common cold

Summary

Summary: A catarrhal disorder of the upper respiratory tract, which may be viral, a mixed infection, or an allergic reaction. It is marked by acute coryza, slight rise in temperature, chilly sensations, and general indisposition. (Dorland, 27th ed)

Top Publications

  1. ncbi Duration and severity of symptoms and levels of plasma interleukin-1 receptor antagonist, soluble tumor necrosis factor receptor, and adhesion molecules in patients with common cold treated with zinc acetate
    Ananda S Prasad
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Infect Dis 197:795-802. 2008
  2. ncbi Social ties and susceptibility to the common cold
    S Cohen
    Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    JAMA 277:1940-4. 1997
  3. ncbi The common cold
    Terho Heikkinen
    Department of Paediatrics, Turku University Hospital, Turku, Finland
    Lancet 361:51-9. 2003
  4. pmc Perception of empathy in the therapeutic encounter: effects on the common cold
    David Rakel
    Department of Family Medicine, University of Wisconsin Madison, Madison, WI, USA
    Patient Educ Couns 85:390-7. 2011
  5. ncbi Treatment of the common cold
    Madeline Simasek
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am Fam Physician 75:515-20. 2007
  6. ncbi Understanding the symptoms of the common cold and influenza
    Ron Eccles
    Common Cold Centre, Cardiff School of Biosciences, Cardiff School of Biosciences, Cardiff University, Cardiff, UK
    Lancet Infect Dis 5:718-25. 2005
  7. ncbi Vitamin C for preventing and treating the common cold
    Harri Hemilä
    Department of Public Health, POB 41, University of Helsinki, Helsinki, Finland
    Cochrane Database Syst Rev 1:CD000980. 2013
  8. ncbi Antibiotic prescribing for adults with colds, upper respiratory tract infections, and bronchitis by ambulatory care physicians
    R Gonzales
    Division of General Internal Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    JAMA 278:901-4. 1997
  9. ncbi Knowledge and beliefs of primary care physicians, pharmacists, and parents on antibiotic use for the pediatric common cold
    Hong Jun Cho
    Department of Family Medicine, University of Ulsan College of Medicine, Songpa P O Box 145, Seoul 138 736, South Korea
    Soc Sci Med 58:623-9. 2004
  10. pmc Consumer attitudes and use of antibiotics
    Jodi Vanden Eng
    Connecticut Emerging Infections Program, New Haven 06510, USA
    Emerg Infect Dis 9:1128-35. 2003

Detail Information

Publications252 found, 100 shown here

  1. ncbi Duration and severity of symptoms and levels of plasma interleukin-1 receptor antagonist, soluble tumor necrosis factor receptor, and adhesion molecules in patients with common cold treated with zinc acetate
    Ananda S Prasad
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Infect Dis 197:795-802. 2008
    Zinc lozenges have been used for treatment of the common cold; however, the results remain controversial.
  2. ncbi Social ties and susceptibility to the common cold
    S Cohen
    Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    JAMA 277:1940-4. 1997
    ..To examine the hypothesis that diverse ties to friends, family, work, and community are associated with increased host resistance to infection...
  3. ncbi The common cold
    Terho Heikkinen
    Department of Paediatrics, Turku University Hospital, Turku, Finland
    Lancet 361:51-9. 2003
    Despite great advances in medicine, the common cold continues to be a great burden on society in terms of human suffering and economic losses. Of the several viruses that cause the disease, the role of rhinoviruses is most prominent...
  4. pmc Perception of empathy in the therapeutic encounter: effects on the common cold
    David Rakel
    Department of Family Medicine, University of Wisconsin Madison, Madison, WI, USA
    Patient Educ Couns 85:390-7. 2011
    To evaluate the effects of patient-practitioner interaction on the severity and duration of the common cold.
  5. ncbi Treatment of the common cold
    Madeline Simasek
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am Fam Physician 75:515-20. 2007
    The common cold is a viral illness that affects persons of all ages, prompting frequent use of over-the-counter and prescription medications and alternative remedies. Treatment focuses on relieving symptoms (e.g...
  6. ncbi Understanding the symptoms of the common cold and influenza
    Ron Eccles
    Common Cold Centre, Cardiff School of Biosciences, Cardiff School of Biosciences, Cardiff University, Cardiff, UK
    Lancet Infect Dis 5:718-25. 2005
    The common cold and influenza (flu) are the most common syndromes of infection in human beings...
  7. ncbi Vitamin C for preventing and treating the common cold
    Harri Hemilä
    Department of Public Health, POB 41, University of Helsinki, Helsinki, Finland
    Cochrane Database Syst Rev 1:CD000980. 2013
    Vitamin C (ascorbic acid) for preventing and treating the common cold has been a subject of controversy for 70 years.
  8. ncbi Antibiotic prescribing for adults with colds, upper respiratory tract infections, and bronchitis by ambulatory care physicians
    R Gonzales
    Division of General Internal Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    JAMA 278:901-4. 1997
    ..How frequently antibiotics are prescribed for these conditions and for and by whom is not known...
  9. ncbi Knowledge and beliefs of primary care physicians, pharmacists, and parents on antibiotic use for the pediatric common cold
    Hong Jun Cho
    Department of Family Medicine, University of Ulsan College of Medicine, Songpa P O Box 145, Seoul 138 736, South Korea
    Soc Sci Med 58:623-9. 2004
    ..practitioners and pediatricians), pharmacists, and parents regarding the use of antibiotics for the pediatric common cold, using a self-administered questionnaire for physicians and pharmacists and a telephone interview for parents...
  10. pmc Consumer attitudes and use of antibiotics
    Jodi Vanden Eng
    Connecticut Emerging Infections Program, New Haven 06510, USA
    Emerg Infect Dis 9:1128-35. 2003
    ..National educational efforts are needed to address these issues if patient demand for antibiotics is to be reduced...
  11. ncbi Epidemiological relationships between the common cold and exacerbation frequency in COPD
    J R Hurst
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, Hampstead, London, NW3 2QG, UK
    Eur Respir J 26:846-52. 2005
    ..Exacerbation frequency in chronic obstructive pulmonary disease is associated with an increased frequency of acquiring the common cold, rather than an increased propensity to exacerbation once a cold has been acquired.
  12. pmc Practitioner empathy and the duration of the common cold
    David P Rakel
    School of Medicine and Public Health, University of Wisconsin, Madison, WI 53715, USA
    Fam Med 41:494-501. 2009
    This study's objective was to assess the relationship of empathy in medical office visits to subsequent outcomes of the common cold.
  13. pmc Viruses and bacteria in the etiology of the common cold
    M J Mäkelä
    Department of Pediatrics, University of Turku, Finland
    J Clin Microbiol 36:539-42. 1998
    ..The results show that although approximately 50% of episodes of the common cold were caused by rhinoviruses, the etiology can vary depending on the epidemiological situation with regard to ..
  14. ncbi Rhinovirus-induced airway inflammation in asthma: effect of treatment with inhaled corticosteroids before and during experimental infection
    K Grunberg
    Department of Pulmonology, Department of Medical Decision Making, Leiden University Medical Center LUMC, Leiden, The Netherlands
    Am J Respir Crit Care Med 164:1816-22. 2001
    ..The latter finding is in keeping with the limited protection of inhaled corticosteroids against acute asthma exacerbations...
  15. ncbi Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study
    Jonathan M Corne
    University Medicine, Southampton General Hospital, Southampton, UK
    Lancet 359:831-4. 2002
    ..Rhinovirus infections cause exacerbations of asthma. We postulated that people with asthma are more susceptible to rhinovirus infection than people without the disease and compared the susceptibility of these groups...
  16. pmc Complementary and alternative medicine for prevention and treatment of the common cold
    Richard Nahas
    Seekers Centre for Integrative Medicine, Ottawa, ON
    Can Fam Physician 57:31-6. 2011
    To review the evidence supporting complementary and alternative medicine approaches to treatment and prevention of the common cold in adults.
  17. pmc Echinacea for treating the common cold: a randomized trial
    Bruce Barrett
    Department of Family Medicine, University of Wisconsin, Madison, Wisconsin 53715, USA
    Ann Intern Med 153:769-77. 2010
    Echinacea is widely used to treat the common cold.
  18. ncbi Mega-dose vitamin C in treatment of the common cold: a randomised controlled trial
    C Audera
    National Centre for Epidemiology and Population Health, Australian National University, Canberra, ACT
    Med J Aust 175:359-62. 2001
    OBJECTIVE: To determine the effect of large doses of vitamin C in the treatment of the common cold. STUDY DESIGN: Double-blind, randomised clinical trial with four intervention arms: vitamin C at daily doses of 0...
  19. pmc Reduction of common cold symptoms by encapsulated juice powder concentrate of fruits and vegetables: a randomised, double-blind, placebo-controlled trial
    Stephanie Roll
    Institute for Social Medicine, Epidemiology and Health Economics, Charité University Medical Centre, Luisenstrasse 57, 10098 Berlin, Germany
    Br J Nutr 105:118-22. 2011
    Dietary supplements have been suggested in the prevention of the common cold, but previous investigations have been inconsistent...
  20. ncbi Probiotic bacteria reduced duration and severity but not the incidence of common cold episodes in a double blind, randomized, controlled trial
    Michael de Vrese
    Institute of Physiology and Biochemistry of Nutrition, Federal Research Centre of Nutrition and Food, Hermann Weigmann Strasse 1, D 24103 Kiel, Germany
    Vaccine 24:6670-4. 2006
    To investigate the effect of long-term consumption of probiotic bacteria on viral respiratory tract infections (common cold, influenza), a randomized, double blind, controlled intervention study was performed during two winter/spring ..
  21. ncbi Dynamics of human respiratory virus-specific CD8+ T cell responses in blood and airways during episodes of common cold
    Jojanneke Heidema
    Division of Paediatrics, Wilhelmina Children s Hospital, Utrecht, The Netherlands
    J Immunol 181:5551-9. 2008
    ..Taken together, these results showed a significant systemic T cell response during relatively mild secondary infections and extensive dynamics of virus-specific and nonspecific Ag-experienced T cells...
  22. ncbi Relations among questionnaire and laboratory measures of rhinovirus infection
    B Barrett
    University of Wisconsin Medical School, 777 S Mills, Madison, WI 53715, USA
    Eur Respir J 28:358-63. 2006
    ..The inclusion of functional and quality-of-life items in the Wisconsin Upper Respiratory Symptom Survey does not significantly decrease the strength of association with laboratory-assessed biomarkers...
  23. ncbi Misconceptions about colds and predictors of health service utilization
    Grace M Lee
    Division of Infectious Diseases, Children s Hospital, Boston, Massachusetts 02115, USA
    Pediatrics 111:231-6. 2003
    ..The objective of this study was to determine predictors of reported ED use and ambulatory care use for colds among families with young children...
  24. ncbi Rhinovirus infection increases 5-lipoxygenase and cyclooxygenase-2 in bronchial biopsy specimens from nonatopic subjects
    Michelle L Seymour
    Division of Respiratory Cell and Molecular Biology, University of Southampton School of Medicine, Southampton, United Kingdom
    J Infect Dis 185:540-4. 2002
    ..13). Cold symptom scores correlated with bronchial immunostaining for FLAP (rho = 0.93; P =.001). In normal subjects, rhinovirus colds induce bronchial inflammation with markedly enhanced expression of 5-LO pathway proteins and COX-2...
  25. pmc Nasal inflammation induced by a common cold: comparison between controls and patients with nasal polyposis under topical steroid therapy
    C Dassonville
    Laboratory of Public Health and Environment, Faculty of Pharmacy, University Paris V, Paris
    Acta Otorhinolaryngol Ital 27:78-82. 2007
    The evolution of nasal inflammation during a common cold in patients with nasal polyposis under topical steroid treatment is not clearly defined in the literature...
  26. ncbi Inflammatory changes during the 'common cold' are associated with platelet activation and increased reactivity of platelets to agonists
    Rolf P Kreutz
    Sinai Center for Thrombosis Research, Baltimore, Maryland 21215, USA
    Blood Coagul Fibrinolysis 18:713-8. 2007
    ..We hypothesized that changes in platelet activation and reactivity and inflammation occur during the 'common cold'. Previously healthy individuals with viral upper respiratory tract infections were studied (n = 18)...
  27. ncbi Influence of attendance at day care on the common cold from birth through 13 years of age
    Thomas M Ball
    Department of Pediatrics, University of Arizona College of Medicine, 1501 N Campbell Ave, PO Box 245073, Tucson, AZ 85724 5073, USA
    Arch Pediatr Adolesc Med 156:121-6. 2002
    To describe trends in the occurrence of the common cold during the first 13 years of life among children who attended different childcare settings early in life.
  28. ncbi Transmission of viral respiratory infections in the home
    D A Goldmann
    Department of Medicine Children s Hospital, Boston, MA 02115, USA
    Pediatr Infect Dis J 19:S97-102. 2000
    ..study, from the plains of Salisbury, to the hills of Virginia, to the collegiate environment of Madison, WI, the precise routes rhinovirus takes to inflict the misery of the common cold on a susceptible population remain controversial.
  29. pmc Weekly monitoring of children with asthma for infections and illness during common cold seasons
    Jaime P Olenec
    Department of Pediatrics, University of Wisconsin, Madison, WI 53792 4108, USA
    J Allergy Clin Immunol 125:1001-1006.e1. 2010
    ..Exacerbations of childhood asthma and rhinovirus infections both peak during the spring and fall, suggesting that viral infections are major contributors to seasonal asthma morbidity...
  30. ncbi The treatment of rhinovirus infections: progress and potential
    R B Turner
    Department of Pediatrics, Medical University of South Carolina, Clinical Sciences Building, Room 312, 171 Ashley Avenue, Charleston, SC 29425, USA
    Antiviral Res 49:1-14. 2001
    The common cold is an important illness both as a result of the economic impact of this common disease and because of the morbidity associated with the complications of the illness...
  31. pmc Iota-Carrageenan is a potent inhibitor of rhinovirus infection
    Andreas Grassauer
    Marinomed Biotechnologie GmbH, Veterinaerplatz 1 HA, A 1210 Vienna, Austria
    Virol J 5:107. 2008
    Human rhinoviruses (HRVs) are the predominant cause of common cold. In addition, HRVs are implicated in the worsening of COPD and asthma, as well as the loss of lung transplants...
  32. pmc Vitamin E and respiratory tract infections in elderly nursing home residents: a randomized controlled trial
    Simin Nikbin Meydani
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Mass 02111, USA
    JAMA 292:828-36. 2004
    ..Vitamin E supplementation has been shown to improve immune response in elderly persons. However, the clinical importance of these findings has not been determined...
  33. ncbi Psychological stress and susceptibility to the common cold
    S Cohen
    Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213
    N Engl J Med 325:606-12. 1991
    ..To investigate this issue, we prospectively studied the relation between psychological stress and the frequency of documented clinical colds among subjects intentionally exposed to respiratory viruses...
  34. ncbi Effect of Lactobacillus gasseri PA 16/8, Bifidobacterium longum SP 07/3, B. bifidum MF 20/5 on common cold episodes: a double blind, randomized, controlled trial
    Michael de Vrese
    Institute for Physiology and Biochemistry of Nutrition, Federal Research Centre of Nutrition and Food, Hermann Weigmann Strasse 1, D 24103 Kiel, Germany
    Clin Nutr 24:481-91. 2005
    ..bifidum MF 20/5 (5 x 10(7) cfu/tablet) during at least 3 months influences the severity of symptoms and the incidence and duration of the common cold.
  35. ncbi Rhinovirus infections: more than a common cold
    Marc B Hershenson
    Am J Respir Crit Care Med 174:1284-5. 2006
  36. ncbi Symptom severity patterns in experimental common colds and their usefulness in timing onset of illness in natural colds
    Jack M Gwaltney
    Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville 22908, USA
    Clin Infect Dis 36:714-23. 2003
    ..5% of natural colds on day 1 of illness. Histories given by compensated patients in natural cold treatment trials are inaccurate...
  37. ncbi A multicultural approach to the patient who has a common cold
    William F Pfeiffer
    Pediatric Department, Kaiser Permanente Honolulu Clinic, Honolulu, Hawaii, USA
    Pediatr Rev 26:170-5. 2005
  38. ncbi Rhinovirus transmission within families with children: incidence of symptomatic and asymptomatic infections
    Ville Peltola
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    J Infect Dis 197:382-9. 2008
    ..Rhinoviruses are the most common cause of respiratory tract infections, but the transmission in families has not been studied using sensitive and specific molecular detection methods...
  39. ncbi Cytokine responses in the common cold and otitis media
    Todd M Wine
    Division of Pediatric Otolaryngology, Children s Hospital of Pittsburgh of UPMC, Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Curr Allergy Asthma Rep 12:574-81. 2012
    ..The common cold and otitis media are two such disease states, and much has been learned about the various effects of cytokines ..
  40. ncbi Allergic rhinitis and the common cold--high cost to society
    J Hellgren
    Department of Otorhinolaryngology, Head and Neck Surgery, Capio Lundby Hospital, Wieselgrensplatsen 2A, Goteborg, Sweden
    Allergy 65:776-83. 2010
    The common cold and allergic rhinitis constitute a global health problem that affects social life, sleep, school and work performance and is likely to impose a substantial economic burden on society because of absence from work and ..
  41. ncbi Patient beliefs about the characteristics, causes, and care of the common cold: an update
    B L Braun
    Health Research Center, Institute for Research and Education, HealthSystem Minnesota, Minneapolis 55416, USA
    J Fam Pract 49:153-6. 2000
    ..Many people seek medical care for cold symptoms. The cold-related knowledge and beliefs of adults seeking medical care for themselves or their children may not correspond with current medical opinion...
  42. ncbi Use of surgical face masks to reduce the incidence of the common cold among health care workers in Japan: a randomized controlled trial
    Joshua L Jacobs
    University of Hawaii John A Burns School of Medicine, Honolulu, HI, USA
    Am J Infect Control 37:417-9. 2009
    ..Health care workers outside surgical suites in Asia use surgical-type face masks commonly. Prevention of upper respiratory infection is one reason given, although evidence of effectiveness is lacking...
  43. pmc Validity of the common cold questionnaire (CCQ) in asthma exacerbations
    Heather Powell
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, New Lambton, New South Wales, Australia
    PLoS ONE 3:e1802. 2008
    The common cold questionnaire (CCQ) is used to discriminate those with and without a viral infection. Its usefulness in people with acute asthma is unknown...
  44. ncbi Combined antiviral-antimediator treatment for the common cold
    Jack M Gwaltney
    Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Infect Dis 186:147-54. 2002
    ..IFN-alpha2b added to the effectiveness of chlorpheniramine and ibuprofen and was well tolerated...
  45. ncbi Antibiotics for the common cold and acute purulent rhinitis
    Tim Kenealy
    Department of General Practice and Primary Health Care, University of Auckland, Auckland, New Zealand
    Cochrane Database Syst Rev 6:CD000247. 2013
    ..It has long been believed that antibiotics have no role in the treatment of common colds yet they are often prescribed in the belief that they may prevent secondary bacterial infections...
  46. ncbi Effect of vitamin C on common cold: randomized controlled trial
    S Sasazuki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Chuo Ku, Tokyo, Japan
    Eur J Clin Nutr 60:9-17. 2006
    To investigate the relationship between the common cold and vitamin C supplementation.
  47. ncbi Testing of cough reflex sensitivity in children suffering from allergic rhinitis and common cold
    J Plevkova
    Department of Pathophysiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia
    J Physiol Pharmacol 57:289-96. 2006
    ..Cough also is enhanced by acute inflammation in the upper airways in nonatopic children...
  48. ncbi Effects of intranasal xylometazoline, alone or in combination with ipratropium, in patients with common cold
    Ronald Eccles
    Common Cold Centre and Healthcare Clinical Trials, Cardiff School of Biosciences, Cardiff University, Cardiff, UK
    Curr Med Res Opin 26:889-99. 2010
    b>Common cold is one of the most prevalent conditions that family doctors encounter...
  49. ncbi Rhinoviruses: important respiratory pathogens
    A Pitkaranta
    Department of Otorhinolaryngology, Helsinki University Central Hospital, Finland
    Ann Med 30:529-37. 1998
    ..However, the high incidence of HRV infections and their frequent association with upper and lower respiratory tract complications highlight the need for more effective means of prevention and treatment...
  50. ncbi Visiting a sauna: does inhaling hot dry air reduce common cold symptoms? A randomised controlled trial
    Daniel Pach
    Institute for Social Medicine, Epidemiology and Health Economics, Charite University Medical Center, Berlin, Germany
    Med J Aust 193:730-4. 2010
    To compare the efficacy of applying hot dry air versus dry air at room temperature to the throat of patients with a newly acquired common cold using a symptom severity score.
  51. ncbi [Common cold--risk factors, transmission and treatment]
    H Herløv-Nielsen
    H S Rigshospitalet, Finsencentret, epidemiklinikken
    Ugeskr Laeger 163:5643-6. 2001
    The common cold is the most prevalent disease in humans. It is generally caused by rhinovirus. Bacterial involvement is rare, and an uncomplicated common cold does not require treatment with antibiotics...
  52. ncbi [Common cold]
    J Padberg
    HELIOS Klinikum Emil von Behring, Zentrum für Pneumologie und Thoraxchirurgie Heckeshorn
    Dtsch Med Wochenschr 131:2341-9; quiz 2351-2. 2006
  53. ncbi The effects of a hot drink on nasal airflow and symptoms of common cold and flu
    A Sanu
    Common Cold Centre and Healthcare Clinical Trials, Cardiff School of Biosciences, Cardiff University, Cardiff, United Kingdom
    Rhinology 46:271-5. 2008
    Hot drinks are a common treatment for common cold and flu but there are no studies reported in the scientific and clinical literature on this mode of treatment...
  54. pmc Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers
    Frederick G Hayden
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Antimicrob Agents Chemother 47:3907-16. 2003
    ..Results from these studies in experimental rhinoviral infection support continued investigation of intranasal ruprintrivir in the setting of natural HRV infection...
  55. ncbi Role of nasopharyngeal culture in antibiotic prescription for patients with common cold or acute sinusitis
    L Kaiser
    Division of Infectious Diseases, University Hospital of Geneva, Switzerland
    Eur J Clin Microbiol Infect Dis 20:445-51. 2001
    ..Adults with a clinical diagnosis of acute sinusitis or common cold were enrolled...
  56. ncbi Acute cooling of the feet and the onset of common cold symptoms
    Claire Johnson
    Common Cold Centre, Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, UK
    Fam Pract 22:608-13. 2005
    There is a common folklore that chilling of the body surface causes the development of common cold symptoms, but previous clinical research has failed to demonstrate any effect of cold exposure on susceptibility to infection with common ..
  57. pmc Complementary treatment of the common cold and flu with medicinal plants--results from two samples of pharmacy customers in Estonia
    Ain Raal
    Department of Pharmacy, University of Tartu, Tartu, Estonia
    PLoS ONE 8:e58642. 2013
    The aim of the current survey was to investigate the complementary self-treatment of the common cold and flu with medicinal plants among pharmacy customers in Estonia...
  58. ncbi Viral respiratory infections due to rhinoviruses: current knowledge, new developments
    A Mark Fendrick
    Department of Internal Medicine, School of Medicine, University of Michigan, Ann Arbor, MI, USA
    Am J Ther 10:193-202. 2003
    ..By targeting the cause of illness, antiviral agents represent an opportunity to reduce the substantial clinical burden of VRI. Furthermore, effective therapies can potentially reduce inappropriate antibiotic use for viral infections...
  59. pmc A human coronavirus responsible for the common cold massively kills dendritic cells but not monocytes
    Mariana Mesel-Lemoine
    Unité de Génomique Virale et Vaccination, Department of Virology, Institut Pasteur, CNRS URA 3015, Paris, France
    J Virol 86:7577-87. 2012
    ....
  60. ncbi Capturing the onset of the common cold and its effects on iron absorption
    M Hoppe
    Department of Clinical Nutrition, Institute of Internal Medicine, The Sahlgrenska Academy at Goteborg University, S 405 30 Gothenburg, Sweden
    Eur J Clin Nutr 61:1032-4. 2007
    ..However, to our best knowledge there are no previous published reports on the outbreak of a common cold and its initial effect on iron kinetics. The objective of this case report is to describe such an observation...
  61. ncbi Efficacy and safety of over-the-counter analgesics in the treatment of common cold and flu
    R Eccles
    Common Cold Centre, Cardiff School of Biosciences, Cardiff University, Cardiff, UK
    J Clin Pharm Ther 31:309-19. 2006
    b>Common cold and flu are the most common human illnesses, and over-the-counter (OTC) analgesics are widely used to treat the pain and fever symptoms...
  62. ncbi Safety and efficacy evaluation of pleconaril for treatment of the common cold
    Russell Fleischer
    Clin Infect Dis 37:1722. 2003
  63. pmc Predicting worsening asthma control following the common cold
    M J Walter
    Division of Pulmonary and Critical Care Medicine, Campus Box 8052, 660 South Euclid Ave, St Louis, MO 63110, USA
    Eur Respir J 32:1548-54. 2008
    The asthmatic response to the common cold is highly variable, and early characteristics that predict worsening of asthma control following a cold have not been identified...
  64. ncbi Treatment of the common cold with echinacea: a structured review
    Thomas J Caruso
    Stanford University School of Medicine, Stanford, CA, USA
    Clin Infect Dis 40:807-10. 2005
    Echinacea is a herbal preparation that is frequently used to treat the common cold. Spending on echinacea in the United States has risen to >300 million dollars annually.
  65. ncbi Safety and efficacy of over-the-counter cough and cold medicines for use in children
    Zdravko P Vassilev
    Epidemiology, Covance Periapproval Services, 555 North Lane, Suite 6000, Conshohocken, PA, USA
    Expert Opin Drug Saf 9:233-42. 2010
    ....
  66. pmc Placebo effects and the common cold: a randomized controlled trial
    Bruce Barrett
    University of Wisconsin, Madison, Madison, Wisconsin, USA
    Ann Fam Med 9:312-22. 2011
    We wanted to determine whether the severity and duration of illness caused by the common cold are influenced by randomized assignment to open-label pills, compared with conventional double-blind allocation to active and placebo pills, ..
  67. ncbi Herbs and other dietary supplements: current regulations and recommendations for use to maintain health in the management of the common cold or other related infectious respiratory illnesses
    Angelo Mathes
    Consultation Angelo Inc, Town of Mount Royal, QC, Canada
    J Pharm Pract 23:117-27. 2010
    ..The common cold is an important illness due to its recurring nature, the number of people it afflicts, and its economic impact ..
  68. ncbi Aircraft cabin air recirculation and symptoms of the common cold
    Jessica Nutik Zitter
    Department of Medicine, University of California, San Francisco, Box 0843, San Francisco, CA 94143 0843, USA
    JAMA 288:483-6. 2002
    ..Whether air recirculation increases the transmission of infectious disease is unknown; some studies have demonstrated higher rates of the common cold among persons working in buildings that recirculate air.
  69. ncbi Effects of So-cheong-ryong-tang and Yeon-gyo-pae-dok-san on the common cold: randomized, double blind, placebo controlled trial
    Jun Seop Byun
    Department of Internal Medicine, Oriental Medical College of Daejeon University, 96 3 Yongwun dong, Daejeon 300 716, South Korea
    J Ethnopharmacol 133:642-6. 2011
    So-cheong-ryong-tang (SCRT) and Yeon-gyo-pae-dok-san (YPS) extracts are widely used in treatment of the common cold. The purpose of this study is to evaluate the efficacy of SCRT and YPS on the common cold.
  70. ncbi Problems and prospects of developing effective therapy for common cold viruses
    S L Johnston
    University Medicine, Southampton General Hospital, UK
    Trends Microbiol 5:58-63. 1997
    ..These approaches offer new avenues for treating populations at risk and are of particular significance to those with asthma or chronic bronchitis...
  71. ncbi Intake of wine, beer, and spirits and the risk of clinical common cold
    Bahi Takkouche
    Department of Preventive Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
    Am J Epidemiol 155:853-8. 2002
    To examine whether intakes of wine, beer, spirits, and total alcohol are associated with the risk of common cold, in 1998-1999 the authors analyzed data from a cohort study carried out in a population of 4,272 faculty and staff of five ..
  72. pmc Hydrogen peroxide in breath condensate during a common cold
    R Q Jöbsis
    Department of Paediatrics, Division of Paediatric Respiratory Medicine, Erasmus University Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
    Mediators Inflamm 10:351-4. 2001
    ..Hydrogen peroxide (H2O2) in exhaled air condensate is elevated in inflammatory disorders of the lower respiratory tract. It is unknown whether viral colds contribute to exhaled H2O2...
  73. pmc The incidence, prevalence and burden of OM in unselected children aged 1-8 years followed by weekly otoscopy through the "common cold" season
    Ellen M Mandel
    Department of Otolaryngology, Children s Hospital of Pittsburgh and the University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Int J Pediatr Otorhinolaryngol 72:491-9. 2008
    ..Often overlooked in past studies are the contributions of cold-like illnesses (CLIs) and sampling interval to those estimates...
  74. ncbi Respiratory consequences of rhinovirus infection
    Stephen B Greenberg
    Department of Internal Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Arch Intern Med 163:278-84. 2003
    ..By altering the clinical course of picornavirus infections, it may be possible to minimize their potential adverse consequences...
  75. ncbi Efficacy of a pelargonium sidoides preparation in patients with the common cold: a randomized, double blind, placebo-controlled clinical trial
    Viktor G Lizogub
    Faculty Therapy No 2, National Medical University, Kiev, Ukraine
    Explore (NY) 3:573-84. 2007
    The common cold is a viral infection with symptoms such as sneezing, sore throat, and running nose...
  76. ncbi Evidence for correlation of objective and subjective measures of nasal airflow in patients with common cold
    J D Clarke
    Common Cold Centre, Cardiff School of Biosciences, Cardiff University, Cardiff, UK
    Clin Otolaryngol 30:35-8. 2005
    ..To utilize posterior rhinomanometry and conductance, as units of measurement, to further investigate the relationship between subjective and objective measures of nasal airflow...
  77. ncbi A clinical trial of hypertonic saline nasal spray in subjects with the common cold or rhinosinusitis
    P Adam
    Riverside University Family Practice Clinic, University of Minnesota Department of Family Practice and Community Health, Minneapolis 55406, USA
    Arch Fam Med 7:39-43. 1998
    To determine whether hypertonic saline nasal spray relieves nasal symptoms and shortens illness duration in patients with the common cold or acute rhinosinusitis.
  78. ncbi [Cough induction by high-frequency chest percussion in healthy volunteers and patients with common cold]
    P C L Lee
    Common Cold Centre, Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, UK
    Respir Med 98:771-6. 2004
    ..The aim of this study was to determine if cough can be induced by high-frequency chest percussion in healthy subjects and in patients with acute upper respiratory tract infection (URTI)...
  79. ncbi Visits by adults to family physicians for the common cold
    W J McIsaac
    Mt Sinai Family Medicine Centre, Toronto, Ontario, Canada
    J Fam Pract 47:366-9. 1998
    ..We examined how often a large population of adults visited doctors when they had a cold, the degree to which they engaged in self care, and the characteristics of those seeking care...
  80. ncbi Echinacea for preventing and treating the common cold
    Karin Woelkart
    Institute of Pharmaceutical Sciences, Department of Pharmacognosy, Karl Franzens University, Graz, Austria
    Planta Med 74:633-7. 2008
    Echinacea preparations are widely used for common cold. Many consumers and healthcare professionals are not aware that products available under the term Echinacea may differ in their composition, due to the use of different species, ..
  81. pmc Willingness to pay for health care services in common cold, retinal detachment, and myocardiac infarction: an internet survey in Japan
    Hideo Yasunaga
    Department of Planning, Information and Management, University of Tokyo Hospital, Tokyo, Japan
    BMC Health Serv Res 6:12. 2006
    ..The objective of this survey is to measure WTP for the treatment of typical acute illnesses and to analyze the factors affecting WTP...
  82. ncbi The prophylactic and therapeutic effectiveness of zinc sulphate on common cold in children
    Zafer Kurugol
    Department of Paediatrics, Faculty of Medicine, Ege University, Izmir, Turkey
    Acta Paediatr 95:1175-81. 2006
    To determine the efficacy of prophylactic administration of zinc sulphate in reducing the occurrence of the common cold in children, and to evaluate the efficacy of zinc sulphate in reducing the duration and severity of cold symptoms.
  83. ncbi Mechanisms of symptoms of the common cold and influenza
    Ron Eccles
    Common Cold Centre, Cardiff University, Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US
    Br J Hosp Med (Lond) 68:71-5. 2007
  84. ncbi Echinacea for prevention of the common cold: an illustrative overview of how information from different systematic reviews is summarised on the internet
    Anna Hart
    School of Public Health and Clinical Sciences, University of Central Lancashire, Harrington Building, Adelphi Street, Preston, Lancashire, PR1 2HE, UK
    Prev Med 49:78-82. 2009
    ..Our study objectives were to illustrate how selection criteria for trials in each of the reviews could lead to different conclusions, and to classify the ways in which webpage authors use the reviews to construct advice about echinacea...
  85. ncbi Zinc lozenges as cure for the common cold--a review and hypothesis
    George A Eby
    Director of Research, George Eby Research Institute, 14909 C Fitzhugh Road, Austin, TX 78736, USA
    Med Hypotheses 74:482-92. 2010
    ..the iZn hypothesis, lozenge iZn and total daily iZn in trials were found highly correlated with reductions in common cold durations with statistical significance for mean duration (P<0.001) and median duration (P<0...
  86. ncbi Vitamin C and acute respiratory infections
    H Hemilä
    Department of Public Health, University of Helsinki, Finland
    Int J Tuberc Lung Dis 3:756-61. 1999
    So far over 60 studies have examined the effects of vitamin C on the common cold. No effect on common cold incidence was observed in the six largest studies, indicating that vitamin C has no preventive effects in normally nourished ..
  87. pmc Sleep habits and susceptibility to the common cold
    Sheldon Cohen
    Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Arch Intern Med 169:62-7. 2009
    Sleep quality is thought to be an important predictor of immunity and, in turn, susceptibility to the common cold. This article examines whether sleep duration and efficiency in the weeks preceding viral exposure are associated with cold ..
  88. ncbi Relationship of upper and lower airway cytokines to outcome of experimental rhinovirus infection
    J E Gern
    Department of Pediatrics, University of Wisconsin Medical School, Madison, Wisconsin 53792 4108, USA
    Am J Respir Crit Care Med 162:2226-31. 2000
    ..cell type 1 (Th1)- and Th2-like cytokines induced by RV infection may help determine the clinical outcome of common cold infections, raising the possibility that the individual subject's immune response, rather than atopic status ..
  89. ncbi The Wisconsin Upper Respiratory Symptom Survey is responsive, reliable, and valid
    Bruce Barrett
    Department of Family Medicine, University of Wisconsin Medical School, Madison, 53715, USA
    J Clin Epidemiol 58:609-17. 2005
    ..To assess reliability, responsiveness, importance to patients, and convergent validity for the Wisconsin Upper Respiratory Symptom Survey (WURSS-44) and to develop a short-form WURSS...
  90. ncbi Prevalence of viral respiratory tract infections in children with asthma
    Nino Khetsuriani
    Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    J Allergy Clin Immunol 119:314-21. 2007
    ..Previous studies support a strong association between viral respiratory tract infections and asthma exacerbations. The effect of newly discovered viruses on asthma control is less well defined...
  91. ncbi Evaluation of echinacea for the prevention and treatment of the common cold: a meta-analysis
    Sachin A Shah
    University of Connecticut School of Pharmacy, Storrs, CT, USA
    Lancet Infect Dis 7:473-80. 2007
    ..commonly used herbal products, but controversy exists about its benefit in the prevention and treatment of the common cold. Thus, we did a meta-analysis evaluating the effect of echinacea on the incidence and duration of the common ..
  92. ncbi Echinacea purpurea therapy for the treatment of the common cold: a randomized, double-blind, placebo-controlled clinical trial
    Steven H Yale
    Department of Internal Medicine, Marshfield Clinic, and the Biostatistics and Bioinformatics Core, Marshfield Clinic Research Foundation, Marshfield, WI 54449, USA
    Arch Intern Med 164:1237-41. 2004
    ..We sought to determine the efficacy of a standardized preparation of E purpurea in reducing symptom severity and duration of the common cold.
  93. ncbi Pregnancy complications and delivery outcomes of pregnant women with common cold
    Ferenc Banhidy
    Second Department of Obstetrics and Gynecology, Semmelweis University, School of Medicine, Budapest, Hungary
    Cent Eur J Public Health 14:10-4. 2006
    To study the association between common cold during pregnancy and pregnancy complications and delivery outcomes: gestational age/birth weight, in addition preterm birth and low birthweight.
  94. ncbi Cough and the common cold
    F J Curley
    Division of Pulmonary Medicine, University of Massachusetts Medical School, Worcester 01655
    Am Rev Respir Dis 138:305-11. 1988
    To determine whether the cough of the common cold arises from upper respiratory stimuli and whether antihistamine-decongestant therapy is an effective treatment for this cough, we prospectively evaluated volunteers with uncomplicated ..
  95. ncbi Efficacy of Echinacea purpurea in patients with a common cold. A placebo-controlled, randomised, double-blind clinical trial
    B Schulten
    Company Medical Service, Madaus AG, Cologne, Germany
    Arzneimittelforschung 51:563-8. 2001
    ..Echinaceae purpureae herba (Echinacin, EC31J0) has shown promising results in the relief of common cold symptoms and the time taken to improvement compared to placebo...
  96. ncbi Nitric oxide and the common cold
    David Proud
    Respiratory Research Group and Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
    Curr Opin Allergy Clin Immunol 5:37-42. 2005
    The common cold is a clinical syndrome triggered by a variety of viral pathogens, but rhinoviruses are the most frequent cause...
  97. ncbi Efficacy of a standardized echinacea preparation (Echinilin) for the treatment of the common cold: a randomized, double-blind, placebo-controlled trial
    V Goel
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada
    J Clin Pharm Ther 29:75-83. 2004
    ..chosen most commonly by consumers with the expectation that it will reduce the severity and duration of the common cold. However, the results from a limited number of clinical trials for this application have thus far been ..
  98. ncbi Vitamin C, vitamin E, and beta-carotene in relation to common cold incidence in male smokers
    Harri Hemilä
    Department of Public Health, Universityof Helsinki, Finland
    Epidemiology 13:32-7. 2002
    ..E, and beta-carotene, as well as long-term vitamin E and beta-carotene supplementation, on the incidence of common cold episodes...
  99. ncbi Types of stressors that increase susceptibility to the common cold in healthy adults
    S Cohen
    Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Health Psychol 17:214-23. 1998
    ..They were then inoculated with common cold viruses and monitored for the onset of disease...
  100. ncbi Using benefit harm tradeoffs to estimate sufficiently important difference: the case of the common cold
    Bruce Barrett
    Department of Family Medicine, University of Wisconsin Medical School, Madison, WI 53715, USA
    Med Decis Making 25:47-55. 2005
    ..Little is known about patient preferences regarding benefits and harms of common cold treatments.
  101. ncbi Dynamics of stress-related decrease of salivary immunoglobulin A (sIgA): relationship to symptoms of the common cold and studying behavior
    R Deinzer
    Institute for Medical Psychology, Heinrich Heine University of Dusseldorf, Germany
    Behav Med 23:161-9. 1998
    ..However, no relationship between sIgA and URT symptoms was observed, nor did students who took academic examinations differ from untested controls in symptom rates...

Research Grants62

  1. Mechanisms and Enviromental Determinants of Rhinovirus Illness Severity
    James E Gern; Fiscal Year: 2013
    ..RELEVANCE: Rhinoviruses, originally known as "common cold viruses", also cause lower respiratory illnesses such as childhood wheezing, influenza-like illness, and ..
  2. Clinical Impact of Human Coronaviruses and Viral Diversity
    Geoffrey J Gorse; Fiscal Year: 2012
    ..The common cold, but also more severe illnesses involving the respiratory tract may result, including those similar to ..
  3. Mechanisms of viral proteases in coronavirus replication and pathogenesis
    Andrew D Mesecar; Fiscal Year: 2013
    ..positive strand RNA viruses which cause a range of illness, from relatively mild respiratory disease (croup and common cold like symptoms due to HCoV- NL63, 229e or OC43) to severe acute respiratory syndrome (SARS) outbreaks in humans...
  4. Systemic Application for Injury Site Specific Delivery via Neutrophils to Treat B
    XUDONG J LI; Fiscal Year: 2013
    ..problem and is the second most common reason that Americans go to see their doctor, second only to the most common cold and the flu...
  5. Enterovirus Vectors with Respiratory Tropism for Cancer Immunotherapy
    Matthias Gromeier; Fiscal Year: 2010
    ..We established a rodent model for the common cold in hICAM-1 transgenic mice, which exhibit modest virus replication in the respiratory tract and mild airway ..
  6. Role of TLR4 in Coronavirus Infection
    Steven M Varga; Fiscal Year: 2010
    ..HCoVs) are positive-stranded RNA viruses that are estimated to account for approximately 30% of cases of the common cold. The emergence of a novel HCoV as the etiologic agent of severe acute respiratory syndrome (SARS) demonstrated ..
  7. Development of the Cotton Rat Model of Rhinovirus Infection and Disease
    JORGE C BLANCO; Fiscal Year: 2013
    ..If successful, the proposed research will result in a valuable experimental resource to test vaccines and therapeutics against the "common cold".
  8. Chronic Rhinosinusitis Integrative Studies Program (CRISP)
    Robert P Schleimer; Fiscal Year: 2013
    ..are diagnosed with allergic rhinitis or episodes of ARS (symptoms for 7d to 4wk, to eliminate patients with the common cold);some of these patients progress to CRS with symptoms present for at least 12 weeks;many patients with CRS have ..
  9. Viral Protein Determinants of Coronavirus Replication Fidelity
    Everett Clinton Smith; Fiscal Year: 2013
    ..a family of positive-stranded RNA viruses that cause respiratory disease in humans ranging in severity from the common cold to severe acute respiratory syndrome (SARS)...
  10. Social Ties and Health: Aggregating Data from Five Viral-Challenge Trials
    Sheldon A Cohen; Fiscal Year: 2013
    ..studies (9 different viruses) focused on examining the roles of psychosocial factors in susceptibility to the common cold. In these unique studies, hypothesized predictor and mediating variables were assessed in healthy adults aged ..
  11. Innate Immunity in Otitis Media Pathogenesis
    David J Lim; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Following the common cold, otitis media (OM), or inflammation of the middle ear, is the most frequent illness resulting in visits to physicians and the most common cause of hearing impairment and ..
  12. Environmental Factors in Cognition and Neurobiology of Early Onset Schizophrenia
    Konasale M Prasad; Fiscal Year: 2013
    ..HSV1 is a double stranded DNA virus that causes common cold sores and requires lodging in the nervous system for its life cycle...
  13. Towards a Vaccine for the Common Cold
    THOMAS JAMES SMITH; Fiscal Year: 2010
    ..this highly diverse family of viruses and allow for a single, peptide-based vaccine that could ameliorate the common cold. Indeed, our preliminary evidence suggests that antiserum to such peptides does have pan-serotypic neutralizing ..
  14. Assembly of Picornaviral Replication Complexes
    Olve Peersen; Fiscal Year: 2009
    ..the heart disease causing coxsackie B3 virus, rhinoviruses that cause more than half the occurrences of the common cold, and the paralyzing poliovirus...
  15. PICORNAVIRUS MOLECULAR BIOLOGY
    Eckard Wimmer; Fiscal Year: 2013
    ..These infections lead to a variety of diseases ranging from the mild (common cold) to the serious (poliomyelitis)...
  16. Assembly of Picornaviral Replication Complexes
    OLVE BREIEN PEERSEN; Fiscal Year: 2013
    ..the heart disease causing coxsackie B3 virus, rhinoviruses that cause more than half the occurrences of the common cold, and the paralyzing poliovirus...
  17. PPG: SARS-CoV-host cell interactions and vaccine development
    Stanley Perlman; Fiscal Year: 2013
    ..will also investigate the role of ACE2 by comparing cells and mice infected with SARS-CoV and HCoV-NL63, a common cold virus that also uses ACE2 to enter cells but does not cause severe disease...
  18. Targeting Oral Biofilms with 2-Aminoimidazole/Triazole Conjugates
    Eva Garland; Fiscal Year: 2010
    ..Dental caries, or tooth decay, affects hundreds of millions of people each year, and is second only to the common cold in its prevalence world-wide...
  19. Flow-enhanced characterization of drug-resistant viruses
    John Yin; Fiscal Year: 2010
    ..AIDS), influenza, hepatitis, cancer, severe acute respiratory syndrome (SARS), hemorrhagic fever and the common cold. Quantitative assessments of virus infectivity are important in the clinic to test the performance of anti-..
  20. Developing ICAM-1 for rhinovirus therapeutics
    Moonsoo M Jin; Fiscal Year: 2010
    Human rhinoviruses (HRV) are the major causative agent of the common cold and the most common acute infectious illness in humans...
  21. Metabolomics of the Virus-host Cell Interaction
    Joshua D Rabinowitz; Fiscal Year: 2010
    ..Relevance: Viruses cause diseases ranging from the common cold to influenza to AIDS...
  22. Innovative Tools for In Vivo Computational Prediction of Lumbar Stresses
    RICHARD DAVID KOMISTEK; Fiscal Year: 2010
    ..medical problem in the United States, and the second most common reason for doctor visits behind the common cold. Lower back pain is the leading cause of disability among people ages 19-45 and is the leading cause of missed ..
  23. Effect of Rhinovirus on airway epithelial reciprocal pathways influence NK cells.
    Jonathan Koff; Fiscal Year: 2013
    ..RELEVANCE (See instructions): In addition to causing the common cold, Rhinovirus is responsible for causing exacerbations of chronic airway diseases (e.g. asthma)...
  24. Rates of rhinovirus species in adults and children with acute respiratory illness
    EVA KATHRYN MILLER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human rhinoviruses (HRV) are the leading cause of the common cold and more recently have been implicated in lower respiratory illness, in infants and children...
  25. Data-driven Computational Modeling of the Growth and Spread of Viruses
    John Yin; Fiscal Year: 2010
    ..Viruses also cause many human diseases including, for example, AIDS, influenza, cancer, SARS, and the common cold. Moreover, natural and engineered viruses have potential applications as vaccines and anti-cancer therapeutics...
  26. Phosphine-Catalyzed Annulations and Their Applications
    Ohyun Kwon; Fiscal Year: 2010
    ..The targets chosen are highly relevant to national public health, specifically the treatment of the common cold, hypertension, amoebic dysentery, malaria, arrhythmia, and cancer...
  27. DNA Analysis in Multi-Phase Microfabricated Devices
    Mark A Burns; Fiscal Year: 2010
    ..We will target pathogens associated with acute (the common cold) and chronic (multiple-species bacterial) respiratory infections for our main applications...
  28. Investigation and Development of New Therapeutic Avenues for Scleroderma
    EMANUAL M MAVERAKIS; Fiscal Year: 2011
    ..Public Health Relevance: Normally the immune system functions to fight off infections such as the common cold. In patients with autoimmunity the cells of the immune system damage the tissues and organs of a patient...
  29. MOLECULAR BIOLOGY OF POLIOVIRUS RNA REPLICATION
    James Bert Flanegan; Fiscal Year: 2010
    ..with these viruses include paralytic poliomyelitis, meningitis, encephalitis, myocarditis, hepatitis and the common cold. Post-polio syndrome is also an important clinical manisfestation that occurrs in patients 30-40 years after ..
  30. Evolution of Virus-Host Interactions
    John Yin; Fiscal Year: 2013
    ..to human health based on their ability to cause diseases such as AIDS, influenza, hepatitis, cancer and the common cold. Basic research has revealed much about the molecular details of processes that are essential for viruses to ..
  31. CONFERENCE ON POSITIVE-STRAND RNA VIRUSES
    MARGO BRINTON; Fiscal Year: 1992
    ..from positive-strand RNA virus infections includes encephalitis, poliomyelitis, heart disease, hepatitis, the common cold, gastroenteritis, hemorrhagic fever, and birth defects...
  32. A Data-mining Approach to CAM Medication Reconciliation
    WILLIAM Z TAN; Fiscal Year: 2012
    ..Phase I activities will generate a prototype for evaluating one frequently encountered condition: the common cold. This prototype will provide a solid foundation for system expansion, in Phase II, to cover a broad range of ..
  33. Transgenic Mouse Model for the Common Cold
    Matthias Gromeier; Fiscal Year: 2009
    ..Despite the generally benign course of the common cold caused by picornaviruses, it is the main culprit for acute exacerbation of serious respiratory system disorders,..
  34. CONFERENCE ON POSITIVE-STRAND RNA VIRUSES
    MARGO BRINTON; Fiscal Year: 2001
    ..Human encephalitis, poliomyelitis, heart disease, hepatitis, the common cold, gastroenteritis, haemorrhagic fever, eye infections, and birth defects are caused by positive-strand RNA ..
  35. STRUCTURE OF POLIOVIRUS/ANTIVIRAL DRUG COMPLEXES
    JAMES HOGLE; Fiscal Year: 1991
    ..These drugs are of considerable medical and economic significance for prophylaxis of rhinovirus induced common cold (which account for 80% of the colds in the United States) and for early intervention in poliomyelitis and ..
  36. BIOELASTIC MATERIAL TO PREVENT POST-LAMINECTOMY ADHESION
    Jie Xu; Fiscal Year: 2001
    ..APPLICATION: Low back pain, for which intervertebral disc pathology is the major cause, is second only to the common cold for work absenteeism in the United States; it is reported to result in more productivity loss than any other ..
  37. INHIBITION OF NUCLEO-CYTOPLASMIC TRANSPORT BY RHINOVIRUS
    KURT GUSTIN; Fiscal Year: 2005
    The most prevalent form of viral respiratory illness is the common cold, which is itself most often associated with infection by rhinovirus...
  38. A NETWORK OF RESEARCH UNITS TO STUDY CLINICAL WOUND CARE
    James Quinn; Fiscal Year: 2004
    DESCRIPTION (Taken from the applicants abstract): Next to the common cold, traumatic wounds are the most common reasons people seek medical care in the United States. An estimated 3...
  39. Exhaled Biomarkers During Treatment of Rhinovirus
    John Hunt; Fiscal Year: 2004
    ..The mechanisms by which this common cold virus caused alteration in airway physiology are not well characterized in part because of the difficulty of ..
  40. TRANSLATION-INHIBITION OF HEPATITIS C AND POLIO VIRUSES
    Asim Dasgupta; Fiscal Year: 2003
    ..A) and chronic hepatitis (hepatitis C), common cold (rhinovirus), and myocarditis and encephalitis (coxsackie) among others...
  41. BIOELASTIC MATERIALS FOR INTERVERTEBRAL DISC RESTORATION
    Asima Pattanaik; Fiscal Year: 1999
    ..APPLICATIONS: Low back pain, for which intervertebral disc pathology is the major cause, is second only to the common cold for work absenteeism in the United States; it is reported to result in more productivity loss than any other ..
  42. STRUCTURE AND FUNCTION OF THE POLIOVIRUS RNA GENOME
    Peter Sarnow; Fiscal Year: 1991
    ..knowledge of the structure and function of the poliovirus genome might be applicable to the genomes of other medically important RNA viruses such as foot and mouth disease virus and human rhinovirus, responsible for the common cold.
  43. Optimization of Codon-Pair Usage to Maximize Protein Expression in Plants
    KEITH WYCOFF; Fiscal Year: 2007
    ..intoxication by Botulinum Neurotoxin A (BoNT/A), the most potent toxin known and a bio-terror agent, the common cold, dental caries and intoxication by Anthrax toxin, also a bio-terror agent...
  44. RECENT ADVANCES IN OTITIS MEDIA--RESEARCH CONFERENCE
    Thomas Demaria; Fiscal Year: 1991
    ..OM is second only to the common cold as the most common children's disease in the U.S...
  45. RECENT ADVANCES IN OTITIS MEDIA--RESEARCH CONFERENCE
    David Lim; Fiscal Year: 1999
    ..Otitis Media is second only to the common cold as the most common children's disease in the United States...
  46. CORONAVIRUS-RECEPTOR INTERACTIONS
    Kathryn Holmes; Fiscal Year: 2003
    ..viruses that cause most common colds, such combination drugs would make it unnecessary to identify the type of common cold virus causing early symptoms before initiating therapy...
  47. System to Detect Severe Respiratory Illness by Vocalization Analysis of Cough
    Suzanne Smith; Fiscal Year: 2009
    ..as tuberculosis, pertussis and influenza from those with coughs related to less serious conditions such as the common cold. PUBLIC HEALTH RELEVANCE: We propose to use vocalization analysis software to characterize coughs...
  48. Novel Cap Analogs and Interactions with Target Proteins
    ROBERT RHOADS; Fiscal Year: 2005
    ..They also have relevance for diseases caused by picornaviruses such as poliovirus (polio), rhinovirus (the common cold) and Coxsackievirus (heart failure), since picomaviruses shut down cap-dependent translation by proteolytically ..
  49. Viral-Driven Mediators of Chronic Lung Allograft Dysfunction
    Richard Pierce; Fiscal Year: 2009
    ..In lay terms, we have previously shown that the common cold, or a respiratory viral infection, is associated with chronic lung disease in people that have had a lung ..
  50. Temperature-dependent, Intermediate Particles from the Entry of Picornaviruses in
    David Belnap; Fiscal Year: 2009
    ..Understanding the entry process of picornaviruses will give a fuller mechanistic picture of how these and other viruses cause disease and may give insights into anti-viral therapies. ..
  51. Nitration immunology
    John Hunt; Fiscal Year: 2005
    ..and compare these conditions to those found in the airways during inflammation such as occurs with the common cold. Expanding upon supportive preliminary data, we will concurrently investigate the potential of nitrated ..
  52. Recent Advancees in Otitis Media: Research Conference
    David Lim; Fiscal Year: 2003
    Following the common cold, otitis media (OM), or inflammation of the middle ear, is the most frequent illness resulting in visits to physicians and the most common cause of hearing impairment in children...
  53. Amplicon Plus for High-Level Expression of Therapeutic Proteins in Plants
    KEITH WYCOFF; Fiscal Year: 2005
    ..a recombinant therapeutic protein that is being developed by Planet Biotechnology for prevention of the common cold. The overall plan for the Phase I research is to design and construct amplicon-plus transgenic plants to ..
  54. Placebo: Physician or Pill? RCT in a commom cold model
    Bruce Barrett; Fiscal Year: 2006
    ..The nature and magnitude of placebo effects, however, is very poorly understood. Specific aims. Using a common cold model, this study will assess two kinds of "placebo effects": 1) the effect of receiving blinded placebo, ..
  55. Structural Studies of Virus Assembly & DNA Packaging
    MARC MORAIS; Fiscal Year: 2004
    ..Viral infection is a significant cause of human illness, ranging from relatively minor ailments such as the common cold to life threatening diseases such as cancer and AIDS...
  56. Data-driven Computational Modeling of the Growth and Spread of Viruses
    John Yin; Fiscal Year: 2007
    ..Viruses also cause many human diseases including, for example, AIDS, influenza, cancer, SARS, and the common cold. Moreover, natural and engineered viruses have potential applications as vaccines and anti-cancer therapeutics...
  57. Tetravalent Humanized Anti-ICAM for Rhinovirus Infection
    Fang Fang; Fiscal Year: 2001
    The common cold is the most prevalent disease affecting humans, and 70 percent of cases are caused by rhinoviruses (HRV)...
  58. Rhinovirus accelerates wound repair via surface signaling EGFR activation
    Jonathan Koff; Fiscal Year: 2007
    ..RV infection has clinical importance because the virus is the predominant cause of the common cold and causes exacerbations of asthma and COPD...
  59. Human Coronaviruses as Multigene Mucosal Vaccine Vectors for HIV
    Amy Sims; Fiscal Year: 2009
    ..The common cold human coronavirus (HCoV) OC43 is attractive as a vaccine vector for HIV, and recent breakthroughs in ..
  60. LBP with Radiculopathy: An Inflammatory Response
    JOYCE DELEO; Fiscal Year: 2005
    Low back pain is a major clinical problem second only to the common cold in its financial and symptomatic impact on human suffering...
  61. Affinity Enhancement of a Humanized Anti-ICAM Antibody
    Fang Fang; Fiscal Year: 2001
    The common cold is a benign disease that also causes ear infections in children and is a leading cause of "attacks" in asthmatic patients...
  62. Novel Treatment for Parkinson's Disease
    Dale Christensen; Fiscal Year: 2007
    ..PD treatment is currently more like a common cold, with drugs that alleviate symptoms but do not address the underlying cause of the disease...