lung diseases


Top Publications

  1. pmc Oxidants and the pathogenesis of lung diseases
    Jonathan Ciencewicki
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Allergy Clin Immunol 122:456-68; quiz 469-70. 2008
  2. ncbi An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases
    David E Griffith
    Am J Respir Crit Care Med 175:367-416. 2007
  3. ncbi General considerations for lung function testing
    M R Miller
    University Hospital Birmingham NHS Trust, UK
    Eur Respir J 26:153-61. 2005
  4. doi Potential significance of telocytes in the pathogenesis of lung diseases
    Yonghua Zheng
    Zhongshan Hospital, Fudan University, Shanghai, China
    Expert Rev Respir Med 6:45-9. 2012
  5. doi Probiotics and lung diseases
    Paul Forsythe
    Brain Body Institute and Department of Medicine, McMaster University, Hamilton, ON, Canada
    Chest 139:901-8. 2011
  6. ncbi Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease
    C Arden Pope
    Brigham Young University, 130 FOB, Provo, UT 84602 2363, USA
    Circulation 109:71-7. 2004
  7. pmc Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters
    Andrea Ventura
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 132:875-86. 2008
  8. pmc Requirement of bic/microRNA-155 for normal immune function
    Antony Rodriguez
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Science 316:608-11. 2007
  9. ncbi Rapid increase of non-tuberculous mycobacterial lung diseases at a tertiary referral hospital in South Korea
    Y S Park
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
    Int J Tuberc Lung Dis 14:1069-71. 2010
  10. doi Sex steroid receptors in human lung diseases
    Mohit K Verma
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Miyagi ken, Japan
    J Steroid Biochem Mol Biol 127:216-22. 2011

Detail Information

Publications333 found, 100 shown here

  1. pmc Oxidants and the pathogenesis of lung diseases
    Jonathan Ciencewicki
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Allergy Clin Immunol 122:456-68; quiz 469-70. 2008
  2. ncbi An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases
    David E Griffith
    Am J Respir Crit Care Med 175:367-416. 2007
  3. ncbi General considerations for lung function testing
    M R Miller
    University Hospital Birmingham NHS Trust, UK
    Eur Respir J 26:153-61. 2005
  4. doi Potential significance of telocytes in the pathogenesis of lung diseases
    Yonghua Zheng
    Zhongshan Hospital, Fudan University, Shanghai, China
    Expert Rev Respir Med 6:45-9. 2012
    Multiple cells play critical roles in the pathogenesis of lung diseases, even though the exact mechanisms are still not clear...
  5. doi Probiotics and lung diseases
    Paul Forsythe
    Brain Body Institute and Department of Medicine, McMaster University, Hamilton, ON, Canada
    Chest 139:901-8. 2011
  6. ncbi Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease
    C Arden Pope
    Brigham Young University, 130 FOB, Provo, UT 84602 2363, USA
    Circulation 109:71-7. 2004
    ..Associations with specific cardiopulmonary diseases might be useful in exploring potential mechanistic pathways linking exposure and mortality...
  7. pmc Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters
    Andrea Ventura
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 132:875-86. 2008
    ..These results provide key insights into the physiologic functions of this family of microRNAs and suggest a link between the oncogenic properties of miR-17 approximately 92 and its functions during B lymphopoiesis and lung development...
  8. pmc Requirement of bic/microRNA-155 for normal immune function
    Antony Rodriguez
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Science 316:608-11. 2007
    ..Our work suggests that bic/microRNA-155 plays a key role in the homeostasis and function of the immune system...
  9. ncbi Rapid increase of non-tuberculous mycobacterial lung diseases at a tertiary referral hospital in South Korea
    Y S Park
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
    Int J Tuberc Lung Dis 14:1069-71. 2010
    ..From 2002 to 2008, the number of patients with NTM lung diseases increased from 82 to 133, while the number of TB patients decreased from 436 to 276...
  10. doi Sex steroid receptors in human lung diseases
    Mohit K Verma
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Miyagi ken, Japan
    J Steroid Biochem Mol Biol 127:216-22. 2011
    ..studies have reported that gender differences exist in clinical and biological manifestations of human lung diseases. In particular, women are far more likely to develop both neoplastic and non-neoplastic lung diseases than men...
  11. pmc Asbestos-induced lung diseases: an update
    David W Kamp
    Department of Medicine, Northwestern University Feinberg School of Medicine and Jesse Brown VA Medical Center, Chicago, Ill 60611 3010, USA
    Transl Res 153:143-52. 2009
    ..Despite a dramatic reduction in asbestos use worldwide, asbestos-induced lung diseases remain a substantial health concern primarily because of the vast amounts of fibers that have been mined, ..
  12. pmc Nontuberculous mycobacterial lung disease prevalence at four integrated health care delivery systems
    D Rebecca Prevots
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Respir Crit Care Med 182:970-6. 2010
    ..Single-site clinic-based studies suggest an increasing prevalence of pulmonary nontuberculous mycobacteria (NTM) disease, but systematic data are lacking...
  13. pmc The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles
    Ning Li
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, CA 90095, USA
    Free Radic Biol Med 44:1689-99. 2008
    ..The importance of cellular antioxidant and detoxification pathways in protecting against particle-induced lung damage will also be discussed...
  14. ncbi Oxidative stress, chromatin remodeling and gene transcription in inflammation and chronic lung diseases
    Irfan Rahman
    Respiratory Medicine, ELEGI Laboratory, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
    J Biochem Mol Biol 36:95-109. 2003
    Inflammatory lung diseases are characterized by chronic inflammation and oxidant/antioxidant imbalance...
  15. pmc Stem cells and cell therapies in lung biology and lung diseases
    Daniel J Weiss
    Vermont Lung Center, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Proc Am Thorac Soc 8:223-72. 2011
    ..the Pulmonary Fibrosis Foundation, convened a workshop,‘‘Stem Cells and Cell Therapies in Lung Biology and Lung Diseases,’’ held July 26-29, 2009 at the University of Vermont,to review the current understanding of the role of ..
  16. doi Pulmonary nontuberculous mycobacterial disease prevalence and clinical features: an emerging public health disease
    Kevin L Winthrop
    Oregon Health and Science University, Portland, OR 97239, USA
    Am J Respir Crit Care Med 182:977-82. 2010
    ..Respiratory specimens with nontuberculous mycobacteria (NTM) are increasingly common; however, pulmonary disease prevalence is unknown...
  17. doi Pseudomonas aeruginosa: host defence in lung diseases
    Bryan J Williams
    Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Respirology 15:1037-56. 2010
    ..Understanding the pathogenesis of P. aeruginosa, and the respiratory host defence response to it has, and will continue to, lead to novel therapeutic strategies to help patients...
  18. ncbi Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association
    Robert D Brook
    Circulation 109:2655-71. 2004
    ..Practical recommendations for healthcare providers and their patients are outlined. In the final section, suggestions for future research are made to address a number of remaining scientific questions...
  19. doi A therapeutic role for matrix metalloproteinase inhibitors in lung diseases?
    R E Vandenbroucke
    Dept for Molecular Biomedical Research, VIB, Ghent University, Ghent Zwijnaarde, Belgium
    Eur Respir J 38:1200-14. 2011 the development of pulmonary diseases such as chronic obstructive pulmonary disease, asthma, interstitial lung diseases and lung cancer...
  20. ncbi Very low birth weight outcomes of the National Institute of Child health and human development neonatal research network, January 1995 through December 1996. NICHD Neonatal Research Network
    J A Lemons
    Indiana University, Indianapolis, Indiana, USA
    Pediatrics 107:E1. 2001
    ..To determine the mortality and morbidity for infants weighing 401 to 1500 g (very low birth weight [VLBW]) at birth by gestational age, birth weight, and gender...
  21. pmc Stem cells and cell therapies in lung biology and lung diseases
    Daniel J Weiss
    Department of Medicine, University of Vermont College of Medicine, 149 Beaumont Avenue, HSRF 226, Burlington, VT 05405, USA
    Proc Am Thorac Soc 5:637-67. 2008
  22. pmc Retrospective evaluation of the clinical and radiographic risk factors associated with severe pulmonary hemorrhage in first-line advanced, unresectable non-small-cell lung cancer treated with Carboplatin and Paclitaxel plus bevacizumab
    Alan B Sandler
    Vanderbilt University, Nashville, TN, USA
    J Clin Oncol 27:1405-12. 2009
    ..Retrospective case-control and cohort analyses were conducted to identify associated radiographic and clinical risk factors for PH...
  23. doi Characteristics of pulmonary cysts in Birt-Hogg-Dubé syndrome: thin-section CT findings of the chest in 12 patients
    Kazunori Tobino
    Department of Respiratory Medicine, Juntendo University, School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Eur J Radiol 77:403-9. 2011
    ..To describe in detail the characteristic chest computed tomography (CT) findings of Birt-Hogg-Dubé (BHD) syndrome...
  24. doi Pulmonary cysts of Birt-Hogg-Dubé syndrome: a clinicopathologic and immunohistochemical study of 9 families
    Mitsuko Furuya
    Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Am J Surg Pathol 36:589-600. 2012
    ..We propose a new insight, namely, that the BHD syndrome-associated pulmonary cyst may be considered a hamartoma-like cystic alveolar formation associated with deranged mTOR signaling...
  25. pmc Isolation prevalence of pulmonary non-tuberculous mycobacteria in Ontario, 1997 2003
    Theodore K Marras
    Joint Division of Respirology, University Health Network and Mount Sinai Hospital, Department of Medicine, University of Toronto, Toronto, Canada
    Thorax 62:661-6. 2007
    ..A study was undertaken of the "isolation prevalence" of pulmonary NTM in Ontario, Canada between 1997 and 2003 and the frequency of pulmonary NTM "disease"...
  26. ncbi Vascular endothelial growth factor in the lung
    Norbert F Voelkel
    University of Colorado Health Sciences Center, Pulmonary and Critical Care Division, 4200 E Ninth Ave, C272, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 290:L209-21. 2006
    ..of this protein, there is increasing evidence that VEGF also plays a role in several acute and chronic lung diseases, such as acute lung injury, severe pulmonary hypertension, and emphysema...
  27. doi Lung diseases directly associated with rheumatoid arthritis and their relationship to outcome
    Y Tsuchiya
    Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, 1696 Itai, Kumagaya, Saitama 360 0105, Japan
    Eur Respir J 37:1411-7. 2011
    ..3%) died, of whom 58 (81.7%) died due to respiratory lesions. Of patients with RA-LD, patients with DAD experienced the highest mortality, and the survival of patients with UIP was worse than that of patients with NSIP...
  28. ncbi Lung diseases at necropsy in African children dying from respiratory illnesses: a descriptive necropsy study
    Chifumbe Chintu
    University of Zambia University College London Medical School Research and Training Project, University Teaching Hospital, Lusaka, Zambia
    Lancet 360:985-90. 2002
    ..We undertook a study of children who died from respiratory diseases at University Teaching Hospital, Lusaka, Zambia...
  29. ncbi NRAMP1 gene polymorphism and susceptibility to nontuberculous mycobacterial lung diseases
    Won Jung Koh
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong, Gangnam Gu, Seoul 135 710, South Korea
    Chest 128:94-101. 2005
    ..The purpose of this study was to evaluate a potential role for natural-resistance-associated macrophage protein 1 (NRAMP1) gene polymorphisms for human susceptibility to the NTM lung disease...
  30. pmc Claudins in lung diseases
    Ylermi Soini
    Department of Pathology and Forensic Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, School of Medicine, University of Eastern Finland, Cancer Center of Eastern Finland, PO Box 1627, FI 70211 Kuopio, Finland
    Respir Res 12:70. 2011
    ..In this review, the significance of claudins is discussed in lung disease and development...
  31. doi Antibiotic treatment of Mycobacterium abscessus lung disease: a retrospective analysis of 65 patients
    Kyeongman Jeon
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Am J Respir Crit Care Med 180:896-902. 2009
    ..The optimal therapeutic regimen and duration of treatment for Mycobacterium abscessus lung disease is not well established...
  32. ncbi Long-term morbidity from severe pneumonia in early childhood in The Gambia, West Africa: a follow-up study
    L M Puchalski Ritchie
    University Health Network, University of Toronto, Toronto, Ontario, Canada
    Int J Tuberc Lung Dis 13:527-32. 2009
    ..To assess long-term outcomes in severe early childhood pneumonia in The Gambia...
  33. pmc Chronic lung disease in adolescents with delayed diagnosis of vertically acquired HIV infection
    Rashida A Ferrand
    Clinical Research Department, London School of Hygiene and Tropical Medicine, United Kingdom
    Clin Infect Dis 55:145-52. 2012
    ..Chronic respiratory symptoms are more common than would be anticipated based on the HIV literature...
  34. ncbi Genetic modifiers of lung disease in cystic fibrosis
    Mitchell L Drumm
    Department of Pediatrics, Case Western Reserve University, Cleveland, USA
    N Engl J Med 353:1443-53. 2005
    ..Polymorphisms in genes other than the cystic fibrosis transmembrane conductance regulator (CFTR) gene may modify the severity of pulmonary disease in patients with cystic fibrosis...
  35. pmc Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function
    Dana B Hancock
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Nat Genet 42:45-52. 2010
    ..Our findings may offer insights into pulmonary function and pathogenesis of chronic lung disease...
  36. doi The inflammasome in lung diseases
    Gimena Dos Santos
    Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Am J Physiol Lung Cell Mol Physiol 303:L627-33. 2012
    ..The aim of this review is to summarize the most relevant points of inflammasome activation in lung diseases.
  37. doi Association between long-term exposure to outdoor air pollution and mortality in China: a cohort study
    Jie Cao
    Cardiovascular Institute and Fu Wai Hospital of the Chinese Academy of Medical Sciences and Peking Union Medical College, and Chinese National Center for Cardiovascular Disease Control and Research, Beijing, China
    J Hazard Mater 186:1594-600. 2011
    ..These data contribute to the scientific literature on long-term effects of air pollution for high exposure settings typical in developing countries...
  38. ncbi Reactive oxygen species, inflammation, and lung diseases
    Di Paola Rosanna
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Via C Valeria Gazzi 98100 Messina, Italy
    Curr Pharm Des 18:3889-900. 2012 conceivable that chronic inflammation-induced production of ROS in the lung may predispose individuals to lung diseases. In this review, we discuss mechanisms of oxidant stress in the lung, the role of oxidants in lung disease ..
  39. ncbi Cytokines in tolerance to hyperoxia-induced injury in the developing and adult lung
    Vineet Bhandari
    Divison of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Free Radic Biol Med 41:4-18. 2006
    ..Designing a therapeutic approach to counteract oxygen toxicity in the adult and immature lung first needs understanding of the unique responses in each scenario...
  40. ncbi Augmented responses to ozone in obese carboxypeptidase E-deficient mice
    Richard A Johnston
    Physiology Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115 6021, USA
    Am J Physiol Regul Integr Comp Physiol 290:R126-33. 2006
    ..These results also suggest that chronic systemic inflammation may enhance airway responses to O3 in obese mice...
  41. ncbi Cost-effectiveness analysis of prophylactic respiratory physiotherapy in pulmonary lobectomy
    Gonzalo Varela
    Section of Thoracic Surgery, Salamanca University Hospital, 37007 Salamanca, Spain
    Eur J Cardiothorac Surg 29:216-20. 2006
    ..To evaluate the cost-effectiveness balance of implementing an intensive program of chest physiotherapy in pulmonary lobectomy...
  42. ncbi Pseudomonas aeruginosa mutations in lasI and rhlI quorum sensing systems result in milder chronic lung infection
    H Wu
    Department of Clinical Microbiology, 9301 Rigshospitalet, Juliane Maries Vej 22, DK-2100, , Denmark
    Microbiology 147:1105-13. 2001
    ..The conclusion of this study is that functional lasI and rhlI genes of P. aeruginosa PAO1 play a significant role during lung infection...
  43. pmc Previous lung diseases and lung cancer risk: a systematic review and meta-analysis
    Darren R Brenner
    Samuel Lunenfeld Research Institute of Mount Sinai Hospital, and the Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
    PLoS ONE 6:e17479. 2011
    In order to review the epidemiologic evidence concerning previous lung diseases as risk factors for lung cancer, a meta-analysis and systematic review was conducted.
  44. ncbi Pathology and pathophysiology of pulmonary manifestations in leptospirosis
    Marisa Dolhnikoff
    Department of Pathology, School of Medicine, University of Sao Paulo, SP, Brazil
    Braz J Infect Dis 11:142-8. 2007
    ..In this review we present the main clinical and pathological manifestations of pulmonary involvement in leptospirosis, with special focus on recent data concerning the pathophysiological mechanisms underlying lung injury...
  45. ncbi Postnatal steroids to treat or prevent chronic lung disease in preterm infants
    David J Burchfield
    Pediatrics 111:221-2; author reply 221-2. 2003
  46. pmc IP-10 detection in urine is associated with lung diseases
    Angela Cannas
    Department of Epidemiology and Preclinical Research, L Spallanzani National Institute for Infectious Diseases INMI, Rome, Italy
    BMC Infect Dis 10:333. 2010
    ..In a subgroup, the evaluation was also performed during TB treatment and at therapy completion. Patients with lung diseases other than TB, and healthy subjects were also enrolled.
  47. ncbi Pulmonary Langerhans' cell histiocytosis: molecular analysis of clonality
    S A Yousem
    Departments of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Am J Surg Pathol 25:630-6. 2001
    ..Cigarette smoking may be the stimulus for pulmonary LCH in contrast to other forms of LCH...
  48. pmc Wnt signalling in lung development and diseases
    Judit E Pongracz
    Department of Immunology and Biotechnology, University of Pecs, Pecs, Hungary
    Respir Res 7:15. 2006
    ..In this review, we will present a synopsis of current Wnt research with particular attention paid to the role of Wnt signals in lung development and in pulmonary diseases...
  49. ncbi Leptospirosis presenting as diffuse alveolar hemorrhage: case report and literature review
    Andrew M Luks
    Department of Medicine Dr Luks, University of Washington, Seattle 98108, USA
    Chest 123:639-43. 2003
    ..In the right clinical scenario, the disease should be considered in a patient presenting with diffuse alveolar hemorrhage...
  50. ncbi Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice
    E Hummler
    Institut de Pharmacologie et de Toxicologie de l Université, Lausanne, Switzerland
    Nat Genet 12:325-8. 1996
    ..Alpha-ENaC(-/-) neonates developed respiratory distress and died within 40 h of birth from failure to clear their lungs of liquid. This study shows that ENaC plays a critical role in the adaptation of the newborn lung to air breathing...
  51. pmc Guidelines for radiologically guided lung biopsy
    A Manhire
    Department of Radiology, Nottingham City Hospital, UK
    Thorax 58:920-36. 2003
  52. ncbi Early pulmonary involvement in ankylosing spondylitis: assessment with thin-section CT
    K Turetschek
    Department of Radiology, University of Vienna, Austria
    Clin Radiol 55:632-6. 2000
  53. ncbi Inhaled hypertonic saline as a therapy for cystic fibrosis
    Mark R Elkins
    Royal Prince Alfred Hospital, Australia
    Curr Opin Pulm Med 12:445-52. 2006
    ..At that time, competing hypotheses about the pathogenesis of cystic fibrosis lung disease predicted very different responses to long-term inhalation of hypertonic saline...
  54. ncbi Pneumothorax in pulmonary Langerhans cell histiocytosis
    Jose L Mendez
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Chest 125:1028-32. 2004
    ..Pulmonary Langerhans cell histiocytosis (PLCH) is a smoking-related interstitial lung disease characterized by development of cystic changes that predispose to occurrence of pneumothorax...
  55. ncbi Prevalence and clinical significance of antineutrophil cytoplasmic antibodies in Churg-Strauss syndrome
    Renato A Sinico
    Dipartimento di Nefrologia e Immunologia, Azienda Ospedaliera Ospedale San Carlo Borromeo, Milan, Italy
    Arthritis Rheum 52:2926-35. 2005
    ..We undertook this study to examine the prevalence and antigen specificity of ANCAs in a large cohort of patients with CSS. Moreover, we evaluated the relationship between ANCA positivity and clinicopathologic features...
  56. ncbi Pulmonary alveolar microlithiasis: report on 576 cases published in the literature
    Salvatore Mariotta
    Dipartimento Scienze Cardiovascolare e Respiratorie, Universita La Sapienza, Azienda Policlinico Sant Andrea, UO Pneumologia, and Italy
    Sarcoidosis Vasc Diffuse Lung Dis 21:173-81. 2004
    ..The present paper aimed to study the disorder throughout the world, emphasizing the diagnostic and therapeutic views...
  57. doi Impact of oxidative stress on lung diseases
    Hee Sun Park
    Department of Internal Medicine, Chungnam National University Medical School, Daejeon, Korea
    Respirology 14:27-38. 2009
    ..Knowledge of the mechanisms of ROS regulation could lead to the pharmacological manipulation of antioxidants in lung inflammation and injury...
  58. ncbi The relationship between reduced lung function and cardiovascular mortality: a population-based study and a systematic review of the literature
    Don D Sin
    Department of Medicine, Respiratory Division, University of British Columbia, and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada
    Chest 127:1952-9. 2005
    ..We sought to determine the relationship between reduced FEV1 and cardiovascular mortality, independent of smoking...
  59. doi Birt-Hogg-Dubé syndrome: diagnosis and management
    Fred H Menko
    Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands
    Lancet Oncol 10:1199-206. 2009
    ..Preventive measures are aimed mainly at early diagnosis and treatment of renal cancer. This Review gives an overview of current diagnosis and management of BHD...
  60. ncbi The challenge of patients' unmet palliative care needs in the final stages of chronic illness
    D Fitzsimons
    Nursing Research and Development, Belfast City Hospital, Belfast, Northern Ireland
    Palliat Med 21:313-22. 2007
    ..There is consensus in the literature that the end of life care for patients with chronic illness is suboptimal, but research on the specific needs of this population is limited...
  61. doi Pseudomonas aeruginosa recognizes and responds aggressively to the presence of polymorphonuclear leukocytes
    Morten Alhede
    Department of Systems Biology, Technical University of Denmark, DK 2800 Lyngby, Denmark
    Microbiology 155:3500-8. 2009
    ..Our data strengthen the view that cross-kingdom communication plays a key role in P. aeruginosa recognition and evasion of the host defence...
  62. pmc Advances in neutrophil biology: clinical implications
    Andrew S Cowburn
    Respiratory Medicine Division, Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Chest 134:606-12. 2008
    Many lung diseases are characterized by neutrophil-dominated inflammation; therefore, an understanding of neutrophil function is of considerable importance to respiratory physicians...
  63. ncbi Rheumatoid arthritis-related lung diseases: CT findings
    Nobuyuki Tanaka
    Department of Radiology, University of Colorado Health Sciences Center, Denver, CO, USA
    Radiology 232:81-91. 2004
    ..To evaluate computed tomographic (CT) findings of rheumatoid arthritis-related lung disease and categorize findings according to pathologic features...
  64. ncbi Significant involvement of CCL2 (MCP-1) in inflammatory disorders of the lung
    C Edward Rose
    Division of Pulmunory and Critical Care Medicine and the Division of Rheumatology and Immunology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Microcirculation 10:273-88. 2003
  65. ncbi Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation
    Chiu wing Lam
    Space and Life Sciences, NASA Johnson Space Center, Houston, Texas 77058, USA
    Toxicol Sci 77:126-34. 2004
  66. doi Lung cysts in Birt-Hogg-Dubé syndrome: histopathological characteristics and aberrant sequence repeats
    Shunsuke Koga
    Department of Pathology, Chiba University Hospital, Chiba, Japan
    Pathol Int 59:720-8. 2009
    ..Haploinsufficiency of folliculin may cause deranged alveolar development, leading to the aberrant cystic alveolar formation. The unique mutation patterns of abnormal sequence repeats in patients with BHD syndrome are also reviewed...
  67. pmc Integrating microRNAs into a system biology approach to acute lung injury
    Tong Zhou
    Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Illinois at Chicago, Chicago, Ill, USA
    Transl Res 157:180-90. 2011
    ..VILI) and the more severe acute respiratory distress syndrome (ARDS), are common and complex inflammatory lung diseases potentially affected by various genetic and nongenetic factors...
  68. ncbi Nontuberculous mycobacteria in non-HIV patients: epidemiology, treatment and response
    M T Henry
    Dept of Respiratory Medicine, Leeds General Infirmary, Leeds, UK
    Eur Respir J 23:741-6. 2004
    ..Nontuberculous mycobacteria infections remain a significant problem in non-HIV patients. Adherence to published guidelines may improve patient outcomes...
  69. ncbi Vascular endothelial growth factor and related molecules in acute lung injury
    Marco Mura
    Thoracic Surgery Research Laboratories, Toronto Generl Research Institute, University Health Network, Toronto, Ontario, Canada M5G 2C4
    J Appl Physiol (1985) 97:1605-17. 2004
    ..Understanding the role of VEGF in this disease process is crucial for developing new therapeutic strategies for ALI/ARDS...
  70. ncbi Preoperative pulmonary risk stratification for noncardiothoracic surgery: systematic review for the American College of Physicians
    Gerald W Smetana
    Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann Intern Med 144:581-95. 2006
    ..The importance of clinical risk factors for postoperative pulmonary complications and the value of preoperative testing to stratify risk are the subject of debate...
  71. doi Surfactant-replacement therapy for respiratory distress in the preterm and term neonate
    William A Engle
    Pediatrics 121:419-32. 2008
  72. doi Phosphodiesterase-4 inhibitor therapy for lung diseases
    Bianca Beghe
    Section of Respiratory Diseases, Department of Oncology, Haematology, and Respiratory Diseases, University of Modena and Reggio Emilia, Policlinico di Modena, Modena, Italy
    Am J Respir Crit Care Med 188:271-8. 2013 highly expressed in leukocytes and other inflammatory cells involved in the pathogenesis of inflammatory lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD), inhibition of PDE4 has been predicted to ..
  73. doi Co-morbidities in established rheumatoid arthritis
    Nicola J Gullick
    Department of Rheumatology, King s College London School of Medicine, Weston Education Centre, United Kingdom
    Best Pract Res Clin Rheumatol 25:469-83. 2011
  74. doi Therapeutic modulation of miRNA for the treatment of proinflammatory lung diseases
    Tidi Hassan
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    Expert Rev Anti Infect Ther 10:359-68. 2012
    ..of aspects of innate immunity and inflammation, what happens when this goes awry, such as in the chronic inflammatory lung diseases cystic fibrosis and asthma, and discuss the current state-of-the-art miRNA-targeted therapeutics.
  75. doi Application of 'omics technologies to biomarker discovery in inflammatory lung diseases
    Craig E Wheelock
    Division of Physiological Chemistry II, Karolinska Institutet, Stockholm
    Eur Respir J 42:802-25. 2013
    Inflammatory lung diseases are highly complex in respect of pathogenesis and relationships between inflammation, clinical disease and response to treatment...
  76. pmc Molecular basis of asbestos-induced lung disease
    Gang Liu
    Clinical Research Center, Affiliated Hospital of Guangdong Medical College, Zhangjiang, China
    Annu Rev Pathol 8:161-87. 2013
    ..These new insights into the molecular basis of asbestos-induced lung diseases may foster the development of novel therapeutic targets for managing degenerative diseases (e.g...
  77. pmc Clinical application of exhaled nitric oxide measurement in pediatric lung diseases
    Angelo Manna
    Department of Pediatrics, Federico II University, Naples, Italy
    Ital J Pediatr 38:74. 2012
    ..This review focuses on the most recent advances and the current clinical applications of FeNO measurement in pediatric lung disease...
  78. doi Immune receptors and adhesion molecules in human pulmonary leptospirosis
    Fabiola Del Carlo Bernardi
    Department of Pathology, University of Sao Paulo Medical School, São Paulo SP CEP 01246 903, Brazil
    Hum Pathol 43:1601-10. 2012
    ..015). Our results indicate that immune receptors and adhesion molecules participate in the phenomena leading to pulmonary hemorrhage in leptospirosis...
  79. doi Perspectives for improving the evaluation and access of therapies for rare lung diseases in Europe
    Maurizio Luisetti
    Department of Molecular Medicine, Section of Pneumology, University of Pavia, IRCCS San Matteo Hospital Foundation, Pavia, Italy
    Respir Med 106:759-68. 2012
    ..Small patient cohorts alter clinical trial design and limit enrollment, and the picture for rare lung diseases is further complicated by the fact that most are composed of a variety of clinical phenotypes...
  80. ncbi Serum anti-p53 autoantibodies in pleural malignant mesothelioma, lung cancer and non-neoplastic lung diseases
    Monica Neri
    Division of Environmental Epidemiology, National Cancer Research Institute, Largo Rosanna Benzi 10, I 16132 Genoa, Italy
    Lung Cancer 39:165-72. 2003
    ..The longer survival among positive LC patients and the presence of two seropositive among patients with non-neoplastic respiratory diseases should be further investigated...
  81. pmc Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis
    Ayse Corut
    Department of Molecular Biology and Genetics, Bogazici University, Istanbul, Turkey
    Am J Hum Genet 79:650-6. 2006
    ..In 2 of the 15 subjects with TM we studied, we identified two rare variants, one synonymous and the other noncoding, that are possibly associated with the condition...
  82. ncbi Clinical practice. The solitary pulmonary nodule
    David Ost
    Center for Pulmonary and Critical Care Medicine, North Shore University Hospital, Manhasset, NY 11030, USA
    N Engl J Med 348:2535-42. 2003
  83. ncbi The emerging role of endothelial progenitor cells in pulmonary hypertension and diffuse lung diseases
    Gian Paolo Fadini
    University of Padua, Department of Clinical and Experimental Medicine, Italy
    Sarcoidosis Vasc Diffuse Lung Dis 24:85-93. 2007 of many organs and tissues has provided new perspectives for the comprehension of the pathogenesis of lung diseases. Endothelial progenitor cells (EPCs) provide a circulating pool of cells for maintenance of the systemic and ..
  84. pmc Chest radiography patterns in 75 adolescents with vertically-acquired human immunodeficiency virus (HIV) infection
    S R Desai
    King s College London, King s Health Partners, Department of Radiology, King s College Hospital NHS Foundation Trust, UK
    Clin Radiol 66:257-63. 2011
    ..To evaluate lung disease on chest radiography (CR), the relative frequency of CR abnormalities, and their clinical correlates in adolescents with vertically-acquired human immunodeficiency virus (HIV) infection...
  85. doi Unusual presentation: pulmonary hemosiderosis with celiac disease and retinitis pigmentosa in a child
    Ozlem Keskin
    Pediatric Allergy and Immunology Unit, Medical Faculty, Gaziantep University, Gaziantep, Turkey
    Pediatr Pulmonol 46:820-3. 2011
    ..We report a 9-year-old boy with Lane-Hamilton syndrome, co-occurrence of pulmonary hemosiderosis with CD. This presentation is unique presentation because he has also retinal pigmentation...
  86. doi Nitrative stress in inflammatory lung diseases
    Hisatoshi Sugiura
    Third Department of Internal Medicine, Wakayama Medical University School of Medicine, 811 1 Kimiidera, Wakayama, Wakayama 641 0012, Japan
    Nitric Oxide 25:138-44. 2011
    ..NO derived from the inducible type of NOS (iNOS, NOS2) in airway and lung inflammation in inflammatory lung diseases including bronchial asthma and chronic obstructive pulmonary disease (COPD) are controversial...
  87. ncbi Lung disease and PKCs
    Edward C Dempsey
    Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Pharmacol Res 55:545-59. 2007
    ..Key isotypes of PKC involved in lung pathophysiology are summarized and current and evolving therapeutic approaches to target them are identified...
  88. ncbi Nrf2 defends the lung from oxidative stress
    Hye Youn Cho
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Antioxid Redox Signal 8:76-87. 2006
  89. doi Diffuse cystic lung disease of unexplained cause with coexistent small airway disease: a possible causal relationship?
    Camilla Rowan
    Department of Histopathology, Royal Brompton Hospital, London, UK
    Am J Surg Pathol 36:228-34. 2012
    ..The driving factor remains unknown...
  90. doi The rabbit as a model to study asthma and other lung diseases
    Sandra Keir
    Sackler Institute of Pulmonary Pharmacology, Division of Pharmaceutical Sciences, 5th Floor Hodgkin Building, King s College London, Guy s Campus, London SE1 9RT, UK
    Pulm Pharmacol Ther 21:721-30. 2008
    ..This article highlights the usefulness of the rabbit as a species to study lung biology...
  91. doi Indoor air pollution from solid fuel use, chronic lung diseases and lung cancer in Harbin, Northeast China
    Carlotta Galeone
    Istituto di Ricerche Farmacologiche Mario Negri, 19 20156 Milan, Italy
    Eur J Cancer Prev 17:473-8. 2008
    ..We analyzed the relationship between IAP from solid fuel use and selected chronic lung diseases and lung cancer risk in Harbin, Northeast China, an area with a very high base line risk of lung cancer for ..
  92. doi Stem cell treatment for chronic lung diseases
    Argyris Tzouvelekis
    Department of Pneumonology, University Hospital of Alexandroupolis, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
    Respiration 85:179-92. 2013
    Chronic lung diseases such as idiopathic pulmonary fibrosis and cystic fibrosis or chronic obstructive pulmonary disease and asthma are leading causes of morbidity and mortality worldwide with a considerable human, societal and financial ..
  93. doi Leptospirosis pulmonary haemorrhage syndrome is associated with linear deposition of immunoglobulin and complement on the alveolar surface
    J Croda
    Laboratory of Pathology of Transmissible Diseases, Department of Pathology, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil
    Clin Microbiol Infect 16:593-9. 2010
    ..In the present study, it was found that the linear deposition of immunoglobulins (IgA, IgG and IgM) and complement on the alveolar surface may play a role in the pathogenesis of pulmonary haemorrhage in human leptospirosis...
  94. doi Epigenetics in asthma and other inflammatory lung diseases
    Andrew Durham
    Airways Disease Section, National Heart and Lung Institute, Imperial College, Dovehouse Street, London, SW3 6LY, UK
    Epigenomics 2:523-37. 2010
    Asthma is a chronic inflammatory disease of the airways. The causes of asthma and other inflammatory lung diseases are thought to be both environmental and heritable...
  95. doi Pulmonary features of Birt-Hogg-Dubé syndrome: cystic lesions and pulmonary histiocytoma
    S Tomassetti
    Pulmonary Medicine, GB Morgagni Hospital, Forli, Italy
    Respir Med 105:768-74. 2011 describe clinical, radiologic and pathologic features of lung lesions in Birt-Hogg-Dubè syndrome (BHDS) (MIM 135150)...
  96. doi SLPI and trappin-2 as therapeutic agents to target airway serine proteases in inflammatory lung diseases: current and future directions
    Marie Louise Zani
    INSERM U618, Protéases et Vectorisation Pulmonaires, Faculte de Medecine, 10 Bd Tonnellé, 37032 Tours Cedex, France
    Biochem Soc Trans 39:1441-6. 2011 examines the multifaceted roles of SLPI and elafin/trappin-2 in the context of their possible use as inhaled drugs for treating chronic lung diseases such as CF (cystic fibrosis) and COPD (chronic obstructive pulmonary disease).
  97. pmc Computer-assisted detection of infectious lung diseases: a review
    Ulas Bagci
    Center for Infectious Disease Imaging, Department of Radiology and Imaging Sciences, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Comput Med Imaging Graph 36:72-84. 2012
    ..In this paper, we review the most common radiographic and CT features of respiratory tract infections, discuss the challenges of defining and measuring these disorders with CAD, and propose some strategies to address these challenges...
  98. doi Clinical characteristics and prognosis of nontuberculous mycobacterial lung disease with different radiographic patterns
    Chin Chung Shu
    Department of Traumatology, Taiwan University Hospital, Taipei, Taiwan
    Lung 189:467-74. 2011
    ..The clinical characteristics and prognostic impact of radiographic patterns of patients with nontuberculous mycobacterial lung disease (NTM-LD) are rarely evaluated...
  99. doi Early extracorporeal life support as rescue for Wegener granulomatosis with diffuse alveolar hemorrhage and acute respiratory distress syndrome: a case report and literature review
    Mark Joseph
    Division of Trauma and Critical Care Surgery, Department of Surgery, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599 7228, USA
    Pediatr Emerg Care 27:1163-6. 2011
    ..The study's objective was to report a case and review the literature on the use of extracorporeal life support in the face of severe pulmonary hemorrhage for acute respiratory distress syndrome...
  100. doi Pulmonary and thrombotic manifestations of systemic lupus erythematosus
    Jeffrey J Swigris
    Autoimmune Lung Disease Center, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 133:271-80. 2008
    ..This article offers the reader a comprehensive review of the numerous pulmonary and thrombotic manifestations of SLE and suggests approaches to their management...
  101. pmc Blood transfusion during cardiac surgery is associated with inflammation and coagulation in the lung: a case control study
    Pieter R Tuinman
    Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Meibergdreef 9, Amsterdam NL 1105 AZ, The Netherlands
    Crit Care 15:R59. 2011
    ..We hypothesized that blood transfusion is associated with changes in pulmonary and systemic inflammation and coagulation occurring in patients who do not meet the clinical diagnosis of transfusion-related acute lung injury (TRALI)...

Research Grants72

  1. Regulation of mural cells during pulmonary capillary formation
    Stephen E McGowan; Fiscal Year: 2013
    ..These studies are relevant to other vascular diseases including stroke, diabetes, and chronic renal insufficiency, which are also common among veterans. ..
  2. Lung Lysyl Oxidase Regulation by Metal Ion Homeostasis
    Wande Li; Fiscal Year: 2013
    ..are critical targets for Cd insult and silencing of LO gene transcription by Cd is a key molecular basis for lung diseases. The overall goal of the proposed research is to test this hypothesis by achieving following specific aims: 1) ..
    Pi Wan Cheng; Fiscal Year: 2010
    Mucus hypersecretion is a hallmark of obstructive lung diseases, including chronic bronchitis, asthma, and cystic fibrosis. This condition is the result of hypertrophy and hyperplasia of mucus cells...
  4. Pathobiology of Cystic Fibrosis-Related Diabetes in a Ferret Model
    Zoe Stewart; Fiscal Year: 2013
    ..These results are expected to have a significant positive impact on the field of CF research. ..
  5. Regulation of Airway Mucin Gene Expression by Epigenetic Mechanism
    Reen Wu; Fiscal Year: 2013
    ..mucus accumulation due to mucin overproduction is one of major clinical symptoms associated with various lung diseases, such as asthma, cystic fibrosis, bronchitis, chronic obstructive pulmonary diseases, etc...
  6. Immune Mechanism of Rejection in Human Lung Allografts
    Thalachallour Mohanakumar; Fiscal Year: 2013
    ..We will also identify lung diseases which will pre-dispose for the development of Abs to self-Ags...
  7. Novel Peptide MPO Inhibitors for Treating Atherosclerosis
    Kirkwood A Pritchard; Fiscal Year: 2012
    ..As these disease states represent a major focus of the NIH, findings from our proposal will advance the research and mission of several different institutes. ..
  8. Global regulatory interactions in bacterial pathogenesis
    BRIAN AKERLEY; Fiscal Year: 2009
    ..Immune signaling and effector pathways will be examined to define clearance mechanisms that H. influenzae is able to avoid by modulating its surface structures. ..
  9. Unbiased genome-wide screen to identify genes regulating mucous cell hyperplasia
    Jeffrey A Whitsett; Fiscal Year: 2010
    ..screen to identify compounds and processes regulating mucous cell activity relevant to both acute and chronic lung diseases. Mouse and human Respiratory Epithelial Cells (RECs) will be engineered with genes indicating the activity of ..
  10. Small Molecule targeting of NADPH oxidase in neutrophils
    Marie Dominique Filippi; Fiscal Year: 2010
    ..a novel class of anti-inflammatory drugs specifically targeting neutrophil functions for amelioration of lung diseases including acute lung injury/acute respiratory distress syndrome (ALI/ARDS) and chronic obstructive pulmonary ..
  11. Regulation of Innate and Adaptive Immunity in Human COPD and Emphysema
    Farrah Kheradmand; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Cigarette smoke-related lung diseases is one of the most common causes of disability and death among veterans...
  12. Endotoxin, the airway transcriptome, and obstructive lung disease
    PEGGY SUE LAI; Fiscal Year: 2013 applicant): Research Asthma and chronic obstructive pulmonary disease (COPD) are chronic inflammatory lung diseases that affect an estimated 35 million Americans...
  13. Targeting AP-1 proteins in COPD
    SEKHAR M POTHIREDDY; Fiscal Year: 2010
    ..End of Abstract) ..
  14. Intrathoracic Pressure Regulator for Resuscitation
    Keith G Lurie; Fiscal Year: 2011
    ..As such, this new device has the potential to be an important new advance in treating life-threatening hypotension and thereby reduce civilian and military mortality rates. ..
  15. Impaired mitochondrial fusion in pulmonary arterial hypertension
    Stephen L Archer; Fiscal Year: 2010
    ..Research and specific challenge topic 04-HL-102: Develop Integrative Strategies to Elucidate the Mechanisms of Lung Diseases. Pulmonary arterial hypertension (PAH) is a syndrome characterized by obstructive vascular remodeling, ..
    Irfan Rahman; Fiscal Year: 2013
  17. Novel Macrolide Th17 Inhibitors
    Jay K Kolls; Fiscal Year: 2012
    ..These compounds may improve treatment for chronic lung diseases such as COPD or steroid resistant asthma...
  18. Mechanism Underlying Nitrite Sensitivity of Mucoid Pseudomonas in COPD
    Daniel J Hassett; Fiscal Year: 2013
    ..Improved treatment options, in this case the use of sodium nitrite for the management of COPD exacerbations precipitated by PA infection are needed to reduce mortality and morbidity. ..
  19. A novel telomerase expressing lung fibroblast phenotype
    Sem H Phan; Fiscal Year: 2012
    ..broad long term objective is to elucidate the role of telomerase induction in pathogenesis of chronic fibrotic lung diseases, such as interstitial lung diseases, chronic obstructive pulmonary disease (COPD) and asthma...
  20. Roles of NF-kB/Rel in the pathogenesis of breast cancer
    Gail E Sonenshein; Fiscal Year: 2012
    ..Thus, pre-clinical testing of green tea components on breast cancer cells that are resistant to antibody therapy will be performed, and if successful, this approach can readily be translated to the clinic. ..
  21. Dependency of O-3 Induced Lung Mucus Hypersecretion on NQ01
    W Michael Foster; Fiscal Year: 2010
  22. SARS-CoV Pathogenic Mechanisms in Senescent Mice
    Ralph S Baric; Fiscal Year: 2012
  23. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
    Tobacco related lung diseases, including chronic obstructive pulmonary disease (COPD) with and without emphysema, are among the major causes of lung-related disability and death worldwide...
  24. Local Calcium Signaling in Pulmonary Arteries
    JAMES SK SHAM; Fiscal Year: 2012
    ..The information generated by the proposed experiments will be valuable for the development of new treatments for pulmonary vascular diseases. ..
  25. Tadalafil for Pulmonary Hypertension Associated with Chronic Lung Disease
    SHARON IRENE SMITH ROUNDS; Fiscal Year: 2013
    ..If successful, this treatment option may improve quality of life and outcomes for the large number of veterans afflicted with PH due to COPD. ..
  26. Angiogenesis in the Lung
    Elizabeth Wagner; Fiscal Year: 2010
    ..In an animal model of chronic pulmonary thromboembolic disease, this project will determine the inflammatory cytokines and cells responsible for new vessel growth, and pharmacological and interventional inhibitors. ..
  27. Fate of Lung Stem Cells During Pulmonary Disease
    Susan M Majka; Fiscal Year: 2012
  28. Ibis T-6,000 Biosensor System
    CYNTHIA SEARS; Fiscal Year: 2010
    ..and prostate cancer, progression of liver disease and transplant recipients with rejection and idiopathic lung diseases;2) detection of specific pathogens (Staphylococcus aureus, nosocomial multidrug resistant gram negative rods, ..
  29. IGFBP-5 and Hsp70 in Extracellular Matrix Homeostasis and Fibrosis
    Kristen L Veraldi; Fiscal Year: 2013
    ..RELEVANCE (See instructions): The interstitial lung diseases (ILDs) result in significant morbidity and mortality, and there are no effective medical therapies to reverse ..
  30. The Effects of PP2A on TNF Signaling and Smoke-Induced Lung Injury
    Robert F Foronjy; Fiscal Year: 2013
    ..However, its effects on inflammatory lung diseases such as COPD have not been well studied...
  31. Biomarkers to Assess Selenium Chemoprevention for NSCLC
    Steven A Belinsky; Fiscal Year: 2012
    ..Studies will also assess whether these same biomarkers can predict cancer recurrence. Finally, a cocktail of agents with minimal side effects is being evaluated that could ultimately be used in the prevention of lung cancer in humans. ..
  32. Pulmonary effects of biomass fuel indoor PM from rural India
    Shyam Biswal; Fiscal Year: 2013
    ..from this study will help to develop future strategies for intervention in the rural population to reduce lung diseases. This proposal is an extension of the recently awarded FIRCA Eligible Award "Children's Environmental and ..
  33. Iowa Phase II Clinical Trials of Novel Therapies for Lung Diseases (U01
    Lakshmi Durairaj; Fiscal Year: 2012
    ..Giving xylitol as a nebulizer into the lungs may be a simple and safe way to ward off lung infections. (End of Abstract) ..
  34. Mechanisms and Enviromental Determinants of Rhinovirus Illness Severity
    James E Gern; Fiscal Year: 2013
    ..of lower respiratory illness including bronchiolitis, influenza-like illness, and exacerbations of chronic lung diseases such as asthma, cystic fibrosis, and chronic obstructive lung disease (COPD)...
  35. Research Training in Cardiovascular and Pulmonary Diseases
    S Jamal Mustafa; Fiscal Year: 2012
    ..the National Institute for Occupational Safety &Health (NIOSH), known for its research on inflammation and lung diseases. NIOSH is a research division of the CDC immediately adjacent to the School of Medicine...
  36. Eosinophil ORMDL3 and allergic inflammation
    P Sriramarao; Fiscal Year: 2012
    ..of asthma as well as meet the objectives of NIAID/NHLBI to understand, treat or prevent allergy and lung diseases. PUBLIC HEALTH RELEVANCE: Allergic airway inflammation including asthma affects an estimated 20 million people ..
  37. Epigenetic Alterations in IPF Fibroblastic Foci
    YAN SANDERS; Fiscal Year: 2010
    ..End of Abstract) ..
  38. Mechanisms for Cardiovascular Effects of air pollutants: Effect of Age and Sex
    BRITT HOLMEN; Fiscal Year: 2010 combustion-related fine particulate air pollution is a significant environmental risk factor for heart and lung diseases. Despite numerous studies examining the effects of petroleum diesel (petrodiesel) exhaust emissions on the ..
  39. MNEI/SerpinB1: A modulator of innate pulmonary defense
    EILEEN REMOLD-O'DONNELL; Fiscal Year: 2010
    ..Indeed, mnei, the central molecule under study in the project, is a candidate therapeutic for inflammatory lung disease. ..
  40. Caveolins in the Pathogenesis of Idiopathic Pulmonary Fibrosis
    Dan N Predescu; Fiscal Year: 2010
    ..End of Abstract) ..
  41. Right Heart-Pulmonary Vascular Interactions in Bronchopulmonary Dysplasia
    Marlowe Eldridge; Fiscal Year: 2013
    ..hemodynamics, and scientists investigating the causes and consequences of right ventricular failure in chronic lung diseases. PUBLIC HEALTH RELEVANCE: A too frequent consequence of premature birth is a chronic lung disease known as ..
  42. Regulation of Lung Fibrosis by Alternatively Activated Macrophages and Arginase-1
    ROBERT MATTHEW TIGHE; Fiscal Year: 2013
    ..Research Project: Fibrotic lung diseases are a significant cause of morbidity and mortality for which effective therapies are lacking...
  43. The RAGE of COPD
    John R Hoidal; Fiscal Year: 2013
    ..It will impact our ability to prevent or reduce the enormous medical burden caused by cigarette smoking. Nowhere is the need for new approaches with clinical application more important in pulmonary diseases than in COPD. ..
  44. Neprilysin and Pulmonary Vascular Remodeling: Cellular and Molecular Mechanisms
    EDWARD CHARLES DEMPSEY; Fiscal Year: 2013
  45. Mechanisms of Haemophilus influenzae pathogenesis in the lung
    Hao Shen; Fiscal Year: 2013
    Joseph G Verbalis; Fiscal Year: 2010
  47. Moraxella catarrhalis: virulence-based prevention
    Timothy F Murphy; Fiscal Year: 2013
    ..There is a renewed enthusiasm for vaccines for otitis media given recent promising clinical trials, creating a momentum of feasibility for this approach. ..
  48. Developing a New Antioxidant Activator to Intervene in Lung Inflammatory Diseases
    JOHN WILLIMANN; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: Over 35 million Americans live with acute and chronic lung diseases whose pathology is linked to inflammation...
  49. Genetic Determinants of Lung Injury
    Beverly H Koller; Fiscal Year: 2013
    ..provided by applicant): Oxidative stress has been implicated in the pathogenesis of many acute and chronic lung diseases including asthma and chronic obstructive pulmonary disease (COPD)...
  50. Molecular mechanisms of cytochrome P4501A regulation by hyperoxia
    Bhagavatula Moorthy; Fiscal Year: 2010
    ..our long-term goals, which are the development of rational strategies for the prevention and treatment of lung diseases (e.g. BPD and ARDS) associated with hyperoxia...
  51. Exposure and biological response biomarkers of cigarette smoke
    IAN ALEXANDER BLAIR; Fiscal Year: 2010
  52. Roles of pulmonary and hepatic P4501A enzymes in hyperoxic lung injury in mice
    Bhagavatula Moorthy; Fiscal Year: 2010
    ..The long-term of this proposal is to develop rational strategies for the prevention and/or treatment of chronic lung diseases in infants and adults suffering from respiratory distress and lung dysfunction.
  53. Translational Approaches to Reducing Health Disparities in Lung Disease
    Joe G N Garcia; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Abstract Lung diseases cause an estimated 380,000 deaths annually and account for substantial morbidity in Americans...
  54. Effects of lymphangiogenesis stimulation on lung allograft rejection
    Souheil El-Chemaly; Fiscal Year: 2013
    ..transplantation remains the only therapy proven to prolong survival and improve quality of life in advanced lung diseases such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF)...
  55. Clinical Impact of Human Coronaviruses and Viral Diversity
    Geoffrey J Gorse; Fiscal Year: 2012
    ..HCoV) are associated with a range of respiratory illnesses that affect the status of underlying chronic lung diseases and congestive heart failure...
  56. Role of Microbial Translocation in Cardiopulmonary Disease in Children with HIV
    Alison Morris; Fiscal Year: 2013
    ..Results could translate into new methods to treat or prevent cardiac and pulmonary disease in HIV+ children. ..
    DEBRA LYNN LASKIN; Fiscal Year: 2012
    ..for abrogating tissue injury associated with exposure to inhaled pollutants, as well as episodic inflammatory lung diseases such as asthma...
  58. Statins for Pulmonary and Cardiac Complications of Chronic HIV (The SPARC Trial)
    Stephen R Wisniewski; Fiscal Year: 2013
  59. Counter-Regulation of TLR-Driven Mucosal Inflammation
    Erik P Lillehoj; Fiscal Year: 2010 study the detailed mechanism of action of MUC1 in the pathogenesis of bacterial-induced hyperinflammatory lung diseases such as CF. Mucosal inflammation is an essential host defense mechanism mounted in response to pathogens...
  60. Mechanisms and consequences of sleep disordered breathing in COPD
    Cynthia D Brown; Fiscal Year: 2012
    ..Finally, this research studies a new intervention to determine if it might help to improve sleep quality in COPD. (End of Abstract) ..
  61. Dysregulation of the inflammatory response by Francisella tularensis
    Lee Ann H Allen; Fiscal Year: 2013
  62. Evolutionary Analysis of the Histone Deacetylase Family: Biomedical Research
    JOSEPH LEWIS GRAVES; Fiscal Year: 2011
    ..This in turn has the potential to inform drug development efforts impacting a breadth of specific diseases, as well as general aging itself. ..
  63. Metals in exhaled breath condensate as COPD biomarkers
    Antonio Mutti; Fiscal Year: 2005
    ..abstract_text> ..
  64. Effect of Macrolide Treatment on a Novel Pathway of Neutrophilic Inflammation in
    J Edwin Blalock; Fiscal Year: 2010
    ..This is proposed to underly a possible therapeutic activity in chronic lung diseases such as COPD...
  65. Multiplex TB-M.avium complex Fluorescent in Situ hybridization Assay, direct from
    Jyotsna Shah; Fiscal Year: 2009
    ..2. Has specificity of amplified assays and sensitivity equivalent or better than acid-fast staining. 3. Does not require expensive equipment other than a microscope. 4. From time of receipt of sputum sample to result is about 2 hours. ..
  66. Translating COPD Guidelines inot Primary Care Practice
    Donna Parker; Fiscal Year: 2009
  67. Mechanisms of 5'UTR splicing of human surfactant protein (SP)-A1 and SP-A2
    Guirong Wang; Fiscal Year: 2011
    ..pulmonary diseases including respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD), and other lung diseases. The 5'UTR of SP-A1 and SP-A2 generates a number of splice variants, and these 5'UTR variants ..
  68. Domestic endotoxin exposure and chronic obstructive pulmonary disease
    Nadia Hansel; Fiscal Year: 2009
    ..epidemiological studies which link domestic endotoxin exposure with adverse health outcomes in other chronic lung diseases, including asthma...
    Carlos Camargo; Fiscal Year: 2002
    ..The proposed study is cost-effective, as it makes use of an existing cohort, and it will provide information that could have direct clinical application to reduce risk of COPD. ..
  70. Redox Biology in COPD
    Yvonne Janssen Heininger; Fiscal Year: 2009
    ..Completion of this grant proposal may also offer new insights into the mechanisms whereby oxidants regulate the severity of inflammation. ..
  71. Estimating the Environmental Burden in Two Orphan Lung Diseases
    MARK DOUGLAS EISNER; Fiscal Year: 2010
    ..For selected orphan lung diseases, quantifying the environmentally-related PAF would provide important guidance for clinicians in diagnosis and ..
  72. Integration by Airway Parasympathic Ganglia Neurons
    Allen Myers; Fiscal Year: 2004
    ..We feel that an understanding of the mechanism of this integration is a prerequisite to obtaining knowledge on the mechanisms by which airway neurophysiology is regulated in health and disregulated in disease. ..