sleep apnea syndromes

Summary

Summary: Disorders characterized by multiple cessations of respirations during sleep that induce partial arousals and interfere with the maintenance of sleep. Sleep apnea syndromes are divided into central (see SLEEP APNEA, CENTRAL), obstructive (see SLEEP APNEA, OBSTRUCTIVE), and mixed central-obstructive types.

Top Publications

  1. ncbi Prospective study of the association between sleep-disordered breathing and hypertension
    P E Peppard
    Department of Preventive Medicine, University of Wisconsin School of Medicine, Madison 53705, USA
    N Engl J Med 342:1378-84. 2000
  2. ncbi A new method for measuring daytime sleepiness: the Epworth sleepiness scale
    M W Johns
    Sleep Disorders Unit, Epworth Hospital, Melbourne, Victoria, Australia
    Sleep 14:540-5. 1991
  3. ncbi Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study
    E Shahar
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
    Am J Respir Crit Care Med 163:19-25. 2001
  4. ncbi Sleep-disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health Study
    Naresh M Punjabi
    Division of Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD21224, USA
    Am J Epidemiol 160:521-30. 2004
  5. pmc Sleep-disordered breathing and mortality: a prospective cohort study
    Naresh M Punjabi
    Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Med 6:e1000132. 2009
  6. doi Sleep apnea and cardiovascular disease: an American Heart Association/american College Of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on
    Virend K Somers
    Circulation 118:1080-111. 2008
  7. ncbi Longitudinal study of moderate weight change and sleep-disordered breathing
    P E Peppard
    University of Wisconsin School of Medicine, Department of Preventive Medicine, 502 N Walnut St, Madison, WI 53705, USA
    JAMA 284:3015-21. 2000
  8. ncbi Estimation of the clinically diagnosed proportion of sleep apnea syndrome in middle-aged men and women
    T Young
    Department of Preventive Medicine, University of Wisconsin-Madison 53705, USA
    Sleep 20:705-6. 1997
  9. pmc Obstructive sleep apnoea syndrome as a risk factor for hypertension: population study
    P Lavie
    Sleep Laboratory, Bruce Rappaport Faculty of Medicine, Israel Institute of Technology, Haifa, Israel
    BMJ 320:479-82. 2000
  10. pmc Sleep. 4: Sleepiness, cognitive function, and quality of life in obstructive sleep apnoea/hypopnoea syndrome
    H M Engleman
    Edinburgh Sleep Centre, Unit of Respiratory Medicine, University of Edinburgh, Lauriston Place, Edinburgh EH3 9YW, Scotland, UK
    Thorax 59:618-22. 2004

Research Grants

  1. Treatment of Sleep Apnea using a Positive Airway Pressure Rebreathing Modulator
    Matthew D Tarler; Fiscal Year: 2011
  2. Stimulation Induced Modulation of Sleep
    MATTHEW TARLER; Fiscal Year: 2009
  3. Effects of aging on sleep architecture
    Naresh Punjabi; Fiscal Year: 2006
  4. EARLY IDENTIFICATION AND TREATMENT OF SLEEP APNEA
    Naresh Punjabi; Fiscal Year: 2003
  5. THE SLEEP HEART HEALTH STUDY
    Naresh Punjabi; Fiscal Year: 2007
  6. Longtitudinal Changes in Sleep Structure: Implications for Health Outcomes
    Naresh Punjabi; Fiscal Year: 2010
  7. WORKING MEMORY IN OBSTRUCTIVE SLEEP APNEA-AN fMRI STUDY
    Robert Thomas; Fiscal Year: 2006
  8. ECG-derived estimators of sleep physiology
    Robert Thomas; Fiscal Year: 2006
  9. THE ROLE OF CYTOKINES IN SLEEPINESS AND SLEEP APNEA
    Alexandros Vgontzas; Fiscal Year: 2009
  10. NEURAL CONTROL OF CARDIORESPIRATORY FUNCTION
    Ronald Harper; Fiscal Year: 2004

Detail Information

Publications266 found, 100 shown here

  1. ncbi Prospective study of the association between sleep-disordered breathing and hypertension
    P E Peppard
    Department of Preventive Medicine, University of Wisconsin School of Medicine, Madison 53705, USA
    N Engl J Med 342:1378-84. 2000
    ....
  2. ncbi A new method for measuring daytime sleepiness: the Epworth sleepiness scale
    M W Johns
    Sleep Disorders Unit, Epworth Hospital, Melbourne, Victoria, Australia
    Sleep 14:540-5. 1991
    ..ESS scores of patients who simply snored did not differ from controls...
  3. ncbi Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study
    E Shahar
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
    Am J Respir Crit Care Med 163:19-25. 2001
    ..99-1.62), respectively. These findings are compatible with modest to moderate effects of sleep-disordered breathing on heterogeneous manifestations of CVD within a range of AHI values that are considered normal or only mildly elevated...
  4. ncbi Sleep-disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health Study
    Naresh M Punjabi
    Division of Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD21224, USA
    Am J Epidemiol 160:521-30. 2004
    ..The results of this study suggest that SDB is independently associated with glucose intolerance and insulin resistance and may lead to type 2 diabetes mellitus...
  5. pmc Sleep-disordered breathing and mortality: a prospective cohort study
    Naresh M Punjabi
    Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Med 6:e1000132. 2009
    ....
  6. doi Sleep apnea and cardiovascular disease: an American Heart Association/american College Of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on
    Virend K Somers
    Circulation 118:1080-111. 2008
  7. ncbi Longitudinal study of moderate weight change and sleep-disordered breathing
    P E Peppard
    University of Wisconsin School of Medicine, Department of Preventive Medicine, 502 N Walnut St, Madison, WI 53705, USA
    JAMA 284:3015-21. 2000
    ..Excess body weight is positively associated with sleep-disordered breathing (SDB), a prevalent condition in the US general population. No large study has been conducted of the longitudinal association between SDB and change in weight...
  8. ncbi Estimation of the clinically diagnosed proportion of sleep apnea syndrome in middle-aged men and women
    T Young
    Department of Preventive Medicine, University of Wisconsin-Madison 53705, USA
    Sleep 20:705-6. 1997
    ..These findings provide a baseline for assessing health care resource needs for sleep apnea...
  9. pmc Obstructive sleep apnoea syndrome as a risk factor for hypertension: population study
    P Lavie
    Sleep Laboratory, Bruce Rappaport Faculty of Medicine, Israel Institute of Technology, Haifa, Israel
    BMJ 320:479-82. 2000
    ..To assess whether sleep apnoea syndrome is an independent risk factor for hypertension...
  10. pmc Sleep. 4: Sleepiness, cognitive function, and quality of life in obstructive sleep apnoea/hypopnoea syndrome
    H M Engleman
    Edinburgh Sleep Centre, Unit of Respiratory Medicine, University of Edinburgh, Lauriston Place, Edinburgh EH3 9YW, Scotland, UK
    Thorax 59:618-22. 2004
    ..The evidence is compatible with hypotheses that these deficits are reversible with treatment, particularly for patients with severe disease...
  11. ncbi Practice parameters for the indications for polysomnography and related procedures: an update for 2005
    Clete A Kushida
    Stanford University Center of Excellence for Sleep Disorders, Stanford, CA, USA
    Sleep 28:499-521. 2005
    ....
  12. ncbi Incidence of sleep-disordered breathing in an urban adult population: the relative importance of risk factors in the development of sleep-disordered breathing
    Peter V Tishler
    Veterans Affairs Boston Healthcare System and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    JAMA 289:2230-7. 2003
    ..Sleep-disordered breathing (SDB) is both prevalent and associated with serious chronic illness. The incidence of SDB and the effect of risk factors on this incidence are unknown...
  13. pmc Sleep-disordered breathing in community-dwelling elderly
    S Ancoli-Israel
    Department of Psychiatry, University of California, San Diego
    Sleep 14:486-95. 1991
    ..Despite statistical significance, all of the associations between interview variables and apnea indices were small. No combination of demographic variables and symptoms allowed highly reliable prediction of AI or RDI...
  14. ncbi The Sleep Heart Health Study: design, rationale, and methods
    S F Quan
    Department of Medicine and Respiratory Sciences Center, University of Arizona, Tucson 85724, USA
    Sleep 20:1077-85. 1997
    ..The study provides sufficient statistical power for assessing OSA and other SDB as risk factors for major cardiovascular events, including myocardial infarction and stroke...
  15. ncbi Current opinions and clinical practice in the titration of oral appliances in the treatment of sleep-disordered breathing
    Marijke Dieltjens
    Clinical Department of Special Care Dentistry, University of Antwerp UA and Antwerp University Hospital UZA, Edegem, Antwerp, Belgium
    Sleep Med Rev 16:177-85. 2012
    ..At present, a consensus exists that an optimal titration protocol is of primary importance to achieve a successful treatment outcome with an MRA. To date however, there is no consensus on how to define the optimal titration protocol...
  16. ncbi Longitudinal association of sleep-related breathing disorder and depression
    Paul E Peppard
    Department of Population Health Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Arch Intern Med 166:1709-15. 2006
    ..This population-based epidemiological study assesses SRBD as a longitudinal predictor of depression...
  17. ncbi Continuous positive airway pressure treatment of mild to moderate obstructive sleep apnea reduces cardiovascular risk
    Nikolaus J Buchner
    Department of Internal Medicine I, Marienhospital Herne, Ruhr University Bochum, Hoelkeskampring 40, D 44625 Herne, Germany
    Am J Respir Crit Care Med 176:1274-80. 2007
    ..Obstructive sleep apnea (OSA) is linked to increased cardiovascular risk, but the impact of mild forms of OSA and their treatment on cardiovascular outcomes remains controversial...
  18. ncbi Validation of a Chinese version of the Epworth sleepiness scale
    Ning Hung Chen
    Department of Pulmonary and Critical Care Medicine, Sleep Center, Chang Gung Memorial Hospital, Taipei, Taiwan, ROC
    Qual Life Res 11:817-21. 2002
    ..The CESS could be used to advantage among other Mandarin-speaking subjects as a standardised screening test of sleepiness in daily life...
  19. ncbi Sleep apnoea in heart failure
    R Schulz
    University of Giessen Lung Center, Klinikstr 36, 35392 Giessen, and Charité University Hospital Berlin, Sleep Disorders Centre, Department of Cardiology Pulmonary Medicine, Germany
    Eur Respir J 29:1201-5. 2007
    ..This diagnostic approach should probably be adopted for all of these patients irrespective of the presence of sleep-related symptoms...
  20. ncbi Non-CPAP therapies in obstructive sleep apnoea: mandibular advancement device therapy
    Marie Marklund
    Dept of Orthodontics, Faculty of Medicine, Umea University, Umea, Sweden
    Eur Respir J 39:1241-7. 2012
    ..The treatment must be followed up and the device adjusted or exchanged in relation to the outcome...
  21. pmc Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women
    Kristine Yaffe
    Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94121, USA
    JAMA 306:613-9. 2011
    ..Cross-sectional studies have linked sleep-disordered breathing to poor cognition; however, it remains unclear whether sleep-disordered breathing precedes cognitive impairment in older adults...
  22. pmc Central cholinergic regulation of respiration: nicotinic receptors
    Xuesi M Shao
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
    Acta Pharmacol Sin 30:761-70. 2009
    ....
  23. pmc A controlled study of sleep related disordered breathing in obese children
    Y K Wing
    Department of Psychiatry, Prince of Wales and Shatin Hospital, Shatin, The Chinese University of Hong Kong, Hong Kong SAR, China
    Arch Dis Child 88:1043-7. 2003
    ..Unlike the adult sleep related disordered breathing (SDB) patients who are typically obese, the relation between obesity and childhood SDB is not clear...
  24. ncbi Description and validation of the apnea risk evaluation system: a novel method to diagnose sleep apnea-hypopnea in the home
    Philip R Westbrook
    Advanced Brain Monitoring, Inc, 2850 Pio Pico Dr, Suite A, Carlsbad, CA 92008, USA
    Chest 128:2166-75. 2005
    ..To evaluate the accuracy and practicality of the Apnea Risk Evaluation System (ARES; Advanced Brain Monitoring; Carlsbad, CA), a limited-channel system for diagnosing sleep apnea/hypopnea in the home...
  25. ncbi Mortality in sleep apnea patients: a multivariate analysis of risk factors
    P Lavie
    Sleep Laboratory and Unit of Pulmonary Diseases, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa
    Sleep 18:149-57. 1995
    ..Age, BMI and hypertension predicted MI deaths in addition to lung disease. These results were interpreted to suggest that SAS affects death indirectly, most probably by being a risk factor for hypertension...
  26. ncbi Is obstructive sleep apnea a problem in Parkinson's disease?
    Valerie Cochen De Cock
    Sleep Disorders Unit, Pitie Salpetriere Hospital, APHP, Paris, France
    Sleep Med 11:247-52. 2010
    ..Upper airway dysfunction in PD may promote obstructive sleep apnea. However, the frequency and clinical relevance of sleep-disordered breathing in PD remains unclear...
  27. ncbi Excess weight and sleep-disordered breathing
    Terry Young
    Department of Population Health Sciences, University of Wisconsin Madison, USA
    J Appl Physiol (1985) 99:1592-9. 2005
    ..Clearly, if the expanding epidemic of obesity seen in the United States continues, the prevalence of SDB will almost certainly increase, along with the proportion of SDB attributable to obesity...
  28. pmc Association of sleep-disordered breathing and the occurrence of stroke
    Michael Arzt
    Toronto General Hospital University Health Network, 9N 943, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada
    Am J Respir Crit Care Med 172:1447-51. 2005
    ..However, these studies either used surrogate markers of sleep-disordered breathing or could not, due to cross-sectional design, address the temporal relationship between sleep-disordered breathing and stroke...
  29. ncbi Short-term variability of respiration and sleep during unattended nonlaboratory polysomnography--the Sleep Heart Health Study. [corrected]
    Stuart F Quan
    Arizona Respiratory Center and Department of Medicine, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Sleep 25:843-9. 2002
    ..To determine the short-term variability of indices of disturbed respiration and sleep during 2 nights of unattended nonlaboratory polysomnography conducted several months apart...
  30. ncbi Access to diagnosis and treatment of patients with suspected sleep apnea
    W Ward Flemons
    Faculty of Medicine, University of Calgary, Alberta, Canada
    Am J Respir Crit Care Med 169:668-72. 2004
  31. ncbi A survey screen for prediction of apnea
    G Maislin
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia 19104-4283, USA
    Sleep 18:158-66. 1995
    ..79 (p < 0.0001). For BMI alone, it was 0.73, and for an index measuring the self-report of the frequency of apnea symptoms, it was 0.70. The multivariable apnea risk index has potential utility in clinical settings...
  32. ncbi ROS signaling in systemic and cellular responses to chronic intermittent hypoxia
    Nanduri R Prabhakar
    Center for Systems Biology, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Antioxid Redox Signal 9:1397-403. 2007
    ....
  33. ncbi Sleep apnoea syndrome is highly prevalent in acromegaly and only partially reversible after biochemical control of the disease
    Maria Vittoria Davi'
    Clinic of Internal Medicine D, Department of Biomedical and Surgical Sciences, University of Verona, Policlinico GB Rossi, Verona, Italy
    Eur J Endocrinol 159:533-40. 2008
    ..Whether sleep apnoea syndrome (SAS) subsides after biochemical and clinical remission of acromegaly is controversial...
  34. ncbi Pregnancy and fetal outcomes of symptoms of sleep-disordered breathing
    G Bourjeily
    Dept of Medicine, Women and Infants Hospital of Rhode Island, 100 Dudley Street, 3rd Floor, Providence, RI 02905, USA
    Eur Respir J 36:849-55. 2010
    ..Symptoms of SDB are common in pregnancy and associated with a higher likelihood of gestational hypertensive disorders, gestational diabetes and unplanned Caesarean deliveries...
  35. ncbi Diabetes and sleep disturbances: findings from the Sleep Heart Health Study
    Helaine E Resnick
    MedStar Research Institute, Hyattsville, Maryland 20783, USA
    Diabetes Care 26:702-9. 2003
    ..To test the hypothesis that diabetes is independently associated with sleep-disordered breathing (SDB), and in particular that diabetes is associated with sleep abnormalities of a central, rather than obstructive, nature...
  36. ncbi Marked decrease in sleepiness in patients with sleep apnea by etanercept, a tumor necrosis factor-alpha antagonist
    A N Vgontzas
    Department of Psychiatry H073, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 89:4409-13. 2004
    ..9 vs. 3.1 min), suggests that proinflammatory cytokines contribute to the pathogenesis of OSA/sleepiness...
  37. ncbi Increased incidence of cardiovascular disease in middle-aged men with obstructive sleep apnea: a 7-year follow-up
    Yuksel Peker
    Sleep Laboratory, Department of Pulmonary Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Am J Respir Crit Care Med 166:159-65. 2002
    ..Furthermore, efficient treatment of OSA reduces the excess CVD risk and may be considered also in relatively mild OSA without regard to daytime sleepiness...
  38. pmc Prevalence and types of sleep disturbances acutely after traumatic brain injury
    Vani Rao
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry, Baltimore, MD, USA
    Brain Inj 22:381-6. 2008
    ..To assess the prevalence of and risk factors for sleep disturbances in the acute post-traumatic brain injury (TBI) period...
  39. ncbi The significance and outcome of continuous positive airway pressure-related central sleep apnea during split-night sleep studies
    Tarek Dernaika
    University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Chest 132:81-7. 2007
    ....
  40. pmc Are sleep problems under-recognised in general practice?
    S Blunden
    University of South Australia, Centre for Sleep Research, 5th Floor, Basil Hetzel Institute, Queen Elizabeth Hospital, Woodville Road, Woodville, SA 5011, Australia
    Arch Dis Child 89:708-12. 2004
    ..To evaluate the frequency of sleep problems in Australian children aged 4.5-16.5 years, and to determine whether the frequency of sleep problems on questionnaire predicts the reporting of sleep problems at consultation...
  41. ncbi Titrated mandibular advancement versus positive airway pressure for sleep apnoea
    F Gagnadoux
    Departement de Pneumologie, CHU, Angers, France
    Eur Respir J 34:914-20. 2009
    ..Both treatments improved functional outcomes to a similar degree. One-night titration of MAd had a low negative predictive value for treatment success...
  42. ncbi Health, social and economical consequences of sleep-disordered breathing: a controlled national study
    Poul Jennum
    Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Faculty of Health Sciences, University of Copenhagen, Glostrup Hospital, DK 2600 Glostrup, Denmark
    Thorax 66:560-6. 2011
    ..The objective direct and indirect costs of sleep-disordered breathing (snoring, sleep apnoea (SA) and obesity hypoventilation syndrome (OHS)) and the treatment are incompletely described...
  43. ncbi The effect of chronic or intermittent hypoxia on cognition in childhood: a review of the evidence
    Joel L Bass
    Department of Pediatrics, Newton Wellesley Hospital, MassGeneral Hospital for Children, Harvard Medical School, Newton, Massachusetts 02462, USA
    Pediatrics 114:805-16. 2004
    ....
  44. ncbi Effects of nasal CPAP treatment on insulin resistance, lipid profile, and plasma leptin in sleep apnea
    Caglar Cuhadaroglu
    Department of Chest Diseases, Istanbul Faculty of Medicine, Istanbul University, Gogus Hastaliklari Anabilim Dali, Istanbul, Turkey
    Lung 187:75-81. 2009
    ....
  45. ncbi Effect of transsphenoidal surgery on sleep apnoea in acromegaly
    Lisa Sze
    Division of Endocrinology and Diabetes, Department of Internal Medicine, Kantonsspital St Gallen, 9007 St Gallen, Switzerland
    Eur J Endocrinol 156:321-9. 2007
    ..The aim of this study was to assess the prevalence and risk factors of SAS in acromegaly and to analyze the effect of transsphenoidal adenomectomy on SAS and cardiovascular risk factors...
  46. ncbi Sleep-related breathing disorders are associated with ventricular arrhythmias in patients with an implantable cardioverter-defibrillator
    Joachim Fichter
    Department of Internal Medicine V, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Chest 122:558-61. 2002
    ....
  47. ncbi Measuring agreement between diagnostic devices
    W Ward Flemons
    Faculty of Medicine, University of Calgary, Calgary, AB, Canada
    Chest 124:1535-42. 2003
    ..Each approach has advantages and limitations, which are highlighted in this review...
  48. ncbi Effect of nasal continuous positive airway pressure during sleep on 24-hour blood pressure in obstructive sleep apnea
    I Wilcox
    Department of Medicine, University of Sydney, Australia
    Sleep 16:539-44. 1993
    ....
  49. ncbi Analysis of the interbeat interval increment to detect obstructive sleep apnoea/hypopnoea
    F Roche
    Department of Clinical Physiology and Exercise, Faculty of Medicine, Jacques Lisfranc University Jean Monnet, Saint Etienne, France, and Sleep Laboratory, Department of Psychiatry, University Hospital, Geneva, Switzerland
    Eur Respir J 29:1206-11. 2007
    ..Higher power spectral density of the interbeat interval increment of very low frequencies may also indicate disrupted sleep in the absence of clear clinical symptoms of sleep apnoea/hypopnoea syndrome...
  50. ncbi Invited review: Physiological consequences of intermittent hypoxia: systemic blood pressure
    E C Fletcher
    Division of Respiratory, Critical Care and Environmental Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    J Appl Physiol (1985) 90:1600-5. 2001
    ..It appears that adrenergic and renin-angiotensin system overactivity contributes to the early chronic elevated blood pressure in rat intermittent hypoxia and perhaps to human hypertension associated with obstructive sleep apnea...
  51. pmc Sleep disordered breathing with excessive daytime sleepiness is a risk factor for mortality in older adults
    Nalaka S Gooneratne
    Division of Geriatric Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Sleep 34:435-42. 2011
    ..This study examined the relationship between daytime sleepiness, SDB, self-report sleep parameters, and mortality in older adults...
  52. ncbi Outcome of COPD patients with mild daytime hypoxaemia with or without sleep-related oxygen desaturation
    A Chaouat
    Dept of Pneumology, University Hospital, Strasbourg, France
    Eur Respir J 17:848-55. 2001
    ..Such isolated nocturnal hypoxaemia or sleep-related worsening of moderate daytime hypoxaemia does not appear to favour the development of pulmonary hypertension, nor to lead to worsening of daytime blood gases...
  53. ncbi Continuous analysis and monitoring of snores and their relationship to the apnea-hypopnea index
    Jose Antonio Fiz
    Hospital de Navarra, Fundación Miguel Servet, Pamplona, Navarra, Spain
    Laryngoscope 120:854-62. 2010
    ....
  54. ncbi Home diagnosis of sleep apnea: a systematic review of the literature. An evidence review cosponsored by the American Academy of Sleep Medicine, the American College of Chest Physicians, and the American Thoracic Society
    W Ward Flemons
    Faculty of Medicine, University of Calgary, Calgary, AB, Canada
    Chest 124:1543-79. 2003
  55. ncbi Nocturnal haemodialysis increases pharyngeal size in patients with sleep apnoea and end-stage renal disease
    Jaime M Beecroft
    Department of Medicine, University of Calgary, Alberta, Canada
    Nephrol Dial Transplant 23:673-9. 2008
    ..We hypothesized that NHD increases pharyngeal cross-sectional area and that this is associated with an improvement in sleep apnoea...
  56. ncbi Systematic comparison of different algorithms for apnoea detection based on electrocardiogram recordings
    T Penzel
    Department of Respiratory Critical Care Medicine, Hospital of Philipps University, Marburg, Germany
    Med Biol Eng Comput 40:402-7. 2002
    ..Four of these algorithms achieved perfect scores of 100% in the first part of the study, and two achieved an accuracy of over 90% in the second part of the study...
  57. pmc Green tea catechin polyphenols attenuate behavioral and oxidative responses to intermittent hypoxia
    Isabel C Burckhardt
    Kosair Children s Hospital Research Institute, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
    Am J Respir Crit Care Med 177:1135-41. 2008
    ..We hypothesized that green tea catechin polyphenols (GTPs) may attenuate IH-induced neurobehavioral deficits by reducing IH-induced NADPH oxidase expression, lipid peroxidation, and inflammation...
  58. ncbi Sleep-disordered breathing as a risk factor for cerebrovascular disease: a case-control study in patients with transient ischemic attacks
    Nigel McArdle
    Department of Medicine, University of Edinburgh, Royal Infirmary, Edinburgh, UK
    Stroke 34:2916-21. 2003
    ..We explored this relationship in transient ischemic attack (TIA) patients because they are less likely than stroke patients to have OSAH as a consequence of cerebrovascular disease...
  59. ncbi Health care utilization in males with obstructive sleep apnea syndrome two years after diagnosis and treatment
    A Bahammam
    Sleep Disorders Centre, St. Boniface General Hospital Research Centre, Department of Medicine, Winnipeg, Manitoba
    Sleep 22:740-7. 1999
    ..53+0.14 per patient per year (p=0.034) were significant while in the PNAT group they were not. CONCLUSIONS: Adherence to treatment in patients with OSAS results in a significant reduction in physician claims and hospital stays...
  60. pmc Prospective study of sleep-disordered breathing and hypertension: the Sleep Heart Health Study
    GEORGE T O'CONNOR
    Pulmonary Center, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
    Am J Respir Crit Care Med 179:1159-64. 2009
    ..Cross-sectional epidemiologic studies show an association between sleep-disordered breathing and hypertension, but only one cohort study has examined sleep-disordered breathing as a risk factor for incident hypertension...
  61. ncbi Prevalence of symptoms and risk of sleep apnea in primary care
    Nikolaus C Netzer
    The Center for Sleep Disorders Research, Case Western Reserve University, Cleveland, OH, USA
    Chest 124:1406-14. 2003
    ..To obtain prevalence estimates for key symptoms and features that can indicate the presence of obstructive sleep apnea (OSA) in a broad range of primary care settings...
  62. ncbi Sleep-disordered breathing occurs frequently in stable outpatients with congestive heart failure
    Katherine Ferrier
    WellSleep, Department of Medicine, Wellington School of Medicine and Health Sciences, New Zealand
    Chest 128:2116-22. 2005
    ..The prevalence, type, and severity of SDB in unselected stable outpatients with CHF are unknown...
  63. pmc Alterations in Glucose Disposal in Sleep-disordered Breathing
    Naresh M Punjabi
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 179:235-40. 2009
    ..However, data on whether SDB alters in vivo kinetics of glucose and insulin are lacking...
  64. ncbi Adaptive servoventilation improves cardiac function in patients with chronic heart failure and Cheyne-Stokes respiration
    Olaf Oldenburg
    Department of Cardiology, Heart and Diabetes Centre North Rhine Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany
    Eur J Heart Fail 10:581-6. 2008
    ..Adaptive servoventilation (ASV) was recently introduced to treat CSR in CHF. The aim of this study was to investigate the effects of ASV on CSR and CHF parameters...
  65. ncbi Daytime sleepiness and hyperactivity in children with suspected sleep-disordered breathing
    Ma Cecilia S Melendres
    Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Pediatrics 114:768-75. 2004
    ..Furthermore, we hypothesized that overnight polysomnographic parameters correlated with sleepiness and hyperactivity...
  66. ncbi Effect of nocturnal nasal continuous positive airway pressure on blood pressure in obstructive sleep apnea
    Lydia A Bazzano
    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA
    Hypertension 50:417-23. 2007
    ..38 to -0.05). Net reductions in blood pressure were not statistically different between daytime and nighttime. These results indicate that CPAP decreases blood pressure among those with OSA and may help prevent hypertension...
  67. ncbi Positive effect of CPAP treatment on the control of difficult-to-treat hypertension
    M A Martínez-García
    Pneumology Unit, Requena General Hospital, Valencia, Spain
    Eur Respir J 29:951-7. 2007
    ..Continuous positive airway pressure treatment significantly reduces systolic blood pressure, particularly at night, and normalises the nocturnal pressure pattern in patients with difficult-to-control hypertension and sleep apnoea...
  68. ncbi Endogenous excitatory drive modulating respiratory muscle activity across sleep-wake states
    Erin Chan
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 174:1264-73. 2006
    ..However, a neurotransmitter substrate mediating respiratory muscle activation across sleep-wake states has not been identified...
  69. ncbi Hypothalamic-pituitary-adrenal axis activation in obstructive sleep apnea: the effect of continuous positive airway pressure therapy
    David E Henley
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol BS1 3NY, United Kingdom
    J Clin Endocrinol Metab 94:4234-42. 2009
    ..We hypothesized that these may result from OSA-induced perturbations of endogenous ultradian hypothalamic-pituitary-adrenal axis activity...
  70. ncbi Variation of C-reactive protein levels in adolescents: association with sleep-disordered breathing and sleep duration
    Emma K Larkin
    Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Triangle Building Suite 260, 10400 Euclid Ave, Cleveland, OH 44106, USA
    Circulation 111:1978-84. 2005
    ..The goal of this study was to quantify the associations of SDB, sleep duration, and CRP in adolescents to better understand the role of SDB in CVD risk...
  71. ncbi Spectral oscillations of RR intervals in sleep apnoea/hypopnoea syndrome patients
    K Dingli
    Respiratory Medicine, University of Edinburgh, Edinburgh, UK
    Eur Respir J 22:943-50. 2003
    ..The recurrent nocturnal fluctuations of sympathovagal balance and the overall increase of nocturnal autonomic activity may be of importance in the development of cardiovascular disease in sleep apnoea patients...
  72. pmc A mediation model linking body weight, cognition, and sleep-disordered breathing
    Karen Spruyt
    Department of Pediatrics, Pritzker School of Medicine, The University of Chicago, IL 60637, USA
    Am J Respir Crit Care Med 185:199-205. 2012
    ....
  73. ncbi Neurobehavioral morbidity associated with disordered breathing during sleep in children: a comprehensive review
    Dean W Beebe
    Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, OH 45229, USA
    Sleep 29:1115-34. 2006
    ..To comprehensively review research on the association between childhood sleep-disordered breathing (SDB) and neurobehavioral functioning...
  74. pmc A controlled trial of CPAP therapy on metabolic control in individuals with impaired glucose tolerance and sleep apnea
    Tanya G Weinstock
    Department of Medicine, Brigham and Women s Hospital and Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Sleep 35:617-625B. 2012
    ..To address whether treatment of sleep apnea improves glucose tolerance...
  75. ncbi Daytime Cheyne-Stokes respiration in ambulatory patients with severe congestive heart failure is associated with increased mortality
    Thomas Brack
    Division of Pulmonary Medicine, University Hospital Zurich, Switzerland
    Chest 132:1463-71. 2007
    ..Daytime CSR supposedly poses an even greater risk, but its prevalence and prognostic importance remain elusive. Therefore, we investigated the circadian prevalence of CSR and its influence on survival in patients with heart failure...
  76. ncbi Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia
    A N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University, Hershey 17033, USA
    J Clin Endocrinol Metab 85:1151-8. 2000
    ..We conclude that there is a strong independent association among sleep apnea, visceral obesity, insulin resistance and hypercytokinemia, which may contribute to the pathological manifestations and somatic sequelae of this condition...
  77. pmc Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: implications for recurrent apneas
    Ying Jie Peng
    Department of Physiology and Biophysics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 100:10073-8. 2003
    ..The sensory LTF may contribute to persistent reflex activation of sympathetic nerve activity and blood pressure in recurrent apnea patients experiencing CIH...
  78. ncbi Sleep apnea in early and advanced chronic kidney disease: Kaiser Permanente Southern California cohort
    John J Sim
    Division of Nephrology and Hypertension, Kaiser Permanente Los Angeles Medical Center, 4700 Sunset Blvd, Los Angeles, CA 90027, USA
    Chest 135:710-6. 2009
    ..This study sought to determine whether an association exists between SA and early stages of chronic kidney disease (CKD) where SA may represent an important comorbidity and potential risk factor in kidney disease...
  79. ncbi Sleep in overweight adolescents: shorter sleep, poorer sleep quality, sleepiness, and sleep-disordered breathing
    Dean W Beebe
    Division of Behavioral Medicine and Clinical Psychology MLC 3015, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    J Pediatr Psychol 32:69-79. 2007
    ..To document the sleep of overweight adolescents and to explore the degree to which weight-related sleep pathology might account for diminished psychosocial outcome...
  80. ncbi Variation in symptoms of sleep-disordered breathing with race and ethnicity: the Sleep Heart Health Study
    GEORGE T O'CONNOR
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118 2394, USA
    Sleep 26:74-9. 2003
    ..To examine the relation of sleep-related symptoms to race and ethnicity in a diverse sample of middle-aged and older men and women...
  81. ncbi Heart failure and sleep apnoea: to sleep perchance to dream
    Susana Ferreira
    Faculdade Medicina do Porto, Portugal
    Eur J Heart Fail 8:227-36. 2006
    ....
  82. ncbi High prevalence of unrecognized sleep apnoea in drug-resistant hypertension
    A G Logan
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and University of Toronto, Toronto, Ontario, Canada
    J Hypertens 19:2271-7. 2001
    ..To determine the prevalence of obstructive sleep apnoea (OSA) in adult patients with drug-resistant hypertension, a common problem in a tertiary care facility...
  83. ncbi Snoring in preschool children: prevalence, severity and risk factors
    C E Kuehni
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    Eur Respir J 31:326-33. 2008
    ..The strong association with atopic disorders, viral infections and environmental exposures suggests a complex aetiology, based on a general vulnerability of the respiratory tract...
  84. ncbi Con: Sleep apnea does not cause cardiovascular disease
    John Stradling
    Am J Respir Crit Care Med 169:148-9; discussion 150. 2004
  85. ncbi The nose and sleep-disordered breathing: what we know and what we do not know
    Maria Rappai
    Division of Pulmonary Critical Care Medicine, University of Mississippi Medical Center, Jackson, MS, USA
    Chest 124:2309-23. 2003
    ..We postulate that the switch to oronasal breathing that occurs with chronic nasal conditions is a final common pathway for SDB...
  86. ncbi Bi-level positive pressure ventilation and adaptive servo ventilation in patients with heart failure and Cheyne-Stokes respiration
    Ingo Fietze
    Charite Universitatsmedizin Berlin, CCM, Department of Internal Medicine, Center for Sleep Medicine, Luisenstr 13, D 10117 Berlin, Germany
    Sleep Med 9:652-9. 2008
    ..We investigated the effect of a bi-level PPV and adaptive servo ventilation on LVEF, CSR, and quantitative sleep quality...
  87. ncbi Sleep-disordered breathing: a risk factor for adverse pregnancy outcomes?
    Francesca L Facco
    Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois, USA
    Am J Perinatol 29:277-82. 2012
    ..7%. SDB, especially moderate to severe disease, may be associated with APO. However, it is unclear if SDB is a risk factor for APO independent of obesity...
  88. ncbi Sleep-disordered breathing in obese children: the southern Italy experience
    Luigia Brunetti
    Clinica Pediatrica S Maggiore, Policlinico, University of Bari, Piazza Giulio Cesare, 11 70124 Bari, Italy
    Chest 137:1085-90. 2010
    ..We sought an association between sleep-disordered breathing (SDB) and overweight and/or obesity in a large cohort of school- and preschool-aged children in Southern Italy...
  89. ncbi A simple method to identify sleep apnea using Holter recordings
    Phyllis K Stein
    Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri 63108, USA
    J Cardiovasc Electrophysiol 14:467-73. 2003
    ....
  90. ncbi Long-term nasal continuous positive airway pressure administration can normalize hypertension in obstructive sleep apnea patients
    M Suzuki
    Stanford University Sleep Disorders Clinic and Research Center, California 94304
    Sleep 16:545-9. 1993
    ..Average HR during the day and at night decreased significantly from 85.2 bpm to 72.6 bpm and from 69.8 bpm to 56.5 bpm in the hypertensives (p = 0.04), but not in normotensives.(ABSTRACT TRUNCATED AT 250 WORDS)..
  91. ncbi The prevalence of sleepiness and the risk of sleep-disordered breathing in children with positive allergy test
    Stacey L Ishman
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Int Forum Allergy Rhinol 2:139-43. 2012
    ..We evaluated the prevalence of sleep-disordered breathing (SDB) and sleepiness in children with allergy and compared sleep-specific quality of life measures to those of children without allergy...
  92. pmc Reactive oxygen species and the brain in sleep apnea
    Yang Wang
    Section of Pediatric Sleep Medicine, Department of Pediatrics, Comer Children s Hospital, The University of Chicago, Chicago, IL 60637, USA
    Respir Physiol Neurobiol 174:307-16. 2010
    ..The initial evidence for NADPH oxidase and mitochondrial involvement in IH-induced ROS production and neuronal injury unquestionably warrants future research efforts...
  93. ncbi Cross-correlation of EEG frequency bands and heart rate variability for sleep apnoea classification
    Haslaile Abdullah
    School of Electrical and Computer Engineering, Science, Engineering and Health, RMIT University, 376 392 Swanston Street, GPO Box 2476V, Melbourne, Vic, 3001, Australia
    Med Biol Eng Comput 48:1261-9. 2010
    ..When delta and acceleration coefficients of the EEG features were incorporated, then the overall accuracy improved to 71%...
  94. ncbi Familial risk of sleep-disordered breathing
    Karin Lundkvist
    Department of Otorhinolaryngology, Karolinska Institutet, Stockholm, Sweden
    Sleep Med 13:668-73. 2012
    ....
  95. ncbi New tracheal sound feature for apnoea analysis
    A Kulkas
    Department of Clinical Neurophysiology, Medical Imaging Center, Pirkanmaa Hospital District, Tampere, Finland
    Med Biol Eng Comput 47:405-12. 2009
    ..8%. Due to the individual differences in tracheal sound signal amplitudes, developing amplitude-independent means for screening apnoea events is beneficial...
  96. ncbi Reliability and validity studies of the Turkish version of the Epworth Sleepiness Scale
    Bilgay Izci
    Department of Sleep Medicine, University of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, Scotland, UK
    Sleep Breath 12:161-8. 2008
    ..The ESStr is a reliable and valid measure of daytime sleepiness. These features and the simplicity of the ESStr make it a valuable measure for clinical management and research...
  97. ncbi Automatic breath-to-breath analysis of nocturnal polysomnographic recordings
    P J van Houdt
    Department of Research and Development, Kempenhaeghe, Postbus 61, 5590 AB, Heeze, The Netherlands
    Med Biol Eng Comput 49:819-30. 2011
    ....
  98. ncbi Children's sleep and adjustment over time: the role of socioeconomic context
    Mona El-Sheikh
    Human Development and Family Studies, 203Spidle Hall, Auburn University, Auburn, AL 36849 5214, USA
    Child Dev 81:870-83. 2010
    ..Findings highlight the importance of adequate sleep for children's optimal development, especially in the context of ecological risk...
  99. ncbi Neurobehavioral manifestations in obstructive sleep apnea syndrome before and after treatment with continuous positive airway pressure
    J Montplaisir
    , , , Canada
    Sleep 15:S17-9. 1992
    ..After treatment, hypoxemia-related deficits and some degree of sleepiness persist. These results raise the possibility of an irreversible anoxic central nervous system (CNS) damage in severe OSAS...
  100. ncbi High fat/refined carbohydrate diet enhances the susceptibility to spatial learning deficits in rats exposed to intermittent hypoxia
    A D Goldbart
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Brain Res 1090:190-6. 2006
    ..high fat refined carbohydrate diet (HF/RC) can induce similar deficits and associated changes in signaling pathways under normoxic conditions...
  101. pmc Impaired spatial working memory and altered choline acetyltransferase (CHAT) immunoreactivity and nicotinic receptor binding in rats exposed to intermittent hypoxia during sleep
    Barry W Row
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
    Behav Brain Res 177:308-14. 2007
    ..However, compensatory mechanisms may also be activated in other brain regions, and may provide potential therapeutic targets for the cognitive impairments associated with SDB...

Research Grants69

  1. Treatment of Sleep Apnea using a Positive Airway Pressure Rebreathing Modulator
    Matthew D Tarler; Fiscal Year: 2011
    ..of positive airway pressure therapies is an important stabilizing factor for chemoreflex-modulated sleep apnea syndromes. The Positive Airway Pressure Gas Modulator (PAPGAM), a new class of positive airway pressure device ..
  2. Stimulation Induced Modulation of Sleep
    MATTHEW TARLER; Fiscal Year: 2009
    ..chemoreflexes can contribute to the severity of sleep apnea, and the development of hypertension in sleep apnea syndromes. In congestive heart failure, augmented carotid chemoreflexes contributes to the increased sympathetic ..
  3. Effects of aging on sleep architecture
    Naresh Punjabi; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  4. EARLY IDENTIFICATION AND TREATMENT OF SLEEP APNEA
    Naresh Punjabi; Fiscal Year: 2003
    ..Punjabi the opportunity to reach his full potential as a clinical investigator. ..
  5. THE SLEEP HEART HEALTH STUDY
    Naresh Punjabi; Fiscal Year: 2007
    ..Accomplishing these goals will provide important information concerning the public health impact of SDB. ..
  6. Longtitudinal Changes in Sleep Structure: Implications for Health Outcomes
    Naresh Punjabi; Fiscal Year: 2010
    ....
  7. WORKING MEMORY IN OBSTRUCTIVE SLEEP APNEA-AN fMRI STUDY
    Robert Thomas; Fiscal Year: 2006
    ..abstract_text> ..
  8. ECG-derived estimators of sleep physiology
    Robert Thomas; Fiscal Year: 2006
    ..3) To correlate the biomarker with excessive daytime sleepiness, subjective sleep quality and cardiovascular morbidity (SHHS), and reduced neurocognitive function (NAPS). ..
  9. THE ROLE OF CYTOKINES IN SLEEPINESS AND SLEEP APNEA
    Alexandros Vgontzas; Fiscal Year: 2009
    ..These studies collectively will provide additional evidence for a role of TNFa and IL-6 in EDS and OSA and lay the foundation for the development of novel therapeutic interventions. ..
  10. NEURAL CONTROL OF CARDIORESPIRATORY FUNCTION
    Ronald Harper; Fiscal Year: 2004
    ....
  11. Melatonin Randomized Trial in Insomnia in the Elderly
    Nalaka Gooneratne; Fiscal Year: 2006
    ..abstract_text> ..
  12. PHYSIOLOGICAL DEVELOPMENT IN SIDS
    Ronald Harper; Fiscal Year: 2009
    ..Since SIDS may result from hypotension or failure to enhance breathing to hypoxia, the studies may describe mechanisms of failure in the syndrome. ..
  13. ROLE OF MELATONIN IN SECONDARY INSOMNIA IN THE ELDERLY
    Nalaka Gooneratne; Fiscal Year: 2004
    ....
  14. Snoring, Early Behavior, and Oxidant Stress
    HAWLEY MONTGOMERY DOWNS; Fiscal Year: 2004
    ..In addition, it may provide insights into a potential mechanism for this morbidity. ..
  15. Biomarkers of Aging in the Bay Area Sleep Cohort
    Donald Bliwise; Fiscal Year: 2005
    ..abstract_text> ..
  16. Postpartum Sleep Deprivation and Fragmentation: Effects on Maternal Functioning
    HAWLEY MONTGOMERY DOWNS; Fiscal Year: 2008
    ..The study results will help researchers develop better strategies for improving the sleep of new mothers, and in turn improving their ability to function effectively. [unreadable] [unreadable] [unreadable]..
  17. Polysomnographic Assessment of Alternative Treatment
    Donald Bliwise; Fiscal Year: 2006
    ..abstract_text> ..
  18. Sleep/Wake Contiuum in Lewy Body Disease
    Donald L Bliwise; Fiscal Year: 2010
    ..The proposed work will also provide important clinical insights into disease correlates and disease course across the broad spectrum of Parkinsonism. ..
  19. SUNDOWN SYNDROME IN A SKILLED NURSING FACILITY
    Donald Bliwise; Fiscal Year: 2002
    ..These results will provide information on the mechanistic basis for sundowning in aged patients with dementing disorders. ..
  20. CAUSES OF SLEEP-INDUCED BREATHING INSTABILITIES
    Jerome Dempsey; Fiscal Year: 2002
    ..These latter studies conduced in sleep are important to testing the sensitivity of respiratory control mechanisms to mechanical feedback-a problem which remains relatively unexplored, especially in the human. ..
  21. Obstructive Sleep Apnea (OSA) in obese teens & preteens: Neurobahavioral effects
    Dean Beebe; Fiscal Year: 2008
    ..abstract_text> ..
  22. Family Linkage Study of Obstructive Sleep Apnea
    Allan Pack; Fiscal Year: 2007
    ..abstract_text> ..
  23. CASE CONTROL STUDY OF INSOMNIA IN NONDEPRESSED ELDERLY
    Allan Pack; Fiscal Year: 2001
    ....
  24. SDB, metabolic syndrome, and vascular function
    F Nieto; Fiscal Year: 2006
    ..abstract_text> ..
  25. Sleep and Functional Performance in Heart Failure
    Nancy Redeker; Fiscal Year: 2006
    ..SEM will be used to evaluate the factor structure of the sleep disturbance construct and serve as a tool to explore the direct and indirect pathways linking the major study variables. ..
  26. FATIGUE, SLEEP AND CIRCADIAN RHYTHMS IN BREAST CANCER
    Sonia Ancoli Israel; Fiscal Year: 2004
    ..Results will provide a scientific basis for future intervention studies, particularly studies with light therapy which can re-synchronize rhythms. ..
  27. Cognitive Behavioral Therapy for Insomnia in Stable Heart Failure
    Nancy S Redeker; Fiscal Year: 2010
    ..We plan to test the effects of cognitive behavioral therapy, on sleep, daytime symptoms, and function middle-aged and older adults who have heart failure. ..
  28. Contributions of sleep/rhythms/fatigue to "chemobrain"
    Sonia Ancoli Israel; Fiscal Year: 2009
    ..The reported phenomena of chemobrain will be examined to see if it is related to the complaint of fatigue or sleep disruptions, both of which are known to contribute to decreases in cognitive functioning. ..
  29. TREATMENT OF SLEEP APNEA IN THE ELDERLY
    Allan Pack; Fiscal Year: 2003
    ..These data will give novel definitive information both about identification and treatment of sleep apnea in the elderly. ..
  30. MICROARRAY EXPRESSION PROFILING OF RODENT MODELS OF HUMA
    Allan Pack; Fiscal Year: 2003
    ..abstract_text> ..
  31. Mechanisms of Sleep-Disordered Breathing in the Menopausal Transition
    Grace W Pien; Fiscal Year: 2010
    ..These findings will allow us to identify women at risk for sleep-disordered breathing after menopause and to focus on tailoring treatments in this area. ..
  32. Impact of intermittent hypoxia on ventilatory drive and apnea severity
    JASON HAROLD MATEIKA; Fiscal Year: 2010
    ..This treatment could be particularly useful in individuals who suffer from mild or moderate forms of OSA when used in conjunction with other potential innovative therapies. ..
  33. PREDOCTORAL TRAINING PROGRAM IN NEUROSCIENCE
    RALPH FREGOSI; Fiscal Year: 2008
    ..Facilities for research training include the extensive equipment and expertise in individual faculty laboratories, as well as comprehensive shared resources at the University of Arizona. ..
  34. Genetic Mechanisms for Central Apneas
    Kingman Strohl; Fiscal Year: 2007
    ..A genomic approach to recurrent central apneas might provide pathogenic insight relevant to primary sleep apnea syndromes and neurological conditions associated with recurrent apneas and unstable breathing...
  35. Vascular Functions in Children with Sleep Disorder Breathing
    Raouf S Amin; Fiscal Year: 2010
    ....
  36. Adolescent Self-Management of Diabetes: An Intervention
    Shelagh Mulvaney; Fiscal Year: 2007
    ..A larger study will allow for reliable estimates of efficacy for clinical outcomes such as HbA1c, and will allow subgroup analyses with ethnicity, gender, and SES. [unreadable] [unreadable] [unreadable]..
  37. Sleep-Health & Knowledge in U.S. Hispanics
    JOSE LOREDO; Fiscal Year: 2009
    ..S. Mexican-American Hispanics should include intensive focus on Sleep Health and Sleep Health knowledge deficits. Key Words: Sleep disorders;Minority health;Epidemiology. ..
  38. The Sleep Heart Health Study (SHHS)
    STUART QUAN; Fiscal Year: 2007
    ..Accomplishing these goals will provide important information concerning the public health impact of SDB. [unreadable] [unreadable]..
  39. Technological Home Care: Improving Caregiving
    Carol Smith; Fiscal Year: 2009
    ..The potential significance and the long term goals are to strengthen home caregiving skills, improve health status, quality of life and self-management of chronic illness symptoms and invasive home care treatment. ..
  40. Consequences of Neonatal Hypoxia
    Nanduri Prabhakar; Fiscal Year: 2009
    ..Understanding the consequences of neonatal IH provide insights into how neonatal intermittent hypoxia caused by recurrent apneas affects the ventilation in premature infants. Experimental Animal Model: Rat Pups. ..
  41. Cardiovascular Disease (C/V) in Children with Obstructive Sleep Apnea (OSA)
    Raouf Amin; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  42. Intertrigeminal region control of apnea
    Miodrag Radulovacki; Fiscal Year: 2007
    ..abstract_text> ..
  43. P20-Mediated Suppression of Vascular Force
    Christopher Rembold; Fiscal Year: 2004
    ..Many current treatments target smooth muscle to reduce tone. It is possible that targeting the force suppression pathway (i.e. p20) might provide comparable benefits. ..
  44. NO-CGMP INHIBITION OF UROGENITAL SMOOTH MUSCLE
    Christopher Rembold; Fiscal Year: 2004
    ....
  45. CHEMORECEPTORS AND HYPERTENSION AND SLEEP APNEA
    JOSE LOREDO; Fiscal Year: 2003
    ..This training will provide the basis of an MPH degree and a solid theoretical background for future conduct of quality clinical research. ..
  46. GENE REGULATION DURING INTERMITTENT HYPOXIA
    Nanduri Prabhakar; Fiscal Year: 2003
    ....
  47. PUPILLOMETRIC SLEEPINESS IN TREATED SLEEP DISORDERS
    Joan Shaver; Fiscal Year: 2003
    ..Results will provide evidence about the PUI as a reliable and valid objective outcome measure of waking tendency among controls, and pre-post-treatment for OSA and narcolepsy subjects. ..
  48. NEUROMUSCULAR CONTROL OF THE PHARYNGEAL AIRWAY
    RALPH FREGOSI; Fiscal Year: 2002
    ..These experiments will lay the foundation for new and improved treatment strategies for persons with obstructive sleep apnea or with other conditions that are caused by malfunction of the tongue motor system. ..
  49. SLEEP AND ENTERTAIMENT OF SCN FUNCTION
    Kingman Strohl; Fiscal Year: 2002
    ..abstract_text> ..
  50. MN REGIONAL SLEEP DISORDERS CENTER SLEEP ACADEMIC AWARD
    Gerald Rosen; Fiscal Year: 2002
    ....
  51. SLEEP ACADEMIC AWARD--RECOGNITION OF SLEEP DISORDERS
    Kingman Strohl; Fiscal Year: 2002
    ..We will disseminate of educational assessments, patient-oriented material, and clinical pathways through local and national consultants in both the public and private sector, as well as through interaction with other awardees. ..
  52. GENETIC DISSECTION OF VENTILATORY TRAITS
    Kingman Strohl; Fiscal Year: 2001
    ..Results will be relevant to illnesses known to result from, or be exacerbated by, poor or excessive ventilatory responses to environmental and pathophysiologic stresses. ..
  53. RURAL DWELLING OLDER ADULTS: CPAP ADHERENCE SUPPORT
    Carol Smith; Fiscal Year: 2004
    ..abstract_text> ..
  54. A Wireless, Multi-Channel Telemetric Biosensor for Research in Animal Models
    Kingman Strohl; Fiscal Year: 2006
    ..The proposed research will facilitate animal studies that may lead to a better understanding of sleep disorders and potentially new interventions. [unreadable] [unreadable] [unreadable]..
  55. HEART RATE VARIABILITY IN SLEEP-DISORDERED BREATHING
    MICHAEL KHOO; Fiscal Year: 2005
    ....
  56. Longitudinal Study--Sleep-Disordered Breathing/Pregnancy
    Grace Pien; Fiscal Year: 2006
    ....
  57. MENOPAUSE AND MIDLIFE AGING EFFECTS ON SLEEP DISORDERS
    Terry Young; Fiscal Year: 2006
    ....
  58. PREVALENCE OF SLEEP DISORDERED BREATHING IN CHILDREN
    Edward Bixler; Fiscal Year: 2005
    ..The parents of this group will be interviewed for the family history of risk factors associated with SDB in children. This strategy will yield adequate power to establish the prevalence and clinical significance of SDB in children. ..
  59. PERIPHERAL CHEMORECEPTORS: MECHANISMS & MODULATIONS
    Sukhamay Lahiri; Fiscal Year: 2003
    ..The aim of this proposal is to understand how the processes are initiated in the chemosensory cells. ..
  60. Nicotine induced neuroplasticity in the carotid body
    Estelle Gauda; Fiscal Year: 2004
    ....
  61. SLEEP HEART HEALTH STUDY
    GEORGE O CONNOR; Fiscal Year: 2007
    ..Accomplishing these goals will provide important information concerning the public health impact of SDB. ..
  62. Sleep and Nocturnal Endocrine Function in MDMA User
    Una McCann; Fiscal Year: 2007
    ..Results from the proposed studies will help better define the functional consequences of MDMA exposure in humans, and could shed light on the roles of 5-HT and DA in sleep and nocturnal endocrine function. ..
  63. Impact of CPAP on Functional Outcomes in Milder OSA
    Terri Weaver; Fiscal Year: 2006
    ..Secondary aims of the study are: 1) to examine whether CPAP also improves daytime sleepiness; 2) to determine whether CPAP can reduce nocturnal blood pressure to lower the risk for stroke and hypertension linked to OSA. ..
  64. Exploration of ETS Effects on Child Behavior and Sleep
    Kimberly Yolton; Fiscal Year: 2005
    ..abstract_text> ..
  65. MCI, APOE and Sleep Apnea: Effects on Cognition
    RUTH O HARA; Fiscal Year: 2009
    ..Reducing cognitive impairment and delaying the onset of AD has significant clinical and economic benefits. Thus, the answer to this question could significantly enhance our therapeutic approach to cognitive impairment in older adults. ..