cough

Summary

Summary: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.

Top Publications

  1. ncbi The diagnosis and management of chronic cough
    A H Morice
    Division of Academic Medicine, University of Hull, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire HU16 5JQ, UK
    Eur Respir J 24:481-92. 2004
  2. doi Chronic 'cough hypersensitivity syndrome': a more precise label for chronic cough
    K F Chung
    National Heart and Lung Institute, Imperial College, Dovehouse St, London SW3 6LY, UK
    Pulm Pharmacol Ther 24:267-71. 2011
  3. pmc Measurements of airborne influenza virus in aerosol particles from human coughs
    William G Lindsley
    Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States of America
    PLoS ONE 5:e15100. 2010
  4. pmc Diagnosis and management of cough executive summary: ACCP evidence-based clinical practice guidelines
    Richard S Irwin
    University of Massachusetts Medical School, Room S6 842, 55 Lake Ave North, Worcester, MA 01655, USA
    Chest 129:1S-23S. 2006
  5. ncbi Chronic wet cough: Protracted bronchitis, chronic suppurative lung disease and bronchiectasis
    A B Chang
    Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Pediatr Pulmonol 43:519-31. 2008
  6. ncbi Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough
    David A Groneberg
    Division of Allergy Research, Department of Pediatric Pneumology and Immunology, Charité Faculty of Medicine, Humboldt Universitat zu Berlin, Germany
    Am J Respir Crit Care Med 170:1276-80. 2004
  7. ncbi Prevalence of chronic obstructive pulmonary disease in China: a large, population-based survey
    Nanshan Zhong
    Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical College, 151 Yanjiang Road, Guangzhou, Guangdong 510120, China
    Am J Respir Crit Care Med 176:753-60. 2007
  8. ncbi ERS guidelines on the assessment of cough
    A H Morice
    Cardiovascular and Respiratory Studies, Respiratory Medicine, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire, and Imperial College London, UK
    Eur Respir J 29:1256-76. 2007
  9. pmc Neurogenesis of cough, other airway defensive behaviors and breathing: A holarchical system?
    Donald C Bolser
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA
    Respir Physiol Neurobiol 152:255-65. 2006
  10. ncbi The breathlessness, cough, and sputum scale: the development of empirically based guidelines for interpretation
    Nancy Kline Leidy
    Center for Health Outcomes Research, MEDTAP International Inc, 7101 Wisconsin Avenue, Suite 600, Bethesda, MD 20814, USA
    Chest 124:2182-91. 2003

Research Grants

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
  2. Quercetin and Innate Immune Responses in COPD
    Umadevi Sajjan; Fiscal Year: 2009
  3. Quercetin and Innate Immune Responses in COPD
    UMADEVI SIVANAPPA SAJJAN; Fiscal Year: 2010
  4. Real-Time Reagent-Free Noninvasive Diagnosis of Tuberculosis
    Payam Nahid; Fiscal Year: 2012
  5. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas A Platts Mills; Fiscal Year: 2010
  6. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas Platts Mills; Fiscal Year: 2009
  7. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas Platts Mills; Fiscal Year: 2006
  8. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas Platts Mills; Fiscal Year: 2009
  9. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas Platts Mills; Fiscal Year: 2007
  10. RECOMBINANT & LIVE ORAL SALMONELLA TYPHI HYBRID VACCINES
    Myron Levine; Fiscal Year: 2005

Detail Information

Publications330 found, 100 shown here

  1. ncbi The diagnosis and management of chronic cough
    A H Morice
    Division of Academic Medicine, University of Hull, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire HU16 5JQ, UK
    Eur Respir J 24:481-92. 2004
  2. doi Chronic 'cough hypersensitivity syndrome': a more precise label for chronic cough
    K F Chung
    National Heart and Lung Institute, Imperial College, Dovehouse St, London SW3 6LY, UK
    Pulm Pharmacol Ther 24:267-71. 2011
    Chronic cough remains a challenge to many clinicians because there is often no diagnostic link to causation, and because indirect antitussives are largely ineffective...
  3. pmc Measurements of airborne influenza virus in aerosol particles from human coughs
    William G Lindsley
    Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States of America
    PLoS ONE 5:e15100. 2010
    ..Nasopharyngeal swabs were collected from the volunteers and they were asked to cough three times into a spirometer...
  4. pmc Diagnosis and management of cough executive summary: ACCP evidence-based clinical practice guidelines
    Richard S Irwin
    University of Massachusetts Medical School, Room S6 842, 55 Lake Ave North, Worcester, MA 01655, USA
    Chest 129:1S-23S. 2006
  5. ncbi Chronic wet cough: Protracted bronchitis, chronic suppurative lung disease and bronchiectasis
    A B Chang
    Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Pediatr Pulmonol 43:519-31. 2008
    ..airways (endobronchial infection) in the causation of chronic respiratory symptoms, particularly chronic wet cough, has received very little attention over recent decades other than in the context of cystic fibrosis (CF)...
  6. ncbi Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough
    David A Groneberg
    Division of Allergy Research, Department of Pediatric Pneumology and Immunology, Charité Faculty of Medicine, Humboldt Universitat zu Berlin, Germany
    Am J Respir Crit Care Med 170:1276-80. 2004
    Transient receptor potential vanniloid-1 (TRPV-1) mediates the cough response induced by the pepper extract capsaicin and is expressed in sensory nerves that innervate the airway wall...
  7. ncbi Prevalence of chronic obstructive pulmonary disease in China: a large, population-based survey
    Nanshan Zhong
    Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical College, 151 Yanjiang Road, Guangzhou, Guangdong 510120, China
    Am J Respir Crit Care Med 176:753-60. 2007
    ..The prevalence of chronic obstructive pulmonary disease (COPD) in China is largely unknown...
  8. ncbi ERS guidelines on the assessment of cough
    A H Morice
    Cardiovascular and Respiratory Studies, Respiratory Medicine, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire, and Imperial College London, UK
    Eur Respir J 29:1256-76. 2007
  9. pmc Neurogenesis of cough, other airway defensive behaviors and breathing: A holarchical system?
    Donald C Bolser
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA
    Respir Physiol Neurobiol 152:255-65. 2006
    b>Cough and breathing are generated by a common muscular system. However, these two behaviors differ significantly in their mechanical features and regulation...
  10. ncbi The breathlessness, cough, and sputum scale: the development of empirically based guidelines for interpretation
    Nancy Kline Leidy
    Center for Health Outcomes Research, MEDTAP International Inc, 7101 Wisconsin Avenue, Suite 600, Bethesda, MD 20814, USA
    Chest 124:2182-91. 2003
    ..A patient report of respiratory symptoms in COPD is essential to successfully monitoring disease, adjusting treatment, and evaluating outcomes...
  11. ncbi Production of reflex cough by brainstem respiratory networks
    R Shannon
    Department of Physiology and Biophysics, MDC Box 8, University of South Florida Health Sciences Center, 12901 Bruce B Downs Blvd Tampa, FL 33612 4799, USA
    Pulm Pharmacol Ther 17:369-76. 2004
    Delineation of neural mechanisms involved in reflex cough is essential for understanding its many physiological and clinical complexities, and the development of more desirable antitussive agents...
  12. doi Detection of infectious influenza virus in cough aerosols generated in a simulated patient examination room
    John D Noti
    Health Effects Laboratory Division HELD, National Institute for Occupational Safety and Health NIOSH, Centers for Disease Control and Prevention CDC, Morgantown, WV, USA
    Clin Infect Dis 54:1569-77. 2012
    ....
  13. doi Cough hypersensitivity syndrome: a distinct clinical entity
    A H Morice
    Cardiovascular and Respiratory Studies, Castle Hill Hospital, Hull York Medical School, University of Hull, Castle Road, Cottingham, East Yorkshire HU16 5JQ, UK
    Lung 189:73-9. 2011
    We postulate that most patients with chronic cough have a single discrete clinical entity: cough hypersensitivity syndrome. We constructed a questionnaire that elicits the major components of the syndrome...
  14. doi Acoustic cough-reflux associations in chronic cough: potential triggers and mechanisms
    Jaclyn A Smith
    Respiratory Research Group, The University of Manchester, Manchester, UK
    Gastroenterology 139:754-62. 2010
    Central sensitization is thought to play a role in chronic cough and might explain the temporal association between cough and gastroesophageal reflux (GOR) in patients in whom non-GOR causes have been excluded...
  15. pmc Encoding of the cough reflex in anesthetized guinea pigs
    Brendan J Canning
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Physiol Regul Integr Comp Physiol 300:R369-77. 2011
    We have previously described the physiological and morphological properties of the cough receptors and their sites of termination in the airways and centrally in the nucleus tractus solitarius (nTS)...
  16. ncbi Acidification of the oesophagus acutely increases the cough sensitivity in patients with gastro-oesophageal reflux and chronic cough
    N Javorkova
    Department of Pathophysiology, Jessenius Faculty of Medicine, Martin, Slovakia
    Neurogastroenterol Motil 20:119-24. 2008
    Gastro-oesophageal reflux disease (GORD) is one of the most common causes of chronic cough; however, the mechanisms by which GOR initiates coughing are incompletely understood...
  17. doi Cough and sputum production are associated with frequent exacerbations and hospitalizations in COPD subjects
    Pierre Regis Burgel
    Service de Pneumologie, Hopital Cochin, Assistance Publique Hopitaux de Paris, 27 rue du Faubourg St Jacques, Paris Cedex 14, France
    Chest 135:975-82. 2009
    Epidemiologic studies indicate that chronic cough and sputum production are associated with increased mortality and disease progression in COPD subjects...
  18. ncbi Exhalation of respiratory viruses by breathing, coughing, and talking
    Sacha Stelzer-Braid
    Faculty of Science, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, NSW, Australia
    J Med Virol 81:1674-9. 2009
    ..In the subset of exhaled samples from 10 subjects examined by culture, infective rhinovirus was detected in 2. These data provide further evidence that breathing may be a source of respirable particles carrying infectious virus...
  19. ncbi Afferent neural pathways in cough and reflex bronchoconstriction
    J A Karlsson
    Pharmacological Laboratory, AB Draco, Lund, Sweden
    J Appl Physiol (1985) 65:1007-23. 1988
    b>Cough and bronchoconstriction are airway reflexes that protect the lung from inspired noxious agents. These two reflexes can be evoked both from the larynx and tracheobronchial tree and also from some extrarespiratory sites...
  20. doi Prevalence, pathogenesis, and causes of chronic cough
    Kian Fan Chung
    Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, UK
    Lancet 371:1364-74. 2008
    b>Cough is a reflex action of the respiratory tract that is used to clear the upper airways. Chronic cough lasting for more than 8 weeks is common in the community...
  21. pmc Increased tachykinin levels in induced sputum from asthmatic and cough patients with acid reflux
    Robert N Patterson
    Department of Medicine, Queen s University Belfast, and Regional Respiratory Centre, Belfast City Hospital, Grosvenor Road, Belfast BT12 6BJ, UK
    Thorax 62:491-5. 2007
    Acid reflux may aggravate airway disease including asthma and chronic cough. One postulated mechanism concerns a vagally-mediated oesophageal-tracheobronchial reflex with airway sensory nerve activation and tachykinin release.
  22. ncbi Flow dynamics and characterization of a cough
    J K Gupta
    National Air Transportation Center of Excellence for Research in the Intermodal Transport Environment RITE, School of Mechanical Engineering, Purdue University, West Lafayette, IN 47906 2088, USA
    Indoor Air 19:517-25. 2009
    Airborne disease transmission has always been a topic of wide interests in various fields for decades. Cough is found to be one of the prime sources of airborne diseases as it has high velocity and large quantity of droplets...
  23. pmc Identification of the tracheal and laryngeal afferent neurones mediating cough in anaesthetized guinea-pigs
    Brendan J Canning
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Physiol 557:543-58. 2004
    We have identified the tracheal and laryngeal afferent nerves regulating cough in anaesthetized guinea-pigs...
  24. pmc Weakly acidic reflux in patients with chronic unexplained cough during 24 hour pressure, pH, and impedance monitoring
    D Sifrim
    Faculty of Medicine, KU Leuven, Lab G I Physiopathology, O and N Gasthuisberg, 7th Floor, Herestraat 49, 3000, Leuven, Belgium
    Gut 54:449-54. 2005
    Acid gastro-oesophageal reflux is one of the most important causes of chronic cough. The response to acid suppression in these patients is not as good as in patients with heartburn but improvement with antireflux surgery has been ..
  25. ncbi Chronic idiopathic cough: a discrete clinical entity?
    Rubaiyat A Haque
    Airways Disease Section, National Heart and Lung Institute, Imperial College, Dovehouse St, London, SW3 6LY, UK
    Chest 127:1710-3. 2005
    Despite the success of specialist cough clinics, there is increasing recognition of a subgroup of chronic coughers in whom a diagnosis cannot be made even after thorough, systematic investigation...
  26. doi An algorithm for tuberculosis screening and diagnosis in people with HIV
    Kevin P Cain
    U S Centers for Disease Control and Prevention, Division of Tuberculosis Elimination, Atlanta, GA 30333, USA
    N Engl J Med 362:707-16. 2010
    ..No internationally accepted, evidence-based guideline addresses the optimal means of conducting such screening, although screening for chronic cough is common.
  27. doi Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough
    Antonio Grilo
    Unidad de Hipertension, Servicio de Medicina Interna, Hospital Universitario de Valme, Carretera de Cádiz S N bNeocodex, Avda, Charles Darwin, Acc A Seville, Spain
    Pharmacogenet Genomics 21:10-7. 2011
    ..Persistent cough is a common adverse reaction associated with ACEi, which can bind to the treatment cessation, but its etiology ..
  28. pmc Blood pressure changes alter tracheobronchial cough: computational model of the respiratory-cough network and in vivo experiments in anesthetized cats
    Ivan Poliacek
    Dept of Physiological Sciences, College of Veterinary Medicine, Univ of Florida, Gainesville, FL 32610, USA
    J Appl Physiol (1985) 111:861-73. 2011
    We tested the hypothesis, motivated in part by a coordinated computational cough network model, that alterations of mean systemic arterial blood pressure (BP) influence the excitability and motor pattern of cough...
  29. ncbi Distal esophagitis in patients with mustard-gas induced chronic cough
    M Ghanei
    Research Center for Chemical Injuries, Baqiyatallah University of Medical Sciences, Tehran, Iran
    Dis Esophagus 19:285-8. 2006
    ..In addition, they were suffering from asthma, chronic bronchitis and bronchiectasis. Bronchiolitis obliterans, along with other lung disorders, can be considered as contributors in the pathogenesis of esophagitis in MG exposed patients...
  30. ncbi Gabapentin in the treatment of intractable idiopathic chronic cough: case reports
    Sheldon Mintz
    Am J Med 119:e13-5. 2006
  31. doi Controversies in the evaluation and management of chronic cough
    Surinder S Birring
    King s College London, Division of Asthma, Allergy and Lung Biology, Denmark Hill, London SE5 9RS, UK
    Am J Respir Crit Care Med 183:708-15. 2011
    Chronic cough that cannot be explained after basic evaluation is a common reason for patients to be referred to respiratory outpatient clinics...
  32. doi Cough hypersensitivity syndrome is an important clinical concept: a pro/con debate
    Alyn H Morice
    Cardiovascular and Respiratory Studies, University of Hull, Hull York Medical School, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire HU16 5JQ, UK
    Lung 190:3-9. 2012
    The major etiologies of chronic cough are generally accepted to consist of upper airway cough syndrome (formerly postnasal drip syndrome), eosinophilic airway inflammation (asthma, nonasthmatic eosinophilic bronchitis), and ..
  33. pmc How respiratory muscle strength correlates with cough capacity in patients with respiratory muscle weakness
    Jung Hyun Park
    Department of Rehabilitation Medicine, Eulji University Hospital, Daejeon, Korea
    Yonsei Med J 51:392-7. 2010
    The purpose of this study is to investigate how respiratory muscle strength correlates to cough capacity in patients with respiratory muscle weakness.
  34. doi On the psychology of cough
    Omer Van den Bergh
    Health Psychology, University of Leuven, Tiensestraat 102, B 3000 Leuven, Belgium
    Lung 190:55-61. 2012
    Neurobiological research is increasingly documenting the role of higher brain areas in cough, but little systematic behavioral research on the role of psychological factors exists...
  35. pmc Comparison of symptoms and treatment outcomes between actively and passively detected tuberculosis cases: the additional value of active case finding
    S den Boon
    Desmond Tutu TB Centre, Stellenbosch University, South Africa
    Epidemiol Infect 136:1342-9. 2008
    ..01, CI 0.33-3.09). Passively detected cases reported the presence of the symptoms cough (OR 3.72, 95% CI 1.47-9.39), haemoptysis (OR 3.20, 95% CI 1.03-9.93), night sweats (OR 3.35, 95% CI 1.40-7...
  36. pmc Volitional control of reflex cough
    Karen W Hegland
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA
    J Appl Physiol (1985) 113:39-46. 2012
    Multiple studies suggest a role for the cerebral cortex in the generation of reflex cough in awake humans...
  37. ncbi Clinical, physiological and anti-inflammatory effect of montelukast in patients with cough variant asthma
    Masaya Takemura
    Departments of Respiratory Medicine, Kyoto University, Kyoto, Japan
    Respiration 83:308-15. 2012
    b>Cough variant asthma (CVA) is a phenotype of asthma presenting solely with coughing, characterized by airway hyperresponsiveness, eosinophilic inflammation and a cough response to bronchodilators...
  38. doi Functional implications of the multiple afferent pathways regulating cough
    Brendan J Canning
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Pulm Pharmacol Ther 24:295-9. 2011
    ..of capsaicin-sensitive C-fibers innervating these airways will also produce coughing, but C-fiber dependent cough is prevented entirely by anesthesia...
  39. doi Chronic refractory cough as a sensory neuropathy: evidence from a reinterpretation of cough triggers
    Anne E Vertigan
    Department of Speech Pathology, John Hunter Hospital, Newcastle, Australia
    J Voice 25:596-601. 2011
    The aims of this study were to examine cough triggers in individuals with chronic cough (CC), identify sensory symptoms consistent with central reflex sensitization (paresthesia and allotussia), and interpret this information in relation ..
  40. doi Voluntary and reflex cough and the expiration reflex; implications for aspiration after stroke
    J G Widdicombe
    Univ London, 116 Pepys Road, London SW208NY, UK
    Pulm Pharmacol Ther 24:312-7. 2011
    Aspiration is a common result of stroke, and may lead to lung infections and pneumonia. Cough may prevent this aspiration and thus prevent the pneumonia...
  41. pmc Cough: an unmet clinical need
    Peter V Dicpinigaitis
    Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10461, USA
    Br J Pharmacol 163:116-24. 2011
    b>Cough is among the most common complaints for which patients worldwide seek medical attention. Thus, the evaluation and treatment of cough result in tremendous financial expenditure and consumption of health care resources...
  42. ncbi Nonacid reflux episodes reaching the pharynx are important factors associated with cough
    Neil Patterson
    Department of Medicine, Royal Hospitals, Grosvenor Road, Belfast, UK
    J Clin Gastroenterol 43:414-9. 2009
    Gastroesophageal reflux is implicated in the pathogenesis of asthma and chronic cough. To date most studies have focused on acid reflux measured by pH below the upper esophageal sphincter (UES)...
  43. doi Pepsin and bile acids in induced sputum of chronic cough patients
    Marcin Grabowski
    Department of Internal Medicine, Geriatrics and Allergology, Wroclaw Medical University, Wroclaw, Poland
    Respir Med 105:1257-61. 2011
    One of the theories which explain, why gastroesophageal reflux disease (GORD) may provoke cough, is the occurrence of aspiration of gastric content into the airways...
  44. pmc TRPA1 agonists evoke coughing in guinea pig and human volunteers
    Mark A Birrell
    Respiratory Pharmacology Group, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Am J Respir Crit Care Med 180:1042-7. 2009
    b>Cough is the most frequent reason for consultation with a family doctor, or with a general or respiratory physician. Treatment options are limited and one meta-analysis concluded that over-the-counter remedies are ineffective...
  45. ncbi Incidence of chronic obstructive pulmonary disease in a cohort of young adults according to the presence of chronic cough and phlegm
    Roberto de Marco
    Sezione di Epidemiologia and Statistica Medica, Dipartimento di Medicina e Sanita Pubblica, Universita degli Studi di Verona, c o Istituti Biologici II, Strada Le Grazie 8 37134, Verona, Italy
    Am J Respir Crit Care Med 175:32-9. 2007
    The few prospective studies aimed at assessing the incidence of chronic obstructive pulmonary disease (COPD) in relation to the presence of chronic cough/phlegm have produced contrasting results.
  46. doi Antibiotic use and health-seeking behaviour in an underprivileged area of Perú
    C Kristiansson
    Department of Public Health Science, Division of International Health IHCAR, Karolinska Institutet, Stockholm, Sweden
    Trop Med Int Health 13:434-41. 2008
    ..To describe the health-seeking behaviour and use of antibiotics in the urban community of Yurimaguas in the Amazonian area of Peru...
  47. ncbi Chronic cough due to gastroesophageal reflux disease: failure to resolve despite total/near-total elimination of esophageal acid
    Richard S Irwin
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Chest 121:1132-40. 2002
    While medical therapy may fail to improve cough due to gastroesophageal reflux disease (GERD), it is not known if inadequate esophageal acid suppression is responsible.
  48. ncbi Vagal afferent nerves regulating the cough reflex
    Brendan J Canning
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Respir Physiol Neurobiol 152:223-42. 2006
    ..All afferent nerve subtypes innervating the airways can modulate the cough reflex...
  49. pmc Abnormal oesophageal motility in patients with chronic cough
    J A Kastelik
    Division of Academic Medicine, Postgraduate Medical Institute, University of Hull, Hull, UK
    Thorax 58:699-702. 2003
    Although gastro-oesophageal reflux is a recognised cause of chronic cough, the role of oesophageal dysmotility is unknown...
  50. pmc Detecting patients at a high risk of developing chronic obstructive pulmonary disease in general practice: cross sectional case finding study
    C P van Schayck
    Department of General Practice, Research Institute ExTra, University of Maastricht, Postbox 616, 6200 MD Maastricht, Netherlands
    BMJ 324:1370. 2002
    ..To investigate the effectiveness of case finding of patients at risk of developing chronic obstructive pulmonary disease, whether the method is suitable for use in general practice, how patients should be selected, and the time required...
  51. doi Sex differences and predictors of objective cough frequency in chronic cough
    A Kelsall
    Education and Research Centre, Wythenshawe Hospital, Manchester, UK
    Thorax 64:393-8. 2009
    Women are consistently over-represented in specialist cough clinics and known to have a more sensitive cough reflex than men. Whether female sex and other patient characteristics are associated with higher cough rates is not known...
  52. pmc Headaches precipitated by cough, prolonged exercise or sexual activity: a prospective etiological and clinical study
    Julio Pascual
    Service of Neurology, University Hospital of Salamanca, 37007, Salamanca, Spain
    J Headache Pain 9:259-66. 2008
    Headaches provoked by cough, prolonged physical exercise and sexual activity have not been studied prospectively, clinically and neuroradiologically...
  53. ncbi Sex-related differences in cough reflex sensitivity in patients with chronic cough
    Jack A Kastelik
    Academic Department of Medicine, University of Hull, Castle Hill Hospital, Cottingham, United Kingdom
    Am J Respir Crit Care Med 166:961-4. 2002
    Among patients attending specialist cough clinics there is an excess of females, but the reason for this sex difference is unknown...
  54. ncbi Chronic cough and phlegm in young adults
    I Cerveri
    Division of Respiratory Diseases, IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy
    Eur Respir J 22:413-7. 2003
    The Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines underline that the presence of chronic cough and sputum production before airflow obstruction offers a unique opportunity to identify subjects at risk of ..
  55. ncbi Involvement of P2X receptor subtypes in ATP-induced enhancement of the cough reflex sensitivity
    Junzo Kamei
    Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Pharmacol 528:158-61. 2005
    ..These results suggest that although ATP, by itself, does not elicit spontaneous coughs, it likely enhances the cough reflex sensitivity...
  56. ncbi Effect of tartaric acid-induced cough on pulmonary function in normal and asthmatic humans
    W Robert Addington
    Brevard Rehabilitation Medicine, Melbourne, Florida, USA
    Am J Phys Med Rehabil 82:374-8. 2003
    The laryngeal cough reflex and the laryngeal cough expiratory reflex are brainstem reflexes that protect the upper airway from significant aspiration...
  57. doi New insights in cough
    Ashley Woodcock
    University Hospital of South Manchester, Southmoor Road, Manchester, UK
    Br Med Bull 96:61-73. 2010
    Chronic cough is common, blights patients' lives and is hard to treat. Chronic cough patients demonstrate high objective cough rates and as a group have increased cough reflex sensitivity...
  58. pmc A schlieren optical study of the human cough with and without wearing masks for aerosol infection control
    Julian W Tang
    Department of Laboratory Medicine, National University of Singapore, Singapore
    J R Soc Interface 6:S727-36. 2009
    ..Further, a high-speed schlieren video of a single cough is analysed by a computerized method of tracking individual turbulent eddies, demonstrating the non-intrusive ..
  59. ncbi Vital-sign abnormalities as predictors of pneumonia in adults with acute cough illness
    Brendon R Nolt
    The Center for Health Equity Research and Promotion, VA Medical Center and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Am J Emerg Med 25:631-6. 2007
    This study examines the strength of the association between vital-sign abnormalities, advanced age, and the diagnosis of community-acquired pneumonia (CAP) in the evaluation of adults with acute cough illness.
  60. ncbi Cough as a symptom
    K F Chung
    Pulm Pharmacol Ther 17:329-32. 2004
    The Third International Symposium on Cough focused on acute and chronic cough, both clinical and basic science...
  61. ncbi Exhaled nitric oxide in evaluation of young adults with chronic cough
    Krzysztof Kowal
    Department of Allergology and Internal Medicine, Medical University of Bialystok, Poland
    J Asthma 46:692-8. 2009
    Bronchial asthma (A) is frequently diagnosed in patients with chronic cough. The study was conducted to determine whether an evaluation of fractional exhaled nitric oxide (FeNO) concentration can be used as a screening test for asthma in ..
  62. pmc Randomised clinical trial: high-dose acid suppression for chronic cough - a double-blind, placebo-controlled study
    N J Shaheen
    Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, 27599 7080, USA
    Aliment Pharmacol Ther 33:225-34. 2011
    b>Cough may be a manifestation of gastro-oesophageal reflux disease (GERD). The utility of acid suppression in GERD-related cough is uncertain.
  63. ncbi Chronic cough as a sign of laryngeal sensory neuropathy: diagnosis and treatment
    Bryant Lee
    Department of Otolaryngology Head and Neck Surgery, The Grabscheid Voice Center, Mount Sinai Medical Center, One Gustave L Levy Place, New York, NY 10029, USA
    Ann Otol Rhinol Laryngol 114:253-7. 2005
    Chronic cough is often attributed to reflux, postnasal drip, or asthma. We present 28 patients who had chronic cough or throat-clearing as a manifestation of sensory neuropathy involving the superior or recurrent laryngeal nerve...
  64. ncbi Clinical history in gastroesophageal cough
    Caroline F Everett
    Academic Department of Medicine, Institute of Postgraduate Medicine, University of Hull, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire, UK
    Respir Med 101:345-8. 2007
    Gastroesophageal disease, a common cause of chronic cough, is often poorly recognised. We reviewed the presenting history of 47 chronic cough patients who had been proven to have gastroesophageal disease by oesophageal function testing...
  65. pmc Barriers to accessing TB diagnosis for rural-to-urban migrants with chronic cough in Chongqing, China: a mixed methods study
    Qian Long
    School of Public Health, Chongqing Medical University, No 1 Yixueyuan Road, Chongqing, PR China
    BMC Health Serv Res 8:202. 2008
    ..seeking behaviour of and health systems responses to migrants and permanent urban residents suffering from chronic cough, in order to identify the factors influencing delays for both groups in receiving a TB diagnosis in urban China.
  66. doi Angiotensin-converting enzyme inhibitor associated cough: deceptive information from the Physicians' Desk Reference
    Sripal Bangalore
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Med 123:1016-30. 2010
    Dry cough is a common, annoying adverse effect of all angiotensin-converting enzyme (ACE) inhibitors...
  67. doi Desensitization of the cough reflex by exercise and voluntary isocapnic hyperpnea
    Federico Lavorini
    Department of Internal Medicine, Respiratory Medicine and Cell Therapy, University of Florence, Florence, Italy
    J Appl Physiol (1985) 108:1061-8. 2010
    ..The threshold for the cough reflex induced by inhalation of increasing nebulizer outputs of ultrasonically nebulized distilled water (fog), an ..
  68. pmc Variation in antibiotic prescribing and its impact on recovery in patients with acute cough in primary care: prospective study in 13 countries
    C C Butler
    Department of Primary Care and Public Health, School of Medicine, Cardiff University, Cardiff CF14 4XN, Wales
    BMJ 338:b2242. 2009
    To describe variation in antibiotic prescribing for acute cough in contrasting European settings and the impact on recovery.
  69. doi Molecular characterization and distinguishing features of a novel human rhinovirus (HRV) C, HRVC-QCE, detected in children with fever, cough and wheeze during 2003
    K E Arden
    Sir Albert Sakzewski Virus Research Centre, Queensland Children s Medical Research Institute, Royal Children s Hospital, Queensland, Australia
    J Clin Virol 47:219-23. 2010
    ....
  70. ncbi Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents
    Ian M Paul
    Department of Pediatrics, Division of General Pediatrics, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033 0850, USA
    Pediatrics 114:e85-90. 2004
    ..medications dextromethorphan and diphenhydramine are superior to placebo for the treatment of nocturnal cough and sleep difficulty associated with upper respiratory infections and to determine whether parents have improved ..
  71. ncbi Angiotensin-converting enzyme-related cough among Chinese-Americans
    Daniel S Tseng
    Department of Medicine, Kaiser Permanente of Northern California, Santa Clara, USA
    Am J Med 123:183.e11-5. 2010
    ..We investigated the perception that Chinese-Americans may have a higher incidence of chronic cough from angiotensin-converting enzyme inhibitors.
  72. pmc Sensitivity and specificity of fluorescence microscopy for diagnosing pulmonary tuberculosis in a high HIV prevalence setting
    A Cattamanchi
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, California, USA
    Int J Tuberc Lung Dis 13:1130-6. 2009
    ..Mulago Hospital, Kampala, Uganda...
  73. ncbi Chronic cough and phlegm in young adults: should we worry?
    Jørgen Vestbo
    Am J Respir Crit Care Med 175:2-3. 2007
  74. ncbi Chronic cough: eosinophilic bronchitis without asthma
    P G Gibson
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Lancet 1:1346-8. 1989
    Sputum cell-counts were studied in 7 non-smokers with corticosteroid-responsive chronic cough productive of sputum and 8 smokers with a clinical diagnosis of chronic bronchitis, all of whom had normal lung function tests and methacholine ..
  75. ncbi Controlled comparison between betamethasone gel and lidocaine jelly applied over tracheal tube to reduce postoperative sore throat, cough, and hoarseness of voice
    P A Sumathi
    Department of Anaesthesiology, Kasturba Medical College, Manipal 576104, India
    Br J Anaesth 100:215-8. 2008
    Postoperative sore throat, cough, and hoarseness of voice though minor sequelae after general tracheal anaesthesia can be distressing to the patient.
  76. doi High frequency of chronic cough and sputum production with lowered exercise capacity in young smokers
    Anna Hamari
    Department of Medicine, Pulmonary Division, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
    Ann Med 42:512-20. 2010
    ..The aim was to evaluate how cigarette smoking is associated with respiratory symptoms, fitness, and anthropometric measures in young smokers...
  77. ncbi Suppression of cough during emergence from general anesthesia: laryngotracheal lidocaine through a modified endotracheal tube
    C A Diachun
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305 5640, USA
    J Clin Anesth 13:447-51. 2001
    ..To ascertain if coughing during emergence from general anesthesia can be suppressed with a modified endotracheal tube...
  78. ncbi Complications of cough: ACCP evidence-based clinical practice guidelines
    Richard S Irwin
    University of Massachusetts Medical School, Room S6 842, 55 Lake Ave North, Worcester, MA 01655, USA
    Chest 129:54S-58S. 2006
    ..To review the spectrum and frequency of complications associated with coughing...
  79. pmc Systematic review and meta-analysis of randomised controlled trials of gastro-oesophageal reflux interventions for chronic cough associated with gastro-oesophageal reflux
    A B Chang
    Department of Respiratory Medicine, Royal Children s Hospital, Herston, Brisbane, QLD 4029, Australia
    BMJ 332:11-7. 2006
    To evaluate the efficacy of treatment for gastro-oesophageal reflux disease (GORD) on chronic cough in children and adults without an underlying respiratory disease.
  80. ncbi The size and concentration of droplets generated by coughing in human subjects
    Shinhao Yang
    Department of Environmental and Occupational Health, Toko University, Taiwan, Republic of China
    J Aerosol Med 20:484-94. 2007
    ..Comparison of the droplet concentrations for subjects in different age groups demonstrated that subjects in the 30-50-year age group have the largest droplet concentrations...
  81. ncbi Clinical signs and symptoms predicting influenza infection
    A S Monto
    University of Michigan, 3080 SPH 1, 109 Observatory St, Ann Arbor, MI 48109 2029, USA
    Arch Intern Med 160:3243-7. 2000
    ..In clinical practice, antiviral use has rarely been guided by antecedent laboratory diagnosis. Defined clinical predictors of an influenza infection can help guide timely therapy and avoid unnecessary antibiotic use...
  82. pmc Development and validation of a clinical prediction rule for angiotensin-converting enzyme inhibitor-induced cough
    Takeshi Morimoto
    Division of General Internal Medicine and Primary Care, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Gen Intern Med 19:684-91. 2004
    Angiotensin-converting enzyme inhibitors are effective for many cardiovascular diseases and are widely prescribed, but cough sometimes necessitates their withdrawal.
  83. pmc Exhaled droplets due to talking and coughing
    Xiaojian Xie
    Department of Mechanical Engineering, University of Hong Kong, Pokfulam Road, Hong Kong SAR, People s Republic of China
    J R Soc Interface 6:S703-14. 2009
    ..Smaller droplets were also detected by the aerosol spectrometer. More droplets seemed to be generated when a food dye was used...
  84. pmc Cough suppression during flexible bronchoscopy using combined sedation with midazolam and hydrocodone: a randomised, double blind, placebo controlled trial
    D Stolz
    Division of Respiratory Medicine and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland
    Thorax 59:773-6. 2004
    ..A randomised, placebo controlled, double blind study was undertaken to determine whether hydrocodone in combination with midazolan improves cough suppression during FB without increasing the risk of desaturation.
  85. ncbi Intravenous dexamethasone pretreatment reduces fentanyl-induced cough
    Jui An Lin
    Department of Anesthesiology, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    J Formos Med Assoc 106:649-55. 2007
    Fentanyl is regularly used in clinical anesthesia practice but fentanyl-induced cough (FIC) will sometimes bother anesthesiologists. This study was designed to examine the effect of intravenous (IV) dexamethasone (DEX) on FIC.
  86. ncbi Anatomy and neurophysiology of the cough reflex: ACCP evidence-based clinical practice guidelines
    Brendan J Canning
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Chest 129:33S-47S. 2006
    To describe the anatomy and neurophysiology of the cough reflex.
  87. pmc Medullary respiratory neurones and control of laryngeal motoneurones during fictive eupnoea and cough in the cat
    D M Baekey
    Department of Physiology and Biophysics, University of South Florida Health Sciences Center, 12901 Bruce B. Downs Boulevard, Tampa, FL 33612-4799, USA
    J Physiol 534:565-81. 2001
    ..2. Data were obtained from 28 mid-collicular decerebrated, artificially ventilated cats. Cough-like motor patterns (fictive cough) in phrenic, lumbar and recurrent laryngeal nerves were elicited by mechanical ..
  88. pmc Acid-sensitive vagal sensory pathways and cough
    Marian Kollarik
    The Johns Hopkins School of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    Pulm Pharmacol Ther 20:402-11. 2007
    Acid is an important mediator in the pathogenesis of cough. Inhalation of exogenous acid triggers cough and endogenous acid may contribute to cough in respiratory diseases...
  89. ncbi Effective antitussives for the cough patient: an unmet need
    K F Chung
    National Heart and Lung Institute, Imperial College London and Royal Brompton and Harefield NHS Trust, London SW3, UK
    Pulm Pharmacol Ther 20:438-45. 2007
    Chronic cough is a prevalent symptom in the community but it is likely that only a small fraction of chronic coughers seek medical attention...
  90. ncbi Excess mortality and tuberculosis among individuals with prolonged cough: a population-based study from Vietnam
    N P Hoa
    Department of Public Health Sciences, Division of International Health IHCAR, Karolinska Institutet, Stockholm, Sweden
    Int J Tuberc Lung Dis 10:851-6. 2006
    ..A demographic surveillance site in north-west Vietnam...
  91. pmc Mechanisms of pelvic floor muscle function and the effect on the urethra during a cough
    Ruth C Lovegrove Jones
    Palo Alto Veterans Administration Medical Centre and Department of Urology, Stanford University School of Medicine, Stanford, CA 94304 1290, USA
    Eur Urol 57:1101-10. 2010
    ..Current measurement tools have difficulty identifying the automatic physiologic processes maintaining continence, and many questions still remain about pelvic floor muscle (PFM) function during automatic events...
  92. pmc The cough reflex in animals: relevance to human cough research
    Brendan J Canning
    Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    Lung 186:S23-8. 2008
    All mammalian species studied cough or display some similar respiratory reflex upon aerosol challenge with tussigenic stimuli such as citric acid or capsaicin...
  93. pmc Comparison of PCR for sputum samples obtained by induced cough and serological tests for diagnosis of Mycoplasma pneumoniae infection in children
    Tsutomu Yamazaki
    Department of Pediatrics, Saitama Medical School, Morohongo 38, Moroyama, Iruma, 350 0495 Japan
    Clin Vaccine Immunol 13:708-10. 2006
    ..The sensitivity and specificity of PA were 80.3% and 92.3% at a titer of 1:80. ELISA was found to be less sensitive than PA...
  94. ncbi Supramedullary influences on cough
    John Widdicombe
    University of London, 116 Pepys Road, London SW20 8NY, UK
    Respir Physiol Neurobiol 152:320-8. 2006
    The evidence for supramedullary influences on cough is largely indirect. Cough can be voluntarily induced or inhibited, functions usually thought to reside in the cerebral cortex...
  95. ncbi Irritant-induced chronic cough: irritant-induced TRPpathy
    Stuart M Brooks
    Colleges of Public Health, University of South Florida, Tampa, FL 33612, USA
    Lung 186:S88-93. 2008
    This article expands the author's presentation at the First American Cough Conference in New York City, June 8-9, 2007. The results of a scientific literature search and application of personal research findings are included...
  96. pmc Central regulation of the cough reflex: therapeutic implications
    Brendan J Canning
    Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    Pulm Pharmacol Ther 22:75-81. 2009
    ..Both of these classes of drugs act centrally to prevent cough. A brief review of what is known about the central encoding of cough is presented, as are the advantages of ..
  97. ncbi Assessment of the cough reflex after propofol anaesthesia for colonoscopy
    J Guglielminotti
    Service d Anesthésiologie et de Réanimation Chirurgicale, Hopital Bichat, Assistance Publique, Hopitaux de Paris, 46 rue Henri Huchard, F 75018 Paris, France
    Br J Anaesth 95:406-9. 2005
    Dysfunction of the cough reflex as a result of the lingering effects of anaesthetics may lead to aspiration pneumonia or retained secretions after general anaesthesia...
  98. doi Pharmacology of cough and cold medicines
    Teri Woo
    University of Portland, School of Nursing, Kaiser Permanente, OR, USA
    J Pediatr Health Care 22:73-9; quiz 80-2. 2008
  99. pmc Health seeking behaviour, health system experience and tuberculosis case finding in Gambians with cough
    Yaya Kasse
    Tuberculosis Division, Medical Research Council Laboratories, Banjul, The Gambia
    BMC Public Health 6:143. 2006
    ..We aimed to study health-seeking behaviour and experience of those with cough in The Gambia and to identify whether they had tuberculosis.
  100. ncbi Fog-induced cough with impaired respiratory sensation in congenital central hypoventilation syndrome
    Federico Lavorini
    Dipartimento di Area Critica Medico Chirurgica, Sezione di Medicina Respiratoria, Universita degli Studi di Firenze, Viale G B Morgagni, 85 50134 Florence, Italy
    Am J Respir Crit Care Med 176:825-32. 2007
    ..Little is known regarding cough in CCHS...
  101. pmc Idiopathic chronic cough: association with organ specific autoimmune disease and bronchoalveolar lymphocytosis
    S S Birring
    Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK
    Thorax 58:1066-70. 2003
    We have recently reported a strong association between organ specific autoimmune disease and idiopathic chronic cough and have suggested that cough may be caused by airway inflammation secondary to aberrant homing of activated ..

Research Grants75

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Dextromethorphan is approved for use as a cough medicine, but it has not been studied to see if it can help in diabetic macular edema...
  2. Quercetin and Innate Immune Responses in COPD
    Umadevi Sajjan; Fiscal Year: 2009
    ..kaempferol) has been positively associated with pulmonary function (FEV1) and inversely associated with chronic cough and breathlessness in Dutch COPD patients (6)...
  3. Quercetin and Innate Immune Responses in COPD
    UMADEVI SIVANAPPA SAJJAN; Fiscal Year: 2010
    ..kaempferol) has been positively associated with pulmonary function (FEV1) and inversely associated with chronic cough and breathlessness in Dutch COPD patients (6)...
  4. Real-Time Reagent-Free Noninvasive Diagnosis of Tuberculosis
    Payam Nahid; Fiscal Year: 2012
    ..tuberculosis from TB suspects. Patient cough aerosol analysis for M. tuberculosis has the potential to address all these requirements...
  5. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas A Platts Mills; Fiscal Year: 2010
    ..Project 4: Mechanisms of pH deviation in asthma and chronic cough: Using new methods of measuring exhaled breath pH, the studies will focus on distinguishing between patients with ..
  6. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas Platts Mills; Fiscal Year: 2009
    ..Project 4: Mechanisms of pH deviation in asthma and chronic cough: Using new methods of measuring exhaled breath pH, the studies will focus on distinguishing between patients with ..
  7. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas Platts Mills; Fiscal Year: 2006
    ..Project 4: Mechanisms of pH deviation in asthma and chronic cough: Using new methods of measuring exhaled breath pH, the studies will focus on distinguishing between patients with ..
  8. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas Platts Mills; Fiscal Year: 2009
    ..Project 4: Mechanisms of pH deviation in asthma and chronic cough: Using new methods of measuring exhaled breath pH, the studies will focus on distinguishing between patients with ..
  9. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas Platts Mills; Fiscal Year: 2007
    ..Project 4: Mechanisms of pH deviation in asthma and chronic cough: Using new methods of measuring exhaled breath pH, the studies will focus on distinguishing between patients with ..
  10. RECOMBINANT & LIVE ORAL SALMONELLA TYPHI HYBRID VACCINES
    Myron Levine; Fiscal Year: 2005
    ..The clinical syndrome began with fever, dry cough, myalgia and sore throat and progressed to atypical pneumonia...
  11. RECOMBINANT & LIVE ORAL SALMONELLA TYPHI HYBRID VACCINES
    Myron Levine; Fiscal Year: 2006
    ..The clinical syndrome began with fever, dry cough, myalgia and sore throat and progressed to atypical pneumonia...
  12. RECOMBINANT & LIVE ORAL SALMONELLA TYPHI HYBRID VACCINES
    Myron Levine; Fiscal Year: 2007
    ..The clinical syndrome began with fever, dry cough, myalgia and sore throat and progressed to atypical pneumonia...
  13. RECOMBINANT & LIVE ORAL SALMONELLA TYPHI HYBRID VACCINES
    Myron Levine; Fiscal Year: 2004
    ..The clinical syndrome began with fever, dry cough, myalgia and sore throat and progressed to atypical pneumonia...
  14. SCCOR in Host Factors in Chronic Lung Disease
    Richard Boucher; Fiscal Year: 2006
    ..Sheehan); Core D, Diagnostic Molecular Microbiology Core (M. Wolfgang); and Core E, Mucociliary and Cough Clearance by Gamma Scintigraphy Core (W. Bennett)...
  15. SCCOR in Host Factors in Chronic Lung Disease
    Richard Boucher; Fiscal Year: 2009
    ..Sheehan);Core D, Diagnostic Molecular Microbiology Core (M. Wolfgang);and Core E, Mucociliary and Cough Clearance by Gamma Scintigraphy Core (W. Bennett)...
  16. ADENYLATE CYCLASE TOXIN FROM BORDETELLA PERTUSSIS
    H Masure; Fiscal Year: 1992
    Bordetella pertussis, is a worldwide pathogen which causes whooping cough in children and persistent bronchitis in adults who probably serve as the natural reservoir...
  17. SCCOR in Host Factors in Chronic Lung Disease
    Richard Boucher; Fiscal Year: 2007
    ..Sheehan); Core D, Diagnostic Molecular Microbiology Core (M. Wolfgang); and Core E, Mucociliary and Cough Clearance by Gamma Scintigraphy Core (W. Bennett)...
  18. IRON ACQUISITION IN BORDETELLA PERTUSSIS
    SANDRA KAY ARMSTRONG; Fiscal Year: 2010
    ..B. pertussis is the agent that colonizes the human respiratory epithelium to cause whooping cough, or pertussis, and B. bronchiseptica infects a wide range of nonhuman mammals. For iron retrieval, B...
  19. Neurotrophin Regulation of the Airway Parasympathetic Nervous System
    Allen Myers; Fiscal Year: 2009
    ..such as NGF, are increased in the inflamed or infected airways and many symptoms of these diseases (hyperactivity, cough, mucous production) may be related to altered or aberrant functions of the airway nervous system as seen in asthma,..
  20. Infant Study of Inhaled Saline in Cystic Fibrosis (ISIS) - CCC - Lead Application
    Margaret Rosenfeld; Fiscal Year: 2009
    ..endpoints will include changes in weight and height, resting respiratory rate and oximetry, a standardized cough score, and symptoms by parental home report...
  21. Transmission and the respiratory tract in cryptosporidiosis
    Jeffrey Griffiths; Fiscal Year: 2007
    ..oocysts from induced sputum of children with acute or persistent diarrhea concurrently experiencing cough, with or without fast breathing...
  22. Computational and Cell Culture Models for Mucus Clearance
    Richard Superfine; Fiscal Year: 2009
    ..The latter is operative during effective clearance maneuvers such as cough, and it is understood that even in the absence of cilia propulsion, cough can maintain sterile airways...
  23. Computational and Cell Culture Models for Mucus Clearance
    Richard Superfine; Fiscal Year: 2010
    ..The latter is operative during effective clearance maneuvers such as cough, and it is understood that even in the absence of cilia propulsion, cough can maintain sterile airways...
  24. Transmission and the respiratory tract in cryptosporidiosis
    Jeffrey Griffiths; Fiscal Year: 2006
    ..oocysts from induced sputum of children with acute or persistent diarrhea concurrently experiencing cough, with or without fast breathing...
  25. CT Diagnosis of Tracheomalacia in Patients with COPD
    Phillip Boiselle; Fiscal Year: 2009
    ..Chronic cough is the fifth most common symptom for which patients seek medical care in the United States, accounting for more ..
  26. GENETIC ALTERATIONS AT MULTIPLE LOCI IN PRE-INVASIVE BRONCHIAL LESIONS
    Marshall Anderson; Fiscal Year: 2000
    ..Currently, the diagnosis of lung cancer relies on the symptoms of cough, hemoptysis and production of sputum, and the conventional chest x- ray...
  27. GENETIC ALTERATIONS AT MULTIPLE LOCI IN PRE-INVASIVE BRONCHIAL LESIONS
    Marshall Anderson; Fiscal Year: 2001
    ..Currently, the diagnosis of lung cancer relies on the symptoms of cough, hemoptysis and production of sputum, and the conventional chest x- ray...
  28. GENETIC ALTERATIONS AT MULTIPLE LOCI IN PRE-INVASIVE BRONCHIAL LESIONS
    Marshall Anderson; Fiscal Year: 1999
    ..Currently, the diagnosis of lung cancer relies on the symptoms of cough, hemoptysis and production of sputum, and the conventional chest x- ray...
  29. GENETIC ALTERATIONS AT MULTIPLE LOCI IN PRE-INVASIVE BRONCHIAL LESIONS
    Marshall Anderson; Fiscal Year: 2001
    ..Currently, the diagnosis of lung cancer relies on the symptoms of cough, hemoptysis and production of sputum, and the conventional chest x- ray...
  30. GENETIC ALTERATIONS AT MULTIPLE LOCI IN PRE-INVASIVE BRONCHIAL LESIONS
    Marshall Anderson; Fiscal Year: 2001
    ..Currently, the diagnosis of lung cancer relies on the symptoms of cough, hemoptysis and production of sputum, and the conventional chest x- ray...
  31. GENETIC ALTERATIONS AT MULTIPLE LOCI IN PRE-INVASIVE BRONCHIAL LESIONS
    Marshall Anderson; Fiscal Year: 1999
    ..Currently, the diagnosis of lung cancer relies on the symptoms of cough, hemoptysis and production of sputum, and the conventional chest x- ray...
  32. GENETIC ALTERATIONS AT MULTIPLE LOCI IN PRE-INVASIVE BRONCHIAL LESIONS
    Marshall Anderson; Fiscal Year: 2002
    ..Currently, the diagnosis of lung cancer relies on the symptoms of cough, hemoptysis and production of sputum, and the conventional chest x- ray...
  33. ACID AEROSOL--RESPIRATORY EFFECTS IN INFANTS AND MOTHERS
    Brian Leaderer; Fiscal Year: 1992
    ..or chronic upper and lower respiratory symptoms in infants age 3-15 months (a sensitive population), including cough, phlegm, wheeze, runny/stuffy nose, etc...
  34. Evaluation of Wire Electrodes to Activate the Expiratory Muscles to Restore Cough
    Anthony DiMarco; Fiscal Year: 2009
    ..account for significant morbidity and mortality in patients with spinal cord injury due to their inability to cough and clear secretions...
  35. Evaluation of Wire Electrodes to Activate the Expiratory Muscles to Restore Cough
    Anthony F DiMarco; Fiscal Year: 2010
    ..account for significant morbidity and mortality in patients with spinal cord injury due to their inability to cough and clear secretions...
  36. Throat Clearing, Coughing, and Alternative Behaviors
    HEATHER BONILHA; Fiscal Year: 2009
    ..abusive behaviors are commonly replaced with less abuse clearing maneuvers inclusive of: soft throat clear, silent cough, hard swallow, and hard swallow with a fluid bolus...
  37. Throat Clearing, Coughing, and Alternative Behaviors
    Heather Shaw Bonilha; Fiscal Year: 2010
    ..abusive behaviors are commonly replaced with less abuse clearing maneuvers inclusive of: soft throat clear, silent cough, hard swallow, and hard swallow with a fluid bolus...
  38. Development of anti-human TL1A monoclonal antibody for the treatment of human ast
    Vadim V Deyev; Fiscal Year: 2010
    ..debilitating disease characterized by intermittent attacks of wheezing, shortness of breath, chest tightness, cough and excess sputum/mucus production...
  39. Throat Clearing, Coughing, and Alternative Behaviors
    HEATHER BONILHA; Fiscal Year: 2009
    ..abusive behaviors are commonly replaced with less abuse clearing maneuvers inclusive of: soft throat clear, silent cough, hard swallow, and hard swallow with a fluid bolus...
  40. Bordetella pathogenesis: an undergraduate research tool
    Louise Temple; Fiscal Year: 2007
    ..avium, causes a highly contagious respiratory disease in its avian hosts that has striking similarity to whooping cough in children, caused by B. pertussis. We have the advantage of observing B...
  41. Bordetella pathogenesis: an undergraduate research tool
    Louise M Temple; Fiscal Year: 2010
    ..avium, causes a highly contagious respiratory disease in its avian hosts that has striking similarity to whooping cough in children, caused by B. pertussis. We have the advantage of observing B...
  42. Bordetella pathogenesis: an undergraduate research tool
    Louise Temple; Fiscal Year: 2009
    ..avium, causes a highly contagious respiratory disease in its avian hosts that has striking similarity to whooping cough in children, caused by B. pertussis. We have the advantage of observing B...
  43. Mechanisms of brevetoxin induced bronchial & nasal response in airways
    William Abraham; Fiscal Year: 2000
    ..red tide" toxins has been associated with both lower and upper airway symptoms in humans such as non-productive cough, shortness of breath, rhinorrhea, and sneezing, and it has been suggested that the toxin predisposes asthma ..
  44. Effect of Pertussis Toxin on Cough in Guinea Pig
    NICHOLAS CARBONETTI; Fiscal Year: 2004
    Bordetella pertussis is a gram-negative bacterial pathogen that causes the disease known as pertussis or whooping cough. After respiratory tract infection by the bacteria, the disease is characterized by a severe and prolonged cough, ..
  45. Effect of Pertussis Toxin on Cough in Guinea Pig
    NICHOLAS CARBONETTI; Fiscal Year: 2005
    Bordetella pertussis is a gram-negative bacterial pathogen that causes the disease known as pertussis or whooping cough. After respiratory tract infection by the bacteria, the disease is characterized by a severe and prolonged cough, ..
  46. Clinical Risk Factors for Barretts Esophagus in a Primary Care Setting
    Blair Jobe; Fiscal Year: 2009
    ..Dr. Jobe's group has systematically screened otolaryngology patients with cough and hoarseness for BE...
  47. Age-associated Toll-like receptor dysfunction in the lungs
    Carlos Orihuela; Fiscal Year: 2009
    ..in the elderly;2) why 10% of the elderly with pneumonia show no overt clinical signs of infection such as fever, cough, or dyspnea;and 3) why lack of fever is a prognostic indicator of poor clinical outcome...
  48. Neurotrophin Regulation of the Airway Parasympathetic Nervous System
    Allen Myers; Fiscal Year: 2009
    ..such as NGF, are increased in the inflamed or infected airways and many symptoms of these diseases (hyperactivity, cough, mucous production) may be related to altered or aberrant functions of the airway nervous system as seen in asthma,..
  49. ADHERENCE OF BORDETELLA PERTUSSIS TO HUMAN CELLS
    Elaine Tuomanen; Fiscal Year: 1993
    ..As many steps in the pathogenicity of whooping cough are still undefined, rational design of pertussis vaccine improvements is difficult...
  50. ASTHMA SEVERITY IN CHILDREN AND ENVIRONMENTAL AGENTS
    Brian Leaderer; Fiscal Year: 2002
    ..or chronic upper and lower respiratory symptoms in infants age 3-15 months (a sensitive population), including cough, phlegm, wheeze, runny/stuffy nose, etc...
  51. ADHERENCE OF BORDETELLA PERTUSSIS TO HUMAN CELLS
    Elaine Tuomanen; Fiscal Year: 1991
    ..As many steps in the pathogenicity of whooping cough are still undefined, rational design of pertussis vaccine improvements is difficult...
  52. ASTHMA SEVERITY IN CHILDREN AND ENVIRONMENTAL AGENTS
    Brian Leaderer; Fiscal Year: 2003
    ..or chronic upper and lower respiratory symptoms in infants age 3-15 months (a sensitive population), including cough, phlegm, wheeze, runny/stuffy nose, etc...
  53. ASTHMA SEVERITY IN CHILDREN AND ENVIRONMENTAL AGENTS
    Brian Leaderer; Fiscal Year: 2001
    ..or chronic upper and lower respiratory symptoms in infants age 3-15 months (a sensitive population), including cough, phlegm, wheeze, runny/stuffy nose, etc...
  54. ASTHMA SEVERITY IN CHILDREN AND ENVIRONMENTAL AGENTS
    Brian Leaderer; Fiscal Year: 2000
    ..or chronic upper and lower respiratory symptoms in infants age 3-15 months (a sensitive population), including cough, phlegm, wheeze, runny/stuffy nose, etc...
  55. ASTHMA SEVERITY IN CHILDREN AND ENVIRONMENTAL AGENTS
    Brian Leaderer; Fiscal Year: 1999
    ..or chronic upper and lower respiratory symptoms in infants age 3-15 months (a sensitive population), including cough, phlegm, wheeze, runny/stuffy nose, etc...
  56. Neurotrophin Regulation of the Airway Parasympathetic Nervous System
    Allen C Myers; Fiscal Year: 2010
    ..such as NGF, are increased in the inflamed or infected airways and many symptoms of these diseases (hyperactivity, cough, mucous production) may be related to altered or aberrant functions of the airway nervous system as seen in asthma,..
  57. Host-Pathogen Interactions in the Mammalian Airway
    Gill Diamond; Fiscal Year: 2004
    ..pertussis, the causative agent of whooping cough in humans...
  58. Host-Pathogen Interactions in the Mammalian Airway
    Gill Diamond; Fiscal Year: 2003
    ..pertussis, the causative agent of whooping cough in humans...
  59. Host-Pathogen Interactions in the Mammalian Airway
    Gill Diamond; Fiscal Year: 2005
    ..pertussis, the causative agent of whooping cough in humans...
  60. Host-Pathogen Interactions in the Mammalian Airway
    Gill Diamond; Fiscal Year: 2006
    ..pertussis, the causative agent of whooping cough in humans...
  61. ACID AEROSOL--RESPIRATORY EFFECTS IN INFANTS AND MOTHERS
    Brian Leaderer; Fiscal Year: 1990
    ..or chronic upper and lower respiratory symptoms in infants age 6-24 months (a sensitive population), including cough, phlegm, wheeze, runny/stuffy nose, etc...
  62. Photodynamic Therapy for the Treatment of Obstructive E*
    Todd Demmy; Fiscal Year: 2007
    ..Tumor response and symptom relief (cough, dyspnea, hemoptysis) will be determined at Day 5, one month and three months...
  63. Photodynamic Therapy for the Treatment of Obstructive E*
    Todd Demmy; Fiscal Year: 2006
    ..Tumor response and symptom relief (cough, dyspnea, hemoptysis) will be determined at Day 5, one month and three months...
  64. Nitric Oxide and Chronic Rhinosinusitis
    Abraham Jacob; Fiscal Year: 2001
    ..are believed to result in mucosal disruption and hypersecretion, nasal obstruction, postnasal discharge, cough, headache, and facial pressure...
  65. Reflux Disease in Patients with Throat Signs/Symptoms
    Michael Vaezi; Fiscal Year: 2004
    ..Laryngoscopic examination of patients with symptoms of hoarseness, sore throat, throat clearing and chronic cough commonly shows laryngeal abnormalities including laryngitis and vocal cord lesions including polyps, granuloma and ..
  66. Reflux Disease in Patients with Throat Signs/Symptoms
    Michael Vaezi; Fiscal Year: 2002
    ..Laryngoscopic examination of patients with symptoms of hoarseness, sore throat, throat clearing and chronic cough commonly shows laryngeal abnormalities including laryngitis and vocal cord lesions including polyps, granuloma and ..
  67. Reflux Disease in Patients with Throat Signs/Symptoms
    Michael Vaezi; Fiscal Year: 2005
    ..Laryngoscopic examination of patients with symptoms of hoarseness, sore throat, throat clearing and chronic cough commonly shows laryngeal abnormalities including laryngitis and vocal cord lesions including polyps, granuloma and ..
  68. Reflux Disease in Patients with Throat Signs/Symptoms
    Michael Vaezi; Fiscal Year: 2003
    ..Laryngoscopic examination of patients with symptoms of hoarseness, sore throat, throat clearing and chronic cough commonly shows laryngeal abnormalities including laryngitis and vocal cord lesions including polyps, granuloma and ..
  69. Strategies to Prevent COPD Exacerbation
    Fernando Martinez; Fiscal Year: 2005
    ..Acute exacerbations of chronic bronchitis (AECBs), defined as the acute worsening of breathlessness, cough, sputum volume or sputum purulence, are associated with marked acute deteriorations of symptoms, health related ..