- Swimming-induced pulmonary edema in triathletes
Charles C Miller
Department of Biomedical Sciences, Texas Tech University Health Sciences Center at El Paso Paul L Foster School of Medicine, El Paso, TX 79905, USA
Am J Emerg Med 28:941-6. 2010
b>Pulmonary edema related to water immersion has been reported in military trainees and scuba and breath-hold divers, but rarely in the community. To date, no risk factors for this phenomenon have been identified by epidemiological methods...
- Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles of cytokines and cellular immune activation in patients with pulmonary edema
Shih Min Wang
Department of Emergency Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
J Infect Dis 188:564-70. 2003
..epidemics of enterovirus 71 (EV71) infections, which were associated with brainstem encephalitis (BE) and pulmonary edema (PE)...
- Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management
Michael A Matthay
Department of Medicine, Cardiovascular Research and Training Institute, University of California at San Francisco, San Francisco, California 94143 0130, USA
Am J Respir Cell Mol Biol 33:319-27. 2005
- Update on high-altitude pulmonary edema: pathogenesis, prevention, and treatment
Joshua O Stream
Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA
Wilderness Environ Med 19:293-303. 2008
High-altitude pulmonary edema (HAPE) is a life-threatening noncardiogenic form of pulmonary edema (PE) that afflicts susceptible persons after rapid ascent to high altitude above 2500 m...
- Protein kinase C modulates pulmonary endothelial permeability: a paradigm for acute lung injury
Research Service, Stratton Veterans Affairs Medical Center and the Center for Cardiovascular Science, The Albany Medical College, Albany, New York 12208, USA
Am J Physiol Lung Cell Mol Physiol 284:L435-51. 2003
The intracellular serine/threonine kinase protein kinase C (PKC) has an important role in the genesis of pulmonary edema. This review discusses the PKC-mediated mechanisms that participate in the pulmonary endothelial response to agents ..
- Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema
Carole A Oskeritzian
Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
J Exp Med 207:465-74. 2010
..E-triggered anaphylactic responses, including elevation of circulating histamine and associated pulmonary edema in mice, were significantly attenuated by the S1P(2) antagonist JTE-013 and in S1P(2)-deficient mice, in ..
- Lung overexpression of the vascular endothelial growth factor gene induces pulmonary edema
R J Kaner
Division of Pulmonary and Critical Care Medicine and Weill Medical College of Cornell University, New York, New York, USA
Am J Respir Cell Mol Biol 22:657-64. 2000
..an identical adenovirus vector with an irrelevant transgene had no effect upon subsequent AdVEGF165-induced pulmonary edema. Together, these data suggest that overexpression of VEGF in the lung may be one mechanism of increased ..
- Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells
Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
Circ Res 103:1164-72. 2008
..In contrast to wild-type mice, Sphk1(-/-) mice showed markedly enhanced pulmonary edema formation in response to lipopolysaccharide and PAR-1 activation...
- Extravascular lung water indexed to predicted body weight is a novel predictor of intensive care unit mortality in patients with acute lung injury
Thelma R Craig
Regional Intensive Care Unit, Royal Victoria Hospital, Belfast, UK
Crit Care Med 38:114-20. 2010
Acute lung injury and the acute respiratory distress syndrome are characterized by noncardiogenic pulmonary edema, which can be assessed by measurement of extravascular lung water...
- Prevention and treatment of high-altitude pulmonary edema
Intensive Care Unit, Department of Internal Medicine, University Hospital, Ramistrasse 100, CH 8091 Zurich, Switzerland
Prog Cardiovasc Dis 52:500-6. 2010
..altitude illness, a cerebral form called acute mountain sickness and a pulmonary form called high-altitude pulmonary edema (HAPE). Individual susceptibility is the most important determinant for the occurrence of HAPE...
- Sodium tanshinone iia sulfonate attenuates seawater aspiration-induced acute pulmonary edema by up-regulating Na(+),K(+)-ATPase activity
Xiao Yan Xie
Department of Respiratory Medicine, Tangdu Hospital, Fourth Military Medical University, Xi an, Shaanxi, PR China
Exp Lung Res 37:482-91. 2011
Relieving pulmonary edema is the key of a successful treatment to seawater drowning. Sodium tanshinone IIA sulfonate (STS) has been observed to reduce lung edema from lipopolysaccharide (LPS)-induced lung injury...
- Non-invasive pressure support ventilation versus conventional oxygen therapy in acute cardiogenic pulmonary oedema: a randomised trial
Cardiology Department, Consorci Sanitari Creu Roja de Catalunya, Hospital Creu Roja de Barcelona, University of Barcelona, Spain
Lancet 356:2126-32. 2000
..We assessed the efficacy of this therapy in acute cardiogenic pulmonary oedema in a randomised comparison with conventional oxygen therapy...
- Anti-asthmatic agents alleviate pulmonary edema by upregulating AQP1 and AQP5 expression in the lungs of mice with OVA-induced asthma
Department of Pulmonary Medicine, Research Institute of Respiratory Disease, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Respir Physiol Neurobiol 181:21-8. 2012
..Dexamethasone and ambroxol improved the eosinophil infiltration, mucus secretion, and pulmonary edema caused by OVA, but terbutaline only alleviated pulmonary edema...
- Caspase-1 inhibitor prevents neurogenic pulmonary edema after subarachnoid hemorrhage in mice
Stroke 40:3872-5. 2009
We examined the effects of a caspase-1 inhibitor, N-Ac-Tyr-Val-Ala-Asp-chloromethyl ketone (Ac-YVAD-CMK), on neurogenic pulmonary edema in the endovascular perforation model of subarachnoid hemorrhage (SAH) in mice.
- Lung edema clearance: 20 years of progress: invited review: role of aquaporin water channels in fluid transport in lung and airways
Will Rogers Institute Pulmonary Research Center, Department of Medicine, University of Southern California, Los Angeles 90033 3721, USA
J Appl Physiol 93:2199-206. 2002
..However, the possibility remains that AQPs may play a role in lung physiology under conditions of stress and/or injury not yet tested or in functions unrelated to transepithelial fluid transport...
- Barrier enhancing signals in pulmonary edema
Konstantin G Birukov
Lung Injury Center, Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, Illinois, USA
Compr Physiol 3:429-84. 2013
..permeability and reduction of alveolar liquid clearance capacity are two leading pathogenic mechanisms of pulmonary edema, which is a major complication of acute lung injury, severe pneumonia, and acute respiratory distress ..
- High-altitude pulmonary edema
Norbert F Voelkel
University of Colorado Health Sciences Center, Denver, CO 80262, USA
N Engl J Med 346:1606-7. 2002
- Predictors of the first heart failure hospitalization in patients who are stable survivors of myocardial infarction complicated by pulmonary congestion and/or left ventricular dysfunction: a VALIANT study
Eldrin F Lewis
Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Eur Heart J 29:748-56. 2008
..We sought to assess the incidence of and prognostic factors for heart failure (HF) hospitalization among survivors of high-risk acute myocardial infarction (MI)...
- Saturated hydrogen saline protects the lung against oxygen toxicity
Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China
Undersea Hyperb Med 37:185-92. 2010
..These results demonstrated that saturated hydrogen saline alleviated hyperoxia-induced pulmonary injury, which was partly responsible for the inhibition of oxidative damage...
- The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome
Department of Internal Medicine, University Hospital of Geneva, Switzerland
Crit Care Med 27:304-12. 1999
..the concentrations of proinflammatory mediators, collagenases, and procollagen type III peptides in undiluted pulmonary edema fluids and in plasma obtained in patients with early acute respiratory distress syndrome (ARDS) and in ..
- Modulation of cytokine production by intravenous immunoglobulin in patients with enterovirus 71-associated brainstem encephalitis
Shih Min Wang
Department of Emergency Medicine, National Cheng Kung University and Hospital, 138 Sheng Li Road, 70428 Tainan, Taiwan
J Clin Virol 37:47-52. 2006
..Several epidemics of enterovirus 71 (EV71) infections occurred in Taiwan since 1998...
- Pathogenesis of high-altitude pulmonary edema: inflammation is not an etiologic factor
Erik R Swenson
Pulmonary and Critical Care Section, S 111 Pulm, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
JAMA 287:2228-35. 2002
The pathogenesis of high-altitude pulmonary edema (HAPE) is considered an altered permeability of the alveolar-capillary barrier secondary to intense pulmonary vasoconstriction and high capillary pressure, but previous bronchoalveolar ..
- Synergistic effect of the genetic polymorphisms of the renin-angiotensin-aldosterone system on high-altitude pulmonary edema: a study from Qinghai-Tibet altitude
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences Peking Union Medical College, No 5 Dong Dan San Tiao, Beijing 100005, China
Eur J Epidemiol 23:143-52. 2008
The pathogenesis of high-altitude pulmonary edema (HAPE) has been at least partially attributed to the local dysregulation of the renin-angiotensin-aldosterone system (RAAS) cascade...
- Physiological aspects of high-altitude pulmonary edema
Department of Internal Medicine VII, Division of Sports Medicine, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
J Appl Physiol (1985) 98:1101-10. 2005
High-altitude pulmonary edema (HAPE) develops in rapidly ascending nonacclimatized healthy individuals at altitudes above 3,000 m...
- Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN
Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030 3501, USA
Arterioscler Thromb Vasc Biol 27:1312-8. 2007
..However, cellular consequences of S1P2R signaling in the vascular cells are not well understood...
- Emerging themes of cAMP regulation of the pulmonary endothelial barrier
Sarah L Sayner
Dept of Cell Biology and Neuroscience, Member, Center for Lung Biology, College of Medicine, Univ of South Alabama, Mobile, AL 36688, USA
Am J Physiol Lung Cell Mol Physiol 300:L667-78. 2011
- Pathophysiology of acute lung injury and the acute respiratory distress syndrome
Lorraine B Ware
Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Semin Respir Crit Care Med 27:337-49. 2006
..Future therapies aimed at restoring the overall balance of cytokines, oxidants, coagulants, and proteases may ultimately be successful where therapies that target individual cytokines or other mediators have not...
- Hypoxia impairs systemic endothelial function in individuals prone to high-altitude pulmonary edema
Marc M Berger
Department of Internal Medicine VI Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Germany
Am J Respir Crit Care Med 172:763-7. 2005
High-altitude pulmonary edema (HAPE) is characterized by excessive pulmonary vasoconstriction and is associated with decreased concentrations of nitric oxide (NO) in the lung...
- Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung
Jae W Lee
Department of Anesthesiology, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 106:16357-62. 2009
..coli endotoxin. Intra-bronchial instillation of endotoxin into the distal airspaces resulted in pulmonary edema with the loss of alveolar epithelial fluid transport measured as alveolar fluid clearance...
- Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury
Daniel F McAuley
Cardiovascular Research Institute, University of California, San Francisco, CA, USA
Crit Care Med 32:1470-6. 2004
..clinically relevant airspace concentrations of beta2-adrenergic agonists stimulated maximal alveolar fluid clearance rates and to determine whether beta2 agonist therapy decreased pulmonary edema in experimental acute lung injury.
- Deaths in children during an outbreak of hand, foot and mouth disease in Peninsular Malaysia--clinical and pathological characteristics
University of Malaya, Kuala Lumpur
Med J Malaysia 60:297-304. 2005
- New insights in the pathogenesis of high-altitude pulmonary edema
Department of Internal Medicine and the Botnar Center for Extreme Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Prog Cardiovasc Dis 52:485-92. 2010
High-altitude pulmonary edema is a life-threatening condition occurring in predisposed but otherwise healthy individuals...
- Usefulness of ultrasound lung comets as a nonradiologic sign of extravascular lung water
Institute of Clinical Physiology, CNR Lab, Via Moruzzi 1, 56123 Pisa, Italy
Am J Cardiol 93:1265-70. 2004
- Noninvasive ventilation in acute cardiogenic pulmonary edema: a meta-analysis of randomized controlled trials
Grupo de Estudio, Docencia e Investigación Clínica, Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
J Card Fail 17:850-9. 2011
The evidence of individual studies in acute cardiogenic pulmonary edema (ACPE) supporting noninvasive ventilation (NIV) is still inconclusive, particularly regarding noninvasive positive pressure ventilation (NIPPV).
- Reexpansion pulmonary edema
Department of Surgery, Faculty of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
Ann Thorac Cardiovasc Surg 14:205-9. 2008
When a rapidly reexpanding lung has been in a state of collapse for more than several days, pulmonary edema sometimes occurs in it. This is called reexpansion pulmonary edema (RPE)...
- Functional identification of the alveolar edema reabsorption activity of murine tumor necrosis factor-alpha
Division of Anesthesiological Investigations, University Medical Center, Geneva, Switzerland
Am J Respir Crit Care Med 168:1043-50. 2003
..There was also a significant reduction in lung water. These results indicate that the receptor-independent lectin-like domain of mTNF-alpha has a potential physiological role in the resolution of alveolar edema in rats and mice...
- Secular trends in nosocomial infections and mortality associated with noninvasive ventilation in patients with exacerbation of COPD and pulmonary edema
Unité d Hygiène et Prévention de l Infection, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, Creteil, France
JAMA 290:2985-91. 2003
..But whether these benefits translate to a clinical setting is unclear...
- Serial measurement of extravascular lung water and blood volume during the course of neurogenic pulmonary edema after subarachnoid hemorrhage: initial experience with 3 cases
Department of Surgical Neurology, Research Institute for Brain and Blood Vessels, Akita, Japan
J Neurosurg Anesthesiol 24:203-8. 2012
Neurogenic pulmonary edema (NPE) as a systemic consequence early after aneurysmal subarachnoid hemorrhage (SAH) sometimes complicates perioperative and postoperative fluid management and increases the risk of a poor outcome...
- High altitude pulmonary edema: a pressure-induced leak
Medical University Clinic, Department of Internal Medicine, Div of Sports Medicine, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
Respir Physiol Neurobiol 158:266-73. 2007
High altitude pulmonary edema (HAPE) is a non-cardiogenic pulmonary edema that can occur in healthy individuals who ascend rapidly to altitudes above 3000-4000m...
- Acute pulmonary edema in pregnancy
Anthony C Sciscione
Department of Obstetrics and Gynecology, Maternal Fetal Medicine Division, Christiana Care Health Services, 4755 Ogletown Stanton Road, Newark, DE 19718, USA
Obstet Gynecol 101:511-5. 2003
To describe the incidence, predisposing conditions, and inciting factors culminating in pulmonary edema in the pregnant patient.
- Boussignac continuous positive airway pressure device in the emergency care of acute cardiogenic pulmonary oedema: a randomized pilot study
Emergency Department, CHU de Rouen, Hopital Charles Nicolle, 1 rue de Germont, 76031 Rouen Cedex, France
Eur J Emerg Med 10:204-8. 2003
..It can quickly improve respiratory distress in acute cardiogenic pulmonary oedema patients. A larger trial should be initiated in such an emergency care setting to demonstrate the effectiveness of the Boussignac-CPAP device...
- N-acetylcysteine prevents pulmonary edema and acute kidney injury in rats with sepsis submitted to mechanical ventilation
Laboratory for Medical Research, Nephrology Department, University of SãoPaulo School of Medicine, Sao Paulo, Brazil
Am J Physiol Lung Cell Mol Physiol 302:L640-50. 2012
..The protective effects of NAC (against kidney and lung injury) are likely attributable to the decrease in oxidative stress, suggesting that NAC can be useful in the treatment of sepsis...
- Microarray analysis indicates that pulmonary edema fluid from patients with acute lung injury mediates inflammation, mitogen gene expression, and fibroblast proliferation through bioactive interleukin-1
Mitchell A Olman
Department of Medicine, Division of Pulmonary and Critical Care Medicine, The University of Alabama, Birmingham, AL 35294, USA
Chest 121:69S-70S. 2002
- Randomised controlled comparison of continuous positive airways pressure, bilevel non-invasive ventilation, and standard treatment in emergency department patients with acute cardiogenic pulmonary oedema
S D Crane
Department of Emergency Medicine, Leeds General Infirmary, UK
Emerg Med J 21:155-61. 2004
..The efficacy of both treatments was assessed in the UK emergency department setting, in a randomised comparison with standard oxygen therapy...
- The lectin-like domain of tumor necrosis factor-alpha improves alveolar fluid balance in injured isolated rabbit lungs
University of Giessen Lung Center, Giessen, Germany
Crit Care Med 36:1543-50. 2008
Identification of mechanisms that preserve optimal alveolar fluid balance during pulmonary edema is of great clinical importance...
- Randomized, prospective trial of oxygen, continuous positive airway pressure, and bilevel positive airway pressure by face mask in acute cardiogenic pulmonary edema
Division of Emergency Medicine, Heart Institute InCor, Hospital das Clinicas, University of Sao Paulo, Brazil
Crit Care Med 32:2407-15. 2004
To compare the effects of oxygen, continuous positive airway pressure (CPAP), and bilevel positive airway pressure (bilevel-PAP) on the rate of endotracheal intubation in patients with acute cardiogenic pulmonary edema.
- Doxycycline induces membrane expression of VE-cadherin on endothelial cells and prevents vascular hyperpermeability
Vascular Biology Program, Children s Hospital Boston, Department of Surgery, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
FASEB J 22:3728-35. 2008
..g., inflammatory and hypersensitivity disorders, pulmonary edema, traumatic lung injury, cerebral edema resulting from stroke, and others), it is important to develop ..
- Alveolar epithelial fluid transport in acute lung injury: new insights
Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143 0130, USA
Eur Respir J 20:1299-313. 2002
..Very recent data suggest that mechanisms that augment transepithelial sodium transport and enhance the clearance of alveolar oedema may lead to more effective prevention or treatment for some types of pulmonary oedema...
- Role of oxidative stress and NFkB in hypoxia-induced pulmonary edema
Department of Experimental Biology, Defense Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi 54, India
Exp Biol Med (Maywood) 233:1088-98. 2008
..increased oxidative stress further upregulates the nuclear transcription factor (NFkB) in the development of pulmonary edema. The rats were exposed to hypobaric hypoxia at 7620 m (280 mm Hg) for different durations, that is, 3 hrs, 6 ..
- Myocardial infarction rate in acute pulmonary edema: noninvasive pressure support ventilation versus continuous positive airway pressure
Emergency Department, Niguarda Ca Granda Hospital, P za Ospedale, Milano, Italy
Crit Care Med 32:1860-5. 2004
..support ventilation (NIPSV) delivered by face mask has proved an effective treatment for patients with acute pulmonary edema. However, an increase in acute myocardial infarction rate has been reported with this ventilation modality...
- Milrinone therapy for enterovirus 71-induced pulmonary edema and/or neurogenic shock in children: a randomized controlled trial
Chia Yu Chi
National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli County, Taiwan
Crit Care Med 41:1754-60. 2013
Enterovirus 71-induced brainstem encephalitis with pulmonary edema and/or neurogenic shock (stage 3B) is associated with rapid mortality in children...
- Simvastatin regulates CXC chemokine formation in streptococcal M1 protein-induced neutrophil infiltration in the lung
Department of Clinical Sciences, Section for Surgery, Malmo University Hospital, Lund University, Sweden
Am J Physiol Lung Cell Mol Physiol 300:L930-9. 2011
..Thus, simvastatin may be a useful tool to ameliorate acute lung injury in streptococcal infections...
- Identification of haptoglobin and apolipoprotein A-I as biomarkers for high altitude pulmonary edema
Peptide and Proteomics Division, Defence Institute of Physiology and Allied Sciences, Defence Research and Development Organization, Ministry of Defence, Delhi, India
Funct Integr Genomics 11:407-17. 2011
..and matrix-assisted laser desorption/ionization tandem time of flight from patients with high altitude pulmonary edema (HAPE)...
- Circulatory characteristics of normovolemia and normotension therapy after subarachnoid hemorrhage, focusing on pulmonary edema
Department of Neurosurgery, Tokyo Medical and Dental University, Yushima, Bunkyo ku, Japan
Acta Neurochir (Wien) 154:2195-202. 2012
Cardiopulmonary complications are common after subarachnoid hemorrhage (SAH), and include pulmonary edema (PE)...
- Streptococcal M1 protein-provoked CXC chemokine formation, neutrophil recruitment and lung damage are regulated by Rho-kinase signaling
Department of Clinical Sciences, Section for Surgery, Malmo University Hospital, Lund University, Malmo, Sweden
J Innate Immun 4:399-408. 2012
- Postobstructive pulmonary edema: a case for hydrostatic mechanisms
Richard D Fremont
Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, T1218 MCN, 1161 Twenty First Ave S, Nashville, TN 37232 2650, USA
Chest 131:1742-6. 2007
Postobstructive pulmonary edema is a well-recognized complication of upper airway obstruction...
- Neurogenic pulmonary edema in a fatal case of subarachnoid hemorrhage
Department of Anesthesiology, Hannover Medical School, D 30625 Hannover, Germany
J Clin Anesth 20:129-32. 2008
Neurogenic pulmonary edema (NPE) is caused by a variety of central nervous system lesions and may appear as a subclinical complication. The fulminant form of NPE is always life-threatening...
- Hypoxic preconditioning with cobalt ameliorates hypobaric hypoxia induced pulmonary edema in rat
Defence Institute of Physiology and Allied Sciences DIPAS, Lucknow Road, Timarpur, Delhi 110054, India
Eur J Pharmacol 656:101-9. 2011
..considered as an acute physiological stress and often leads to high altitude maladies such as high altitude pulmonary edema (HAPE) and high altitude cerebral edema (HACE)...
- Negative pressure pulmonary edema after oral and maxillofacial surgery
Department of Dental Anesthesiology, Tokyo Dental College, Chiba, Japan
Anesth Prog 56:49-52. 2009
Negative pressure pulmonary edema (NPPE) following upper airway obstruction (UAO) has been reported in several clinical situations. The main cause of NPPE is reported to be increased negative intrathoracic pressure...
- Assessment of acute pulmonary edema in dogs by electrical impedance imaging
J C Newell
Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Ttoy, NY 12180, USA
IEEE Trans Biomed Eng 43:133-8. 1996
Acute pulmonary edema was assessed quantitatively in 12 experiments on six anesthetized dogs. Thirty-two copper foil electrodes were placed around each animal's thorax at the level of the third intercostal space...
- Cardiac output increases prior to development of pulmonary edema after re-expansion of spontaneous pneumothorax
H C Tan
Division of Cardiology, Changi General Hospital, Singapore
Respir Med 96:461-5. 2002
b>Pulmonary edema following reexpansion of spontaneous pneumothorax is an uncommon complication. The underlying mechanism of this condition is unclear...
- Exercise-induced pulmonary edema in heart failure
Centro Cardiologico Monzino, IRCCS, Istituto di Cardiologia, Universita di Milano, Via Parea 4, 20138 Milan, Italy
Circulation 108:2666-71. 2003
..failure (HF) patients, exercise may increase pulmonary capillary hydrostatic pressure and thereby generate pulmonary edema. If pulmonary edema developed, alveolar-capillary membrane conductance (Dm), measured immediately after ..
- Boussignac continuous positive airway pressure for the management of acute cardiogenic pulmonary edema: prospective study with a retrospective control group
Thoraxcenter, Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1 P O Box 30, 001, 9700 RB Groningen, The Netherlands
BMC Cardiovasc Disord 7:40. 2007
Continuous positive airway pressure (CPAP) treatment for acute cardiogenic pulmonary edema can have important benefits in acute cardiac care...
- Chest sonography: a useful tool to differentiate acute cardiogenic pulmonary edema from acute respiratory distress syndrome
Emergency Department S, Antonio Abate General Hospital, Tolmezzo, Italy
Cardiovasc Ultrasound 6:16. 2008
Differential diagnosis between acute cardiogenic pulmonary edema (APE) and acute lung injury/acute respiratory distress syndrome (ALI/ARDS) may often be difficult...
- Negative pressure pulmonary edema--five case reports
Department of Anaesthesia and Intensive Care, Jordan University Hospital, Amman, Jordan
Middle East J Anesthesiol 18:977-84. 2006
- Neurogenic pulmonary edema during intracranial endovascular therapy
Randall P Brewer
Department of Anesthesiology, Duke University School of Medicine, Durham, NC, USA
Neurocrit Care 1:423-7. 2004
Neurogenic pulmonary edema (NPE) is a well-known complication of acute brain injury. Neurogenic stunned myocardium (NSM) occurs clinically in a significant subset of patients with NPE...
- Chest ultrasonography for the diagnosis and monitoring of high-altitude pulmonary edema
Peter J Fagenholz
MFA, Department of Emergency Medicine, Clinics 115, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02140, USA
Chest 131:1013-8. 2007
The comet-tail technique of chest ultrasonography has been described for the diagnosis of cardiogenic pulmonary edema. This is the first report describing its use for the diagnosis and monitoring of high-altitude pulmonary edema (HAPE), ..
- Negative pressure pulmonary hemorrhage
D R Schwartz
Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston 02114 2696, USA
Chest 115:1194-7. 1999
Negative pressure pulmonary edema, a well-recognized phenomenon, is the formation of pulmonary edema following an acute upper airway obstruction (UAO)...
- Pathogenesis of high altitude pulmonary edema: does alveolar epithelial lining fluid vascular endothelial growth factor exacerbate capillary leak?
Robert J Kaner
Division of Pulmonary and Critical Care Medicine, Department of Genetic Medicine, Weill Medical College of Cornell University, 515 East 71st Street S 1000, New York, NY 10021, USA
High Alt Med Biol 5:399-409. 2004
..to result in compromise of alveolar epithelial tight junctions and experimental animal studies in which pulmonary edema is induced when VEGF is overexpressed in the alveolar epithelium, suggest a mechanism...
- Platelet count and function at high altitude and in high-altitude pulmonary edema
Dept of Internal Medicine, Kantonsspital, CH 7000 Chur, Switzerland
J Appl Physiol 100:690-4. 2006
..exposure on platelet function as part of a larger study on 30 subjects with a history of high-altitude pulmonary edema (HAPE) and 10 healthy controls...
- A comparison of continuous and bi-level positive airway pressure non-invasive ventilation in patients with acute cardiogenic pulmonary oedema: a meta-analysis
Kwok M Ho
Department of Intensive Care, Royal Perth Hospital, Perth, Western Australia, Australia
Crit Care 10:R49. 2006
- Association of polymorphisms in pulmonary surfactant protein A1 and A2 genes with high-altitude pulmonary edema
Institute of Genomics and Integrative Biology, Delhi, India
Chest 128:1611-9. 2005
A potential pathogenetic cofactor for the development of high-altitude pulmonary edema (HAPE) is an increase in capillary permeability, which could occur as a result of an inflammatory reaction and/or free-radical-mediated injury to the ..
- Effects of altitude and exercise on pulmonary capillary integrity: evidence for subclinical high-altitude pulmonary edema
Marlowe W Eldridge
John Rankin Laboratory of Pulmonary Medicine, Department of Pediatrics, Univ of Wisconsin, Medical School, H4 422 Clinical Sciences Center, 600 Highland Ave, Madison, WI 53792 4108, USA
J Appl Physiol (1985) 100:972-80. 2006
Strenuous exercise may be a significant contributing factor for development of high-altitude pulmonary edema, particularly at low or moderate altitudes...
- Neurogenic pulmonary edema
Departement d Anesthesie Reanimation, Centre Hospitalier Universitaire de Nancy, Hopital Central, Nancy, France
Acta Anaesthesiol Scand 51:447-55. 2007
Neurogenic pulmonary edema (NPE) is usually defined as an acute pulmonary edema occurring shortly after a central neurologic insult...
- Usefulness of lung ultrasound in the bedside distinction between pulmonary edema and exacerbation of COPD
Department of Emergency Medicine, University of Torino, San Luigi Gonzaga Hospital, Orbassano, Torino, Italy
Emerg Radiol 15:145-51. 2008
..causes of acute dyspnea in the emergency setting, particularly focusing on differential diagnosis of pulmonary edema and exacerbation of chronic obstructive pulmonary disease (COPD)...
- Low degree of anesthesia increases the risk of neurogenic pulmonary edema development
Institute of Experimental Medicine, ASCR, Prague, Czech Republic
Med Hypotheses 70:308-13. 2008
Neurogenic pulmonary edema is an acute life-threatening complication following central nervous system injury. The exact pathogenic mechanism leading to its development is still unclear...
- The detrimental role of inducible nitric oxide synthase in the pulmonary edema caused by hypercalcemia in conscious rats and isolated lungs
Hsing I Chen
Institute of Medical Sciences and of Integrative Physiology and Clinical Sciences, Tzu Chi University, Hualien, Taiwan
J Biomed Sci 15:227-38. 2008
We aim to test the hypothesis that hypercalcemia produces pulmonary edema (PE) and to elucidate the mechanism. Experimentations were carried out in conscious rats and isolated perfused rat lungs...
- Acute pulmonary edema, capillaritis and alveolar hemorrhage: pulmonary manifestations coexistent in antiphospholipid syndrome and systemic lupus erythematosus?
V A Nguyen
Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria
Lupus 14:557-60. 2005
..described the radiological features of three patients with pulmonary and SLE-associated APS, manifested with pulmonary edema, capillaritis and alveolar hemorrhage...
- [The gynecological TURP syndrome. Severe hyponatremia and pulmonary edema during hysteroscopy]
Klinik fur Anasthesiologie und Operative Intensivmedizin, Universitätsklinikum Schleswig Holstein UKSH, Campus Kiel, Schwanenweg 21, 24105 Kiel, Deutschland
Anaesthesist 58:30-4. 2009
..under general anaesthesia, suffering from severe absorption syndrome leading to hyponatremia of 106 mEq/l and pulmonary edema necessitating subsequent admission to ICU...
- Severe subarachnoid hemorrhage with pulmonary edema successfully treated by intra-aneurysmal embolization using Guglielmi detachable coils--Two case reports
Department of Neurosurgery, Aomori Prefectural Central Hospital, Aomori
Neurol Med Chir (Tokyo) 41:135-9. 2001
..Both patients were comatose on admission. Chest radiography disclosed pulmonary edema. They were conservatively treated under controlled ventilation, but cardiopulmonary dysfunction persisted ..
- Evaluation of a thoracic ultrasound training module for the detection of pneumothorax and pulmonary edema by prehospital physician care providers
Vicki E Noble
Department of Emergency Medicine, Massachusetts General Hospital, 55 Fruit St, Boston, Massachusetts, USA
BMC Med Educ 9:3. 2009
..skills for two important TUS applications; the identification of B-lines (used in the US diagnosis of pulmonary edema) and the identification of lung sliding and comet tails (used in the US diagnosis of pneumothorax)...
- Thoracic impedance vs chest radiograph to diagnose acute pulmonary edema in the ED
Department of Emergency Medicine, Georgetown University Medical Center and Washington Hospital Center, Washington, DC 20010, USA
Am J Emerg Med 27:770-5. 2009
We sought to investigate the relationship between thoracic impedance (Zo) and pulmonary edema on chest radiography in patients presenting to the emergency department (ED) with signs and symptoms of acute decompensated heart failure (ADHF).
- Na,K-ATPase overexpression improves alveolar fluid clearance in a rat model of elevated left atrial pressure
Zaher S Azzam
Technion, Israel Institute of Technology, Haifa, Israel
Circulation 105:497-501. 2002
..We reasoned that adenovirus-mediated transfer of an Na,K-ATPase beta-subunit gene to the alveolar epithelium could improve AFC in rat lungs in the presence of acutely elevated LAP...
- Frequent subclinical high-altitude pulmonary edema detected by chest sonography as ultrasound lung comets in recreational climbers
Institute of Clinical Physiology, CNR, Pisa, Italy
Crit Care Med 38:1818-23. 2010
..The aim of this study was to evaluate, by chest sonography, the incidence of interstitial pulmonary edema in recreational high-altitude climbers.
- Lung epithelial fluid transport and the resolution of pulmonary edema
Michael A Matthay
Cardiovascular Research Institute and Department of Medicine, University of California, San Francisco, California 94143 0624, USA
Physiol Rev 82:569-600. 2002
..at the time of birth as well as in the mature lung when pathological conditions lead to the development of pulmonary edema. Currently, the best described molecular transporters are the epithelial sodium channel, the cystic fibrosis ..
- Alveolar edema fluid clearance and acute lung injury
Département de médecine et Centre de recherche du Centre Hospitalier de l Université de Montréal, Universite de Montreal, Montreal, Quebec, Canada
Respir Physiol Neurobiol 159:350-9. 2007
- Survival after pulmonary edema due to enterovirus 71 encephalitis
M A Nolan
Division of Neurology, Sydney Children s Hospital, NSW, Australia
Neurology 60:1651-6. 2003
A distinctive pattern of enterovirus 71 (EV71) infection, characterized by fever, exanthem, acute pulmonary edema (PE), brainstem encephalitis, and flaccid paresis, affects infants and young children...
- Quantification of lung water by transpulmonary thermodilution in normal and edematous lung
Hospital Universitario Virgen de las Nieves, Granada, Spain
J Crit Care 18:253-8. 2003
..To analyze the accuracy of the transpulmonary thermodilution method in the determination of extravascular lung water (EVLW)...
- Role of lung-marginated monocytes in an in vivo mouse model of ventilator-induced lung injury
Michael R Wilson
Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea, United Kingdom
Am J Respir Crit Care Med 179:914-22. 2009
..Inflammatory subset Gr-1(high) monocytes are recruited to sites of inflammation and have been implicated in acute lung injury induced by systemic endotoxin...
- Defective respiratory amiloride-sensitive sodium transport predisposes to pulmonary oedema and delays its resolution in mice
Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland
J Physiol 560:857-65. 2004
..These data in mice strengthen indirect evidence provided by clinical studies, suggesting that defective respiratory transepithelial sodium transport may also facilitate pulmonary oedema in humans...
- New classification and clinical characteristics of reexpansion pulmonary edema after treatment of spontaneous pneumothorax
Yun Kwon Kim
Department of Emergency Medicine, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea
Am J Emerg Med 27:961-7. 2009
Reexpansion pulmonary edema (REPE) is a rare yet sometimes fatal complication associated with the treatment of lung diseases such as pleural effusion, pneumothorax, and hemothorax...
- Inflammatory cytokines in BAL fluid and pulmonary hemodynamics in high-altitude pulmonary edema
First Department of Internal Medicine, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
Respir Physiol 111:301-10. 1998
To evaluate the pathogenesis of high-altitude pulmonary edema (HAPE), we performed bronchoalveolar lavage (BAL) and pulmonary hemodynamic studies in seven patients with HAPE at its early stage...
- Endothelial pathomechanisms in acute lung injury
Nikolaos A Maniatis
M Simou Laboratory, University of Athens Medical School, Athens, Greece
Vascul Pharmacol 49:119-33. 2008
..and its most severe extreme the acute respiratory distress syndrome (ARDS) refer to increased-permeability pulmonary edema caused by a variety of pulmonary or systemic insults...
- Therapeutic efficacy of milrinone in the management of enterovirus 71-induced pulmonary edema
Shih Min Wang
Department of Emergency Medicine, College of Medicine, National Cheng Kung University and Hospital, Tainan, Taiwan
Pediatr Pulmonol 39:219-23. 2005
..Brain-stem encephalitis and pulmonary edema are severe complications that can lead to death...
- Cardiovascular and pulmonary effects of NOS inhibition in endotoxemic conscious rats subjected to swimming training
Department of Physiological Sciences, State University of Londrina, Campus Universitario, CEP 86055 900 Londrina, PR, Brazil
Life Sci 81:1301-8. 2007
..induced by LPS, a model of experimental endotoxemia, and to evaluate the role of nitric oxide (NO) in pulmonary edema. Wistar rats were subjected to swimming training (up to 1 h/day, 5 days/week for 4 weeks) after which their ..
- Berberine inhibits cytosolic phospholipase A2 and protects against LPS-induced lung injury and lethality independent of the alpha2-adrenergic receptor in mice
Hao qing Zhang
Department of Pathophysiology, Medical College of Jinan University, Guangzhou, Guangdong, China
Shock 29:617-22. 2008
..Here, we report that pretreatment with Ber significantly reduced pulmonary edema, neutrophil infiltration, and histopathological alterations; inhibited protein expression and phosphorylation ..
- Noninvasive ventilation in acute cardiogenic pulmonary edema: systematic review and meta-analysis
ICU Department, Hospital Dos de Maig Consorci Sanitari Integral, University of Barcelona, Barcelona, Spain
JAMA 294:3124-30. 2005
In patients with acute cardiogenic pulmonary edema noninvasive ventilation may reduce intubation rate, but the impact on mortality and the superiority of one technique over another have not been clearly established.
- Bedside lung ultrasound in the assessment of alveolar-interstitial syndrome
Department of Emergency Medicine, S Luigi Hospital, Orbassano, TO, 10043, Italy
Am J Emerg Med 24:689-96. 2006
- Alveolar epithelial beta2-adrenergic receptors
Gokhan M Mutlu
Northwestern University Feinberg School of Medicine, Pulmonary and Critical Care Medicine, 240 E Huron Street, McGaw M 300, Chicago, IL 60611, USA
Am J Respir Cell Mol Biol 38:127-34. 2008
..agonists to accelerate alveolar fluid clearance in patients with cardiogenic and noncardiogenic pulmonary edema. In this review, we summarize the role of beta(2)-adrenergic receptors in the alveolar epithelium with ..
- Clara cell protein (CC16), a marker of lung epithelial injury, is decreased in plasma and pulmonary edema fluid from patients with acute lung injury
Jonathan A Kropski
Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 2650, USA
Chest 135:1440-7. 2009
..We tested the diagnostic and prognostic utility of CC16 in patients with non-trauma-related ALI/ARDS compared to a control group of patients with acute cardiogenic pulmonary edema (CPE).
- "Ultrasound comet-tail images": a marker of pulmonary edema: a comparative study with wedge pressure and extravascular lung water
Division of Non Invasive Cardiology, Cardiothoracic Department, San Raffaele Hospital, Istituto di Richerche e Cura a carattere Scientifico, Milano, Italy
Chest 127:1690-5. 2005
Echographic examination of the lung surface may reveal multiple "comet-tail images" originating from water-thickened interlobular septa. These images could be useful for noninvasive assessment of interstitial pulmonary edema.