sleep apnea syndromes

Summary

Summary: Disorders characterized by multiple cessations of respirations during sleep that induce partial arousals and interfere with the maintenance of sleep. Sleep apnea syndromes are divided into central (see SLEEP APNEA, CENTRAL), obstructive (see SLEEP APNEA, OBSTRUCTIVE), and mixed central-obstructive types.

Top Publications

  1. ncbi Prospective study of the association between sleep-disordered breathing and hypertension
    P E Peppard
    Department of Preventive Medicine, University of Wisconsin School of Medicine, Madison 53705, USA
    N Engl J Med 342:1378-84. 2000
  2. ncbi A new method for measuring daytime sleepiness: the Epworth sleepiness scale
    M W Johns
    Sleep Disorders Unit, Epworth Hospital, Melbourne, Victoria, Australia
    Sleep 14:540-5. 1991
  3. ncbi Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study
    E Shahar
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
    Am J Respir Crit Care Med 163:19-25. 2001
  4. ncbi Sleep-disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health Study
    Naresh M Punjabi
    Division of Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD21224, USA
    Am J Epidemiol 160:521-30. 2004
  5. ncbi Longitudinal study of moderate weight change and sleep-disordered breathing
    P E Peppard
    University of Wisconsin School of Medicine, Department of Preventive Medicine, 502 N Walnut St, Madison, WI 53705, USA
    JAMA 284:3015-21. 2000
  6. ncbi Practice parameters for the indications for polysomnography and related procedures: an update for 2005
    Clete A Kushida
    Stanford University Center of Excellence for Sleep Disorders, Stanford, CA, USA
    Sleep 28:499-521. 2005
  7. pmc Sleep-disordered breathing and mortality: a prospective cohort study
    Naresh M Punjabi
    Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Med 6:e1000132. 2009
  8. doi Sleep apnea and cardiovascular disease: an American Heart Association/american College Of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on
    Virend K Somers
    Circulation 118:1080-111. 2008
  9. ncbi Excess weight and sleep-disordered breathing
    Terry Young
    Department of Population Health Sciences, University of Wisconsin Madison, USA
    J Appl Physiol (1985) 99:1592-9. 2005
  10. pmc Obstructive sleep apnoea syndrome as a risk factor for hypertension: population study
    P Lavie
    Sleep Laboratory, Bruce Rappaport Faculty of Medicine, Israel Institute of Technology, Haifa, Israel
    BMJ 320:479-82. 2000

Research Grants

Detail Information

Publications237 found, 100 shown here

  1. ncbi Prospective study of the association between sleep-disordered breathing and hypertension
    P E Peppard
    Department of Preventive Medicine, University of Wisconsin School of Medicine, Madison 53705, USA
    N Engl J Med 342:1378-84. 2000
    ....
  2. ncbi A new method for measuring daytime sleepiness: the Epworth sleepiness scale
    M W Johns
    Sleep Disorders Unit, Epworth Hospital, Melbourne, Victoria, Australia
    Sleep 14:540-5. 1991
    ..ESS scores of patients who simply snored did not differ from controls...
  3. ncbi Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study
    E Shahar
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
    Am J Respir Crit Care Med 163:19-25. 2001
    ..99-1.62), respectively. These findings are compatible with modest to moderate effects of sleep-disordered breathing on heterogeneous manifestations of CVD within a range of AHI values that are considered normal or only mildly elevated...
  4. ncbi Sleep-disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health Study
    Naresh M Punjabi
    Division of Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD21224, USA
    Am J Epidemiol 160:521-30. 2004
    ..The results of this study suggest that SDB is independently associated with glucose intolerance and insulin resistance and may lead to type 2 diabetes mellitus...
  5. ncbi Longitudinal study of moderate weight change and sleep-disordered breathing
    P E Peppard
    University of Wisconsin School of Medicine, Department of Preventive Medicine, 502 N Walnut St, Madison, WI 53705, USA
    JAMA 284:3015-21. 2000
    ..Excess body weight is positively associated with sleep-disordered breathing (SDB), a prevalent condition in the US general population. No large study has been conducted of the longitudinal association between SDB and change in weight...
  6. ncbi Practice parameters for the indications for polysomnography and related procedures: an update for 2005
    Clete A Kushida
    Stanford University Center of Excellence for Sleep Disorders, Stanford, CA, USA
    Sleep 28:499-521. 2005
    ....
  7. pmc Sleep-disordered breathing and mortality: a prospective cohort study
    Naresh M Punjabi
    Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Med 6:e1000132. 2009
    ....
  8. doi Sleep apnea and cardiovascular disease: an American Heart Association/american College Of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on
    Virend K Somers
    Circulation 118:1080-111. 2008
  9. ncbi Excess weight and sleep-disordered breathing
    Terry Young
    Department of Population Health Sciences, University of Wisconsin Madison, USA
    J Appl Physiol (1985) 99:1592-9. 2005
    ..Clearly, if the expanding epidemic of obesity seen in the United States continues, the prevalence of SDB will almost certainly increase, along with the proportion of SDB attributable to obesity...
  10. pmc Obstructive sleep apnoea syndrome as a risk factor for hypertension: population study
    P Lavie
    Sleep Laboratory, Bruce Rappaport Faculty of Medicine, Israel Institute of Technology, Haifa, Israel
    BMJ 320:479-82. 2000
    ..To assess whether sleep apnoea syndrome is an independent risk factor for hypertension...
  11. pmc Sleep. 4: Sleepiness, cognitive function, and quality of life in obstructive sleep apnoea/hypopnoea syndrome
    H M Engleman
    Edinburgh Sleep Centre, Unit of Respiratory Medicine, University of Edinburgh, Lauriston Place, Edinburgh EH3 9YW, Scotland, UK
    Thorax 59:618-22. 2004
    ..The evidence is compatible with hypotheses that these deficits are reversible with treatment, particularly for patients with severe disease...
  12. pmc Alterations in Glucose Disposal in Sleep-disordered Breathing
    Naresh M Punjabi
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 179:235-40. 2009
    ..However, data on whether SDB alters in vivo kinetics of glucose and insulin are lacking...
  13. pmc Association of sleep-disordered breathing and the occurrence of stroke
    Michael Arzt
    Toronto General Hospital University Health Network, 9N 943, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada
    Am J Respir Crit Care Med 172:1447-51. 2005
    ..However, these studies either used surrogate markers of sleep-disordered breathing or could not, due to cross-sectional design, address the temporal relationship between sleep-disordered breathing and stroke...
  14. pmc Sleep-disordered breathing in community-dwelling elderly
    S Ancoli-Israel
    Department of Psychiatry, University of California, San Diego
    Sleep 14:486-95. 1991
    ..Despite statistical significance, all of the associations between interview variables and apnea indices were small. No combination of demographic variables and symptoms allowed highly reliable prediction of AI or RDI...
  15. ncbi The Sleep Heart Health Study: design, rationale, and methods
    S F Quan
    Department of Medicine and Respiratory Sciences Center, University of Arizona, Tucson 85724, USA
    Sleep 20:1077-85. 1997
    ..The study provides sufficient statistical power for assessing OSA and other SDB as risk factors for major cardiovascular events, including myocardial infarction and stroke...
  16. pmc A controlled study of sleep related disordered breathing in obese children
    Y K Wing
    Department of Psychiatry, Prince of Wales and Shatin Hospital, Shatin, The Chinese University of Hong Kong, Hong Kong SAR, China
    Arch Dis Child 88:1043-7. 2003
    ..Unlike the adult sleep related disordered breathing (SDB) patients who are typically obese, the relation between obesity and childhood SDB is not clear...
  17. pmc A mediation model linking body weight, cognition, and sleep-disordered breathing
    Karen Spruyt
    Department of Pediatrics, Pritzker School of Medicine, The University of Chicago, IL 60637, USA
    Am J Respir Crit Care Med 185:199-205. 2012
    ....
  18. doi Central cholinergic regulation of respiration: nicotinic receptors
    Xuesi M Shao
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
    Acta Pharmacol Sin 30:761-70. 2009
    ....
  19. ncbi Description and validation of the apnea risk evaluation system: a novel method to diagnose sleep apnea-hypopnea in the home
    Philip R Westbrook
    Advanced Brain Monitoring, Inc, 2850 Pio Pico Dr, Suite A, Carlsbad, CA 92008, USA
    Chest 128:2166-75. 2005
    ..To evaluate the accuracy and practicality of the Apnea Risk Evaluation System (ARES; Advanced Brain Monitoring; Carlsbad, CA), a limited-channel system for diagnosing sleep apnea/hypopnea in the home...
  20. ncbi Short-term variability of respiration and sleep during unattended nonlaboratory polysomnography--the Sleep Heart Health Study. [corrected]
    Stuart F Quan
    Arizona Respiratory Center and Department of Medicine, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Sleep 25:843-9. 2002
    ..To determine the short-term variability of indices of disturbed respiration and sleep during 2 nights of unattended nonlaboratory polysomnography conducted several months apart...
  21. pmc Prospective study of sleep-disordered breathing and hypertension: the Sleep Heart Health Study
    GEORGE T O'CONNOR
    Pulmonary Center, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
    Am J Respir Crit Care Med 179:1159-64. 2009
    ..Cross-sectional epidemiologic studies show an association between sleep-disordered breathing and hypertension, but only one cohort study has examined sleep-disordered breathing as a risk factor for incident hypertension...
  22. ncbi Marked decrease in sleepiness in patients with sleep apnea by etanercept, a tumor necrosis factor-alpha antagonist
    A N Vgontzas
    Department of Psychiatry H073, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 89:4409-13. 2004
    ..9 vs. 3.1 min), suggests that proinflammatory cytokines contribute to the pathogenesis of OSA/sleepiness...
  23. ncbi Diabetes and sleep disturbances: findings from the Sleep Heart Health Study
    Helaine E Resnick
    MedStar Research Institute, Hyattsville, Maryland 20783, USA
    Diabetes Care 26:702-9. 2003
    ..To test the hypothesis that diabetes is independently associated with sleep-disordered breathing (SDB), and in particular that diabetes is associated with sleep abnormalities of a central, rather than obstructive, nature...
  24. ncbi Sleep-disordered breathing occurs frequently in stable outpatients with congestive heart failure
    Katherine Ferrier
    WellSleep, Department of Medicine, Wellington School of Medicine and Health Sciences, New Zealand
    Chest 128:2116-22. 2005
    ..The prevalence, type, and severity of SDB in unselected stable outpatients with CHF are unknown...
  25. ncbi A survey screen for prediction of apnea
    G Maislin
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia 19104-4283, USA
    Sleep 18:158-66. 1995
    ..79 (p < 0.0001). For BMI alone, it was 0.73, and for an index measuring the self-report of the frequency of apnea symptoms, it was 0.70. The multivariable apnea risk index has potential utility in clinical settings...
  26. ncbi Measuring agreement between diagnostic devices
    W Ward Flemons
    Faculty of Medicine, University of Calgary, Calgary, AB, Canada
    Chest 124:1535-42. 2003
    ..Each approach has advantages and limitations, which are highlighted in this review...
  27. doi Current opinions and clinical practice in the titration of oral appliances in the treatment of sleep-disordered breathing
    Marijke Dieltjens
    Clinical Department of Special Care Dentistry, University of Antwerp UA and Antwerp University Hospital UZA, Edegem, Antwerp, Belgium
    Sleep Med Rev 16:177-85. 2012
    ..At present, a consensus exists that an optimal titration protocol is of primary importance to achieve a successful treatment outcome with an MRA. To date however, there is no consensus on how to define the optimal titration protocol...
  28. ncbi Effect of nasal continuous positive airway pressure during sleep on 24-hour blood pressure in obstructive sleep apnea
    I Wilcox
    Department of Medicine, University of Sydney, Australia
    Sleep 16:539-44. 1993
    ....
  29. ncbi Mortality in sleep apnea patients: a multivariate analysis of risk factors
    P Lavie
    Sleep Laboratory and Unit of Pulmonary Diseases, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa
    Sleep 18:149-57. 1995
    ..Age, BMI and hypertension predicted MI deaths in addition to lung disease. These results were interpreted to suggest that SAS affects death indirectly, most probably by being a risk factor for hypertension...
  30. ncbi Invited review: Physiological consequences of intermittent hypoxia: systemic blood pressure
    E C Fletcher
    Division of Respiratory, Critical Care and Environmental Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    J Appl Physiol (1985) 90:1600-5. 2001
    ..It appears that adrenergic and renin-angiotensin system overactivity contributes to the early chronic elevated blood pressure in rat intermittent hypoxia and perhaps to human hypertension associated with obstructive sleep apnea...
  31. ncbi Analysis of the interbeat interval increment to detect obstructive sleep apnoea/hypopnoea
    F Roche
    Department of Clinical Physiology and Exercise, Faculty of Medicine, Jacques Lisfranc University Jean Monnet, Saint Etienne, France, and Sleep Laboratory, Department of Psychiatry, University Hospital, Geneva, Switzerland
    Eur Respir J 29:1206-11. 2007
    ..Higher power spectral density of the interbeat interval increment of very low frequencies may also indicate disrupted sleep in the absence of clear clinical symptoms of sleep apnoea/hypopnoea syndrome...
  32. ncbi Outcome of COPD patients with mild daytime hypoxaemia with or without sleep-related oxygen desaturation
    A Chaouat
    Dept of Pneumology, University Hospital, Strasbourg, France
    Eur Respir J 17:848-55. 2001
    ..Such isolated nocturnal hypoxaemia or sleep-related worsening of moderate daytime hypoxaemia does not appear to favour the development of pulmonary hypertension, nor to lead to worsening of daytime blood gases...
  33. ncbi Continuous analysis and monitoring of snores and their relationship to the apnea-hypopnea index
    Jose Antonio Fiz
    Hospital de Navarra, Fundación Miguel Servet, Pamplona, Navarra, Spain
    Laryngoscope 120:854-62. 2010
    ....
  34. pmc Sleep disordered breathing with excessive daytime sleepiness is a risk factor for mortality in older adults
    Nalaka S Gooneratne
    Division of Geriatric Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Sleep 34:435-42. 2011
    ..This study examined the relationship between daytime sleepiness, SDB, self-report sleep parameters, and mortality in older adults...
  35. ncbi Home diagnosis of sleep apnea: a systematic review of the literature. An evidence review cosponsored by the American Academy of Sleep Medicine, the American College of Chest Physicians, and the American Thoracic Society
    W Ward Flemons
    Faculty of Medicine, University of Calgary, Calgary, AB, Canada
    Chest 124:1543-79. 2003
  36. doi Non-CPAP therapies in obstructive sleep apnoea: mandibular advancement device therapy
    Marie Marklund
    Dept of Orthodontics, Faculty of Medicine, Umea University, Umea, Sweden
    Eur Respir J 39:1241-7. 2012
    ..The treatment must be followed up and the device adjusted or exchanged in relation to the outcome...
  37. pmc Green tea catechin polyphenols attenuate behavioral and oxidative responses to intermittent hypoxia
    Isabel C Burckhardt
    Kosair Children s Hospital Research Institute, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
    Am J Respir Crit Care Med 177:1135-41. 2008
    ..We hypothesized that green tea catechin polyphenols (GTPs) may attenuate IH-induced neurobehavioral deficits by reducing IH-induced NADPH oxidase expression, lipid peroxidation, and inflammation...
  38. ncbi Systematic comparison of different algorithms for apnoea detection based on electrocardiogram recordings
    T Penzel
    Department of Respiratory Critical Care Medicine, Hospital of Philipps University, Marburg, Germany
    Med Biol Eng Comput 40:402-7. 2002
    ..Four of these algorithms achieved perfect scores of 100% in the first part of the study, and two achieved an accuracy of over 90% in the second part of the study...
  39. ncbi Nocturnal haemodialysis increases pharyngeal size in patients with sleep apnoea and end-stage renal disease
    Jaime M Beecroft
    Department of Medicine, University of Calgary, Alberta, Canada
    Nephrol Dial Transplant 23:673-9. 2008
    ..We hypothesized that NHD increases pharyngeal cross-sectional area and that this is associated with an improvement in sleep apnoea...
  40. ncbi Sleep-disordered breathing as a risk factor for cerebrovascular disease: a case-control study in patients with transient ischemic attacks
    Nigel McArdle
    Department of Medicine, University of Edinburgh, Royal Infirmary, Edinburgh, UK
    Stroke 34:2916-21. 2003
    ..We explored this relationship in transient ischemic attack (TIA) patients because they are less likely than stroke patients to have OSAH as a consequence of cerebrovascular disease...
  41. ncbi Positive effect of CPAP treatment on the control of difficult-to-treat hypertension
    M A Martínez-García
    Pneumology Unit, Requena General Hospital, Valencia, Spain
    Eur Respir J 29:951-7. 2007
    ..Continuous positive airway pressure treatment significantly reduces systolic blood pressure, particularly at night, and normalises the nocturnal pressure pattern in patients with difficult-to-control hypertension and sleep apnoea...
  42. ncbi Effect of nocturnal nasal continuous positive airway pressure on blood pressure in obstructive sleep apnea
    Lydia A Bazzano
    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA
    Hypertension 50:417-23. 2007
    ..38 to -0.05). Net reductions in blood pressure were not statistically different between daytime and nighttime. These results indicate that CPAP decreases blood pressure among those with OSA and may help prevent hypertension...
  43. ncbi Neurobehavioral morbidity associated with disordered breathing during sleep in children: a comprehensive review
    Dean W Beebe
    Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, OH 45229, USA
    Sleep 29:1115-34. 2006
    ..To comprehensively review research on the association between childhood sleep-disordered breathing (SDB) and neurobehavioral functioning...
  44. ncbi Endogenous excitatory drive modulating respiratory muscle activity across sleep-wake states
    Erin Chan
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 174:1264-73. 2006
    ..However, a neurotransmitter substrate mediating respiratory muscle activation across sleep-wake states has not been identified...
  45. ncbi Hypothalamic-pituitary-adrenal axis activation in obstructive sleep apnea: the effect of continuous positive airway pressure therapy
    David E Henley
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol BS1 3NY, United Kingdom
    J Clin Endocrinol Metab 94:4234-42. 2009
    ..We hypothesized that these may result from OSA-induced perturbations of endogenous ultradian hypothalamic-pituitary-adrenal axis activity...
  46. ncbi Sleep apnea in early and advanced chronic kidney disease: Kaiser Permanente Southern California cohort
    John J Sim
    Division of Nephrology and Hypertension, Kaiser Permanente Los Angeles Medical Center, 4700 Sunset Blvd, Los Angeles, CA 90027, USA
    Chest 135:710-6. 2009
    ..This study sought to determine whether an association exists between SA and early stages of chronic kidney disease (CKD) where SA may represent an important comorbidity and potential risk factor in kidney disease...
  47. pmc Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: implications for recurrent apneas
    Ying Jie Peng
    Department of Physiology and Biophysics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 100:10073-8. 2003
    ..The sensory LTF may contribute to persistent reflex activation of sympathetic nerve activity and blood pressure in recurrent apnea patients experiencing CIH...
  48. ncbi Incidence of sleep-disordered breathing in an urban adult population: the relative importance of risk factors in the development of sleep-disordered breathing
    Peter V Tishler
    Veterans Affairs Boston Healthcare System and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    JAMA 289:2230-7. 2003
    ..Sleep-disordered breathing (SDB) is both prevalent and associated with serious chronic illness. The incidence of SDB and the effect of risk factors on this incidence are unknown...
  49. ncbi Snoring in preschool children: prevalence, severity and risk factors
    C E Kuehni
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    Eur Respir J 31:326-33. 2008
    ..The strong association with atopic disorders, viral infections and environmental exposures suggests a complex aetiology, based on a general vulnerability of the respiratory tract...
  50. ncbi High prevalence of unrecognized sleep apnoea in drug-resistant hypertension
    A G Logan
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and University of Toronto, Toronto, Ontario, Canada
    J Hypertens 19:2271-7. 2001
    ..To determine the prevalence of obstructive sleep apnoea (OSA) in adult patients with drug-resistant hypertension, a common problem in a tertiary care facility...
  51. ncbi Sleep in overweight adolescents: shorter sleep, poorer sleep quality, sleepiness, and sleep-disordered breathing
    Dean W Beebe
    Division of Behavioral Medicine and Clinical Psychology MLC 3015, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    J Pediatr Psychol 32:69-79. 2007
    ..To document the sleep of overweight adolescents and to explore the degree to which weight-related sleep pathology might account for diminished psychosocial outcome...
  52. ncbi Heart failure and sleep apnoea: to sleep perchance to dream
    Susana Ferreira
    Faculdade Medicina do Porto, Portugal
    Eur J Heart Fail 8:227-36. 2006
    ....
  53. ncbi Variation in symptoms of sleep-disordered breathing with race and ethnicity: the Sleep Heart Health Study
    GEORGE T O'CONNOR
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118 2394, USA
    Sleep 26:74-9. 2003
    ..To examine the relation of sleep-related symptoms to race and ethnicity in a diverse sample of middle-aged and older men and women...
  54. ncbi Long-term nasal continuous positive airway pressure administration can normalize hypertension in obstructive sleep apnea patients
    M Suzuki
    Stanford University Sleep Disorders Clinic and Research Center, California 94304
    Sleep 16:545-9. 1993
    ..Average HR during the day and at night decreased significantly from 85.2 bpm to 72.6 bpm and from 69.8 bpm to 56.5 bpm in the hypertensives (p = 0.04), but not in normotensives.(ABSTRACT TRUNCATED AT 250 WORDS)..
  55. ncbi The prevalence of sleepiness and the risk of sleep-disordered breathing in children with positive allergy test
    Stacey L Ishman
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Int Forum Allergy Rhinol 2:139-43. 2012
    ..We evaluated the prevalence of sleep-disordered breathing (SDB) and sleepiness in children with allergy and compared sleep-specific quality of life measures to those of children without allergy...
  56. doi Titrated mandibular advancement versus positive airway pressure for sleep apnoea
    F Gagnadoux
    Departement de Pneumologie, CHU, Angers, France
    Eur Respir J 34:914-20. 2009
    ..Both treatments improved functional outcomes to a similar degree. One-night titration of MAd had a low negative predictive value for treatment success...
  57. pmc Reactive oxygen species and the brain in sleep apnea
    Yang Wang
    Section of Pediatric Sleep Medicine, Department of Pediatrics, Comer Children s Hospital, The University of Chicago, Chicago, IL 60637, USA
    Respir Physiol Neurobiol 174:307-16. 2010
    ..The initial evidence for NADPH oxidase and mitochondrial involvement in IH-induced ROS production and neuronal injury unquestionably warrants future research efforts...
  58. ncbi Familial risk of sleep-disordered breathing
    Karin Lundkvist
    Department of Otorhinolaryngology, Karolinska Institutet, Stockholm, Sweden
    Sleep Med 13:668-73. 2012
    ....
  59. doi Cross-correlation of EEG frequency bands and heart rate variability for sleep apnoea classification
    Haslaile Abdullah
    School of Electrical and Computer Engineering, Science, Engineering and Health, RMIT University, 376 392 Swanston Street, GPO Box 2476V, Melbourne, Vic, 3001, Australia
    Med Biol Eng Comput 48:1261-9. 2010
    ..When delta and acceleration coefficients of the EEG features were incorporated, then the overall accuracy improved to 71%...
  60. ncbi Reliability and validity studies of the Turkish version of the Epworth Sleepiness Scale
    Bilgay Izci
    Department of Sleep Medicine, University of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, Scotland, UK
    Sleep Breath 12:161-8. 2008
    ..The ESStr is a reliable and valid measure of daytime sleepiness. These features and the simplicity of the ESStr make it a valuable measure for clinical management and research...
  61. doi Automatic breath-to-breath analysis of nocturnal polysomnographic recordings
    P J van Houdt
    Department of Research and Development, Kempenhaeghe, Postbus 61, 5590 AB, Heeze, The Netherlands
    Med Biol Eng Comput 49:819-30. 2011
    ....
  62. doi New tracheal sound feature for apnoea analysis
    A Kulkas
    Department of Clinical Neurophysiology, Medical Imaging Center, Pirkanmaa Hospital District, Tampere, Finland
    Med Biol Eng Comput 47:405-12. 2009
    ..8%. Due to the individual differences in tracheal sound signal amplitudes, developing amplitude-independent means for screening apnoea events is beneficial...
  63. doi Is obstructive sleep apnea a problem in Parkinson's disease?
    Valerie Cochen De Cock
    Sleep Disorders Unit, Pitie Salpetriere Hospital, APHP, Paris, France
    Sleep Med 11:247-52. 2010
    ..Upper airway dysfunction in PD may promote obstructive sleep apnea. However, the frequency and clinical relevance of sleep-disordered breathing in PD remains unclear...
  64. ncbi Platelet-activating factor receptor-deficient mice are protected from experimental sleep apnea-induced learning deficits
    Barry W Row
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
    J Neurochem 89:189-96. 2004
    ..Collectively, these findings indicate that inflammatory signaling and neurobehavioral impairments induced by IH are mediated through PAF receptors...
  65. pmc Impaired spatial working memory and altered choline acetyltransferase (CHAT) immunoreactivity and nicotinic receptor binding in rats exposed to intermittent hypoxia during sleep
    Barry W Row
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Behav Brain Res 177:308-14. 2007
    ..However, compensatory mechanisms may also be activated in other brain regions, and may provide potential therapeutic targets for the cognitive impairments associated with SDB...
  66. ncbi Neurobehavioral manifestations in obstructive sleep apnea syndrome before and after treatment with continuous positive airway pressure
    J Montplaisir
    , , , Canada
    Sleep 15:S17-9. 1992
    ..After treatment, hypoxemia-related deficits and some degree of sleepiness persist. These results raise the possibility of an irreversible anoxic central nervous system (CNS) damage in severe OSAS...
  67. doi Children's sleep and adjustment over time: the role of socioeconomic context
    Mona El-Sheikh
    Human Development and Family Studies, 203Spidle Hall, Auburn University, Auburn, AL 36849 5214, USA
    Child Dev 81:870-83. 2010
    ..Findings highlight the importance of adequate sleep for children's optimal development, especially in the context of ecological risk...
  68. ncbi Obesity, and not obstructive sleep apnea, is responsible for metabolic abnormalities in a cohort with sleep-disordered breathing
    S K Sharma
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, All India Institute of Medical Sciences, New Delhi 110029, India
    Sleep Med 8:12-7. 2007
    ..To assess the profile of metabolic abnormalities in subjects with obstructive sleep apnea (OSA)...
  69. ncbi High fat/refined carbohydrate diet enhances the susceptibility to spatial learning deficits in rats exposed to intermittent hypoxia
    A D Goldbart
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Brain Res 1090:190-6. 2006
    ..high fat refined carbohydrate diet (HF/RC) can induce similar deficits and associated changes in signaling pathways under normoxic conditions...
  70. ncbi The effect of chronic or intermittent hypoxia on cognition in childhood: a review of the evidence
    Joel L Bass
    Department of Pediatrics, Newton Wellesley Hospital, MassGeneral Hospital for Children, Harvard Medical School, Newton, Massachusetts 02462, USA
    Pediatrics 114:805-16. 2004
    ....
  71. ncbi Electroencephalographic changes during respiratory cycles predict sleepiness in sleep apnea
    Ronald D Chervin
    Michael S Aldrich Sleep Disorders Laboratory, University Hospital, 8D8702, P O Box 0117, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0117, USA
    Am J Respir Crit Care Med 171:652-8. 2005
    ..Quantification of these changes, which may reflect numerous inspiratory microarousals, could prove useful in prediction of excessive daytime sleepiness...
  72. ncbi All-cause mortality in males with sleep apnoea syndrome: declining mortality rates with age
    P Lavie
    Lloyd Rigler Sleep Apnoea Research Laboratory, B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Eur Respir J 25:514-20. 2005
    ..The lack of information about possible confounders and treatment effects should be taken into consideration in the interpretation of these results...
  73. ncbi Increased oxidative stress is associated with chronic intermittent hypoxia-mediated brain cortical neuronal cell apoptosis in a mouse model of sleep apnea
    W Xu
    Kosair Children s Hospital Research Institute, Department of Pediatrics, 215 Baxter Building I, 570 South Preston Street, University of Louisville, Louisville, KY 40202, USA
    Neuroscience 126:313-23. 2004
    ..Taken together, these findings suggest that the increased ROS production and oxidative stress propagation contribute, at least partially, to CIH-mediated cortical neuronal apoptosis and neurocognitive dysfunction...
  74. ncbi Physical examination: Mallampati score as an independent predictor of obstructive sleep apnea
    Thomas J Nuckton
    The California Pacific Medical Center Research Institute, San Francisco 94115 1821, USA
    Sleep 29:903-8. 2006
    ..Mallampati scoring of the orophyarynx is a simple noninvasive method used to assess the difficulty of endotracheal intubation, but its clinical usefulness has not been validated in patients with sleep-disordered breathing...
  75. pmc Association of alcohol consumption and sleep disordered breathing in men and women
    Paul E Peppard
    Department of Population Health Sciences, University of Wisconsin, Madison, WI, USA
    J Clin Sleep Med 3:265-70. 2007
    ..In this population-based epidemiology study, our objective is to measure the association of SDB with usual alcohol consumption habits...
  76. ncbi Impact of adenotonsillectomy on behavior in children with sleep-disordered breathing
    Hsueh Yu Li
    Department of Otolaryngology, Chang Gung Memorial Hospital, and Department of Nursing, Chang Gung Institute of Technology, Taoyuan, Taipei, Taiwan
    Laryngoscope 116:1142-7. 2006
    ..The aim of this study was to measure the impact of adenotonsillectomy on sleep-related adverse events and behavioral problems in children with sleep-disordered breathing...
  77. doi Behavior, cognition, and quality of life after adenotonsillectomy for pediatric sleep-disordered breathing: summary of the literature
    Susan L Garetz
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Otolaryngol Head Neck Surg 138:S19-26. 2008
    ....
  78. ncbi Does beta-blocker treatment influence central sleep apnoea?
    Thomas Köhnlein
    Department of Respiratory Medicine, Medizinische Hochschule Hannover Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Respir Med 101:850-3. 2007
    ..8+/-14.2 versus 7.4+/-8.5 (p<0.05) and 8.7+/-8.1 (p<0.05) in patients treated with metoprolol or carvedilol, respectively. The arousal index, sleep quality, and daytime sleepiness were improved in similar magnitude...
  79. ncbi Insights from studying human sleep disorders
    Mark W Mahowald
    Minnesota Regional Sleep Disorders Center, and Department of Neurology, Hennepin County Medical Center, and University of MN Medical School, Minneapolis, Minnesota 55415, USA
    Nature 437:1279-85. 2005
    ..Furthermore, contrary to common assumptions, wakefulness, rapid eye movement (REM) and non-REM sleep are not mutually exclusive states. This striking realization explains a fascinating range of clinical phenomena...
  80. ncbi Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia
    A N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University, Hershey 17033, USA
    J Clin Endocrinol Metab 85:1151-8. 2000
    ..We conclude that there is a strong independent association among sleep apnea, visceral obesity, insulin resistance and hypercytokinemia, which may contribute to the pathological manifestations and somatic sequelae of this condition...
  81. ncbi The effect of an increased intake of vegetables and fruit on weight loss, blood pressure and antioxidant defense in subjects with sleep related breathing disorders
    M Svendsen
    Department of Preventive Cardiology, Ulleval University Hospital, Oslo, Norway
    Eur J Clin Nutr 61:1301-11. 2007
    ..To assess the effect of an increased consumption of vegetables and fruit on body weight, risk factors for cardiovascular disease (CVD) and antioxidant defense in obese patients with sleep-related breathing disorders (SRBD)...
  82. ncbi Disorders of glucose metabolism in sleep apnea
    Naresh M Punjabi
    Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Appl Physiol (1985) 99:1998-2007. 2005
    ....
  83. ncbi Sleep apnoea in heart failure
    R Schulz
    University of Giessen Lung Center, Klinikstr 36, 35392 Giessen, and Charité University Hospital Berlin, Sleep Disorders Centre, Department of Cardiology Pulmonary Medicine, Germany
    Eur Respir J 29:1201-5. 2007
    ..This diagnostic approach should probably be adopted for all of these patients irrespective of the presence of sleep-related symptoms...
  84. ncbi [Prevalence of symptoms of sleep apnea syndrome. Study of a French middle-aged population]
    N Meslier
    Departement de Pneumologie, CHU Angers, France
    Rev Mal Respir 24:305-13. 2007
    ..To study the prevalence of symptoms of sleep apnoea syndrome (SAS) in a large French middle-aged population and to establish what proportion have symptoms that justify further investigation with a sleep study...
  85. ncbi Sleep apnea is induced by a high-fat diet and reversed and prevented by metformin in non-obese rats
    Wiam Ramadan
    EA 3901, Dysrégulations Métaboliques Acquises et Génétiques, Universite de Picardie Jules Verne, Faculte de Medecine, 3 rue des Louvels, F 80036 Amiens Cedex 1, France
    Obesity (Silver Spring) 15:1409-18. 2007
    ..We also studied whether metformin (an anti-hyperglycemic drug frequently used to treat insulin resistance) could reverse sleep apnea or prevent its occurrence in this experimental paradigm...
  86. ncbi Cognition, sleep and respiration in at-risk children treated for obstructive sleep apnoea
    H E Montgomery-Downs
    Division of Pediatric Sleep Medicine, Dept of Pediatrics, University of Louisville, Louisville, KY, USA
    Eur Respir J 25:336-42. 2005
    ....
  87. ncbi Predicting sleep apnea and excessive day sleepiness in the severely obese: indicators for polysomnography
    John B Dixon
    Monash University Department of Surgery, Alfred Hospital, Melbourne, Australia
    Chest 123:1134-41. 2003
    ..Selection of patients for OPS would be enhanced if we could better predict those likely to have clinically significant OSA...
  88. ncbi Traffic accidents in commercial long-haul truck drivers: the influence of sleep-disordered breathing and obesity
    R A Stoohs
    Stanford University Medical School, Sleep Disorders and Research Center, California
    Sleep 17:619-23. 1994
    ..Sleep-disordered breathing with hypoxemia and obesity are risk factors for automotive accidents...
  89. ncbi The association of sleep-disordered breathing and sleep symptoms with quality of life in the Sleep Heart Health Study
    C M Baldwin
    Department of Medicine, University of Arizona, Tucson 85724 5030, USA
    Sleep 24:96-105. 2001
    ..S. general population...
  90. ncbi Sleep-disordered breathing, glucose intolerance, and insulin resistance
    Naresh M Punjabi
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Respir Physiol Neurobiol 136:167-78. 2003
    ..Potential mediators of this association include altered adrenergic function, the direct effects of hypoxemia on glucose regulation, and release of proinflammatory cytokines that affect metabolism...
  91. ncbi Intermittent hypoxia is associated with oxidative stress and spatial learning deficits in the rat
    Barry W Row
    Kosair Children s Hospital Research Institute, University of Louisville, Baxter Biomedical Research Building, Suite 321, 570 South Preston Street, Louisville, KY 40202, USA
    Am J Respir Crit Care Med 167:1548-53. 2003
    ..Collectively, these findings indicate that the IH exposure is associated with increased oxidative stress, which is likely to play an important role in the behavioral impairments observed in a rodent model of sleep-disordered breathing...
  92. ncbi Prognostic value of nocturnal Cheyne-Stokes respiration in chronic heart failure
    P A Lanfranchi
    Division of Cardiology, Department of Bioengineering, Salvatore Maugeri Foundation, IRCCS, Veruno, Italy
    Circulation 99:1435-40. 1999
    ..The aim of the present study was to evaluate whether CSR could affect prognosis in patients with CHF...
  93. ncbi General physicians' perspective of sleep apnea from a developing country
    Syed Fayyaz Hussain
    Section of Pulmonary Medicine, The Aga Khan University, Hospital, Karachi, Pakistan
    Southeast Asian J Trop Med Public Health 34:420-3. 2003
    ..Half of the responders were aware of CPAP therapy for OSA, whereas 18% would have prescribed sedatives to treat sleep disturbances in OSA...
  94. ncbi Symptoms related to sleep-disordered breathing in white and Hispanic children: the Tucson Children's Assessment of Sleep Apnea Study
    James L Goodwin
    Arizona Respiratory Center, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Chest 124:196-203. 2003
    ..This article describes the parental report of sleep symptoms associated with SDB in Hispanic and white children...
  95. ncbi Sleep-disordered breathing and coronary artery disease: long-term prognosis
    T Mooe
    Department of Cardiology, Umea University Hospital, Umea, Sweden
    Am J Respir Crit Care Med 164:1910-3. 2001
    ..43-6.20, p = 0.004, respectively). We conclude that sleep-disordered breathing in patients with coronary artery disease is associated with a worse long-term prognosis and has an independent association with cerebrovascular events...
  96. ncbi Metabolic disturbances in obesity versus sleep apnoea: the importance of visceral obesity and insulin resistance
    A N Vgontzas
    Department of Psychiatry, Penn State College of Medicine, Hershey, PA 17033, USA
    J Intern Med 254:32-44. 2003
    ....
  97. pmc Central sleep apnoea syndrome in patients with chronic heart disease: a critical review of the current literature
    T Köhnlein
    Otto von Guericke Universitat Magdeburg, Department for Pulmonary and Intensive Care Medicine, Germany
    Thorax 57:547-54. 2002
    ..Adequately powered trials are needed with survival and health status as end points to establish whether correction of sleep related breathing abnormalities improves the outcome in patients with CHF...
  98. pmc Prevalence of sleep-disordered breathing in ages 40-64 years: a population-based survey
    D F Kripke
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093-0667, USA
    Sleep 20:65-76. 1997
    ..This survey indicates that sleep-disordered breathing is more common, especially among minorities, than had been previously believed, but less co-morbidity may be associated...
  99. pmc Case-control study of 24 hour ambulatory blood pressure in patients with obstructive sleep apnoea and normal matched control subjects
    C W Davies
    Department of Respiratory Medicine, Battle Hospital, Royal Berkshire and Battle NHS Trust, Reading RG3 1AG, UK
    Thorax 55:736-40. 2000
    ..A case-control study of 24 hour ambulatory blood pressure was undertaken in patients with OSA and matched controls to assess whether OSA is an independent correlate of diurnal hypertension...
  100. ncbi Neural structures that mediate sympathoexcitation during hypoxia
    P G Guyenet
    Department of Pharmacology, University of Virginia Health System, 1300 Jefferson Park Avenue, PO Box 800735, Charlottesville, VA 22908, USA
    Respir Physiol 121:147-62. 2000
    ..The literature is also examined in the context of cerebral ischemia, the Cushing response and the genesis of certain forms of hypertension...
  101. ncbi Dysfunctional mechanical coupling of upper airway tissues in sleep apnea syndrome
    F Series
    Unite de Recherche, Centre de Pneumologie de l Hôpital Laval, Quebec, Canada
    Am J Respir Crit Care Med 159:1551-5. 1999
    ..55, p = 0.007). We conclude that there is a significant difference between the uvular tissue elastance of SAHS and snorers, and that this difference influences the mechanical efficiency of MU contraction...

Research Grants122 found, 100 shown here

  1. Stimulation Induced Modulation of Sleep
    MATTHEW TARLER; Fiscal Year: 2009
    ..chemoreflexes can contribute to the severity of sleep apnea, and the development of hypertension in sleep apnea syndromes. In congestive heart failure, augmented carotid chemoreflexes contributes to the increased sympathetic ..
  2. CHOLINERGIC MECHANISMS OF BREATHING DURING SLEEP
    Ralph Lydic; Fiscal Year: 1990
    The sleep apnea syndromes have been estimated to affect 1 to 5% of the older adult male population, while the sudden infant death syndrome (SIDS) is the leading cause of death in infants between 1 month and 1 year of age...
  3. RESPIRATORY MUSCLES AND VENTILATORY CONTROL IN MAN
    John Sharp; Fiscal Year: 1980
    ..and responses to hypercapnia will be assessed in normals, respiratory disease patients and patients with sleep apnea syndromes while awake and in both quiet and R.E.M. sleep...
  4. CHOLINERGIC MECHANISMS OF BREATHING DURING SLEEP
    Ralph Lydic; Fiscal Year: 1992
    Breathing is significantly altered during the loss of wakefulness. The sleep apnea syndromes are currently estimated to affect 1 to 5% of the adult male population. About 7,000 children in the U.S...
  5. Genetic Mechanisms for Central Apneas
    Kingman Strohl; Fiscal Year: 2006
    ..A genomic approach to recurrent central apneas might provide pathogenic insight relevant to primary sleep apnea syndromes and neurological conditions associated with recurrent apneas and unstable breathing...
  6. Genetic Mechanisms for Central Apneas
    Kingman Strohl; Fiscal Year: 2007
    ..A genomic approach to recurrent central apneas might provide pathogenic insight relevant to primary sleep apnea syndromes and neurological conditions associated with recurrent apneas and unstable breathing...
  7. Mechanisms of Altered Glucose Metabolism in Sleep-Disordered Breathing
    Naresh Punjabi; Fiscal Year: 2010
    ..We will also investigate whether treatment of sleep disordered breathing with continuous positive airway pressure improves metabolic function. ..
  8. Sleep Apnea and Longitudinal Changes in Glycemia and Inflammation in Older Men
    Naresh Punjabi; Fiscal Year: 2008
    ....
  9. The Effects of Sleep Apnea on Metabolic Function
    Naresh Punjabi; Fiscal Year: 2004
    ..abstract_text> ..
  10. Effects of aging on sleep architecture
    Naresh Punjabi; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  11. Sleep Apnea and Longitudinal Changes in Glycemia and Inflammation in Older Men
    Naresh Punjabi; Fiscal Year: 2010
    ....
  12. EARLY IDENTIFICATION AND TREATMENT OF SLEEP APNEA
    Naresh Punjabi; Fiscal Year: 2003
    ..Punjabi the opportunity to reach his full potential as a clinical investigator. ..
  13. The Effects of Sleep Apnea on Metabolic Function
    Naresh Punjabi; Fiscal Year: 2006
    ..abstract_text> ..
  14. Longtitudinal Changes in Sleep Structure: Implications for Health Outcomes
    Naresh Punjabi; Fiscal Year: 2008
    ....
  15. Sleep Apnea and Longitudinal Changes in Glycemia and Inflammation in Older Men
    Naresh Punjabi; Fiscal Year: 2009
    ....
  16. The Effects of Sleep Apnea on Metabolic Function
    Naresh Punjabi; Fiscal Year: 2005
    ..abstract_text> ..
  17. Longtitudinal Changes in Sleep Structure: Implications for Health Outcomes
    Naresh Punjabi; Fiscal Year: 2007
    ....
  18. THE SLEEP HEART HEALTH STUDY
    Naresh Punjabi; Fiscal Year: 2007
    ..Accomplishing these goals will provide important information concerning the public health impact of SDB. ..
  19. Longtitudinal Changes in Sleep Structure: Implications for Health Outcomes
    Naresh Punjabi; Fiscal Year: 2009
    ....
  20. Longtitudinal Changes in Sleep Structure: Implications for Health Outcomes
    Naresh Punjabi; Fiscal Year: 2010
    ....
  21. Effects of Sleep Apnea on Metabolic Function
    Naresh Punjabi; Fiscal Year: 2003
    ..abstract_text> ..
  22. WORKING MEMORY IN OBSTRUCTIVE SLEEP APNEA-AN fMRI STUDY
    Robert Thomas; Fiscal Year: 2006
    ..abstract_text> ..
  23. ECG-derived estimators of sleep physiology
    Robert Thomas; Fiscal Year: 2006
    ..3) To correlate the biomarker with excessive daytime sleepiness, subjective sleep quality and cardiovascular morbidity (SHHS), and reduced neurocognitive function (NAPS). ..
  24. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David Carley; Fiscal Year: 2007
    ..Extending the progress of the first funding cycle, these aims will provide important insights regarding the state-dependent mechanisms by which the PPT modulates respiratory pattern. [unreadable] [unreadable]..
  25. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David Carley; Fiscal Year: 2008
    ..Extending the progress of the first funding cycle, these aims will provide important insights regarding the state-dependent mechanisms by which the PPT modulates respiratory pattern. ..
  26. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David Carley; Fiscal Year: 2009
    ..Extending the progress of the first funding cycle, these aims will provide important insights regarding the state-dependent mechanisms by which the PPT modulates respiratory pattern. ..
  27. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David Carley; Fiscal Year: 2006
    ..Extending the progress of the first funding cycle, these aims will provide important insights regarding the state-dependent mechanisms by which the PPT modulates respiratory pattern. [unreadable] [unreadable]..
  28. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David Carley; Fiscal Year: 2009
    ..Extending the progress of the first funding cycle, these aims will provide important insights regarding the state-dependent mechanisms by which the PPT modulates respiratory pattern. ..
  29. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David Carley; Fiscal Year: 2002
    ..These manipulations in old and young patients, controls, and rats will provide a comprehensive approach to define the mechanisms and importance of brainstem phasic event-induced respiratory instability in aging. ..
  30. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David W Carley; Fiscal Year: 2010
    ..Extending the progress of the first funding cycle, these aims will provide important insights regarding the state-dependent mechanisms by which the PPT modulates respiratory pattern. ..
  31. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David Carley; Fiscal Year: 2000
    ..These manipulations in old and young patients, controls, and rats will provide a comprehensive approach to define the mechanisms and importance of brainstem phasic event-induced respiratory instability in aging. ..
  32. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David Carley; Fiscal Year: 2003
    ..These manipulations in old and young patients, controls, and rats will provide a comprehensive approach to define the mechanisms and importance of brainstem phasic event-induced respiratory instability in aging. ..
  33. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David Carley; Fiscal Year: 2001
    ..These manipulations in old and young patients, controls, and rats will provide a comprehensive approach to define the mechanisms and importance of brainstem phasic event-induced respiratory instability in aging. ..
  34. THE ROLE OF CYTOKINES IN SLEEPINESS AND SLEEP APNEA
    Alexandros Vgontzas; Fiscal Year: 2002
    ..These studies collectively will provide additional evidence for a role of TNFalpha and IL-6 in EDS and lay the foundation for the development of potential therapeutic interventions. ..
  35. THE ROLE OF CYTOKINES IN SLEEPINESS AND SLEEP APNEA
    Alexandros Vgontzas; Fiscal Year: 2005
    ..These studies collectively will provide additional evidence for a role of TNFa and IL-6 in EDS and OSA and lay the foundation for the development of novel therapeutic interventions. ..
  36. THE ROLE OF CYTOKINES IN SLEEPINESS AND SLEEP APNEA
    Alexandros Vgontzas; Fiscal Year: 2009
    ..These studies collectively will provide additional evidence for a role of TNFa and IL-6 in EDS and OSA and lay the foundation for the development of novel therapeutic interventions. ..
  37. THE ROLE OF CYTOKINES IN SLEEPINESS AND SLEEP APNEA
    Alexandros Vgontzas; Fiscal Year: 2007
    ..These studies collectively will provide additional evidence for a role of TNFa and IL-6 in EDS and OSA and lay the foundation for the development of novel therapeutic interventions. ..
  38. THE ROLE OF CYTOKINES IN SLEEPINESS AND SLEEP APNEA
    Alexandros Vgontzas; Fiscal Year: 2006
    ..These studies collectively will provide additional evidence for a role of TNFa and IL-6 in EDS and OSA and lay the foundation for the development of novel therapeutic interventions. ..
  39. THE ROLE OF CYTOKINES IN SLEEPINESS AND SLEEP APNEA
    Alexandros Vgontzas; Fiscal Year: 2001
    ..These studies collectively will provide additional evidence for a role of TNFalpha and IL-6 in EDS and lay the foundation for the development of potential therapeutic interventions. ..
  40. THE ROLE OF CYTOKINES IN SLEEPINESS AND SLEEP APNEA
    Alexandros Vgontzas; Fiscal Year: 2003
    ..These studies collectively will provide additional evidence for a role of TNFalpha and IL-6 in EDS and lay the foundation for the development of potential therapeutic interventions. ..
  41. THE ROLE OF CYTOKINES IN SLEEPINESS AND SLEEP APNEA
    Alexandros Vgontzas; Fiscal Year: 2008
    ..These studies collectively will provide additional evidence for a role of TNFa and IL-6 in EDS and OSA and lay the foundation for the development of novel therapeutic interventions. ..
  42. Treatment of Obstructive Sleep Apnea After Stroke
    Devin Brown; Fiscal Year: 2007
    ..The University of Michigan, with a strong Stroke Program, Sleep Disorders Center, and School of Public Health will create the perfect environment for this candidate's career development. [unreadable] [unreadable]..
  43. Treatment of Obstructive Sleep Apnea After Stroke
    Devin Brown; Fiscal Year: 2008
    ..The University of Michigan, with a strong Stroke Program, Sleep Disorders Center, and School of Public Health will create the perfect environment for this candidate's career development. ..
  44. Postpartum Sleep Deprivation and Fragmentation: Effects on Maternal Functioning
    HAWLEY MONTGOMERY DOWNS; Fiscal Year: 2007
    ..The study results will help researchers develop better strategies for improving the sleep of new mothers, and in turn improving their ability to function effectively. [unreadable] [unreadable] [unreadable]..
  45. Sleep/Wake Contiuum in Lewy Body Disease
    Donald Bliwise; Fiscal Year: 2009
    ..The proposed work will also provide important clinical insights into disease correlates and disease course across the broad spectrum of Parkinsonism. ..
  46. Polysomnographic Assessment of Alternative Treatment
    Donald Bliwise; Fiscal Year: 2006
    ..abstract_text> ..
  47. Postpartum Sleep Deprivation and Fragmentation: Effects on Maternal Functioning
    HAWLEY MONTGOMERY DOWNS; Fiscal Year: 2008
    ..The study results will help researchers develop better strategies for improving the sleep of new mothers, and in turn improving their ability to function effectively. [unreadable] [unreadable] [unreadable]..
  48. Sleep/Wake Contiuum in Lewy Body Disease
    Donald Bliwise; Fiscal Year: 2007
    ..The proposed work will also provide important clinical insights into disease correlates and disease course across the broad spectrum of Parkinsonism. ..
  49. Sleep/Wake Contiuum in Lewy Body Disease
    Donald Bliwise; Fiscal Year: 2008
    ..The proposed work will also provide important clinical insights into disease correlates and disease course across the broad spectrum of Parkinsonism. ..
  50. SUNDOWN SYNDROME IN A SKILLED NURSING FACILITY
    Donald Bliwise; Fiscal Year: 2002
    ..These results will provide information on the mechanistic basis for sundowning in aged patients with dementing disorders. ..
  51. Biomarkers of Aging in the Bay Area Sleep Cohort
    Donald Bliwise; Fiscal Year: 2003
    ..abstract_text> ..
  52. Polysomnographic Assessment of Alternative Treatment
    Donald Bliwise; Fiscal Year: 2004
    ..abstract_text> ..
  53. Biomarkers of Aging in the Bay Area Sleep Cohort
    Donald Bliwise; Fiscal Year: 2004
    ..abstract_text> ..
  54. Polysomnographic Assessment of Alternative Treatment
    Donald Bliwise; Fiscal Year: 2002
    ..abstract_text> ..
  55. Snoring, Early Behavior, and Oxidant Stress
    HAWLEY MONTGOMERY DOWNS; Fiscal Year: 2004
    ..In addition, it may provide insights into a potential mechanism for this morbidity. ..
  56. Sleep/Wake Contiuum in Lewy Body Disease
    Donald Bliwise; Fiscal Year: 2008
    ..The proposed work will also provide important clinical insights into disease correlates and disease course across the broad spectrum of Parkinsonism. ..
  57. Polysomnographic Assessment of Alternative Treatment
    Donald Bliwise; Fiscal Year: 2001
    ..abstract_text> ..
  58. Polysomnographic Assessment of Alternative Treatment
    Donald Bliwise; Fiscal Year: 2000
    ..abstract_text> ..
  59. Biomarkers of Aging in the Bay Area Sleep Cohort
    Donald Bliwise; Fiscal Year: 2005
    ..abstract_text> ..
  60. Sleep/Wake Contiuum in Lewy Body Disease
    Donald Bliwise; Fiscal Year: 2006
    ..The proposed work will also provide important clinical insights into disease correlates and disease course across the broad spectrum of Parkinsonism. ..
  61. Sleep/Wake Contiuum in Lewy Body Disease
    Donald L Bliwise; Fiscal Year: 2010
    ..The proposed work will also provide important clinical insights into disease correlates and disease course across the broad spectrum of Parkinsonism. ..
  62. The REST Study: A Longitudinal, Bidirectional Examination of Retirement And Sleep
    Paul E Peppard; Fiscal Year: 2010
    ..They will also inform clinical decision making regarding treatment and behavioral recommendations for patients with sleep disorders before and after retirement. ..
  63. Polysomnographic Assessment of Alternative Treatment
    Donald Bliwise; Fiscal Year: 2003
    ..abstract_text> ..
  64. Cognitive Behavioral Therapy for Insomnia in Stable Heart Failure
    Nancy S Redeker; Fiscal Year: 2010
    ..We plan to test the effects of cognitive behavioral therapy, on sleep, daytime symptoms, and function middle-aged and older adults who have heart failure. ..
  65. Sleep and Functional Performance in Heart Failure
    Nancy Redeker; Fiscal Year: 2003
    ..SEM will be used to evaluate the factor structure of the sleep disturbance construct and serve as a tool to explore the direct and indirect pathways linking the major study variables. ..
  66. Sleep and Functional Performance in Heart Failure
    Nancy Redeker; Fiscal Year: 2006
    ..SEM will be used to evaluate the factor structure of the sleep disturbance construct and serve as a tool to explore the direct and indirect pathways linking the major study variables. ..
  67. Sleep and Functional Performance in Heart Failure
    Nancy Redeker; Fiscal Year: 2006
    ..SEM will be used to evaluate the factor structure of the sleep disturbance construct and serve as a tool to explore the direct and indirect pathways linking the major study variables. ..
  68. Sleep and Functional Performance in Heart Failure
    Nancy Redeker; Fiscal Year: 2005
    ..SEM will be used to evaluate the factor structure of the sleep disturbance construct and serve as a tool to explore the direct and indirect pathways linking the major study variables. ..
  69. Sleep and Functional Performance in Heart Failure
    Nancy Redeker; Fiscal Year: 2004
    ..SEM will be used to evaluate the factor structure of the sleep disturbance construct and serve as a tool to explore the direct and indirect pathways linking the major study variables. ..
  70. Cognitive Behavioral Therapy for Insomnia in Stable Heart Failure
    Nancy Redeker; Fiscal Year: 2009
    ..We plan to test the effects of cognitive behavioral therapy, on sleep, daytime symptoms, and function middle-aged and older adults who have heart failure. ..
  71. The Genetics of Metabolic Dysfunction in Sleep Apnea
    Sanjay Patel; Fiscal Year: 2008
    ..These association studies will be repeated in an independent OSA population recruited from a clinical trial to ensure generalizability of findings. ..
  72. Cardiovascular Sequellae of Respiratory Muscle Work
    Jerome Dempsey; Fiscal Year: 2008
    ....
  73. A randomized trial of bariatric surgery for the treatment of sleep apnea
    Sanjay R Patel; Fiscal Year: 2010
    ..In this study, we will conduct a trial comparing the ability of CPAP and bariatric surgery to treat sleep apnea in patients who have severe sleep apnea and morbid obesity. ..
  74. Air Pollution and Cardiac Risk: Mechanisms & Time-course
    Duanping Liao; Fiscal Year: 2008
    ..5 affects the cardiac system, and identify factors that lead to differential susceptibility to PM, and guide regulatory agencies in designing air pollution control standards. ..
  75. Biomarkers of the Response to CBT for Insomnia in Major Depression
    Andrew D Krystal; Fiscal Year: 2010
    ..End of Abstract) ..
  76. Impact of sleepiness on heart failure self-care
    Barbara Riegel; Fiscal Year: 2008
    ..This study is expected to expand existing knowledge and clarify our understanding of the mechanisms linking EDS, failed self-care, poor HRQL, and unplanned hospitalizations in persons with heart failure. ..
  77. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2009
    ..We hypothesize that that volume control can improve BP and antihypertensive therapy can regress left ventricular hypertrophy in long-term hemodialysis patients. ..
  78. Air Pollution and Cardiac Risk: Mechanisms & Time-course
    Duanping Liao; Fiscal Year: 2009
    ..5 affects the cardiac system, and identify factors that lead to differential susceptibility to PM, and guide regulatory agencies in designing air pollution control standards. ..
  79. Pathophysiology of OSAS in Obese Children 8-17 Years Old
    Raanan Arens; Fiscal Year: 2009
    ..This study will determine the anatomic and functional risk factors related to obesity and OSAS in inner city children 8-17 years of age using physiological studies coupled with novel imaging and computerized methodology. ..
  80. Sleep and Child Developmental Outcomes: Physiological and Contextual Influences
    MONA M EL SHEIKH; Fiscal Year: 2010
    ....
  81. MCI, APOE and Sleep Apnea: Effects on Cognition
    RUTH O HARA; Fiscal Year: 2009
    ..Reducing cognitive impairment and delaying the onset of AD has significant clinical and economic benefits. Thus, the answer to this question could significantly enhance our therapeutic approach to cognitive impairment in older adults. ..
  82. Child Regulation and Exposure to Marital Violence
    Mona El Sheikh; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  83. Markers of Autonomic and Metabolic Control in Childhood Obesity
    MICHAEL KHOO; Fiscal Year: 2007
    ....
  84. Sleep and Nocturnal Endocrine Function in MDMA User
    Una McCann; Fiscal Year: 2007
    ..Results from the proposed studies will help better define the functional consequences of MDMA exposure in humans, and could shed light on the roles of 5-HT and DA in sleep and nocturnal endocrine function. ..
  85. Nicotine induced neuroplasticity in the carotid body
    Estelle Gauda; Fiscal Year: 2004
    ....
  86. PET Imaging MDMA Neurotoxicity
    Una McCann; Fiscal Year: 2005
    ..g., dementia, Parkinsonism, depression/anxiety). In addition, the proposed 18FDG studies will address the question of if MDMA exposure leads to altered brain function at the most fundamental level, glucose utilization. ..
  87. Impact of CPAP on Functional Outcomes in Milder OSA
    Terri Weaver; Fiscal Year: 2005
    ..Secondary aims of the study are: 1) to examine whether CPAP also improves daytime sleepiness; 2) to determine whether CPAP can reduce nocturnal blood pressure to lower the risk for stroke and hypertension linked to OSA. ..
  88. Exploration of ETS Effects on Child Behavior and Sleep
    Kimberly Yolton; Fiscal Year: 2005
    ..abstract_text> ..
  89. HEART RATE VARIABILITY IN SLEEP-DISORDERED BREATHING
    MICHAEL KHOO; Fiscal Year: 2005
    ....
  90. Cardiovascular Sequellae of Respiratory Muscle Work
    Jerome Dempsey; Fiscal Year: 2004
    ....
  91. PET Imaging MDMA Neurotoxicity
    Una McCann; Fiscal Year: 2002
    ..g., dementia, Parkinsonism, depression/anxiety). In addition, the proposed 18FDG studies will address the question of if MDMA exposure leads to altered brain function at the most fundamental level, glucose utilization. ..
  92. Nicotine induced neuroplasticity in the carotid body
    Estelle Gauda; Fiscal Year: 2001
    ....
  93. HUMAN VENTILATORY ADAPTATION
    Jerome Dempsey; Fiscal Year: 1980
    ....
  94. MCI, APOE and Sleep Apnea: Effects on Cognition
    RUTH O HARA; Fiscal Year: 2006
    ..Reducing cognitive impairment and delaying the onset of AD has significant clinical and economic benefits. Thus, the answer to this question could significantly enhance our therapeutic approach to cognitive impairment in older adults. ..