cough

Summary

Summary: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.

Top Publications

  1. ncbi The diagnosis and management of chronic cough
    A H Morice
    Division of Academic Medicine, University of Hull, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire HU16 5JQ, UK
    Eur Respir J 24:481-92. 2004
  2. pmc Antibiotic prescribing for acute cough: the effect of perceived patient demand
    Samuel Coenen
    Fund for Scientific Research, Flanders, Belgium
    Br J Gen Pract 56:183-90. 2006
  3. pmc Cough aerosols of Mycobacterium tuberculosis predict new infection: a household contact study
    Edward C Jones-Lopez
    Section of Infectious Diseases, Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, MA 02118, USA
    Am J Respir Crit Care Med 187:1007-15. 2013
  4. pmc Variation in antibiotic prescribing and its impact on recovery in patients with acute cough in primary care: prospective study in 13 countries
    C C Butler
    Department of Primary Care and Public Health, School of Medicine, Cardiff University, Cardiff CF14 4XN, Wales
    BMJ 338:b2242. 2009
  5. ncbi Cough and sputum production as risk factors for poor outcomes in patients with COPD
    Marc Miravitlles
    CIBER de Enfermedades Respiratorias, Hospital Clinic, Barcelona, Spain
    Respir Med 105:1118-28. 2011
  6. pmc Measurements of airborne influenza virus in aerosol particles from human coughs
    William G Lindsley
    Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States of America
    PLoS ONE 5:e15100. 2010
  7. ncbi The duration of acute cough in pre-school children presenting to primary care: a prospective cohort study
    Alastair D Hay
    Division of Primary Health Care, University of Bristol, Cotham House, Cotham Hill, Bristol BS6 6JL, UK
    Fam Pract 20:696-705. 2003
  8. pmc Reduction in the incidence of influenza A but not influenza B associated with use of hand sanitizer and cough hygiene in schools: a randomized controlled trial
    Samuel Stebbins
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Pediatr Infect Dis J 30:921-6. 2011
  9. pmc Diagnosis and management of cough executive summary: ACCP evidence-based clinical practice guidelines
    Richard S Irwin
    University of Massachusetts Medical School, Room S6 842, 55 Lake Ave North, Worcester, MA 01655, USA
    Chest 129:1S-23S. 2006
  10. pmc Predicting aspiration in patients with ischemic stroke: comparison of clinical signs and aerodynamic measures of voluntary cough
    Carol A Smith Hammond
    Durham Veterans Affairs Medical Center, 508 Fulton Street, Durham, NC 27705, USA
    Chest 135:769-77. 2009

Detail Information

Publications361 found, 100 shown here

  1. ncbi The diagnosis and management of chronic cough
    A H Morice
    Division of Academic Medicine, University of Hull, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire HU16 5JQ, UK
    Eur Respir J 24:481-92. 2004
  2. pmc Antibiotic prescribing for acute cough: the effect of perceived patient demand
    Samuel Coenen
    Fund for Scientific Research, Flanders, Belgium
    Br J Gen Pract 56:183-90. 2006
    GPs decide whether or not to prescribe antibiotics for acute cough. Apart from clinical signs and symptoms, non-medical reasons influence this decision as well.
  3. pmc Cough aerosols of Mycobacterium tuberculosis predict new infection: a household contact study
    Edward C Jones-Lopez
    Section of Infectious Diseases, Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, MA 02118, USA
    Am J Respir Crit Care Med 187:1007-15. 2013
    ..Airborne transmission of Mycobacterium tuberculosis results from incompletely characterized host, bacterial, and environmental factors. Sputum smear microscopy is associated with considerable variability in transmission...
  4. pmc Variation in antibiotic prescribing and its impact on recovery in patients with acute cough in primary care: prospective study in 13 countries
    C C Butler
    Department of Primary Care and Public Health, School of Medicine, Cardiff University, Cardiff CF14 4XN, Wales
    BMJ 338:b2242. 2009
    To describe variation in antibiotic prescribing for acute cough in contrasting European settings and the impact on recovery.
  5. ncbi Cough and sputum production as risk factors for poor outcomes in patients with COPD
    Marc Miravitlles
    CIBER de Enfermedades Respiratorias, Hospital Clinic, Barcelona, Spain
    Respir Med 105:1118-28. 2011
    ..Exacerbations are characterised by periods of increasing acute symptoms, particularly cough, dyspnoea and production of sputum, which worsen airflow obstruction, further impair quality of life and generally ..
  6. pmc Measurements of airborne influenza virus in aerosol particles from human coughs
    William G Lindsley
    Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States of America
    PLoS ONE 5:e15100. 2010
    ..Nasopharyngeal swabs were collected from the volunteers and they were asked to cough three times into a spirometer...
  7. ncbi The duration of acute cough in pre-school children presenting to primary care: a prospective cohort study
    Alastair D Hay
    Division of Primary Health Care, University of Bristol, Cotham House, Cotham Hill, Bristol BS6 6JL, UK
    Fam Pract 20:696-705. 2003
    Professional and parental uncertainty about the natural history of cough in pre-school children may in part be responsible for the high consultation and reconsultation rates and widespread antibiotic use in primary care...
  8. pmc Reduction in the incidence of influenza A but not influenza B associated with use of hand sanitizer and cough hygiene in schools: a randomized controlled trial
    Samuel Stebbins
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Pediatr Infect Dis J 30:921-6. 2011
    ..Laboratory-based evidence is lacking regarding the efficacy of nonpharmaceutical interventions (NPIs) such as alcohol-based hand sanitizer and respiratory hygiene to reduce the spread of influenza...
  9. pmc Diagnosis and management of cough executive summary: ACCP evidence-based clinical practice guidelines
    Richard S Irwin
    University of Massachusetts Medical School, Room S6 842, 55 Lake Ave North, Worcester, MA 01655, USA
    Chest 129:1S-23S. 2006
  10. pmc Predicting aspiration in patients with ischemic stroke: comparison of clinical signs and aerodynamic measures of voluntary cough
    Carol A Smith Hammond
    Durham Veterans Affairs Medical Center, 508 Fulton Street, Durham, NC 27705, USA
    Chest 135:769-77. 2009
    ..We hypothesized that objective measure of voluntary cough would improve the accuracy of the clinical evaluation of swallow to predict those patients who are at risk.
  11. ncbi Detection of infectious influenza virus in cough aerosols generated in a simulated patient examination room
    John D Noti
    Health Effects Laboratory Division HELD, National Institute for Occupational Safety and Health NIOSH, Centers for Disease Control and Prevention CDC, Morgantown, WV, USA
    Clin Infect Dis 54:1569-77. 2012
    ....
  12. pmc Barriers to accessing TB diagnosis for rural-to-urban migrants with chronic cough in Chongqing, China: a mixed methods study
    Qian Long
    School of Public Health, Chongqing Medical University, No 1 Yixueyuan Road, Chongqing, PR China
    BMC Health Serv Res 8:202. 2008
    ..seeking behaviour of and health systems responses to migrants and permanent urban residents suffering from chronic cough, in order to identify the factors influencing delays for both groups in receiving a TB diagnosis in urban China.
  13. ncbi Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough
    David A Groneberg
    Division of Allergy Research, Department of Pediatric Pneumology and Immunology, Charité Faculty of Medicine, Humboldt Universitat zu Berlin, Germany
    Am J Respir Crit Care Med 170:1276-80. 2004
    Transient receptor potential vanniloid-1 (TRPV-1) mediates the cough response induced by the pepper extract capsaicin and is expressed in sensory nerves that innervate the airway wall...
  14. ncbi Cough and sputum production are associated with frequent exacerbations and hospitalizations in COPD subjects
    Pierre Regis Burgel
    Service de Pneumologie, Hopital Cochin, Assistance Publique Hopitaux de Paris, 27 rue du Faubourg St Jacques, Paris Cedex 14, France
    Chest 135:975-82. 2009
    Epidemiologic studies indicate that chronic cough and sputum production are associated with increased mortality and disease progression in COPD subjects...
  15. ncbi Prevalence of chronic obstructive pulmonary disease in China: a large, population-based survey
    Nanshan Zhong
    Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical College, 151 Yanjiang Road, Guangzhou, Guangdong 510120, China
    Am J Respir Crit Care Med 176:753-60. 2007
    ..The prevalence of chronic obstructive pulmonary disease (COPD) in China is largely unknown...
  16. ncbi ERS guidelines on the assessment of cough
    A H Morice
    Cardiovascular and Respiratory Studies, Respiratory Medicine, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire, and Imperial College London, UK
    Eur Respir J 29:1256-76. 2007
  17. ncbi Pathophysiology of headache associated with cough in patients with Chiari I malformation
    Charles A Sansur
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 98:453-8. 2003
    The aim of this study was to evaluate the pathophysiology underlying headache associated with cough in patients with Chiari I tonsillar abnormality...
  18. ncbi Thalidomide for the treatment of cough in idiopathic pulmonary fibrosis: a randomized trial
    Maureen R Horton
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Intern Med 157:398-406. 2012
    Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disorder of unknown cause with no effective treatment. Cough affects up to 80% of patients with IPF, is frequently disabling, and lacks effective therapy.
  19. pmc Transient receptor potential channels mediate the tussive response to prostaglandin E2 and bradykinin
    Megan Grace
    Respiratory Pharmacology Group, Pharmacology and Toxicology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Thorax 67:891-900. 2012
    b>Cough is the most frequent reason for consultation with a family doctor, or with a general or respiratory physician...
  20. ncbi Toward understanding the risk of secondary airborne infection: emission of respirable pathogens
    Mark Nicas
    School of Public Health, University of California, Berkeley, Berkeley, California 94720, USA
    J Occup Environ Hyg 2:143-54. 2005
    ..emitted particles quickly decrease in diameter due to water loss to one-half the initial values, and that in one cough the volume in particles with initial diameters less than 20 microm is 60 x 10(-8) mL...
  21. ncbi Voluntary and reflex cough and the expiration reflex; implications for aspiration after stroke
    J G Widdicombe
    Univ London, 116 Pepys Road, London SW208NY, UK
    Pulm Pharmacol Ther 24:312-7. 2011
    Aspiration is a common result of stroke, and may lead to lung infections and pneumonia. Cough may prevent this aspiration and thus prevent the pneumonia...
  22. pmc RSD931, a novel anti-tussive agent acting on airway sensory nerves
    J J Adcock
    Pneumolabs UK Ltd, NPIMR, Y Block, Watford Road, Harrow, Middlesex HA1 3UJ, UK
    Br J Pharmacol 138:407-16. 2003
    ..05), 40.4% (P>0.05) and 97.6% (P<0.01) for RSD931, respectively and increased the latency to onset of cough at 10.0 mg ml(-1) only...
  23. pmc General practitioners' views on the acceptability and applicability of a web-based intervention to reduce antibiotic prescribing for acute cough in multiple European countries: a qualitative study prior to a randomised trial
    Sibyl Anthierens
    Centre for General Practice, Vaccine and Infectious Disease Institute VAXINFECTIO, Laboratory of Microbiology, University of Antwerp, Antwerp, Belgium
    BMC Fam Pract 13:101. 2012
    ..needed to deliver training to GPs in the use of C-Reactive Protein (CRP) near patient tests to help diagnose acute cough and in communication skills to help explain prescribing decisions to patients...
  24. pmc Detection of pulmonary tuberculosis among patients with cough attending outpatient departments in Dar Es Salaam, Tanzania: does duration of cough matter?
    Esther S Ngadaya
    Centre for International Health, University of Bergen, Bergen, Norway
    BMC Health Serv Res 9:112. 2009
    ..Currently, one of the defining criteria for suspecting tuberculosis is cough for two weeks or more...
  25. pmc Inhibitory activity of the novel CB2 receptor agonist, GW833972A, on guinea-pig and human sensory nerve function in the airways
    M G Belvisi
    Respiratory Pharmacology Group, Airway Disease Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK
    Br J Pharmacol 155:547-57. 2008
    Sensory nerves regulate central and local reflexes such as airway plasma protein leakage, bronchoconstriction and cough. Sensory nerve activity may be enhanced during inflammation such that these protective effects become exacerbated and ..
  26. ncbi Chronic wet cough: Protracted bronchitis, chronic suppurative lung disease and bronchiectasis
    A B Chang
    Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Pediatr Pulmonol 43:519-31. 2008
    ..airways (endobronchial infection) in the causation of chronic respiratory symptoms, particularly chronic wet cough, has received very little attention over recent decades other than in the context of cystic fibrosis (CF)...
  27. pmc The validity and precision of the Leicester Cough Questionnaire in COPD patients with chronic cough
    Farida F Berkhof
    Isala Klinieken, Department of Pulmonary Diseases, Zwolle, The Netherlands
    Health Qual Life Outcomes 10:4. 2012
    A validated instrument to assess the effects of chronic cough on health status in patients with chronic obstructive pulmonary disease (COPD) is currently not available...
  28. pmc Neurogenesis of cough, other airway defensive behaviors and breathing: A holarchical system?
    Donald C Bolser
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA
    Respir Physiol Neurobiol 152:255-65. 2006
    b>Cough and breathing are generated by a common muscular system. However, these two behaviors differ significantly in their mechanical features and regulation...
  29. ncbi The breathlessness, cough, and sputum scale: the development of empirically based guidelines for interpretation
    Nancy Kline Leidy
    Center for Health Outcomes Research, MEDTAP International Inc, 7101 Wisconsin Avenue, Suite 600, Bethesda, MD 20814, USA
    Chest 124:2182-91. 2003
    ..A patient report of respiratory symptoms in COPD is essential to successfully monitoring disease, adjusting treatment, and evaluating outcomes...
  30. ncbi Production of reflex cough by brainstem respiratory networks
    R Shannon
    Department of Physiology and Biophysics, MDC Box 8, University of South Florida Health Sciences Center, 12901 Bruce B Downs Blvd Tampa, FL 33612 4799, USA
    Pulm Pharmacol Ther 17:369-76. 2004
    Delineation of neural mechanisms involved in reflex cough is essential for understanding its many physiological and clinical complexities, and the development of more desirable antitussive agents...
  31. ncbi Acoustic cough-reflux associations in chronic cough: potential triggers and mechanisms
    Jaclyn A Smith
    Respiratory Research Group, The University of Manchester, Manchester, UK
    Gastroenterology 139:754-62. 2010
    Central sensitization is thought to play a role in chronic cough and might explain the temporal association between cough and gastroesophageal reflux (GOR) in patients in whom non-GOR causes have been excluded...
  32. ncbi Acidification of the oesophagus acutely increases the cough sensitivity in patients with gastro-oesophageal reflux and chronic cough
    N Javorkova
    Department of Pathophysiology, Jessenius Faculty of Medicine, Martin, Slovakia
    Neurogastroenterol Motil 20:119-24. 2008
    Gastro-oesophageal reflux disease (GORD) is one of the most common causes of chronic cough; however, the mechanisms by which GOR initiates coughing are incompletely understood...
  33. pmc Encoding of the cough reflex in anesthetized guinea pigs
    Brendan J Canning
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Physiol Regul Integr Comp Physiol 300:R369-77. 2011
    We have previously described the physiological and morphological properties of the cough receptors and their sites of termination in the airways and centrally in the nucleus tractus solitarius (nTS)...
  34. pmc Development of a symptom specific health status measure for patients with chronic cough: Leicester Cough Questionnaire (LCQ)
    S S Birring
    Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK
    Thorax 58:339-43. 2003
    Chronic cough is a common condition which has a significant impact on quality of life. Assessment and management are hampered by the absence of well validated outcome measures...
  35. ncbi How far droplets can move in indoor environments--revisiting the Wells evaporation-falling curve
    X Xie
    Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, China
    Indoor Air 17:211-25. 2007
    ..There is a need to examine the air distribution systems in hospital wards for controlling both airborne and droplet-borne transmitted diseases...
  36. ncbi Cough-generated aerosols of Mycobacterium tuberculosis: a new method to study infectiousness
    Kevin P Fennelly
    Department of Medicine, Center for the Study of Emerging and Re Emerging Pathogens, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Am J Respir Crit Care Med 169:604-9. 2004
    ..We aimed to assess the feasibility of a method that we developed to collect and quantify culturable cough-generated aerosols of Mycobacterium tuberculosis...
  37. ncbi Cough hypersensitivity syndrome: a distinct clinical entity
    A H Morice
    Cardiovascular and Respiratory Studies, Castle Hill Hospital, Hull York Medical School, University of Hull, Castle Road, Cottingham, East Yorkshire HU16 5JQ, UK
    Lung 189:73-9. 2011
    We postulate that most patients with chronic cough have a single discrete clinical entity: cough hypersensitivity syndrome. We constructed a questionnaire that elicits the major components of the syndrome...
  38. ncbi Chronic 'cough hypersensitivity syndrome': a more precise label for chronic cough
    K F Chung
    National Heart and Lung Institute, Imperial College, Dovehouse St, London SW3 6LY, UK
    Pulm Pharmacol Ther 24:267-71. 2011
    Chronic cough remains a challenge to many clinicians because there is often no diagnostic link to causation, and because indirect antitussives are largely ineffective...
  39. pmc Prostaglandin E2 mediates cough via the EP3 receptor: implications for future disease therapy
    Sarah A Maher
    Respiratory Pharmacology, Airways Diseases, Imperial College London, Faculty of Medicine, National Heart and Lung Institute, Sir Alexander Fleming Building, London, SW7 2AZ, UK
    Am J Respir Crit Care Med 180:923-8. 2009
    ..Inhaled prostaglandin E(2) (PGE(2)) is antiinflammatory and a bronchodilator in patients with asthma, but it also causes cough.
  40. ncbi Exhalation of respiratory viruses by breathing, coughing, and talking
    Sacha Stelzer-Braid
    Faculty of Science, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, NSW, Australia
    J Med Virol 81:1674-9. 2009
    ..In the subset of exhaled samples from 10 subjects examined by culture, infective rhinovirus was detected in 2. These data provide further evidence that breathing may be a source of respirable particles carrying infectious virus...
  41. pmc Increased tachykinin levels in induced sputum from asthmatic and cough patients with acid reflux
    Robert N Patterson
    Department of Medicine, Queen s University Belfast, and Regional Respiratory Centre, Belfast City Hospital, Grosvenor Road, Belfast BT12 6BJ, UK
    Thorax 62:491-5. 2007
    Acid reflux may aggravate airway disease including asthma and chronic cough. One postulated mechanism concerns a vagally-mediated oesophageal-tracheobronchial reflex with airway sensory nerve activation and tachykinin release.
  42. ncbi Chronic idiopathic cough: a discrete clinical entity?
    Rubaiyat A Haque
    Airways Disease Section, National Heart and Lung Institute, Imperial College, Dovehouse St, London, SW3 6LY, UK
    Chest 127:1710-3. 2005
    Despite the success of specialist cough clinics, there is increasing recognition of a subgroup of chronic coughers in whom a diagnosis cannot be made even after thorough, systematic investigation...
  43. ncbi Flow dynamics and characterization of a cough
    J K Gupta
    National Air Transportation Center of Excellence for Research in the Intermodal Transport Environment RITE, School of Mechanical Engineering, Purdue University, West Lafayette, IN 47906 2088, USA
    Indoor Air 19:517-25. 2009
    Airborne disease transmission has always been a topic of wide interests in various fields for decades. Cough is found to be one of the prime sources of airborne diseases as it has high velocity and large quantity of droplets...
  44. pmc Weakly acidic reflux in patients with chronic unexplained cough during 24 hour pressure, pH, and impedance monitoring
    D Sifrim
    Faculty of Medicine, KU Leuven, Lab G I Physiopathology, O and N Gasthuisberg, 7th Floor, Herestraat 49, 3000, Leuven, Belgium
    Gut 54:449-54. 2005
    Acid gastro-oesophageal reflux is one of the most important causes of chronic cough. The response to acid suppression in these patients is not as good as in patients with heartburn but improvement with antireflux surgery has been ..
  45. ncbi An algorithm for tuberculosis screening and diagnosis in people with HIV
    Kevin P Cain
    U S Centers for Disease Control and Prevention, Division of Tuberculosis Elimination, Atlanta, GA 30333, USA
    N Engl J Med 362:707-16. 2010
    ..No internationally accepted, evidence-based guideline addresses the optimal means of conducting such screening, although screening for chronic cough is common.
  46. ncbi The size and concentration of droplets generated by coughing in human subjects
    Shinhao Yang
    Department of Environmental and Occupational Health, Toko University, Taiwan, Republic of China
    J Aerosol Med 20:484-94. 2007
    ..Comparison of the droplet concentrations for subjects in different age groups demonstrated that subjects in the 30-50-year age group have the largest droplet concentrations...
  47. ncbi Neural correlates coding stimulus level and perception of capsaicin-evoked urge-to-cough in humans
    Michael J Farrell
    Florey Neurosciences Institutes, University of Melbourne, VIC 3010, Australia
    Neuroimage 61:1324-35. 2012
    ..Subjective ratings of the urge-to-cough were also made during capsaicin challenges...
  48. doi Internal jugular vein valve insufficiency in cough syncope
    Grzegorz Styczynski
    Department of Internal Medicine, Hypertension and Angiology, Medical University of Warsaw, Banacha 1a, 02 097 Warsaw, Poland
    Neurology 70:812-3. 2008
  49. pmc Synergistic interactions between airway afferent nerve subtypes regulating the cough reflex in guinea-pigs
    Stuart B Mazzone
    The Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Physiol 569:559-73. 2005
    b>Cough initiated from the trachea and larynx in anaesthetized guinea-pigs is mediated by capsaicin-insensitive, mechanically sensitive vagal afferent neurones...
  50. pmc Cough aerosol in healthy participants: fundamental knowledge to optimize droplet-spread infectious respiratory disease management
    Gustavo Zayas
    Mucophysiology Laboratory, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada
    BMC Pulm Med 12:11. 2012
    ..The objective of the current study was to characterize the human cough aerosol pattern with the aim of developing a standard human cough bioaerosol model for Influenza Pandemic control.
  51. pmc Airflow dynamics of coughing in healthy human volunteers by shadowgraph imaging: an aid to aerosol infection control
    Julian W Tang
    Department of Laboratory Medicine, National University Hospital, Queenstown, Singapore
    PLoS ONE 7:e34818. 2012
    b>Cough airflow dynamics have been previously studied using a variety of experimental methods...
  52. ncbi Chronic cough and esomeprazole: a double-blind placebo-controlled parallel study
    Shoaib Faruqi
    Division of Cardiovascular and Respiratory Studies, Hull York Medical School, University of Hull, Castle Hill Hospital, Cottingham, UK
    Respirology 16:1150-6. 2011
    Gastro-oesophageal reflux has been implicated in the pathogenesis of chronic cough. Guidelines on management suggest a therapeutic trial of anti-reflux medication...
  53. ncbi Incidence of chronic obstructive pulmonary disease in a cohort of young adults according to the presence of chronic cough and phlegm
    Roberto de Marco
    Sezione di Epidemiologia and Statistica Medica, Dipartimento di Medicina e Sanita Pubblica, Universita degli Studi di Verona, c o Istituti Biologici II, Strada Le Grazie 8 37134, Verona, Italy
    Am J Respir Crit Care Med 175:32-9. 2007
    The few prospective studies aimed at assessing the incidence of chronic obstructive pulmonary disease (COPD) in relation to the presence of chronic cough/phlegm have produced contrasting results.
  54. ncbi Transport of expiratory droplets in an aircraft cabin
    Jitendra K Gupta
    National Air Transportation Center of Excellence for Research in the Intermodal Transport Environment, School of Mechanical Engineering, Purdue University, West Lafayette, IN, USA
    Indoor Air 21:3-11. 2011
    ..The droplets exhaled were from a single cough, a single breath, and a 15-s talk of the index patient...
  55. pmc Jugular venous reflux and plasma endothelin-1 are associated with cough syncope: a case control pilot study
    Chih Ping Chung
    Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan
    BMC Neurol 13:9. 2013
    Jugular venous reflux (JVR) has been reported to cause cough syncope via retrograde-transmitted venous hypertension and consequently decreased cerebral blood flow (CBF)...
  56. ncbi Determinants of cough in young adults participating in the European Community Respiratory Health Survey
    C Janson
    Dept of Medical Sciences, Respiratory Medicine and Allergology, Uppsala University, Sweden
    Eur Respir J 18:647-54. 2001
    b>Cough is a common symptom that affects a large proportion of the general population...
  57. ncbi Distal esophagitis in patients with mustard-gas induced chronic cough
    M Ghanei
    Research Center for Chemical Injuries, Baqiyatallah University of Medical Sciences, Tehran, Iran
    Dis Esophagus 19:285-8. 2006
    ..In addition, they were suffering from asthma, chronic bronchitis and bronchiectasis. Bronchiolitis obliterans, along with other lung disorders, can be considered as contributors in the pathogenesis of esophagitis in MG exposed patients...
  58. ncbi Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough
    Antonio Grilo
    Unidad de Hipertension, Servicio de Medicina Interna, Hospital Universitario de Valme, Carretera de Cádiz S N bNeocodex, Avda, Charles Darwin, Acc A Seville, Spain
    Pharmacogenet Genomics 21:10-7. 2011
    ..Persistent cough is a common adverse reaction associated with ACEi, which can bind to the treatment cessation, but its etiology ..
  59. pmc Blood pressure changes alter tracheobronchial cough: computational model of the respiratory-cough network and in vivo experiments in anesthetized cats
    Ivan Poliacek
    Dept of Physiological Sciences, College of Veterinary Medicine, Univ of Florida, Gainesville, FL 32610, USA
    J Appl Physiol (1985) 111:861-73. 2011
    We tested the hypothesis, motivated in part by a coordinated computational cough network model, that alterations of mean systemic arterial blood pressure (BP) influence the excitability and motor pattern of cough...
  60. ncbi Cough hypersensitivity syndrome is an important clinical concept: a pro/con debate
    Alyn H Morice
    Cardiovascular and Respiratory Studies, University of Hull, Hull York Medical School, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire HU16 5JQ, UK
    Lung 190:3-9. 2012
    The major etiologies of chronic cough are generally accepted to consist of upper airway cough syndrome (formerly postnasal drip syndrome), eosinophilic airway inflammation (asthma, nonasthmatic eosinophilic bronchitis), and ..
  61. ncbi Gabapentin in the treatment of intractable idiopathic chronic cough: case reports
    Sheldon Mintz
    Am J Med 119:e13-5. 2006
  62. ncbi On the psychology of cough
    Omer Van den Bergh
    Health Psychology, University of Leuven, Tiensestraat 102, B 3000 Leuven, Belgium
    Lung 190:55-61. 2012
    Neurobiological research is increasingly documenting the role of higher brain areas in cough, but little systematic behavioral research on the role of psychological factors exists...
  63. ncbi Controversies in the evaluation and management of chronic cough
    Surinder S Birring
    King s College London, Division of Asthma, Allergy and Lung Biology, Denmark Hill, London SE5 9RS, UK
    Am J Respir Crit Care Med 183:708-15. 2011
    Chronic cough that cannot be explained after basic evaluation is a common reason for patients to be referred to respiratory outpatient clinics...
  64. ncbi Clinical, physiological and anti-inflammatory effect of montelukast in patients with cough variant asthma
    Masaya Takemura
    Departments of Respiratory Medicine, Kyoto University, Kyoto, Japan
    Respiration 83:308-15. 2012
    b>Cough variant asthma (CVA) is a phenotype of asthma presenting solely with coughing, characterized by airway hyperresponsiveness, eosinophilic inflammation and a cough response to bronchodilators...
  65. pmc Volitional control of reflex cough
    Karen W Hegland
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA
    J Appl Physiol (1985) 113:39-46. 2012
    Multiple studies suggest a role for the cerebral cortex in the generation of reflex cough in awake humans...
  66. ncbi Chronic refractory cough as a sensory neuropathy: evidence from a reinterpretation of cough triggers
    Anne E Vertigan
    Department of Speech Pathology, John Hunter Hospital, Newcastle, Australia
    J Voice 25:596-601. 2011
    The aims of this study were to examine cough triggers in individuals with chronic cough (CC), identify sensory symptoms consistent with central reflex sensitization (paresthesia and allotussia), and interpret this information in relation ..
  67. pmc How respiratory muscle strength correlates with cough capacity in patients with respiratory muscle weakness
    Jung Hyun Park
    Department of Rehabilitation Medicine, Eulji University Hospital, Daejeon, Korea
    Yonsei Med J 51:392-7. 2010
    The purpose of this study is to investigate how respiratory muscle strength correlates to cough capacity in patients with respiratory muscle weakness.
  68. pmc Cough: an unmet clinical need
    Peter V Dicpinigaitis
    Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10461, USA
    Br J Pharmacol 163:116-24. 2011
    b>Cough is among the most common complaints for which patients worldwide seek medical attention. Thus, the evaluation and treatment of cough result in tremendous financial expenditure and consumption of health care resources...
  69. ncbi Functional implications of the multiple afferent pathways regulating cough
    Brendan J Canning
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Pulm Pharmacol Ther 24:295-9. 2011
    ..of capsaicin-sensitive C-fibers innervating these airways will also produce coughing, but C-fiber dependent cough is prevented entirely by anesthesia...
  70. ncbi Pepsin and bile acids in induced sputum of chronic cough patients
    Marcin Grabowski
    Department of Internal Medicine, Geriatrics and Allergology, Wroclaw Medical University, Wroclaw, Poland
    Respir Med 105:1257-61. 2011
    One of the theories which explain, why gastroesophageal reflux disease (GORD) may provoke cough, is the occurrence of aspiration of gastric content into the airways...
  71. ncbi Nonacid reflux episodes reaching the pharynx are important factors associated with cough
    Neil Patterson
    Department of Medicine, Royal Hospitals, Grosvenor Road, Belfast, UK
    J Clin Gastroenterol 43:414-9. 2009
    Gastroesophageal reflux is implicated in the pathogenesis of asthma and chronic cough. To date most studies have focused on acid reflux measured by pH below the upper esophageal sphincter (UES)...
  72. ncbi Validation of the Leicester Cough Questionnaire in non-cystic fibrosis bronchiectasis
    M P Murray
    Royal Infirmary of Edinburgh, Department of Respiratory Medicine, 51 Little France Crescent, Old Dalkeith Road, Edinburgh, EH16 4SA, UK
    Eur Respir J 34:125-31. 2009
    ..The Leicester Cough Questionnaire (LCQ) is a symptom specific questionnaire designed to assess the impact of cough severity, a major ..
  73. ncbi Prevalence, pathogenesis, and causes of chronic cough
    Kian Fan Chung
    Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, UK
    Lancet 371:1364-74. 2008
    b>Cough is a reflex action of the respiratory tract that is used to clear the upper airways. Chronic cough lasting for more than 8 weeks is common in the community...
  74. ncbi Afferent neural pathways in cough and reflex bronchoconstriction
    J A Karlsson
    Pharmacological Laboratory, AB Draco, Lund, Sweden
    J Appl Physiol (1985) 65:1007-23. 1988
    b>Cough and bronchoconstriction are airway reflexes that protect the lung from inspired noxious agents. These two reflexes can be evoked both from the larynx and tracheobronchial tree and also from some extrarespiratory sites...
  75. pmc Delay in diagnosis of pulmonary tuberculosis at a primary health clinic in Vitoria, Brazil
    E L N Maciel
    Nucleo de Doencas Infecciosas, Universidade Federal do Espirito Santo, Vitoria, Espirito Santo, Brazil
    Int J Tuberc Lung Dis 14:1403-10. 2010
    ..Primary health clinics in Vitoria, Espirito Santo, Brazil...
  76. pmc Identification of the tracheal and laryngeal afferent neurones mediating cough in anaesthetized guinea-pigs
    Brendan J Canning
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Physiol 557:543-58. 2004
    We have identified the tracheal and laryngeal afferent nerves regulating cough in anaesthetized guinea-pigs...
  77. ncbi Antibiotic use and health-seeking behaviour in an underprivileged area of Perú
    C Kristiansson
    Department of Public Health Science, Division of International Health IHCAR, Karolinska Institutet, Stockholm, Sweden
    Trop Med Int Health 13:434-41. 2008
    ..To describe the health-seeking behaviour and use of antibiotics in the urban community of Yurimaguas in the Amazonian area of Peru...
  78. ncbi Chronic cough due to gastroesophageal reflux disease: failure to resolve despite total/near-total elimination of esophageal acid
    Richard S Irwin
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Chest 121:1132-40. 2002
    While medical therapy may fail to improve cough due to gastroesophageal reflux disease (GERD), it is not known if inadequate esophageal acid suppression is responsible.
  79. ncbi Vagal afferent nerves regulating the cough reflex
    Brendan J Canning
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Respir Physiol Neurobiol 152:223-42. 2006
    ..All afferent nerve subtypes innervating the airways can modulate the cough reflex...
  80. pmc Abnormal oesophageal motility in patients with chronic cough
    J A Kastelik
    Division of Academic Medicine, Postgraduate Medical Institute, University of Hull, Hull, UK
    Thorax 58:699-702. 2003
    Although gastro-oesophageal reflux is a recognised cause of chronic cough, the role of oesophageal dysmotility is unknown...
  81. pmc TRPA1 agonists evoke coughing in guinea pig and human volunteers
    Mark A Birrell
    Respiratory Pharmacology Group, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Am J Respir Crit Care Med 180:1042-7. 2009
    b>Cough is the most frequent reason for consultation with a family doctor, or with a general or respiratory physician. Treatment options are limited and one meta-analysis concluded that over-the-counter remedies are ineffective...
  82. pmc Detecting patients at a high risk of developing chronic obstructive pulmonary disease in general practice: cross sectional case finding study
    C P van Schayck
    Department of General Practice, Research Institute ExTra, University of Maastricht, Postbox 616, 6200 MD Maastricht, Netherlands
    BMJ 324:1370. 2002
    ..To investigate the effectiveness of case finding of patients at risk of developing chronic obstructive pulmonary disease, whether the method is suitable for use in general practice, how patients should be selected, and the time required...
  83. pmc Comparison of symptoms and treatment outcomes between actively and passively detected tuberculosis cases: the additional value of active case finding
    S den Boon
    Desmond Tutu TB Centre, Stellenbosch University, South Africa
    Epidemiol Infect 136:1342-9. 2008
    ..01, CI 0.33-3.09). Passively detected cases reported the presence of the symptoms cough (OR 3.72, 95% CI 1.47-9.39), haemoptysis (OR 3.20, 95% CI 1.03-9.93), night sweats (OR 3.35, 95% CI 1.40-7...
  84. ncbi Representation of capsaicin-evoked urge-to-cough in the human brain using functional magnetic resonance imaging
    Stuart B Mazzone
    The Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia 3010
    Am J Respir Crit Care Med 176:327-32. 2007
    Coughing in humans is typically preceded by a desire (or urge) to cough. The neural circuitry involved in sensing airway irritation and generating the urge-to-cough in humans is essentially unknown.
  85. ncbi Clinical signs and symptoms predicting influenza infection
    A S Monto
    University of Michigan, 3080 SPH 1, 109 Observatory St, Ann Arbor, MI 48109 2029, USA
    Arch Intern Med 160:3243-7. 2000
    ..In clinical practice, antiviral use has rarely been guided by antecedent laboratory diagnosis. Defined clinical predictors of an influenza infection can help guide timely therapy and avoid unnecessary antibiotic use...
  86. pmc Sensitivity and specificity of fluorescence microscopy for diagnosing pulmonary tuberculosis in a high HIV prevalence setting
    A Cattamanchi
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, California, USA
    Int J Tuberc Lung Dis 13:1130-6. 2009
    ..Mulago Hospital, Kampala, Uganda...
  87. pmc Headaches precipitated by cough, prolonged exercise or sexual activity: a prospective etiological and clinical study
    Julio Pascual
    Service of Neurology, University Hospital of Salamanca, 37007, Salamanca, Spain
    J Headache Pain 9:259-66. 2008
    Headaches provoked by cough, prolonged physical exercise and sexual activity have not been studied prospectively, clinically and neuroradiologically...
  88. ncbi Sex-related differences in cough reflex sensitivity in patients with chronic cough
    Jack A Kastelik
    Academic Department of Medicine, University of Hull, Castle Hill Hospital, Cottingham, United Kingdom
    Am J Respir Crit Care Med 166:961-4. 2002
    Among patients attending specialist cough clinics there is an excess of females, but the reason for this sex difference is unknown...
  89. ncbi Sex differences and predictors of objective cough frequency in chronic cough
    A Kelsall
    Education and Research Centre, Wythenshawe Hospital, Manchester, UK
    Thorax 64:393-8. 2009
    Women are consistently over-represented in specialist cough clinics and known to have a more sensitive cough reflex than men. Whether female sex and other patient characteristics are associated with higher cough rates is not known...
  90. ncbi Chronic cough and phlegm in young adults
    I Cerveri
    Division of Respiratory Diseases, IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy
    Eur Respir J 22:413-7. 2003
    The Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines underline that the presence of chronic cough and sputum production before airflow obstruction offers a unique opportunity to identify subjects at risk of ..
  91. ncbi High infectivity and pathogenicity of influenza A virus via aerosol and droplet transmission
    Peter F M Teunis
    Centre for Infectious Disease Control, Epidemiology and Surveillance Unit, RIVM, Anthonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, Netherlands
    Epidemics 2:215-22. 2010
    ..More studies are needed to clarify the role of different modes of transmission in other settings...
  92. ncbi Dispersion and exposure to a cough-generated aerosol in a simulated medical examination room
    William G Lindsley
    National Institute for Occupational Safety and Health, Health Effects Laboratory Division, 1095 Willowdale Road, Morgantown, WV 26505 2845, USA
    J Occup Environ Hyg 9:681-90. 2012
    ..The system has three main parts: (1) a coughing simulator that expels an aerosol-laden cough through a head form; (2) a breathing simulator with a second head form that can be fitted with respiratory PPE; ..
  93. ncbi Effects of intranasal capsaicin challenge on cough reflex in healthy human volunteers
    J Plevkova
    Department of Pathophysiology, Jessenius School of Medicine, Martin Comenius University, Martin, Slovakia
    J Physiol Pharmacol 55:101-6. 2004
    Rhinosinusitis is the most common cause of chronic cough. There is clinical experience that cough can be elicited from lower airways including the larynx...
  94. pmc Reduced pH and chloride levels in exhaled breath condensate of patients with chronic cough
    A Niimi
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, Dovehouse Street, London SW3 6LY, UK
    Thorax 59:608-12. 2004
    Increased hydrogen and reduced chloride ionic environments of the airways are conducive to the stimulation of cough. However, the constituents of the local milieu of the airways of patients with chronic cough are unknown.
  95. pmc A schlieren optical study of the human cough with and without wearing masks for aerosol infection control
    Julian W Tang
    Department of Laboratory Medicine, National University of Singapore, Singapore
    J R Soc Interface 6:S727-36. 2009
    ..Further, a high-speed schlieren video of a single cough is analysed by a computerized method of tracking individual turbulent eddies, demonstrating the non-intrusive ..
  96. ncbi Involvement of P2X receptor subtypes in ATP-induced enhancement of the cough reflex sensitivity
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Pharmacol 528:158-61. 2005
    ..These results suggest that although ATP, by itself, does not elicit spontaneous coughs, it likely enhances the cough reflex sensitivity...
  97. ncbi New insights in cough
    Ashley Woodcock
    University Hospital of South Manchester, Southmoor Road, Manchester, UK
    Br Med Bull 96:61-73. 2010
    Chronic cough is common, blights patients' lives and is hard to treat. Chronic cough patients demonstrate high objective cough rates and as a group have increased cough reflex sensitivity...
  98. ncbi Vital-sign abnormalities as predictors of pneumonia in adults with acute cough illness
    Brendon R Nolt
    The Center for Health Equity Research and Promotion, VA Medical Center and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Am J Emerg Med 25:631-6. 2007
    This study examines the strength of the association between vital-sign abnormalities, advanced age, and the diagnosis of community-acquired pneumonia (CAP) in the evaluation of adults with acute cough illness.
  99. ncbi Effect of tartaric acid-induced cough on pulmonary function in normal and asthmatic humans
    W Robert Addington
    Brevard Rehabilitation Medicine, Melbourne, Florida, USA
    Am J Phys Med Rehabil 82:374-8. 2003
    The laryngeal cough reflex and the laryngeal cough expiratory reflex are brainstem reflexes that protect the upper airway from significant aspiration...
  100. pmc Randomised clinical trial: high-dose acid suppression for chronic cough - a double-blind, placebo-controlled study
    N J Shaheen
    Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, 27599 7080, USA
    Aliment Pharmacol Ther 33:225-34. 2011
    b>Cough may be a manifestation of gastro-oesophageal reflux disease (GERD). The utility of acid suppression in GERD-related cough is uncertain.
  101. ncbi Chronic cough as a sign of laryngeal sensory neuropathy: diagnosis and treatment
    Bryant Lee
    Department of Otolaryngology Head and Neck Surgery, The Grabscheid Voice Center, Mount Sinai Medical Center, One Gustave L Levy Place, New York, NY 10029, USA
    Ann Otol Rhinol Laryngol 114:253-7. 2005
    Chronic cough is often attributed to reflux, postnasal drip, or asthma. We present 28 patients who had chronic cough or throat-clearing as a manifestation of sensory neuropathy involving the superior or recurrent laryngeal nerve...

Research Grants69

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Dextromethorphan is approved for use as a cough medicine, but it has not been studied to see if it can help in diabetic macular edema...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Dextromethorphan is approved for use as a cough medicine, but it has not been studied to see if it can help in diabetic macular edema...
  3. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas A Platts Mills; Fiscal Year: 2010
    ..Project 4: Mechanisms of pH deviation in asthma and chronic cough: Using new methods of measuring exhaled breath pH, the studies will focus on distinguishing between patients with ..
  4. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
    ..Chronic Obstructive Pulmonary Disease (COPD) is characterized by shortness of breath, cough, and loss of lung tissue (emphysema), which is irreversible and could be progressive...
  5. X-ray Studies of Sugar-Modifying Enzymes
    Hazel Holden; Fiscal Year: 2013
    ..infections and in the A-band trisaccharide of the bacterium Bordetella pertussis, the causative agent of whopping cough. The third sugar, legionaminic acid, was first identified in Legionella pneumophila, the bacterium responsible for ..
  6. Novel immunotherapeutics for the management of otitis media due to H. influenzae
    Steven D Goodman; Fiscal Year: 2013
    ..the sinuses (chronic rhinosinusitis), the tonsils and adenoids (tonsillitis, adenoiditis), the bronchus (chronic cough and bronchitis) and the lung (COPD, early stage CF, community acquired pneumonia)...
  7. Mechanisms of oxidant-induced chronic bronchitis
    ROSANNA C MALBRAN FORTEZA; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE. Chronic bronchitis is an invalidating disease characterized chronic cough and frequent respiratory infections and results in frequent hospitalizations and poor quality of life...
  8. Hospital and Household Studies of Respiratory Cryptosporidiosis and Transmission
    Jeffrey K Griffiths; Fiscal Year: 2013
    ..We recently found that 35% of Ugandan children with Cr. diarrhea and cough were PCR sputum-positive, suggesting that respiratory tract (RT) infection occurs frequently in children with Cr...
  9. Induction of Nerve Growth Factor by Nicotine Leads to Airway Dysfunction
    CHERRY P WONGTRAKOOL; Fiscal Year: 2013
    ..Tobacco smoke is known to trigger asthma symptoms such as wheezing and cough;both are manifestations of airway hyperresponsiveness (AHR)...
  10. Motivational Incentives to Reduce Secondhand Smoke in NICU Infants'Homes
    Angela L Stotts; Fiscal Year: 2013
    ..smoke exposure (SHSe) in children compromises pulmonary function and contributes to respiratory illness, wheeze, cough, asthma, middle ear disease, and sudden infant death syndrome...
  11. Computational and Cell Culture Models for Mucus Clearance
    Richard Superfine; Fiscal Year: 2010
    ..The latter is operative during effective clearance maneuvers such as cough, and it is understood that even in the absence of cilia propulsion, cough can maintain sterile airways...
  12. Preclinical Development of a Novel and Effective Treatment for Cough
    Blake M Paterson; Fiscal Year: 2011
    ..A lack of knowledge regarding the mechanisms of cough has hindered the discovery of new treatments over the past few decades...
  13. Age-associated Toll-like receptor dysfunction in the lungs
    Carlos J Orihuela; Fiscal Year: 2010
    ..in the elderly;2) why 10% of the elderly with pneumonia show no overt clinical signs of infection such as fever, cough, or dyspnea;and 3) why lack of fever is a prognostic indicator of poor clinical outcome...
  14. Developing a Paramyxovirus-based H5N1 Vaccine
    Biao He; Fiscal Year: 2012
    ..Parainfluenza virus 5 (PIV5), a paramyxovirus, causes kennel cough in dogs, but is not known to cause any illness in humans...
  15. TSLP and Childhood Asthma
    Steven F Ziegler; Fiscal Year: 2012
    ..The majority of children infected with RSV experience mild respiratory symptoms with rhinorrhea, cough, and wheezing. However, 1-2% of previously healthy full term infants require hospitalization for RSV bronchiolitis...
  16. A Novel Approach for Mycobacterium Tuberculosis Vaccine Development
    Biao He; Fiscal Year: 2013
    ..Parainfluenza virus 5 (PIV5), a paramyxovirus, is thought to be a contributing factor for causing kennel cough and is not known to cause any illness in humans...
  17. IRON ACQUISITION IN BORDETELLA PERTUSSIS
    SANDRA KAY ARMSTRONG; Fiscal Year: 2013
    ..B. pertussis is the agent that colonizes the human respiratory epithelium to cause whooping cough, or pertussis, and B. bronchiseptica infects a wide range of nonhuman mammals. For iron retrieval, B...
  18. Function and Secretion of Bordetella Filamentous Hemagglutinin
    Peggy A Cotter; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pertussis (also known as whooping cough) continues to be a global health problem with an estimated 45 million cases annually and 300,00 deaths, which occur mostly in children...
  19. Validation of a Genomic Biomarker of Response to Environmental Tobacco Smoke
    AVRUM E SPIRA; Fiscal Year: 2012
    ..adults, and SHS exposure is a substantial source of childhood morbidity;resulting in lower respiratory illnesses;cough, phlegm, wheeze, and breathlessness;middle ear disease;and a lower level of lung function...
  20. Exogenous and Endogenous Biomarkers of CYP2D6 Variability in Pediatrics
    YVONNE SARAH LIN; Fiscal Year: 2013
    ..The activity measurement will utilize the over- the-counter cough suppressant, dextromethorphan or "DM", a standard probe for determining CYP2D6 phenotype...
  21. Translating CBT-Insomnia for Lung Cancer into practice: A RCT
    Grace E Dean; Fiscal Year: 2013
    ..and postoperative radiotherapy can result in impaired pulmonary function resulting in hyperarousal from pain, cough and dyspnea leading to a worsening of insomnia...
  22. 9th International Symposium on Bordetella
    Nicholas H Carbonetti; Fiscal Year: 2010
    ..Bordetella pertussis, the causative agent of the human respiratory disease pertussis (whooping cough) was cultured for the first time in 1906, by Bordet and Gengou, at the Institut Pasteur, and the previous ..
  23. Real-Time Reagent-Free Noninvasive Diagnosis of Tuberculosis
    Payam Nahid; Fiscal Year: 2013
    ..tuberculosis from TB suspects. Patient cough aerosol analysis for M. tuberculosis has the potential to address all these requirements...
  24. Biologic Activities of the pertusis toxin B-pentamer
    ALISON A contact WEISS; Fiscal Year: 2010
    ..Pertussis toxin is the major virulence factor of Bordetella pertussis, the causative agent of human whooping cough or pertussis...
  25. Immunodulation by Bordetella Pertussis of Lymphocytes Trafficking to the Lungs
    Tzvia Abramson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Despite widespread vaccination, whooping cough caused by Bordetella pertussis (Bp) has made a fierce comeback across the world...
  26. TMS in the Management of Postoperative Pain
    Jeffrey J Borckardt; Fiscal Year: 2010
    ..There are many risks associated with opiate use including respiratory depression, nausea and vomiting, cough suppression, mental clouding, sedation and constipation, and many of these side-effects are particularly ..
  27. Exacerbation of pertussis airway inflammation and pathology by pertussis toxin
    Nicholas H Carbonetti; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Pertussis (whooping cough) is a respiratory disease of humans caused by acute infection with the gram-negative bacterial pathogen Bordetella pertussis. In the U.S...
  28. Exacerbation of pertussis airway inflammation and pathology by pertussis toxin
    Nicholas H Carbonetti; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pertussis (whooping cough) is a respiratory disease of humans caused by acute infection with the bacterial pathogen Bordetella pertussis. In the U.S...
  29. Does Intensive Voice Therapy Improve Airway Protection in Parkinsons Disease
    MICHAEL J HAMMER; Fiscal Year: 2012
    ..Disease (PD) is respiratory infection or obstruction resulting from a general failure to effectively cough to protect the airway...
  30. New Intramuscular Electrodes for Respiratory Pacing in SCI
    James S Walter; Fiscal Year: 2012
    ..stimulation and to add abdominal and upper thorax intercostal muscle stimulation for improved respiration and cough. We will test a new electrode for these applications: the PermalocTM bipolar multi-contact (P-BMC) electrode (..
  31. Inhaled aerosols for prevention and treatment of respiratory infections
    Robert W Clarke; Fiscal Year: 2013
    ..of salt aerosols on rheology and the formation of bioaerosols from airway lining fluid using an in vitro simulated cough system and interfacial stress rheometry;2...
  32. Depression and functional outcomes in COPD: Impact of genetics and inflammation
    Huong Q Nguyen; Fiscal Year: 2013
    ..cause of death in the United States, is characterized by chronic, progressive worsening shortness-of-breath, cough and sputum production, and 25- 50% of patients will develop depressive symptoms...
  33. Microfluidic Tissue Engineering of Small Airway Injuries
    Shuichi Takayama; Fiscal Year: 2010
    ..In response to cough, these bridges move and the airway is reopened, with the transmission of mechanical forces to airway epithelial ..
  34. Evaluation of Wire Electrodes to Activate the Expiratory Muscles to Restore Cough
    Anthony F DiMarco; Fiscal Year: 2010
    ..account for significant morbidity and mortality in patients with spinal cord injury due to their inability to cough and clear secretions...
  35. Respiratory Virus Induced Sensory Neuroplasticity
    Bradley J Undem; Fiscal Year: 2013
    ..Viral infections are also thought to be a leading cause of chronic unproductive cough that is said to affect as many as 10% of the population...
  36. Resolution of ozone induced lung injury requires gamma/delta T cells
    Joel A Mathews; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Exposure to ozone (O3), a common air pollutant, causes cough, dyspnea, reductions in lung function, increased susceptibility to lung infections, hospitalizations, increased asthma attacks, and even ..
  37. Airway Sensory Neuroexcitability
    Bradley J Undem; Fiscal Year: 2013
    ..9). In our last aim we address the hypothesis that activation of neural crest C-fiber phenotype enhances the cough reflex, whereas activation of placodal C-fibers actually inhibit the cough reflex...
  38. CT Diagnosis of Tracheomalacia in Patients with COPD
    Phillip M Boiselle; Fiscal Year: 2012
    ..Chronic cough is the fifth most common symptom for which patients seek medical care in the United States, accounting for more ..
  39. Bordetella pathogenesis: an undergraduate research tool
    Louise M Temple; Fiscal Year: 2010
    ..avium, causes a highly contagious respiratory disease in its avian hosts that has striking similarity to whooping cough in children, caused by B. pertussis. We have the advantage of observing B...
  40. Core_plus Option_B_C_Influenza Vaccine Effectiveness in a Wisconsin Population
    Edward Belongia; Fiscal Year: 2013
    ..To estimate vaccine effectiveness, patients with acute respiratory illness (fever, feverishness or cough) will be enrolled from a predefined population cohort during the influenza season...
  41. Arsenic and child respiratory health in Bangladesh
    Allan H Smith; Fiscal Year: 2010
    ..Lung function and respiratory symptoms, including chronic cough and shortness of breath, will be assessed in relation to current and past arsenic concentrations in all sources of ..
  42. Accuracy of Examining Cough Function and its Relationship to Airway Protection
    Christine M Sapienza; Fiscal Year: 2013
    ..The R21 will comprise a comparison of two different devices for capturing peak cough airflow data to the more costly and technically demanding "gold standard" pneumotachograph protocol in the ..
  43. Accuracy of Examining Cough Function and its Relationship to Airway Protection
    CHRISTINE M contact SAPIENZA; Fiscal Year: 2010
    ..The R21 will comprise a comparison of two different devices for capturing peak cough airflow data to the more costly and technically demanding "gold standard" pneumotachograph protocol in the ..
  44. Innovative Interdisciplinary Approaches to Sustainable Airborne Infection Control
    Edward A Nardell; Fiscal Year: 2013
    ..to the airborne spread of DR TB will be to test the impact on TB transmission of active case finding through cough surveillance followed by rapid molecular testing and drug susceptibility testing that will allow patients to be ..
  45. Development of anti-human TL1A monoclonal antibody for the treatment of human ast
    Vadim V Deyev; Fiscal Year: 2010
    ..debilitating disease characterized by intermittent attacks of wheezing, shortness of breath, chest tightness, cough and excess sputum/mucus production...
  46. Airway mucus/mucin composition and proteome in COPD: A SPIROMICS ancillary study
    Mehmet Kesimer; Fiscal Year: 2013
    ..alterations produce a mucus that has an aberrant rheology, that is poorly transportable by normal ciliary and cough clearance mechanisms...
  47. Transmission and virulence of Mycobacterium tuberculosis
    Kathryn DeRiemer; Fiscal Year: 2010
    ..From enrolled study participants, we will obtain information, a cough sample with sputa, and a blood sample...
  48. SCCOR in Host Factors in Chronic Lung Disease
    Richard C Boucher; Fiscal Year: 2010
    ..Sheehan);Core D, Diagnostic Molecular Microbiology Core (M. Wolfgang);and Core E, Mucociliary and Cough Clearance by Gamma Scintigraphy Core (W. Bennett)...
  49. Vitamin D deficiency and the severity of bronchiolitis
    Jonathan M Mansbach; Fiscal Year: 2012
    ..or intensive care unit admission;2) the viral load of respiratory syncytial virus;and 3) the duration of cough and hospital length of stay...
  50. Developing an Automated Symptom Monitoring Device for Adolescents with Asthma
    Hyekyun Rhee; Fiscal Year: 2012
    ..valid and reliable monitoring of asthma symptoms based on the parameters of asthma symptoms including wheeze and cough;(2) To evaluate measurement accuracy and validity of ADAM;and (3) To evaluate the acceptability of ADAM by the ..
  51. Ontogeny of the Phase II cytosolic sulfotransferases and adverse drug reactions
    Ming Cheh Liu; Fiscal Year: 2013
    ..To verify this hypothesis, selected pediatric drugs that are commonly used for treating cough/cold and allergy/asthma symptoms in infants/children will be tested...
  52. Cell Phone Based Protocols for Diagnosis and Management of Childhood Pneumonia
    AMY GINSBURG; Fiscal Year: 2013
    ..of Childhood Illness protocol to identify children with pneumonia using a combination of symptoms, such as cough and fever. 2...
  53. PHARMACOGENOMICS OF INHALED CORTICOSTEROIDS TO REDUCE COPD EXACERBATIONS
    Craig P Hersh; Fiscal Year: 2013
    ..of chronic obstructive pulmonary disease (COPD), characterized by symptoms of worsening dyspnea, increased cough and sputum production, are troubling episodes for patients, leading them to seek medical care...
  54. Evaluation of Spinal Cord Stimulation Using Wire Leads to Restore an Effective Co
    Anthony F DiMarco; Fiscal Year: 2013
    ..account for significant morbidity and mortality in persons with spinal cord injury (SCI) due to their inability to cough an clear secretions...
  55. Development, Implementation and Evaluation of Novel Strategies to Reduce Inapprop
    JOSHUA P contact METLAY; Fiscal Year: 2010
    ..This acute cough management algorithm incorporates data on vital signs and symptoms distinguishing patients with community- ..
  56. Clinical Pharmacology/Mechanisms of Action of Emerging Abused Drugs (Club Drugs)
    Roland R Griffiths; Fiscal Year: 2013
    ..longer-acting compound dextromethorphan, which is a noncompetitive NMDA-antagonist found in over-the-counter cough and cold medications and abused at high doses as a hallucinogen...
  57. Rapid Estimation of Influenza Vaccine Effectiveness in a Wisconsin Population Coh
    Edward Belongia; Fiscal Year: 2010
    ..Patients with symptoms of feverishness, chills, or cough will be eligible...
  58. Effect of HIV Infection on Pulmonary MDR-TB Transmission and Virulence
    Ashwin S Dharmadhikari; Fiscal Year: 2013
    ..are potentially less infectious than HIV-uninfected MDR-TB patients by comparing their production of culturable cough aerosols and by comparing the infection rate of exposed sentinel guinea pigs after controlling for cough aerosol ..
  59. Mitochondrial reactive oxygen species induce airway sensory nerve activity
    THOMAS EDWARD TAYLOR-CLARK; Fiscal Year: 2013
    ..how local inflammation in the airways perverts vagal sensory C-fiber function, resulting in excessive and chronic cough, dyspnea, mucus secretion and bronchospasm in airway diseases including asthma, viral exacerbations and COPD...
  60. Chemokine Modulation of Airway Vagal Sensory Nerves
    CARL ROBERT POTENZIERI; Fiscal Year: 2011
    ..Activation of bronchopulmonary C-fibers results in the initiation of defensive reflexes such as urge to cough, dyspnea, and increased cholinergic output leading to mucus secretion and bronchoconstriction to aid in the ..
  61. Associations between laryngeal and cough dysfunction in bulbar amyotrophic latera
    Deanna Britton; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The ability to cough is essential component of pulmonary defenses...
  62. Regulation of Airway Protective Behaviors
    Teresa E Pitts; Fiscal Year: 2013
    ..goal of this project is to determine the role of tracheal and pharyngeal sensory feedback in the regulation of cough and swallow...
  63. Transmission and the respiratory tract in cryptosporidiosis
    Jeffrey Griffiths; Fiscal Year: 2007
    ..oocysts from induced sputum of children with acute or persistent diarrhea concurrently experiencing cough, with or without fast breathing...
  64. Effect of Pertussis Toxin on Cough in Guinea Pig
    NICHOLAS CARBONETTI; Fiscal Year: 2005
    Bordetella pertussis is a gram-negative bacterial pathogen that causes the disease known as pertussis or whooping cough. After respiratory tract infection by the bacteria, the disease is characterized by a severe and prolonged cough, ..
  65. Clinical Risk Factors for Barretts Esophagus in a Primary Care Setting
    Blair Jobe; Fiscal Year: 2009
    ..Dr. Jobe's group has systematically screened otolaryngology patients with cough and hoarseness for BE...
  66. Host-Pathogen Interactions in the Mammalian Airway
    Gill Diamond; Fiscal Year: 2006
    ..pertussis, the causative agent of whooping cough in humans...
  67. Photodynamic Therapy for the Treatment of Obstructive E*
    Todd Demmy; Fiscal Year: 2007
    ..Tumor response and symptom relief (cough, dyspnea, hemoptysis) will be determined at Day 5, one month and three months...
  68. Nitric Oxide and Chronic Rhinosinusitis
    Abraham Jacob; Fiscal Year: 2001
    ..are believed to result in mucosal disruption and hypersecretion, nasal obstruction, postnasal discharge, cough, headache, and facial pressure...
  69. Reflux Disease in Patients with Throat Signs/Symptoms
    Michael Vaezi; Fiscal Year: 2005
    ..Laryngoscopic examination of patients with symptoms of hoarseness, sore throat, throat clearing and chronic cough commonly shows laryngeal abnormalities including laryngitis and vocal cord lesions including polyps, granuloma and ..