pulmonary edema

Summary

Top Publications

  1. ncbi Swimming-induced pulmonary edema in triathletes
    Charles C Miller
    Department of Biomedical Sciences, Texas Tech University Health Sciences Center at El Paso Paul L Foster School of Medicine, El Paso, TX 79905, USA
    Am J Emerg Med 28:941-6. 2010
  2. ncbi Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles of cytokines and cellular immune activation in patients with pulmonary edema
    Shih Min Wang
    Department of Emergency Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
    J Infect Dis 188:564-70. 2003
  3. pmc Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management
    Michael A Matthay
    Department of Medicine, Cardiovascular Research and Training Institute, University of California at San Francisco, San Francisco, California 94143 0130, USA
    Am J Respir Cell Mol Biol 33:319-27. 2005
  4. ncbi Update on high-altitude pulmonary edema: pathogenesis, prevention, and treatment
    Joshua O Stream
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA
    Wilderness Environ Med 19:293-303. 2008
  5. ncbi Protein kinase C modulates pulmonary endothelial permeability: a paradigm for acute lung injury
    Alma Siflinger-Birnboim
    Research Service, Stratton Veterans Affairs Medical Center and the Center for Cardiovascular Science, The Albany Medical College, Albany, New York 12208, USA
    Am J Physiol Lung Cell Mol Physiol 284:L435-51. 2003
  6. pmc Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema
    Carole A Oskeritzian
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    J Exp Med 207:465-74. 2010
  7. ncbi Lung overexpression of the vascular endothelial growth factor gene induces pulmonary edema
    R J Kaner
    Division of Pulmonary and Critical Care Medicine and Weill Medical College of Cornell University, New York, New York, USA
    Am J Respir Cell Mol Biol 22:657-64. 2000
  8. pmc Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells
    Mohammad Tauseef
    Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Circ Res 103:1164-72. 2008
  9. ncbi Extravascular lung water indexed to predicted body weight is a novel predictor of intensive care unit mortality in patients with acute lung injury
    Thelma R Craig
    Regional Intensive Care Unit, Royal Victoria Hospital, Belfast, UK
    Crit Care Med 38:114-20. 2010
  10. ncbi Prevention and treatment of high-altitude pulmonary edema
    Marco Maggiorini
    Intensive Care Unit, Department of Internal Medicine, University Hospital, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Prog Cardiovasc Dis 52:500-6. 2010

Detail Information

Publications369 found, 100 shown here

  1. ncbi Swimming-induced pulmonary edema in triathletes
    Charles C Miller
    Department of Biomedical Sciences, Texas Tech University Health Sciences Center at El Paso Paul L Foster School of Medicine, El Paso, TX 79905, USA
    Am J Emerg Med 28:941-6. 2010
    b>Pulmonary edema related to water immersion has been reported in military trainees and scuba and breath-hold divers, but rarely in the community. To date, no risk factors for this phenomenon have been identified by epidemiological methods...
  2. ncbi Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles of cytokines and cellular immune activation in patients with pulmonary edema
    Shih Min Wang
    Department of Emergency Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
    J Infect Dis 188:564-70. 2003
    ..epidemics of enterovirus 71 (EV71) infections, which were associated with brainstem encephalitis (BE) and pulmonary edema (PE)...
  3. pmc Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management
    Michael A Matthay
    Department of Medicine, Cardiovascular Research and Training Institute, University of California at San Francisco, San Francisco, California 94143 0130, USA
    Am J Respir Cell Mol Biol 33:319-27. 2005
  4. ncbi Update on high-altitude pulmonary edema: pathogenesis, prevention, and treatment
    Joshua O Stream
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA
    Wilderness Environ Med 19:293-303. 2008
    High-altitude pulmonary edema (HAPE) is a life-threatening noncardiogenic form of pulmonary edema (PE) that afflicts susceptible persons after rapid ascent to high altitude above 2500 m...
  5. ncbi Protein kinase C modulates pulmonary endothelial permeability: a paradigm for acute lung injury
    Alma Siflinger-Birnboim
    Research Service, Stratton Veterans Affairs Medical Center and the Center for Cardiovascular Science, The Albany Medical College, Albany, New York 12208, USA
    Am J Physiol Lung Cell Mol Physiol 284:L435-51. 2003
    The intracellular serine/threonine kinase protein kinase C (PKC) has an important role in the genesis of pulmonary edema. This review discusses the PKC-mediated mechanisms that participate in the pulmonary endothelial response to agents ..
  6. pmc Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema
    Carole A Oskeritzian
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    J Exp Med 207:465-74. 2010
    ..E-triggered anaphylactic responses, including elevation of circulating histamine and associated pulmonary edema in mice, were significantly attenuated by the S1P(2) antagonist JTE-013 and in S1P(2)-deficient mice, in ..
  7. ncbi Lung overexpression of the vascular endothelial growth factor gene induces pulmonary edema
    R J Kaner
    Division of Pulmonary and Critical Care Medicine and Weill Medical College of Cornell University, New York, New York, USA
    Am J Respir Cell Mol Biol 22:657-64. 2000
    ..an identical adenovirus vector with an irrelevant transgene had no effect upon subsequent AdVEGF165-induced pulmonary edema. Together, these data suggest that overexpression of VEGF in the lung may be one mechanism of increased ..
  8. pmc Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells
    Mohammad Tauseef
    Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Circ Res 103:1164-72. 2008
    ..In contrast to wild-type mice, Sphk1(-/-) mice showed markedly enhanced pulmonary edema formation in response to lipopolysaccharide and PAR-1 activation...
  9. ncbi Extravascular lung water indexed to predicted body weight is a novel predictor of intensive care unit mortality in patients with acute lung injury
    Thelma R Craig
    Regional Intensive Care Unit, Royal Victoria Hospital, Belfast, UK
    Crit Care Med 38:114-20. 2010
    Acute lung injury and the acute respiratory distress syndrome are characterized by noncardiogenic pulmonary edema, which can be assessed by measurement of extravascular lung water...
  10. ncbi Prevention and treatment of high-altitude pulmonary edema
    Marco Maggiorini
    Intensive Care Unit, Department of Internal Medicine, University Hospital, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Prog Cardiovasc Dis 52:500-6. 2010
    ..altitude illness, a cerebral form called acute mountain sickness and a pulmonary form called high-altitude pulmonary edema (HAPE). Individual susceptibility is the most important determinant for the occurrence of HAPE...
  11. ncbi Sodium tanshinone iia sulfonate attenuates seawater aspiration-induced acute pulmonary edema by up-regulating Na(+),K(+)-ATPase activity
    Xiao Yan Xie
    Department of Respiratory Medicine, Tangdu Hospital, Fourth Military Medical University, Xi an, Shaanxi, PR China
    Exp Lung Res 37:482-91. 2011
    Relieving pulmonary edema is the key of a successful treatment to seawater drowning. Sodium tanshinone IIA sulfonate (STS) has been observed to reduce lung edema from lipopolysaccharide (LPS)-induced lung injury...
  12. ncbi Non-invasive pressure support ventilation versus conventional oxygen therapy in acute cardiogenic pulmonary oedema: a randomised trial
    J Masip
    Cardiology Department, Consorci Sanitari Creu Roja de Catalunya, Hospital Creu Roja de Barcelona, University of Barcelona, Spain
    Lancet 356:2126-32. 2000
    ..We assessed the efficacy of this therapy in acute cardiogenic pulmonary oedema in a randomised comparison with conventional oxygen therapy...
  13. ncbi Anti-asthmatic agents alleviate pulmonary edema by upregulating AQP1 and AQP5 expression in the lungs of mice with OVA-induced asthma
    Chunling Dong
    Department of Pulmonary Medicine, Research Institute of Respiratory Disease, Zhongshan Hospital, Fudan University, Shanghai 200032, China
    Respir Physiol Neurobiol 181:21-8. 2012
    ..Dexamethasone and ambroxol improved the eosinophil infiltration, mucus secretion, and pulmonary edema caused by OVA, but terbutaline only alleviated pulmonary edema...
  14. pmc Caspase-1 inhibitor prevents neurogenic pulmonary edema after subarachnoid hemorrhage in mice
    Hidenori Suzuki
    Stroke 40:3872-5. 2009
    We examined the effects of a caspase-1 inhibitor, N-Ac-Tyr-Val-Ala-Asp-chloromethyl ketone (Ac-YVAD-CMK), on neurogenic pulmonary edema in the endovascular perforation model of subarachnoid hemorrhage (SAH) in mice.
  15. ncbi Lung edema clearance: 20 years of progress: invited review: role of aquaporin water channels in fluid transport in lung and airways
    Zea Borok
    Will Rogers Institute Pulmonary Research Center, Department of Medicine, University of Southern California, Los Angeles 90033 3721, USA
    J Appl Physiol 93:2199-206. 2002
    ..However, the possibility remains that AQPs may play a role in lung physiology under conditions of stress and/or injury not yet tested or in functions unrelated to transepithelial fluid transport...
  16. ncbi Barrier enhancing signals in pulmonary edema
    Konstantin G Birukov
    Lung Injury Center, Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, Illinois, USA
    Compr Physiol 3:429-84. 2013
    ..permeability and reduction of alveolar liquid clearance capacity are two leading pathogenic mechanisms of pulmonary edema, which is a major complication of acute lung injury, severe pneumonia, and acute respiratory distress ..
  17. ncbi High-altitude pulmonary edema
    Norbert F Voelkel
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    N Engl J Med 346:1606-7. 2002
  18. ncbi Predictors of the first heart failure hospitalization in patients who are stable survivors of myocardial infarction complicated by pulmonary congestion and/or left ventricular dysfunction: a VALIANT study
    Eldrin F Lewis
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Eur Heart J 29:748-56. 2008
    ..We sought to assess the incidence of and prognostic factors for heart failure (HF) hospitalization among survivors of high-risk acute myocardial infarction (MI)...
  19. ncbi Saturated hydrogen saline protects the lung against oxygen toxicity
    Juan Zheng
    Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China
    Undersea Hyperb Med 37:185-92. 2010
    ..These results demonstrated that saturated hydrogen saline alleviated hyperoxia-induced pulmonary injury, which was partly responsible for the inhibition of oxidative damage...
  20. ncbi The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome
    J Pugin
    Department of Internal Medicine, University Hospital of Geneva, Switzerland
    Crit Care Med 27:304-12. 1999
    ..the concentrations of proinflammatory mediators, collagenases, and procollagen type III peptides in undiluted pulmonary edema fluids and in plasma obtained in patients with early acute respiratory distress syndrome (ARDS) and in ..
  21. ncbi Modulation of cytokine production by intravenous immunoglobulin in patients with enterovirus 71-associated brainstem encephalitis
    Shih Min Wang
    Department of Emergency Medicine, National Cheng Kung University and Hospital, 138 Sheng Li Road, 70428 Tainan, Taiwan
    J Clin Virol 37:47-52. 2006
    ..Several epidemics of enterovirus 71 (EV71) infections occurred in Taiwan since 1998...
  22. ncbi Pathogenesis of high-altitude pulmonary edema: inflammation is not an etiologic factor
    Erik R Swenson
    Pulmonary and Critical Care Section, S 111 Pulm, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    JAMA 287:2228-35. 2002
    The pathogenesis of high-altitude pulmonary edema (HAPE) is considered an altered permeability of the alveolar-capillary barrier secondary to intense pulmonary vasoconstriction and high capillary pressure, but previous bronchoalveolar ..
  23. ncbi Synergistic effect of the genetic polymorphisms of the renin-angiotensin-aldosterone system on high-altitude pulmonary edema: a study from Qinghai-Tibet altitude
    Yue Qi
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences Peking Union Medical College, No 5 Dong Dan San Tiao, Beijing 100005, China
    Eur J Epidemiol 23:143-52. 2008
    The pathogenesis of high-altitude pulmonary edema (HAPE) has been at least partially attributed to the local dysregulation of the renin-angiotensin-aldosterone system (RAAS) cascade...
  24. ncbi Physiological aspects of high-altitude pulmonary edema
    Peter Bartsch
    Department of Internal Medicine VII, Division of Sports Medicine, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    J Appl Physiol (1985) 98:1101-10. 2005
    High-altitude pulmonary edema (HAPE) develops in rapidly ascending nonacclimatized healthy individuals at altitudes above 3,000 m...
  25. ncbi Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN
    Teresa Sanchez
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030 3501, USA
    Arterioscler Thromb Vasc Biol 27:1312-8. 2007
    ..However, cellular consequences of S1P2R signaling in the vascular cells are not well understood...
  26. ncbi Emerging themes of cAMP regulation of the pulmonary endothelial barrier
    Sarah L Sayner
    Dept of Cell Biology and Neuroscience, Member, Center for Lung Biology, College of Medicine, Univ of South Alabama, Mobile, AL 36688, USA
    Am J Physiol Lung Cell Mol Physiol 300:L667-78. 2011
    ....
  27. ncbi Pathophysiology of acute lung injury and the acute respiratory distress syndrome
    Lorraine B Ware
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Semin Respir Crit Care Med 27:337-49. 2006
    ..Future therapies aimed at restoring the overall balance of cytokines, oxidants, coagulants, and proteases may ultimately be successful where therapies that target individual cytokines or other mediators have not...
  28. ncbi Hypoxia impairs systemic endothelial function in individuals prone to high-altitude pulmonary edema
    Marc M Berger
    Department of Internal Medicine VI Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Germany
    Am J Respir Crit Care Med 172:763-7. 2005
    High-altitude pulmonary edema (HAPE) is characterized by excessive pulmonary vasoconstriction and is associated with decreased concentrations of nitric oxide (NO) in the lung...
  29. pmc Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung
    Jae W Lee
    Department of Anesthesiology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:16357-62. 2009
    ..coli endotoxin. Intra-bronchial instillation of endotoxin into the distal airspaces resulted in pulmonary edema with the loss of alveolar epithelial fluid transport measured as alveolar fluid clearance...
  30. ncbi Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury
    Daniel F McAuley
    Cardiovascular Research Institute, University of California, San Francisco, CA, USA
    Crit Care Med 32:1470-6. 2004
    ..clinically relevant airspace concentrations of beta2-adrenergic agonists stimulated maximal alveolar fluid clearance rates and to determine whether beta2 agonist therapy decreased pulmonary edema in experimental acute lung injury.
  31. ncbi Deaths in children during an outbreak of hand, foot and mouth disease in Peninsular Malaysia--clinical and pathological characteristics
    K Shekhar
    University of Malaya, Kuala Lumpur
    Med J Malaysia 60:297-304. 2005
    ....
  32. ncbi New insights in the pathogenesis of high-altitude pulmonary edema
    Urs Scherrer
    Department of Internal Medicine and the Botnar Center for Extreme Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Prog Cardiovasc Dis 52:485-92. 2010
    High-altitude pulmonary edema is a life-threatening condition occurring in predisposed but otherwise healthy individuals...
  33. ncbi Usefulness of ultrasound lung comets as a nonradiologic sign of extravascular lung water
    Zoltan Jambrik
    Institute of Clinical Physiology, CNR Lab, Via Moruzzi 1, 56123 Pisa, Italy
    Am J Cardiol 93:1265-70. 2004
    ....
  34. ncbi Noninvasive ventilation in acute cardiogenic pulmonary edema: a meta-analysis of randomized controlled trials
    Javier Mariani
    Grupo de Estudio, Docencia e Investigación Clínica, Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
    J Card Fail 17:850-9. 2011
    The evidence of individual studies in acute cardiogenic pulmonary edema (ACPE) supporting noninvasive ventilation (NIV) is still inconclusive, particularly regarding noninvasive positive pressure ventilation (NIPPV).
  35. ncbi Reexpansion pulmonary edema
    Yasunori Sohara
    Department of Surgery, Faculty of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Ann Thorac Cardiovasc Surg 14:205-9. 2008
    When a rapidly reexpanding lung has been in a state of collapse for more than several days, pulmonary edema sometimes occurs in it. This is called reexpansion pulmonary edema (RPE)...
  36. ncbi Functional identification of the alveolar edema reabsorption activity of murine tumor necrosis factor-alpha
    Nadia Elia
    Division of Anesthesiological Investigations, University Medical Center, Geneva, Switzerland
    Am J Respir Crit Care Med 168:1043-50. 2003
    ..There was also a significant reduction in lung water. These results indicate that the receptor-independent lectin-like domain of mTNF-alpha has a potential physiological role in the resolution of alveolar edema in rats and mice...
  37. ncbi Secular trends in nosocomial infections and mortality associated with noninvasive ventilation in patients with exacerbation of COPD and pulmonary edema
    Emmanuelle Girou
    Unité d Hygiène et Prévention de l Infection, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, Creteil, France
    JAMA 290:2985-91. 2003
    ..But whether these benefits translate to a clinical setting is unclear...
  38. ncbi Serial measurement of extravascular lung water and blood volume during the course of neurogenic pulmonary edema after subarachnoid hemorrhage: initial experience with 3 cases
    Tatsushi Mutoh
    Department of Surgical Neurology, Research Institute for Brain and Blood Vessels, Akita, Japan
    J Neurosurg Anesthesiol 24:203-8. 2012
    Neurogenic pulmonary edema (NPE) as a systemic consequence early after aneurysmal subarachnoid hemorrhage (SAH) sometimes complicates perioperative and postoperative fluid management and increases the risk of a poor outcome...
  39. ncbi High altitude pulmonary edema: a pressure-induced leak
    Christoph Dehnert
    Medical University Clinic, Department of Internal Medicine, Div of Sports Medicine, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Respir Physiol Neurobiol 158:266-73. 2007
    High altitude pulmonary edema (HAPE) is a non-cardiogenic pulmonary edema that can occur in healthy individuals who ascend rapidly to altitudes above 3000-4000m...
  40. ncbi Acute pulmonary edema in pregnancy
    Anthony C Sciscione
    Department of Obstetrics and Gynecology, Maternal Fetal Medicine Division, Christiana Care Health Services, 4755 Ogletown Stanton Road, Newark, DE 19718, USA
    Obstet Gynecol 101:511-5. 2003
    To describe the incidence, predisposing conditions, and inciting factors culminating in pulmonary edema in the pregnant patient.
  41. ncbi Boussignac continuous positive airway pressure device in the emergency care of acute cardiogenic pulmonary oedema: a randomized pilot study
    Fabienne Moritz
    Emergency Department, CHU de Rouen, Hopital Charles Nicolle, 1 rue de Germont, 76031 Rouen Cedex, France
    Eur J Emerg Med 10:204-8. 2003
    ..It can quickly improve respiratory distress in acute cardiogenic pulmonary oedema patients. A larger trial should be initiated in such an emergency care setting to demonstrate the effectiveness of the Boussignac-CPAP device...
  42. ncbi N-acetylcysteine prevents pulmonary edema and acute kidney injury in rats with sepsis submitted to mechanical ventilation
    Renata Campos
    Laboratory for Medical Research, Nephrology Department, University of SãoPaulo School of Medicine, Sao Paulo, Brazil
    Am J Physiol Lung Cell Mol Physiol 302:L640-50. 2012
    ..The protective effects of NAC (against kidney and lung injury) are likely attributable to the decrease in oxidative stress, suggesting that NAC can be useful in the treatment of sepsis...
  43. ncbi Microarray analysis indicates that pulmonary edema fluid from patients with acute lung injury mediates inflammation, mitogen gene expression, and fibroblast proliferation through bioactive interleukin-1
    Mitchell A Olman
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, The University of Alabama, Birmingham, AL 35294, USA
    Chest 121:69S-70S. 2002
  44. pmc Randomised controlled comparison of continuous positive airways pressure, bilevel non-invasive ventilation, and standard treatment in emergency department patients with acute cardiogenic pulmonary oedema
    S D Crane
    Department of Emergency Medicine, Leeds General Infirmary, UK
    Emerg Med J 21:155-61. 2004
    ..The efficacy of both treatments was assessed in the UK emergency department setting, in a randomised comparison with standard oxygen therapy...
  45. ncbi The lectin-like domain of tumor necrosis factor-alpha improves alveolar fluid balance in injured isolated rabbit lungs
    István Vadász
    University of Giessen Lung Center, Giessen, Germany
    Crit Care Med 36:1543-50. 2008
    Identification of mechanisms that preserve optimal alveolar fluid balance during pulmonary edema is of great clinical importance...
  46. ncbi Randomized, prospective trial of oxygen, continuous positive airway pressure, and bilevel positive airway pressure by face mask in acute cardiogenic pulmonary edema
    Marcelo Park
    Division of Emergency Medicine, Heart Institute InCor, Hospital das Clinicas, University of Sao Paulo, Brazil
    Crit Care Med 32:2407-15. 2004
    To compare the effects of oxygen, continuous positive airway pressure (CPAP), and bilevel positive airway pressure (bilevel-PAP) on the rate of endotracheal intubation in patients with acute cardiogenic pulmonary edema.
  47. ncbi Doxycycline induces membrane expression of VE-cadherin on endothelial cells and prevents vascular hyperpermeability
    Ofer Fainaru
    Vascular Biology Program, Children s Hospital Boston, Department of Surgery, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
    FASEB J 22:3728-35. 2008
    ..g., inflammatory and hypersensitivity disorders, pulmonary edema, traumatic lung injury, cerebral edema resulting from stroke, and others), it is important to develop ..
  48. ncbi Alveolar epithelial fluid transport in acute lung injury: new insights
    C Sartori
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143 0130, USA
    Eur Respir J 20:1299-313. 2002
    ..Very recent data suggest that mechanisms that augment transepithelial sodium transport and enhance the clearance of alveolar oedema may lead to more effective prevention or treatment for some types of pulmonary oedema...
  49. ncbi Role of oxidative stress and NFkB in hypoxia-induced pulmonary edema
    Sagi Sarada
    Department of Experimental Biology, Defense Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi 54, India
    Exp Biol Med (Maywood) 233:1088-98. 2008
    ..increased oxidative stress further upregulates the nuclear transcription factor (NFkB) in the development of pulmonary edema. The rats were exposed to hypobaric hypoxia at 7620 m (280 mm Hg) for different durations, that is, 3 hrs, 6 ..
  50. ncbi Myocardial infarction rate in acute pulmonary edema: noninvasive pressure support ventilation versus continuous positive airway pressure
    Andrea Bellone
    Emergency Department, Niguarda Ca Granda Hospital, P za Ospedale, Milano, Italy
    Crit Care Med 32:1860-5. 2004
    ..support ventilation (NIPSV) delivered by face mask has proved an effective treatment for patients with acute pulmonary edema. However, an increase in acute myocardial infarction rate has been reported with this ventilation modality...
  51. ncbi Milrinone therapy for enterovirus 71-induced pulmonary edema and/or neurogenic shock in children: a randomized controlled trial
    Chia Yu Chi
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli County, Taiwan
    Crit Care Med 41:1754-60. 2013
    Enterovirus 71-induced brainstem encephalitis with pulmonary edema and/or neurogenic shock (stage 3B) is associated with rapid mortality in children...
  52. ncbi Simvastatin regulates CXC chemokine formation in streptococcal M1 protein-induced neutrophil infiltration in the lung
    Songen Zhang
    Department of Clinical Sciences, Section for Surgery, Malmo University Hospital, Lund University, Sweden
    Am J Physiol Lung Cell Mol Physiol 300:L930-9. 2011
    ..Thus, simvastatin may be a useful tool to ameliorate acute lung injury in streptococcal infections...
  53. ncbi Identification of haptoglobin and apolipoprotein A-I as biomarkers for high altitude pulmonary edema
    Yasmin Ahmad
    Peptide and Proteomics Division, Defence Institute of Physiology and Allied Sciences, Defence Research and Development Organization, Ministry of Defence, Delhi, India
    Funct Integr Genomics 11:407-17. 2011
    ..and matrix-assisted laser desorption/ionization tandem time of flight from patients with high altitude pulmonary edema (HAPE)...
  54. ncbi Circulatory characteristics of normovolemia and normotension therapy after subarachnoid hemorrhage, focusing on pulmonary edema
    Yohei Sato
    Department of Neurosurgery, Tokyo Medical and Dental University, Yushima, Bunkyo ku, Japan
    Acta Neurochir (Wien) 154:2195-202. 2012
    Cardiopulmonary complications are common after subarachnoid hemorrhage (SAH), and include pulmonary edema (PE)...
  55. ncbi Streptococcal M1 protein-provoked CXC chemokine formation, neutrophil recruitment and lung damage are regulated by Rho-kinase signaling
    Songen Zhang
    Department of Clinical Sciences, Section for Surgery, Malmo University Hospital, Lund University, Malmo, Sweden
    J Innate Immun 4:399-408. 2012
    ....
  56. pmc Postobstructive pulmonary edema: a case for hydrostatic mechanisms
    Richard D Fremont
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, T1218 MCN, 1161 Twenty First Ave S, Nashville, TN 37232 2650, USA
    Chest 131:1742-6. 2007
    Postobstructive pulmonary edema is a well-recognized complication of upper airway obstruction...
  57. ncbi Neurogenic pulmonary edema in a fatal case of subarachnoid hemorrhage
    Jorg Ahrens
    Department of Anesthesiology, Hannover Medical School, D 30625 Hannover, Germany
    J Clin Anesth 20:129-32. 2008
    Neurogenic pulmonary edema (NPE) is caused by a variety of central nervous system lesions and may appear as a subclinical complication. The fulminant form of NPE is always life-threatening...
  58. ncbi Hypoxic preconditioning with cobalt ameliorates hypobaric hypoxia induced pulmonary edema in rat
    Dhananjay Shukla
    Defence Institute of Physiology and Allied Sciences DIPAS, Lucknow Road, Timarpur, Delhi 110054, India
    Eur J Pharmacol 656:101-9. 2011
    ..considered as an acute physiological stress and often leads to high altitude maladies such as high altitude pulmonary edema (HAPE) and high altitude cerebral edema (HACE)...
  59. pmc Negative pressure pulmonary edema after oral and maxillofacial surgery
    Hideki Mamiya
    Department of Dental Anesthesiology, Tokyo Dental College, Chiba, Japan
    Anesth Prog 56:49-52. 2009
    Negative pressure pulmonary edema (NPPE) following upper airway obstruction (UAO) has been reported in several clinical situations. The main cause of NPPE is reported to be increased negative intrathoracic pressure...
  60. ncbi Assessment of acute pulmonary edema in dogs by electrical impedance imaging
    J C Newell
    Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Ttoy, NY 12180, USA
    IEEE Trans Biomed Eng 43:133-8. 1996
    Acute pulmonary edema was assessed quantitatively in 12 experiments on six anesthetized dogs. Thirty-two copper foil electrodes were placed around each animal's thorax at the level of the third intercostal space...
  61. ncbi Cardiac output increases prior to development of pulmonary edema after re-expansion of spontaneous pneumothorax
    H C Tan
    Division of Cardiology, Changi General Hospital, Singapore
    Respir Med 96:461-5. 2002
    b>Pulmonary edema following reexpansion of spontaneous pneumothorax is an uncommon complication. The underlying mechanism of this condition is unclear...
  62. ncbi Exercise-induced pulmonary edema in heart failure
    Piergiuseppe Agostoni
    Centro Cardiologico Monzino, IRCCS, Istituto di Cardiologia, Universita di Milano, Via Parea 4, 20138 Milan, Italy
    Circulation 108:2666-71. 2003
    ..failure (HF) patients, exercise may increase pulmonary capillary hydrostatic pressure and thereby generate pulmonary edema. If pulmonary edema developed, alveolar-capillary membrane conductance (Dm), measured immediately after ..
  63. pmc Boussignac continuous positive airway pressure for the management of acute cardiogenic pulmonary edema: prospective study with a retrospective control group
    Willem Dieperink
    Thoraxcenter, Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1 P O Box 30, 001, 9700 RB Groningen, The Netherlands
    BMC Cardiovasc Disord 7:40. 2007
    Continuous positive airway pressure (CPAP) treatment for acute cardiogenic pulmonary edema can have important benefits in acute cardiac care...
  64. pmc Chest sonography: a useful tool to differentiate acute cardiogenic pulmonary edema from acute respiratory distress syndrome
    Roberto Copetti
    Emergency Department S, Antonio Abate General Hospital, Tolmezzo, Italy
    Cardiovasc Ultrasound 6:16. 2008
    Differential diagnosis between acute cardiogenic pulmonary edema (APE) and acute lung injury/acute respiratory distress syndrome (ALI/ARDS) may often be difficult...
  65. ncbi Negative pressure pulmonary edema--five case reports
    Islam Massad
    Department of Anaesthesia and Intensive Care, Jordan University Hospital, Amman, Jordan
    Middle East J Anesthesiol 18:977-84. 2006
  66. ncbi Neurogenic pulmonary edema during intracranial endovascular therapy
    Randall P Brewer
    Department of Anesthesiology, Duke University School of Medicine, Durham, NC, USA
    Neurocrit Care 1:423-7. 2004
    Neurogenic pulmonary edema (NPE) is a well-known complication of acute brain injury. Neurogenic stunned myocardium (NSM) occurs clinically in a significant subset of patients with NPE...
  67. ncbi Chest ultrasonography for the diagnosis and monitoring of high-altitude pulmonary edema
    Peter J Fagenholz
    MFA, Department of Emergency Medicine, Clinics 115, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02140, USA
    Chest 131:1013-8. 2007
    The comet-tail technique of chest ultrasonography has been described for the diagnosis of cardiogenic pulmonary edema. This is the first report describing its use for the diagnosis and monitoring of high-altitude pulmonary edema (HAPE), ..
  68. ncbi Negative pressure pulmonary hemorrhage
    D R Schwartz
    Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston 02114 2696, USA
    Chest 115:1194-7. 1999
    Negative pressure pulmonary edema, a well-recognized phenomenon, is the formation of pulmonary edema following an acute upper airway obstruction (UAO)...
  69. ncbi Pathogenesis of high altitude pulmonary edema: does alveolar epithelial lining fluid vascular endothelial growth factor exacerbate capillary leak?
    Robert J Kaner
    Division of Pulmonary and Critical Care Medicine, Department of Genetic Medicine, Weill Medical College of Cornell University, 515 East 71st Street S 1000, New York, NY 10021, USA
    High Alt Med Biol 5:399-409. 2004
    ..to result in compromise of alveolar epithelial tight junctions and experimental animal studies in which pulmonary edema is induced when VEGF is overexpressed in the alveolar epithelium, suggest a mechanism...
  70. ncbi Platelet count and function at high altitude and in high-altitude pulmonary edema
    T Lehmann
    Dept of Internal Medicine, Kantonsspital, CH 7000 Chur, Switzerland
    J Appl Physiol 100:690-4. 2006
    ..exposure on platelet function as part of a larger study on 30 subjects with a history of high-altitude pulmonary edema (HAPE) and 10 healthy controls...
  71. pmc A comparison of continuous and bi-level positive airway pressure non-invasive ventilation in patients with acute cardiogenic pulmonary oedema: a meta-analysis
    Kwok M Ho
    Department of Intensive Care, Royal Perth Hospital, Perth, Western Australia, Australia
    Crit Care 10:R49. 2006
    ....
  72. ncbi Association of polymorphisms in pulmonary surfactant protein A1 and A2 genes with high-altitude pulmonary edema
    Shweta Saxena
    Institute of Genomics and Integrative Biology, Delhi, India
    Chest 128:1611-9. 2005
    A potential pathogenetic cofactor for the development of high-altitude pulmonary edema (HAPE) is an increase in capillary permeability, which could occur as a result of an inflammatory reaction and/or free-radical-mediated injury to the ..
  73. ncbi Effects of altitude and exercise on pulmonary capillary integrity: evidence for subclinical high-altitude pulmonary edema
    Marlowe W Eldridge
    John Rankin Laboratory of Pulmonary Medicine, Department of Pediatrics, Univ of Wisconsin, Medical School, H4 422 Clinical Sciences Center, 600 Highland Ave, Madison, WI 53792 4108, USA
    J Appl Physiol (1985) 100:972-80. 2006
    Strenuous exercise may be a significant contributing factor for development of high-altitude pulmonary edema, particularly at low or moderate altitudes...
  74. ncbi Neurogenic pulmonary edema
    A Baumann
    Departement d Anesthesie Reanimation, Centre Hospitalier Universitaire de Nancy, Hopital Central, Nancy, France
    Acta Anaesthesiol Scand 51:447-55. 2007
    Neurogenic pulmonary edema (NPE) is usually defined as an acute pulmonary edema occurring shortly after a central neurologic insult...
  75. ncbi Usefulness of lung ultrasound in the bedside distinction between pulmonary edema and exacerbation of COPD
    Giovanni Volpicelli
    Department of Emergency Medicine, University of Torino, San Luigi Gonzaga Hospital, Orbassano, Torino, Italy
    Emerg Radiol 15:145-51. 2008
    ..causes of acute dyspnea in the emergency setting, particularly focusing on differential diagnosis of pulmonary edema and exacerbation of chronic obstructive pulmonary disease (COPD)...
  76. ncbi Low degree of anesthesia increases the risk of neurogenic pulmonary edema development
    J Sedy
    Institute of Experimental Medicine, ASCR, Prague, Czech Republic
    Med Hypotheses 70:308-13. 2008
    Neurogenic pulmonary edema is an acute life-threatening complication following central nervous system injury. The exact pathogenic mechanism leading to its development is still unclear...
  77. ncbi The detrimental role of inducible nitric oxide synthase in the pulmonary edema caused by hypercalcemia in conscious rats and isolated lungs
    Hsing I Chen
    Institute of Medical Sciences and of Integrative Physiology and Clinical Sciences, Tzu Chi University, Hualien, Taiwan
    J Biomed Sci 15:227-38. 2008
    We aim to test the hypothesis that hypercalcemia produces pulmonary edema (PE) and to elucidate the mechanism. Experimentations were carried out in conscious rats and isolated perfused rat lungs...
  78. ncbi Acute pulmonary edema, capillaritis and alveolar hemorrhage: pulmonary manifestations coexistent in antiphospholipid syndrome and systemic lupus erythematosus?
    V A Nguyen
    Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria
    Lupus 14:557-60. 2005
    ..described the radiological features of three patients with pulmonary and SLE-associated APS, manifested with pulmonary edema, capillaritis and alveolar hemorrhage...
  79. ncbi [The gynecological TURP syndrome. Severe hyponatremia and pulmonary edema during hysteroscopy]
    G Serocki
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Universitätsklinikum Schleswig Holstein UKSH, Campus Kiel, Schwanenweg 21, 24105 Kiel, Deutschland
    Anaesthesist 58:30-4. 2009
    ..under general anaesthesia, suffering from severe absorption syndrome leading to hyponatremia of 106 mEq/l and pulmonary edema necessitating subsequent admission to ICU...
  80. ncbi Severe subarachnoid hemorrhage with pulmonary edema successfully treated by intra-aneurysmal embolization using Guglielmi detachable coils--Two case reports
    M Fujimura
    Department of Neurosurgery, Aomori Prefectural Central Hospital, Aomori
    Neurol Med Chir (Tokyo) 41:135-9. 2001
    ..Both patients were comatose on admission. Chest radiography disclosed pulmonary edema. They were conservatively treated under controlled ventilation, but cardiopulmonary dysfunction persisted ..
  81. pmc Evaluation of a thoracic ultrasound training module for the detection of pneumothorax and pulmonary edema by prehospital physician care providers
    Vicki E Noble
    Department of Emergency Medicine, Massachusetts General Hospital, 55 Fruit St, Boston, Massachusetts, USA
    BMC Med Educ 9:3. 2009
    ..skills for two important TUS applications; the identification of B-lines (used in the US diagnosis of pulmonary edema) and the identification of lung sliding and comet tails (used in the US diagnosis of pneumothorax)...
  82. ncbi Thoracic impedance vs chest radiograph to diagnose acute pulmonary edema in the ED
    Dave Milzman
    Department of Emergency Medicine, Georgetown University Medical Center and Washington Hospital Center, Washington, DC 20010, USA
    Am J Emerg Med 27:770-5. 2009
    We sought to investigate the relationship between thoracic impedance (Zo) and pulmonary edema on chest radiography in patients presenting to the emergency department (ED) with signs and symptoms of acute decompensated heart failure (ADHF).
  83. ncbi Na,K-ATPase overexpression improves alveolar fluid clearance in a rat model of elevated left atrial pressure
    Zaher S Azzam
    Technion, Israel Institute of Technology, Haifa, Israel
    Circulation 105:497-501. 2002
    ..We reasoned that adenovirus-mediated transfer of an Na,K-ATPase beta-subunit gene to the alveolar epithelium could improve AFC in rat lungs in the presence of acutely elevated LAP...
  84. ncbi Frequent subclinical high-altitude pulmonary edema detected by chest sonography as ultrasound lung comets in recreational climbers
    Lorenza Pratali
    Institute of Clinical Physiology, CNR, Pisa, Italy
    Crit Care Med 38:1818-23. 2010
    ..The aim of this study was to evaluate, by chest sonography, the incidence of interstitial pulmonary edema in recreational high-altitude climbers.
  85. ncbi Lung epithelial fluid transport and the resolution of pulmonary edema
    Michael A Matthay
    Cardiovascular Research Institute and Department of Medicine, University of California, San Francisco, California 94143 0624, USA
    Physiol Rev 82:569-600. 2002
    ..at the time of birth as well as in the mature lung when pathological conditions lead to the development of pulmonary edema. Currently, the best described molecular transporters are the epithelial sodium channel, the cystic fibrosis ..
  86. pmc Alveolar edema fluid clearance and acute lung injury
    Yves Berthiaume
    Département de médecine et Centre de recherche du Centre Hospitalier de l Université de Montréal, Universite de Montreal, Montreal, Quebec, Canada
    Respir Physiol Neurobiol 159:350-9. 2007
    ....
  87. ncbi Survival after pulmonary edema due to enterovirus 71 encephalitis
    M A Nolan
    Division of Neurology, Sydney Children s Hospital, NSW, Australia
    Neurology 60:1651-6. 2003
    A distinctive pattern of enterovirus 71 (EV71) infection, characterized by fever, exanthem, acute pulmonary edema (PE), brainstem encephalitis, and flaccid paresis, affects infants and young children...
  88. ncbi Quantification of lung water by transpulmonary thermodilution in normal and edematous lung
    Enrique Fernandez-Mondejar
    Hospital Universitario Virgen de las Nieves, Granada, Spain
    J Crit Care 18:253-8. 2003
    ..To analyze the accuracy of the transpulmonary thermodilution method in the determination of extravascular lung water (EVLW)...
  89. pmc Role of lung-marginated monocytes in an in vivo mouse model of ventilator-induced lung injury
    Michael R Wilson
    Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea, United Kingdom
    Am J Respir Crit Care Med 179:914-22. 2009
    ..Inflammatory subset Gr-1(high) monocytes are recruited to sites of inflammation and have been implicated in acute lung injury induced by systemic endotoxin...
  90. pmc Defective respiratory amiloride-sensitive sodium transport predisposes to pulmonary oedema and delays its resolution in mice
    Marc Egli
    Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland
    J Physiol 560:857-65. 2004
    ..These data in mice strengthen indirect evidence provided by clinical studies, suggesting that defective respiratory transepithelial sodium transport may also facilitate pulmonary oedema in humans...
  91. ncbi New classification and clinical characteristics of reexpansion pulmonary edema after treatment of spontaneous pneumothorax
    Yun Kwon Kim
    Department of Emergency Medicine, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea
    Am J Emerg Med 27:961-7. 2009
    Reexpansion pulmonary edema (REPE) is a rare yet sometimes fatal complication associated with the treatment of lung diseases such as pleural effusion, pneumothorax, and hemothorax...
  92. ncbi Inflammatory cytokines in BAL fluid and pulmonary hemodynamics in high-altitude pulmonary edema
    K Kubo
    First Department of Internal Medicine, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    Respir Physiol 111:301-10. 1998
    To evaluate the pathogenesis of high-altitude pulmonary edema (HAPE), we performed bronchoalveolar lavage (BAL) and pulmonary hemodynamic studies in seven patients with HAPE at its early stage...
  93. ncbi Endothelial pathomechanisms in acute lung injury
    Nikolaos A Maniatis
    M Simou Laboratory, University of Athens Medical School, Athens, Greece
    Vascul Pharmacol 49:119-33. 2008
    ..and its most severe extreme the acute respiratory distress syndrome (ARDS) refer to increased-permeability pulmonary edema caused by a variety of pulmonary or systemic insults...
  94. ncbi Therapeutic efficacy of milrinone in the management of enterovirus 71-induced pulmonary edema
    Shih Min Wang
    Department of Emergency Medicine, College of Medicine, National Cheng Kung University and Hospital, Tainan, Taiwan
    Pediatr Pulmonol 39:219-23. 2005
    ..Brain-stem encephalitis and pulmonary edema are severe complications that can lead to death...
  95. ncbi Cardiovascular and pulmonary effects of NOS inhibition in endotoxemic conscious rats subjected to swimming training
    Aida Mehanna
    Department of Physiological Sciences, State University of Londrina, Campus Universitario, CEP 86055 900 Londrina, PR, Brazil
    Life Sci 81:1301-8. 2007
    ..induced by LPS, a model of experimental endotoxemia, and to evaluate the role of nitric oxide (NO) in pulmonary edema. Wistar rats were subjected to swimming training (up to 1 h/day, 5 days/week for 4 weeks) after which their ..
  96. ncbi Berberine inhibits cytosolic phospholipase A2 and protects against LPS-induced lung injury and lethality independent of the alpha2-adrenergic receptor in mice
    Hao qing Zhang
    Department of Pathophysiology, Medical College of Jinan University, Guangzhou, Guangdong, China
    Shock 29:617-22. 2008
    ..Here, we report that pretreatment with Ber significantly reduced pulmonary edema, neutrophil infiltration, and histopathological alterations; inhibited protein expression and phosphorylation ..
  97. ncbi Noninvasive ventilation in acute cardiogenic pulmonary edema: systematic review and meta-analysis
    Josep Masip
    ICU Department, Hospital Dos de Maig Consorci Sanitari Integral, University of Barcelona, Barcelona, Spain
    JAMA 294:3124-30. 2005
    In patients with acute cardiogenic pulmonary edema noninvasive ventilation may reduce intubation rate, but the impact on mortality and the superiority of one technique over another have not been clearly established.
  98. ncbi Bedside lung ultrasound in the assessment of alveolar-interstitial syndrome
    Giovanni Volpicelli
    Department of Emergency Medicine, S Luigi Hospital, Orbassano, TO, 10043, Italy
    Am J Emerg Med 24:689-96. 2006
    ....
  99. pmc Alveolar epithelial beta2-adrenergic receptors
    Gokhan M Mutlu
    Northwestern University Feinberg School of Medicine, Pulmonary and Critical Care Medicine, 240 E Huron Street, McGaw M 300, Chicago, IL 60611, USA
    Am J Respir Cell Mol Biol 38:127-34. 2008
    ..agonists to accelerate alveolar fluid clearance in patients with cardiogenic and noncardiogenic pulmonary edema. In this review, we summarize the role of beta(2)-adrenergic receptors in the alveolar epithelium with ..
  100. pmc Clara cell protein (CC16), a marker of lung epithelial injury, is decreased in plasma and pulmonary edema fluid from patients with acute lung injury
    Jonathan A Kropski
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 2650, USA
    Chest 135:1440-7. 2009
    ..We tested the diagnostic and prognostic utility of CC16 in patients with non-trauma-related ALI/ARDS compared to a control group of patients with acute cardiogenic pulmonary edema (CPE).
  101. ncbi "Ultrasound comet-tail images": a marker of pulmonary edema: a comparative study with wedge pressure and extravascular lung water
    Eustachio Agricola
    Division of Non Invasive Cardiology, Cardiothoracic Department, San Raffaele Hospital, Istituto di Richerche e Cura a carattere Scientifico, Milano, Italy
    Chest 127:1690-5. 2005
    Echographic examination of the lung surface may reveal multiple "comet-tail images" originating from water-thickened interlobular septa. These images could be useful for noninvasive assessment of interstitial pulmonary edema.

Research Grants74

  1. REFLEXES IN LEFT VENTRICULAR DYSFUNCTION
    CHULANI KAPPAGODA; Fiscal Year: 2003
    ..Renal functions are also altered. As LVD progresses, PVC evolves into pulmonary edema. This application addresses two issues: (1) the activity of sensory receptors in the lung when the pulmonary ..
  2. Hybrid Katp Channel Opener and Redox Catalyst for Lung Transplantation
    Prakash Jagtap; Fiscal Year: 2013
    ..Recipient rats will be evaluated for a) wet/dy weight ratio (W/D) (a measure of pulmonary edema), b) oxygenation by the graft, c) graft pulmonary vascular resistance, d) dynamic compliance, and e) lung ..
  3. Research Training in Cardiovascular and Pulmonary Diseases
    S Jamal Mustafa; Fiscal Year: 2012
    ..Disease relevance of trainee projects are numerous;eg. coronary ischemia, asthma, pulmonary edema, hypertension, cardiac failure, intestinal vascular inflammation, pulmonary fibrosis, peripheral vascular ..
  4. Repair of Airway Epithelium Following Chlorine Lung Injury
    Gary W Hoyle; Fiscal Year: 2011
    ..respiratory epithelial cell barrier contributes to other sequelae observed in acute lung injury, including pulmonary edema, airway obstruction, inflammation, and respiratory infections...
  5. Mechanisms of endothelial barrier phenotypes in sickle cell disease
    SOLOMON FIIFI OFORI-ACQUAH; Fiscal Year: 2013
    ..In preliminary studies we found increased endothelial permeability and pulmonary edema in two transgenic models of SCD...
  6. Prevention and Treatment of Chlorine Gas Induced Injury to the Pulmonary System
    Sadis Matalon; Fiscal Year: 2011
    ..surfactant function and composition), ability of the lungs to transport ions in vivo and in vitro and clear pulmonary edema in vivo, levels of inflammatory cytokines in the rat alveolar space and in the plasma, arterial blood gases ..
  7. ANDV Induced Responses of Hypoxic Endothelial Cells
    Erich R Mackow; Fiscal Year: 2012
    ..primarily infects endothelial cells (ECs) and HPS is characterized by thrombocytopenia, hypoxia and acute pulmonary edema that leads to respiratory insufficiency...
  8. The Roles of Conserved outer-membrane proteins in SFG rickettsia pathogenesis
    Juan J Martinez; Fiscal Year: 2013
    ..cells especially in the lungs and brain can result in the most severe manifestations of disease including pulmonary edema and interstitial pneumonia...
  9. Mechanisms of ENaC Inhibition by Replicating Influenza Virus: Role of M2 Protein
    Sadis Matalon; Fiscal Year: 2012
    ..region of the viral genome to knockdown M2 expression, and thus broadly and effectively decrease flu induced pulmonary edema and rhinorrhea...
  10. Preventing lethal hemorrhagic fever caused by hantaviruses by preserving endothel
    ALAN L MUELLER; Fiscal Year: 2012
    ..pulmonary syndrome (HPS) which is characterized by fever and vascular leakage resulting in noncardiogenic pulmonary edema followed in severe cases by shock and death2...
  11. Heme Oxygenase-1 in Lung Ischemia-Reperfusion Injury
    Patty J Lee; Fiscal Year: 2012
    ..lung injury during lung transplantation/surgery, thromboembolectomy, pulmonary embolism, and re-expansion pulmonary edema, all of which lead to clinically significant respiratory failure but for which no specific therapies exist...
  12. (INTRODUCTION) MECHANISMS OF ACCLIMATIZATION: FETUS AND ADULT
    Lawrence D Longo; Fiscal Year: 2013
    ..mechanisms of diseases, including: Acute Mountain Sickness, Preeclampsia, and High Altitude Cerebral and Pulmonary Edema. PUBLIC HEALTH RELEVANCE: Scientifically, the studies will augment our understanding of basic mechanisms ..
  13. Advancing a Lead Candidate Hantavirus Pulmonary Syndrome DNA Vaccine
    JAY WILLIAMS HOOPER; Fiscal Year: 2013
    ..resembles HPS in humans including: incubation time, rapid onset/progression, target tissue (endothelium), pulmonary edema, pleural effusion, and shock...
  14. Tie2 Activation for the Treatment of Chemical-Induced Acute Lung Injury
    Christopher D Kontos; Fiscal Year: 2013
    ..Exposure to phosgene gas causes acute lung injury (ALI) that primarily targets alveoli, resulting in acute pulmonary edema and fatal acute respiratory distress syndrome...
  15. TRAFFIC REGULATORY PROTEINS AND ENAC
    Raymond A Frizzell; Fiscal Year: 2013
    ..function are implicated in significant human diseases, including hypertension, nephrosis, cystic fibrosis and pulmonary edema. In renal and airway epithelia, ENaC activity is regulated by factors that control the number of active ..
  16. Alcohol increases tight junction permeability &disrupts translocation of ZO-1
    Samantha Simet; Fiscal Year: 2012
    ..In the lung this occurs in the parenchyma compartment resulting in pulmonary edema and alveolar edema...
  17. Intrauterine chronic hypoxia and ryanodine receptors in fetal pulmonary arteries
    Sean M Wilson; Fiscal Year: 2013
    ..and smoking puts infants of certain populations at risk o developing pulmonary hypertension, high altitude pulmonary edema, and increases the risk for development of idiopathic pulmonary hypertension later in life...
  18. Microtubule-associated Rac
    Anna Birukova; Fiscal Year: 2013
    ..Compromised lung endothelial cell (EC) permeability leads to pulmonary edema, a serious complication observed in various lung diseases and associated with high mortality...
  19. Countermeasures for chlorine-induced airway fibrosis
    Gary W Hoyle; Fiscal Year: 2013
    ..Acute effects of chlorine inhalation include dyspnea, hypoxemia, pneumonitis, and pulmonary edema. Longer term consequences of chlorine inhalation include pulmonary function impairment and airway structural ..
  20. Control of lung permeability by oxidized phospholipids
    Konstantin Birukov; Fiscal Year: 2012
    ..of the blood-gas barrier, which allows an influx of protein-rich fluid into the air spaces, causing pulmonary edema. However, despite recent advances in ventilation strategies and a better understanding of the pathophysiology ..
  21. The Role of HMGB1 in Acute Lung Injury-Induced Endothelial Cell Permeability
    Rachel K Wolfson; Fiscal Year: 2012
    ..Acute lung injury (All) results from loss of the alveolar-capillary barrier with high-permeability pulmonary edema and alveolar flooding...
  22. A Novel Device for Managing Hypervolemia in CHF Patients
    Mohamed E Labib; Fiscal Year: 2011
    ..excess, repetitive hospitalizations commonly incurred by dialysis patients who suffer from fluid overload and pulmonary edema. Reducing the number of these emergency hospitalizations would undoubtedly be a major cost savings for the ..
  23. Protective role of ANP in the models of acute lung injury
    Anna Birukova; Fiscal Year: 2013
    ..injury are life-threatening conditions associated with lung vascular barrier dysfunction, which may lead to pulmonary edema. Increased levels of atrial natriuretic peptide (ANP) in lung circulation reported in these pathologies ..
  24. Functional Genomics of Chemical-Induced Acute Lung Injury
    GEORGE DOUGLAS LEIKAUF; Fiscal Year: 2013
    ..effort, much remains to be understood regarding pathological events linking Inhalation exposures to delayed pulmonary edema, respiratory failure, and ultimately death...
  25. Slit2N for the Treatment of Viral Hemorrhagic Fever
    ALAN L MUELLER; Fiscal Year: 2012
    ..shock syndrome (DSS) which are characterized by fever and vascular leakage resulting in non-cardiogenic pulmonary edema followed in severe cases by shock and death1. Navigen's scientific co-founder, Dr...
  26. Mesenchymal Stem Cells for Treatment of Acute Lung Injury
    Jae Woo Lee; Fiscal Year: 2012
    ..interface that are injured by cytomix, a mixture of the most biologically active cytokines found in ALI pulmonary edema fluid (IL-1f3, TNFa and IFNv)...
  27. Protein kinase B (Akt)-mediated pathway regulating endothelial-barrier function
    SOMANATH P RAMMOHAN SHENOY; Fiscal Year: 2013
    ..often lead to irreversible VP, which is an underlying cause of many clinical conditions such as stroke, pulmonary edema, inflammation, atherosclerosis etc...
  28. Imaging Nonlinear Control of the Pulmonary Circulation with Proton MRI
    Susan R Hopkins; Fiscal Year: 2013
    ..subjects and those with a known abnormality of the pulmonary circulation-previous sufferers of high altitude pulmonary edema (HAPE). In HAPE a previously healthy individual, develops a florid pulmonary edema at altitude...
  29. Synthetic surfactant and toxic chemical lung injury
    Frans J Walther; Fiscal Year: 2011
    ..applicant): The major physiologic actions of inhaled toxic chemicals on the lung are bronchoconstriction and pulmonary edema. Although these effects are well understood, the absence of specific antidotes has limited the effectiveness ..
  30. Cardiac Imaging of Thoracic Fat and Aortic Stiffness in Older High Risk Patients
    Tina E Brinkley; Fiscal Year: 2013
    ..Research: The proposed research will be an ancillary study to the Vascular Stiffness and Pulmonary Edema Study, a prospective study examining the association between dobutamine stress-induced changes in aortic ..
  31. CARDIOPROTECTIVE EFFECTS OF PDE-5 INHIBITORS
    Rakesh C Kukreja; Fiscal Year: 2013
    ..and cardiomyocytes against myocardial infarction, apoptosis, contractile dysfunction, cardiac hypertrophy, pulmonary edema following I/R injury...
  32. Microthrombus Formation Triggers Lung Injury in Sepsis
    BRUCE ALLAN HARMS; Fiscal Year: 2012
    ..VA data show that approximately 10,000 patients are stricken annually with ARDS, respiratory failure, and pulmonary edema throughout the VA system. These are conditions that are frequently caused by sepsis-associated lung injury...
  33. MAP Kinase Signaling in Apoptosis-Induced Ventilator-Associated Lung Injury
    Mahendra Damarla; Fiscal Year: 2013
    ..phosphorylation of HSP25 (HSP27's murine homologue) correlates with HVT MV mediated apoptosis and pulmonary edema. However, the specific mechanism(s) by which MK2 or HSP25 contribute to the development of VALI are unknown...
  34. Mechanisms of PMN and Endothelial-Mediated Lung Inflammation and Injury
    Asrar B Malik; Fiscal Year: 2013
    ..PMN) and endothelial activation that induce lung inflammation and vascular injury and lead to protein-rich pulmonary edema and acute lung injury (ALI) and specific mechanisms that lead to recovery...
  35. Role of cGMP in Ventilator-Induced Lung Endothelial Barrier Dysfunction
    David B Pearse; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Failure of the lung endothelial barrier leads to pulmonary edema and acute lung injury (ALI)...
  36. Protein Therapy for Acute Lung Injury
    Jahar Bhattacharya; Fiscal Year: 2010
    ..The main pathology in ALI is attributed to pulmonary edema, a direct result of endothelial (EC) barrier deterioration in the lung...
  37. Genes contributing to patent ductus arteriosus susceptibility in preterm newborns
    Ronald I Clyman; Fiscal Year: 2013
    ..causes altered mesenteric, renal and cerebral blood flows, impairs pulmonary mechanics, increases the risk of pulmonary edema and hemorrhage, and prolongs the need for mechanical ventilation in preterm infants...
  38. cAMP Phosphodiesterase and Lung Endothelial Cell Permeability
    Thomas C Rich; Fiscal Year: 2010
    ..Disruption of the pulmonary endothelial barrier results in pulmonary edema as fluid accumulates in the interstitium and ultimately in the distal airspaces...
  39. Effects of Hypoxia on Alveolar Epithelial Cytoskeleton
    Karen M Ridge; Fiscal Year: 2013
    ..For example, alveolar hypoxia may be the consequence of obstructive airway diseases, or pulmonary edema from heart failure or acute lung injury...
  40. RESOLUTION OF CLINICAL LUNG INJURY
    Michael A Matthay; Fiscal Year: 2013
    ..In Aim 1, we will use pulmonary edema fluid and plasma from critically ill patients with acute lung injury to study the mechanisms that mediate an ..
  41. Effect of Resveratrol on Staphylococcal Enterotoxin B induced Vascular Leak
    SADIYE AMCAOGLU RIEDER; Fiscal Year: 2010
    ..In some cases, ALI further develops into acute lung distress syndrome (ARDS), and because this leads to pulmonary edema and dysfunction, this syndrome is often lethal...
  42. COMPARE Study: electroCardiographic evaluatiOn of ischeMia comParing invAsive to
    Michele M Pelter; Fiscal Year: 2011
    ..Outcomes (arrhythmias requiring intervention, hemodynamic compromise, pulmonary edema, unplanned transfer to intensive care, death, and infarction) will be assessed at hospital discharge...
  43. Regulation of alveolar epithelial homeostasis in acute lung injury
    Jieru Wang; Fiscal Year: 2013
    ..cells and causes more severe disease than seasonal influenza virus, including diffuse alveolar damage and pulmonary edema. To define the mechanism of this tissue injury, it is important to study the specific cells that are infected ..
  44. Lung Fluid Balance and Mesenchymal Stem Cells
    Michael A Matthay; Fiscal Year: 2012
    ..Aim 1 is designed to determine the therapeutic effects of intrapulmonary and intravenous delivery of MSC on pulmonary edema and survival in clinically relevant mouse models of acute lung injury...
  45. Electroporation-mediated Pulmonary Gene Transfer for Acute Lung Injury
    David A Dean; Fiscal Year: 2012
    ..We have shown that electroporation can be used to transfer genes to lungs with established lung injury and pulmonary edema to treat the disease and lessen the severity of the injury. The method is simple, fast, and safe...
  46. Role of the Na K ATPase Beta 1 subunit in alveolar epithelial integrity
    Olga Vagin; Fiscal Year: 2013
    ..chaperone-assisted maturation of the Na,K- ATPase in alveolar epithelial cells and finding the means to prevent ER retention of the enzyme during hypoxia may lead to more effective treatment for pulmonary edema and acute lung injury.
  47. Tissue Factor Antagonists for ALI/ARDS
    Hing C Wong; Fiscal Year: 2013
    ..elevated levels of TF observed in plasma of ALI/ARDS patients compared to control patients with hydrostatic pulmonary edema. These higher plasma TF levels correlated with increased mortality, fewer ventilator-free days, the presence ..
  48. Treatment of Pulmonary Edema in Organ Donors
    Lorraine B Ware; Fiscal Year: 2012
    ..Since pulmonary edema is a common, reversible cause of pulmonary infiltrates and hypoxemia in patients with brain injury, ..
  49. The injurious effects of hypercapnia on the alveolar epithelium
    Jacob I Sznajder; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Patients with pulmonary edema and acute respiratory distress syndrome (ARDS) are often exposed to hypercapnia (high CO2 levels in the blood)..
  50. Mechanisms of acute lung injury from blood transfusions.
    MARK ROBERTS LOONEY; Fiscal Year: 2013
    ..and platelets are both required to produce acute lung endothelial injury, protein permeability, and pulmonary edema. However, the mechanisms by which neutrophils and platelets potentially interact and ultimately lead to lung ..
  51. Hypoxia Disrupts the Alveolar Barrier: Role of Claudins
    ALEJANDRO PIERRE COMELLAS; Fiscal Year: 2010
    ..During lung injury and pulmonary edema a hypoxic environment is present at the alveolus which could contribute to further disruption of the alveolar ..
  52. Aging effects on acute lung inflammation after burn injury
    Vanessa Nomellini; Fiscal Year: 2010
    ..young and aged mice after receiving a burn injury by examining 1) the number of neutrophils, 2) the degree of pulmonary edema, and 3) changes in the alveolar barrier function in lungs of mice from each age group...
  53. Air/liquid interface cultures for alveolar type II cell differentiation
    ROBERT JAMES MASON; Fiscal Year: 2012
    ..This study should also indicate that sustained pulmonary edema will impair type I cell function and provide another reason for the use of supplemental oxygen in acute lung ..
  54. THROMBIN-INDUCED PULMONARY VASCULAR PERMEABILITY
    Asrar B Malik; Fiscal Year: 2012
    ..of the AJ complex and its interacting proteins that will prevent vascular leakiness and formation of pulmonary edema. PUBLIC HEALTH RELEVANCE: The cellular and molecular mechanisms responsible for increased permeability of the ..
  55. INTERFACIAL ADSORPTION OF PULMONARY SURFACTANT
    Stephen B Hall; Fiscal Year: 2010
    ..The injury leads to pulmonary edema and respiratory failure...
  56. Therapeutic Interventions Against ANDV Induced Pathogenesis
    Erich R Mackow; Fiscal Year: 2013
    ..Andes virus (ANDV) infection results in acute pulmonary edema and respiratory insufficiency termed hantavirus pulmonary syndrome (HPS)...
  57. MICROPUNCTURE STUDIES OF LUNG WATER AND SOLUTE EXCHANGE
    Jahar Bhattacharya; Fiscal Year: 2012
    ..microvascular barrier properties by activating the protein, focal adhesion kinase (FAK), thereby blocking pulmonary edema in acute lung injury (ALI)...
  58. TLR2 in Sepsis-Induced Coagulopathy, Endothelial Leak, and Pulmonary Dysfunction
    Judith Hellman; Fiscal Year: 2010
    ..Histologic analyses will assess for microvascular thrombosis, architectural changes, evidence of pulmonary edema, and lung expression of PAI-1 and TF.
  59. Host Vascular Mechanism for Therapeutic Protection against Select Pathogens
    Joanne Chan; Fiscal Year: 2013
    ..This leads to pulmonary edema and respiratory problems, hemorrhagic fever or shock-like symptoms...
  60. Disintegrin Metalloprotease and Endothelial Permeability
    Sarah Y Yuan; Fiscal Year: 2013
    ..in the lungs during bacterial infection or septic stimulation, contributing to neutrophil infiltration and pulmonary edema. The tissue-specific effect and underlying mechanisms of ADAM15-mediated barrier injury have not been ..
  61. Comprehensive Characterization of Intrapulmonary Arteriovenous Pathways in Health
    Marlowe Eldridge; Fiscal Year: 2012
    ..of inducible intrapulmonary shunt pathways in health, bronchopulmonary dysplasia (BPD) and high altitude pulmonary edema (HAPE)...
  62. Pulmonary Limitations in Chronic Heart Failure
    Bruce D Johnson; Fiscal Year: 2013
    ..resting measures of cardiac function and may provide insight into optimization of therapy, 3) development of pulmonary edema (component of pulmonary congestion) is not tightly linked to the degree of cardiac dysfunction resulting in ..
  63. Hypoxia-induced Endothelial Barrier Dysfunction
    Usamah Kayyali; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Non-cardiac pulmonary edema is a frequent affliction in pulmonary medicine and is caused by endothelial barrier dysfunction...
  64. LUNG FUNCTION IN PROLONGED HEART FAILURE
    Marie Francoise Doursout; Fiscal Year: 2004
    DESCRIPTION (Applicant's abstract): Pulmonary edema (too much fluid in the lungs) is one of the most common and serious complications of heart failure...
  65. NEUROGENIC INFLUENCES ON LUNG FLUID AND SOLUTE EXCHANGE
    Fred Minnear; Fiscal Year: 1990
    ..changes and acute pulmonary vascular hypertension have been postulated as mechanisms in the development of pulmonary edema after a variety of clinical syndromes such as subarachnoid hemorrhage, intracranial hypertension, cerebral ..
  66. Lung Perfusion Heterogeneity and Mechanisms of Edema
    Susan R Hopkins; Fiscal Year: 2010
    ..of pulmonary blood flow and increased pulmonary capillary pressures interact to affect the development of pulmonary edema. High altitude pulmonary edema (HAPE), an acute potentially fatal edema is used as a disease model, to allow ..
  67. ADVERSE EVENTS WITH MAGNESIUM SULFATE
    George Macones; Fiscal Year: 2000
    ..While MgSO4 is felt to have a tolerable side-effect profile, there is a risk of pulmonary edema (the most dangerous adverse event) with its use with estimates as high as 8%...
  68. INTEGRIN AVB3 SIGNALLING IN LUNG ENDOTHELIUM
    Sunita Bhattacharya; Fiscal Year: 1999
    ..objective is to understand mechanisms controlling lung endothelial permeability that may predispose to pulmonary edema. Previous work indicates ligation of the alpha(v)beta(3) integrin receptor on lung endothelium by the ..
  69. MECHANISMS OF FLUID BALANCE IN LOWER VERTEBRATE LUNGS
    ALLAN SMITS; Fiscal Year: 1991
    ..applicant's abstract) One of the most life-threatening clinical conditions in respiratory medicine today is pulmonary edema, in which an accumulation of fluid in the lung tissue greatly impedes the diffusion of oxygen and carbon ..
  70. LV DYSFUNCTION WITH MASSIVE SYMPATHETIC ACTIVITY
    CHARLES PILATI; Fiscal Year: 1993
    ..central nervous system (CNS) often intensely activates the sympathetic nervous system (SNS), and neurogenic pulmonary edema (NPE) frequently results...
  71. Caveolin-1 and NO Regulate PMN-mediated Increases in Vascular Permeability
    Richard D Minshall; Fiscal Year: 2011
    ..of polymorphonuclear leukocytes (PMNs) adherent to endothelial cells via ICAM-1 leads to protein-rich pulmonary edema formation and acute lung injury...
  72. ONCOTIC PRESSURE AND EXTRAVASCULAR LUNG WATER IN ARDS
    Gregory Martin; Fiscal Year: 2004
    ..ARDS is defined by acute impairment of oxygenation and radiographic infiltrates compatible with pulmonary edema without increased hydrostatic pressures...
  73. BRONCHIAL CIRCULATION AND LUNG FLUID BALANCE
    George Kramer; Fiscal Year: 1993
    ..The above observations suggest the following hypothesis: The development of pulmonary edema during inflammatory lung disease results in part from the highly reactive bronchial circulation...
  74. Vascular endothelial growth factor induced lung edema
    Robert Kaner; Fiscal Year: 2004
    ..One of the earliest manifestations of ARDS is the development of noncardiogenic pulmonary edema. We have made the novel observation that pulmonary edema is induced by overexpression of the vascular ..