Charleston, SC 29425, USA
Antiviral Res 49:1-14. 2001The common cold is an important illness both as a result of the economic impact of this common disease and because of the morbidity associated with the complications of the illness...
Rhinovirus transmission within families with children: incidence of symptomatic and asymptomatic infectionsVille Peltola
Department of Pediatrics, Turku University Hospital, Turku, Finland
J Infect Dis 197:382-9. 2008..Rhinoviruses are the most common cause of respiratory tract infections, but the transmission in families has not been studied using sensitive and specific molecular detection methods...
Efficacy of tremacamra, a soluble intercellular adhesion molecule 1, for experimental rhinovirus infection: a randomized clinical trialR B Turner
Department of Pediatrics, Medical University of South Carolina, Charleston 29425, USA
JAMA 281:1797-804. 1999..Attachment of most rhinovirus subtypes to cells depends on a cellular receptor, the intercellular adhesion molecule 1 (ICAM-1). A recombinant soluble ICAM-1 (tremacamra, formerly BIRR 4) has shown possible efficacy in early studies...
Relationship of upper and lower airway cytokines to outcome of experimental rhinovirus infectionJ E Gern
Department of Pediatrics, University of Wisconsin Medical School, Madison, Wisconsin 53792 4108, USA
Am J Respir Crit Care Med 162:2226-31. 2000..cell type 1 (Th1)- and Th2-like cytokines induced by RV infection may help determine the clinical outcome of common cold infections, raising the possibility that the individual subject's immune response, rather than atopic status ..
Dynamics of stress-related decrease of salivary immunoglobulin A (sIgA): relationship to symptoms of the common cold and studying behaviorR Deinzer
Institute for Medical Psychology, Heinrich Heine University of Dusseldorf, Germany
Behav Med 23:161-9. 1998..However, no relationship between sIgA and URT symptoms was observed, nor did students who took academic examinations differ from untested controls in symptom rates...
Weekly monitoring of children with asthma for infections and illness during common cold seasonsJaime P Olenec
Department of Pediatrics, University of Wisconsin, Madison, WI 53792 4108, USA
J Allergy Clin Immunol 125:1001-1006.e1. 2010..Exacerbations of childhood asthma and rhinovirus infections both peak during the spring and fall, suggesting that viral infections are major contributors to seasonal asthma morbidity...
Saline nasal irrigation for acute upper respiratory tract infectionsJessica C Kassel
School of Population Health, University of Queensland, Brisbane, Australia
Cochrane Database Syst Rev 3:CD006821. 2010BACKGROUND: Acute upper respiratory tract infections (URTIs), including the common cold and rhinosinusitis, are common afflictions that cause discomfort and debilitation, and contribute significantly to workplace absenteeism...
Population-based case-control study of the common cold during pregnancy and congenital abnormalitiesNandor Acs
Second Department of Obstetrics and Gynecology, School of Medicine, Semmelweis University, Budapest, Hungary
Eur J Epidemiol 21:65-75. 2006The common cold is the most frequent maternal disease during pregnancy...
Patient beliefs about the characteristics, causes, and care of the common cold: an updateB L Braun
Health Research Center, Institute for Research and Education, HealthSystem Minnesota, Minneapolis 55416, USA
J Fam Pract 49:153-6. 2000..Many people seek medical care for cold symptoms. The cold-related knowledge and beliefs of adults seeking medical care for themselves or their children may not correspond with current medical opinion...
Epidemiological relationships between the common cold and exacerbation frequency in COPDJ R Hurst
Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, Hampstead, London, NW3 2QG, UK
Eur Respir J 26:846-52. 2005..Exacerbation frequency in chronic obstructive pulmonary disease is associated with an increased frequency of acquiring the common cold, rather than an increased propensity to exacerbation once a cold has been acquired.
The human rhinovirus: human-pathological impact, mechanisms of antirhinoviral agents, and strategies for their discoveryJudith M Rollinger
Institute of Pharmacy Pharmacognosy and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 52c, A 6020 Innsbruck, Austria
Med Res Rev 31:42-92. 2011As the major etiological agent of the common cold, human rhinoviruses (HRV) cause millions of lost working and school days annually...
Mega-dose vitamin C in treatment of the common cold: a randomised controlled trialC Audera
National Centre for Epidemiology and Population Health, Australian National University, Canberra, ACT
Med J Aust 175:359-62. 2001OBJECTIVE: To determine the effect of large doses of vitamin C in the treatment of the common cold. STUDY DESIGN: Double-blind, randomised clinical trial with four intervention arms: vitamin C at daily doses of 0...
Variant effect of first- and second-generation antihistamines as clues to their mechanism of action on the sneeze reflex in the common coldP S Muether
Aachen Medical School, Aachen, Germany
Clin Infect Dis 33:1483-8. 2001..The effectiveness of first-generation antihistamines in blocking sneezing in colds may be due primarily to neuropharmacological manipulation of histaminic and muscarinic receptors in the medulla...
Combined antiviral-antimediator treatment for the common coldJack M Gwaltney
Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
J Infect Dis 186:147-54. 2002..IFN-alpha2b added to the effectiveness of chlorpheniramine and ibuprofen and was well tolerated...
Effectiveness of an antihistamine-decongestant combination for young children with the common cold: a randomized, controlled clinical trialN Hutton
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland
J Pediatr 118:125-30. 1991..We conclude that there is no clinically significant improvement in symptoms of upper respiratory tract infection, including no significant placebo effect, in young children for whom an antihistamine-decongestant is prescribed...
Types of stressors that increase susceptibility to the common cold in healthy adultsS Cohen
Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
Health Psychol 17:214-23. 1998..They were then inoculated with common cold viruses and monitored for the onset of disease...
Understanding the symptoms of the common cold and influenzaRon Eccles
Common Cold Centre, Cardiff School of Biosciences, Cardiff School of Biosciences, Cardiff University, Cardiff, UK
Lancet Infect Dis 5:718-25. 2005The common cold and influenza (flu) are the most common syndromes of infection in human beings...
Detection by reverse transcription-polymerase chain reaction of influenza C in nasopharyngeal secretions of adults with a common coldM Hirsilä
Department of Medical Microbiology, University of Oulu, Oulu, Finland
J Infect Dis 183:1269-72. 2001..Two hundred otherwise healthy adults with recent onset of a common cold were studied. Nasopharyngeal aspirates were collected at entry to the study and 1 week later...
Home-based therapies for the common cold among European American and ethnic minority families: the interface between alternative/complementary and folk medicineL M Pachter
Department of Pediatrics, Saint Francis Hospital and Medical Center, Hartford, Conn 06105, USA
Arch Pediatr Adolesc Med 152:1083-8. 1998..Also, there has often been a distinction between alternative/ complementary medical practices used by the general population and those used by members of ethnic minority groups and commonly referred to as folk medicine or ethnomedicine...
Allergic rhinitis and the common cold--high cost to societyJ Hellgren
Department of Otorhinolaryngology, Head and Neck Surgery, Capio Lundby Hospital, Wieselgrensplatsen 2A, Goteborg, Sweden
Allergy 65:776-83. 2010The common cold and allergic rhinitis constitute a global health problem that affects social life, sleep, school and work performance and is likely to impose a substantial economic burden on society because of absence from work and ..
Recent advances in rhinovirus therapeuticsCatherine H Charles
Perlan Therapeutics Inc, 6310 Nancy Ridge Drive, Suite 102, San Diego, CA 92121, USA
Curr Drug Targets Infect Disord 4:331-7. 2004Human rhinoviruses are the major causative agents of the common cold. Because there are greater than 100 viral serotypes, little immunological protection is afforded to humans by prior rhinovirus exposure, which accounts for the high ..
Mechanisms of rhinovirus-induced asthmaNikolaos G Papadopoulos
Allergy Department, Second Paediatric Clinic, University of Athens, Greece
Paediatr Respir Rev 5:255-60. 2004....
Childhood socioeconomic status and host resistance to infectious illness in adulthoodSheldon Cohen
Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
Psychosom Med 66:553-8. 2004....
Airborne dispersal as a novel transmission route of coagulase-negative staphylococci: interaction between coagulase-negative staphylococci and rhinovirus infectionWerner E Bischoff
Section on Infectious Diseases, Wake Forest University School of Medicine, Winston-Salem, North Carolina. 27157-1042, USA
Infect Control Hosp Epidemiol 25:504-11. 2004..aureus carriers. Gowns, gloves, and caps had a protective effect, whereas wearing a mask did not further reduce airborne spread...
Efficacy of organic acids in hand cleansers for prevention of rhinovirus infectionsRonald B Turner
University of Virginia School of Medicine, P O Box 800386, Charlottesville, VA 22908, USA
Antimicrob Agents Chemother 48:2595-8. 2004..These results suggest the feasibility of the prevention of rhinovirus transmission by hand treatments that are virucidal on contact and have activity that persists after application...
Effect of interactions between lower airway bacterial and rhinoviral infection in exacerbations of COPDTom M A Wilkinson
Academic Unit of Respiratory Medicine, St. Bartholomew's and the Royal London School of Medicine, St. Bartholomew's Hospital, London, UK
Chest 129:317-24. 2006....
Viral titers in nasal lining fluid compared to viral titers in nasal washes during experimental rhinovirus infectionJ Owen Hendley
Department of Pediatrics Box 800386, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
J Clin Virol 30:326-8. 2004....
Echinacea purpurea for prevention of experimental rhinovirus coldsSteven J Sperber
Department of Internal Medicine, Hackensack University Medical Center, Hackensack, NJ 07601, USA
Clin Infect Dis 38:1367-71. 2004....
Quantitative and qualitative analysis of rhinovirus infection in bronchial tissuesAnne G Mosser
University of Wisconsin, K4 928 CSC 9988, 600 Highland Avenue, Madison, WI 53792, USA
Am J Respir Crit Care Med 171:645-51. 2005..These results confirm that infection of lower airway tissues is a frequent finding during a cold and further demonstrate a patchy distribution of infected cells, a pattern similar to that reported in upper airway tissues...
The role of rhinovirus in asthma exacerbationsSamuel L Friedlander
Division of Allergy and Immunology, Department of Medicine, University of Wisconsin, Madison, WI 53792, USA
J Allergy Clin Immunol 116:267-73. 2005..Advances in our understanding of this interaction might provide knowledge that could ultimately lead to specific treatment modalities to prevent and/or treat this significant burden of asthma exacerbations...
An evaluation of Echinacea angustifolia in experimental rhinovirus infectionsRonald B Turner
University of Virginia School of Medicine, Charlottesville, VA 22908, USA
N Engl J Med 353:341-8. 2005Echinacea has been widely used as an herbal remedy for the common cold, but efficacy studies have produced conflicting results, and there are a variety of echinacea products on the market with different phytochemical compositions...
Echinacea in the prevention of induced rhinovirus colds: a meta-analysisRoland Schoop
A Vogel Bioforce AG, Roggwil, Switzerland
Clin Ther 28:174-83. 2006..Experimental infection studies allow for the standardization of time to initiation of treatment, virus type and dose, and immune competence of volunteers...
Relationship of pleconaril susceptibility and clinical outcomes in treatment of common colds caused by rhinovirusesDaniel C Pevear
ViroPharma Incorporated, Exton, Pennsylvania 19341, USA
Antimicrob Agents Chemother 49:4492-9. 2005..7% of drug-treated subjects, respectively. These patients shed low levels of virus and had no unusual clinical outcomes. Nevertheless, studies on the biologic properties and transmissibility of these variant viruses are warranted...
A case-control study of acute respiratory tract infection in general practice patients in The NetherlandsArianne B van Gageldonk-Lafeber
Department of Infectious Diseases Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
Clin Infect Dis 41:490-7. 2005..Of bacterial infections, only group A beta-hemolytic streptococci were more common in case patients than in control subjects. Furthermore, we demonstrated that asymptomatic persons might be a neglected source of transmission...
Rhinovirus viremia in children with respiratory infectionsMaria Xatzipsalti
Allergy Department, Second Pediatric Clinic, University of Athens, Athens, Greece
Am J Respir Crit Care Med 172:1037-40. 2005..4%): 7 of 28 children with asthma exacerbations (25.0%), 2 of 26 with common cold (7.7%), 1 of 25 with bronchiolitis (4.0%), and 0 of 9 with pneumonia (0%)...
18th International Conference on Antiviral Research. Respiratory virusesAlexandra Kibble
Thomson Scientific, Middlesex House, 34-42 Cleveland Street, London W1T 4JE, UK
IDrugs 8:465-6. 2005
Analysis of tracheal secretions for rhinovirus during natural coldsElinor Simons
Department of Pediatrics, The University of Wisconsin Madison, WI, USA
Pediatr Allergy Immunol 16:276-8. 2005..In addition, these findings suggest that children with tracheostomies carry subclinical viral infections in their tracheas, rather than their noses...
Echinacea angustifolia in rhinovirus infectionsMatthew Leach
N Engl J Med 353:1971-2; author reply 1971-2. 2005
Heated, humidified air for the common coldM Singh
Post Graduate Institute of Medical Education and Research, Pediatrics, Advanced Pediatrics Centre, Sector 12, Chandigarh, India 160012
Cochrane Database Syst Rev 3:CD001728. 2006Heated, humidified air has long been used by common cold sufferers. The theoretical basis is that steam may help congested mucus drain better and heat may destroy cold virus as it does in vitro.
Non-antibiotic treatments for upper-respiratory tract infections (common cold)B Arroll
Department of General Practice and Primary Health Care, University of Auckland, Private Bag 92019, Auckland, New Zealand
Respir Med 99:1477-84. 2005To review the seven Cochrane reviews of non-antibiotic treatment for the common cold.
Echinacea angustifolia in rhinovirus infectionsMark Blumenthal
N Engl J Med 353:1971-2; author reply 1971-2. 2005
Virucidal hand treatments for prevention of rhinovirus infectionRonald B Turner
Department of Pediatrics, University of Virginia School of Medicine, PO Box 800386, Charlottesville, VA 22908, USA
J Antimicrob Chemother 56:805-7. 2005Rhinovirus infections are associated with substantial morbidity and economic cost. The available common cold remedies are of limited utility and specific antiviral approaches have been unsuccessful...
How viral infections cause exacerbation of airway diseasesPatrick Mallia
Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, Norfolk Pl, London W2 1PG, UK
Chest 130:1203-10. 2006..In addition, such studies can identify new therapeutic targets for the development of novel drugs for the prevention and treatment of exacerbations...
Upper airway viral infectionsDavid Proud
Airway Inflammation Group and Institute of Infection, Immunity and Inflammation, University of Calgary, Alberta, Canada
Pulm Pharmacol Ther 21:468-73. 2008..We will also consider current and potential therapeutic approaches for the treatment of URI and their lower airway complications...
Acute cooling of the body surface and the common coldR Eccles
Common Cold Centre, Cardiff School of Biosciences, Cardiff University, United Kingdom
Rhinology 40:109-14. 2002..infections are the result of a "chill" and that the onset of a respiratory infection such as the common cold is often associated with acute cooling of the body surface, especially as the result of wet clothes and hair...
Rhinovirus infection in nonasthmatic subjects: effects on intrapulmonary airwaysJ de Kluijver
Dept of Pulmonology, Leiden University Medical Center, The Netherlands
Eur Respir J 20:274-9. 2002The common cold is a highly prevalent, uncomplicated upper airway disease. However, rhinovirus (RV) infection can lead to exacerbation of asthma, with worsening in airway hyperresponsiveness and bronchial inflammation...
[The role of respiratory infections in chronic obstructive pulmonary disease]Gernot Rohde
Medizinische Klinik III Pneumologie, Allergologie, Schlaf und Beatmungsmedizin, Berufsgenossenschaftliche Kliniken Bergmannsheil Klinikum der Ruhr Universität Bochum, Burkle de la Camp Platz 1, 44789, Bochum, Germany
Med Klin (Munich) 102:893-8. 2007..This knowledge might offer new therapeutic perspectives in the future. The aim of this review is, therefore, to describe the inflammatory processes involved and to specify the role of respiratory infections in this context...
Acute upper airway infectionsJ V West
Children's Services, Leicestershire and Rutland Healthcare Trust, Leicester, UK
Br Med Bull 61:215-30. 2002..Numerous therapies for the common cold have no effect on symptoms or outcome...
Respiratory viral infections in adultsStephen B Greenberg
Department of Medicine, Baylor College of Medicine, Medicine Service, Ben Taub General Hospital, Houston, Texas 77030, USA
Curr Opin Pulm Med 8:201-8. 2002..The inactivated influenza vaccine has been shown to benefit healthy adults and to be safe in asthmatic adults and children...
Rhinovirus respiratory infections and asthmaJames E Gern
Department of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin 53792-9988, USA
Am J Med 112:19S-27S. 2002..The precise direct and indirect mechanisms of viral contribution to exacerbations must still be elucidated. Understanding them will have an impact on the design of future treatment modalities...
Epidemiology of viral respiratory infectionsArnold S Monto
Department of Epidemiology, School of Public Health, University of Michigan at Ann Arbor, Ann Arbor, Michigan, USA
Am J Med 112:4S-12S. 2002....
Virological and serological analysis of rhinovirus infections during the first two years of life in a cohort of childrenS Blomqvist
Department of Virology, National Public Health Institute, Helsinki, Finland
J Med Virol 66:263-8. 2002..Of 458 acute otitis media episodes studied, 41% were shown to be associated with a rhinovirus by RT-PCR-hybridization, while significant fourfold rise in rhinoviral antibodies was detected only in 7% of the cases...
Pulmonary imaging and function in the common coldT Puhakka
Department of Pediatrics, Turku University Hospital, Finland
Scand J Infect Dis 33:211-4. 2001The common cold is generally considered to be an upper respiratory tract infection. We studied the lower respiratory tract in 76 otherwise healthy young adults with the common cold...
Understanding the mechanisms of viral induced asthma: new therapeutic directionsNicole G Hansbro
Priority Research Centre for Asthma and Respiratory Disease, Faculty of Health, The University of Newcastle, New South Wales 2308, Australia
Pharmacol Ther 117:313-53. 2008..This research has led to many potential therapeutic strategies and, although none are yet part of clinical practise, they show much promise for the prevention and treatment of viral disease and subsequent asthma...
Epidermal growth factor receptor signaling to Erk1/2 and STATs control the intensity of the epithelial inflammatory responses to rhinovirus infectionKenneth Liu
Departments of Pharmacology and Medicine, University of Melbourne, Melbourne, Victoria 3010, Australia
J Biol Chem 283:9977-85. 2008..These results suggest that targeting EGFR may provide a selective therapy that dampens neutrophil-driven inflammation without compromising essential antiviral pathways mediated by pathogen recognition receptors such as TLR3...
Dispersal of Staphylococcus aureus into the air associated with a rhinovirus infectionStefano Bassetti
Section on Infectious Diseases, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA
Infect Control Hosp Epidemiol 26:196-203. 2005..Wearing barrier garb but not a mask decreased dispersal of S. aureus into the air (P < .05). CONCLUSION: Virus-induced dispersal of S. aureus into the air may have an important role in the transmission of S. aureus and other bacteria...
Iota-Carrageenan is a potent inhibitor of rhinovirus infectionAndreas Grassauer
Marinomed Biotechnologie GmbH, Veterinaerplatz 1 HA, A 1210 Vienna, Austria
Virol J 5:107. 2008Human rhinoviruses (HRVs) are the predominant cause of common cold. In addition, HRVs are implicated in the worsening of COPD and asthma, as well as the loss of lung transplants...
[Virological surveillance of acute respiratory tract illnesses of children in Morioka, Japan. II. Rhinovirus infection]I Matsumoto
Department of Bacteriology, School of Medicine, Iwate Medical University
Kansenshogaku Zasshi 65:1286-96. 1991..Viral dual infections were detected in total 20 cases included 12 HRV-associated cases. In no case was the illness of greater severity than might have been caused by either agent acting singly...
Research Grants
- MOLECULAR BIOLOGY OF POLIOVIRUS RNA REPLICATIONJAMES FLANEGAN; Fiscal Year: 2007..with these viruses include paralytic poliomyelitis, meningitis, encephalitis, myocarditis, hepatitis and the common cold. Post-polio syndrome is also an important clinical manifestation that occurs in patients 30-40 years after the ..
- Mechanisms of viral proteases in coronavirus replication and pathogenesisAndrew D Mesecar; Fiscal Year: 2010..positive strand RNA viruses which cause a range of illness, from relatively mild respiratory disease (croup and common cold like symptoms due to HCoV- NL63, 229e or OC43) to severe acute respiratory syndrome (SARS) outbreaks in humans...
- Control of cap-independent translation by a viral 3' UTRWYATT MILLER; Fiscal Year: 2009..research may contribute to understanding mechanisms by which medically important viruses such as poliovirus, common cold rhinoviruses, the SARS virus, dengue virus, and West Nile viruses regulate gene expression and replication...
- Control of cap-independent translation by a viral 3' UTRWYATT MILLER; Fiscal Year: 2009..research may contribute to understanding mechanisms by which medically important viruses such as poliovirus, common cold rhinoviruses, the SARS virus, dengue virus, and West Nile viruses regulate gene expression and replication...
- MOLECULAR BIOLOGY OF POLIOVIRUS RNA REPLICATIONJames Bert Flanegan; Fiscal Year: 2010..with these viruses include paralytic poliomyelitis, meningitis, encephalitis, myocarditis, hepatitis and the common cold. Post-polio syndrome is also an important clinical manisfestation that occurrs in patients 30-40 years after ..
- MOLECULAR BIOLOGY OF POLIOVIRUS RNA REPLICATIONJAMES FLANEGAN; Fiscal Year: 2009..with these viruses include paralytic poliomyelitis, meningitis, encephalitis, myocarditis, hepatitis and the common cold. Post-polio syndrome is also an important clinical manisfestation that occurrs in patients 30-40 years after ..
- MOLECULAR BIOLOGY OF POLIOVIRUS RNA REPLICATIONJAMES FLANEGAN; Fiscal Year: 2006..associated with these viruses include poliomyelitis, meningitis, encephalitis, myocarditis, hepatitis and the common cold. Other positive-strand RNA viruses that form a large group of important human pathogens include hepatitis C ..
- Control of cap-independent translation by a viral 3' UTRWYATT ALLEN MILLER; Fiscal Year: 2010..research may contribute to understanding mechanisms by which medically important viruses such as poliovirus, common cold rhinoviruses, the SARS virus, dengue virus, and West Nile viruses regulate gene expression and replication...
- Innovative Tools for In Vivo Computational Prediction of Lumbar StressesRichard Komistek; Fiscal Year: 2009..medical problem in the United States, and the second most common reason for doctor visits behind the common cold. Lower back pain is the leading cause of disability among people ages 19-45 and is the leading cause of missed ..
- Innovative Tools for In Vivo Computational Prediction of Lumbar StressesRichard Komistek; Fiscal Year: 2007..medical problem in the United States, and the second most common reason for doctor visits behind the common cold. Lower back pain is the leading cause of disability among people ages 19-45 and is the leading cause of missed ..
- Innovative Tools for In Vivo Computational Prediction of Lumbar StressesRICHARD DAVID KOMISTEK; Fiscal Year: 2010..medical problem in the United States, and the second most common reason for doctor visits behind the common cold. Lower back pain is the leading cause of disability among people ages 19-45 and is the leading cause of missed ..
- Innate Immunity in Otitis Media PathogenesisDavid J Lim; Fiscal Year: 2010Following the common cold, otitis media (OM), or inflammation of the middle ear, is the most frequent illness resulting in visits to physicians and the most common cause of hearing impairment and dizziness in children...
- Innate Immunity in Otitis Media PathogenesisDavid Lim; Fiscal Year: 2009Following the common cold, otitis media (OM), or inflammation of the middle ear, is the most frequent illness resulting in visits to physicians and the most common cause of hearing impairment and dizziness in children...
- PROTEIN STABILITY IN HUMAN RHINOVIRUSCAROL POST; Fiscal Year: 2005..HRV is a member of the picornavirus family and the leading causative agent for the common cold. Other important human pathogens among the members of the picornaviruses are poliovirus, coxsackie virus and ..
- EXPRESSION OF FUNCTIONAL POLIOVIRUS REPLICATION GENESCASEY MORROW; Fiscal Year: 1991..This large group of medically important viruses includes agents of the common cold, infectious hepatitis and encephalomyocarditis...
- CORONAVIRUS-RECEPTOR INTERACTIONSKathryn Holmes; Fiscal Year: 2003..viruses that cause most common colds, such combination drugs would make it unnecessary to identify the type of common cold virus causing early symptoms before initiating therapy...
- A Simulator for Sound Production in AirwaysIngo Titze; Fiscal Year: 2007..g. snoring, pediatric strider, croup, and several symptoms of influenza and the common cold)...
- A Simulator for Sound Production in AirwaysIngo Titze; Fiscal Year: 2009..g. snoring, pediatric strider, croup, and several symptoms of influenza and the common cold)...
- A Simulator for Sound Production in AirwaysIngo R Titze; Fiscal Year: 2010..g. snoring, pediatric strider, croup, and several symptoms of influenza and the common cold)...
- PICORNAVIRUS MOLECULAR BIOLOGYEckard Wimmer; Fiscal Year: 2010..These infections lead to a variety of diseases ranging from the mild (common cold) to the serious (poliomyelitis)...
- A NETWORK OF RESEARCH UNITS TO STUDY CLINICAL WOUND CAREJames Quinn; Fiscal Year: 2004DESCRIPTION (Taken from the applicants abstract): Next to the common cold, traumatic wounds are the most common reasons people seek medical care in the United States. An estimated 3...
- TRANSLATION-INHIBITION OF HEPATITIS C AND POLIO VIRUSESAsim Dasgupta; Fiscal Year: 2003..A) and chronic hepatitis (hepatitis C), common cold (rhinovirus), and myocarditis and encephalitis (coxsackie) among others...
- Phosphine-Catalyzed Annulations and Their ApplicationsOhyun Kwon; Fiscal Year: 2007..The targets chosen are highly relevant to national public health, specifically the treatment of the common cold, hypertension, amoebic dysentery, malaria, arrhythmia, and cancer...
- Phosphine-Catalyzed Annulations and Their ApplicationsOhyun Kwon; Fiscal Year: 2010..The targets chosen are highly relevant to national public health, specifically the treatment of the common cold, hypertension, amoebic dysentery, malaria, arrhythmia, and cancer...
