pulmonary edema

Summary

Top Publications

  1. doi Swimming-induced pulmonary edema in triathletes
    Charles C Miller
    Department of Biomedical Sciences, Texas Tech University Health Sciences Center at El Paso Paul L Foster School of Medicine, El Paso, TX 79905, USA
    Am J Emerg Med 28:941-6. 2010
  2. ncbi Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles of cytokines and cellular immune activation in patients with pulmonary edema
    Shih Min Wang
    Department of Emergency Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
    J Infect Dis 188:564-70. 2003
  3. pmc Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema
    Carole A Oskeritzian
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    J Exp Med 207:465-74. 2010
  4. ncbi Lung epithelial fluid transport and the resolution of pulmonary edema
    Michael A Matthay
    Cardiovascular Research Institute and Department of Medicine, University of California, San Francisco, California 94143 0624, USA
    Physiol Rev 82:569-600. 2002
  5. ncbi Lung overexpression of the vascular endothelial growth factor gene induces pulmonary edema
    R J Kaner
    Division of Pulmonary and Critical Care Medicine and Weill Medical College of Cornell University, New York, New York, USA
    Am J Respir Cell Mol Biol 22:657-64. 2000
  6. doi Extravascular lung water indexed to predicted body weight is a novel predictor of intensive care unit mortality in patients with acute lung injury
    Thelma R Craig
    Regional Intensive Care Unit, Royal Victoria Hospital, Belfast, UK
    Crit Care Med 38:114-20. 2010
  7. pmc Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells
    Mohammad Tauseef
    Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Circ Res 103:1164-72. 2008
  8. ncbi High-altitude pulmonary edema
    Norbert F Voelkel
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    N Engl J Med 346:1606-7. 2002
  9. doi Predictors of the first heart failure hospitalization in patients who are stable survivors of myocardial infarction complicated by pulmonary congestion and/or left ventricular dysfunction: a VALIANT study
    Eldrin F Lewis
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Eur Heart J 29:748-56. 2008
  10. ncbi Modulation of cytokine production by intravenous immunoglobulin in patients with enterovirus 71-associated brainstem encephalitis
    Shih Min Wang
    Department of Emergency Medicine, National Cheng Kung University and Hospital, 138 Sheng Li Road, 70428 Tainan, Taiwan
    J Clin Virol 37:47-52. 2006

Research Grants

  1. REFLEXES IN LEFT VENTRICULAR DYSFUNCTION
    CHULANI KAPPAGODA; Fiscal Year: 2003
  2. Lung Perfusion Heterogeneity and Mechanisms of Edema
    Susan Hopkins; Fiscal Year: 2007
  3. Lung Fluid Balance and Mesenchymal Stem Cells
    Michael Matthay; Fiscal Year: 2009
  4. Repair of Airway Epithelium Following Chlorine Lung Injury
    Gary W Hoyle; Fiscal Year: 2010
  5. REFLEXES IN LEFT VENTRICULAR DYSFUNCTION
    CHULANI KAPPAGODA; Fiscal Year: 2002
  6. REFLEXES IN LEFT VENTRICULAR DYSFUNCTION
    CHULANI KAPPAGODA; Fiscal Year: 2000
  7. REFLEXES IN LEFT VENTRICULAR DYSFUNCTION
    CHULANI KAPPAGODA; Fiscal Year: 2001
  8. CNS PROCESSING OF BRONCHOPULMONARY FIBER AFFERENT INPUT
    Ann Bonham; Fiscal Year: 1992
  9. LUNG FUNCTION IN PROLONGED HEART FAILURE
    Marie Francoise Doursout; Fiscal Year: 2004
  10. LUNG FUNCTION IN PROLONGED HEART FAILURE
    Marie Francoise Doursout; Fiscal Year: 2003

Detail Information

Publications336 found, 100 shown here

  1. doi Swimming-induced pulmonary edema in triathletes
    Charles C Miller
    Department of Biomedical Sciences, Texas Tech University Health Sciences Center at El Paso Paul L Foster School of Medicine, El Paso, TX 79905, USA
    Am J Emerg Med 28:941-6. 2010
    b>Pulmonary edema related to water immersion has been reported in military trainees and scuba and breath-hold divers, but rarely in the community. To date, no risk factors for this phenomenon have been identified by epidemiological methods...
  2. ncbi Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles of cytokines and cellular immune activation in patients with pulmonary edema
    Shih Min Wang
    Department of Emergency Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
    J Infect Dis 188:564-70. 2003
    ..epidemics of enterovirus 71 (EV71) infections, which were associated with brainstem encephalitis (BE) and pulmonary edema (PE)...
  3. pmc Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema
    Carole A Oskeritzian
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    J Exp Med 207:465-74. 2010
    ..E-triggered anaphylactic responses, including elevation of circulating histamine and associated pulmonary edema in mice, were significantly attenuated by the S1P(2) antagonist JTE-013 and in S1P(2)-deficient mice, in ..
  4. ncbi Lung epithelial fluid transport and the resolution of pulmonary edema
    Michael A Matthay
    Cardiovascular Research Institute and Department of Medicine, University of California, San Francisco, California 94143 0624, USA
    Physiol Rev 82:569-600. 2002
    ..at the time of birth as well as in the mature lung when pathological conditions lead to the development of pulmonary edema. Currently, the best described molecular transporters are the epithelial sodium channel, the cystic fibrosis ..
  5. ncbi Lung overexpression of the vascular endothelial growth factor gene induces pulmonary edema
    R J Kaner
    Division of Pulmonary and Critical Care Medicine and Weill Medical College of Cornell University, New York, New York, USA
    Am J Respir Cell Mol Biol 22:657-64. 2000
    ..an identical adenovirus vector with an irrelevant transgene had no effect upon subsequent AdVEGF165-induced pulmonary edema. Together, these data suggest that overexpression of VEGF in the lung may be one mechanism of increased ..
  6. doi Extravascular lung water indexed to predicted body weight is a novel predictor of intensive care unit mortality in patients with acute lung injury
    Thelma R Craig
    Regional Intensive Care Unit, Royal Victoria Hospital, Belfast, UK
    Crit Care Med 38:114-20. 2010
    Acute lung injury and the acute respiratory distress syndrome are characterized by noncardiogenic pulmonary edema, which can be assessed by measurement of extravascular lung water...
  7. pmc Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells
    Mohammad Tauseef
    Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Circ Res 103:1164-72. 2008
    ..In contrast to wild-type mice, Sphk1(-/-) mice showed markedly enhanced pulmonary edema formation in response to lipopolysaccharide and PAR-1 activation...
  8. ncbi High-altitude pulmonary edema
    Norbert F Voelkel
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    N Engl J Med 346:1606-7. 2002
  9. doi Predictors of the first heart failure hospitalization in patients who are stable survivors of myocardial infarction complicated by pulmonary congestion and/or left ventricular dysfunction: a VALIANT study
    Eldrin F Lewis
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Eur Heart J 29:748-56. 2008
    ..We sought to assess the incidence of and prognostic factors for heart failure (HF) hospitalization among survivors of high-risk acute myocardial infarction (MI)...
  10. ncbi Modulation of cytokine production by intravenous immunoglobulin in patients with enterovirus 71-associated brainstem encephalitis
    Shih Min Wang
    Department of Emergency Medicine, National Cheng Kung University and Hospital, 138 Sheng Li Road, 70428 Tainan, Taiwan
    J Clin Virol 37:47-52. 2006
    ..Several epidemics of enterovirus 71 (EV71) infections occurred in Taiwan since 1998...
  11. ncbi Role of oxidative stress and NFkB in hypoxia-induced pulmonary edema
    Sagi Sarada
    Department of Experimental Biology, Defense Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi 54, India
    Exp Biol Med (Maywood) 233:1088-98. 2008
    ..increased oxidative stress further upregulates the nuclear transcription factor (NFkB) in the development of pulmonary edema. The rats were exposed to hypobaric hypoxia at 7620 m (280 mm Hg) for different durations, that is, 3 hrs, 6 ..
  12. ncbi The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome
    J Pugin
    Department of Internal Medicine, University Hospital of Geneva, Switzerland
    Crit Care Med 27:304-12. 1999
    ..the concentrations of proinflammatory mediators, collagenases, and procollagen type III peptides in undiluted pulmonary edema fluids and in plasma obtained in patients with early acute respiratory distress syndrome (ARDS) and in ..
  13. ncbi Saturated hydrogen saline protects the lung against oxygen toxicity
    Juan Zheng
    Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China
    Undersea Hyperb Med 37:185-92. 2010
    ..These results demonstrated that saturated hydrogen saline alleviated hyperoxia-induced pulmonary injury, which was partly responsible for the inhibition of oxidative damage...
  14. ncbi Hypoxia impairs systemic endothelial function in individuals prone to high-altitude pulmonary edema
    Marc M Berger
    Department of Internal Medicine VI Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Germany
    Am J Respir Crit Care Med 172:763-7. 2005
    High-altitude pulmonary edema (HAPE) is characterized by excessive pulmonary vasoconstriction and is associated with decreased concentrations of nitric oxide (NO) in the lung...
  15. ncbi Pathophysiology of acute lung injury and the acute respiratory distress syndrome
    Lorraine B Ware
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Semin Respir Crit Care Med 27:337-49. 2006
    ..Future therapies aimed at restoring the overall balance of cytokines, oxidants, coagulants, and proteases may ultimately be successful where therapies that target individual cytokines or other mediators have not...
  16. pmc Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management
    Michael A Matthay
    Department of Medicine, Cardiovascular Research and Training Institute, University of California at San Francisco, San Francisco, California 94143 0130, USA
    Am J Respir Cell Mol Biol 33:319-27. 2005
  17. pmc Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung
    Jae W Lee
    Department of Anesthesiology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:16357-62. 2009
    ..coli endotoxin. Intra-bronchial instillation of endotoxin into the distal airspaces resulted in pulmonary edema with the loss of alveolar epithelial fluid transport measured as alveolar fluid clearance...
  18. ncbi Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury
    Daniel F McAuley
    Cardiovascular Research Institute, University of California, San Francisco, CA, USA
    Crit Care Med 32:1470-6. 2004
    ..clinically relevant airspace concentrations of beta2-adrenergic agonists stimulated maximal alveolar fluid clearance rates and to determine whether beta2 agonist therapy decreased pulmonary edema in experimental acute lung injury.
  19. ncbi Reexpansion pulmonary edema
    Yasunori Sohara
    Department of Surgery, Faculty of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Ann Thorac Cardiovasc Surg 14:205-9. 2008
    When a rapidly reexpanding lung has been in a state of collapse for more than several days, pulmonary edema sometimes occurs in it. This is called reexpansion pulmonary edema (RPE)...
  20. pmc Alveolar edema fluid clearance and acute lung injury
    Yves Berthiaume
    Département de médecine et Centre de recherche du Centre Hospitalier de l Université de Montréal, Universite de Montreal, Montreal, Quebec, Canada
    Respir Physiol Neurobiol 159:350-9. 2007
    ....
  21. doi Endothelial pathomechanisms in acute lung injury
    Nikolaos A Maniatis
    M Simou Laboratory, University of Athens Medical School, Athens, Greece
    Vascul Pharmacol 49:119-33. 2008
    ..and its most severe extreme the acute respiratory distress syndrome (ARDS) refer to increased-permeability pulmonary edema caused by a variety of pulmonary or systemic insults...
  22. ncbi Usefulness of ultrasound lung comets as a nonradiologic sign of extravascular lung water
    Zoltan Jambrik
    Institute of Clinical Physiology, CNR Lab, Via Moruzzi 1, 56123 Pisa, Italy
    Am J Cardiol 93:1265-70. 2004
    ....
  23. doi Streptococcal M1 protein-provoked CXC chemokine formation, neutrophil recruitment and lung damage are regulated by Rho-kinase signaling
    Songen Zhang
    Department of Clinical Sciences, Section for Surgery, Malmo University Hospital, Lund University, Malmo, Sweden
    J Innate Immun 4:399-408. 2012
    ....
  24. doi Hypoxic preconditioning with cobalt ameliorates hypobaric hypoxia induced pulmonary edema in rat
    Dhananjay Shukla
    Defence Institute of Physiology and Allied Sciences DIPAS, Lucknow Road, Timarpur, Delhi 110054, India
    Eur J Pharmacol 656:101-9. 2011
    ..considered as an acute physiological stress and often leads to high altitude maladies such as high altitude pulmonary edema (HAPE) and high altitude cerebral edema (HACE)...
  25. ncbi Protein kinase C modulates pulmonary endothelial permeability: a paradigm for acute lung injury
    Alma Siflinger-Birnboim
    Research Service, Stratton Veterans Affairs Medical Center and the Center for Cardiovascular Science, The Albany Medical College, Albany, New York 12208, USA
    Am J Physiol Lung Cell Mol Physiol 284:L435-51. 2003
    The intracellular serine/threonine kinase protein kinase C (PKC) has an important role in the genesis of pulmonary edema. This review discusses the PKC-mediated mechanisms that participate in the pulmonary endothelial response to agents ..
  26. pmc Postobstructive pulmonary edema: a case for hydrostatic mechanisms
    Richard D Fremont
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, T1218 MCN, 1161 Twenty First Ave S, Nashville, TN 37232 2650, USA
    Chest 131:1742-6. 2007
    Postobstructive pulmonary edema is a well-recognized complication of upper airway obstruction...
  27. doi Neurogenic pulmonary edema in a fatal case of subarachnoid hemorrhage
    Jorg Ahrens
    Department of Anesthesiology, Hannover Medical School, D 30625 Hannover, Germany
    J Clin Anesth 20:129-32. 2008
    Neurogenic pulmonary edema (NPE) is caused by a variety of central nervous system lesions and may appear as a subclinical complication. The fulminant form of NPE is always life-threatening...
  28. ncbi Cardiac output increases prior to development of pulmonary edema after re-expansion of spontaneous pneumothorax
    H C Tan
    Division of Cardiology, Changi General Hospital, Singapore
    Respir Med 96:461-5. 2002
    b>Pulmonary edema following reexpansion of spontaneous pneumothorax is an uncommon complication. The underlying mechanism of this condition is unclear...
  29. pmc Negative pressure pulmonary edema after oral and maxillofacial surgery
    Hideki Mamiya
    Department of Dental Anesthesiology, Tokyo Dental College, Chiba, Japan
    Anesth Prog 56:49-52. 2009
    Negative pressure pulmonary edema (NPPE) following upper airway obstruction (UAO) has been reported in several clinical situations. The main cause of NPPE is reported to be increased negative intrathoracic pressure...
  30. ncbi Assessment of acute pulmonary edema in dogs by electrical impedance imaging
    J C Newell
    Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Ttoy, NY 12180, USA
    IEEE Trans Biomed Eng 43:133-8. 1996
    Acute pulmonary edema was assessed quantitatively in 12 experiments on six anesthetized dogs. Thirty-two copper foil electrodes were placed around each animal's thorax at the level of the third intercostal space...
  31. ncbi Negative pressure pulmonary edema--five case reports
    Islam Massad
    Department of Anaesthesia and Intensive Care, Jordan University Hospital, Amman, Jordan
    Middle East J Anesthesiol 18:977-84. 2006
  32. doi Update on high-altitude pulmonary edema: pathogenesis, prevention, and treatment
    Joshua O Stream
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA
    Wilderness Environ Med 19:293-303. 2008
    High-altitude pulmonary edema (HAPE) is a life-threatening noncardiogenic form of pulmonary edema (PE) that afflicts susceptible persons after rapid ascent to high altitude above 2500 m...
  33. pmc Chest sonography: a useful tool to differentiate acute cardiogenic pulmonary edema from acute respiratory distress syndrome
    Roberto Copetti
    Emergency Department S, Antonio Abate General Hospital, Tolmezzo, Italy
    Cardiovasc Ultrasound 6:16. 2008
    Differential diagnosis between acute cardiogenic pulmonary edema (APE) and acute lung injury/acute respiratory distress syndrome (ALI/ARDS) may often be difficult...
  34. ncbi Exercise-induced pulmonary edema in heart failure
    Piergiuseppe Agostoni
    Centro Cardiologico Monzino, IRCCS, Istituto di Cardiologia, Universita di Milano, Via Parea 4, 20138 Milan, Italy
    Circulation 108:2666-71. 2003
    ..failure (HF) patients, exercise may increase pulmonary capillary hydrostatic pressure and thereby generate pulmonary edema. If pulmonary edema developed, alveolar-capillary membrane conductance (Dm), measured immediately after ..
  35. ncbi Chest ultrasonography for the diagnosis and monitoring of high-altitude pulmonary edema
    Peter J Fagenholz
    MFA, Department of Emergency Medicine, Clinics 115, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02140, USA
    Chest 131:1013-8. 2007
    The comet-tail technique of chest ultrasonography has been described for the diagnosis of cardiogenic pulmonary edema. This is the first report describing its use for the diagnosis and monitoring of high-altitude pulmonary edema (HAPE), ..
  36. pmc Boussignac continuous positive airway pressure for the management of acute cardiogenic pulmonary edema: prospective study with a retrospective control group
    Willem Dieperink
    Thoraxcenter, Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1 P O Box 30, 001, 9700 RB Groningen, The Netherlands
    BMC Cardiovasc Disord 7:40. 2007
    Continuous positive airway pressure (CPAP) treatment for acute cardiogenic pulmonary edema can have important benefits in acute cardiac care...
  37. ncbi Negative pressure pulmonary hemorrhage
    D R Schwartz
    Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston 02114 2696, USA
    Chest 115:1194-7. 1999
    Negative pressure pulmonary edema, a well-recognized phenomenon, is the formation of pulmonary edema following an acute upper airway obstruction (UAO)...
  38. ncbi Neurogenic pulmonary edema during intracranial endovascular therapy
    Randall P Brewer
    Department of Anesthesiology, Duke University School of Medicine, Durham, NC, USA
    Neurocrit Care 1:423-7. 2004
    Neurogenic pulmonary edema (NPE) is a well-known complication of acute brain injury. Neurogenic stunned myocardium (NSM) occurs clinically in a significant subset of patients with NPE...
  39. ncbi Non-invasive pressure support ventilation versus conventional oxygen therapy in acute cardiogenic pulmonary oedema: a randomised trial
    J Masip
    Cardiology Department, Consorci Sanitari Creu Roja de Catalunya, Hospital Creu Roja de Barcelona, University of Barcelona, Spain
    Lancet 356:2126-32. 2000
    ..We assessed the efficacy of this therapy in acute cardiogenic pulmonary oedema in a randomised comparison with conventional oxygen therapy...
  40. ncbi Platelet count and function at high altitude and in high-altitude pulmonary edema
    T Lehmann
    Dept of Internal Medicine, Kantonsspital, CH 7000 Chur, Switzerland
    J Appl Physiol 100:690-4. 2006
    ..exposure on platelet function as part of a larger study on 30 subjects with a history of high-altitude pulmonary edema (HAPE) and 10 healthy controls...
  41. ncbi Pathogenesis of high altitude pulmonary edema: does alveolar epithelial lining fluid vascular endothelial growth factor exacerbate capillary leak?
    Robert J Kaner
    Division of Pulmonary and Critical Care Medicine, Department of Genetic Medicine, Weill Medical College of Cornell University, 515 East 71st Street S 1000, New York, NY 10021, USA
    High Alt Med Biol 5:399-409. 2004
    ..to result in compromise of alveolar epithelial tight junctions and experimental animal studies in which pulmonary edema is induced when VEGF is overexpressed in the alveolar epithelium, suggest a mechanism...
  42. pmc A comparison of continuous and bi-level positive airway pressure non-invasive ventilation in patients with acute cardiogenic pulmonary oedema: a meta-analysis
    Kwok M Ho
    Department of Intensive Care, Royal Perth Hospital, Perth, Western Australia, Australia
    Crit Care 10:R49. 2006
    ....
  43. ncbi Association of polymorphisms in pulmonary surfactant protein A1 and A2 genes with high-altitude pulmonary edema
    Shweta Saxena
    Institute of Genomics and Integrative Biology, Delhi, India
    Chest 128:1611-9. 2005
    A potential pathogenetic cofactor for the development of high-altitude pulmonary edema (HAPE) is an increase in capillary permeability, which could occur as a result of an inflammatory reaction and/or free-radical-mediated injury to the ..
  44. ncbi Acute pulmonary edema, capillaritis and alveolar hemorrhage: pulmonary manifestations coexistent in antiphospholipid syndrome and systemic lupus erythematosus?
    V A Nguyen
    Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria
    Lupus 14:557-60. 2005
    ..described the radiological features of three patients with pulmonary and SLE-associated APS, manifested with pulmonary edema, capillaritis and alveolar hemorrhage...
  45. ncbi Severe subarachnoid hemorrhage with pulmonary edema successfully treated by intra-aneurysmal embolization using Guglielmi detachable coils--Two case reports
    M Fujimura
    Department of Neurosurgery, Aomori Prefectural Central Hospital, Aomori
    Neurol Med Chir (Tokyo) 41:135-9. 2001
    ..Both patients were comatose on admission. Chest radiography disclosed pulmonary edema. They were conservatively treated under controlled ventilation, but cardiopulmonary dysfunction persisted ..
  46. ncbi The detrimental role of inducible nitric oxide synthase in the pulmonary edema caused by hypercalcemia in conscious rats and isolated lungs
    Hsing I Chen
    Institute of Medical Sciences and of Integrative Physiology and Clinical Sciences, Tzu Chi University, Hualien, Taiwan
    J Biomed Sci 15:227-38. 2008
    We aim to test the hypothesis that hypercalcemia produces pulmonary edema (PE) and to elucidate the mechanism. Experimentations were carried out in conscious rats and isolated perfused rat lungs...
  47. ncbi Low degree of anesthesia increases the risk of neurogenic pulmonary edema development
    J Sedy
    Institute of Experimental Medicine, ASCR, Prague, Czech Republic
    Med Hypotheses 70:308-13. 2008
    Neurogenic pulmonary edema is an acute life-threatening complication following central nervous system injury. The exact pathogenic mechanism leading to its development is still unclear...
  48. ncbi Na,K-ATPase overexpression improves alveolar fluid clearance in a rat model of elevated left atrial pressure
    Zaher S Azzam
    Technion, Israel Institute of Technology, Haifa, Israel
    Circulation 105:497-501. 2002
    ..We reasoned that adenovirus-mediated transfer of an Na,K-ATPase beta-subunit gene to the alveolar epithelium could improve AFC in rat lungs in the presence of acutely elevated LAP...
  49. doi Thoracic impedance vs chest radiograph to diagnose acute pulmonary edema in the ED
    Dave Milzman
    Department of Emergency Medicine, Georgetown University Medical Center and Washington Hospital Center, Washington, DC 20010, USA
    Am J Emerg Med 27:770-5. 2009
    We sought to investigate the relationship between thoracic impedance (Zo) and pulmonary edema on chest radiography in patients presenting to the emergency department (ED) with signs and symptoms of acute decompensated heart failure (ADHF).
  50. doi Usefulness of lung ultrasound in the bedside distinction between pulmonary edema and exacerbation of COPD
    Giovanni Volpicelli
    Department of Emergency Medicine, University of Torino, San Luigi Gonzaga Hospital, Orbassano, Torino, Italy
    Emerg Radiol 15:145-51. 2008
    ..causes of acute dyspnea in the emergency setting, particularly focusing on differential diagnosis of pulmonary edema and exacerbation of chronic obstructive pulmonary disease (COPD)...
  51. pmc Evaluation of a thoracic ultrasound training module for the detection of pneumothorax and pulmonary edema by prehospital physician care providers
    Vicki E Noble
    Department of Emergency Medicine, Massachusetts General Hospital, 55 Fruit St, Boston, Massachusetts, USA
    BMC Med Educ 9:3. 2009
    ..skills for two important TUS applications; the identification of B-lines (used in the US diagnosis of pulmonary edema) and the identification of lung sliding and comet tails (used in the US diagnosis of pneumothorax)...
  52. doi [The gynecological TURP syndrome. Severe hyponatremia and pulmonary edema during hysteroscopy]
    G Serocki
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Universitätsklinikum Schleswig Holstein UKSH, Campus Kiel, Schwanenweg 21, 24105 Kiel, Deutschland
    Anaesthesist 58:30-4. 2009
    ..under general anaesthesia, suffering from severe absorption syndrome leading to hyponatremia of 106 mEq/l and pulmonary edema necessitating subsequent admission to ICU...
  53. ncbi Neurogenic pulmonary edema
    A Baumann
    Departement d Anesthesie Reanimation, Centre Hospitalier Universitaire de Nancy, Hopital Central, Nancy, France
    Acta Anaesthesiol Scand 51:447-55. 2007
    Neurogenic pulmonary edema (NPE) is usually defined as an acute pulmonary edema occurring shortly after a central neurologic insult...
  54. ncbi Effects of altitude and exercise on pulmonary capillary integrity: evidence for subclinical high-altitude pulmonary edema
    Marlowe W Eldridge
    John Rankin Laboratory of Pulmonary Medicine, Department of Pediatrics, Univ of Wisconsin, Medical School, H4 422 Clinical Sciences Center, 600 Highland Ave, Madison, WI 53792 4108, USA
    J Appl Physiol (1985) 100:972-80. 2006
    Strenuous exercise may be a significant contributing factor for development of high-altitude pulmonary edema, particularly at low or moderate altitudes...
  55. doi Frequent subclinical high-altitude pulmonary edema detected by chest sonography as ultrasound lung comets in recreational climbers
    Lorenza Pratali
    Institute of Clinical Physiology, CNR, Pisa, Italy
    Crit Care Med 38:1818-23. 2010
    ..The aim of this study was to evaluate, by chest sonography, the incidence of interstitial pulmonary edema in recreational high-altitude climbers.
  56. ncbi Noninvasive ventilation in acute cardiogenic pulmonary edema: systematic review and meta-analysis
    Josep Masip
    ICU Department, Hospital Dos de Maig Consorci Sanitari Integral, University of Barcelona, Barcelona, Spain
    JAMA 294:3124-30. 2005
    In patients with acute cardiogenic pulmonary edema noninvasive ventilation may reduce intubation rate, but the impact on mortality and the superiority of one technique over another have not been clearly established.
  57. ncbi Bedside lung ultrasound in the assessment of alveolar-interstitial syndrome
    Giovanni Volpicelli
    Department of Emergency Medicine, S Luigi Hospital, Orbassano, TO, 10043, Italy
    Am J Emerg Med 24:689-96. 2006
    ....
  58. ncbi Lung edema clearance: 20 years of progress: invited review: role of aquaporin water channels in fluid transport in lung and airways
    Zea Borok
    Will Rogers Institute Pulmonary Research Center, Department of Medicine, University of Southern California, Los Angeles 90033 3721, USA
    J Appl Physiol 93:2199-206. 2002
    ..However, the possibility remains that AQPs may play a role in lung physiology under conditions of stress and/or injury not yet tested or in functions unrelated to transepithelial fluid transport...
  59. pmc Alveolar epithelial beta2-adrenergic receptors
    Gokhan M Mutlu
    Northwestern University Feinberg School of Medicine, Pulmonary and Critical Care Medicine, 240 E Huron Street, McGaw M 300, Chicago, IL 60611, USA
    Am J Respir Cell Mol Biol 38:127-34. 2008
    ..agonists to accelerate alveolar fluid clearance in patients with cardiogenic and noncardiogenic pulmonary edema. In this review, we summarize the role of beta(2)-adrenergic receptors in the alveolar epithelium with ..
  60. ncbi Mechanisms of pulmonary edema clearance
    Gokhan M Mutlu
    Pulmonary and Critical Care Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Am J Physiol Lung Cell Mol Physiol 289:L685-95. 2005
    The mechanisms of pulmonary edema resolution are different from those regulating edema formation...
  61. ncbi "Ultrasound comet-tail images": a marker of pulmonary edema: a comparative study with wedge pressure and extravascular lung water
    Eustachio Agricola
    Division of Non Invasive Cardiology, Cardiothoracic Department, San Raffaele Hospital, Istituto di Richerche e Cura a carattere Scientifico, Milano, Italy
    Chest 127:1690-5. 2005
    Echographic examination of the lung surface may reveal multiple "comet-tail images" originating from water-thickened interlobular septa. These images could be useful for noninvasive assessment of interstitial pulmonary edema.
  62. doi Noninvasive ventilation in acute cardiogenic pulmonary edema
    Alasdair Gray
    Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
    N Engl J Med 359:142-51. 2008
    ..ventilation [NIPPV]) appears to be of benefit in the immediate treatment of patients with acute cardiogenic pulmonary edema and may reduce mortality...
  63. ncbi Physiological aspects of high-altitude pulmonary edema
    Peter Bartsch
    Department of Internal Medicine VII, Division of Sports Medicine, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    J Appl Physiol (1985) 98:1101-10. 2005
    High-altitude pulmonary edema (HAPE) develops in rapidly ascending nonacclimatized healthy individuals at altitudes above 3,000 m...
  64. pmc Clara cell protein (CC16), a marker of lung epithelial injury, is decreased in plasma and pulmonary edema fluid from patients with acute lung injury
    Jonathan A Kropski
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 2650, USA
    Chest 135:1440-7. 2009
    ..We tested the diagnostic and prognostic utility of CC16 in patients with non-trauma-related ALI/ARDS compared to a control group of patients with acute cardiogenic pulmonary edema (CPE).
  65. ncbi Mechanism of fulminant pulmonary edema caused by enterovirus 71
    Shang Jyh Kao
    Department of Chest Medicine, Shin Kong Wu Ho Su Memorial Hospital, School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan, Republic of China
    Clin Infect Dis 38:1784-8. 2004
    b>Pulmonary edema (PE) may occur with enterovirus 71 (EV71) infection. We monitored arterial pressure (AP) and heart rate (HR) in patients with EV71 infection and analyzed the variability of AP and HR...
  66. ncbi The lung is the major site that produces nitric oxide to induce acute pulmonary oedema in endotoxin shock
    R P Lee
    Institute of Nursing and Medical Sciences and Department of Physiology, Tzu Chi University, Hualien, Taiwan, Republic of China
    Clin Exp Pharmacol Physiol 28:315-20. 2001
    ..Inhalation of NO for patients with sepsis may be used with clinical caution. Therapeutic consideration of lung extracorporeal perfusion with PSS and pharmacological pretreatment with iNOS inhibitors may be warranted...
  67. pmc Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury
    Carolyn S Calfee
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA, 94143 0111, USA
    Intensive Care Med 35:248-57. 2009
    ..adhesion molecule-1 (sICAM-1), a marker of alveolar epithelial and endothelial injury, differ in patients with hydrostatic pulmonary edema and acute lung injury (ALI) and are associated with clinical outcomes in patients with ALI.
  68. ncbi An increase of abdominal pressure increases pulmonary edema in oleic acid-induced lung injury
    Michael Quintel
    Institut fur Anasthesiologie und Operative Intensivmedizin, Universitatsklinikum, Mannheim, Mannheim, Germany
    Am J Respir Crit Care Med 169:534-41. 2004
    ..We conclude that in OA-injured lung, the increase of IAP increases the amount of edema...
  69. ncbi Pulmonary edema after transfusion: how to differentiate transfusion-associated circulatory overload from transfusion-related acute lung injury
    Ognjen Gajic
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Crit Care Med 34:S109-13. 2006
    b>Pulmonary edema is an under-recognized and potentially serious complication of blood transfusion. Distinct mechanisms include adverse immune reactions and circulatory overload...
  70. ncbi Pulmonary blood flow heterogeneity during hypoxia and high-altitude pulmonary edema
    Susan R Hopkins
    Department of Medicine, Division of Physiology 0623A, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Am J Respir Crit Care Med 171:83-7. 2005
    ..proposed to expose parts of the pulmonary capillary bed to high pressure and vascular injury in high-altitude pulmonary edema (HAPE)...
  71. ncbi Pulmonary histopathological alterations in patients with acute respiratory failure: an autopsy study
    Alexandre de Matos Soeiro
    Faculdade de Medicina da Universidade de Sao Paulo FMUSP, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    J Bras Pneumol 34:67-73. 2008
    ....
  72. ncbi New classification and clinical characteristics of reexpansion pulmonary edema after treatment of spontaneous pneumothorax
    Yun Kwon Kim
    Department of Emergency Medicine, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea
    Am J Emerg Med 27:961-7. 2009
    Reexpansion pulmonary edema (REPE) is a rare yet sometimes fatal complication associated with the treatment of lung diseases such as pleural effusion, pneumothorax, and hemothorax...
  73. ncbi Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome
    L B Ware
    Cardiovascular Research Institute, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0130, USA
    Am J Respir Crit Care Med 163:1376-83. 2001
    ..studies have shown that intact alveolar epithelial fluid transport function is critical for resolution of pulmonary edema and acute lung injury, we measured net alveolar fluid clearance in 79 patients with acute lung injury or the ..
  74. ncbi Stress Doppler echocardiography for identification of susceptibility to high altitude pulmonary edema
    E Grunig
    Department of Cardiology, University of Heidelberg, Germany
    J Am Coll Cardiol 35:980-7. 2000
    ..This prospective single-blinded study was performed to quantitate noninvasive pulmonary artery systolic pressure (PASP) responses to prolonged acute hypoxia and normoxic exercise...
  75. pmc Role of lung-marginated monocytes in an in vivo mouse model of ventilator-induced lung injury
    Michael R Wilson
    Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea, United Kingdom
    Am J Respir Crit Care Med 179:914-22. 2009
    ..Inflammatory subset Gr-1(high) monocytes are recruited to sites of inflammation and have been implicated in acute lung injury induced by systemic endotoxin...
  76. ncbi The beta-agonist lung injury trial (BALTI): a randomized placebo-controlled clinical trial
    Gavin D Perkins
    Department of Intensive Care Medicine, Birmingham Heartlands Hospital, UK
    Am J Respir Crit Care Med 173:281-7. 2006
    ..Experimental data suggest that manipulation of alveolar fluid clearance with beta-agonists can accelerate the resolution of alveolar edema and improve survival...
  77. pmc Accurate characterization of extravascular lung water in acute respiratory distress syndrome
    David M Berkowitz
    Division of Pulmonary, Allergy and Critical Care, Department of Medicine, Emory University, Atlanta, GA, USA
    Crit Care Med 36:1803-9. 2008
    Measurements of extravascular lung water (EVLW) correlate to the degree of pulmonary edema and have substantial prognostic information in critically ill patients...
  78. ncbi Intravascular volume monitoring and extravascular lung water in septic patients with pulmonary edema
    Sandrine Boussat
    Polyvalent Intensive Care Unit, University Hospital of Besancon, Boulevard Fleming, 25030 Besancon Cedex, France
    Intensive Care Med 28:712-8. 2002
    ..To evaluate whether different indicators using for guiding volume expansion are valuable tools to assess edematous lung injury in patients with septic shock...
  79. ncbi Acute respiratory distress syndrome of the contralateral lung after reexpansion pulmonary edema of a collapsed lung
    Charles Her
    Department of Anesthesiology, New York Medical College, Valhalla, NY, USA
    J Clin Anesth 16:244-50. 2004
    To report that leukocyte-mediated acute injury may develop in a nonhypoxic lung after hypoxia-reoxygenation injury of the hypoxic lung and in other systemic organs in patients with reexpansion pulmonary edema.
  80. pmc Leptin resistance protects mice from hyperoxia-induced acute lung injury
    Amy Bellmeyer
    Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Am J Respir Crit Care Med 175:587-94. 2007
    ..Human data suggest that the incidence of acute lung injury is reduced in patients with type II diabetes mellitus. However, the mechanisms by which diabetes confers protection from lung injury are unknown...
  81. ncbi Pulmonary edema following instillation of topical phenylephrine eyedrops in a child under general anesthesia
    Jaichandran Venkatakrishnan
    Department of Anesthesiology, Sankara Nethralaya, Tamil Nadu, India
    Eur J Ophthalmol 21:115-7. 2011
    To report a case of pulmonary edema, in a child under general anesthesia, due to iatrogenic acute hypertensive crisis following instillation of 1 drop of 5% phenylephrine eyedrops.
  82. ncbi Exacerbation of acute pulmonary edema during assisted mechanical ventilation using a low-tidal volume, lung-protective ventilator strategy
    R H Kallet
    Department of Anesthesia, University of California, San Francisco, at San Francisco General Hospital, 94110, USA
    Chest 116:1826-32. 1999
    To assess the magnitude of negative intrathoracic pressure development in a patient whose pulmonary edema acutely worsened immediately following the institution of a low-tidal volume (VT) strategy.
  83. ncbi Acute neurogenic pulmonary edema: case reports and literature review
    Ricardo B V Fontes
    Neurosurgery and Neurology Clinic Pinheiros, Sao Paulo, Brazil
    J Neurosurg Anesthesiol 15:144-50. 2003
    Neurogenic pulmonary edema (NPE) is an underdiagnosed clinical entity. Its pathophysiology is multifactorial but largely unknown. We report two cases of NPE and review the literature on NPE cases reported since 1990...
  84. doi Usefulness of lung impedance-guided pre-emptive therapy to prevent pulmonary edema during ST-elevation myocardial infarction and to improve long-term outcomes
    Michael Shochat
    Heart Institute, Hillel Yaffe Medical Center, Hadera, Rappaport School of Medicine, Technion, Haifa, Israel
    Am J Cardiol 110:190-6. 2012
    ..sustaining an ST-segment elevation myocardial infarction (STEMI) frequently develop pulmonary congestion or pulmonary edema (PED)...
  85. pmc Adenosine protected against pulmonary edema through transporter- and receptor A2-mediated endothelial barrier enhancement
    Qing Lu
    Vascular Research Laboratory, Providence Veterans Affairs Medical Center, Department of Medicine, Alpert Medical School of Brown University, Providence, Rhode Island 02908, USA
    Am J Physiol Lung Cell Mol Physiol 298:L755-67. 2010
    ..The data suggest that adenosine deaminase inhibition may be useful in treatment of pulmonary edema in settings of ALI.
  86. ncbi Transthoracic monitoring of the impedance of the right lung in patients with cardiogenic pulmonary edema
    G Charach
    Department of Internal Medicine C, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Crit Care Med 29:1137-44. 2001
    ..To evaluate the suitability of the new electrical impedance monitor RS-205 for monitoring of cardiogenic pulmonary edema (CPE). DESIGN: Prospective, controlled study...
  87. ncbi Pulmonary edema in meningococcal septicemia associated with reduced epithelial chloride transport
    Michael Eisenhut
    Institute of Child Health, University of Liverpool, UK
    Pediatr Crit Care Med 7:119-24. 2006
    To test the hypothesis that meningococcal septicemia-related pulmonary edema is associated with a systemic abnormality of epithelial sodium and chloride transport and to investigate an association with hormones regulating Na transport.
  88. ncbi [Unilateral neurogenic pulmonary edema. A case report]
    C Perrin
    Service de Pneumologie, Hopital Pasteur, CHU, 30, avenue de la Voie Romaine, BP 69, 06002 Nice cedex 1
    Rev Pneumol Clin 60:43-5. 2004
    ..The patient suddenly developed unilateral pulmonary edema. Bilateral alveolar opacities is the usual radiological aspect of neurogenic pulmonary edema but a unilateral ..
  89. ncbi Patent foramen ovale and high-altitude pulmonary edema
    Yves Allemann
    Department of Cardiology, Swiss Cardiovascular Center Bern, University Hospital, Inselspital, Bern, Switzerland
    JAMA 296:2954-8. 2006
    Individuals susceptible to high-altitude pulmonary edema (HAPE) are characterized by exaggerated pulmonary hypertension and arterial hypoxemia at high altitude, but the underlying mechanism is incompletely understood...
  90. ncbi Ginkgo biloba extract prevents high altitude pulmonary edema in rats
    John T Berg
    Department of Tropical Medicine, Medical Microbiology, and Pharmacology, University of Hawaii at Manoa, 1951 East West Road, Honolulu, HI 96822, USA
    High Alt Med Biol 5:429-34. 2004
    Ginkgo biloba reduces the severity of acute mountain sickness in humans, but protection against high altitude pulmonary edema (HAPE) has not been reported. This study was conducted to determine if G...
  91. ncbi [Asymmetric pulmonary perfusion causing unilateral pulmonary edema as a complication of acute myocardial infarction]
    Carlos Pena
    Servicio de Cardiologia, Hospital Clinico Universitario, Santiago de Compostela, La Coruna, Spain
    Rev Esp Cardiol 58:875-7. 2005
    Acute unilateral pulmonary edema is an unusual clinical condition occasionally associated with severe mitral valve insufficiency...
  92. ncbi The role of activation of neutrophils and microvascular pressure in acute pulmonary edema
    C E Patterson
    Department of Physiology Biophysics, Indiana University School of Medicine, Indianapolis 46223
    Am Rev Respir Dis 140:1052-62. 1989
    ....
  93. ncbi A difficult diagnosis: right unilateral cardiogenic pulmonary edema. Usefulness of biochemical markers of heart failure for the correct diagnosis
    Antonio D'Aloia
    Division of Cardiology, Unit of Polycardiography, University of Brescia, Brescia, Italy
    Ital Heart J 6:771-4. 2005
    We describe a case of unilateral pulmonary edema occurring in a young woman affected by hypertrophic cardiomyopathy complicated by acute worsening of mitral regurgitation...
  94. ncbi Exposure to hypoxia results in uneven pulmonary blood flow distribution prior to pulmonary edema
    Tetsuya Urano
    Department of Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1193, Japan
    Tokai J Exp Clin Med 30:193-202. 2005
    The effects of hypoxia on pulmonary arterial pressure (PAP) and on development of pulmonary edema, ascertained by changes in lung water and pulmonary vascular permeability were studied in rats using bronchoalveolar lavage (BAL)...
  95. ncbi Pulmonary edema: pathophysiology and diagnosis
    J F Murray
    University of California San Francisco, San Francisco, California, USA
    Int J Tuberc Lung Dis 15:155-60, i. 2011
    ..Lymphatic drainage can increase several-fold, which means that pulmonary edema-defined as an increase in extravascular water content of the lungs-cannot occur until the rate of fluid ..
  96. pmc Long-term survival and quality of life after transfusion-associated pulmonary edema in critically ill medical patients
    Guangxi Li
    Division of Pulmonary and Critical Care Medicine, Old Marion Hall, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
    Chest 137:783-9. 2010
    ..Prior outcome studies of TACO and TRALI have focused on short-term morbidity and mortality, but the long-term survival and quality of life (QOL) of these patients remain unknown...
  97. ncbi Acute pulmonary edema caused by hypoglycemia due to insulin overdose
    Daigaku Uchida
    Department of Endocrinology and Metabolism, Kimitsu Central Hospital, Chiba
    Intern Med 43:1056-9. 2004
    We report a very rare case of acute pulmonary edema caused by hypoglycemia from insulin overdose during an attempted suicide. A 16-year-old woman with type 1 diabetes was brought to our hospital because of hypoglycemic coma...
  98. ncbi Therapeutic efficacy of milrinone in the management of enterovirus 71-induced pulmonary edema
    Shih Min Wang
    Department of Emergency Medicine, College of Medicine, National Cheng Kung University and Hospital, Tainan, Taiwan
    Pediatr Pulmonol 39:219-23. 2005
    ..Brain-stem encephalitis and pulmonary edema are severe complications that can lead to death...
  99. ncbi Comparison of a single indicator and gravimetric technique for estimation of extravascular lung water in endotoxemic pigs
    Patrik Rossi
    Department of Physiology and Pharmacology, Section of Anaesthesiology and Intensive Care Medicine, Karolinska Institute, Stockholm, Sweden
    Crit Care Med 34:1437-43. 2006
    ..To compare the single thermal indicator dilution (STID) technique for measurement of extravascular lung water (EVLW(STID)) with gravimetrically determined EVLW (EVLW(GRAV)) in anesthetized pigs under sham and endotoxemic conditions...
  100. ncbi Importance of anesthesia for the genesis of neurogenic pulmonary edema in spinal cord injury
    Manoel Baldoino Leal Filho
    Curso de Pósgraduação em Ciências Médicas, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, PO Box 6111, 13084 971 Campinas, SP, Brazil
    Neurosci Lett 373:165-70. 2005
    There are reports describing both provocation and inhibition of neurogenic pulmonary edema by anesthetic drugs...
  101. doi Prehospital lung ultrasound in the distinction between pulmonary edema and exacerbation of chronic obstructive pulmonary disease
    Peter Michael Zechner
    Medizinercorps Graz, Austrian Red Cross, Naglergasse, Austria
    Am J Emerg Med 28:389.e1-2. 2010
    We present 2 cases of dyspneic patients, where prehospital lung ultrasound helped to distinguish between pulmonary edema and acute exacerbation of chronic obstructive pulmonary disease.

Research Grants81

  1. REFLEXES IN LEFT VENTRICULAR DYSFUNCTION
    CHULANI KAPPAGODA; Fiscal Year: 2003
    ..Renal functions are also altered. As LVD progresses, PVC evolves into pulmonary edema. This application addresses two issues: (1) the activity of sensory receptors in the lung when the pulmonary ..
  2. Lung Perfusion Heterogeneity and Mechanisms of Edema
    Susan Hopkins; Fiscal Year: 2007
    ..of pulmonary blood flow and increased pulmonary capillary pressures interact to affect the development of pulmonary edema. High altitude pulmonary edema (HAPE), an acute potentially fatal edema is used as a disease model, to allow ..
  3. Lung Fluid Balance and Mesenchymal Stem Cells
    Michael Matthay; Fiscal Year: 2009
    ..Aim 1 is designed to determine the therapeutic effects of intrapulmonary and intravenous delivery of MSC on pulmonary edema and survival in clinically relevant mouse models of acute lung injury...
  4. Repair of Airway Epithelium Following Chlorine Lung Injury
    Gary W Hoyle; Fiscal Year: 2010
    ..respiratory epithelial cell barrier contributes to other sequelae observed in acute lung injury, including pulmonary edema, airway obstruction, inflammation, and respiratory infections...
  5. REFLEXES IN LEFT VENTRICULAR DYSFUNCTION
    CHULANI KAPPAGODA; Fiscal Year: 2002
    ..Renal functions are also altered. As LVD progresses, PVC evolves into pulmonary edema. This application addresses two issues: (1) the activity of sensory receptors in the lung when the pulmonary ..
  6. REFLEXES IN LEFT VENTRICULAR DYSFUNCTION
    CHULANI KAPPAGODA; Fiscal Year: 2000
    ..Renal functions are also altered. As LVD progresses, PVC evolves into pulmonary edema. This application addresses two issues: (1) the activity of sensory receptors in the lung when the pulmonary ..
  7. REFLEXES IN LEFT VENTRICULAR DYSFUNCTION
    CHULANI KAPPAGODA; Fiscal Year: 2001
    ..Renal functions are also altered. As LVD progresses, PVC evolves into pulmonary edema. This application addresses two issues: (1) the activity of sensory receptors in the lung when the pulmonary ..
  8. CNS PROCESSING OF BRONCHOPULMONARY FIBER AFFERENT INPUT
    Ann Bonham; Fiscal Year: 1992
    ..analog) and capsaicin; by environmental toxicants such as ozone and cigarette smoke, and during severe pulmonary edema. When stimulated the bronchopulmonary C fiber receptors produce rapid shallow breathing (that may be preceded ..
  9. LUNG FUNCTION IN PROLONGED HEART FAILURE
    Marie Francoise Doursout; Fiscal Year: 2004
    DESCRIPTION (Applicant's abstract): Pulmonary edema (too much fluid in the lungs) is one of the most common and serious complications of heart failure...
  10. LUNG FUNCTION IN PROLONGED HEART FAILURE
    Marie Francoise Doursout; Fiscal Year: 2003
    DESCRIPTION (Applicant's abstract): Pulmonary edema (too much fluid in the lungs) is one of the most common and serious complications of heart failure...
  11. LUNG FUNCTION IN PROLONGED HEART FAILURE
    Robert Drake; Fiscal Year: 2001
    DESCRIPTION (Applicant's abstract): Pulmonary edema (too much fluid in the lungs) is one of the most common and serious complications of heart failure...
  12. LUNG FUNCTION IN PROLONGED HEART FAILURE
    Marie Francoise Doursout; Fiscal Year: 2002
    DESCRIPTION (Applicant's abstract): Pulmonary edema (too much fluid in the lungs) is one of the most common and serious complications of heart failure...
  13. NEUROGENIC INFLUENCES ON LUNG FLUID AND SOLUTE EXCHANGE
    Fred Minnear; Fiscal Year: 1990
    ..changes and acute pulmonary vascular hypertension have been postulated as mechanisms in the development of pulmonary edema after a variety of clinical syndromes such as subarachnoid hemorrhage, intracranial hypertension, cerebral ..
  14. STRESS FAILURE IN PULMONARY CAPILLARIES
    John West; Fiscal Year: 1993
    ..objective of this project is to obtain a better understanding of a hitherto unrecognized mechanism of pulmonary edema and hemorrhage, namely mechanical stress disruption of pulmonary capillaries...
  15. Lung Perfusion Heterogeneity and Mechanisms of Edema
    Susan R Hopkins; Fiscal Year: 2010
    ..of pulmonary blood flow and increased pulmonary capillary pressures interact to affect the development of pulmonary edema. High altitude pulmonary edema (HAPE), an acute potentially fatal edema is used as a disease model, to allow ..
  16. Lung Perfusion Heterogeneity and Mechanisms of Edema
    Susan Hopkins; Fiscal Year: 2009
    ..of pulmonary blood flow and increased pulmonary capillary pressures interact to affect the development of pulmonary edema. High altitude pulmonary edema (HAPE), an acute potentially fatal edema is used as a disease model, to allow ..
  17. Lung Perfusion Heterogeneity and Mechanisms of Edema
    Susan Hopkins; Fiscal Year: 2006
    ..of pulmonary blood flow and increased pulmonary capillary pressures interact to affect the development of pulmonary edema. High altitude pulmonary edema (HAPE), an acute potentially fatal edema is used as a disease model, to allow ..
  18. LUNG EPITHELIAL ION-LIQUID TRANSPORT DURING DEVELOPMENT
    Richard Bland; Fiscal Year: 1993
    ..which should provide useful information for developing effective measures to inhibit or promote resolution of pulmonary edema in infants, children and adults...
  19. Heme Oxygenase-1 in Lung Ischemia-Reperfusion Injury
    Patty J Lee; Fiscal Year: 2010
    ..lung injury during lung transplantation/surgery, thromboembolectomy, pulmonary embolism, and re-expansion pulmonary edema, all of which lead to clinically significant respiratory failure but for which no specific therapies exist...
  20. Heme Oxygenase-1 in Lung Ischemia-Reperfusion Injury
    PATTY LEE; Fiscal Year: 2009
    ..lung injury during lung transplantation/surgery, thromboembolectomy, pulmonary embolism, and re-expansion pulmonary edema, all of which lead to clinically significant respiratory failure but for which no specific therapies exist...
  21. TRANSPORT ACROSS ALVEOLAR CAPILLARY MEMBRANE
    AUBREY TAYLOR; Fiscal Year: 1992
    ..b>Pulmonary edema can result because capillaries are abnormally leaky to plasma proteins and/or capillary pressure is elevated...
  22. PREVENTION OF INCREASED VASCULAR PERMEABILITY
    Fred Minnear; Fiscal Year: 1992
    ..by changes in hemodynamics; (2) determine the validity of beta-agonists as potential therapeutic agents for pulmonary edema and increased vascular permeability, and (3) determine the mechanism, from stimulation of adenylate cyclase ..
  23. ADVERSE EVENTS WITH MAGNESIUM SULFATE
    George Macones; Fiscal Year: 2000
    ..While MgSO4 is felt to have a tolerable side-effect profile, there is a risk of pulmonary edema (the most dangerous adverse event) with its use with estimates as high as 8%...
  24. ADVERSE EVENTS WITH MAGNESIUM SULFATE
    George Macones; Fiscal Year: 1999
    ..While MgSO4 is felt to have a tolerable side-effect profile, there is a risk of pulmonary edema (the most dangerous adverse event) with its use with estimates as high as 8%...
  25. PULMONARY EDEMA FROM SYNTHETIC SMOKE INHALATION
    CHARLES HALES; Fiscal Year: 1991
    ..There is often a lag phase between the fire and the onset of lung injury such as pulmonary edema or ARDS during which time inflammatory mediators may have to build up to cause the lung damage...
  26. MECHANISMS OF FLUID BALANCE IN LOWER VERTEBRATE LUNGS
    ALLAN SMITS; Fiscal Year: 1991
    ..applicant's abstract) One of the most life-threatening clinical conditions in respiratory medicine today is pulmonary edema, in which an accumulation of fluid in the lung tissue greatly impedes the diffusion of oxygen and carbon ..
  27. INTEGRIN AVB3 SIGNALLING IN LUNG ENDOTHELIUM
    Sunita Bhattacharya; Fiscal Year: 1999
    ..objective is to understand mechanisms controlling lung endothelial permeability that may predispose to pulmonary edema. Previous work indicates ligation of the alpha(v)beta(3) integrin receptor on lung endothelium by the ..
  28. Heme Oxygenase-1 in Lung Ischemia-Reperfusion Injury
    PATTY LEE; Fiscal Year: 2006
    ..inciting injury during lung transplantation/surgery, thromboembolectomy, pulmonary embolism, and re-expansion pulmonary edema. These disorders have high mortalities with limited therapeutic options...
  29. Heme Oxygenase-1 in Lung Ischemia-Reperfusion Injury
    PATTY LEE; Fiscal Year: 2007
    ..inciting injury during lung transplantation/surgery, thromboembolectomy, pulmonary embolism, and re-expansion pulmonary edema. These disorders have high mortalities with limited therapeutic options...
  30. Heme Oxygenase-1 in Lung Ischemia-Reperfusion Injury
    PATTY LEE; Fiscal Year: 2005
    ..inciting injury during lung transplantation/surgery, thromboembolectomy, pulmonary embolism, and re-expansion pulmonary edema. These disorders have high mortalities with limited therapeutic options...
  31. Heme Oxygenase-1 in Lung Ischemia-Reperfusion Injury
    PATTY LEE; Fiscal Year: 2004
    ..inciting injury during lung transplantation/surgery, thromboembolectomy, pulmonary embolism, and re-expansion pulmonary edema. These disorders have high mortalities with limited therapeutic options...
  32. LV DYSFUNCTION WITH MASSIVE SYMPATHETIC ACTIVITY
    CHARLES PILATI; Fiscal Year: 1993
    ..central nervous system (CNS) often intensely activates the sympathetic nervous system (SNS), and neurogenic pulmonary edema (NPE) frequently results...
  33. LV DYSFUNCTION WITH MASSIVE SYMPATHETIC ACTIVITY
    CHARLES PILATI; Fiscal Year: 1990
    ..central nervous system (CNS) often intensely activates the sympathetic nervous system (SNS), and neurogenic pulmonary edema (NPE) frequently results...
  34. Caveolin-1 and NO Regulate PMN-mediated Increases in Vascular Permeability
    Richard Minshall; Fiscal Year: 2009
    ..of polymorphonuclear leukocytes (PMNs) adherent to endothelial cells via ICAM-1 leads to protein-rich pulmonary edema formation and acute lung injury...
  35. Caveolin-1 and NO Regulate PMN-mediated Increases in Vascular Permeability
    Richard D Minshall; Fiscal Year: 2010
    ..of polymorphonuclear leukocytes (PMNs) adherent to endothelial cells via ICAM-1 leads to protein-rich pulmonary edema formation and acute lung injury...
  36. Caveolin-1 and NO Regulate PMN-mediated Increases in Vascular Permeability
    Richard D Minshall; Fiscal Year: 2011
    ..of polymorphonuclear leukocytes (PMNs) adherent to endothelial cells via ICAM-1 leads to protein-rich pulmonary edema formation and acute lung injury...
  37. BRONCHIAL CIRCULATION AND LUNG FLUID BALANCE
    George Kramer; Fiscal Year: 1991
    ..The above observations suggest the following hypothesis: The development of pulmonary edema during inflammatory lung disease results in part from the highly reactive bronchial circulation...
  38. ONCOTIC PRESSURE AND EXTRAVASCULAR LUNG WATER IN ARDS
    Gregory Martin; Fiscal Year: 2000
    ..ARDS is defined by acute impairment of oxygenation and radiographic infiltrates compatible with pulmonary edema without increased hydrostatic pressures...
  39. PULMONARY VASCULAR ACTIONS OF THROMBOXANE A2
    MARTIN OGLETREE; Fiscal Year: 1980
    Elevated pulmonary microvascular pressures and high lung vascular permeability are two causes of pulmonary edema. I wish to study the effects of thromboxane A2 on pulmonary vascular resistance and lung vascular permeability to determine ..
  40. ONCOTIC PRESSURE AND EXTRAVASCULAR LUNG WATER IN ARDS
    Gregory Martin; Fiscal Year: 2004
    ..ARDS is defined by acute impairment of oxygenation and radiographic infiltrates compatible with pulmonary edema without increased hydrostatic pressures...
  41. ONCOTIC PRESSURE AND EXTRAVASCULAR LUNG WATER IN ARDS
    Gregory Martin; Fiscal Year: 2003
    ..ARDS is defined by acute impairment of oxygenation and radiographic infiltrates compatible with pulmonary edema without increased hydrostatic pressures...
  42. ONCOTIC PRESSURE AND EXTRAVASCULAR LUNG WATER IN ARDS
    Gregory Martin; Fiscal Year: 2001
    ..ARDS is defined by acute impairment of oxygenation and radiographic infiltrates compatible with pulmonary edema without increased hydrostatic pressures...
  43. LUNG PERFUSION BY POSITRON EMISSION TOMOGRAPHY
    Daniel Schuster; Fiscal Year: 1999
    The excess accumulation of pulmonary edema, as the most immediate consequence of acute endothelial injury, is the principal cause of hypoxemia, respiratory distress, and the need for mechanical ventilatory support during the adult ..
  44. ONCOTIC PRESSURE AND EXTRAVASCULAR LUNG WATER IN ARDS
    Gregory Martin; Fiscal Year: 2002
    ..ARDS is defined by acute impairment of oxygenation and radiographic infiltrates compatible with pulmonary edema without increased hydrostatic pressures...
  45. A Novel Device for Managing Hypervolemia in CHF Patients
    Mohamed E Labib; Fiscal Year: 2010
    ..excess, repetitive hospitalizations commonly incurred by dialysis patients who suffer from fluid overload and pulmonary edema. Reducing the number of these emergency hospitalizations would undoubtedly be a major cost savings for the ..
  46. Vascular endothelial growth factor induced lung edema
    Robert Kaner; Fiscal Year: 2004
    ..One of the earliest manifestations of ARDS is the development of noncardiogenic pulmonary edema. We have made the novel observation that pulmonary edema is induced by overexpression of the vascular ..
  47. Vascular endothelial growth factor induced lung edema
    Robert Kaner; Fiscal Year: 2003
    ..One of the earliest manifestations of ARDS is the development of noncardiogenic pulmonary edema. We have made the novel observation that pulmonary edema is induced by overexpression of the vascular ..
  48. Vascular endothelial growth factor induced lung edema
    Robert Kaner; Fiscal Year: 2002
    ..One of the earliest manifestations of ARDS is the development of noncardiogenic pulmonary edema. We have made the novel observation that pulmonary edema is induced by overexpression of the vascular ..
  49. Vascular endothelial growth factor induced lung edema
    Robert Kaner; Fiscal Year: 2001
    ..One of the earliest manifestations of ARDS is the development of noncardiogenic pulmonary edema. We have made the novel observation that pulmonary edema is induced by overexpression of the vascular ..
  50. MECHANISMS OF TUMOR NECROSIS FACTOR-INDUCED EDENA
    Arnold Johnson; Fiscal Year: 1991
    ..The central hypothesis of the proposal is that TNF induces a sequence of mediators which result in pulmonary edema. TNF induces endothelial PAF, which may cause (i) endothelial PKC activation, (ii) lung TxA2 generation, (iii)..
  51. Effects of Hypoxia on Alveolar Epithelial Cytoskeleton
    Karen Ridge; Fiscal Year: 2009
    ..many physiological and pathological conditions including chronic obstructive pulmonary disease, cardiogenic pulmonary edema, acute respiratory distress syndrome and ascent to high altitude...
  52. Effects of Hypoxia on Alveolar Epithelial Cytoskeleton
    Karen Ridge; Fiscal Year: 2009
    ..many physiological and pathological conditions including chronic obstructive pulmonary disease, cardiogenic pulmonary edema, acute respiratory distress syndrome and ascent to high altitude...
  53. Effects of Hypoxia on Alveolar Epithelial Cytoskeleton
    Karen Ridge; Fiscal Year: 2006
    ..many physiological and pathological conditions including chronic obstructive pulmonary disease, cardiogenic pulmonary edema, acute respiratory distress syndrome and ascent to high altitude...
  54. Effects of Hypoxia on Alveolar Epithelial Cytoskeleton
    Karen Ridge; Fiscal Year: 2007
    ..many physiological and pathological conditions including chronic obstructive pulmonary disease, cardiogenic pulmonary edema, acute respiratory distress syndrome and ascent to high altitude...
  55. Effects of Hypoxia on Alveolar Epithelial Cytoskeleton
    Karen Ridge; Fiscal Year: 2005
    ..many physiological and pathological conditions including chronic obstructive pulmonary disease, cardiogenic pulmonary edema, acute respiratory distress syndrome and ascent to high altitude...
  56. Adenosine Regulation of Alveolar Fluid Homeostasis
    Phillip Factor; Fiscal Year: 2006
    b>Pulmonary edema is removed from the alveolar airspace by active Na+ transport by alveolar epithelial cells...
  57. Protein Therapy for Acute Lung Injury
    Jahar Bhattacharya; Fiscal Year: 2010
    ..The main pathology in ALI is attributed to pulmonary edema, a direct result of endothelial (EC) barrier deterioration in the lung...
  58. MICROPUNCTURE STUDIES OF LUNG WATER AND SOLUTE EXCHANGE
    Jahar Bhattacharya; Fiscal Year: 2010
    ..microvascular barrier properties by activating the protein, focal adhesion kinase (FAK), thereby blocking pulmonary edema in acute lung injury (ALI)...
  59. Protein Therapy for Acute Lung Injury
    Jahar Bhattacharya; Fiscal Year: 2009
    ..The main pathology in ALI is attributed to pulmonary edema, a direct result of endothelial (EC) barrier deterioration in the lung...
  60. Adenosine Regulation of Alveolar Fluid Homeostasis
    Phillip Factor; Fiscal Year: 2005
    b>Pulmonary edema is removed from the alveolar airspace by active Na+ transport by alveolar epithelial cells...
  61. EFFECTS OF PULMONARY EDEMA ON AIRWAY RESPONSIVENESS
    JAMES SNAPPER; Fiscal Year: 1991
    This proposal examines the mechanisms responsible for pulmonary edema- induced increases in airway responsiveness...
  62. Adenosine Regulation of Alveolar Fluid Homeostasis
    Phillip Factor; Fiscal Year: 2007
    b>Pulmonary edema is removed from the alveolar airspace by active Na+ transport by alveolar epithelial cells...
  63. MICROPUNCTURE STUDIES OF LUNG WATER AND SOLUTE EXCHANGE
    Jahar Bhattacharya; Fiscal Year: 2009
    ..microvascular barrier properties by activating the protein, focal adhesion kinase (FAK), thereby blocking pulmonary edema in acute lung injury (ALI)...
  64. PULMONARY EDEMA IN ARDS--BASIC MECHANISMS AND TREATMENT
    John Butler; Fiscal Year: 1980
    This program is concerned with the basic mechanisms and the treatment of the pulmonary edema associated with the adult respiratory distress syndrome...
  65. BIOCHEMICAL MECHANISMS OF REPERFUSION LUNG INJURY
    Thomas Kennedy; Fiscal Year: 1990
    ..potentially important mechanism of disease in the lung, and might explain many manifestations of re-expansion pulmonary edema, pulmonary edema following lung transplantation, pulmonary embolism or even adult respiratory distress ..