allergic bronchopulmonary aspergillosis

Summary

Summary: Aspergillosis of the lung occurring in an individual with long-standing bronchial asthma. It is characterized by pulmonary infiltrates, eosinophilia, elevated serum IgE and immediate type skin reactivity to aspergillus antigen.

Top Publications

  1. ncbi Allergic bronchopulmonary aspergillosis: a rare cause of pleural effusion
    T M O'Connor
    Department of Respiratory Medicine, Cork University Hospital, Wilton, Cork, Ireland
    Respirology 6:361-3. 2001
  2. ncbi Aspergillus hypersensitivity and allergic bronchopulmonary aspergillosis in patients with bronchial asthma: systematic review and meta-analysis
    R Agarwal
    Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Int J Tuberc Lung Dis 13:936-44. 2009
  3. ncbi Allergic bronchopulmonary aspergillosis
    Paul A Greenberger
    Division of Allergy Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Allergy Clin Immunol 110:685-92. 2002
  4. ncbi Disease-specific recombinant allergens for the diagnosis of allergic bronchopulmonary aspergillosis
    R Crameri
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Int Immunol 10:1211-6. 1998
  5. ncbi Nasal septal perforation in a patient with allergic bronchopulmonary aspergillosis and rhinitis on long term corticosteroids
    D Deepak
    Department of Respiratory Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, India
    Asian Pac J Allergy Immunol 19:287-90. 2001
  6. ncbi Enhanced pulmonary allergic responses to Aspergillus in CCR2-/- mice
    K Blease
    Department of Pathology, Division of Pulmonary and Critical Care, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 165:2603-11. 2000
  7. ncbi Antifungal and airway remodeling roles for murine monocyte chemoattractant protein-1/CCL2 during pulmonary exposure to Asperigillus fumigatus conidia
    K Blease
    Department of Pathology, Division of Pulmonary and Critical Care, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 166:1832-42. 2001
  8. doi Allergic bronchopulmonary aspergillosis
    Ritesh Agarwal
    Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Chest 135:805-26. 2009
  9. ncbi Two year follow-up of a garbage collector with allergic bronchopulmonary aspergillosis (ABPA)
    H Allmers
    Berufsgenossenschaftliches Forschungsinstitut fur Arbeitsmedizin BGFA, Institut an der Ruhr Universität Bochum, Germany
    Am J Ind Med 37:438-42. 2000
  10. ncbi Allergic bronchopulmonary aspergillosis
    Richard B Moss
    Department of Pediatrics, Stanford University, Palo Alto, CA, USA
    Clin Rev Allergy Immunol 23:87-104. 2002

Detail Information

Publications211 found, 100 shown here

  1. ncbi Allergic bronchopulmonary aspergillosis: a rare cause of pleural effusion
    T M O'Connor
    Department of Respiratory Medicine, Cork University Hospital, Wilton, Cork, Ireland
    Respirology 6:361-3. 2001
    Aspergillus fumigatus is one of the most ubiquitous of the airborne saprophytic fungi. Allergic bronchopulmonary aspergillosis (ABPA) is a syndrome seen in patients with asthma and cystic fibrosis, and is characterized by ..
  2. ncbi Aspergillus hypersensitivity and allergic bronchopulmonary aspergillosis in patients with bronchial asthma: systematic review and meta-analysis
    R Agarwal
    Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Int J Tuberc Lung Dis 13:936-44. 2009
    The prevalence of Aspergillus hypersensitivity (AH) and allergic bronchopulmonary aspergillosis (ABPA) in bronchial asthma is reported differently in various studies.
  3. ncbi Allergic bronchopulmonary aspergillosis
    Paul A Greenberger
    Division of Allergy Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Allergy Clin Immunol 110:685-92. 2002
    b>Allergic bronchopulmonary aspergillosis (ABPA) complicates asthma and cystic fibrosis. The survival factors in Aspergillus fumigatus that support saprophytic growth in bronchial mucus are not understood...
  4. ncbi Disease-specific recombinant allergens for the diagnosis of allergic bronchopulmonary aspergillosis
    R Crameri
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Int Immunol 10:1211-6. 1998
    b>Allergic bronchopulmonary aspergillosis (ABPA), a severe pulmonary complication caused by Aspergillus fumigatus, is considered a complex clinical syndrome with defined serological, pathological radiological and clinical features...
  5. ncbi Nasal septal perforation in a patient with allergic bronchopulmonary aspergillosis and rhinitis on long term corticosteroids
    D Deepak
    Department of Respiratory Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, India
    Asian Pac J Allergy Immunol 19:287-90. 2001
    A 22-year-old male, referred to us as a case of multi-drug resistant tuberculosis was diagnosed as allergic bronchopulmonary aspergillosis (ABPA) after serological and computed tomography confirmation...
  6. ncbi Enhanced pulmonary allergic responses to Aspergillus in CCR2-/- mice
    K Blease
    Department of Pathology, Division of Pulmonary and Critical Care, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 165:2603-11. 2000
    ..Thus, these findings demonstrate that CCR2 plays an important role in the immune response against A. fumigatus, thereby limiting the allergic airway inflammatory and remodeling responses to this fungus...
  7. ncbi Antifungal and airway remodeling roles for murine monocyte chemoattractant protein-1/CCL2 during pulmonary exposure to Asperigillus fumigatus conidia
    K Blease
    Department of Pathology, Division of Pulmonary and Critical Care, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 166:1832-42. 2001
    ..These data suggest that MCP-1/CCL2 participates in the pulmonary antifungal and allergic responses to A. fumigatus conidia...
  8. doi Allergic bronchopulmonary aspergillosis
    Ritesh Agarwal
    Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Chest 135:805-26. 2009
    b>Allergic bronchopulmonary aspergillosis (ABPA) is an immunologic pulmonary disorder caused by hypersensitivity to Aspergillus fumigatus...
  9. ncbi Two year follow-up of a garbage collector with allergic bronchopulmonary aspergillosis (ABPA)
    H Allmers
    Berufsgenossenschaftliches Forschungsinstitut fur Arbeitsmedizin BGFA, Institut an der Ruhr Universität Bochum, Germany
    Am J Ind Med 37:438-42. 2000
    ..Bronchial challenge testing with commercially available Aspergillus fumigatus extract resulted in an immediate-type asthmatic reaction. Two years later he was still symptomatic and antibodies persisted at lower levels...
  10. ncbi Allergic bronchopulmonary aspergillosis
    Richard B Moss
    Department of Pediatrics, Stanford University, Palo Alto, CA, USA
    Clin Rev Allergy Immunol 23:87-104. 2002
    b>Allergic bronchopulmonary aspergillosis (ABPA) is a common complication of cystic fibrosis (CF), occurring in approximately 10% of patients and accompanying/accounting for approximately 10% of pulmonary exacerbations...
  11. doi Measured immunoglobulin E in allergic bronchopulmonary aspergillosis treated with omalizumab
    Robert Y Lin
    Department of Medicine, St Vincent s Hospital Manhattan Saint Vincent s Catholic Medical Centers, New York, New York, USA
    J Asthma 47:942-5. 2010
    The ability to assess adequate reductions in immunoglobulin E (IgE) in allergic bronchopulmonary aspergillosis (ABPA) has been a concern with regards to omalizumab treatment.
  12. ncbi Increased sensitivity to IL-4 in cystic fibrosis patients with allergic bronchopulmonary aspergillosis
    A P Knutsen
    Division of Allergy and Immunology, Saint Louis University Health Sciences Center, St Louis, MO 63110, USA
    Allergy 59:81-7. 2004
    b>Allergic bronchopulmonary aspergillosis (ABPA) is characterized by a heightened Th2 CD4+ T-cell response to Aspergillus fumigatus allergens and a hyper-immunoglobulin (Ig)E state compared with cystic fibrosis patients without ABPA...
  13. ncbi Chemokines indicate allergic bronchopulmonary aspergillosis in patients with cystic fibrosis
    Dominik Hartl
    Department of Pediatrics, University Hospital of Berne, Switzerland
    Am J Respir Crit Care Med 173:1370-6. 2006
    b>Allergic bronchopulmonary aspergillosis (ABPA) is characterized by a Th2 immune response...
  14. ncbi Diagnosis and treatment of allergic bronchopulmonary aspergillosis
    N E Vlahakis
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 76:930-8. 2001
    b>Allergic bronchopulmonary aspergillosis (ABPA) is an underdiagnosed pulmonary disorder in asthmatic patients and patients with cystic fibrosis...
  15. ncbi Frequency of cystic fibrosis transmembrane conductance regulator gene mutations and 5T allele in patients with allergic bronchopulmonary aspergillosis
    E Marchand
    Service de Pneumologie, Cliniques Universitaires de Mont Godinne, Universite Catholique de Louvain, Yvoir, Belgium
    Chest 119:762-7. 2001
    To assess the frequency of cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in patients with allergic bronchopulmonary aspergillosis (ABPA).
  16. ncbi Induced sputum IL-8 gene expression, neutrophil influx and MMP-9 in allergic bronchopulmonary aspergillosis
    P G Gibson
    Dept of Respiratory and Sleep Medicine, John Hunter Hospital and School of Medical Practice and Population Health, Faculty of Health, University of Newcastle, Newcastle, NSW, Australia
    Eur Respir J 21:582-8. 2003
    b>Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity reaction to the fungus Aspergillus fumigatus, causing severe asthma that may progress to bronchiectasis...
  17. ncbi Allergic bronchopulmonary aspergillosis
    Baiju Malde
    Northwestern University, Department of Medicine, USA
    Allergy Asthma Proc 25:S38-9. 2004
  18. ncbi Current pharmacotherapy of allergic bronchopulmonary aspergillosis
    M A Judson
    Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston, USA
    Expert Opin Pharmacother 2:1065-71. 2001
    ..carried out, the available data support the use of corticosteroids for acute exacerbations of allergic bronchopulmonary aspergillosis (ABPA)...
  19. ncbi Clinical aspects of allergic bronchopulmonary aspergillosis
    Paul A Greenberger
    Division of Allergy Immunology and the Ernest S Bazley Asthma and Allergic Diseases Center, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Front Biosci 8:s119-27. 2003
    b>Allergic Bronchopulmonary Aspergillosis (ABPA) is characterized by recurrent pulmonary infiltrates that can result in central bronchiectasis and bronchiolitis obliterans especially if there is a lack of recognition and treatment...
  20. ncbi Cytokines and chemokines in allergic bronchopulmonary aspergillosis (ABPA) and experimental Aspergillus-induced allergic airway or asthmatic disease
    Cory M Hogaboam
    Department of Pathology, University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, MI 48109 0602, USA
    Front Biosci 8:e147-56. 2003
    b>Allergic bronchopulmonary aspergillosis (ABPA) is a devastating clinical disease that results from an aggressive pulmonary allergic response to the antigens released by colonizing Aspergillus fumigatus (A...
  21. ncbi Nontuberculous mycobacteria in cystic fibrosis associated with allergic bronchopulmonary aspergillosis and steroid therapy
    H Mussaffi
    Kathy and Lee Graub Cystic Fibrosis Center and Pulmonary Unit, Schneider Children s Medical Center of Israel, 14 Kaplan Street, Petah Tikva, 49202, Israel
    Eur Respir J 25:324-8. 2005
    ..3%) met the criteria for NTM pulmonary disease (five with M. abscessus). Five had allergic bronchopulmonary aspergillosis (ABPA) compared with one out of 133 patients without NTM disease...
  22. ncbi Identification of 45 kD antigen in immune complexes of patients of allergic bronchopulmonary aspergillosis
    T Madan
    Centre for Biochemical Technology, Delhi University Campus, India
    Mol Cell Biochem 166:111-6. 1997
    ..kD was observed to be predominant in the circulating immune complexes isolated from patients of allergic bronchopulmonary aspergillosis as well as in the immune complexes prepared in vitro...
  23. ncbi Prevalence of allergic bronchopulmonary aspergillosis in cystic fibrosis in an area with a high frequency of atopy
    Marianne Skov
    Department of Respiratory Medicine, The CF Clinic, The Children s Hospital at Westmead, Rigshopitalet, Copenhagen, Denmark
    Respir Med 99:887-93. 2005
    ..Lower airway colonisation with Aspergillus fumigatus and the complicating hypersensitivity reaction allergic bronchopulmonary aspergillosis (ABPA) is well recognised in patients with cystic fibrosis (CF)...
  24. doi Serologic diagnosis of allergic bronchopulmonary aspergillosis in patients with cystic fibrosis through the detection of immunoglobulin G to Aspergillus fumigatus
    Richard C Barton
    Department of Microbiology, Leeds Teaching Hospitals Trust, Leeds, UK
    Diagn Microbiol Infect Dis 62:287-91. 2008
    b>Allergic bronchopulmonary aspergillosis (ABPA) is seen in approximately 10% of patients with cystic fibrosis (CF) and can be difficult to diagnose...
  25. ncbi Allergic bronchopulmonary aspergillosis
    B A Cockrill
    Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, USA
    Annu Rev Med 50:303-16. 1999
    b>Allergic bronchopulmonary aspergillosis (ABPA) is a syndrome seen in patients with asthma and cystic fibrosis. It is characterized by chronic colonization of the airways with a ubiquitous fungus, Aspergillus fumigatus...
  26. ncbi Allergic bronchopulmonary aspergillosis without clinical asthma caused by Aspergillus niger
    A Shah
    Department of Respiratory Medicine Vallabhbhai Patel Chest Institute University of Delhi P O Box 2101 Delhi 110007 India
    Allergy 59:236-7. 2004
  27. ncbi [Clinical and pathological analysis of allergic bronchopulmonary aspergillosis in China]
    Feng Ye
    Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical College, Guangzhou 510120, China
    Zhonghua Jie He He Hu Xi Za Zhi 32:434-8. 2009
    To describe the clinical features and diagnosis of allergic bronchopulmonary aspergillosis (ABPA).
  28. ncbi Sensitization to Aspergillus antigens and occurrence of allergic bronchopulmonary aspergillosis in patients with asthma
    Vikas Maurya
    Department of Respiratory Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, PO Box 2101, Delhi 110 007, India
    Chest 127:1252-9. 2005
    b>Allergic bronchopulmonary aspergillosis (ABPA), which is predominantly a disease of asthmatic subjects, is caused by hypersensitivity to Aspergillus antigens...
  29. ncbi Allergic bronchopulmonary aspergillosis in cystic fibrosis--state of the art: Cystic Fibrosis Foundation Consensus Conference
    David A Stevens
    Department of Medicine, Santa Clara Valley Medical Center, Stanford University Medical School, San Jose, California 95128 2699, USA
    Clin Infect Dis 37:S225-64. 2003
    Because of the difficulties of recognizing allergic bronchopulmonary aspergillosis (ABPA) in the context of cystic fibrosis (because of overlapping clinical, radiographic, microbiologic, and immunologic features), advances in our ..
  30. ncbi Case report: allergic bronchopulmonary aspergillosis and allergic fungal sinusitis successfully treated with voriconazole
    Gary E Erwin
    Pulmonary and Critical Care Medicine, Dallas Diagnostic Association, Plano, Texas 75093, USA
    J Asthma 44:891-5. 2007
    b>Allergic bronchopulmonary aspergillosis and allergic fungal sinusitis are closely related disorders that rarely present in the same individual...
  31. ncbi Allergic bronchopulmonary aspergillosis
    Peter G Gibson
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, University of Newcastle, NSW, Australia
    Semin Respir Crit Care Med 27:185-91. 2006
    b>Allergic bronchopulmonary aspergillosis is an uncommon but serious respiratory condition characterized by chronic airway inflammation and airway damage resulting from persistent colonization by and sensitization to the fungus Aspergillus ..
  32. ncbi Pulmonary hypertension as a presenting manifestation of allergic bronchopulmonary aspergillosis
    Ritesh Agarwal
    Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Indian J Chest Dis Allied Sci 51:37-40. 2009
    ..Identification of the disease, in its early-stage, can prevent progression to bronchiectasis and fibrotic lung disease, and thus, patients can be saved from the morbidity related to end-stage disease...
  33. ncbi Contemporaneous occurrence of allergic bronchopulmonary aspergillosis, allergic Aspergillus sinusitis, and aspergilloma
    Ashok Shah
    Department of Respiratory Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India
    Ann Allergy Asthma Immunol 96:874-8. 2006
    ..The coexistence of allergic bronchopulmonary aspergillosis (ABPA) with aspergilloma is uncommon, whereas concurrent ABPA and allergic Aspergillus sinusitis (..
  34. doi Aspergillus endocarditis in a known case of allergic bronchopulmonary aspergillosis: an autopsy report
    Kirti Gupta
    Department of Histopathology, Post Graduate Institute of Medical Education and Research, PGIMER, Chandigarh, India
    Cardiovasc Pathol 19:e137-9. 2010
    ..This is an uncommon case of a 60-year-old asthmatic male who developed allergic bronchopulmonary aspergillosis during the course of his illness, and while receiving low dose oral steroids, he subsequently ..
  35. ncbi Allergic bronchopulmonary aspergillosis with hilar adenopathy in a 42-month-old boy
    Ashok Shah
    Pediatr Pulmonol 42:747-8. 2007
  36. ncbi Allergic bronchopulmonary aspergillosis: a review of a disease with a worldwide distribution
    Ashok Shah
    Department of Respiratory Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, India
    J Asthma 39:273-89. 2002
    b>Allergic bronchopulmonary aspergillosis (ABPA), an immunologically mediated lung disease, occurs predominantly in patients with asthma...
  37. ncbi Risk factors for allergic bronchopulmonary aspergillosis and sensitisation to Aspergillus fumigatus in patients with cystic fibrosis
    Nicole Ritz
    Department of Paediatrics, University of Berne, 3010 Berne, Switzerland
    Eur J Pediatr 164:577-82. 2005
    An increasing incidence of allergic bronchopulmonary aspergillosis (ABPA) as a complication in patients with cystic fibrosis (CF) is reported...
  38. ncbi Anti-inflammatory effect of itraconazole in stable allergic bronchopulmonary aspergillosis: a randomized controlled trial
    Peter Alexander Blanch Wark
    Faculty of Health, University of Newcastle, and the Department of Respiratory and Sleep Medicine and the Airways Infection and Immunology Research Group, John Hunter Hospital, Newcastle, Australia
    J Allergy Clin Immunol 111:952-7. 2003
    b>Allergic bronchopulmonary aspergillosis (ABPA) complicates chronic asthma and results from hypersensitivity to the fungus Aspergillus fumigatu s, causing an intense systemic immune response and progressive lung damage.
  39. pmc Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis
    G Grunig
    Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304, USA
    J Exp Med 185:1089-99. 1997
    ..We conclude that IL-10 can suppress inflammatory Th2-like lung responses as well as Th1-like responses given the constraints of genetic background and route of priming...
  40. ncbi Allergic bronchopulmonary aspergillosis in the asthma clinic. A prospective evaluation of CT in the diagnostic algorithm
    T Eaton
    Green Lane Hospital, Auckland, New Zealand
    Chest 118:66-72. 2000
    b>Allergic bronchopulmonary aspergillosis (ABPA) occurs in cases of atopic asthma and may result in important lung disease. Early diagnosis is essential as this disease is responsive to steroids...
  41. ncbi Allergic bronchopulmonary aspergillosis: lessons from 126 patients attending a chest clinic in north India
    Ritesh Agarwal
    Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Chest 130:442-8. 2006
    To describe the experience of screening patients with asthma for allergic bronchopulmonary aspergillosis (ABPA) presenting to a chest clinic...
  42. ncbi [Refractory asthma: diagnosing allergic bronchopulmonary aspergillosis]
    Andre Bernard Tonnel
    Service de Pneumologie et d Immuno Allergologie, Hopital Calmette, CHRU de Lille, F 59037 Lille Cedex, France
    Presse Med 37:161-6. 2008
    b>Allergic bronchopulmonary aspergillosis (ABPA) results from a twofold mechanism: Th2-like hypersensitivity reaction and bronchial colonization by Aspergillus fumigatus...
  43. doi Allergic bronchopulmonary aspergillosis
    Karen Patterson
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL 60637, USA
    Proc Am Thorac Soc 7:237-44. 2010
    b>Allergic bronchopulmonary aspergillosis (ABPA) is a complex clinical entity that results from an allergic immune response to Aspergillus fumigatus, most often occurring in a patient with asthma or cystic fibrosis...
  44. doi Case report: A rare cause of miliary nodules -- allergic bronchopulmonary aspergillosis
    R Agarwal
    Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Br J Radiol 82:e151-4. 2009
    b>Allergic bronchopulmonary aspergillosis (ABPA) is a complex immune hypersensitivity reaction to the fungus Aspergillus fumigatus, which occurs in patients with asthma and cystic fibrosis...
  45. ncbi Immunopathogenesis of allergic bronchopulmonary aspergillosis and airway remodeling
    Henk F Kauffman
    University Hospital Groningen, Department of Allergology, Clinic for Internal Medicine, Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
    Front Biosci 8:e190-6. 2003
    b>Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity lung disease clinically characterized by manifestation of wheezing, pulmonary infiltrates and bronchiectasis and fibrosis which afflicts asthmatic and cystic fibrosis (..
  46. ncbi Clinical significance of hyperattenuating mucoid impaction in allergic bronchopulmonary aspergillosis: an analysis of 155 patients
    Ritesh Agarwal
    Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Chest 132:1183-90. 2007
    b>Allergic bronchopulmonary aspergillosis (ABPA) is a disease that presents with diverse clinicoradiologic manifestations...
  47. ncbi HLA-DRB1 alleles control allergic bronchopulmonary aspergillosis-like pulmonary responses in humanized transgenic mice
    Sherri Koehm
    Department of Molecular Microbiology and Immunology, Saint Louis University, St Louis, MO, USA
    J Allergy Clin Immunol 120:570-7. 2007
    b>Allergic bronchopulmonary aspergillosis (ABPA) is a lung hypersensitivity disease mediated in part by CD4(+) T(H)2 cells...
  48. ncbi Association of polymorphisms in the collagen region of SP-A2 with increased levels of total IgE antibodies and eosinophilia in patients with allergic bronchopulmonary aspergillosis
    Shweta Saxena
    Molecular Biochemistry and Diagnostics Division, Institute of Genomics and Integrative Biology, Delhi, India
    J Allergy Clin Immunol 111:1001-7. 2003
    ..Studies from our group have shown a protective role of pulmonary surfactant protein A (SP-A) against lung allergy and infections caused by Aspergillus fumigatus...
  49. ncbi Allergic bronchopulmonary aspergillosis: a US perspective
    Christine Virnig
    William S Middleton VA Hospital, Madison, Wisconsin 53705, USA
    Curr Opin Pulm Med 13:67-71. 2007
    The present article is an update of allergic bronchopulmonary aspergillosis. Although a rare condition, allergic bronchopulmonary aspergillosis does affect a number of patients with asthma and cystic fibrosis...
  50. ncbi [A case of pleural effusion associated with allergic bronchopulmonary aspergillosis during a relapse of the disease]
    Takashi Ogasawara
    Division of Respiratory Disease, Seirei Hamamatsu Hospital, 2 12 12 Sumiyoshi, Hamamatsu, Shizuoka 430 8558, Japan
    Nihon Kokyuki Gakkai Zasshi 41:905-10. 2003
    ..b>Allergic bronchopulmonary aspergillosis (ABPA) was diagnosed on the basis of the following findings: elevated serum IgE level, positive ..
  51. ncbi Comparison of serum markers for allergic bronchopulmonary aspergillosis in cystic fibrosis
    P Latzin
    Division of Respiratory Medicine, Dept of Paediatrics, University Children s Hospital of Bern, Inselspital, 3010 Bern, Switzerland
    Eur Respir J 31:36-42. 2008
    The diagnosis of allergic bronchopulmonary aspergillosis (ABPA) in cystic fibrosis (CF) is a challenge. Thymus- and activation-regulated chemokine (TARC) has recently been reported to play a role in ABPA...
  52. pmc Vitamin D3 attenuates Th2 responses to Aspergillus fumigatus mounted by CD4+ T cells from cystic fibrosis patients with allergic bronchopulmonary aspergillosis
    James L Kreindler
    Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Clin Invest 120:3242-54. 2010
    b>Allergic bronchopulmonary aspergillosis (ABPA) is caused by a dominant Th2 immune response to antigens derived from the opportunistic mold Aspergillus, most commonly Aspergillus fumigatus...
  53. ncbi Pathophysiology and immunology of allergic bronchopulmonary aspergillosis
    R B Moss
    Department of Pediatrics, Division of Pulmonary Medicine, Stanford University, Palo Alto, CA 94304 5786, USA
    Med Mycol 43:S203-6. 2005
    b>Allergic bronchopulmonary aspergillosis (ABPA) is a complication of persistent asthma and cystic fibrosis (CF), diseases in part characterized by excessive viscous mucus and compromised mucociliary clearance...
  54. ncbi Distribution and severity of bronchiectasis in allergic bronchopulmonary aspergillosis (ABPA)
    T A Mitchell
    National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA
    J Asthma 37:65-72. 2000
    ..distribution and severity of computed tomography (CT) and radiographic findings in patients with allergic bronchopulmonary aspergillosis (ABPA), probable ABPA, and asthmatic controls...
  55. ncbi Allergic bronchopulmonary aspergillosis complicating chronic obstructive pulmonary disease
    Ritesh Agarwal
    Mycoses 51:83-5. 2008
    b>Allergic bronchopulmonary aspergillosis (ABPA) is a well recognised entity which complicates the course of 1-2% of patients with asthma and 2-15% of cystic fibrosis...
  56. ncbi Allergic bronchopulmonary aspergillosis with middle lobe syndrome and allergic Aspergillus sinusitis
    A Shah
    Dept of Clinical Research, Vallabhbhai Patel Chest Institute, University of Delhi, India
    Eur Respir J 6:917-8. 1993
    ..Evaluation of the patient led to the diagnosis of concomitant allergic bronchopulmonary aspergillosis with allergic Aspergillus sinusitis, a rarely reported association.
  57. doi Aspergillus hypersensitivity and allergic bronchopulmonary aspergillosis in patients with acute severe asthma in a respiratory intensive care unit in North India
    Ritesh Agarwal
    Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India
    Mycoses 53:138-43. 2010
    The prevalence of allergic bronchopulmonary aspergillosis (ABPA) in chronic asthma has been reported in various studies...
  58. ncbi Effect of allergic bronchopulmonary aspergillosis on lung function in children with cystic fibrosis
    Richard Kraemer
    Division of Human Genetics, Department of Paediatrics, University of Bern, Inselspital, CH 3010 Bern, Switzerland
    Am J Respir Crit Care Med 174:1211-20. 2006
    ..The relationship between sensitization to Aspergillus fumigatus and progression of pulmonary function is not yet established in cystic fibrosis (CF)...
  59. ncbi Hyperdense mucoid impaction in allergic bronchopulmonary aspergillosis: CT appearance
    M Molinari
    Dipartimento di Scienze Cliniche, Sezione di Radiologia e UO di Scienze Radiologiche Università degli Studi di Parma, Italy
    Monaldi Arch Chest Dis 61:62-4. 2004
    b>Allergic bronchopulmonary aspergillosis is an immunologic pulmonary disease characterised by proximal bronchiectasis with normal peripheral branchings and mucoid impactions in patients with asthma...
  60. ncbi Allergic bronchopulmonary aspergillosis: new concepts of pathogenesis and treatment
    P A Wark
    Airways Research Centre, John Hunter Hospital, Newcastle, New South Wales, Australia
    Respirology 6:1-7. 2001
    b>Allergic bronchopulmonary aspergillosis (ABPA) is a condition that results from a hypersensitivity reaction to the fungus Aspergillus fumigatus...
  61. ncbi Pathogenesis of allergic bronchopulmonary aspergillosis and an evidence-based review of azoles in treatment
    Peter Wark
    Brooke Laboratories, Southampton University, MP 810 Tremona Road, Southampton, UK
    Respir Med 98:915-23. 2004
    b>Allergic bronchopulmonary aspergillosis (ABPA) is a complex condition that affects people with asthma and cystic fibrosis (CF)...
  62. ncbi Mucoid impaction: a localized form of allergic bronchopulmonary aspergillosis
    Blake G Scheer
    Division of Allergy and Immunology, Department of Internal Medicine, St Louis University School of Medicine, St Louis, Missouri, USA
    Allergy Asthma Proc 25:229-32. 2004
    ..There are striking similarities between patients with mucoid impaction and those with allergic bronchopulmonary aspergillosis (ABPA), often referred to as "mucoid microimpaction...
  63. ncbi A randomized trial of itraconazole in allergic bronchopulmonary aspergillosis
    D A Stevens
    Department of Medicine, Santa Clara Valley Medical Center, San Jose, Calif 95128 2699, USA
    N Engl J Med 342:756-62. 2000
    b>Allergic bronchopulmonary aspergillosis is a hypersensitivity disorder that can progress from an acute phase to chronic disease...
  64. ncbi Immunomodulatory role of C10 chemokine in a murine model of allergic bronchopulmonary aspergillosis
    C M Hogaboam
    Departments ofPathology and Internal Medicine, Division of Pulmonary and Critical Care, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 162:6071-9. 1999
    ..role of the chemokine C10 was explored in allergic airway responses during experimental allergic bronchopulmonary aspergillosis (ABPA). The intratracheal delivery of Asperigillus fumigatus Ag into A...
  65. ncbi Allergic bronchopulmonary aspergillosis' diagnosis remains a challenge
    Edilamara de Oliveira
    Division of Clinical Immunology and Allergy, University of Sao Paulo, R Prof Artur Ramos 178 ap 211A, 01454 904, Sao Paulo, SP, Brazil
    Respir Med 101:2352-7. 2007
    b>Allergic bronchopulmonary aspergillosis (ABPA) is a complex disease, triggered by a hypersensitivity reaction to the allergens of Aspergillus fumigatus, a fungus that opportunistically colonizes the lungs of patients with asthma...
  66. pmc Use of a synthetic peptide epitope of Asp f 1, a major allergen or antigen of Aspergillus fumigatus, for improved immunodiagnosis of allergic bronchopulmonary aspergillosis
    Taruna Madan
    Molecular Biochemistry and Diagnostics, Institute of Genomics and Integrative Biology, Mall Rd, Delhi, India
    Clin Diagn Lab Immunol 11:552-8. 2004
    b>Allergic bronchopulmonary aspergillosis (ABPA) is an immunologically complex allergic disorder caused by the fungal pathogen Aspergillus fumigatus...
  67. ncbi Allergic bronchopulmonary aspergillosis: an overview
    Dani S Zander
    Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston Medical School, Houston, TX 77030, USA
    Arch Pathol Lab Med 129:924-8. 2005
    This article provides an overview of the major pathologic manifestations of allergic bronchopulmonary aspergillosis; patient characteristics; clinical, radiographic, and laboratory features of the disease; and current knowledge about its ..
  68. ncbi Allergic bronchopulmonary aspergillosis
    I Tillie-Leblond
    Department of Pulmonology and Immuno Allergology, University Hospital of Lille, Lille, France
    Allergy 60:1004-13. 2005
    b>Allergic bronchopulmonary aspergillosis (ABPA) occurs in nonimmunocompromised patients and belongs to the hypersensitivity disorders induced by Aspergillus...
  69. ncbi Allergic bronchopulmonary aspergillosis: serologic update for 1995
    J Krasnick
    Department of Medicine, Northwestern University Medical School, Chicago, Illinois, USA
    J Clin Lab Immunol 46:137-42. 1995
    b>Allergic bronchopulmonary aspergillosis (ABPA) is a complex disease occurring in 1-2% of patients with asthma involving hypersensitivity to Aspergillus species...
  70. ncbi High-attenuation mucus in allergic bronchopulmonary aspergillosis: another cause of diffuse high-attenuation pulmonary abnormality
    Ritesh Agarwal
    Postgraduate Institute of Medical Education and Research Chandigarh, India 160012
    AJR Am J Roentgenol 186:904. 2006
  71. doi The effects of antifungal therapy on severe asthma with fungal sensitization and allergic bronchopulmonary aspergillosis
    Alessandro C Pasqualotto
    The University of Manchester, Manchester, UK
    Respirology 14:1121-7. 2009
    ..This study assessed the effect of antifungal therapy in patients with severe asthma with fungal sensitization (SAFS) and allergic bronchopulmonary aspergillosis (ABPA).
  72. doi Clinical significance of decline in serum IgE levels in allergic bronchopulmonary aspergillosis
    Ritesh Agarwal
    Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh, India
    Respir Med 104:204-10. 2010
    The total serum IgE level is a marker of immunological activity in allergic bronchopulmonary aspergillosis (ABPA), and a 35% decline beyond six weeks is traditionally taken as criteria for remission...
  73. ncbi An overview of allergic bronchopulmonary aspergillosis with some new insights
    Raymond G Slavin
    Division of Allergy and Immunology, Department of Internal Medicine, St Louis University School of Medicine, St Louis, Missouri 63104, USA
    Allergy Asthma Proc 25:395-9. 2004
    b>Allergic bronchopulmonary aspergillosis (ABPA) occurs as a complication of bronchial asthma or cystic fibrosis (CF)...
  74. ncbi IgE antibody to Aspergillus fumigatus recombinant allergens in cystic fibrosis patients with allergic bronchopulmonary aspergillosis
    A P Knutsen
    Divisions of Allergy and Immunology, Saint Louis University Health Sciences Center, St Louis, MO 63110, USA
    Allergy 59:198-203. 2004
    b>Allergic bronchopulmonary aspergillosis (ABPA) in cystic fibrosis (CF) is characterized by a heightened Th2 CD4+ T-cell response to Aspergillus fumigatus (Af) allergens and a hyper-immunoglobulin E (IgE) state compared with cystic ..
  75. ncbi Allergic bronchopulmonary aspergillosis in a 9-year-old boy
    Kiyotaka Suzuki
    Department of Pediatrics, Sinsiro City Hospital, Sinsiro City, Aichi 441 1387, Japan
    Eur J Pediatr 161:408-9. 2002
  76. ncbi Mild, moderate, and severe forms of allergic bronchopulmonary aspergillosis: a clinical and serologic evaluation
    Raj Kumar
    Department of Respiratory Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, 44 1 Probyn Road, Delhi 7, India
    Chest 124:890-2. 2003
    b>Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity disorder induced by Aspergillus species colonizing the bronchial tree...
  77. ncbi Intracutaneous tests with recombinant allergens in cystic fibrosis patients with allergic bronchopulmonary aspergillosis and Aspergillus allergy
    Wilfried H Nikolaizik
    Department of Paediatrics, University Hospital, Essen, Germany
    Am J Respir Crit Care Med 165:916-21. 2002
    b>Allergic bronchopulmonary aspergillosis (ABPA), an intensive inflammatory reaction to Aspergillus fumigatus, can cause irreversible lung damage in patients with cystic fibrosis (CF)...
  78. doi Steroid-sparing effect of omalizumab for allergic bronchopulmonary aspergillosis and cystic fibrosis
    Jacquelyn M Zirbes
    The Minnesota CF Center, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Pediatr Pulmonol 43:607-10. 2008
    b>Allergic bronchopulmonary aspergillosis (ABPA) is a complication commonly encountered in patients with CF that produces significant respiratory morbidity...
  79. pmc Successful treatment of allergic bronchopulmonary aspergillosis with recombinant anti-IgE antibody
    Cornelis K van der Ent
    Department of Pediatric Respiratory Diseases, University Medical Center Utrecht, KH 01 419 0, PO Box 85090, 3508 AB Utrecht, The Netherlands
    Thorax 62:276-7. 2007
    b>Allergic bronchopulmonary aspergillosis (ABPA) can cause severe worsening of the respiratory condition in patients with cystic fibrosis. Treatment can result in steroid dependency and serious adverse events...
  80. ncbi Surfactant protein D in serum from patients with allergic bronchopulmonary aspergillosis
    M Krane
    Children s Hospital, Ludwig Maximilians University of Munich, Munich, Germany
    Eur Respir J 22:592-5. 2003
    ..As the course of cystic fibrosis (CF) is often complicated by an allergic bronchopulmonary aspergillosis (ABPA), the authors hypothesised that SP-D may also be increased in serum during an ABPA, ..
  81. ncbi Cloning and expression of Aspergillus fumigatus allergen Asp f 16 mediating both humoral and cell-mediated immunity in allergic bronchopulmonary aspergillosis (ABPA)
    B Banerjee
    Department of Paediatrics, Allergy-Immunology Division, Medical College of Wisconsin, Milwaukee, WI 53295, USA
    Clin Exp Allergy 31:761-70. 2001
    ....
  82. ncbi Case quiz. Thoracic CT illustrating hyperdense bronchial mucous plugging: allergic bronchopulmonary aspergillosis
    Nishantha Karunaratne
    Department of Radiology, Concord Repatriation General Hospital, Hospital Road, Concord, New South Wales, Australia
    Australas Radiol 47:336-8. 2003
  83. ncbi Concomitant allergic bronchopulmonary aspergillosis and allergic Aspergillus sinusitis: a review of an uncommon association*
    A Shah
    Department of Respiratory Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India
    Clin Exp Allergy 31:1896-905. 2001
    Although thought to have common immunopathological processes, concomitant occurrence of allergic bronchopulmonary aspergillosis (ABPA) and allergic Aspergillus sinusitis (AAS) appears to be rarely reported as to date only five detailed ..
  84. doi Frequency of familial occurrence in 164 patients with allergic bronchopulmonary aspergillosis
    Ashok Shah
    Department of Respiratory Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India
    Ann Allergy Asthma Immunol 101:363-9. 2008
    Asthma is known to run in families. Allergic bronchopulmonary aspergillosis (ABPA) occurs predominantly in patients with asthma. However, there are only 6 reports of familial occurrence over a period of 35 years.
  85. ncbi Allergic bronchopulmonary aspergillosis, allergic fungal sinusitis, and hypersensitivity pneumonitis
    Paul A Greenberger
    Northwestern University Medical School, Chicago, Illinois, USA
    Clin Allergy Immunol 16:449-68. 2002
  86. ncbi Chest pain and pulmonary lesion in a child with asthma
    Christos Karatzios
    Division of Infectious Diseases, Department of Pediatrics, Montreal Children s Hospital, McGill University Health Center, Montreal, Quebec, Canada
    Pediatr Infect Dis J 24:1026, 1031. 2005
  87. doi Cauliflower mass obstructing the left main-stem bronchus
    Ali Hassoun
    Alabama Infectious Diseases Center, Huntsville, USA
    Clin Infect Dis 47:540-1, 585-6. 2008
  88. ncbi [Case of allergic bronchopulmonary aspergillosis successfully treated with itraconazole]
    Zen Isobe
    Department of Respiratory Medicine, Gunma University Graduate School of Medicine
    Arerugi 56:1390-6. 2007
    ..Aspergillus niger was detected in a bronchial lavage fluid. We therefore made a diagnosis of allergic bronchopulmonary aspergillosis (ABPA)...
  89. ncbi Identification of novel allergens of Aspergillus fumigatus using immunoproteomics approach
    P Gautam
    Molecular Biochemistry and Diagnostics Division, Institute of Genomics and Integrative Biology, Delhi, India
    Clin Exp Allergy 37:1239-49. 2007
    ..The characterization of specific IgE-inducing allergens in allergic aspergillosis patients is fundamental for clinical diagnosis and for immunotherapy...
  90. ncbi Nebulization of four commercially available amphotericin B formulations in persistently granulocytopenic rats with invasive pulmonary aspergillosis: evidence for long-term biological activity
    Elisabeth J Ruijgrok
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands
    J Pharm Pharmacol 57:1289-95. 2005
    ..All commercially available amphotericin B preparations could be nebulized efficiently and may be of value in the prophylactic treatment of invasive pulmonary aspergillosis...
  91. pmc The costimulatory molecules CD80, CD86 and OX40L are up-regulated in Aspergillus fumigatus sensitized mice
    C S Barrios
    Allergy Immunology Division, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, 53295, USA
    Clin Exp Immunol 142:242-50. 2005
    Aspergillus fumigatus (Af) is a fungus associated with allergic bronchopulmonary aspergillosis (ABPA) and other allergic diseases. Immune responses in these diseases are due to T and B cell responses...
  92. ncbi Asp f6, an Aspergillus allergen specifically recognized by IgE from patients with allergic bronchopulmonary aspergillosis, is differentially expressed during germination
    M Schwienbacher
    Max von Pettenkofer Institute, Ludwig Maximilans University, Munich, Germany
    Allergy 60:1430-5. 2005
    Aspergillus fumigatus is a pathogenic mould causing allergic and invasive respiratory diseases. Allergic bronchopulmonary Aspergillosis (ABPA) is a severe pulmonary complication resulting from hypersensitivity to A. fumigatus proteins...
  93. ncbi Who is the owner of this glove?
    Miriam Shteinshnaider
    Department of Internal Medicine F, Assaf Harofeh Medical Center, Zerifin, Israel
    Isr Med Assoc J 6:440-1. 2004
  94. ncbi Chronic necrotizing pulmonary aspergillosis successfully diagnosed, treated, and followed by ultrathin bronchoscope
    Yutaro Nakamura
    Mycoses 51:86-8. 2008
    ..The whitish intracavity lesion had prominently disappeared after 18 months of therapy. An ultrathin bronchoscope is useful for treating and assessing cavity lesions as well as establishing a diagnosis for CNPA patients...
  95. ncbi [Value of CT in allergic fungal sinusitis (AFS)]
    J J Braun
    Service ORL, Hopital de Hautepierre, Strasbourg Cedex, France
    J Radiol 89:480-6. 2008
    ..To assess the value of CT for diagnosis and follow-up of AFS. Evaluation of characteristic CT features of AFS...
  96. doi Native valve Aspergillus endocarditis complicating lung transplantation
    Toby M Maher
    Cardiothoracic Transplant Unit, Harefield Hospital, Harefield, Middlesex, UK
    J Heart Lung Transplant 27:910-3. 2008
    ..Aspergillus endocarditis should be considered a relapsing disease and survivors of the condition should receive ongoing anti-fungal therapy...
  97. ncbi Quantification of IgG antibodies to Aspergillus fumigatus and pigeon antigens by ImmunoCAP technology: an alternative to the precipitation technique?
    Erna Van Hoeyveld
    Department of Laboratory Medicine, Immunology, University Hospital Leuven, Belgium
    Clin Chem 52:1785-93. 2006
    ..We evaluated the ImmunoCAP technique for measurement of IgG specific to Aspergillus fumigatus and pigeon antigens...
  98. ncbi Aspergillus bronchitis in cystic fibrosis
    David Shoseyov
    Department of Pediatrics and CF Center, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel
    Chest 130:222-6. 2006
    ..A fumigatus may cause allergic bronchopulmonary aspergillosis (ABPA), a complex condition that leads to worsening of airway inflammation and progressive damage ..
  99. ncbi Specific IgE against recombinant allergens in allergic bronchopulmonary aspergillosis
    Pedro Giavina-Bianchi
    Am J Respir Crit Care Med 175:967; author reply 967-8. 2007
  100. ncbi Evaluation of peptone glucose fluconazole agar as a selective medium for rapid and enhanced isolation of Aspergillus fumigatus from the respiratory tract of bronchopulmonary aspergillosis patients colonized by Candida albicans
    H S Randhawa
    Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India
    Med Mycol 44:343-8. 2006
    ..fumigatus from sputum of patients clinically suspected of aspergillosis with C. albicans colonization in their respiratory tract...
  101. ncbi Efficacy of posaconazole and amphotericin B in experimental invasive pulmonary aspergillosis in dexamethasone immunosuppressed rats
    Andrew J Ullmann
    3rd Medical Department, Johannes Gutenberg University, Mainz, Germany
    J Antimicrob Chemother 60:1080-4. 2007
    ..Invasive pulmonary aspergillosis is associated with high mortality. To assess new antifungal therapy options, animal models have to be developed to assess, in an appropriate setting, the activity of new drugs...

Research Grants70

  1. IMMUNOPATHOGENESIS OF ALLERGIC ASPERGILLOSIS
    RAYMOND SLAVIN; Fiscal Year: 2001
    b>Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity lung disease resulting from a damaging immune response directed to the ubiquitous fungus, Aspergillus fumigatus (Af)...
  2. Host Factors in Fungal Allergy and Fibrosis
    Jay Kolls; Fiscal Year: 2007
    ..of patients with Cystic Fibrosis that have defined Aspergillus colonization with and without Allergic Bronchopulmonary Aspergillosis (ABPA) and a basic science project that uses a novel rodent model of immune tolerance or allergy ..
  3. IMMUNOPATHOGENESIS OF ALLERGIC ASPERGILLOSIS
    RAYMOND SLAVIN; Fiscal Year: 2003
    b>Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity lung disease resulting from a damaging immune response directed to the ubiquitous fungus, Aspergillus fumigatus (Af)...
  4. Characterization of Aspergillus fumigatus specific CD4 T cell responses.
    Eric G Pamer; Fiscal Year: 2010
    Aspergillus fumigatus is a spore forming mould that causes a range of human diseases, including allergic bronchopulmonary aspergillosis, an asthma-like disease, and invasive aspergillosis, a frequently fatal infection that occurs in ..
  5. Characterization of Aspergillus fumigatus specific CD4 T cell responses.
    Eric Pamer; Fiscal Year: 2007
    Aspergillus fumigatus is a spore forming mold that causes a range of human diseases, including allergic bronchopulmonary aspergillosis, an asthma-like disease, and invasive aspergillosis, a frequently fatal infection that occurs in ..
  6. Therapeutic Targeting of RANTES/CCL5 in Fungal Asthma.
    Cory Hogaboam; Fiscal Year: 2006
    ..These detailed studies are now possible because of the availability of novel chimeric protein that selectively targets RANTES/CCL5-responsive cells in the lung. ..
  7. IL-13 Fusion Cytotoxin as a Targeted Therapeutic for IIP
    Cory Hogaboam; Fiscal Year: 2006
    ..The proposed studies will critically evaluate a pathophysiologic paradigm in IIP that has not been thoroughly examined to date. ..
  8. Immune reconstitution to Aspergillus
    Kieren A Marr; Fiscal Year: 2010
    ..This information will be valuable for development of strategies to prevent and treat fungal infections in immunocompromised people. ..
  9. Immune reconstitution to Aspergillus
    Kieren Marr; Fiscal Year: 2009
    ..This information will be valuable for development of strategies to prevent and treat fungal infections in immunocompromised people. ..
  10. Pathobiology of C. neoformans in the Central Nervous System
    John R Perfect; Fiscal Year: 2010
    ....
  11. Pathobiology of C. neoformans in the Central Nervous System
    John Perfect; Fiscal Year: 2009
    ....
  12. Mechanisms of social-stress enhanced allergic airway response in a mouse model
    Angela Haczku; Fiscal Year: 2010
    ..2. Elucidation of the cellular and molecular pathways of the glucocorticoid action on immune cell function and epithelial cell SP-D production in stress-induced exacerbation of the inflammatory airway response. ..
  13. Pathobiology of C. neoformans in the Central Nervous System
    John R Perfect; Fiscal Year: 2010
    ....
  14. Regulation of Inflammation in Asthma by Fas Ligand
    Angela Haczku; Fiscal Year: 2009
    ..Finally, in order to help support the hypothesis that pro-apoptotic FasL activity characterized in human airway cells is truly physiologic, we will perform challenge studies in mice under FasL neutralizing conditions. ..
  15. CRYPTOCOCCUS NEOFORMANS--A MODEL FOR PATHOGENIC FUNGI
    John Perfect; Fiscal Year: 2003
    ..This program emphasizes a focus on a single pathogen with a basic but broad-spectrum and highly interactive genomic approach to scientific investigations which can be extrapolated to other fungi. ..
  16. GENETIC & MOLECULAR BIOLOGY OF VIRULENCE IN C NEOFORMANS
    John Perfect; Fiscal Year: 2004
    ..It is our hypothesis that beginning to understand the genetic regulation of C. neoformans during infection through this proposal will be a powerful tool to find targets to interrupt pathogenesis. ..
  17. Surfactant-Protein Innate Immunity in an Asthma Model
    Angela Haczku; Fiscal Year: 2007
    ..The potential opportunity to interfere with allergic sensitization by SP-D treatment bears high clinical significance. ..
  18. GENETIC/MOLECULAR BIOLOGY OF VIRULENCE IN C. NEOFORMANS
    John Perfect; Fiscal Year: 1993
    ....
  19. Pharmacodynamics in Antifungal Resistance
    David Andes; Fiscal Year: 2005
    ..The candidate's goal is to integrate knowledge of antifungal PD and the acquisition of approaches and skills in molecular biology through the completion of this grant. ..