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| coughSummarySummary: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs. Top Publications
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Publications
Managing acute cough in children: evidence-based guidelinesLaura K Kelley
Yale University School of Nursing, New Haven, CT, USA
Pediatr Nurs 33:515-24. 2007This article examines the evidence-based guidelines for diagnosis and treatment of acute cough in children. Cough is a common symptom in children and a frequent reason for consultation in primary care...
An algorithm for tuberculosis screening and diagnosis in people with HIVKevin P Cain
U S Centers for Disease Control and Prevention, Division of Tuberculosis Elimination, Atlanta, GA 30333, USA
N Engl J Med 362:707-16. 2010..No internationally accepted, evidence-based guideline addresses the optimal means of conducting such screening, although screening for chronic cough is common.
Detecting patients at a high risk of developing chronic obstructive pulmonary disease in general practice: cross sectional case finding studyC P van Schayck
Department of General Practice, Research Institute ExTra, University of Maastricht, Postbox 616, 6200 MD Maastricht, Netherlands
BMJ 324:1370. 2002..To investigate the effectiveness of case finding of patients at risk of developing chronic obstructive pulmonary disease, whether the method is suitable for use in general practice, how patients should be selected, and the time required...
The diagnosis and management of chronic coughA H Morice
Division of Academic Medicine, University of Hull, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire HU16 5JQ, UK
Eur Respir J 24:481-92. 2004
Chronic cough and phlegm in young adultsI Cerveri
Division of Respiratory Diseases, IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy
Eur Respir J 22:413-7. 2003The Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines underline that the presence of chronic cough and sputum production before airflow obstruction offers a unique opportunity to identify subjects at risk of ..
Barriers to accessing TB diagnosis for rural-to-urban migrants with chronic cough in Chongqing, China: a mixed methods studyQian Long
School of Public Health, Chongqing Medical University, No 1 Yixueyuan Road, Chongqing, PR China
BMC Health Serv Res 8:202. 2008..seeking behaviour of and health systems responses to migrants and permanent urban residents suffering from chronic cough, in order to identify the factors influencing delays for both groups in receiving a TB diagnosis in urban China.
Angiotensin-converting enzyme inhibitor associated cough: deceptive information from the Physicians' Desk ReferenceSripal Bangalore
Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Am J Med 123:1016-30. 2010Dry cough is a common, annoying adverse effect of all angiotensin-converting enzyme (ACE) inhibitors...
Complications of cough: ACCP evidence-based clinical practice guidelinesRichard S Irwin
University of Massachusetts Medical School, Room S6 842, 55 Lake Ave North, Worcester, MA 01655, USA
Chest 129:54S-58S. 2006..To review the spectrum and frequency of complications associated with coughing...
Prevalence of chronic obstructive pulmonary disease in China: a large, population-based surveyNanshan Zhong
Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical College, 151 Yanjiang Road, Guangzhou, Guangdong 510120, China
Am J Respir Crit Care Med 176:753-60. 2007..The prevalence of chronic obstructive pulmonary disease (COPD) in China is largely unknown...
Sensitivity and specificity of fluorescence microscopy for diagnosing pulmonary tuberculosis in a high HIV prevalence settingA Cattamanchi
Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, California, USA
Int J Tuberc Lung Dis 13:1130-6. 2009..Mulago Hospital, Kampala, Uganda...
Variation in antibiotic prescribing and its impact on recovery in patients with acute cough in primary care: prospective study in 13 countriesC C Butler
Department of Primary Care and Public Health, School of Medicine, Cardiff University, Cardiff CF14 4XN, Wales
BMJ 338:b2242. 2009To describe variation in antibiotic prescribing for acute cough in contrasting European settings and the impact on recovery.
High frequency of chronic cough and sputum production with lowered exercise capacity in young smokersAnna Hamari
Department of Medicine, Pulmonary Division, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Ann Med 42:512-20. 2010..The aim was to evaluate how cigarette smoking is associated with respiratory symptoms, fitness, and anthropometric measures in young smokers...
Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parentsIan M Paul
Department of Pediatrics, Division of General Pediatrics, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033 0850, USA
Pediatrics 114:e85-90. 2004..medications dextromethorphan and diphenhydramine are superior to placebo for the treatment of nocturnal cough and sleep difficulty associated with upper respiratory infections and to determine whether parents have improved ..
Suppression of cough during emergence from general anesthesia: laryngotracheal lidocaine through a modified endotracheal tubeC A Diachun
Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305 5640, USA
J Clin Anesth 13:447-51. 2001..To ascertain if coughing during emergence from general anesthesia can be suppressed with a modified endotracheal tube...
Angiotensin-converting enzyme-related cough among Chinese-AmericansDaniel S Tseng
Department of Medicine, Kaiser Permanente of Northern California, Santa Clara, USA
Am J Med 123:183.e11-5. 2010..We investigated the perception that Chinese-Americans may have a higher incidence of chronic cough from angiotensin-converting enzyme inhibitors.
Increased tachykinin levels in induced sputum from asthmatic and cough patients with acid refluxRobert N Patterson
Department of Medicine, Queen s University Belfast, and Regional Respiratory Centre, Belfast City Hospital, Grosvenor Road, Belfast BT12 6BJ, UK
Thorax 62:491-5. 2007Acid reflux may aggravate airway disease including asthma and chronic cough. One postulated mechanism concerns a vagally-mediated oesophageal-tracheobronchial reflex with airway sensory nerve activation and tachykinin release.
Chronic cough and phlegm in young adults: should we worry?Jørgen Vestbo
Am J Respir Crit Care Med 175:2-3. 2007
Molecular characterization and distinguishing features of a novel human rhinovirus (HRV) C, HRVC-QCE, detected in children with fever, cough and wheeze during 2003K E Arden
Sir Albert Sakzewski Virus Research Centre, Queensland Children s Medical Research Institute, Royal Children s Hospital, Queensland, Australia
J Clin Virol 47:219-23. 2010....
Desensitization of the cough reflex by exercise and voluntary isocapnic hyperpneaFederico Lavorini
Department of Internal Medicine, Respiratory Medicine and Cell Therapy, University of Florence, Florence, Italy
J Appl Physiol 108:1061-8. 2010..The threshold for the cough reflex induced by inhalation of increasing nebulizer outputs of ultrasonically nebulized distilled water (fog), an ..
Chronic cough: eosinophilic bronchitis without asthmaP G Gibson
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Lancet 1:1346-8. 1989Sputum cell-counts were studied in 7 non-smokers with corticosteroid-responsive chronic cough productive of sputum and 8 smokers with a clinical diagnosis of chronic bronchitis, all of whom had normal lung function tests and methacholine ..
Systematic review and meta-analysis of randomised controlled trials of gastro-oesophageal reflux interventions for chronic cough associated with gastro-oesophageal refluxA B Chang
Department of Respiratory Medicine, Royal Children s Hospital, Herston, Brisbane, QLD 4029, Australia
BMJ 332:11-7. 2006To evaluate the efficacy of treatment for gastro-oesophageal reflux disease (GORD) on chronic cough in children and adults without an underlying respiratory disease.
Controlled comparison between betamethasone gel and lidocaine jelly applied over tracheal tube to reduce postoperative sore throat, cough, and hoarseness of voiceP A Sumathi
Department of Anaesthesiology, Kasturba Medical College, Manipal 576104, India
Br J Anaesth 100:215-8. 2008Postoperative sore throat, cough, and hoarseness of voice though minor sequelae after general tracheal anaesthesia can be distressing to the patient.
The size and concentration of droplets generated by coughing in human subjectsShinhao Yang
Department of Environmental and Occupational Health, Toko University, Taiwan, Republic of China
J Aerosol Med 20:484-94. 2007..Comparison of the droplet concentrations for subjects in different age groups demonstrated that subjects in the 30-50-year age group have the largest droplet concentrations...
Clinical signs and symptoms predicting influenza infectionA S Monto
University of Michigan, 3080 SPH 1, 109 Observatory St, Ann Arbor, MI 48109 2029, USA
Arch Intern Med 160:3243-7. 2000..In clinical practice, antiviral use has rarely been guided by antecedent laboratory diagnosis. Defined clinical predictors of an influenza infection can help guide timely therapy and avoid unnecessary antibiotic use...
Development and validation of a clinical prediction rule for angiotensin-converting enzyme inhibitor-induced coughTakeshi Morimoto
Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
J Gen Intern Med 19:684-91. 2004..enzyme inhibitors are effective for many cardiovascular diseases and are widely prescribed, but cough sometimes necessitates their withdrawal...
Anatomy and neurophysiology of the cough reflex: ACCP evidence-based clinical practice guidelinesBrendan J Canning
Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Chest 129:33S-47S. 2006To describe the anatomy and neurophysiology of the cough reflex.
Weakly acidic reflux in patients with chronic unexplained cough during 24 hour pressure, pH, and impedance monitoringD Sifrim
Faculty of Medicine, KU Leuven, Lab G I Physiopathology, O and N Gasthuisberg, 7th Floor, Herestraat 49, 3000, Leuven, Belgium
Gut 54:449-54. 2005Acid gastro-oesophageal reflux is one of the most important causes of chronic cough. The response to acid suppression in these patients is not as good as in patients with heartburn but improvement with antireflux surgery has been ..
Incidence of chronic obstructive pulmonary disease in a cohort of young adults according to the presence of chronic cough and phlegmRoberto de Marco
Sezione di Epidemiologia and Statistica Medica, Dipartimento di Medicina e Sanita Pubblica, Universita degli Studi di Verona, c o Istituti Biologici II, Strada Le Grazie 8 37134, Verona, Italy
Am J Respir Crit Care Med 175:32-9. 2007The few prospective studies aimed at assessing the incidence of chronic obstructive pulmonary disease (COPD) in relation to the presence of chronic cough/phlegm have produced contrasting results.
Identification of the tracheal and laryngeal afferent neurones mediating cough in anaesthetized guinea-pigsBrendan J Canning
Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
J Physiol 557:543-58. 2004We have identified the tracheal and laryngeal afferent nerves regulating cough in anaesthetized guinea-pigs...
Cough and sputum production are associated with frequent exacerbations and hospitalizations in COPD subjectsPierre Regis Burgel
Service de Pneumologie, Hopital Cochin, Assistance Publique Hopitaux de Paris, 27 rue du Faubourg St Jacques, Paris Cedex 14, France
Chest 135:975-82. 2009Epidemiologic studies indicate that chronic cough and sputum production are associated with increased mortality and disease progression in COPD subjects...
Medullary respiratory neurones and control of laryngeal motoneurones during fictive eupnoea and cough in the catD M Baekey
Department of Physiology and Biophysics, University of South Florida Health Sciences Center, 12901 Bruce B. Downs Boulevard, Tampa, FL 33612-4799, USA
J Physiol 534:565-81. 2001..2. Data were obtained from 28 mid-collicular decerebrated, artificially ventilated cats. Cough-like motor patterns (fictive cough) in phrenic, lumbar and recurrent laryngeal nerves were elicited by mechanical ..
Intravenous dexamethasone pretreatment reduces fentanyl-induced coughJui An Lin
Department of Anesthesiology, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
J Formos Med Assoc 106:649-55. 2007Fentanyl is regularly used in clinical anesthesia practice but fentanyl-induced cough (FIC) will sometimes bother anesthesiologists. This study was designed to examine the effect of intravenous (IV) dexamethasone (DEX) on FIC.
Cough suppression during flexible bronchoscopy using combined sedation with midazolam and hydrocodone: a randomised, double blind, placebo controlled trialD Stolz
Division of Respiratory Medicine and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland
Thorax 59:773-6. 2004..A randomised, placebo controlled, double blind study was undertaken to determine whether hydrocodone in combination with midazolan improves cough suppression during FB without increasing the risk of desaturation.
Exhaled droplets due to talking and coughingXiaojian Xie
Department of Mechanical Engineering, University of Hong Kong, Pokfulam Road, Hong Kong SAR, People s Republic of China
J R Soc Interface 6:S703-14. 2009..Smaller droplets were also detected by the aerosol spectrometer. More droplets seemed to be generated when a food dye was used...
World Trade Center cough--a lingering legacy and a cautionary talePaul D Scanlon
Mayo Clinic, Rochester, MN 55905
N Engl J Med 347:840-2. 2002
A schlieren optical study of the human cough with and without wearing masks for aerosol infection controlJulian W Tang
Department of Laboratory Medicine, National University of Singapore, Singapore
J R Soc Interface 6:S727-36. 2009..Further, a high-speed schlieren video of a single cough is analysed by a computerized method of tracking individual turbulent eddies, demonstrating the non-intrusive ..
Cough reflex in allergic dogsAileen House
Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
Eur J Pharmacol 492:251-8. 2004This study investigated the effects of antigen challenge on the cough reflex in dogs that were neonatally sensitized to ragweed...
Cough receptor sensitivity to capsaicin does not change after allergen bronchoprovocation in allergic asthmaH Minoguchi
First Department of Internal Medicine, Showa University, Tokyo, Japan
Thorax 58:19-22. 2003The relationship between cough receptor sensitivity and eosinophilic inflammation of the airway in patients with asthma remains unclear.
Excess mortality and tuberculosis among individuals with prolonged cough: a population-based study from VietnamN P Hoa
Department of Public Health Sciences, Division of International Health (IHCAR, Karolinska Institutet, Stockholm, Sweden
Int J Tuberc Lung Dis 10:851-6. 2006..smear-positive tuberculosis (TB) and mortality rates between the general population and individuals with prolonged cough. DESIGN: A cohort study of 559 prolonged cough cases in a total population of 35,832, observed over 2.5 years...
Effect of acute unilateral middle cerebral artery infarcts on voluntary cough and the laryngeal cough reflexRobert E Stephens
Department of Anatomy, University of Health Sciences, Kansas City, Missouri 64106-1453, USA
Am J Phys Med Rehabil 82:379-83. 2003..unilateral middle cerebral artery (MCA) infarctions in right-handed subjects on their ability to elicit voluntary cough (VC), and separately to assess the laryngeal cough reflex using the reflex cough test...
Assessment of the cough reflex after propofol anaesthesia for colonoscopyJ Guglielminotti
Service d Anesthésiologie et de Réanimation Chirurgicale, Hopital Bichat, Assistance Publique, Hopitaux de Paris, 46 rue Henri Huchard, F 75018 Paris, France
Br J Anaesth 95:406-9. 2005Dysfunction of the cough reflex as a result of the lingering effects of anaesthetics may lead to aspiration pneumonia or retained secretions after general anaesthesia...
A 14-yr-old male with dyspnoea, productive cough and chest painG A Rossi
Dept of Pulmonology, G. Gaslini Institute, Genoa, Italy
Eur Respir J 22:387-91. 2003
Flow dynamics and characterization of a coughJ K Gupta
National Air Transportation Center of Excellence for Research in the Intermodal Transport Environment RITE, School of Mechanical Engineering, Purdue University, West Lafayette, IN 47906 2088, USA
Indoor Air 19:517-25. 2009Airborne disease transmission has always been a topic of wide interests in various fields for decades. Cough is found to be one of the prime sources of airborne diseases as it has high velocity and large quantity of droplets...
Idiopathic chronic cough: association with organ specific autoimmune disease and bronchoalveolar lymphocytosisS S Birring
Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK
Thorax 58:1066-70. 2003We have recently reported a strong association between organ specific autoimmune disease and idiopathic chronic cough and have suggested that cough may be caused by airway inflammation secondary to aberrant homing of activated ..
Reducing venipuncture pain by a cough trick: a randomized crossover volunteer studyTaras I Usichenko
Department of Anesthesiology and Intensive Care Medicine, Ernst Moritz Arndt University, Greifswald, Germany
Anesth Analg 98:343-5, table of contents. 2004We tested the effectiveness of the cough trick (CT) as a method of pain relief during peripheral venipuncture (VP) in a crossover study...
Vagal afferent nerves regulating the cough reflexBrendan J Canning
Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Respir Physiol Neurobiol 152:223-42. 2006..All afferent nerve subtypes innervating the airways can modulate the cough reflex...
Pharmacology of cough and cold medicinesTeri Woo
University of Portland, School of Nursing, Kaiser Permanente, OR, USA
J Pediatr Health Care 22:73-9; quiz 80-2. 2008
Characterization of increased cough sensitivity after antigen challenge in guinea pigsQ Liu
The Third Department of Internal Medicine, Kanazawa University School of Medicine, 13-1 Takara-machi, Kanazawa 920-8641, Japan
Clin Exp Allergy 31:474-84. 2001Increased sensitivity of cough reflex is a fundamental feature of bronchodilator resistant non-productive cough associated with eosinophilic tracheobronchitis...
A young male with chest pain, cough and feverG E Kapotsis
Dept of Critical Care and Pulmonary Services, 45-47 Ipsilantou Street, Evangelismos Hospital, GR 10675, Athens, Greece
Eur Respir J 24:506-9. 2004
Irritant-induced chronic cough: irritant-induced TRPpathyStuart M Brooks
Colleges of Public Health, University of South Florida, Tampa, FL 33612, USA
Lung 186:S88-93. 2008This article expands the author's presentation at the First American Cough Conference in New York City, June 8-9, 2007. The results of a scientific literature search and application of personal research findings are included...
Mechanisms of pelvic floor muscle function and the effect on the urethra during a coughRuth C Lovegrove Jones
Palo Alto Veterans Administration Medical Centre and Department of Urology, Stanford University School of Medicine, Stanford, CA 94304 1290, USA
Eur Urol 57:1101-10. 2010..Current measurement tools have difficulty identifying the automatic physiologic processes maintaining continence, and many questions still remain about pelvic floor muscle (PFM) function during automatic events...
Fog-induced cough with impaired respiratory sensation in congenital central hypoventilation syndromeFederico Lavorini
Dipartimento di Area Critica Medico Chirurgica, Sezione di Medicina Respiratoria, Universita degli Studi di Firenze, Viale G B Morgagni, 85 50134 Florence, Italy
Am J Respir Crit Care Med 176:825-32. 2007..Little is known regarding cough in CCHS...
Supramedullary influences on coughJohn Widdicombe
University of London, 116 Pepys Road, London SW20 8NY, UK
Respir Physiol Neurobiol 152:320-8. 2006The evidence for supramedullary influences on cough is largely indirect. Cough can be voluntarily induced or inhibited, functions usually thought to reside in the cerebral cortex...
Central regulation of the cough reflex: therapeutic implicationsBrendan J Canning
Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
Pulm Pharmacol Ther 22:75-81. 2009..Both of these classes of drugs act centrally to prevent cough. A brief review of what is known about the central encoding of cough is presented, as are the advantages of ..
Bordetella pertussis and chronic cough in adultsN H Birkebaek
Department of Pediatrics, Skejby Hospital, University of Arhus, Brendstrupgårdsvej, Denmark
Clin Infect Dis 29:1239-42. 1999To evaluate Bordetella pertussis as a cause of persistent cough in adults, we examined 201 patients who had a cough for 2-12 weeks and no pulmonary disease...
Differences between zofenopril and ramipril, two ACE inhibitors, on cough induced by citric acid in guinea pigs: role of bradykinin and PGE2Cecilia Cialdai
Department of Pharmacology, Menarini Ricerche S p A, via Rismondo 12A, 50131, Florence, Italy
Naunyn Schmiedebergs Arch Pharmacol 382:455-61. 2010Dry and persistent cough is one of the commonest side effects experienced by patients treated with angiotensin-converting enzyme (ACE) inhibitors for the therapy of hypertension and congestive heart failure...
Acid-sensitive vagal sensory pathways and coughMarian Kollarik
The Johns Hopkins School of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
Pulm Pharmacol Ther 20:402-11. 2007Acid is an important mediator in the pathogenesis of cough. Inhalation of exogenous acid triggers cough and endogenous acid may contribute to cough in respiratory diseases...
Pharmacogenetic predictors of angiotensin-converting enzyme inhibitor-induced cough: the role of ACE, ABO, and BDKRB2 genesSergi Mas
Department of Anatomic Pathology, University of Barcelona, Spain
Pharmacogenet Genomics 21:531-8. 2011Dry cough is the most common reason for stopping angiotensin-converting enzyme inhibitors (ACEi) therapy. The role of ACE in the metabolism of bradykinin has been proposed as a pathogenic mechanism...
Health seeking behaviour, health system experience and tuberculosis case finding in Gambians with coughYaya Kasse
Tuberculosis Division, Medical Research Council Laboratories, Banjul, The Gambia
BMC Public Health 6:143. 2006..We aimed to study health-seeking behaviour and experience of those with cough in The Gambia and to identify whether they had tuberculosis.
Comparison of PCR for sputum samples obtained by induced cough and serological tests for diagnosis of Mycoplasma pneumoniae infection in childrenTsutomu Yamazaki
Department of Pediatrics, Saitama Medical School, Morohongo 38, Moroyama, Iruma, 350 0495 Japan
Clin Vaccine Immunol 13:708-10. 2006..The sensitivity and specificity of PA were 80.3% and 92.3% at a titer of 1:80. ELISA was found to be less sensitive than PA...
Clinical history in gastroesophageal coughCaroline F Everett
Academic Department of Medicine, Institute of Postgraduate Medicine, University of Hull, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire, UK
Respir Med 101:345-8. 2007Gastroesophageal disease, a common cause of chronic cough, is often poorly recognised. We reviewed the presenting history of 47 chronic cough patients who had been proven to have gastroesophageal disease by oesophageal function testing...
The natural history of acute cough in children aged 0 to 4 years in primary care: a systematic reviewAlastair D Hay
Department of General Practice and Primary Health Care, University of Leicester
Br J Gen Pract 52:401-9. 2002Professional and parental uncertainty regarding the natural history of cough and respiratory tract infection (R77) in pre-school children may in part be responsible for the high consultation, reconsultation, and antibiotic prescribing ..
The cough reflex in animals: relevance to human cough researchBrendan J Canning
Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
Lung 186:S23-8. 2008All mammalian species studied cough or display some similar respiratory reflex upon aerosol challenge with tussigenic stimuli such as citric acid or capsaicin...
The clinical utility of flexible bronchoscopy in the evaluation of chronic coughTerrance W Barnes
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
Chest 126:268-72. 2004To assess the clinical utility of flexible bronchoscopy (FB) in the evaluation of patients with chronic cough and normal or nonlocalizing chest radiographic findings.
Effective antitussives for the cough patient: an unmet needK F Chung
National Heart and Lung Institute, Imperial College London and Royal Brompton and Harefield NHS Trust, London SW3, UK
Pulm Pharmacol Ther 20:438-45. 2007Chronic cough is a prevalent symptom in the community but it is likely that only a small fraction of chronic coughers seek medical attention...
The role of pH monitoring in extraesophageal gastroesophageal reflux diseaseTasneem Ahmed
Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, A30, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Gastrointest Endosc Clin N Am 15:319-31. 2005..reflux disease (GERD) is linked to several extraesophageal disease states including laryngitis, asthma, chronic cough, and noncardiac chest pain (NCCP)...
Questionnaire survey of chronic cough in asthmatic patientsWei-Li Wei
Department of Respiratory Medicine, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China
Chin Med J (Engl) 117:1726-8. 2004
Development of a questionnaire weighted scoring system to target diagnostic examinations for asthma in adults: a modelling studySybil Hirsch
General Practice Research Unit, North West Lung Research Centre, Wythenshawe Hospital, Manchester, M23 9LT, UK
BMC Fam Pract 5:30. 2004..This study has therefore developed and tested a weighted scoring system that prioritises those most urgently in need, based on their questionnaire responses...
Chronic cough. Three most common causesPieter Jugovic
Primary Care Lung Clinic, 1670 Dufferin St, Suite 107, Toronto, ON M6H 3M2
Can Fam Physician 48:1311-6. 2002OBJECTIVE: To describe an approach to diagnosis and treatment of patients with chronic cough. QUALIITY OF EVIDENCE: MEDLINE was search for reports of studies comducted between 1970 and 2000 on chronic cough and its epidemiology, natural ..
Cough and glottic-stop reflex sensitivity in health and diseaseBenjamin Prudon
MB ChB, Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester, LE3 9QP UK
Chest 127:550-7. 2005STUDY OBJECTIVES: Little is known about the normal ranges and repeatability of cough reflex sensitivity measurements, or the relationship of cough reflex sensitivity to other upper airway reflexes in subjects with chronic dry cough...
[Topic complex V: Extra-esophageal manifestations]G Micklefield
Z Gastroenterol 43:182-4. 2005
Serum and sputum neurotrophin levels in chronic persistent coughR Chaudhuri
Departments of Respiratory Medicine, University of Glasgow and Western Infirmary, Glasgow, UK
Clin Exp Allergy 35:949-53. 2005..Serum and induced sputum NT levels are increased in asthma and in cough because of idiopathic pulmonary fibrosis, respectively...
Pathophysiology and therapy of chronic coughK F Chung
Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College, London, London, UK
Minerva Med 96:29-40. 2005b>Cough is an essential protective mechanism for the airways and lungs...
The spectrum of pulmonary symptoms due to gastroesophageal refluxStephen J Sontag
Veterans Affairs Hospital, Building 1, Room B321 151B3 Hines, IL 60141, USA
Thorac Surg Clin 15:353-68. 2005..It is not unreasonable to urge patients to alter their lifestyle: the huge volume, calorie-dense, high-fat meals eaten before bedtime are not likely to prevent GER or add to their life expectancy...
Agreement between responses to a standardized asthma questionnaire and a questionnaire following a demonstration of asthma symptoms in adultsNigel C Smeeton
Department of Public Health Sciences, King s College London, Capital House 5th Floor, 42 Weston Street, London SE1 2QD, United Kingdom
Am J Epidemiol 163:384-91. 2006..The symptoms were wheeze, waking at night with breathlessness, breathlessness following exercise, and waking with cough. The kappa statistic did not exceed 0...
[Chronic cough: practical aspects]Laurent Favre
Service de Pneumologie, CHUV, 10 11 Lausanne
Rev Med Suisse 2:2605-9. 2006A cough is defined as chronic, if it exceeds 8 weeks in length. Post-nasal drip (PND), bronchial asthma and gastro-esophageal reflux (GERD) must be systematically investigated, as these account for 90 percent of chronic cough cases...
Understanding chronic coughSusan Simmons Holcomb
Olathe Medical Services, Inc, Olathe, KS, USA
Nurse Pract 32:9-11. 2007
[Diagnosis and treatment of chronic cough -an overview]Akio Niimi
Dept of Respiratory Medicine, Kyoto University
Arerugi 56:85-8. 2007
Airway wall thickening in patients with cough variant asthma and nonasthmatic chronic coughHisako Matsumoto
Department of Respiratory Medicine, Kyoto University, Sakyo ku, Kyoto, 606 8507, Japan
Chest 131:1042-9. 2007Chronic cough, which may be of asthmatic or nonasthmatic origin, is an important clinical issue...
QUOTAC: QUestionnaire On day and night Time respiratory symptoms in Asthmatic Children -- a validity studyB van Zaane
Department of Pediatric Pulmonology Emma Children s Hospital AMC, Amsterdam
J Asthma 44:107-11. 2007..However, cut-off scores for mild, moderate, or severe asthma should be investigated in further research...
Salivary cotinine, doctor-diagnosed asthma and respiratory symptoms in primary schoolchildrenAli Delpisheh
Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
Matern Child Health J 12:188-93. 2008..3% a history of hospital admission for respiratory illnesses. The symptom triad of cough, wheeze and breathlessness (C+W+B+) occurred in 12.6% of children. The geometric mean cotinine level was 0...
Not quite asthma: differential diagnosis of dyspnea, cough, and wheezingMichael C Slaughter
Allergy and Asthma Treatment Center, Queensbury, New York 12804, USA
Allergy Asthma Proc 28:271-81. 2007Every allergist will eventually encounter a patient who has a persistent cough, dyspnea, and wheezing, but few atopic references, and a limited response to conventional treatment...
[Cough in the child and the adult (with treatment)]Elisabeth Bonnemaison
, , CHRU de Tours, 37044 Tours cedex 9
Rev Prat 57:1115-20; quiz 1128. 2007
Pseudo-asthma revisitedRan D Anbar
Pediatrics 121:221; author reply 221-2. 2008
Pseudo-asthma: when cough, wheezing, and dyspnea are not asthmaMiles Weinberger
Department of Pediatrics, University of Iowa Hospital, 200 Hawkins Dr, Iowa City, IA 52242, USA
Pediatrics 120:855-64. 2007Although asthma is the most common cause of cough, wheeze, and dyspnea in children and adults, asthma is often attributed inappropriately to symptoms from other causes...
Improvement of asthma therapy by a novel formoterol multidose dry powder inhalerManfred Moeller
Practice for Pneumology, Internal Medicine, Allergology, Hanau, Germany
Arzneimittelforschung 58:168-73. 2008..The severity of cough, wheezing, diurnal dyspnea, nocturnal dyspnea and dyspnea on physical effort were assessed on a four-point scale, ..
Chronic respiratory symptoms in Croatian Adriatic island metapopulationsEugenija Zuskin
Department of Environmental and Occupational Health, Andrija Stampar School of Public Health, Zagreb University School of Medicine, Zagreb, Croatia
Croat Med J 47:627-34. 2006..To investigate the prevalence of chronic respiratory symptoms in 9 metapopulations on Adriatic islands in Croatia, and the relationship between respiratory symptoms and individual genetic background...
[Asthma-like conditions still not completely mapped. Capsaicin may give a differential diagnosis--but is not yet ready for clinical use]Lennart Hansson
Universitetssjukhuset i Lund
Lakartidningen 102:3867-8. 2005
[Asthma--a disease difficult to define. Patients can receive correct treatment by means of differential diagnosis criteria]Olle Lowhagen
Sahlgrenska Universitetssjukhuset Sahlgrenska, Goteborg, Sweden
Lakartidningen 102:3872-3, 3875-8. 2005..Sensory hyperreactivity may also be present in patients with "classical" asthma sometimes explaining the lack of effect of asthma medication...
Overview of common causes of chronic cough: ACCP evidence-based clinical practice guidelinesMelvin R Pratter
Robert Wood Johnson School of Medicine at Camden, Suite 312, 3 Cooper Plaza, Camden, NJ 08103, USA
Chest 129:59S-62S. 2006To review the literature on the most common causes of chronic cough.
12-year change in prevalence of respiratory symptoms in elderly Chinese living in Hong KongFanny W S Ko
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, New Territories, Hong Kong
Respir Med 100:1598-607. 2006..7% in 1991 and 7.7% in 2003). The prevalence of respiratory symptoms has increased over the past 12 years and this may be related to environmental factors especially increasing air pollution in Hong Kong...
Household environmental tobacco smoke exposure, respiratory symptoms and asthma in non-smoker adults: a multicentric population study from IndiaD Gupta
Postgraduate Institute of Medical Education and Research, Chandigarh, India
Indian J Chest Dis Allied Sci 48:31-6. 2006..tobacco smoke exposure was also significantly associated with prevalence of respiratory symptoms such as wheezing, cough and breathlessness...
Association between reported exposure to road traffic and respiratory symptoms in children: evidence of biasClaudia E Kuehni
Swiss Paediatric Respiratory Research Group, Department of Social and Preventive Medicine, University of Berne, Switzerland
Int J Epidemiol 35:779-86. 2006..We estimated the association between self-reported exposure to road traffic and respiratory symptoms in preschool children, and investigated whether the effect could have been caused by reporting bias...
[Airways acidification and pathogenesis of asthma]Metka Kodric
Struttura Complessa Pneumologia, Ospedale di Cattinara, Azienda Ospedaliero Universitaria Ospedali Riuniti, Trieste
Recenti Prog Med 99:210-4. 2008..The effects of acidification may cause symptoms as cough, dyspnoea, wheezing and may be related to gastroesophageal reflux-induced asthma, inhaled acids (pollution, fog, ..
Characterisation of the onset and presenting clinical features of adult bronchiectasisPaul T King
Department of Respiratory Medicine, Monash Medical Centre, Monash University, Melbourne, Australia
Respir Med 100:2183-9. 2006..Therefore a study was performed on a large cohort of adult patients presenting to Monash Medical Centre (MMC) to survey the course of their disease up to the time of diagnosis...
The absence of dyspnoea, cough and wheezing: a reason for undiagnosed airflow obstruction?Gérald d'Andiran
Hopital Cantonal Universitaire de Geneve, Geneva, Switzerland
Swiss Med Wkly 136:425-33. 2006..In a pulmonologist's private practice, the objectives were to detect UDAO in the absence of dyspnoea, cough and wheezing, to improve its screening following other anamnestic data, and to separate UDAO patients into "..
Does idiopathic cough exist?Lorcan P A McGarvey
Department of Medicine, The Queen s University of Belfast, Belfast, Northern Ireland, UK
Lung 186:S78-81. 2008..protocol involving diagnostic testing and trials of empirical therapy, there may be no obvious cause for a chronic cough in up to 42% of cases referred for specialist evaluation...
Quality of Life and clinical symptoms in asthmatic subjectsG Riccioni
Respiratory Pathophysiology Center, Department of Internal Medicine and Aging, University of Chieti, Chieti, Italy
J Asthma 41:85-9. 2004..Quality of Life (QoL) measurements are more responsive to clinically significant changes than conventional clinical measures. The aim of the study was to evaluate the relationship between asthma symptoms and QoL in asthmatic patients...
Clinical diagnosis of current asthma: predictive value of respiratory symptoms in the SAPALDIA study. Swiss Study on Air Pollution and Lung Diseases in AdultsD Sistek
Centre Valaisan de Pneumologie Montana, Suisse
Eur Respir J 17:214-9. 2001..Simple symptoms such as wheezing with dyspnoea, chronic phlegm or chronic cough had specificity greater than 95%...
[Sensitivity and specificity of a questionnaire about respiratory symptoms similar to asthma]L G Ochoa Jiménez
Departamento de neumologia, Hospital General Dr Gaudencio Gonzalez Garza, Centro Medico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico, DF
Rev Alerg Mex 48:9-14. 2001..Questionnaires are an epidemiological instrument to detect patients with asthma...
Lung function and respiratory health in adolescents of very low birth weightD Anand
FSID Unit of Perinatal and Paediatric Epidemiology, Department of Public Health, Liverpool, UK
Arch Dis Child 88:135-8. 2003....
Research Grants
- Quercetin and Innate Immune Responses in COPDUmadevi Sajjan; Fiscal Year: 2009..kaempferol) has been positively associated with pulmonary function (FEV1) and inversely associated with chronic cough and breathlessness in Dutch COPD patients (6)...
- Quercetin and Innate Immune Responses in COPDUMADEVI SIVANAPPA SAJJAN; Fiscal Year: 2010..kaempferol) has been positively associated with pulmonary function (FEV1) and inversely associated with chronic cough and breathlessness in Dutch COPD patients (6)...
- ASTHMA AND ALLERGIC DISEASE CENTERThomas Platts Mills; Fiscal Year: 2007..Project 4: Mechanisms of pH deviation in asthma and chronic cough: Using new methods of measuring exhaled breath pH, the studies will focus on distinguishing between patients with ..
- RECOMBINANT & LIVE ORAL SALMONELLA TYPHI HYBRID VACCINESMyron Levine; Fiscal Year: 2007..The clinical syndrome began with fever, dry cough, myalgia and sore throat and progressed to atypical pneumonia...
- SCCOR in Host Factors in Chronic Lung DiseaseRichard Boucher; Fiscal Year: 2007..Sheehan); Core D, Diagnostic Molecular Microbiology Core (M. Wolfgang); and Core E, Mucociliary and Cough Clearance by Gamma Scintigraphy Core (W. Bennett)...
- IRON ACQUISITION IN BORDETELLA PERTUSSISSANDRA KAY ARMSTRONG; Fiscal Year: 2010..B. pertussis is the agent that colonizes the human respiratory epithelium to cause whooping cough, or pertussis, and B. bronchiseptica infects a wide range of nonhuman mammals. For iron retrieval, B...
- Neurotrophin Regulation of the Airway Parasympathetic Nervous SystemAllen Myers; Fiscal Year: 2009..such as NGF, are increased in the inflamed or infected airways and many symptoms of these diseases (hyperactivity, cough, mucous production) may be related to altered or aberrant functions of the airway nervous system as seen in asthma,..
- Transmission and the respiratory tract in cryptosporidiosisJeffrey Griffiths; Fiscal Year: 2007..oocysts from induced sputum of children with acute or persistent diarrhea concurrently experiencing cough, with or without fast breathing...
- CT Diagnosis of Tracheomalacia in Patients with COPDPhillip Boiselle; Fiscal Year: 2009..Chronic cough is the fifth most common symptom for which patients seek medical care in the United States, accounting for more ..
- Bordetella pathogenesis: an undergraduate research toolLouise Temple; Fiscal Year: 2007..avium, causes a highly contagious respiratory disease in its avian hosts that has striking similarity to whooping cough in children, caused by B. pertussis. We have the advantage of observing B...
- Effect of Pertussis Toxin on Cough in Guinea PigNICHOLAS CARBONETTI; Fiscal Year: 2005Bordetella pertussis is a gram-negative bacterial pathogen that causes the disease known as pertussis or whooping cough. After respiratory tract infection by the bacteria, the disease is characterized by a severe and prolonged cough, ..
- Neurotrophin Regulation of the Airway Parasympathetic Nervous SystemAllen C Myers; Fiscal Year: 2010..such as NGF, are increased in the inflamed or infected airways and many symptoms of these diseases (hyperactivity, cough, mucous production) may be related to altered or aberrant functions of the airway nervous system as seen in asthma,..
- ASTHMA SEVERITY IN CHILDREN AND ENVIRONMENTAL AGENTSBrian Leaderer; Fiscal Year: 2003..or chronic upper and lower respiratory symptoms in infants age 3-15 months (a sensitive population), including cough, phlegm, wheeze, runny/stuffy nose, etc...
- Neurotrophin Regulation of the Airway Parasympathetic Nervous SystemAllen Myers; Fiscal Year: 2009..such as NGF, are increased in the inflamed or infected airways and many symptoms of these diseases (hyperactivity, cough, mucous production) may be related to altered or aberrant functions of the airway nervous system as seen in asthma,..
- Host-Pathogen Interactions in the Mammalian AirwayGill Diamond; Fiscal Year: 2006..pertussis, the causative agent of whooping cough in humans...
- Photodynamic Therapy for the Treatment of Obstructive E*Todd Demmy; Fiscal Year: 2007..Tumor response and symptom relief (cough, dyspnea, hemoptysis) will be determined at Day 5, one month and three months...
- Reflux Disease in Patients with Throat Signs/SymptomsMichael Vaezi; Fiscal Year: 2005..Laryngoscopic examination of patients with symptoms of hoarseness, sore throat, throat clearing and chronic cough commonly shows laryngeal abnormalities including laryngitis and vocal cord lesions including polyps, granuloma and ..
